@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0326: (2015-12-31 )
MTSAIAIERICMEFGTPGQGLKALDDVSLDIHANEFFTLLGPSGCGKTTLLRLIAGFEQPSSGSIRLYGEHMEGLPPFRRPVNTVFQSYALFPHMSVADNIGFGLEMQGRPRSEIDATVSRMLDLVKLPEVGKRRADQLSGGQQQRIALARALASRPKVLLLDESLSALDLKLRKEMQIELKRLQHETGITFIFVTHDQEEALTMSDRIAVMSKGKVLQVGTPSDIYEAPLNRAVADFIGETNFLEGQADADGVRLADGQRLAATTPGSGAVTLAIRPERTELAADGQLEGVLENIVYVGTDTVYHLNVAGQPGFRVRQQNRDGARCPHSPGAKVRVRIPAAAIRVLAE
Atome Classification :
(37 SA)
.........10........20........30........40........50........60....----....70..----.-----.--....80........90........100..-.....110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.--.--....-----...----250.--------...-----.--..-260-.--------..--------.------...--.-------270.......280----...--.--.---.-------.--------..290.......----300.......310..-.....320.......330.......340.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
S
A
I
A
I
E
R
I
C
M
EFGTPGQGLKALD
D
V
S
L
D
I
HA
N
E
F
F
T
L
LGPSGC
G
K
T
T
L
L
R
L
I
A
GFEQPSSG
S
I
----
R
L
Y
G
E
HME----G-----L--PPF
R
R
P
V
N
T
V
F
Q
S
Y
ALFPHMSVADNIGFG-
L
E
MQGRPR
S
E
I
D
A
T
V
S
R
M
L
D
L
VKL
P
E
V
G
K
R
R
A
D
QLSG
G
Q
Q
Q
R
I
A
L
A
R
A
L
ASRP
K
V
L
L
LDESL
S
A
L
D
L
K
L
R
K
E
M
Q
I
E
L
K
R
L
QHETG
I
T
F
I
F
V
THDQEEAL
T
M
S
D
R
I
A
V
MSKG
K
V
L
QVGT
P
S
D
I
Y
E
A
P
L
N
R
A
V
A
D
F
IG--E--T--NFLE-----GQA----DAD
G
--------
V
R
L-----A--DG-
Q
R
--
L
--------
A
A
--------T------TPG--S-------
G
A
V
T
L
A
IRPER------TEL--A--A---D-------
G
--------
Q
L
E
G
V
L
E
N
I
V
Y
V----GTD
T
V
Y
H
L
NVAGQPG-
F
R
V
R
QQNRDGARCPHSPG
A
K
V
R
V
RI
P
A
A
A
I
R
V
LAE
1
PsiBlast_PDB
95.81
40%
-117
- C2 -
1V43
-
?
A:
[13-364]
----
V
K
L
E
N
L
T
K
R
F
G
N
----
F
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
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C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
----
Y
F
G
D
R
D
V
T
----
Y
-----
L
--
P
P
K
D
R
N
I
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M
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Q
------
H
M
T
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Y
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N
I
A
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P
-
L
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K
K
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R
W
A
A
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L
L
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Y
P
A
Q
L
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G
G
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A
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Q
L
L
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T
F
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AP
E
--
M
--
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D
G
Y
L
----
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G
R
G
--------
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--
L
P
-
Q
------------
M
D
--------
L
------
L
K
D
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G
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K
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F
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P
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H
M
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GV--------
H
MK
R
T
-------
A
--------
R
L
I
G
K
V
D
F
V
E
A
L
----
G
T
D
T
I
L
H
V
K
F
-
G
D
E
L
-
V
K
V
K
L
P
----
G
H
I
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P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
F
D
K
103
HHSearch
95.57
41%
-114
- C2 -
1V43
-
?
