@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0280: (2015-12-29 )
MSIEIRNVSKNFNAFKALDDINLDIQSGELVALLGPSGCGKTTLLRIIAGLETPDAGNIVFHGEDVSQHDVRDRNVGFVFQHYALFRHMTVFDNVAFGLRMKPKGERPGESAIKAKVHELLNMVQLDWLADRYPEQLSGGQRQRIALARALAVEPKILLLDEPFGALDAKVRKELRRWLARLHEEINLTSVFVTHDQEEAMEVADRIVVMNKGVIEQIGSPGEVYENPASDFVYHFLGDSNRLQLGNDQHLLFRPHEVSLSRSAVAEHRAAEVRDIRPLGAITRVTLKVDGQDELIEAEVVKDHDSLAGLARGETLYFKPKAFQPVANL
Atome Classification :
(38 SA)
--.........10.-.-...--...20........30........40........50........60..-----....----.----.70---.-----.----.......80........90.......-.-100--.......110.-......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230......-----------.--240---------------....------------------.---------------------------------....250-----------------------.......260....----....-----270.......280......-.290-.----......300..-.....310.......320.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--M
S
I
E
I
R
NVSKNF-
N
-
A
F
K
--AL
D
D
I
N
L
D
IQS
G
E
L
V
A
L
LGPSGC
G
K
T
T
L
L
R
I
I
AGLETPDAG
N
I
V
F
HG-----EDV
S
----
Q
----HD----V-----R----DRN
V
G
F
V
F
Q
H
Y
A
L
F
R
H
M
T
V
F
DN
V
A
F
G
-
L
-RMK--PKGERP
G
E
S
A
I
-
K
A
K
V
H
E
L
L
N
M
V
Q
L
D
W
L
A
D
RY
P
E
Q
LSGG
Q
R
Q
R
I
A
L
A
R
ALAVE
P
K
I
L
L
LDEPF
G
A
L
D
A
K
V
R
K
E
L
R
R
W
L
A
R
L
H
E
EIN
L
T
S
V
F
V
TH
D
Q
E
E
A
M
E
V
A
D
R
I
VVMN
K
G
V
I
E
QIGSPGEVYENP
A
S
D
F
V
Y
H
FLG-----------D--S-----------------N
R
L
Q
------------------L---------------------------------GNDQ
H
L
L
-----------------------FRPHEVS
L
-
S
R
S
A
V
----
A
E
H
R
-----
A
A
E
VRDIRPLG
A
I
T
R
V
T
L
K
-VDGQ-D----EL
I
E
A
E
V
V
KD
H
-
D
S
L
A
GLARG
E
T
L
Y
FKPKAFQPVANL
104
HHSearch
85.30
43%
-109
- C1 -
1Z47
1
?
A:
[13-349]
--
M
T
I
E
F
V
G
V
E
K
I
Y
-
P
G
G
A
R
--
S
V
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V
S
F
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M
V
G
L
L
G
P
S
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G
K
T
T
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L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
-----
K
R
V
T
----
D
----
L
P
----
P
-----
Q
----
K
R
N
V
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L
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A
L
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Q
H
M
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Y
D
N
V
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F
G
-
L
-
R
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K
--
R
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----
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M
-
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L
L
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R
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V
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V
L
V
L
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N
V
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V
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K
P
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A
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F
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G
-----------
E
--
S
-----------------
N
V
W
T
------------------
R
A
V
Q
NG
R
I
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V
AG
A
A
L
P
V
DPAVSE-----------
G
S
E
V
A
V
V
-----------------------
V
R
P
K
D
V
E
L
-
Q
P
A
S
E
-----
R
E
A
-----
H
A
Q
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V
R
S
A
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K
G
S
Y
S
A
C
W
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-
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V
----
W
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--
H
V
P
--
S
-
A
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R
W
S
P
G
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
-
103
HHSearch
85.01
45%
-108
- C1 -
2IT1
-
?
