@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0357: (2016-01-01 )
MPELPEVETTRRGIAPYLEGQRVERVIVRERRLRWPIPEDLDVRLSGQRIVSVERRAKYLLLGAEAGTLISHLGMSGSLRLVESGTPASRHEHVDIELASGMALRYTDPRRFGAMLWSLAPLEHELLRNLGPEPLTDAFAGQRLFELSRGRSMAVKPFIMDNAVVVGVGNIYASEALFAAGIDPRKPAGSISKARYLRLAEEIKRILAIAIERGGTTLRDFVGGDGQPGYFQQELFVYGRGGEFCKVCGSTLREIRLGQRASVYCPRCQR
Atome Classification :
(34 SA)
.........10........20........30......----..40..---......50........60..-.....---.70........80........90........100.......110......-.120---.....---...130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPELP
E
V
E
T
T
RRGIAPYLE
G
Q
R
V
E
R
V
I
V
R
E
RRLRWPI----PED
L
D
V
---
R
LSG
Q
R
I
V
S
V
E
RR
A
K
Y
L
L
L
G-AE
A
G
T
---
L
I
S
H
LGMSG
S
L
R
L
V
ESGTPASRH
E
H
V
D
I
E
LAS
G
M
A
L
RYT
D
P
R
R
F
G
A
M
L
W
S-LA
P
----
L
E
H
E
L
---
L
R
NLGPEP
L
T
D
A
F
A
G
Q
R
L
F
E
LSRGRSMAVK
P
F
I
MDN
A
V
V
V
G
VG
N
I
Y
A
S
E
A
L
F
AAGIDPRKPAGS
I
S
K
A
R
Y
L
R
L
A
E
E
I
K
R
I
L
A
I
A
IERGG
T
T
L
R
D
F
VGGDGQPGY
F
Q
Q
E
L
F
V
YGRG
G
E
F
C
K
V
C
G
S
T
L
R
E
I
RLGQRASVYCPRCQR
22
PsiBlast_CBE
92.73
54%
-101
- C12 -
1K82
4
FPG_ECOLI
C:
[1-268]
-
P
E
L
P
E
V
E
T
S
R
R
G
I
E
P
H
L
V
G
A
T
I
L
H
A
V
V
R
N
G
R
L
R
W
P
V
----
S
E
E
I
-
Y
---
R
L
S
D
Q
P
V
L
S
V
Q
R
R
A
K
Y
L
L
L
E
-
L
P
E
G
W
---
I
I
I
H
L
G
M
S
G
S
L
R
I
L
P
E
E
L
P
P
E
K
H
D
H
V
D
L
V
M
S
N
G
K
V
L
R
Y
T
D
P
R
R
F
G
A
W
L
W
T
-
K
E
L
----
E
G
H
N
V
---
L
T
H
L
G
P
E
P
L
S
D
D
F
N
G
E
Y
L
H
Q
K
C
A
K
K
K
T
A
I
K
P
W
L
M
D
N
K
L
V
V
G
V
G
N
I
Y
A
S
E
S
L
F
A
A
G
I
H
P
D
R
L
A
S
S
L
S
L
A
E
C
E
L
L
A
R
V
I
K
A
V
L
L
R
S
I
E
Q
G
G
T
T
L
K
--------
P
G
Y
F
A
Q
E
L
Q
V
Y
G
R
K
G
E
P
C
R
V
C
G
T
P
I
V
A
T
K
H
A
Q
R
A
T
F
Y
C
R
Q
C
Q
K
23
PsiBlast_CBE
92.44
54%
-104
- C12 -
1K82
4
FPG_ECOLI
B:
[1-268]
-
P
E
L
P
E
V
E
T
S
R
R
G
I
E
P
H
L
V
G
A
T
I
L
H
A
V
V
R
N
G
R
L
R
W
P
V
----
S
E
E
I
-
Y
---
R
L
S
D
Q
P
V
L
S
V
Q
R
R
A
K
Y
L
L
L
E
-
L
P
E
G
W
---
I
I
I
H
L
G
M
S
G
S
L
R
I
L
P
E
E
L
P
P
E
K
H
D
H
V
D
L
V
M
S
N
G
K
V
L
R
Y
T
D
P
R
R
F
G
A
W
L
W
T
-
K
E
L
----
E
G
H
N
V
---
L
T
H
L
G
P
E
P
L
S
D
D
F
N
G
E
Y
L
H
Q
K
C
A
K
K
K
T
A
I
K
P
W
L
M
D
N
K
L
V
V
G
V
G
N
I
Y
A
S
E
S
L
F
A
A
G
I
H
P
D
R
L
A
S
S
L
S
L
A
E
C
E
L
L
A
R
V
I
K
A
V
L
L
R
S
I
E
Q
G
G
T
T
L
K
--------
P
G
Y
F
A
Q
E
L
Q
V
Y
G
R
K
G
E
P
C
R
V
C
G
T
P
I
V
A
T
K
H
A
Q
R
A
T
F
Y
C
R
Q
C
Q
K
1
PsiBlast_PDB
92.16
54%
-99
- C12 -
1K82
4
FPG_ECOLI
A:
[1-268]
-
P
E
L
P
E
V
E
T
S
R
R
G
I
E
P
H
L
V
G
A
T
I
L
H
A
V
V
R
N
G
R
L
R
W
P
V
----
S
E
E
I
-
Y
---
R
L
S
D
Q
P
V
L
S
V
Q
R
R
A
K
Y
L
L
L
E
-
L
P
E
G
W
---
I
I
I
H
L
G
M
S
G
S
L
R
I
L
P
E
E
L
P
P
E
K
H
D
H
V
D
L
V
