@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0302: (2015-12-30 )
MAIASGAYKKALEGNQQPKEVLVKIDRVTKQFDETLAVDTVSLTINKGEIFALLGGSGSGKSTLLRMLAGFERPTEGRIFLDGQDITDLPPYERPINMMFQSYALFPHMSVAQNIAFGLKQDGLPKAEIDERVAEMLKLVHMTQYAKRKPHQLSGGQRQRVALARSLAKRPKLLLLDEPMGALDKKLRSQMQLELVEIIERVGVTCVMVTHDQEEAMTMAQRIAIMHLGCIEQIGSPMDIYETPASRLVCEFIGNVNLFDGVLVEDVQDHAVIACPQLENPIYIGHGISTRAEDKRITYALRPEKVMISAQKPDNLEHAGHNWAQGTVYDIAYLGGHSVYYIKLASGMIVQAFMANAERHVARPTWDQSVYISWYDDSGVVLQS
Atome Classification :
(39 SA)
.........10........20........30..--.--.....40........50........60........70........80.....---------------.----.------.90........100.......110......-.120-.......130.......140.......-150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250...--.--...260......-..-----.270.....-..280......---.290........300.......310-........320.......330.......340......-.350.......360..-.....370.......380..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAIAS
G
A
Y
K
K
A
LEGNQ
Q
P
K
E
V
L
V
K
I
D
R
V
T
K
Q
FD--E--T
L
A
V
D
T
V
S
L
T
INK
G
E
I
F
A
L
LGGSGS
G
K
S
T
L
L
R
M
L
AGFERPTE
G
R
I
F
LDGQDI---------------T----D------LPPYE
R
P
I
N
M
M
F
Q
S
Y
ALFP
H
M
S
V
A
Q
N
I
A
F
G
-
L
KQD-GL
P
K
A
E
I
D
E
R
V
A
E
M
L
K
L
V
H
M
T
Q
Y
A
KRK-PHQLSGG
Q
R
Q
R
V
A
L
A
R
S
L
AKRP
K
L
L
L
LDE
P
M
G
A
L
D
K
K
L
R
S
Q
M
Q
L
E
L
V
E
I
I
E
RVG
V
T
C
V
M
V
TH
D
Q
E
E
A
M
T
M
A
Q
R
I
A
I
M
H
L
G
C
I
E
QIGSPM
D
I
YET
P
A
S
R
L
V
C
E
F
IGN--V--NLF
D
--
G
V
L
V
E
D-VQ-----D
H
A
V
I
ACPQ-LEN
P
I
Y
IGHGI---STR-AED
K
R
I
T
Y
A
LRP
E
K
V
M
I
SAQ--KPDNLEHAGHNWAQG
T
V
Y
D
I
A
Y
LGG
H
S
V
Y
Y
I
KLAS
G
M
-
I
V
Q
A
F
M
AN
A
E
R
HVARP-TWD
Q
S
V
Y
I
S
W
YDDS
G
V
V
LQS
119
HHSearch
90.46
35%
-121
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-356]
--------------------
A
S
V
Q
L
Q
N
V
T
K
A
W
G
--
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
---------------
N
----
D
------
T
P
P
A
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R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
-
G
A
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K
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Q
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V
L
Q
L
A
H
L
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D
R
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
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P
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V
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L
L
D
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P
L
S
N
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A
A
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R
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G
K
P
L
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L
Y
H
Y
P
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R
F
V
A
G
F
I
G
S
--
P
K
M
N
F
L
P
--
V
K
V
T
A
T
-
A
I
-----
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
S
---
R
D
V
-
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
S
D
I
--
A
--------
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
-
Q
N
---
D
V
V
L
V
-
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
115
HHSearch
90.02
38%
-129
- C1 -
2YYZ
3
?
