@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0350: (2016-01-01 )
MARPLAMIAALGENRAIGIDNRLPWRLPADLKHFKAMTLGKPVIMGRKTWDSLGRPLPGRLNLVVSRQAGLALEGAEVFASLDAALARAEAWAQAEDADELMLIGGAQLYAEALPRAARLYLTRVGLAPEGDAFFPEIDGAAWRLASSIEHAAADDAPAYAFEVWERR
Atome Classification :
(59 SA)
--.........10........20.....-...30........------------------------40------------..-------------.......50..---.---.....60......----------------..70-.--.---------------..-..-..80........90..---......100.......110..--.-----.---...120...-...----.-130.......-140-------....-...-..150-----.----------.--.....-.--.160......-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MAR
P
L
A
M
I
A
ALGEN
R
A
IGIDNRLPWR-L
P
A
D
L
K
H
F
K
A
MTL------------------------G-------------KP-------------VIMGR
K
T
W
D
S
L---G---RPLPG
R
L
N
L
V
V
SR----------------QAGL-A--L---------------
E
G
-
A
E
-
V
F
A
S
L
D
A
A
L
A
R
A
E
A
WA---QAEDAD
E
L
M
L
IG
G
A
Q
L
Y
A
E
A
L
--
P
-----
R
---
A
A
R
L
Y
L
T
RV-GLA----P-EGDAFFPEID-
G
---------
A
A
W
R
-
L
A
S
-
S
I
E
-------H----------A--AADDA-P--
A
Y
A
F
E
VWERR-
22
PsiBlast_CBE
95.85
48%
-133
- C3 -
3IA5
2
?
B:
[3-160]
------
V
S
M
I
A
A
L
A
N
N
R
V
I
G
L
D
N
K
M
P
W
H
-
L
P
A
E
L
Q
L
F
K
R
A
T
L
------------------------
G
-------------
K
P
-------------
I
V
M
G
R
N
T
F
E
S
I
---
G
---
R
P
L
P
G
R
L
N
I
V
L
S
R
----------------
Q
-
D
Y
-
Q
--
P
---------------
E
G
-
V
T
-
V
V
A
T
L
E
D
A
V
------
V
---
A
A
G
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V
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E
L
M
I
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G
G
A
T
I
Y
N
Q
C
L
--
A
-----
A
---
A
D
R
L
Y
L
T
H
I
-
E
L
T
----
T
-
E
G
D
T
W
F
P
D
Y
E
-
Q
---------
Y
N
W
Q
-
E
I
E
-
H
E
S
-------
Y
----------
A
--
A
D
D
K
N
-
P
H
-
N
Y
R
F
S
L
L
E
R
V
-
24
PsiBlast_CBE
95.74
48%
-126
- C3 -
3IA4
2
?
C:
[3-160]
------
V
S
M
I
A
A
L
A
N
N
R
V
I
G
L
D
N
K
M
P
W
H
-
L
P
A
E
L
Q
L
F
K
R
A
T
L
------------------------
G
-------------
K
P
-------------
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V
M
G
R
N
T
F
E
S
I
---
G
---
R
P
L
P
G
R
L
N
I
V
L
S
R
----------------
Q
-
D
Y
-
Q
--
P
---------------
E
G
-
V
T
-
V
V
A
T
L
E
D
A
V
------
V
---
A
A
G
D
V
E
E
L
M
I
I
G
G
A
T
I
Y
N
Q
C
L
--
A
-----
A
---
A
D
R
L
Y
L
T
H
I
-
E
L
T
----
T
-
E
G
D
T
W
F
P
D
Y
E
-
Q
---------
Y
N
W
Q
-
E
I
E
-
H
E
S
-------
Y
----------
A
--
A
D
D
K
N
-
P
H-
N
Y
R
F
S
L
L
E
R
V
-
25
PsiBlast_CBE
95.20
48%
-125
- C3 -
3IA4
3
?
B:
[3-160]
------
V
S
M
I
A
A
L
A
N
N
R
V
I
G
L
D
N
K
M
P
W
H
-
L
P
A
E
L
Q
L
F
K
R
A
T
L
------------------------
G
-------------
K
P
-------------
I
V
M
G
R
N
T
F
E
S
I
---
G
---
R
P
L
P
G
R
L
N
I
V
L
S
R
----------------
Q
T
D
Y
-
Q
--
P
---------------
E
G
-
V
T
-
V
V
A
T
L
E
D
A
V
------
V
---
A
A
G
D
V
E
E
L
M
I
I
G
G
A
T
I
Y
N
Q
C
L
--
A
-----
A
---
A
D
R
L
Y
L
T
H
I
-
E
L
T
----
T
-
E
G
D
T
W
F
P
D
Y
E
-
Q
---------
Y
N
W
Q
-
E
I
E
-
H
E
S
-------
Y
----------
A
--
A
D
D
K
N
-
P
H
-
N
Y
R
F
S
L
L
E
R
V
-
23
PsiBlast_CBE
93.68
48%
-124
- C3 -
3IA4
2
?
D:
[3-160]
------
V
S
M
I
A
A
L
A
N
N
R
V
I
G
L
D
N
K
M
P
W
H
-
L
P
A
E
L
Q
L
F
K
R
A
T
L
------------------------
G
-------------
K
P
-------------
I
V
M
G
R
N
T
F
E
S
I
---
G
---
R
P
L
P
G
R
L
N
I
V
L
S
R
----------------
Q
T
D
Y
-
Q
--
P
---------------
E
G
-
V
T
-
V
V
A
T
L
E
D
A
V
------
V
---
A
A
G
D
V
E
E
L
M
I
I
G
G
A
T
I
Y
N
Q
C
L
--
A
-----
A
---
A
D
R
L
Y
L
T
H
I
-
E
L
T
----
T
-
E
G
D
T
W
F
P
D
Y
E
-
Q
---------
Y
N
W
Q
-
E
I
E
-
H
E
S
-------
Y
----------
A
--
A
D
D
K
N
-
P
H-
N
Y
R
F
S
L
L
E
R
V
-
103
HHSearch
93.53
44%
-123
- C3 -
3TQ8
2
?