M
S
N
G
K
V
L
R
Y
T
D
P
R
R
F
G
A
W
L
W
T
-
K
E
L
----
E
G
H
N
V
---
L
T
H
L
G
P
E
P
L
S
D
D
F
N
G
E
Y
L
H
Q
K
C
A
K
K
K
T
A
I
K
P
W
L
M
D
N
K
L
V
V
G
V
G
N
I
Y
A
S
E
S
L
F
A
A
G
I
H
P
D
R
L
A
S
S
L
S
L
A
E
C
E
L
L
A
R
V
I
K
A
V
L
L
R
S
I
E
Q
G
G
T
T
L
K
--------
P
G
Y
F
A
Q
E
L
Q
V
Y
G
R
K
G
E
P
C
R
V
C
G
T
P
I
V
A
T
K
H
A
Q
R
A
T
F
Y
C
R
Q
C
Q
K
68
Fugue
92.08
55%
-95
- C12 -
1K82
4
FPG_ECOLI
A:
[1-268]
-
P
E
L
P
E
V
E
T
S
R
R
G
I
E
P
H
L
V
G
A
T
I
L
H
A
V
V
R
N
G
R
L
R
W
P
-V---
S
E
E
I
Y
R
----
L
S
D
Q
P
V
L
S
V
Q
R
R
A
K
Y
L
L
L
E
L
-
P
E
G
W
---
I
I
I
H
L
G
M
S
G
S
L
R
I
L
P
E
E
L
P
P
E
K
H
D
H
V
D
L
V
M
S
N
G
K
V
L
R
Y
T
D
P
R
R
F
G
A
W
L
W
T
K-
E
L
----
E
G
H
N
V
---
L
T
H
L
G
P
E
P
L
S
D
D
F
N
G
E
Y
L
H
Q
K
C
A
K
K
K
T
A
I
K
P
W
L
M
D
N
K
L
V
V
G
V
G
N
I
Y
A
S
E
S
L
F
A
A
G
I
H
P
D
R
L
A
S
S
L
S
L
A
E
C
E
L
L
A
R
V
I
K
A
V
L
L
R
S
I
E
Q
G
G
T
T
L
--------
K
P
G
Y
F
A
Q
E
L
Q
V
Y
G
R
K
G
E
P
C
R
V
C
G
T
P
I
V
A
T
K
H
A
Q
R
A
T
F
Y
C
R
Q
C
Q
K
21
PsiBlast_CBE
91.47
54%
-99
- C12 -
1K82
4
FPG_ECOLI
D:
[1-268]
-
P
E
L
P
E
V
E
T
S
R
R
G
I
E
P
H
L
V
G
A
T
I
L
H
A
V
V
R
N
G
R
L
R
W
P
V
----
S
E
E
I
-
Y
---
R
L
S
D
Q
P
V
L
S
V
Q
R
R
A
K
Y
L
L
L
E
-
L
P
E
G
W
---
I
I
I
H
L
G
M
S
G
S
L
R
I
L
P
E
E
L
P
P
E
K
H
D
H
V
D
L
V
M
S
N
G
K
V
L
R
Y
T
D
P
R
R
F
G
A
W
L
W
T
-
K
E
L
----
E
G
H
N
V
---
L
T
H
L
G
P
E
P
L
S
D
D
F
N
G
E
Y
L
H
Q
K
C
A
K
K
K
T
A
I
K
P
W
L
M
D
N
K
L
V
V
G
V
G
N
I
Y
A
S
E
S
L
F
A
A
G
I
H
P
D
R
L
A
S
S
L
S
L
A
E
C
E
L
L
A
R
V
I
K
A
V
L
L
R
S
I
E
Q
G
G
T
T
L
K
--------
P
G
Y
F
A
Q
E
L
Q
V
Y
G
R
K
G
E
P
C
R
V
C
G
T
P
I
V
A
T
K
H
A
Q
R
A
T
F
Y
C
R
Q
C
Q
K
78
HHSearch
90.66
54%
-90
- C12 -
1K82
4
FPG_ECOLI
A:
[1-268]
-
P
E
L
P
E
V
E
T
S
R
R
G
I
E
P
H
L
V
G
A
T
I
L
H
A
V
V
R
N
G
R
L
R
W
P
-----
V
S
E
E
I
Y
---
R
L
S
D
Q
P
V
L
S
V
Q
R
R
A
K
Y
L
L
L
E
-
L
P
E
G
W
---
I
I
I
H
L
G
M
S
G
S
L
R
I
L
P
E
E
L
P
P
E
K
H
D
H
V
D
L
V
M
S
N
G
K
V
L
R
Y
T
D
P
R
R
F
G
A
W
L
W
T
-
K
E
L
----
E
G
H
N
V
---
L
T
H
L
G
P
E
P
L
S
D
D
F
N
G
E
Y
L
H
Q
K
C
A
K
K
K
T
A
I
K
P
W
L
M
D
N
K
L
V
V
G
V
G
N
I
Y
A
S
E
S
L
F
A
A
G
I
H
P
D
R
L
A
S
S
L
S
L
A
E
C
E
L
L
A
R
V
I
K
A
V
L
L
R
S
I
E
Q
G
G
T
T
L
K
--------
P
G
Y
F
A
Q
E
L
Q
V
Y
G
R
K
G
E
P
C
R
V
C
G
T
P
I
V
A
T
K
H
A
Q
R
A
T
F
Y
C
R
Q
C
Q
K
12
PsiBlast_PDB
85.32
40%
-85
- C12 -
2F5Q
3
?
A:
[2-274]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
-----
R
I
F
W
P
N
IIRH
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
-
L
D
R
D
A
---
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
-
H
V
-
Y
A
K
----
E
E
A
D
R
RPP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
19
PsiBlast_PDB