A:
[2-352]
--------------------
P
S
I
R
V
V
N
L
K
K
Y
F
G
--
K
--
V
K
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
I
Y
F
D
D
V
L
V
---------------
N
----
D
------
I
P
P
K
Y
R
E
V
G
M
V
F
Q
N
Y
A
L
Y
P
H
M
T
V
F
E
N
I
A
F
P
-
L
R
A
R
-
R
I
S
K
D
E
V
E
K
R
V
V
E
I
A
R
K
L
L
I
D
N
L
L
D
R
K
-
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
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I
K
H
L
Q
Q
E
L
G
I
T
S
V
Y
V
T
H
D
Q
A
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A
M
T
M
A
S
R
I
A
V
F
N
Q
G
K
L
V
Q
Y
G
T
P
D
E
V
Y
D
S
P
K
N
M
F
V
A
S
F
I
G
N
--
P
P
T
N
F
L
R
--
D
F
S
V
S
V
-
E
N
-----
K
Q
T
I
L
K
R
---
D
D
V
I
I
K
L
P
E
P
-----
V
D
-
V
K
L
K
E
V
V
V
G
I
R
P
E
H
C
R
I
S
R
E
--
R
-------
V
E
N
S
I
P
G
V
V
Y
V
V
E
P
L
G
R
D
I
I
V
N
V
K
T
E
K
G
E
-
I
I
K
V
F
G
D
----
T
G
K
A
P
-
Q
P
G
E
N
V
F
L
V
P
D
L
R
K
I
H
L
F
N
P
117
HHSearch
89.76
36%
-112
- C1 -
1Z47
1
?
A:
[11-354]
------------------
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
G-
G
--
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
---------------
T
----
D
------
L
P
P
Q
K
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
R
E
K
-
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
Y
A
N
R
F
-
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
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L
R
T
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R
Q
V
H
D
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M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
--
S
--
N
V
W
T
--
R
A
V
Q
N
G
-
R
I
-----
E
V
--------
A
G
A
A
L
P
V
D
P
------
A
V
-
S
E
G
S
E
V
A
V
V
V
R
P
K
D
V
E
L
Q
P
A
--
S
--------
E
R
E
A
H
A
Q
V
V
R
S
A
F
K
G
S
Y
S
A
C
W
I
R
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K
D
G
E
-
V
W
E
V
H
V
P
S
--
A
D
R
H
R
W
-
S
P
G
A
W
V
H
M
N
V
--
T
R
W
F
I
F
P
R
116
HHSearch
89.62
37%
-121
- C1 -
2IT1
-
?
A:
[2-350]
--------------------
V
E
I
K
L
E
N
I
V
K
K
F
G
--
N
--
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
K
D
V
---------------
T
----
E
------
L
P
P
K
D
R
N
V
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
-
L
E
L
R
-
K
A
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
D
K
L
L
N
R
Y
-
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
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K
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P
E
V
L
L
L
D
E
P
L
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N
L
D
A
L
L
R
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V
R
A
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L
K
R
L
Q
K
E
L
G
I
T
T
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Y
V
T
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D
Q
A
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A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
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G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
G
N
--
P
P
M
N
F
V
E
--
A
K
V
E
D
G
-
K
L
-----
V
I
----
T
---
E
K
S
K
L
P
I
P
K
Q
Y
V
E
I
V
K
E
-
T
G
I
T
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G
F
R
P
H
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A
E
I
V
K
G
--
E
--------
G
E
G
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G
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Y
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P
L
G
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T
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V
F
A
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-
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F
G
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K
V
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K
V
K
E
E
L
L
V
L
F
D
K
114
HHSearch
89.61
39%
-115
- C1 -
1V43
-
?