A:
[1-161]
----
M
I
I
T
L
I
A
A
M
D
K
N
R
L
I
G
R
N
N
E
L
P
W
H
-
L
P
A
D
L
A
H
F
K
S
I
T
L
------------------------
G
-------------
K
P
-------------
I
V
M
G
R
R
T
F
D
S
I
---
G
---
K
P
L
P
H
R
R
N
I
V
I
T
Q
----------------
Q
K
N
L
-
I
--
I
---------------
E
G
-
C
D
-
I
F
Y
S
L
D
D
A
L
S
A
L
T
K
---------
E
P
E
V
I
I
I
G
G
A
R
I
F
K
E
A
L
--
P
-----
K
---
A
D
K
M
I
L
T
I
I
-
N
H
S
----
F
-
E
G
D
V
Y
F
P
E
W
N
-
D
---------
K
E
W
K
-
I
T
S
-
Q
I
K
-------
H
----------
E
--
R
D
--
N
P
Y
--
P
F
Q
F
L
E
L
R
R
L
-
1
PsiBlast_PDB
93.08
45%
-127
- C3 -
3TQ8
2
?
A:
[3-159]
------
I
T
L
I
A
A
M
D
K
N
R
L
I
G
R
N
N
E
L
P
W
H
-
L
P
A
D
L
A
H
F
K
S
I
T
L
------------------------
G
-------------
K
P
-------------
I
V
M
G
R
R
T
F
D
S
I
---
G
---
K
P
L
P
H
R
R
N
I
V
I
T
Q
----------------
Q
K
N
L
-
I
--
I
---------------
E
G
-
C
D
-
I
F
Y
S
L
D
D
A
L
------
S
---
A
L
T
K
E
P
E
V
I
I
I
G
G
A
R
I
F
K
E
A
L
--
P
-----
K
---
A
D
K
M
I
L
T
I
I
-
N
H
S
----
F
-
E
G
D
V
Y
F
P
E
W
N
-
D
---------
K
E
W
K
-
I
T
S
-
Q
I
K
-------
H
----------
E
--
R
D
--
N
-
P
---
Y
P
F
Q
F
L
E
L
R
-
4
PsiBlast_PDB
92.91
45%
-131
- C3 -
3TQB
2
?
A:
[3-159]
------
I
T
L
I
A
A
M
D
K
N
R
L
I
G
R
N
N
E
L
P
W
H
-
L
P
A
D
L
A
H
F
K
S
I
T
L
------------------------
G
-------------
K
P
-------------
I
V
M
G
R
R
T
F
D
S
I
---
G
---
K
P
L
P
H
R
R
N
I
V
I
T
Q
----------------
Q
K
N
L
-
I
--
I
---------------
E
G
-
C
D
-
I
F
Y
S
L
D
D
A
L
------
S
---
A
L
T
K
E
P
E
V
I
I
I
G
G
A
R
I
F
K
E
A
L
--
P
-----
K
---
A
D
K
M
I
L
T
I
I
-
N
H
S
----
F
-
E
G
D
V
Y
F
P
E
W
N
-
D
---------
K
E
W
K
-
I
T
S
-
Q
I
K
-------
H
-------------------------
F
Q
F
L
E
L
R
-
6
PsiBlast_PDB
92.80
48%
-131
- C3 -
3IA5
1
?
A:
[3-160]
------
V
S
M
I
A
A
L
A
N
N
R
V
I
G
L
D
N
K
M
P
W
H
-
L
P
A
E
L
Q
L
F
K
R
A
T
L
------------------------
G
-------------
K
P
-------------
I
V
M
G
R
N
T
F
E
S
I
---
G
---
R
P
L
P
G
R
L
N
I
V
L
S
------------------
T
D
Y
-
Q
--
P
---------------
E
G
-
V
T
-
V
V
A
T
L
E
D
A
V
------
V
---
A
A
G
D
V
E
E
L
M
I
I
G
G
A
T
I
Y
N
Q
C
L
--
A
-----
A
---
A
D
R
L
Y
L
T
H
I
-
E
L
T
----
T
-
E
G
D
T
W
F
P
D
Y
E
-
Q
---------
Y
N
W
Q
-
E
I
E
-
H
E
S
-------
Y
----------
A
--
A
D
D
K
N
-
P
H
-
N
Y
R
F
S
L
L
E
R
V
-
2
PsiBlast_PDB
92.49
45%
-132
- C3 -
3TQ9
2
?
A:
[3-159]
------
I
T
L
I
A
A
M
D
K
N
R
L
I
G
R
N
N
E
L
P
W
H
-
L
P
A
D
L
A
H
F
K
S
I
T
L
------------------------
G
-------------
K
P
-------------
I
V
M
G
R
R
T
F
D
S
I
---
G
---
K
P
L
P
H
R
R
N
I
V
I
T
Q
----------------
Q
K
N
L
-
I
--
I
---------------
E
G
-
C
D
-
I
F
Y
S
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D
A
L
------
S
---
A
L
T
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E
V
I
I
I
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G
A
R
I
F
K
E
A
L
--
P
-----
K
---
A
D
K
M
I
L
T
I
I
-
N
H
S
----
F
-
E
G
D
V
Y
F
P
E
W
N
-
D
---------
K
E
W
K
-
I
T
S
-
Q
I
K
-------
H
-------------------------
F
Q
F
L
E
L
R
-
21
PsiBlast_CBE
91.18
48%
-123
- C3 -
2ZZA
3
?
B:
[3-160]
------
V
S
M
I
A
A
L
A
N
N
R
V
I
G
L
D
N
K
M
P
W
H
-
L
P
A
E
L
Q
L
F
K
R
A
T
L
------------------------
G
-------------
K
P
-------------
I
V
M
G
R
N
T
F
E
S
I
---
G
---
R
P
L
P
G
R
L
N
I
V
L
S
R
----------------
Q
T
D
Y
-
Q
--
P
---------------
E
G
-
V
T
-
V
V
A
T
L
E
D
A
V
------
V
---
A
A
G
D
V
E
E
L
M
I
I
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G
A
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I
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N
Q
C
L
--
A
-----
A
---
A
D
R
L
Y
L
T
H
I
-
E
L
T
----
T
-
E
G
D
T
W
F
P
D
Y
E
-
Q
---------
Y
N
W
Q
-
E
I
E
-
H
E
S
-------
Y
----------
A
--
A
D
D
K
N
-
P
H-
N
Y
R
F
S
L
L
E
R
V
-
5
PsiBlast_PDB
91.00
48%
-121
- C3 -
2ZZA
3
?