A:
[9-366]
K
M
V
E
V
K
L
E
N
L
T
K
R
F
G
----
N
F
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
----
Y
F
G
D
R
D
V
T
----
Y
-----
L
--
P
P
K
D
R
N
I
S
M
V
F
Q
------
H
M
T
V
Y
E
N
I
A
F
P
-
L
--
K
K
F
P
K
D
E
I
D
K
R
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W
A
A
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L
L
Q
I
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E
L
L
N
R
Y
P
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Q
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Q
R
V
A
V
A
R
A
I
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P
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L
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P
L
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N
L
D
A
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L
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A
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R
A
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K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
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A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
--
A
PE
M
--
N
I
L
E
-----
V
S
V
----
G
D
G
Y
--------
L
E
------
G
--
R
G
-
F
R
--
I
--------
E
L
--------
P
QMDLLK
D
Y
V
--
G
-------
K
T
V
L
F
G
I
R
P
E
H
------
M
T
V
--
E
--
G
---
V
--------HMK
R
T
A
--
R
L
I
G
K
V
D
F
V
E
A
L
----
G
T
D
T
I
L
H
V
K
F
G
--
D
E
L
V
K
V
K
L
P
----
G
H
I
P
I
E
P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
F
D
K
2
PsiBlast_PDB
94.81
40%
-115
- C2 -
1VCI
1
?
A:
[13-364]
----
V
K
L
E
N
L
T
K
R
F
G
N
----
F
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
----
Y
F
G
D
R
D
V
T
----
Y
-----
L
--
P
P
K
D
R
N
I
S
M
V
F
Q
------
H
M
T
V
Y
E
N
I
A
F
P
-
L
--
K
K
F
P
K
D
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R
W
A
A
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L
L
Q
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L
L
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P
A
Q
L
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G
G
Q
R
Q
R
V
A
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A
R
A
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P
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L
L
M
D
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P
L
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N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
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Y
V
T
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A
M
T
M
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D
R
I
A
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N
R
G
Q
L
L
Q
I
G
S
P
T
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V
Y
L
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P
N
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F
V
A
T
F
I
G
AP
E
--
M
--
N
I
L
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V
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V
G
D
G
Y
L
----
E
G
R
G
--------
F
R
I
-----
E
--
L
P
-
Q
------------
M
D
--------
L
------
L
K
D
YV
G
-------
K
T
V
L
F
G
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R
P
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H
M
T
V
E
GV--------
H
MK
R
T
-------
A
--------
R
L
I
G
K
V
D
F
V
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A
L
----
G
T
D
T
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K
F
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L
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V
K
V
K
L
P
----
G
H
I
P
I
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P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
F
D
K
104
HHSearch
94.04
40%
-112
- C2 -
2IT1
-
?
A:
[1-351]
-
M
V
E
I
K
L
E
N
I
V
K
K
F
G
----
N
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
----
Y
F
D
E
K
D
V
T
----
E
-----
L
--
P
P
K
D
R
N
V
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
-
L
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L
R
K
A
P
R
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K
K
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A
K
M
L
H
I
D
K
L
L
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
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P
L
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N
L
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A
L
L
R
L
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R
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K
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L
G
I
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T
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Y
V
T
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D
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A
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A
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A
M
A
D
R
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A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
G
--
N
--
P
P
M
N
F
V
E
-----
A
K
V
----
E
D
G
K
--------
L
V
I
-----
T
--
E
K
-
S
K
--
L
--------
P
I
PKQY
V
E
I
V
K
------
E
T
G
--
I
-------
T
E
V
I
I
G
F
R
P
H
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------
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--
V
--
K
---
G
-------
E
GE------
G
I
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G
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Y
S
F
E
P
L
----
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R
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V
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V
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V
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P
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I
K
V
K
E
E
L
L
V
L
F
D
K
109
HHSearch
89.79
39%
-108
- C2 -
2YYZ
3
?