A:
[3-347]
---
E
I
K
L
E
N
I
V
K
K
F
-
G
-
N
F
T
--
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
-----
K
D
V
T
----
E
----
L
P
----
P
-----
K
----
D
R
N
V
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
-
L
-
E
L
R
--
K
A
----
P
R
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I
-
D
K
K
V
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V
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K
M
L
H
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L
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R
Y
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W
Q
L
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G
G
Q
Q
Q
R
V
A
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A
R
A
L
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L
L
L
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L
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N
L
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A
L
L
R
L
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V
R
A
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L
K
R
L
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K
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T
T
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V
T
H
D
Q
A
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A
L
A
M
A
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R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
G
-----------
N
--
P
P
M
---------------
N
F
V
E
------------------
A
K
VEDGKLVITEK
S
K
L
P
IPKQY
V
E
I
V
K
E
T
G----
I
T
E
V
I
I
G
-----------------------
F
R
P
H
D
A
E
I
-
V
K
G
E
-----
G
E
G
I
-----
V
G
E
V
Y
S
F
E
P
L
G
R
E
Q
I
V
T
V
S
-
V
N
D
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-
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----
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--
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A
P
-----
E
G
E
H
F
S
F
G
E
K
V
T
I
K
V
K
E
E
L
L
V
L
F
D
108
HHSearch
84.89
38%
-108
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-353]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
-
E
V
V
--
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
-----
K
R
M
N
----
D
----
T
P
----
P
-----
A
----
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
-
K
L
A
--
G
A
----
K
K
E
V
I
-
N
Q
R
V
N
Q
V
A
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V
L
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
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A
I
G
R
T
L
V
A
E
P
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V
F
L
L
D
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P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
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S
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L
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K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
-----------
S
--
P
K
M
---------------
N
F
L
P
------------------
V
K
V
TATAID
Q
V
Q
V
E
L
PMPNR
Q
Q
V
W
L
PVESRDVQV
G
A
N
M
S
L
G
-----------------------
I
R
P
E
H
L
L
P
-
S
D
I
-
A
----
D
V
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L
-----
E
G
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Q
V
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G
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V
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Q
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L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
105
HHSearch
83.62
41%
-108
- C1 -
2YYZ
3
?
A:
[2-348]
--
P
S
I
R
V
V
N
L
K
K
Y
F
-
G
-
K
V
K
--
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
I
Y
F
D
D
-----
V
L
V
N
----
D
----
I
P
----
P
-----
K
----
Y
R
E
V
G
M
V
F
Q
N
Y
A
L
Y
P
H
M
T
V
F
E
N
I
A
F
P
-
L
-
R
A
R
--
R
I
----
S
K
D
E
V
-
E
K
R
V
V
E
I
A
R
K
L
L
I
D
N
L
L
D
R
K
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
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N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
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Q
E
L
G
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
Q
G
K
L
V
Q
Y
G
T
P
D
E
V
Y
D
S
P
K
N
M
F
V
A
S
F
I
G
-----------
N
--
P
P
T
---------------
N
F
L
R
------------------
D
F
S
V
S
V
E
NK
Q
T
I
L
K
R
DD
V
I
I
K
L
P
E
P
V
D
V
K-----
L
K
E
V
V
V
G
-----------------------
I
R
P
E
H
C
R
I
-
S
R
E
R
V
----
E
N
S
I
-----
P
G
V
V
Y
V
V
E
P
L
G
R
D
I
I
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N
V
K
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T
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K
G
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E
----
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I
K
--
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----
D
T
G
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A
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Q
P
G
E
N
V
F
L
V
P
D
L
R
K
I
H
L
F
N
122
Fugue
81.29
42%
-104
- C1 -
1Z47
1
?