A:
[7-366]
----------------
V
I
K
M
V
E
V
K
L
E
N
L
T
K
R
F
G
--
N
--
F
T
A
V
N
K
L
N
L
T
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K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
D
V
---------------
T
----
Y
------
L
P
P
K
D
R
N
I
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M
V
F
Q
------
H
M
T
V
Y
E
N
I
A
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P
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L
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K
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K
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A
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G
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L
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L
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A
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A
T
F
I
G
A
--
P
EM
N
I
L
E
--
V
S
V
G
D
G
-
Y
L
-----
E
G
--------
R
G
F
R
I
E
L
P
Q
--MDL
L
K
D
-
Y
V
G
K
T
V
L
F
G
I
R
P
E
H
M
T
V
E
G
V
-------
H
M
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K
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D
F
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A
L
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D
T
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D
-
E
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L
V
K
V
K
L
P
G
----
H
I
P
I
-
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G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
F
D
K
103
Fugue
88.34
36%
-113
- C1 -
1Z47
1
?
A:
[11-355]
------------------
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
G-
G
--
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
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G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
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G
D
V
W
I
G
G
K
R
V
---------------
T
----
D
------
L
P
P
Q
K
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N
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N
Y
A
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-
L
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K
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R
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A
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P
H
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G
Q
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R
V
A
L
A
R
A
L
A
P
R
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Q
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L
L
F
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E
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F
A
A
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R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
--
S
--
N
V
W
T
--
R
A
V
Q
N
G
---------
R
I
E
V
A
G
A
A
-
L
P
V
D
----------
P
A
V
-
S
E
G
S
E
V
A
V
V
V
R
P
K
D
V
E
L
Q
P
A
--
S
E
R
E
A
--------
H
A
Q
V
V
R
S
A
F
K
G
S
Y
S
A
C
W
I
R
T
K
D
G
E
-
V
W
E
V
H
V
P
S
A
D
R
----
H
-
R
W
S
P
G
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
21
PsiBlast_CBE
86.08
38%
-116
- C1 -
1Z47
1
?
B:
[30-351]
----------------------------------------
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
---------------
T
----
D
------
L
P
P
Q
K
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
R
E
K
-
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
Y
A
N
R
F
-
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
--
S
--
N
V
W
T
--
R
A
V
Q
N
G
-
R
I
-----
E
V
A
G
A
A
L
P
--------
V
D
P
A
V
---
S
----
E
G
S
E
V
A
V
V
V
R
P
K
D
V
----------
E
L
Q
P
A
S
E
R
E
A
H
A
Q
V
V
R
S
A
F
K
G
S
Y
S
A
C
W
I
R
T
K
D
G
E
-
V
W
E
V
H
V
P
S
A
D
R
H
R
W
S
P
G
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
-----
104
Fugue
85.57
32%
-113
- C1 -
1OXS
23
?
C:
[1-352]
M
V
-------------------
R
I
I
V
K
N
V
S
K
V
F
K
KG
K
--
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
---------------
A
----
S
NGKLI-
V
P
P
E
D
R
K
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
-
L
T
N
M
-
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
V
L
N
H
F
-
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
--
I
--
N
E
L
E
--
G
K
V
T
N
E
--------------------
G
V
V
I
G
S
L
R
F
---
P
V
S
-
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
K
D
--
V
I
K
D
--
D
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
-
E
E
I
F
T
Y
S
D
H
P
I
H
S
------
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
7
PsiBlast_PDB
84.96
39%
-122
- C1 -
4TQV
-
?
C:
[5-341]
----------------------
V
S
I
Q
N
V
V
K
R
Y
D
--
K
--
T
T
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
I
D
G
R
V
I
---------------
N
----
D
------
L
A
P
K
D
R
D
V
A
M
V
F
Q
N
Y
A
L
Y
P
H
L
N
V
R
D
N
I
S
F
G
-
L
R
L
K
-
R
T
K
K
S
V
I
D
A
A
V
K
T
A
A
D
I
L
G
L
Q
P
L
L
E
R
K
-
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
G
T
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
S
PP
M
--
N
L
M
P
--
A
R
I
A
V
D
-
S
T
-----
Q
H
V
E
L
N
G
----
G
N
R
I
S
L
L
P
R
A
---
G
T
H
L
A
P
G
Q
E
V
V
F
G
I
R
P
E
D
V
T
L
-------
D
G
V
E
G
S
E
R
A
Q
I
K
A
T
V
D
I
V
E
P
L
G
S
E
S
I
L
H
A
T
V
G
D
H
S
-
L
V
V
K
V
G
G
L
N
E
V
H
P
G
D
P
-
V
T
L
H
V
D
L
T
R
V
H
L
F
D
A
Q
S
Q
A
S
121
HHSearch
84.82
32%
-111
- C1 -
1OXX
25
?