A:
[2-352]
--
P
S
I
R
V
V
N
L
K
K
Y
F
G
----
K
V
K
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
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L
M
L
A
G
I
Y
K
P
T
S
G
E
I
----
Y
F
D
D
V
L
V
N
----
D
-----
I
--
P
P
K
Y
R
E
V
G
M
V
F
Q
N
Y
A
L
Y
P
H
M
T
V
F
E
N
I
A
F
P
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L
R
A
R
R
I
S
K
D
E
V
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K
R
V
V
E
I
A
R
K
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L
I
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N
L
L
D
R
K
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
E
L
G
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
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F
N
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G
K
L
V
Q
Y
G
T
P
D
E
V
Y
D
S
P
K
N
M
F
V
A
S
F
I
G
--
N
--
P
P
T
N
F
L
R
-----
D
F
S
----
V
S
V
E
NK
Q
-----
T
I
L
K
----
R
--
D
D
-
V
I
--
I
--------
K
L
--------
P
E
P
V
---
D
V
K
--
L
-------
K
E
V
V
V
G
I
R
P
E
H
------
C
R
I
--
S
--
R
---
E
R
V
E
----
N
--------
S
I
P
G
V
V
Y
V
V
E
P
L
----
G
R
D
I
I
V
N
V
K
T
E
--
K
G
E
I
I
K
V
F
G
---
D
T
G
K
A
P
Q
P
G
E
N
V
F
L
V
P
D
L
R
K
I
H
L
F
N
P
4
PsiBlast_PDB
87.78
40%
-105
- C2 -
1Z47
1
?
A:
[12-347]
---
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
-
G
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
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T
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I
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R
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I
A
G
L
E
R
P
T
K
G
D
V
----
W
I
G
G
K
R
V
T
----
D
-----
L
--
P
P
Q
K
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
R
E
K
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
--
E
--
S
--
N
V
W
T
-----
R
A
V
----
Q
N
G
R
--------
I
E
V
-----
A
---
G
-
A
A
--
L
P
V
D-----
P
A
--------
V
------
S
E
G
--
S
--------
E
V
A
V
V
V
R
P
K
D
------
V
E
L
Q
P
A
--
S
---
E
-------
R
--------
E
A
H
A
Q
V
V
R
S
A
F
K
----
G
S
Y
S
A
C
W
I
R
T
K
D
G
E
V
-
W
E
V
H
V
P
S
A
D
R
H
R
W
--
S
P
G
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
--
22
PsiBlast_CBE
87.08
40%
-103
- C2 -
1Z47
1
?
B:
[14-347]
-----
T
I
E
F
V
G
V
E
K
I
Y
P
G
-
G
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
----
W
I
G
G
K
R
V
T
----
D
-----
L
--
P
P
Q
K
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
R
E
K
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
--
E
--
S
--
N
V
W
T
-----
R
A
V
----
Q
N
G
R
--------
I
E
V
-----
A
---
G
-
A
A
--
L
P
V
D-----
P
A
--------
V
------
S
E
G
--
S
--------
E
V
A
V
V
V
R
P
K
D
------
V
E
L
Q
P
A
--
S
---
E
-------
R
--------
E
A
H
A
Q
V
V
R
S
A
F
K
----
G
S
Y
S
A
C
W
I
R
T
K
D
G
E
V
-
W
E
V
H
V
P
S
A
D
R
H
R
W
--
S
P
G
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
--
110
HHSearch
86.55
37%
-112
- C2 -
3RLF
3
MALK_ECOLI
A:
[2-357]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
G
----
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
----
F
I
G
E
K
R
M
N
----
D
-----
T
--
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
K
M
--
N
F
L
P
-----
V
K
V
----
T
A
T
A
--------
I
D
Q
V
Q
V
E
L
P
MP
N
R
-
Q
Q
V
W
L
--------
P
V
ESR-----
D
------
V
Q
V
--
G
-------
A
N
M
S
L
G
I
R
P
E
H
------
L
L
P
--
S
--
D
---
I
AD-----
V
--------
I
L
E
G
E
V
Q
V
V
E
Q
L
----
G
N
E
T
Q
I
H
I
Q
I
P
--
S
I
R
Q
N
L
V
Y
R
--
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
108
HHSearch
86.22
38%
-105
- C2 -
1Z47
1
?