A:
[3-160]
------
V
S
M
I
A
A
L
A
N
N
R
V
I
G
L
D
N
K
M
P
W
H
-
L
P
A
E
L
Q
L
F
K
R
A
T
L
------------------------
G
-------------
K
P
-------------
I
V
M
G
R
N
T
F
E
S
I
---
G
---
R
P
L
P
G
R
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V
L
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----------------
Q
T
D
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-
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--
P
---------------
E
G
-
V
T
-
V
V
A
T
L
E
D
A
V
------
V
---
A
A
G
D
V
E
E
L
M
I
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--
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A
---
A
D
R
L
Y
L
T
H
I
-
E
L
T
----
T
-
E
G
D
T
W
F
P
D
Y
E
-
Q
---------
Y
N
W
Q
-
E
I
E
-
H
E
S
-------
Y
----------
A
--
A
D
D
K
N
-
P
H
-
N
Y
R
F
S
L
L
E
R
V
-
3
PsiBlast_PDB
90.24
45%
-128
- C3 -
3TQA
1
?
A:
[3-159]
------
I
T
L
I
A
A
M
D
K
N
R
L
I
G
R
N
N
E
L
P
W
H
-
L
P
A
D
L
A
H
F
K
S
I
T
L
------------------------
G
-------------
K
P
-------------
I
V
M
G
R
R
T
F
D
S
I
---
G
---
K
P
L
P
H
R
R
N
I
V
I
T
Q
----------------
Q
K
N
L
-
I
--
I
---------------
E
G
-
C
D
-
I
F
Y
S
L
D
D
A
L
------
S
---
A
L
T
K
E
P
E
V
I
I
I
G
G
A
R
I
F
K
E
A
L
--
P
-----
K
---
A
D
K
M
I
L
T
I
I
-
N
H
S
----
F
-
E
G
D
V
Y
F
P
E
W
N
-
D
---------
K
E
W
K
-
I
T
S
-
Q
I
K
-------
H
----------
E
--
R
D
--
N
-
P
---
Y
P
F
Q
F
L
E
L
R
-
100
PsiBlast_CBE
87.65
44%
-114
- C3 -
4FHB
2
DYR_ECOLI
A:
[2-159]
------
I
S
L
I
A
A
L
A
V
D
R
V
I
G
M
E
N
A
M
P
W
N
-
L
P
A
D
L
A
W
F
K
R
N
T
L
------------------------
N
-------------
K
P
-------------
V
I
M
G
R
H
T
W
E
S
I
---
G
---
R
P
L
P
G
R
K
N
I
I
L
S
S
----------------
Q
P
G
T
-
D
------------------
D
R
-
V
T
-
W
V
K
S
V
D
------
E
A
I
A
---
A
C
G
D
V
P
E
I
M
V
I
G
G
G
R
V
Y
E
Q
F
L
--
P
-----
K
---
A
Q
K
L
Y
L
T
H
I
-
D
A
E
----
V
-
E
G
D
T
H
F
P
D
Y
E
-
P
---------
D
D
W
E
S
V
F
S
-
E
F
H
-------
D
----------
A
--
D
A
Q
N
S
-
H
--
S
Y
C
F
E
I
L
E
R
R
-
64
PsiBlast_CBE
87.32
40%
-122
- C3 -
4ELE
3
?
B:
[3-161]
------
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
------
E
V
F
E
---
L
C
K
N
E
E
E
I
F
I
F
G
G
A
Q
I
Y
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
--
E
V
-
F
V
E
-------
K
----------
G
--
L
T
D
E
K
-
N
PY
T
Y
Y
Y
H
V
Y
E
K
Q
-
70
PsiBlast_CBE
87.11
40%
-118
- C3 -
4ELB
3
?
C:
[3-161]
------
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
------
E
V
F
E
---
L
C
K
N
E
E
E
I
F
I
F
G
G
A
Q
I
Y
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
--
E
V
-
F
V
E
-------
K
----------
G
--
L
T
D
E
K
-
N
PY
T
Y
Y
Y
H
V
Y
E
K
Q
-
49
PsiBlast_CBE
87.09
40%
-122
- C3 -
4ELG
4
?
A:
[3-161]
------
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
------
E
V
F
E
---
L
C
K
N
E
E
E
I
F
I
F
G
G
A
Q
I
Y
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
--
E
V
-
F
V
E
-------
K
----------
G
--
L
T
D
E
K
-
N
P
Y
T
Y
Y
Y
H
V
Y
E
K
Q
-
66
PsiBlast_CBE
87.08
40%
-122
- C3 -
4ELB
4
?
G:
[3-161]
------
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
------
E
V
F
E
---
L
C
K
N
E
E
E
I
F
I
F
G
G
A
Q
I
Y
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
--
E
V
-
F
V
E
-------
K
----------
G
--
L
T
D
E
K
-
N
PY
T
Y
Y
Y
H
V
Y
E
K
Q
-
46
PsiBlast_CBE
87.08
40%
-122
- C3 -
4ELG
4
?
D:
[3-161]
------
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
------
E
V
F
E
---
L
C
K
N
E
E
E
I
F
I
F
G
G
A
Q
I
Y
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
--
E
V
-
F
V
E
-------
K
----------
G
--
L
T
D
E
K
-
N
PY
T
Y
Y
Y
H
V
Y
E
K
Q
-
97
PsiBlast_CBE
86.94
44%
-110
- C3 -
4OR7
2
?