85.03
40%
-84
- C12 -
3GPY
3
?
A:
[1-273]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
-----
R
I
F
W
P
N
IIRH
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
-
L
D
R
D
A
---
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
-
H
V
-
Y
A
K
----
E
E
A
D
R
RPP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
11
PsiBlast_PDB
84.75
40%
-86
- C12 -
1R2Z
3
?
A:
[2-274]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
-----
R
I
F
W
P
N
IIRH
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
-
L
D
R
D
A
---
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
-
H
V
-
Y
A
K
----
E
E
A
D
R
RPP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
10
PsiBlast_PDB
84.53
40%
-85
- C12 -
1R2Y
3
?
A:
[2-274]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
-----
R
I
F
W
P
N
IIRH
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
-
L
D
R
D
A
---
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
-
H
V
-
Y
A
K
----
E
E
A
D
R
RPP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
6
PsiBlast_PDB
83.77
40%
-89
- C12 -
1L2D
3
?
A:
[2-274]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
-----
R
I
F
W
P
N
IIRH
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
-
L
D
R
D
A
---
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
-
H
V
-
Y
A
K
----
E
E
A
D
R
RPP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
--------------
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
20
PsiBlast_PDB
83.75
40%
-85
- C12 -
3GQ4
4
?
A:
[1-273]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
-----
R
I
F
W
P
N
IIRH
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
-
L
D
R
D
A
---
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
-
H
V
-
Y
A
K
----
E
E
A
D
R
RPP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
40
PsiBlast_CBE
83.45
39%
-85
- C12 -
3JR5
4
?
A:
[1-273]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
-----
R
I
F
W
P
N
IIRH
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
-
L
D
R
D
A
---
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
-
H
V
-
Y
A
K
----
E
E
A
D
R
RPP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
C
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
13
PsiBlast_PDB
83.42
40%
-86
- C12 -
2F5S
3
?
A:
[2-274]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
-----
R
I
F
W
P
N
IIRH
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
-
L
D
R
D
A
---
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
-
H
V
-
Y
A
K
----
E
E
A
D
R
RPP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
41
PsiBlast_CBE
83.11
39%
-88
- C12 -
3JR4
3
?