A:
[13-354]
--
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
---
G
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
----
W
I
G
G
K
R
V
T
----
D
-----
L
--
P
P
Q
K
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
R
E
K
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
--
E
--
S
--
N
V
W
T
-----
R
A
V
----
Q
N
G
R
--------
I
E
V
--------
A
G
-
A
A
--
L
--------
P
V
--------
D
PA----
V
S
E
--
G
-------
S
E
V
A
V
V
V
R
P
K
D
------
V
E
L
--
Q
--
P
---
A
-------
S
ER------
E
A
H
A
Q
V
V
R
S
A
F
K
----
G
S
Y
S
A
C
W
I
R
T
K
--
D
G
-
E
V
W
E
V
H
V
P
S
A
D
R
H
R
W
S
P
G
A
W
V
H
M
N
--
V
T
R
W
F
I
F
P
R
21
PsiBlast_CBE
83.94
43%
-120
- C2 -
2IT1
1
?
B:
[4-297]
----
I
K
L
E
N
I
V
K
K
F
G
N
----
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
----
Y
F
D
E
K
D
V
T
----
E
-----
L
--
P
P
K
D
R
N
V
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
-
L
E
L
R
K
A
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
D
K
L
L
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
G
--
N
P
P
M
--
N
F
V
E
-----
A
K
V
----
E
D
G
K
--------
L
V
I
-----
T
--
E
K
-
S
K
--
L
P
IPKQY
V
E
I
V
--------
K
------
E
T
G
--
I
-------
T
E
V
I
I
G
F
R
P
H
D
------
A
E
I
--
V
--
K
-----------
G
--------
E
G
E
G
I
V
G
E
V
Y
S
F
----
E
P
L
G
R
E
Q
I
V
T
V
S
V
N
D
-
S
I
V
K
V
F
A
P
E
G
E
H
F
S
F
G
E
K
V
T
I
K
V
K
E
E
L
L
V
L
F
D
K
K
T
3
PsiBlast_PDB
83.67
43%
-116
- C2 -
2IT1
-
?
A:
[4-297]
----
I
K
L
E
N
I
V
K
K
F
G
N
----
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
----
Y
F
D
E
K
D
V
T
----
E
-----
L
--
P
P
K
D
R
N
V
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
-
L
E
L
R
K
A
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
D
K
L
L
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
G
--
N
P
P
M
--
N
F
V
E
-----
A
K
V
----
E
D
G
K
--------
L
V
I
-----
T
--
E
K
-
S
K
--
L
P
IPKQY
V
E
I
V
--------
K
------
E
T
G
--
I
-------
T
E
V
I
I
G
F
R
P
H
D
------
A
E
I
--
V
--
K
-----------
G
--------
E
G
E
G
I
V
G
E
V
Y
S
F
----
E
P
L
G
R
E
Q
I
V
T
V
S
V
N
D
-
S
I
V
K
V
F
A
P
E
G
E
H
F
S
F
G
E
K
V
T
I
K
V
K
E
E
L
L
V
L
F
D
K
K
T
124
Fugue
83.41
35%
-106
- C2 -
1Z47
1
?
A:
[11-355]
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
---
G
G
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
----
W
I
G
G
K
R
V
T
----
D
-----
L
--
P
P
Q
K
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
R
E
K
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
--
E
--
S
--
N
V
W
T
-----
R
A
V
----
Q
N
G
R
--------
I
E
V
-----
A
--
G
A
-
A
L
P
-
V
--------
D
P
--------
A
------
V
S
E
--
G
-------
S
E
V
A
V
V
V
R
P
K
D
------
V
E
L
--
Q
P
A
S
---
E
-------
R
--------
E
A
H
A
Q
V
V
R
S
A
F
K
----
G
S
Y
S
A
C
W
I
R
T
K
D
G
E
V
-
W
E
V
H
V
P
S
A
D
----
R
H
R
W
S
P
G
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
5
PsiBlast_PDB
82.77
42%
-109
- C2 -
2D62
8
?