K:
[1-352]
-------------------
M
V
R
I
I
V
K
N
V
S
K
V
F
K
--
K
GK
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
---------------
A
----
S
NGKLI-
V
P
P
E
D
R
K
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
-
L
T
N
M
-
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
V
L
N
H
F
-
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
--
I
--
N
E
L
E
--
G
K
V
T
N
E
-
G
V
-----
V
I
--------
G
S
--
L
R
F
P
-------
V
S
-
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
K
D
--
V
I
K
D
--
D
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
--
E
E
I
F
----
T
Y
S
D
H
P
I
-
H
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
6
PsiBlast_PDB
84.68
39%
-119
- C1 -
4TQU
-
?
S:
[5-341]
----------------------
V
S
I
Q
N
V
V
K
R
Y
D
--
K
--
T
T
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
I
D
G
R
V
I
---------------
N
----
D
------
L
A
P
K
D
R
D
V
A
M
V
F
Q
N
Y
A
L
Y
P
H
L
N
V
R
D
N
I
S
F
G
-
L
R
L
K
-
R
T
K
K
S
V
I
D
A
A
V
K
T
A
A
D
I
L
G
L
Q
P
L
L
E
R
K
-
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
G
T
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
S
PP
M
--
N
L
M
P
--
A
R
I
A
V
D
-
S
T
-----
Q
H
V
E
L
N
G
----
G
N
R
I
S
L
L
P
R
A
---
G
T
H
L
A
P
G
Q
E
V
V
F
G
I
R
P
E
D
V
T
L
-------
D
G
V
E
G
S
E
R
A
Q
I
K
A
T
V
D
I
V
E
P
L
G
S
E
S
I
L
H
A
T
V
G
D
H
S
-
L
V
V
K
V
G
G
L
N
E
V
H
P
G
D
P
-
V
T
L
H
V
D
L
T
R
V
H
L
F
D
A
Q
S
Q
A
S
1
PsiBlast_PDB
83.97
38%
-112
- C1 -
1Z47
1
?
A:
[30-351]
----------------------------------------
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
---------------
T
----
D
------
L
P
P
Q
K
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
R
E
K
-
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
Y
A
N
R
F
-
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
--
S
--
N
V
W
T
--
R
A
V
Q
N
G
-
R
I
-----
E
V
A
G
A
A
L
P
--------
V
D
P
A
V
---
S
----
E
G
S
E
V
A
V
V
V
R
P
K
D
V
----------
E
L
Q
P
A
S
E
R
E
A
H
A
Q
V
V
R
S
A
F
K
G
S
Y
S
A
C
W
I
R
T
K
D
G
E
-
V
W
E
V
H
V
P
S
A
D
R
H
R
W
S
P
G
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
-----
4
PsiBlast_PDB
82.37
40%
-124
- C1 -
2YYZ
3
?
