@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0372: (2016-01-02 )
MAARKVQITMKTPARRRVGLLLASLCLPLFAQAAETQPTHEFSLDNGLKVIVREDHRAPVVVSQLWYRIGSSYETPGLTGLSHALEHMMFKGSRKLGPGEASRVLRDLGAEENAFTTDDYTAYYQVLARDRLPVALEMEADRMAHLSLPVDQFKSEIEVIKEERRLRTDDNPNALAFERFKAAAYPASGYHTPTIGWMADLQRMTIDDLRHWYESWYAPNNATLVVVGDVTADEVKTLAKRYFGEIPWRQLPPARKPLELAEPGERRLKLYVRTQLPNLIMGFNVPSLGSSENPREVNALRLIGALLDGGYSARLASRLERGEELVAGASTYYDAFNRGDSLFVLSATPNVQKGKTLEQVEAGLWKQLDDLKQNPPSAAEIERVRAQMIAGMVYEKDSIAAQASSIGQLESVGLSWKLIDQDLEALKAVTPDDIQKAARTYFTPSRLTLAQVLPVKAEEKEARHE
Atome Classification :
(20 SA)
.........10........20........30........40........50.......--.60........70........80........90....----.-.-.-.100.......110----........120.......---130.........140....---...150.......160.......170.......180.......190.------......200.------.----.-------.-------...210.......220.......230.......240....-...250....-.-..--260.-..--.--..-.-.270.--......280.......---290......------.300.......-------310---------.----....-----....320-.---.......330...--.-.-..-340.....--..350.......360.......370.--.......380.......390..-.-----.-...--400.......410.---......420..-.---....430.......440.---------......450.....--..460...----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAA
R
K
V
Q
I
T
MKTP
A
R
R
R
V
G
L
L
L
A
S
L
C
L
P
L
F
A
Q
A
AETQPT
H
E
FSLDN
G
L
K
V
I
V
REDHRA--
P
V
V
V
S
Q
L
W
Y
R
IGSSYETPG
L
T
G
L
S
H
A
L
E
H
M
M
F
KGSRK----L-G-
P
-
G
E
A
S
R
V
L
R
D
LGAE-----ENAFTT
D
D
Y
T
A
Y
Y
Q
V
L
A
R---D--RL
P
V
A
L
E
MEAD
R
M
AHL---SL
P
V
D
Q
F
K
S
E
I
E
V
I
K
E
E
R
RLRTDDNPN
A
L
A
F
E
R
F
K
AAAYPASGYHTP------
T
I
G
W
M
A
D
L
Q
R
------
M
----
T
-------
I
-------
D
D
L
R
H
W
Y
E
S
WYAPN
N
A
T
L
V
V
V
GDV
T
A
D
E
V
K
T
L
A
K
R
Y
FGEI-
P
W
R
QLPPARK-P-LE--LA-E-PG--E--
R
R
-
L
-
K
L
Y
V
R--TQLP
N
L
I
MGFNVPSLG---SSENP
R
E
V
N
------
A
L
R
L
I
G
A
L
LDG-------
G
-----------
Y
----
S
A
R
L
-----
A
S
R
L
ER--G---
E
E
L
VAG
A
S
T
Y
Y
D
A--F-N-RG-D
S
L
F
V
L
SA--TPNVQKGK
T
L
E
Q
V
E
A
G
L
W
K
Q
L
D
D
-
L
K--QNPP
S
A
A
E
I
E
R
V
R
A
Q
M
I
A
G
M
VY-E-----K-
D
S
I
--
A
A
Q
A
S
SIG
Q
L
E
SVG---
L
S
W
K
L
I
D
Q
D
L
E
-
A
---
L
KAV
T
P
D
D
I
Q
K
A
A
R
T
YFT---------P
S
R
L
T
L
A
Q
VLPVKA--
E
E
K
EARHE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
97.57
100%
-81
- C1 -
4NNZ
2
?