A:
[5-335]
--
A
E
V
K
L
I
N
I
W
K
R
F
G
D
----
V
T
A
V
K
D
L
S
L
E
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
R
G
Q
I
Y
I
ED
N
L
V
A
D
P
E
K
----
G
-----
V
F
V
P
P
K
E
R
D
V
A
M
V
F
Q
S
Y
A
L
Y
P
H
M
T
V
Y
D
N
I
A
F
P
-
L
K
L
R
K
V
P
K
Q
E
I
D
K
R
V
R
E
V
A
E
M
L
G
L
T
E
L
L
N
R
K
P
R
E
L
S
G
G
Q
R
Q
R
V
A
L
G
R
A
I
I
R
R
P
K
V
F
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
K
M
R
A
E
L
K
K
L
Q
R
Q
L
G
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
K
G
E
L
Q
Q
V
G
T
P
D
E
V
Y
Y
K
P
V
N
T
F
V
A
G
F
I
G
--
S
P
P
M
--
N
F
L
D
-----
A
T
I
----
T
D
D
G
FLDFGE
F
K
L
K
L
-----
L
--
Q
D
-
Q
F
E
V
L
--------
E
E
--------
E
------
N
M
V
--
G
-------
K
E
V
I
F
G
I
R
P
E
D
------
V
H
D
--
A
--
S
---
F
-------
T
--------
H
I
D
V
P
E
E
N
T
V
K
A
----
T
V
D
I
I
E
--
N
L
G
G
E
K
I
-
V
H
L
R
R
G
N
I
S
F
T
A
K
F
P
K
E
S
K
V
R
E
G
D
E
V
S
V
V
F
D
M
K
K
I
111
HHSearch
80.79
34%
-97
- C2 -
1OXX
25
?
K:
[1-352]
-
M
V
R
I
I
V
K
N
V
S
K
V
F
K
K
G
--
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
----
Y
F
D
D
R
L
V
A
----
S
NGKLI
V
--
P
P
E
D
R
K
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
-
L
T
N
M
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
V
L
N
H
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
--
E
--
I
--
N
E
L
E
-----
G
K
V
----
T
N
E
G
--------
V
V
I
--------
G
S
-
L
R
--
F
--------
P
V
---------------
S
V
S
--
S
-------
D
R
A
I
I
G
I
R
P
E
D
------
V
K
L
--
S
--
K
---
D
-------
V
IKDDSWIL
V
G
K
G
K
V
K
V
I
G
Y
Q
----
G
G
L
F
R
I
T
I
T
P
L
--
D
S
E
E
E
I
F
----
T
Y
S
D
H
P
I
H
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
105
HHSearch
79.57
36%
-100
- C2 -
3D31
2
?
A:
[1-348]
---
M
I
E
I
E
S
L
S
R
K
W
K
----
N
-
F
S
L
D
N
L
S
L
K
V
E
S
G
E
Y
F
V
I
L
G
P
T
G
A
G
K
T
L
F
L
E
L
I
A
G
F
H
V
P
D
S
G
R
I
----
L
L
D
G
K
D
V
T
----
D
-----
L
--
S
P
E
K
H
D
I
A
F
V
Y
Q
N
Y
S
L
F
P
H
M
N
V
K
K
N
L
E
F
G
-
M
R
M
K
K
I
K
---
D
P
K
R
V
L
D
T
A
R
D
L
K
I
E
H
L
L
D
R
N
P
L
T
L
S
G
G
E
Q
Q
R
V
A
L
A
R
A
L
V
T
N
P
K
I
L
L
L
D
E
P
L
S
A
L
D
P
R
T
Q
E
N
A
R
E
M
L
S
V
L
H
K
K
N
K
L
T
V
L
H
I
T
H
D
Q
T
E
A
R
I
M
A
D
R
I
A
V
V
M
D
G
K
L
I
Q
V
G
K
P
E
E
I
F
E
K
P
V
E
G
R
V
A
S
F
V
G
--
F
--
E
--
N
V
L
K
-----
G
R
V
----
I
S
A
E
--------
Q
G
L
L
R
I
--
R
--
V
G
E
V
V
--
I
--------
D
A
--------
A
G
D----
M
E
V
--
G
-------
D
Q
V
Y
A
F
L
R
P
E
N
------
I
A
L
--
S
--
K
---
S
STQSSIR
N
--------
S
L
Q
G
R
V
T
E
A
W
V
L
----
G
A
L
V
R
V
K
V
D
C
G
--
V
P
-
L
N
V
L
I
T
R
R
S
A
E
E
M
E
L
S
P
G
V
Q
I
Y
A
R
F
K
A
S
S
V
H
V
L
R
-
24
PsiBlast_CBE
78.00
41%
-101
- C2 -
3RLF
3
MALK_ECOLI
B:
[21-332]
-------------------------
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
----
F
I
G
E
K
R
M
N
----
D
-----
T
--
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
SP
K
--
M
--
N
F
L
P
-----
V
K
V
----
T
A
T
A
IDQVQ---
V
E
L
-----
P
--
M
P
-
N
R
--
Q
--------
Q
V
--------
W
------
L
P
V
--
E
SRDVQVG
A
N
M
S
L
G
I
R
P
E
H
------
L
L
P
--
S
DI
A
---
D
-------
V
--------
I
L
E
G
E
V
Q
V
V
E
Q
L
----
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
-
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
36
PsiBlast_CBE
77.72
42%
-103
- C2 -
2YYZ
3
?