A:
[11-355]
GS
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
-
G
A
R
--
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
-----
K
R
V
T
----
D
----
L
P
----
P
-----
Q
----
K
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
-
R
E
K
------
R
V
P
K
D
E
M
-
D
A
R
V
R
E
L
L
R
F
M
R
L
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Y
A
N
R
F
P
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E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
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P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
-----------
E
--
S
-----------------
N
V
W
T
------------------
R
A
V
Q
NG
R
I
E
V
AG
A
A
L
P
V
DPAVSE-----------
G
S
E
V
A
V
V
-----------------------
V
R
P
K
D
V
E
L
-
Q
P
A
S
-----
E
R
E
A
-----
H
A
Q
V
V
R
S
A
F
K
G
S
Y
S
A
C
W
I
R
-
T
K
D
G
-
E
-------
V
W
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V
H
V
P
S
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A
D
R
H
R
W
S
P
G
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
-
5
PsiBlast_PDB
78.66
39%
-106
- C1 -
2YYZ
3
?
A:
[3-342]
---
S
I
R
V
V
N
L
K
K
Y
F
-
G
-
K
V
K
--
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
I
Y
F
-------
D
D
V
L
----
V
----
N
D
----
I
PP---
K
----
Y
R
E
V
G
M
V
F
Q
N
Y
A
L
Y
P
H
M
T
V
F
E
N
I
A
F
P
-
L
-
R
A
R
------
R
I
S
K
D
E
V
-
E
K
R
V
V
E
I
A
R
K
L
L
I
D
N
L
L
D
R
K
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
E
L
G
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
Q
G
K
L
V
Q
Y
G
T
P
D
E
V
Y
D
S
P
K
N
M
F
V
A
S
F
I
G
-----------
N
P
P
T
-----------------
N
F
L
R
D
F
S
V
S
-------------
V
---------------------------------
E
N
K
Q
T
I
L
K
R
DD
V
I
I
K
L
P
E
P
V
D
V
KLK
E
V
V
V
G
I
R
P
E
H
C
R
I
-
S
R
E
R
V
----
E
N
S
I
-----
P
G
V
V
Y
V
V
E
P
L
G
R
D
I
I
V
N
V
K
-
T
E
-----------
K
G
E
I
I
K
V
F
G
D
T
G
K
A
P
Q
P
G
E
N
V
F
L
V
P
D
L
R
K
I
H
L
F
N
22
PsiBlast_CBE
78.12
42%
-124
- C1 -
2IT1
1
?
B:
[2-317]
--
V
E
I
K
L
E
N
I
V
K
K
F
-
G
-
N
F
T
--
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
-----
K
D
V
T
----
E
----
L
P
----
P
-----
K
----
D
R
N
V
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
-
L
-
E
L
R
-----
K
A
P
R
E
E
-
I
-
D
K
K
V
R
E
V
A
K
M
L
H
I
D
K
L
L
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
G
NP
P
M
N
F
V
E
A
K
V
E
--
D
-----------------
G
K
L
V
------------------
I
---------------------------------
T
E
K
S
K
L
P
IPKQY
V
E
I
V
K
E
T
GIT
E
V
I
I
G
---
F
R
P
H
D
A
E
I
-
V
K
G
E
-----
G
E
G
I
-----
V
G
E
V
Y
S
F
E
P
L
G
R
E
Q
I
V
T
V
S
-
V
N
D
S
-
I
----
V
K
V
F
A
P
E
G
E
H
F
-
S
F
G
E
K
V
T
I
K
V
K
E
E
L
L
V
L
F
D
K
K
T
E
K
A
2
PsiBlast_PDB
78.02
42%
-117
- C1 -
2IT1
-
?