A:
[1-273]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
-----
R
I
F
W
P
N
IIRH
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
-
L
D
R
D
A
---
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
-
H
V
-
Y
A
K
----
E
E
A
D
R
RPP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
C
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
----------
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
30
PsiBlast_CBE
83.00
40%
-94
- C12 -
3U6S
3
?
A:
[1-273]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
-----
R
I
F
W
P
N
IIRH
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
-
L
D
R
D
A
---
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
-
H
V
-
Y
A
K
----
E
E
A
D
R
RPP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
---------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
8
PsiBlast_PDB
82.94
40%
-96
- C12 -
2F5O
4
?
A:
[2-274]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
-----
R
I
F
W
P
N
IIRH
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
-
L
D
R
D
A
---
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
-
H
V
-
Y
A
K
----
E
E
A
D
R
RPP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
---------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
32
PsiBlast_CBE
82.90
40%
-95
- C12 -
3U6P
3
?
A:
[1-273]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
-----
R
I
F
W
P
N
IIRH
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
-
L
D
R
D
A
---
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
-
H
V
-
Y
A
K
----
E
E
A
D
R
RPP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
---------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
5
PsiBlast_PDB
82.82
40%
-89
- C12 -
1L2C
3
?
A:
[2-274]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
-----
R
I
F
W
P
N
IIRH
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
-
L
D
R
D
A
---
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
-
H
V
-
Y
A
K
----
E
E
A
D
R
RPP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
--------------
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
16
PsiBlast_PDB
82.75
40%
-96
- C12 -
3SAV
3
?
A:
[1-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
-----
R
I
F
W
P
N
IIRH
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
-
L
D
R
D
A
---
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
-
H
V
-
Y
A
K
----
E
E
A
D
R
RPP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
---------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
14
PsiBlast_PDB
82.65
40%
-97
- C12 -
3SAR
7
?
A:
[1-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
-----
R
I
F
W
P
N
IIRH
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
-
L
D
R
D
A
---
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
-
H
V
-
Y
A
K
----
E
E
A
D
R
RPP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
--------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
4
PsiBlast_PDB
81.95
40%
-89
- C12 -
1L2B
4
?
A:
[2-274]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
-----
R
I
F
W
P
N
IIRH
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
-
L
D
R
D
A
---
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
-
H
V
-
Y
A
K
----
E
E
A
D
R
RPP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
---------
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
28
PsiBlast_CBE
81.74
40%
-92
- C12 -
3SAS
3
?
A:
[1-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
-----
R
I
F
W
P
N
IIRH
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
-
L
D
R
D
A
---
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
A
K
F
G
T
M
-
H
V
-
Y
A
K
----
E
E
A
D
R
RPP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
--------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
49
PsiBlast_CBE
80.30
35%
-77
- C12 -
3C58
4
FPG_LACLC
A:
[1-270]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
I
S
I
E
A
T
Y
P
R
M
V
L
T
G
----
F
E
Q
L
K
K
---
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
D
F
R
---
L
I
S
H
L
R
M
E
G
K
Y
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
Q
-
L
I
Y
A
D
V
R
K
F
G
T
--
W
E
-
L
I
S
TDQ
V
L
P
Y
F
L
---
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
I
K
L
G
G
S
S
I
R
---
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
R
C
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
51
PsiBlast_CBE
80.27
35%
-77
- C12 -
2XZF
4
FPG_LACLC
A:
[1-270]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
I
S
I
E
A
T
Y
P
R
M
V
L
T
G
----
F
E
Q
L
K
K
---
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
D
F
R
---
L
I
S
H
L
R
M
E
G
K
Y
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
Q
-
L
I
Y
A
D
V
R
K
F
G
T
--
W
E
-
L
I
S
TDQ
V
L
P
Y
F
L
---
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
I
K
L
G
G
S
------
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
R
C
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
46
PsiBlast_CBE
80.16
35%
-84
- C12 -
4CIS
4
?