A:
[16-319]
--------------------
V
K
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
I
----
Y
F
D
D
V
L
V
N
----
D
-----
I
--
P
P
K
Y
R
E
V
G
M
V
F
Q
N
Y
A
L
Y
P
H
M
T
V
F
E
N
I
A
F
P
-
L
R
A
R
R
I
S
K
D
E
V
E
K
R
V
V
E
I
A
R
K
L
L
I
D
N
L
L
D
R
K
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
E
L
G
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
Q
G
K
L
V
Q
Y
G
T
P
D
E
V
Y
D
S
P
K
N
M
F
V
A
S
F
I
G
--
N
P
P
T
--
N
F
L
R
-----
D
F
S
V
S
V
E
N
K
Q
T
--------
I
L
K
-----
R
--
D
D
-
V
I
--
I
--------
K
L
--------
P
------
E
P
V
--
D
V
KL----
K
E
V
V
V
G
I
R
P
E
H
------
C
R
I
--
S
--
R
---
E
----------------
R
V
E
N
S
I
P
G
V
V
Y
V
V
E
P
L
G
R
D
I
I
--
V
N
V
K
T
E
K
G
-
E
I
I
K
V
F
G
D
T
G
K
A
P
Q
P
G
E
N
V
F
L
V
P
D
L
R
K
I
H
L
F
N
P
E
T
34
PsiBlast_CBE
77.63
41%
-103
- C2 -
2R6G
2
MALK_ECOLI (first)
B:
[21-332]
-------------------------
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
----
F
I
G
E
K
R
M
N
----
D
-----
T
--
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
Q
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
SP
K
--
M
--
N
F
L
P
-----
V
K
V
----
T
A
T
A
IDQVQ---
V
E
L
-----
P
--
M
P
-
N
R
--
Q
--------
Q
V
--------
W
------
L
P
V
--
E
SRDVQVG
A
N
M
S
L
G
I
R
P
E
H
------
L
L
P
--
S
DI
A
---
D
-------
V
--------
I
L
E
G
E
V
Q
V
V
E
Q
L
----
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
-
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
14
PsiBlast_PDB
77.53
41%
-99
- C2 -
3PUV
5
MALK_ECOLI
A:
[21-332]
-------------------------
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
----
F
I
G
E
K
R
M
N
----
D
-----
T
--
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
SP
K
--
M
--
N
F
L
P
-----
V
K
V
----
T
A
T
A
ID
Q
V
Q
---
V
E
L
-----
P
--
M
P
-
N
R
--
Q
--------
Q
V
--------
W
------
L
P
V
--
E
SRDVQVG
A
N
M
S
L
G
I
R
P
E
H
------
L
L
P
--
S
DI
A
---
D
-------
V
--------
I
L
E
G
E
V
Q
V
V
E
Q
L
----
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
-
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
17
PsiBlast_PDB
77.49
41%
-103
- C2 -
3RLF
3
MALK_ECOLI
A:
[21-332]
-------------------------
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
----
F
I
G
E
K
R
M
N
----
D
-----
T
--
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
SP
K
--
M
--
N
F
L
P
-----
V
K
V
----
T
A
T
A
ID
Q
V
Q
---
V
E
L
-----
P
--
M
P
-
N
R
--
Q
--------
Q
V
--------
W
------
L
P
V
--
E
SRDVQVG
A
N
M
S
L
G
I
R
P
E
H
------
L
L
P
--
S
DI
A
---
D
-------
V
--------
I
L
E
G
E
V
Q
V
V
E
Q
L
----
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
-
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
71
PsiBlast_CBE
63.71
34%
-105
- C2 -
2OLK
2
?