A:
[2-317]
--
V
E
I
K
L
E
N
I
V
K
K
F
-
G
-
N
F
T
--
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
-----
K
D
V
T
----
E
----
L
P
----
P
-----
K
----
D
R
N
V
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
-
L
-
E
L
R
-----
K
A
P
R
E
E
-
I
-
D
K
K
V
R
E
V
A
K
M
L
H
I
D
K
L
L
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
G
NP
P
M
N
F
V
E
A
K
V
E
--
D
-----------------
G
K
L
V
------------------
I
---------------------------------
T
E
K
S
K
L
P
IPKQY
V
E
I
V
K
E
T
GIT
E
V
I
I
G
---
F
R
P
H
D
A
E
I
-
V
K
G
E
-----
G
E
G
I
-----
V
G
E
V
Y
S
F
E
P
L
G
R
E
Q
I
V
T
V
S
-
V
N
D
S
-
I
----
V
K
V
F
A
P
E
G
E
H
F
-
S
F
G
E
K
V
T
I
K
V
K
E
E
L
L
V
L
F
D
K
K
T
E
K
A
101
HHSearch
76.65
40%
-116
- C1 -
1V43
-
?
A:
[12-362]
---
E
V
K
L
E
N
L
T
K
R
F
-
G
-
N
F
T
--
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
-----
R
D
V
T
----
Y
----
L
P
----
P
-----
K
----
D
R
N
I
S
M
V
F
Q
------
H
M
T
V
Y
E
N
I
A
F
P
-
L
---
K
--
K
F
----
P
K
D
E
I
-
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
L
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
-----------
A
--
P
EM---------------
N
I
L
E
------------------
V
S
V
G
DG
Y
L
E
G
RG
F
R
I
E
L
P
QMDLLKDYV-------
G
K
T
V
L
F
G
-----------------------
I
R
P
E
H
M
T
V
-
E
G
V
--HMK
R
T
A
R
L
-----
I
G
K
V
D
F
V
E
A
L
G
T
D
T
I
L
H
V
K
-
F
G
D
E
-
L
----
V
K
V
--
K
L
P
-----
G
H
I
P
I
E
P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
F
D
50
PsiBlast_CBE
74.77
36%
-102
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[4-347]
---
A
L
H
I
G
H
L
S
K
S
F
-
Q
-
N
T
P
--
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
-----
K
T
I
F
----
S
----
K
N
TNLP
V
-----
R
----
E
R
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
-
L
--------
G
N
G
K
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
-----------
E
--
G
IVFPAALNADGTADCRL
G
R
L
P
------------------
V
QSGAPA---------------------------
G
T
R
G
T
L
L
-----------------------
I
R
P
E
Q
Y
S
L
H
P
H
S
A
P
----
A
A
S
I
-----
H
A
V
V
L
K
T
T
P
K
A
R
H
T
E
I
S
L
R
-
A
-
G
Q
-
T
VLTL
N
L
P
S
A
P
T
L
S
D
G
-
I
S
A
V
L
H
L
D
G
P
A
L
F
F
P
G
N
T
-------
51
PsiBlast_CBE
74.58
36%
-102
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[4-347]
---
A
L
H
I
G
H
L
S
K
S
F
-
Q
-
N
T
P
--
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
-----
K
T
I
F
----
S
----
K
N
T
N
L
P
V
-----
R
----
E
R
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
-
L
--------
G
N
G
K
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
-----------
E
--
G
I
V
F
P
A
A
L
N
ADG
T
A
D
C
RL
G
R
L
P
------------------
V
Q
S
GAPA---------------------------
G
T
R
G
T
L
L
-----------------------
I
R
P
E
Q
Y
S
L
H
P
H
S
A
P
----
A
A
S
I
-----
H
A
V
V
L
K
T
T
P
K
A
R
H
T
E
I
S
L
R
-
A
-
G
Q
-
T
V
L
T
L
N
L
-----
L
S
D
G
-
I
S
A
V
L
H
L
D
G
P
A
L
F
F
P
G
---------
107
HHSearch
73.61
37%
-100
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[4-343]
---
A
L
H
I
G
H
L
S
K
S
F
-
Q
-
N
T
P
--
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
-----
K
T
I
F
SKN
T
N
----
L
P
----
V
-----
R
----
E
R
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
-
L
-
G
N
G
--
K
G
----
R
T
A
Q
E
-
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
-----------
E
--
G
-----------------
I
V
F
P
------------------
A
A
L
N
ADG
T
A
D
C
RLGR
L
P
V
Q
S
GAPA----------
G
T
R
G
T
L
L
-----------------------
I
R
P
E
Q
Y
S
L
-
H
P
H
S
A
P---
A
A
S
I
-----
H
A
V
V
L
K
T
T
P
K
A
R
H
T
E
I
S
L
R
-
A
G
Q
T
-
V
----
L
T
L
--
N
L
----------
L
S
D
G
I
S
A
V
L
H
L
D
G
P
A
L
F
F
P
G
1
PsiBlast_PDB
73.55
52%
-130
- C1 -
1Z47
1
?