A:
[4-325]
----------------------
I
R
V
V
N
L
K
K
Y
F
G
--
K
--
V
K
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
I
Y
F
D
D
V
L
V
---------------
N
----
D
------
I
P
P
K
Y
R
E
V
G
M
V
F
Q
N
Y
A
L
Y
P
H
M
T
V
F
E
N
I
A
F
P
-
L
R
A
R
-
R
I
S
K
D
E
V
E
K
R
V
V
E
I
A
R
K
L
L
I
D
N
L
L
D
R
K
-
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
E
L
G
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
Q
G
K
L
V
Q
Y
G
T
P
D
E
V
Y
D
S
P
K
N
M
F
V
A
S
F
I
G
N
P
P
T
--
N
F
L
R
D
F
S
V
S
V
E
N
-
K
Q
T
I
L
K
R
D
D
V
I
I
K
L
P
E
----
P
V
D
V
------------
K
L
K
E
V
V
V
G
I
R
P
E
H
C
R
I
S
R
E
--
R
V
E
-------
N
S
I
P
G
V
V
Y
V
V
E
P
L
G
R
D
I
I
V
N
V
K
T
E
K
G
E
-
I
I
K
V
F
G
D
T
G
K
A
P
Q
P
G
E
-
N
V
F
L
V
P
D
L
R
K
I
H
L
F
N
P
E
T
E
E
8
PsiBlast_PDB
80.16
38%
-110
- C1 -
2D62
8
?
A:
[7-332]
----------------------
V
K
L
I
N
I
W
K
R
F
G
--
D
--
V
T
A
V
K
D
L
S
L
E
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
R
G
Q
I
Y
I
E
D
N
L
V
---------------
A
----
D
PEKG
V
F
V
P
P
K
E
R
D
V
A
M
V
F
Q
S
Y
A
L
Y
P
H
M
T
V
Y
D
N
I
A
F
P
-
L
K
L
R
-
K
V
P
K
Q
E
I
D
K
R
V
R
E
V
A
E
M
L
G
L
T
E
L
L
N
R
K
-
P
R
E
L
S
G
G
Q
R
Q
R
V
A
L
G
R
A
I
I
R
R
P
K
V
F
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
K
M
R
A
E
L
K
K
L
Q
R
Q
L
G
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
K
G
E
L
Q
Q
V
G
T
P
D
E
V
Y
Y
K
P
V
N
T
F
V
A
G
F
I
G
S
P
P
M
--
N
F
L
D
--
A
T
I
T
D
D
G
F
L
-----
D
F
G
E
F
K
L
K
L
-
L
Q
D
Q
F
E
V
L
E
-----
E
E
N
-
M
V
G
K
E
V
I
F
G
I
R
P
E
D
V
H
D
A
S
F
--
T
--
H
I
D
V
P
E
E
N
T
V
K
A
T
V
D
I
I
E
N
L
G
G
E
K
I
V
H
L
R
R
G
N
I
S
-
F
T
A
K
F
P
K
E
S
K
V
R
E
G
D
E
-
V
S
V
V
F
D
M
K
K
I
H
I
F
R
K
D
T
E
K
A
42
PsiBlast_CBE
78.63
35%
-119
- C1 -
1OXV
15
?
D:
[2-309]
--------------------
V
R
I
I
V
K
N
V
S
K
V
F
K
--
K
GK
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
---------------
A
----
S
NGKLI-
V
P
P
E
D
R
K
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
-
L
T
N
M
-
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
V
L
N
H
F
-
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
--
I
--
N
E
L
E
--
G
----
K
-
V
T
-----
N
E
G
V
V
-
I
G
S
-
L
R
F
P
V
S
V
S
S
------------
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
K
D
VI
K
D
D
S
W
I
L
V
G
----
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
-
E
E
I
F
T
Y
S
D
H
P
I
H
S
G
E
E
-
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
N
----
43
PsiBlast_CBE
77.89
35%
-117
- C1 -
1OXV
5
?
B:
[2-309]
--------------------
V
R
I
I
V
K
N
V
S
K
V
F
K
--
K
GK
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
---------------
A
----
S
NGKLI-
V
P
P
E
D
R
K
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
-
L
T
N
M
-
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
V
L
N
H
F
-
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
--
I
--
N
E
L
E
--
G
----
K
-
V
T
-----
N
E
G
V
V
-
I
G
S
-
L
R
F
P
V
S
V
S
S
------------
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
K
D
VI
K
D
D
S
W
I
L
V
G
----
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
-
E
E
I
F
T
Y
S
D
H
P
I
H
S
G
E
E
-
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
N
----
44
PsiBlast_CBE
77.50
35%
-115
- C1 -
1OXV
7
?