B:
[22-262]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
----
I
I
D
G
I
N
L
K
AKDT
N
-----
L
--
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
--
V
--
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
63.58
34%
-108
- C2 -
3C4J
4
?
B:
[22-262]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
----
I
I
D
G
I
N
L
K
AKDT
N
-----
L
--
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
--
V
--
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
63.42
34%
-109
- C2 -
3C41
3
?
K:
[4-241]
----
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
----
I
I
D
G
I
N
L
K
AKDT
N
-----
L
--
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
--
V
--
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
62.28
34%
-103
- C2 -
2OLK
1
?
D:
[22-262]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
----
I
I
D
G
I
N
L
K
AKDT
N
-----
L
--
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
--
V
--
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
62.04
34%
-107
- C2 -
2OLJ
4
?
A:
[22-262]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
----
I
I
D
G
I
N
L
K
AKDT
N
-----
L
--
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
--
V
--
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
62.01
34%
-107
- C2 -
2OLK
1
?
C:
[22-262]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
----
I
I
D
G
I
N
L
K
AKDT
N
-----
L
--
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
--
V
--
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
61.19
34%
-106
- C2 -
2OLK
1
?
A:
[22-262]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
----
I
I
D
G
I
N
L
K
AK
D
T
N
-----
L
--
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
--
V
--
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
61.10
34%
-104
- C2 -
2Q0H
4
?
B:
[22-262]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
----
I
I
D
G
I
N
L
K
AKDT
N
-----
L
--
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
--
V
--
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
60.84
34%
-104
- C2 -
2Q0H
4
?
A:
[23-262]
--
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
----
I
I
D
G
I
N
L
K
AKDT
N
-----
L
--
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
--
V
--
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
60.77
34%
-103
- C2 -
2OLJ
3
?
B:
[22-262]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
----
I
I
D
G
I
N
L
K
AKDT
N
-----
L
--
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
--
V
--
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
60.48
34%
-106
- C2 -
3C41
3
?
J:
[4-241]
----
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
----
I
I
D
G
I
N
L
K
AKDT
N
-----
L
--
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
--
V
--
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
60.35
34%
-104
- C2 -
3C4J
3
?
A:
[22-262]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
----
I
I
D
G
I
N
L
K
AKDT
N
-----
L
--
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
--
V
--
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
60.05
33%
-108
- C2 -
4YMU
2
?
A:
[2-238]
----
I
F
V
N
D
V
Y
K
N
F
G
S
----
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
----
F
I
D
G
V
K
I
N
----
N
GKVN-
I
--
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
--
K
--
I
--
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
59.82
33%
-108
- C2 -
4YMV
1
?
J:
[2-238]
----
I
F
V
N
D
V
Y
K
N
F
G
S
----
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
----
F
I
D
G
V
K
I
N
----
N
GKVN-
I
--
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
--
K
--
I
--
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
59.80
33%
-109
- C2 -
4U00
3
?
A:
[3-238]
--
P
I
I
R
I
R
N
L
H
K
W
F
G
P
----
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
----
V
V
D
G
L
S
V
K
DDR-
A
-----
L
--
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
D
V
M
R
D
L
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
--
R
--
V
--
L
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
59.67
33%
-108
- C2 -
4YMU
2
?
J:
[2-238]
----
I
F
V
N
D
V
Y
K
N
F
G
S
----
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
----
F
I
D
G
V
K
I
N
----
N
GKVN-
I
--
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
--
K
--
I
--
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
59.19
33%
-105
- C2 -
4YMV
1
?
A:
[2-238]
----
I
F
V
N
D
V
Y
K
N
F
G
S
----
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
----
F
I
D
G
V
K
I
N
----
N
GKVN-
I
--
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
--
K
--
I
--
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------