A:
[13-250]
--
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
-
G
A
R
--
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
-----
K
R
V
T
----
D
----
L
P
----
P
-----
Q
----
K
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
-
R
E
K
RV
P
K
D
E
------
M
-
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
-----------
E
--
S
-----------------
N
V
W
T
------------------
R
---------------------------------
A
V
Q
N
G
R
I
-----------------------
E
V
A
G
A
A
L
P
-
V
D
P
A
V
----
S
E
G
S
-----
E
V
A
V
V
V
R
P
K
D
V
E
L
Q
P
A
S
E
R
-
E
A
H
A
-
Q
----
V
V
R
S
A
F
K
G
S
Y
S
-
A
C
W
I
R
T
K
D
G
E
V
W
E
V
H
V
P
S
A
D
R
H
R
W
S
21
PsiBlast_CBE
71.82
52%
-129
- C1 -
1Z47
1
?
B:
[14-250]
---
T
I
E
F
V
G
V
E
K
I
Y
P
G
-
G
A
R
--
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
-----
K
R
V
T
----
D
----
L
P
----
P
-----
Q
----
K
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
-
R
E
K
RV
P
K
D
E
------
M
-
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
-----------
E
--
S
-----------------
N
V
W
T
------------------
R
---------------------------------
A
V
Q
N
G
R
I
-----------------------
E
V
A
G
A
A
L
P
-
V
D
P
A
V
----
S
E
G
S
-----
E
V
A
V
V
V
R
P
K
D
V
E
L
Q
P
A
S
E
R
-
E
A
H
A
-
Q
----
V
V
R
S
A
F
K
G
S
Y
S
-
A
C
W
I
R
T
K
D
G
E
V
W
E
V
H
V
P
S
A
D
R
H
R
W
S
102
HHSearch
71.26
38%
-89
- C1 -
3D31
2
?
A:
[1-345]
---
M
I
E
I
E
S
L
S
R
K
W
-
K
-
N
-
F
--
S
L
D
N
L
S
L
K
V
E
S
G
E
Y
F
V
I
L
G
P
T
G
A
G
K
T
L
F
L
E
L
I
A
G
F
H
V
P
D
S
G
R
I
L
L
D
G
-----
K
D
V
T
----
D
----
L
S
----
P
-----
E
----
K
H
D
I
A
F
V
Y
Q
N
Y
S
L
F
P
H
M
N
V
K
K
N
L
E
F
G
-
M
-
R
M
K
--
K
I
-------
K
D
-
P
K
R
V
L
D
T
A
R
D
L
K
I
E
H
L
L
D
R
N
P
L
T
L
S
G
G
E
Q
Q
R
V
A
L
A
R
A
L
V
T
N
P
K
I
L
L
L
D
E
P
L
S
A
L
D
P
R
T
Q
E
N
A
R
E
M
L
S
V
L
H
K
K
N
K
L
T
V
L
H
I
T
H
D
Q
T
E
A
R
I
M
A
D
R
I
A
V
V
M
D
G
K
L
I
Q
V
G
K
P
E
E
I
F
E
K
P
V
E
G
R
V
A
S
F
V
G
-----------
F
--
E
-----------------
N
V
L
K
------------------
G
RVISAEQG
L
L
R
I
R
V
GE
V
V
I
D
A
A
G
DMEV------
G
D
Q
V
Y
A
F
-----------------------
L
R
P
E
N
I
A
L
-
S
K
S
S
T
QSSI
R
N
S
L
-----
Q
G
R
V
T
E
A
W
V
L
G
A
L
V
R
V
K
V
D
-
C
G
V
--
P
----
L
N
V
--
L
I
T
R
R
S
-
A
E
E
M
E
L
S
P
G
V
Q
I
Y
A
R
F
K
A
S
S
V
H
V
L
R
44
PsiBlast_CBE
70.58
34%
-112
- C1 -
1OXV
7
?