A:
[2-159]
------
I
S
L
I
A
A
L
A
V
D
R
V
I
G
M
E
N
A
M
P
W
N
-
L
P
A
D
L
A
W
F
K
R
N
T
L
------------------------
N
-------------
K
P
-------------
V
V
M
G
R
L
T
W
E
S
I
---
G
---
R
P
L
P
G
R
K
N
I
V
I
S
S
----------------
K
P
G
--
S
--
D
---------------
D
R
-
V
Q
-
W
V
S
S
V
E
------
E
A
I
A
---
A
C
G
D
V
E
E
I
M
V
I
G
G
G
R
V
Y
E
Q
F
L
--
P
-----
K
---
A
Q
K
L
Y
L
T
H
I
-
D
A
E
----
V
-
E
G
D
T
H
F
P
D
Y
D
-
P
---------
D
E
W
E
S
V
F
S
-
E
F
H
-------
D
----------
A
--
D
A
Q
N
S
-
H
--
S
Y
C
F
E
I
L
E
R
R
-
88
PsiBlast_CBE
86.92
39%
-114
- C3 -
3JWF
2
?
A:
[9-167]
------
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
------
E
V
F
E
---
L
C
K
N
E
E
E
I
F
I
F
G
G
A
Q
I
F
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
--
E
V
-
F
V
E
-------
K
----------
G
--
L
T
D
E
K
-
N
P
Y
T
Y
Y
Y
H
V
Y
E
K
Q
-
99
PsiBlast_CBE
86.81
44%
-107
- C3 -
4I13
1
DYR_ECOLI
A:
[2-159]
------
I
S
L
I
A
A
L
A
V
D
R
V
I
G
M
E
N
A
M
P
W
N
-
L
P
A
D
L
A
W
F
K
R
N
T
L
------------------------
N
-------------
K
P
-------------
V
I
M
G
R
H
T
W
E
S
I
---
G
---
R
P
L
P
G
R
K
N
I
I
L
S
S
----------------
Q
P
G
T
-
D
------------------
D
R
-
V
T
-
W
V
K
S
V
D
------
E
A
I
A
---
A
C
G
D
V
P
E
I
M
V
I
G
G
G
R
V
Y
E
Q
F
L
--
P
-----
K
---
A
Q
K
L
Y
L
T
H
I
-
D
A
E
----
V
-
E
G
D
T
H
F
P
D
Y
E
-
P
---------
D
D
W
E
S
V
F
S
-
E
F
H
-------
D
----------
A
--
D
A
Q
N
S
-
H
--
S
Y
C
F
E
I
L
E
R
R
-
86
PsiBlast_CBE
86.59
39%
-116
- C3 -
3JWK
2
?
A:
[9-167]
------
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
------
E
V
F
E
---
L
C
K
N
E
E
E
I
F
I
F
G
G
A
Q
I
F
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
--
E
V
-
F
V
E
-------
K
----------
G
--
L
T
D
E
K
-
N
P
Y
T
Y
Y
Y
H
V
Y
E
K
Q
-
31
PsiBlast_CBE
86.43
40%
-116
- C3 -
3E0B
2
?
B:
[7-165]
------
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
------
E
V
F
E
---
L
C
K
N
E
E
E
I
F
I
F
G
G
A
Q
I
Y
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
--
E
V
-
F
V
E
-------
K
----------
G
--
L
T
D
E
K
-
N
PY
T
Y
Y
Y
H
V
Y
E
K
Q
-
85
PsiBlast_CBE
86.31
39%
-114
- C3 -
3JWK
2
?
B:
[9-167]
------
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
------
E
V
F
E
---
L
C
K
N
E
E
E
I
F
I
F
G
G
A
Q
I
F
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
--
E
V
-
F
V
E
-------
K
----------
G
--
L
T
D
E
K
-
N
PY
T
Y
Y
Y
H
V
Y
E
K
Q
-
101
PsiBlast_CBE
86.30
44%
-107
- C3 -
4EJ1
4
DYR_ECOLI
B:
[2-159]
------
I
S
L
I
A
A
L
A
V
D
R
V
I
G
M
E
N
A
M
P
W
N
-
L
P
A
D
L
A
W
F
K
R
N
T
L
------------------------
N
-------------
K
P
-------------
V
I
M
G
R
H
T
W
E
S
I
---
G
---
R
P
L
P
G
R
K
N
I
I
L
S
S
----------------
Q
P
G
T
-
D
------------------
D
R
-
V
T
-
W
V
K
S
V
D
------
E
A
I
A
---
A
C
G
D
V
P
E
I
M
V
I
G
G
G
R
V
Y
E
Q
F
L
--
P
-----
K
---
A
Q
K
L
Y
L
T
H
I
-
D
A
E
----
V
-
E
G
D
T
H
F
P
D
Y
E
-
P
---------
D
D
W
E
S
V
F
S
-
E
F
H
-------
D
----------
A
--
D
A
Q
N
S
-
H
--
S
Y
C
F
E
I
L
E
R
R
-
108
HHSearch
86.22
38%
-117
- C3 -
1KMV
3
DYR_HUMAN
A:
[1-185]
---
V
G
S
L
N
C
I
V
A
V
S
Q
N
M
G
I
G
K
N
G
D
L
P
W
P
P
L
R
N
E
F
R
Y
F
Q
R
M
T
T
------------------------
T
SSVEG
K
Q
------
N
L
-------------
V
I
M
G
K
K
T
W
F
S
I
---
P
EKN
R
P
L
K
G
R
I
N
L
V
L
S
R
----------------
E
L
K
E
-
P
--
P
---------------
Q
G
-
A
H
F
L
S
R
S
L
D
D
A
L
K
L
T
E
Q
P
E
---
L
A
N
K
V
D
M
V
W
I
V
G
G
S
S
V
Y
K
E
A
M
N
H
P
-----
G
---
H
L
K
L
F
V
T
R
I
-
M
Q
D
----
F
-
E
S
D
T
F
F
P
E
I
D
-
L
---------
E
K
Y
K
-
L
L
P
-
E
Y
P
-------
G
VLS-------
D
--
V
Q
E
E
K
G
I
--
K
Y
K
F
E
V
Y
E
K
N
-
98
PsiBlast_CBE
86.16
44%
-109
- C3 -
4I1N
1
DYR_ECOLI
A:
[2-159]
------
I
S
L
I
A
A
L
A
V
D
R
V
I
G
M
E
N
A
M
P
W
N
-
L
P
A
D
L
A
W
F
K
R
N
T
L
------------------------
N
-------------
K
P
-------------
V
I
M
G
R
H
T
W
E
S
I
---
G
---
R
P
L
P
G
R
K
N
I
I
L
S
S
----------------
Q
P
G
T
-
D
------------------
D
R
-
V
T
-
W
V
K
S
V
D
------
E
A
I
A
---
A
C
G
D
V
P
E
I
M
V
I
G
G
G
R
V
Y
E
Q
F
L
--
P
-----
K
---
A
Q
K
L
Y
L
T
H
I
-
D
A
E
----
V
-
E
G
D
T
H
F
P
D
Y
E
-
P
---------
D
D
W
E
S
V
F
S
-
E
F
H
-------
D
----------
A
--
D
A
Q
N
S
-
H
--
S
Y
C
F
E
I
L
E
R
R
-
15
PsiBlast_PDB
86.13
40%
-115
- C3 -
3JVX
2
?