A:
[6-423]
-------------------------------------
P
T
H
E
F
S
L
D
N
G
L
K
V
I
V
R
E
D
H
R
A
--
P
V
V
V
S
Q
L
W
Y
R
I
G
S
S
Y
E
T
P
G
L
T
G
L
S
H
A
L
E
H
M
M
F
---------------------------
E
-----
E
N
A
F
T
T
D
D
Y
T
A
Y
Y
Q
V
L
A
R
---
D
--
R
L
P
V
A
L
E
M
E
A
D
R
M
A
H
L
---
S
L
P
V
D
Q
F
K
S
E
I
E
V
I
K
E
E
R
R
L
R
T
D
D
N
P
N
A
L
A
F
E
R
F
K
A
A
A
Y
P
A
S
G
Y
H
T
P
------
T
I
G
W
M
A
D
L
Q
R
------
M
----
T
-------
I
-------
D
D
L
R
H
W
Y
E
S
W
Y
A
P
N
N
A
T
L
V
V
V
G
D
V
T
A
D
E
V
K
T
L
A
K
R
Y
F
G
E
I
-
P
W
R
Q
L
P
P
A
R
K
-
P
-
L
E
--
L
A
-
E
-
P
G
--
E
--
R
R
-
L
-
K
L
Y
V
R
--
T
Q
L
P
N
L
I
M
G
F
N
V
P
S
L
G
---
S
S
E
N
P
R
E
V
N
------
A
L
R
L
I
G
A
L
L
D
G
-------
G
-----------
Y
----
S
A
R
L
-----
A
S
R
L
E
R
--
G
---
E
E
L
V
A
G
A
S
T
Y
Y
D
A
--
F
-
N
-
R
G
-
D
S
L
F
V
L
S
A
--
T
P
N
V
Q
K
G
K
T
L
E
Q
V
E
A
G
L
W
K
Q
L
D
D
-
L
K
--
Q
N
P
P
S
A
A
E
I
E
R
V
R
A
Q
M
I
A
G
M
V
Y
-
E
-----
K
-
D
S
I
--
A
A
Q
A
S
S
I
G
Q
L
E
S
V
G
---
L
S
W
K
L
I
D
Q
D
L
E
-
A
---
L
K
A
V
T
P
D
D
I
Q
K
A
A
R
T
Y
F
T
---------
P
S
R
L
T
L
A
Q
V
L
P
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
81.80
44%
-64
- C1 -
3AMI
-
?
A:
[33-450]
--------------------------------------
T
F
E
T
T
L
P
N
G
L
K
V
V
V
R
E
D
H
R
A
--
P
T
L
V
H
M
V
W
Y
R
V
G
S
M
D
E
T
T
G
T
T
G
V
A
H
A
L
E
H
M
M
F
K
G
T
K
D
----
V
-
G
-
P
-
G
E
F
S
K
R
V
A
A
M
G
G
R
-----
D
N
A
F
T
T
R
D
Y
T
A
Y
Y
Q
Q
V
P
S
---
S
--
R
L
S
D
V
M
G
L
E
A
D
R
M
A
N
L
---
V
V
D
D
E
L
F
K
K
E
I
Q
V
I
A
E
E
R
R
W
R
T
D
D
K
P
R
S
K
A
Y
E
A
L
M
A
A
S
Y
V
A
H
P
Y
R
V
P
------
V
I
G
W
M
N
D
I
Q
N
------
M
----
T
-------
A
-------
Q
D
V
R
D
W
Y
K
R
W
Y
G
P
N
N
A
T
V
V
V
V
G
D
V
E
H
E
A
V
F
R
L
A
E
Q
T
Y
G
K
L
-
A
R
V
E
A
P
A
R
K
Q
-
Q
-
G
E
--
P
Q
-
Q
-
A
G
--
V
--
R
R
-
V
-
T
V
K
A
P
--
A
E
L
P
Y
L
A
L
A
W
H
V
P
A
I
V
---
D
L
D
K
S
R
D
A
Y
------
A
L
E
I
L
A
A
V
L
D
G
-------
Y
-----------
D
----
G
A
R
M
-----
T
R
Q
L
V
R
--
G
---
N
K
H
A
V
S
A
G
A
G
Y
D
S
--
L
-
S
-
R
G
Q
Q
G
L
F
I
L
E
G
--
V
P
S
--
K
G
V
T
I
A
Q
L
E
T
D
L
R
A
Q
V
R
D
-
I
A
--
A
K
G
V
T
E
A
E
L
S
R
V
K
S
Q
M
V
A
G
K
V
Y
-
E
-----
Q
-
D
S
L
--
M
G
Q
A
T
Q
I
G
G
L
E
V
L
G
---
L
S
W
R
D
D
D
R
F
Y
Q
-
Q
---
L
R
S
V
T
A
A
E
V
K
A
A
A
A
R
L
L
T
---------
D
D
T
L
T
V
A
N
L
V
P
L
P
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
81.18
44%
-65
- C1 -
3AMI
-
?