A:
[4-324]
----
I
I
V
K
N
V
S
K
V
F
-
K
-
K
G
K
VV
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
-----
R
L
V
A
----
S
----
N
G
----
K
LIVPP
E
----
D
R
K
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
-
L
T
N
M
K
--
M
S
K
E
E
-----
I
-
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
-----------
E
--
I
-----------------
N
E
L
E
G
K
V
T
NEGVVIGSLRFPVS
V
---------------------------------
S
S
D
R
A
I
I
G
----------------------
I
R
P
E
D
V
K
L
-
S
K
D
V
I
----
K
D
D
S
WILV
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
-
E
----
E
I
F
T
Y
S
D
H
P
I
H
-
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
N
-----
46
PsiBlast_CBE
70.54
34%
-116
- C1 -
1OXU
7
?
B:
[4-324]
----
I
I
V
K
N
V
S
K
V
F
-
K
-
K
G
K
VV
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
-----
R
L
V
A
----
S
----
N
G
----
K
LIVPP
E
----
D
R
K
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
-
L
T
N
M
K
--
M
S
K
E
E
-----
I
-
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
-----------
E
--
I
-----------------
N
E
L
E
GKVTNEGVVIGSLRFPVS
V
---------------------------------
S
S
D
R
A
I
I
G----------------------
I
R
P
E
D
V
K
L
-
S
K
D
V
I
----
K
D
D
S
WILVG
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
-
E
----
E
I
F
T
Y
S
D
H
P
I
H
-
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
N
-----
43
PsiBlast_CBE
70.40
34%
-115
- C1 -
1OXV
5
?
B:
[4-324]
----
I
I
V
K
N
V
S
K
V
F
-
K
-
K
G
K
VV
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
-----
R
L
V
A
----
S
----
N
G
----
K
LIVPP
E
----
D
R
K
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
-
L
T
N
M
K
--
M
S
K
E
E
-----
I
-
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
-----------
E
--
I
-----------------
N
E
L
E
GKVTNEGVVIGSLRFPVS
V
---------------------------------
S
S
D
R
A
I
I
G----------------------
I
R
P
E
D
V
K
L
-
S
K
D
V
I
----
K
D
D
S
WILVG
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
-
E
----
E
I
F
T
Y
S
D
H
P
I
H
-
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
N
-----
28
PsiBlast_CBE
70.29
44%
-124
- C1 -
3PUX
5
MALK_ECOLI
B:
[3-236]
---
S
V
Q
L
Q
N
V
T
K
A
W
-
G
-
E
V
V
--
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
-----
K
R
M
N
----
D
----
T
P
----
P
-----
A
----
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
-
K
L
A
----
G
A
K
--
K
E
V
I
-
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
-----------
S
--
P
-----------------
K
M
N
F
------------------
L
---------------------------------
P
V
T
A
T
A
I
-----------------------
D
Q
V
Q
V
E
L
P
-
M
P
N
R
Q
----
Q
V
W
L
-----
P
V
E
N
M
S
L
G
I
R
P
E
H
L
L
P
S
D
I
-
A
D
V
I
-
L
----
E
G
E
V
Q
V
V
E
Q
L
G
-
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
30
PsiBlast_CBE
70.15
44%
-123
- C1 -
3PUV
5
MALK_ECOLI
B:
[3-236]
---
S
V
Q
L
Q
N
V
T
K
A
W
-
G
-
E
V
V
--
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
-----
K
R
M
N
----
D
----
T
P
----
P
-----
A
----
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
-
K
L
A
----
G
A
K
--
K
E
V
I
-
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
-----------
S
--
P
-----------------
K
M
N
F
------------------
L
---------------------------------
P
V
T
A
T
A
I
-----------------------
D
Q
V
Q
V
E
L
P
-
M
P
N
R
Q
----
Q
V
W
L
-----
P
V
E
N
M
S
L
G
I
R
P
E
H
L
L
P
S
D
I
-
A
D
V
I
-
L
----
E
G
E
V
Q
V
V
E
Q
L
G
-
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
56
PsiBlast_CBE
63.33
41%
-115
- C1 -
3C4J
4
?