A:
[2-309]
--------------------
V
R
I
I
V
K
N
V
S
K
V
F
K
--
K
GK
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
---------------
A
----
S
NGKLI-
V
P
P
E
D
R
K
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
-
L
T
N
M
-
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
V
L
N
H
F
-
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
--
I
--
N
E
L
E
--
G
----
K
-
V
T
-----
N
E
G
V
V
-
I
G
S
-
L
R
F
P
V
S
V
S
S
------------
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
K
D
VI
K
D
D
S
W
I
L
V
G
----
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
-
E
E
I
F
T
Y
S
D
H
P
I
H
S
G
E
E
-
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
N
----
47
PsiBlast_CBE
77.34
35%
-117
- C1 -
1OXU
8
?
A:
[2-309]
--------------------
V
R
I
I
V
K
N
V
S
K
V
F
K
--
K
GK
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
---------------
A
----
S
NGKLI-
V
P
P
E
D
R
K
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
-
L
T
N
M
-
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
V
L
N
H
F
-
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
--
I
--
N
E
L
E
--
G
----
K
-
V
T
-----
N
E
G
V
V
-
I
G
S
-
L
R
F
P
V
S
V
S
S
------------
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
K
D
VI
K
D
D
S
W
I
L
V
G
----
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
-
E
E
I
F
T
Y
S
D
H
P
I
H
S
G
E
E
-
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
N
----
48
PsiBlast_CBE
77.02
35%
-116
- C1 -
1OXS
20
?
C:
[2-309]
--------------------
V
R
I
I
V
K
N
V
S
K
V
F
K
--
K
GK
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
---------------
A
----
S
NGKLI-
V
P
P
E
D
R
K
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
-
L
T
N
M
-
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
V
L
N
H
F
-
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
--
I
--
N
E
L
E
--
G
----
K
-
V
T
-----
N
E
G
V
V
-
I
G
S
-
L
R
F
P
V
S
V
S
S
------------
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
K
D
VI
K
D
D
S
W
I
L
V
G
----
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
-
E
E
I
F
T
Y
S
D
H
P
I
H
S
G
E
E
-
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
-----
46
PsiBlast_CBE
77.00
35%
-119
- C1 -
1OXU
7
?
B:
[2-309]
--------------------
V
R
I
I
V
K
N
V
S
K
V
F
K
--
K
GK
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
---------------
A
----
S
NGKLI-
V
P
P
E
D
R
K
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
-
L
T
N
M
-
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
V
L
N
H
F
-
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
--
I
--
N
E
L
E
--
G
----
K
-
V
T
-----
N
E
G
V
V
-
I
G
S
-
L
R
F
P
V
S
V
S
S
------------
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
K
D
VI
K
D
D
S
W
I
L
V
G
----
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
-
E
E
I
F
T
Y
S
D
H
P
I
H
S
G
E
E
-
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
N
----
64
PsiBlast_CBE
64.92
33%
-111
- C1 -
4YMU
2
?
J:
[1-239]
---------------------
M
I
F
V
N
D
V
Y
K
N
F
G
--
S
--
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
---------------
N
NGKV
N
------
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
-
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
--
I
--
L
------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
64.35
33%
-113
- C1 -
4YMU
2
?
A:
[1-239]
---------------------
M
I
F
V
N
D
V
Y
K
N
F
G
--
S
--
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
---------------
N
NGKV
N
------
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
-
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
--
I
--
L
------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
64.23
33%
-112
- C1 -
4YMV
1
?
J:
[1-239]
---------------------
M
I
F
V
N
D
V
Y
K
N
F
G
--
S
--
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
---------------
N
NGKV
N
------
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
-
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
--
I
--
L
------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
63.83
33%
-110
- C1 -
4YMV
1
?
A:
[1-239]
---------------------
M
I
F
V
N
D
V
Y
K
N
F
G
--
S
--
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
---------------
N
NGKV
N
------
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
-
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
--
I
--
L
------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
63.68
34%
-114
- C1 -
4U00
3
?