A:
[9-167]
------
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
------
E
V
F
E
---
L
C
K
N
E
E
E
I
F
I
F
G
G
A
Q
I
Y
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
--
E
V
-
F
V
E
-------
K
----------
G
--
L
T
D
E
K
-
N
P
Y
T
Y
Y
Y
H
V
Y
E
K
Q
-
104
HHSearch
86.08
40%
-105
- C3 -
3S9U
2
?
A:
[2-164]
--
H
H
M
R
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
E
V
F
E
L
C
K
---------
N
E
E
E
I
F
I
F
G
G
A
Q
I
Y
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
-
E
V
F
-
V
E
K
-------
G
----------
L
--
T
D
E
K
N
P
Y
--
T
Y
Y
Y
H
V
Y
E
K
Q
-
33
PsiBlast_CBE
85.95
40%
-117
- C3 -
3JVX
2
?
B:
[9-167]
------
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
------
E
V
F
E
---
L
C
K
N
E
E
E
I
F
I
F
G
G
A
Q
I
Y
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
--
E
V
-
F
V
E
-------
K
----------
G
--
L
T
D
E
K
-
N
PY
T
Y
Y
Y
H
V
Y
E
K
Q
-
87
PsiBlast_CBE
85.90
39%
-113
- C3 -
3JWF
2
?
B:
[9-167]
------
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
------
E
V
F
E
---
L
C
K
N
E
E
E
I
F
I
F
G
G
A
Q
I
F
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
--
E
V
-
F
V
E
-------
K
----------
G
--
L
T
D
E
K
-
N
PY
T
Y
Y
Y
H
V
Y
E
K
Q
-
28
PsiBlast_CBE
85.60
40%
-117
- C3 -
3SA2
2
?
B:
[6-164]
------
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
------
E
V
F
E
---
L
C
K
N
E
E
E
I
F
I
F
G
G
A
Q
I
Y
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
--
E
V
-
F
V
E
-------
K
----------
G
--
L
T
D
E
K
-
N
PY
T
Y
Y
Y
H
V
Y
E
K
Q
-
29
PsiBlast_CBE
85.35
40%
-112
- C3 -
3SA1
2
?
B:
[6-164]
------
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
------
E
V
F
E
---
L
C
K
N
E
E
E
I
F
I
F
G
G
A
Q
I
Y
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
--
E
V
-
F
V
E
-------
K
----------
G
--
L
T
D
E
K
-
N
P
Y
T
Y
Y
Y
H
V
Y
E
K
Q
-
27
PsiBlast_CBE
85.34
40%
-112
- C3 -
3SAI
3
?
B:
[6-164]
------
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
------
E
V
F
E
---
L
C
K
N
E
E
E
I
F
I
F
G
G
A
Q
I
Y
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
--
E
V
-
F
V
E
-------
K
----------
G
--
L
T
D
E
K
-
N
PY
T
Y
Y
Y
H
V
Y
E
K
Q
-
11
PsiBlast_PDB
85.32
40%
-113
- C3 -
3SAI
6
?
A:
[6-164]
------
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
------
E
V
F
E
---
L
C
K
N
E
E
E
I
F
I
F
G
G
A
Q
I
Y
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
--
E
V
-
F
V
E
-------
K
----------
G
--
L
T
D
E
K
-
N
P
Y
T
Y
Y
Y
H
V
Y
E
K
Q
-
8
PsiBlast_PDB
84.95
40%
-113
- C3 -
3S9U
2
?
A:
[6-164]
------
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
------
E
V
F
E
---
L
C
K
N
E
E
E
I
F
I
F
G
G
A
Q
I
Y
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
--
E
V
-
F
V
E
-------
K
----------
G
--
L
T
D
E
K
-
N
P
Y
T
Y
Y
Y
H
V
Y
E
K
Q
-
10
PsiBlast_PDB
84.85
40%
-113
- C3 -
3SA2
2
?
A:
[6-164]
------
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
------
E
V
F
E
---
L
C
K
N
E
E
E
I
F
I
F
G
G
A
Q
I
Y
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
--
E
V
-
F
V
E
-------
K
----------
G
--
L
T
D
E
K
-
N
P
Y
T
Y
Y
Y
H
V
Y
E
K
Q
-
16
PsiBlast_PDB
84.73
40%
-115
- C3 -
3JWM
2
?
A:
[9-167]
------
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
------
E
V
F
E
---
L
C
K
N
E
E
E
I
F
I
F
G
G
A
Q
I
Y
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
--
E
V
-
F
V
E
-------
K
----------
G
--
L
T
D
E
K
-
N
P
Y
T
Y
Y
Y
H
V
Y
E
K
Q
-
94
PsiBlast_CBE
84.70
44%
-108
- C3 -
4OSG
5
?
C:
[2-159]
------
I
S
L
I
A
A
L
A
V
D
R
V
I
G
M
E
N
A
M
P
W
N
-
L
P
A
D
L
A
W
F
K
R
N
T
L
------------------------
N
-------------
K
P
-------------
V
V
M
G
R
L
T
W
E
S
I
---
G
---
R
P
L
P
G
R
K
N
I
V
I
S
S
----------------
K
P
G
--
S
--
D
---------------
D
R
-
V
Q
-
W
V
S
S
V
E
------
E
A
I
A
---
A
C
G
D
V
E
E
I
M
V
I
G
G
G
R
V
Y
E
Q
F
L
--
P
-----
K
---
A
Q
K
L
Y
L
T
H
I
-
D
A
E
----
V
-
E
G
D
T
H
F
P
D
Y
D
-
P
---------
D
E
W
E
S
V
F
S
-
E
F
H
-------
D
----------
A
--
D
A
Q
N
S
-
H
--
S
Y
C
F
E
I
L
E
R
R
-
7
PsiBlast_PDB
84.57
40%
-115
- C3 -
3JW3
2
?