A:
[30-450]
-----------------------------------
A
A
S
T
F
E
T
T
L
P
N
G
L
K
V
V
V
R
E
D
H
R
A
--
P
T
L
V
H
M
V
W
Y
R
V
G
S
M
D
E
T
T
G
T
T
G
V
A
H
A
L
E
H
M
M
F
K
G
T
K
D
----
V
-
G
-
P
-
G
E
F
S
K
R
V
A
A
M
G
G
R
-----
D
N
A
F
T
T
R
D
Y
T
A
Y
Y
Q
Q
V
P
S
---
S
--
R
L
S
D
V
M
G
L
E
A
D
R
M
A
N
L
---
V
V
D
D
E
L
F
K
K
E
I
Q
V
I
A
E
E
R
R
W
R
T
D
D
K
P
R
S
K
A
Y
E
A
L
M
A
A
S
Y
V
A
H
P
Y
R
V
P
------
V
I
G
W
M
N
D
I
Q
N
------
M
----
T
-------
A
-------
Q
D
V
R
D
W
Y
K
R
W
Y
G
P
N
N
A
T
V
V
V
V
G
D
V
E
H
E
A
V
F
R
L
A
E
Q
T
Y
G
K
L
-
A
R
V
E
A
P
A
R
K
Q
-
Q
-
G
E
--
P
Q
-
Q
-
A
G
--
V
--
R
R
-
V
-
T
V
K
A
P
--
A
E
L
P
Y
L
A
L
A
W
H
V
P
A
I
V
DLD
K
---
S
R
D
A
Y
------
A
L
E
I
L
A
A
V
L
D
G
-------
Y
-----------
D
----
G
A
R
M
-----
T
R
Q
L
V
R
--
G
---
N
K
H
A
V
S
A
G
A
G
Y
D
S
--
L
-
S
R
G
Q
-
Q
G
L
F
I
L
E
G
--
V
P
S
K
G
V
--
T
I
A
Q
L
E
T
D
L
R
A
Q
V
R
D
-
I
A
--
A
K
G
V
T
E
A
E
L
S
R
V
K
S
Q
M
V
A
G
K
V
Y
-
E
-----
Q
-
D
S
L
--
M
G
Q
A
T
Q
I
G
G
L
E
V
L
G
---
L
S
W
R
D
D
D
R
F
Y
Q
-
Q
---
L
R
S
V
T
A
A
E
V
K
A
A
A
A
R
L
L
T
---------
D
D
T
L
T
V
A
N
L
V
P
L
P
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
80.82
44%
-62
- C1 -
3AMJ
1
?
A:
[7-424]
--------------------------------------
T
F
E
T
T
L
P
N
G
L
K
V
V
V
R
E
D
H
R
A
--
P
T
L
V
H
M
V
W
Y
R
V
G
S
M
D
E
T
T
G
T
T
G
V
A
H
A
L
E
H
M
M
F
K
G
T
K
D
----
V
-
G
-
P
-
G
E
F
S
K
R
V
A
A
M
G
G
R
-----
D
N
A
F
T
T
R
D
Y
T
A
Y
Y
Q
Q
V
P
S
---
S
--
R
L
S
D
V
M
G
L
E
A
D
R
M
A
N
L
---
V
V
D
D
E
L
F
K
K
E
I
Q
V
I
A
E
E
R
R
W
R
T
D
D
K
P
R
S
K
A
Y
E
A
L
M
A
A
S
Y
V
A
H
P
Y
R
V
P
------
V
I
G
W
M
N
D
I
Q
N
------
M
----
T
-------
A
-------
Q
D
V
R
D
W
Y
K
R
W
Y
G
P
N
N
A
T
V
V
V
V
G
D
V
E
H
E
A
V
F
R
L
A
E
Q
T
Y
G
K
L
-
A
R
V
E
A
P
A
R
K
Q
-
Q
-
G
E
--
P
Q
-
Q
-
A
G
--
V
--
R
R
-
V
-
T
V
K
A
P
--
A
E
L
P
Y
L
A
L
A
W
H
V
P
A
I
V
---
D
L
D
K
S
R
D
A
Y
------
A
L
E
I
L
A
A
V
L
D
G
-------
Y
-----------
D
----
G
A
R
M
-----
T
R
Q
L
V
R
--
G
---
N
K
H
A
V
S
A
G
A
G
Y
D
S
--
L
-
S
-
R
G
Q
Q
G
L
F
I
L
E
G
--
V
P
S
--
K
G
V
T
I
A
Q
L
E
T
D
L
R
A
Q
V
R
D
-
I
A
--
A
K
G
V
T
E
A
E
L
S
R
V
K
S
Q
M
V
A
G
K
V
Y
-
E
-----
Q
-
D
S
L
--
M
G
Q
A
T
Q
I
G
G
L
E
V
L
G
---
L
S
W
R
D
D
D
R
F
Y
Q
-
Q
---
L
R
S
V
T
A
A
E
V
K
A
A
A
A
R
L
L
T
---------
D
D
T
L
T
V
A
N
L
V
P
L
P
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
79.20
44%
-62
- C1 -
3AMJ
1
?