B:
[25-259]
----
I
D
V
H
Q
L
K
K
S
F
-
G
-
S
L
E
--
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKA
K
D
T
N
----
L
----
N
K
----
V
-----
R
----
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
--
V
R
-
K
W
P
R
E
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
-----------
K
--
V
-----------------
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
60.98
41%
-110
- C1 -
3C41
3
?
K:
[4-238]
----
I
D
V
H
Q
L
K
K
S
F
-
G
-
S
L
E
--
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKA
K
D
T
N
----
L
----
N
K
----
V
-----
R
----
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
--
V
R
-
K
W
P
R
E
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
-----------
K
--
V
-----------------
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
60.37
41%
-109
- C1 -
2OLK
1
?
D:
[25-259]
----
I
D
V
H
Q
L
K
K
S
F
-
G
-
S
L
E
--
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKA
K
D
T
N
----
L
----
N
K
----
V
-----
R
----
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
--
V
R
-
K
W
P
R
E
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
-----------
K
--
V
-----------------
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
60.31
41%
-108
- C1 -
2OLK
2
?
B:
[25-259]
----
I
D
V
H
Q
L
K
K
S
F
-
G
-
S
L
E
--
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKA
K
D
T
N
----
L
----
N
K
----
V
-----
R
----
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
--
V
R
-
K
W
P
R
E
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
-----------
K
--
V
-----------------
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
59.29
42%
-121
- C1 -
4U00
3
?
A:
[5-238]
----
I
R
I
R
N
L
H
K
W
F
-
G
-
P
L
H
--
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
LSVK-
D
D
R
A
----
L
----
R
E
----
I
-----
R
-----
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
-
R
V
R
-----
R
W
P
R
E
K
A
E
-
K
-
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
-----------
R
--
V
-----------------
L
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
59.07
41%
-110
- C1 -
2OLK
1
?
C:
[25-259]
----
I
D
V
H
Q
L
K
K
S
F
-
G
-
S
L
E
--
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKA
K
D
T
N
----
L
----
N
K
----
V
-----
R
----
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
--
V
R
-
K
W
P
R
E
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
-----------
K
--
V
-----------------
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
58.81
41%
-110
- C1 -
3C41
3
?
J:
[4-238]
----
I
D
V
H
Q
L
K
K
S
F
-
G
-
S
L
E
--
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKA
K
D
T
N
----
L
----
N
K
----
V
-----
R
----
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
--
V
R
-
K
W
P
R
E
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
-----------
K
--
V
-----------------
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
58.73
41%
-110
- C1 -
3C4J
3
?
A:
[25-259]
----
I
D
V
H
Q
L
K
K
S
F
-
G
-
S
L
E
--
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKA
K
D
T
N
----
L
----
N
K
----
V
-----
R
----
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
--
V
R
-
K
W
P
R
E
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
-----------
K
--
V
-----------------
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
58.57
41%
-111
- C1 -
2OLJ
4
?