A:
[9-167]
------
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
------
E
V
F
E
---
L
C
K
N
E
E
E
I
F
I
I
G
G
A
Q
I
Y
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
--
E
V
-
F
V
E
-------
K
----------
G
--
L
T
D
E
K
-
N
P
Y
T
Y
Y
Y
H
V
Y
E
K
Q
-
91
PsiBlast_CBE
84.49
39%
-113
* C3 *
3JW5
2
?
B:
[9-167]
------
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
------
E
V
F
E
---
L
C
K
N
E
E
E
I
F
I
F
G
G
A
Q
I
F
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
--
E
V
-
F
V
E
-------
K
----------
G
--
L
T
D
E
K
-
N
PY
T
Y
Y
Y
H
V
Y
E
K
Q
-
26
PsiBlast_CBE
84.48
40%
-117
- C3 -
3JW3
2
?
B:
[9-167]
------
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
------
E
V
F
E
---
L
C
K
N
E
E
E
I
F
I
I
G
G
A
Q
I
Y
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
--
E
V
-
F
V
E
-------
K
----------
G
--
L
T
D
E
K
-
N
PY
T
Y
Y
Y
H
V
Y
E
K
Q
-
12
PsiBlast_PDB
84.18
40%
-115
- C3 -
3E0B
2
?
A:
[7-165]
------
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
------
E
V
F
E
---
L
C
K
N
E
E
E
I
F
I
F
G
G
A
Q
I
Y
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
--
E
V
-
F
V
E
-------
K
----------
G
--
L
T
D
E
K
-
N
P
Y
T
Y
Y
Y
H
V
Y
E
K
Q
-
96
PsiBlast_CBE
84.11
44%
-112
- C3 -
4OSG
4
?
A:
[2-159]
------
I
S
L
I
A
A
L
A
V
D
R
V
I
G
M
E
N
A
M
P
W
N
-
L
P
A
D
L
A
W
F
K
R
N
T
L
------------------------
N
-------------
K
P
-------------
V
V
M
G
R
L
T
W
E
S
I
---
G
---
R
P
L
P
G
R
K
N
I
V
I
S
S
----------------
K
P
G
--
S
--
D
---------------
D
R
-
V
Q
-
W
V
S
S
V
E
------
E
A
I
A
---
A
C
G
D
V
E
E
I
M
V
I
G
G
G
R
V
Y
E
Q
F
L
--
P
-----
K
---
A
Q
K
L
Y
L
T
H
I
-
D
A
E
----
V
-
E
G
D
T
H
F
P
D
Y
D
-
P
---------
D
E
W
E
S
V
F
S
-
E
F
H
-------
D
----------
A
--
D
A
Q
N
S
-
H
--
S
Y
C
F
E
I
L
E
R
R
-
14
PsiBlast_PDB
84.07
40%
-111
- C3 -
3DAT
2
?
A:
[3-161]
------
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
------
E
V
F
E
---
L
C
K
N
E
E
E
I
F
I
F
G
G
A
Q
I
Y
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
--
E
V
-
F
V
E
-------
K
----------
G
--
L
T
D
E
K
-
N
P
Y
T
Y
Y
Y
H
V
Y
E
K
Q
-
32
PsiBlast_CBE
83.95
40%
-116
- C3 -
3JWM
2
?
B:
[9-167]
------
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
------
E
V
F
E
---
L
C
K
N
E
E
E
I
F
I
F
G
G
A
Q
I
Y
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
--
E
V
-
F
V
E
-------
K
----------
G
--
L
T
D
E
K
-
N
PY
T
Y
Y
Y
H
V
Y
E
K
Q
-
9
PsiBlast_PDB
83.64
40%
-113
- C3 -
3SA1
2
?
A:
[6-164]
------
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
------
E
V
F
E
---
L
C
K
N
E
E
E
I
F
I
F
G
G
A
Q
I
Y
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
--
E
V
-
F
V
E
-------
K
----------
G
--
L
T
D
E
K
-
N
P
Y
T
Y
Y
Y
H
V
Y
E
K
Q
-
102
PsiBlast_CBE
83.63
44%
-107
- C3 -
4EJ1
4
DYR_ECOLI
A:
[2-159]
------
I
S
L
I
A
A
L
A
V
D
R
V
I
G
M
E
N
A
M
P
W
N
-
L
P
A
D
L
A
W
F
K
R
N
T
L
------------------------
N
-------------
K
P
-------------
V
I
M
G
R
H
T
W
E
S
I
---
G
---
R
P
L
P
G
R
K
N
I
I
L
S
S
----------------
Q
P
G
T
-
D
------------------
D
R
-
V
T
-
W
V
K
S
V
D
------
E
A
I
A
---
A
C
G
D
V
P
E
I
M
V
I
G
G
G
R
V
Y
E
Q
F
L
--
P
-----
K
---
A
Q
K
L
Y
L
T
H
I
-
D
A
E
----
V
-
E
G
D
T
H
F
P
D
Y
E
-
P
---------
D
D
W
E
S
V
F
S
-
E
F
H
-------
D
----------
A
--
D
A
Q
N
S
-
H
--
S
Y
C
F
E
I
L
E
R
R
-
124
Fugue
83.46
43%
-110
- C3 -
4DFR
2
DYR_ECOLI
A:
[1-159]
-----
M
I
S
L
I
A
A
L
A
V
D
R
V
I
G
M
E
N
A
M
P
W
N
-
L
P
A
D
L
A
W
F
K
R
N
T
L
------------------------
D
-------------
K
P
-------------
V
I
M
G
R
H
T
W
E
S
I
G------
R
P
L
P
G
R
K
N
I
I
L
S
S
----------------
Q
P
--G
T
--
D
---------------
D
R
-
V
T
-
W
V
K
S
V
D
E
A
I
A
A
C
G
D
V
P
---------
E
I
M
V
I
G
G
G
R
V
Y
E
Q
F
L
--
P
-----
K
---
A
Q
K
L
Y
L
T
H
I
-
D
A
E
----
V
-
E
G
D
T
H
F
P
D
Y
E
-
P
---------
D
D
W
E
-
S
V
F
S
E
F
H
-------
D
----------
A
--
D
A
Q
N
S
-
H
--
S
Y
C
F
K
I
L
E
R
R
-
93
PsiBlast_CBE
82.89
44%
-103
- C3 -
4OSG
5
?