A:
[3-241]
--------------------
P
I
I
R
I
R
N
L
H
K
W
F
G
--
P
--
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
---------------
K
----
D
DRA---
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
-
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
R
K
Y
-
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
D
V
M
R
D
L
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
--
V
--
L
H
-----------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
63.40
34%
-113
- C1 -
3C4J
4
?
B:
[24-262]
---------------------
M
I
D
V
H
Q
L
K
K
S
F
G
--
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD-----------
T
----
N
------
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
--
V
--
F
------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
62.72
34%
-112
- C1 -
2OLK
1
?
C:
[24-262]
---------------------
M
I
D
V
H
Q
L
K
K
S
F
G
--
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD-----------
T
----
N
------
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
--
V
--
F
------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
62.57
34%
-114
- C1 -
2OLJ
4
?
A:
[24-262]
---------------------
M
I
D
V
H
Q
L
K
K
S
F
G
--
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD-----------
T
----
N
------
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
--
V
--
F
------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
62.50
34%
-113
- C1 -
3C41
3
?
K:
[3-241]
---------------------
M
I
D
V
H
Q
L
K
K
S
F
G
--
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD-----------
T
----
N
------
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
--
V
--
F
------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
62.46
34%
-110
- C1 -
3C41
3
?
J:
[3-241]
---------------------
M
I
D
V
H
Q
L
K
K
S
F
G
--
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD-----------
T
----
N
------
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
--
V
--
F
------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
62.10
34%
-109
- C1 -
2OLK
2
?
B:
[24-262]
---------------------
M
I
D
V
H
Q
L
K
K
S
F
G
--
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD-----------
T
----
N
------
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
--
V
--
F
------------------------------------------------------------------------------------------------------------------------------------------------
126
HHSearch
62.03
33%
-108
* C1 *
2OLJ
4
?
A:
[22-260]
-------------------
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
--
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
---------------
K
----
A
KDTN--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
--
V
--
F
------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
61.99
34%
-110
- C1 -
2OLK
1
?
A:
[24-262]
---------------------
M
I
D
V
H
Q
L
K
K
S
F
G
--
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAK
D
-----------
T
----
N
------
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
--
V
--
F
------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
61.50
34%
-109
- C1 -
2OLK
1
?
D:
[24-262]
---------------------
M
I
D
V
H
Q
L
K
K
S
F
G
--
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD-----------
T
----
N
------
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
--
V
--
F
------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
61.12
34%
-114
- C1 -
3C4J
3
?
A:
[24-262]
---------------------
M
I
D
V
H
Q
L
K
K
S
F
G
--
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD-----------
T
----
N
------
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
--
V
--
F
------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
61.10
34%
-111
- C1 -
1B0U
4
HISP_SALTY
A:
[25-253]
--------------------------------------------
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
KDGQLKVAD
K
N
----
Q
------
L
R
L
L
R
T
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
I
Q
V
L
-
G
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
R
A
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
-
L
R
I
M
Q
Q
L
A
E
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
K
G
--
S
--
L
K
K
L
--
E
H
-----------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
60.17
34%
-105
- C1 -
2Q0H
4
?
B:
[24-262]
---------------------
M
I
D
V
H
Q
L
K
K
S
F
G
--
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD-----------
T
----
N
------
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
--
V
--
F
------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
60.13
34%
-112
- C1 -
2Q0H
4
?
A:
[24-262]
---------------------
M
I
D
V
H
Q
L
K
K
S
F
G
--
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD-----------
T
----
N
------
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
--
V
--
F
------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
60.00
34%
-108
- C1 -
2OLJ
3
?
B:
[24-262]
---------------------
M
I
D
V
H
Q
L
K
K
S
F
G
--
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD-----------
T
----
N
------
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
--
V
--
F
------------------------------------------------------------------------------------------------------------------------------------------------