A:
[2-271]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
I
S
I
E
A
T
Y
P
R
M
V
L
T
G
----
F
E
Q
L
K
K
---
E
L
T
G
K
I
I
Q
G
I
I
R
R
G
K
Y
L
I
F
E
I
G
D
D
F
R
---
L
I
S
H
L
R
M
E
G
K
Y
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
S
D
G
Q
-
L
I
Y
A
D
V
R
K
F
G
T
--
W
E
-
L
I
S
TDQ
V
L
P
Y
F
L
---
N
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
A
N
Q
L
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
I
K
L
G
G
S
S
I
---------
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
R
C
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
F
C
Q
Q
44
PsiBlast_CBE
80.10
35%
-82
- C12 -
1TDZ
4
FPG_LACLC
A:
[3-271]
--
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
I
S
I
E
A
T
Y
P
R
M
V
L
T
G
----
F
E
Q
L
K
K
---
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
D
F
R
---
L
I
S
H
L
R
M
E
G
K
Y
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
Q
-
L
I
Y
A
D
V
R
K
F
G
T
--
W
E
-
L
I
S
TDQ
V
L
P
Y
F
L
---
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
I
K
L
G
G
S
S
I
------
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
R
C
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
50
PsiBlast_CBE
79.36
35%
-76
- C12 -
2XZU
4
FPG_LACLC
A:
[1-270]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
I
S
I
E
A
T
Y
P
R
M
V
L
T
G
----
F
E
Q
L
K
K
---
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
D
F
R
---
L
I
S
H
L
R
M
E
G
K
Y
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
Q
-
L
I
Y
A
D
V
R
K
F
G
T
--
W
E
-
L
I
S
TDQ
V
L
P
Y
F
L
---
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
I
K
L
G
G
S
------
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
R
C
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
52
PsiBlast_CBE
79.33
35%
-77
- C12 -
1XC8
4
FPG_LACLC
A:
[1-270]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
I
S
I
E
A
T
Y
P
R
M
V
L
T
G
----
F
E
Q
L
K
K
---
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
D
F
R
---
L
I
S
H
L
R
M
E
G
K
Y
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
Q
-
L
I
Y
A
D
V
R
K
F
G
T
--
W
E
-
L
I
S
TDQ
V
L
P
Y
F
L
---
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
I
K
L
G
G
S
S
I
R
T
Y
-
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
R
C
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
53
PsiBlast_CBE
79.16
35%
-75
- C12 -
1PM5
6
FPG_LACLC
A:
[1-270]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
I
S
I
E
A
T
Y
P
R
M
V
L
T
G
----
F
E
Q
L
K
K
---
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
D
F
R
---
L
I
S
H
L
R
M
E
G
K
Y
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
Q
-
L
I
Y
A
D
V
R
K
F
G
T
--
W
E
-
L
I
S
TDQ
V
L
P
Y
F
L
---
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
I
K
L
G
G
S
S
I
R
T
Y
-
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
R
C
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
54
PsiBlast_CBE
79.11
35%
-79
- C12 -
1PJI
7
FPG_LACLC
A:
[1-270]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
I
S
I
E
A
T
Y
P
R
M
V
L
T
G
----
F
E
Q
L
K
K
---
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
D
F
R
---
L
I
S
H
L
R
M
E
G
K
Y
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
Q
-
L
I
Y
A
D
V
R
K
F
G
T
--
W
E
-
L
I
S
TDQ
V
L
P
Y
F
L
---
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
I
K
L
G
G
S
S
-----
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
R
C
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
60
PsiBlast_CBE
78.12
35%
-79
- C12 -
1PJJ
6
FPG_LACLC
A:
[2-270]
--
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
I
S
I
E
A
T
Y
P
R
M
V
L
T
G
----
F
E
Q
L
K
K
---
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
---
E
I
G
D
D
F
R
L
I
S
H
L
R
M
E
G
K
Y
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
Q
-
L
I
Y
A
D
V
R
K
F
G
T
--
W
E
-
L
I
S
TDQ
V
L
P
Y
F
L
---
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
I
K
L
G
G
S
S
I
R
T
Y
-
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
R
C
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
61
PsiBlast_CBE
78.04
35%
-82
- C12 -
1NNJ
5
FPG_LACLC
A:
[2-270]
--
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
I
S
I
E
A
T
Y
P
R
M
V
L
T
G
----
F
E
Q
L
K
K
---
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
---
E
I
G
D
D
F
R
L
I
S
H
L
R
M
E
G
K
Y
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
Q
-
L
I
Y
A
D
V
R
K
F
G
T
--
W
E
-
L
I
S
TDQ
V
L
P
Y
F
L
---
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
I
K
L
G
G
S
S
I
-----
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
R
C
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
55
PsiBlast_CBE
76.85
35%
-78
- C12 -
4PCZ
4
FPG_LACLC
A:
[1-270]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
I
S
I
E
A
T
Y
P
R
M
V
L
T
G
----
F
E
Q
L
K
K
---
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
---
E
I
G
D
D
F
R
L
I
S
H
L
R
M
E
G
K
Y
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
Q
-
L
I
Y
A
D
V
R
K
F
G
T
--
W
E
-
L
I
S
TDQ
V
L
P
Y
F
L
---
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
I
K
L
G
G
S
S
I
R
T
Y
-
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
G
C
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q