D:
[2-159]
------
I
S
L
I
A
A
L
A
V
D
R
V
I
G
M
E
N
A
M
P
W
N
-
L
P
A
D
L
A
W
F
K
R
N
T
L
------------------------
N
-------------
K
P
-------------
V
V
M
G
R
L
T
W
E
S
I
---
G
---
R
P
L
P
G
R
K
N
I
V
I
S
S
----------------
K
P
G
--
S
--
D
---------------
D
R
-
V
Q
-
W
V
S
S
V
E
------
E
A
I
A
---
A
C
G
D
V
E
E
I
M
V
I
G
G
G
R
V
Y
E
Q
F
L
--
P
-----
K
---
A
Q
K
L
Y
L
T
H
I
-
D
A
E
----
V
-
E
G
D
T
H
F
P
D
Y
D
-
P
---------
D
E
W
E
S
V
F
S
-
E
F
H
-------
D
----------
A
--
D
A
Q
N
S
-
H
--
S
Y
C
F
E
I
L
E
R
R
-
95
PsiBlast_CBE
82.60
44%
-103
- C3 -
4OSG
4
?
B:
[2-159]
------
I
S
L
I
A
A
L
A
V
D
R
V
I
G
M
E
N
A
M
P
W
N
-
L
P
A
D
L
A
W
F
K
R
N
T
L
------------------------
N
-------------
K
P
-------------
V
V
M
G
R
L
T
W
E
S
I
---
G
---
R
P
L
P
G
R
K
N
I
V
I
S
S
----------------
K
P
G
--
S
--
D
---------------
D
R
-
V
Q
-
W
V
S
S
V
E
------
E
A
I
A
---
A
C
G
D
V
E
E
I
M
V
I
G
G
G
R
V
Y
E
Q
F
L
--
P
-----
K
---
A
Q
K
L
Y
L
T
H
I
-
D
A
E
----
V
-
E
G
D
T
H
F
P
D
Y
D
-
P
---------
D
E
W
E
S
V
F
S
-
E
F
H
-------
D
----------
A
--
D
A
Q
N
S
-
H
--
S
Y
C
F
E
I
L
E
R
R
-
13
PsiBlast_PDB
82.36
40%
-116
- C3 -
2QK8
1
?
A:
[3-161]
------
V
S
F
M
V
A
M
D
E
N
R
V
I
G
K
D
N
N
L
P
W
R
-
L
P
S
E
L
Q
Y
V
K
K
T
T
M
------------------------
G
-------------
H
P
-------------
L
I
M
G
R
K
N
Y
E
A
I
---
G
---
R
P
L
P
G
R
R
N
I
I
V
T
R
----------------
N
E
G
Y
-
H
--
V
---------------
E
G
-
C
E
-
V
A
H
S
V
E
------
E
V
F
E
---
L
C
K
N
E
E
E
I
F
I
F
G
G
A
Q
I
Y
D
L
F
L
--
P
-----
Y
---
V
D
K
L
Y
I
T
K
I
-
H
H
A
----
F
-
E
G
D
T
F
F
P
E
M
D
-
M
---------
T
N
W
K
--
E
V
-
F
V
E
-------
K
----------
G
--
L
T
D
E
K
-
N
P
Y
T
Y
Y
Y
H
V
Y
E
K
Q
-
110
HHSearch
79.62
33%
-115
- C3 -
2W9H
2
DYR_STAAU
A:
[2-158]
-----
T
L
S
I
L
V
A
H
D
L
Q
R
V
I
G
F
E
N
Q
L
P
W
H
-
L
P
N
D
L
K
H
V
K
K
L
S
T
------------------------
G
-------------
H
T
-------------
L
V
M
G
R
K
T
F
E
S
I
---
G
---
K
P
L
P
N
R
R
N
V
V
L
T
S
----------------
D
T
S
F
-
N
--
V
---------------
E
G
-
V
D
-
V
I
H
S
I
E
D
I
Y
Q
L
------------
P
G
H
V
F
I
F
G
G
Q
T
L
F
E
E
M
I
--
D
-----
K
---
V
D
D
M
Y
I
T
V
I
-
E
G
K
----
F
-
R
G
D
T
F
F
P
P
Y
T
-
F
---------
E
D
W
E
-
V
A
S
-
S
V
E
-------
G
----------
K
--
L
D
E
K
N
T
I
--
P
H
T
F
L
H
L
I
R
K
-
113
HHSearch
77.26
35%
-92
- C3 -
3NZB
2
DYR_PNECA
X:
[3-205]
--
Q
Q
K
S
L
T
L
I
V
A
L
T
T
S
Y
G
I
G
R
S
N
S
L
P
W
K
-
L
K
K
E
I
S
Y
F
K
R
V
T
S
------------------------
F
VPTFDSFESM---
N
V
-------------
V
L
M
G
R
K
T
W
E
S
I
---
P
LQF
R
P
L
K
G
R
I
N
V
V
I
T
R
----------------
N
E
S
L
-
D
L-
G
---------------
N
G
-
I
H
-
S
A
K
S
L
D
H
A
L
E
L
L
Y
R
T
Y
GSE
S
S
V
Q
I
N
R
I
F
V
I
G
G
A
Q
L
Y
K
A
A
M
DH
P
-----
K
---
L
D
R
I
M
A
T
I
I
-
Y
K
D
----
I
-
H
C
D
V
F
F
P
L
K
F
R
D
---------
K
E
W
S
-
S
V
W
-
K
K
E
KHSDLES
W
VGTKV-----
P
HG
K
I
N
E
D
G
F
--
D
Y
E
F
E
M
W
T
R
D
-
111
HHSearch
77.10
31%
-89
- C3 -
3IX9
3
DYR_STRPN
A:
[22-186]
---
T
K
K
I