A:
[25-259]
----
I
D
V
H
Q
L
K
K
S
F
-
G
-
S
L
E
--
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKA
K
D
T
N
----
L
----
N
K
----
V
-----
R
----
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
--
V
R
-
K
W
P
R
E
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
-----------
K
--
V
-----------------
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
58.33
41%
-109
- C1 -
2OLK
1
?
A:
[25-259]
----
I
D
V
H
Q
L
K
K
S
F
-
G
-
S
L
E
--
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKA
K
D
T
N
----
L
----
N
K
----
V
-----
R
----
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
--
V
R
-
K
W
P
R
E
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
-----------
K
--
V
-----------------
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
58.02
37%
-114
- C1 -
4YMU
2
?
J:
[2-236]
----
I
F
V
N
D
V
Y
K
N
F
-
G
-
S
L
E
--
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-----
V
K
I
N
----
N
----
G
K
----
V
-----
N
INKV
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
-
K
V
K
--
K
M
N
K
K
E
A
E
E
L
-----
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
-----------
K
--
I
-----------------
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
57.97
41%
-103
- C1 -
2Q0H
4
?
A:
[25-259]
----
I
D
V
H
Q
L
K
K
S
F
-
G
-
S
L
E
--
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKA
K
D
T
N
----
L
----
N
K
----
V
-----
R
----
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
--
V
R
-
K
W
P
R
E
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
-----------
K
--
V
-----------------
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
57.70
37%
-117
- C1 -
4YMU
2
?
A:
[2-236]
----
I
F
V
N
D
V
Y
K
N
F
-
G
-
S
L
E
--
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-----
V
K
I
N
----
N
----
G
K
----
V
-----
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
-
K
V
K
--
K
M
N
K
K
E
A
E
E
L
-----
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
-----------
K
--
I
-----------------
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
57.55
41%
-107
- C1 -
2Q0H
4
?
B:
[25-259]
----
I
D
V
H
Q
L
K
K
S
F
-
G
-
S
L
E
--
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKA
K
D
T
N
----
L
----
N
K
----
V
-----
R
----
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
--
V
R
-
K
W
P
R
E
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
-----------
K
--
V
-----------------
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
HHSearch
56.99
39%
-113
* C1 *
2OLJ
4
?
A:
[24-260]
---
M
I
D
V
H
Q
L
K
K
S
F
-
G
-
S
L
E
--
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-----
I
N
L
K
----
A
KDTN
L
N
----
K
-----
V
----
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-
P
-
M
K
V
--
R
K
W
---
P
R
E
K
A
-
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
-----------
K
--
V
-----------------
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
55.88
37%
-115
- C1 -
4YMV
1
?
A:
[2-236]
----
I
F
V
N
D
V
Y
K
N
F
-
G
-
S
L
E
--
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-----
V
K
I
N
----
N
----
G
K
----
V
-----
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
-
K
V
K
--
K
M
N
K
K
E
A
E
E
L
-----
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
-----------
K
--
I
-----------------
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
55.47
41%
-102
- C1 -
2OLJ
3
?
B:
[25-259]
----
I
D
V
H
Q
L
K
K
S
F
-
G
-
S
L
E
--
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKA
K
D
T
N
----
L
----
N
K
----
V
-----
R
----
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
--
V
R
-
K
W
P
R
E
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
-----------
K
--
V
-----------------
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
54.53
37%
-115
- C1 -
4YMV
1
?
J:
[2-236]
----
I
F
V
N
D
V
Y
K
N
F
-
G
-
S
L
E
--
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-----
V
K
I
N
----
N
----
G
K
----
V
-----
N
INKV
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
-
K
V
K
--
K
M
N
K
K
E
A
E
E
L
-----
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
-----------
K
--
I
-----------------
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------