V
A
I
W
A
Q
D
E
E
G
V
I
G
K
D
N
R
L
P
W
Y
-
L
P
A
E
L
Q
H
F
K
E
T
T
L
------------------------
N
-------------
H
A
-------------
I
L
M
G
R
V
T
F
D
G
M
---
G
R--
R
L
L
P
K
R
E
T
L
I
L
T
R
----------------
N
P
E
E
-
K
--
I
---------------
D
G
-
V
A
-
T
F
H
D
V
Q
S
V
L
D
W
Y
S
A
--------
Q
E
K
N
L
Y
I
V
G
G
K
Q
I
F
Q
A
F
E
--
P
-----
Y
---
L
D
E
V
I
V
T
H
I
-
H
A
R
----
V
-
E
G
D
T
Y
F
P
A
E
F
D
L
---------
S
L
F
E
-
T
V
S
-
S
K
F
-------
Y
----------
T
--
K
D
E
K
N
P
Y
--
D
F
T
I
Q
Y
R
K
R
K
-
112
HHSearch
76.87
31%
-110
- C3 -
1AOE
2
DYR_CANAX
A:
[6-192]
-----
V
A
I
I
V
A
A
L
K
P
A
L
G
I
G
Y
K
G
K
M
P
W
R
-
L
R
K
E
I
R
Y
F
K
D
V
T
T
------------------------
R
TTKPN
T
R
------
N
A
-------------
V
I
M
G
R
K
T
W
E
S
I
---
P
QKF
R
P
L
P
D
R
L
N
I
I
L
S
R
----------------
S
Y
E
N
-
E
II
D
---------------
D
N
-
I
I
-
H
A
S
S
I
E
S
S
L
N
L
V
S
---------
D
V
E
R
V
F
I
I
G
G
A
E
I
Y
N
E
L
I
NN
S
-----
L
---
V
S
H
L
L
I
T
E
I
-
E
H
P
SPES
I
-
E
M
D
T
F
L
K
F
-
P
-
L
---------
E
S
W
T
-
K
Q
P
-
K
S
E
-------
L
Q
K
F
V
GD
T
V
L
E
D
--
D
I
K
E
G
D
F
--
T
Y
N
Y
T
L
W
T
R
K
-
116
HHSearch
75.33
32%
-91
- C3 -
3RG9
2
DRTS_TRYBB
A:
[25-239]
--
P
L
R
P
F
S
V
V
V
A
S
D
E
K
G
G
I
G
D
G
G
T
I
P
W
E
-
I
P
E
D
M
Q
Y
F
R
R
V
T
T
------------------------
N
LRGKNVKPSPS
K
R
N
A
-------------
V
V
M
G
R
K
T
W
D
S
L
---
P
PKF
R
P
L
S
N
R
L
N
V
V
L
S
R
----------------
S
A
T
K
-
E
--
Q
L
L
A
G
IPD
P
I
K
R
A
E
A
A
N
D
V
V
A
-
V
N
G
G
L
E
D
A
L
R
M
L
V
S
K
E
---
H
T
S
S
I
E
T
V
F
C
I
G
G
G
T
I
Y
K
Q
A
L
CA
P
-----
C
V
N
V
L
Q
A
I
H
R
T
V
V
-
R
P
A
----
S
N
S
C
S
V
F
F
D
I
P
A
-
A
GTKTP----
E
G
L
E
-
L
V
R
-
E
S
I
-------
T
D
E
R
-------
V
--
S
T
G
A
G
G
K
--
K
Y
Q
F
E
K
L
V
P
R
-
107
HHSearch
74.47
31%
-89
- C3 -
2BL9
2
DRTS_PLAVI
A:
[24-238]
---
A
G
T
K
N
E
P
F
S
P
R
T
F
R
G
L
G
N
K
G
T
L
P
W
K
C
N
S
V
D
M
K
Y
F
S
S
V
T
T
YVDESK
Y
E
K
L
K
W
K
R
E
R
Y
L
R
M
E
AK
L
Q
-------------
N
V
-------------
V
V
M
G
R
S
S
W
E
S
I
---
P
KQY
K
P
L
P
N
R
I
N
V
V
L
S
K
----------------
T
L
T
K
-
E
--
D
VK-------------
E
K
-
V
F
-
I
I
D
S
I
D
D
L
L
L
L
L
K
K
L
-------
K
Y
Y
K
C
F
I
I
G
G
A
Q
V
Y
R
E
C
L
S
R
N
-----
L
---
I
K
Q
I
Y
F
T
R
I
-
N
G
A
----
Y
-
P
C
D
V
F
F
P
E
F
D
-
E
---------
S
E
F
R
-
V
T
S
-
V
S
E
-------
V
--------------
Y
N
S
K
G
T
--
T
L
D
F
L
V
Y
S
K
V
-
125
Fugue
74.28
30%
-98
- C3 -
3RG9
2
DRTS_TRYBB
A:
[23-240]
R
P
P
L
R
P
F
S
V
V
V
A
S
D
E
K
G
G
I
G
D
G
G
T
I
P
W
E
-
I
P
E
D
M
Q
Y
F
R
R
V
T
T
------------------------
N
-------------
L
R
GKNVKPSPS
K
R
N
A
V
V
M
G
R
K
T
W
D
S
L
PPK
F
---
R
P
L
S
N
R
L
N
V
V
L
S
R
SAT
K
E
Q
L
L
A
G
IPD
P
I
K
R
A
E
A
-
A
--
N
---------------
D
V
-
V
A
-
V
N
G
G
L
E
D
A
L
R
M
L
V
S
K
E
---
H
T
S
S
I
E
T
V
F
C
I
G
G
G
T
I
Y
K
Q
A
L
--
C
A
P
C
V
N
V
---
L
Q
A
I
H
R
T
V
V
R
P
A
S
----
N
-
S
C
S
V
F
F
D
I
P
A
-
A
GTKTPE
G
L
E
L
V
R
E
-
S
I
T
-
D
E
R
-------
V
----------
S
--
T
G
A
G
G
-
K
--
K
Y
Q
F
E
K
L
V
P
R
N