C:
[7-424]
--------------------------------------
T
F
E
T
T
L
P
N
G
L
K
V
V
V
R
E
D
H
R
A
--
P
T
L
V
H
M
V
W
Y
R
V
G
S
M
D
E
T
T
G
T
T
G
V
A
H
A
L
E
H
M
M
F
K
G
T
K
D
----
V
-
G
-
P
-
G
E
F
S
K
R
V
A
A
M
G
G
R
-----
D
N
A
F
T
T
R
D
Y
T
A
Y
Y
Q
Q
V
P
S
---
S
--
R
L
S
D
V
M
G
L
E
A
D
R
M
A
N
L
---
V
V
D
D
E
L
F
K
K
E
I
Q
V
I
A
E
E
R
R
W
R
T
D
D
K
P
R
S
K
A
Y
E
A
L
M
A
A
S
Y
V
A
H
P
Y
R
V
P
------
V
I
G
W
M
N
D
I
Q
N
------
M
----
T
-------
A
-------
Q
D
V
R
D
W
Y
K
R
W
Y
G
P
N
N
A
T
V
V
V
V
G
D
V
E
H
E
A
V
F
R
L
A
E
Q
T
Y
G
K
L
-
A
R
V
E
A
P
A
R
K
Q
-
Q
-
G
E
--
P
Q
-
Q
-
A
G
--
V
--
R
R
-
V
-
T
V
K
A
P
--
A
E
L
P
Y
L
A
L
A
W
H
V
P
A
I
V
---
D
L
D
K
S
R
D
A
Y
------
A
L
E
I
L
A
A
V
L
D
G
-------
Y
-----------
D
----
G
A
R
M
-----
T
R
Q
L
V
R
--
G
---
N
K
H
A
V
S
A
G
A
G
Y
D
S
--
L
-
S
-
R
G
Q
Q
G
L
F
I
L
E
G
--
V
P
S
--
K
G
V
T
I
A
Q
L
E
T
D
L
R
A
Q
V
R
D
-
I
A
--
A
K
G
V
T
E
A
E
L
S
R
V
K
S
Q
M
V
A
G
K
V
Y
-
E
-----
Q
-
D
S
L
--
M
G
Q
A
T
Q
I
G
G
L
E
V
L
G
---
L
S
W
R
D
D
D
R
F
Y
Q
-
Q
---
L
R
S
V
T
A
A
E
V
K
A
A
A
A
R
L
L
T
---------
D
D
T
L
T
V
A
N
L
V
P
L
P
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
73.07
22%
-58
- C1 -
3HDI
7
?
A:
[2-411]
--------------------------------------
I
N
T
M
T
L
D
N
G
V
R
I
I
T
E
K
M
S
T
V
--
R
S
V
S
I
G
I
W
V
G
T
G
S
R
Y
E
S
A
E
E
N
G
I
S
H
F
L
E
H
M
F
F
K
G
T
N
T
----
R
-
S
-
A
-
Q
E
I
A
E
F
F
D
S
I
G
G
Q
-----
V
N
A
F
T
S
K
E
Y
T
C
Y
Y
A
K
V
L
D
---
D
--
H
A
G
Q
A
I
D
T
L
S
D
M
F
F
H
S
---
T
F
Q
K
E
E
L
E
K
E
R
K
V
V
F
E
E
I
K
M
V
-
D
D
T
P
D
D
I
V
H
D
L
L
S
S
A
T
Y
G
K
H
S
L
G
Y
P
------
I
L
G
T
V
E
T
L
N
S
------
F
----
N
-------
E
-------
G
M
L
R
H
Y
M
D
R
F
Y
T
G
D
Y
V
V
I
S
V
A
G
N
V
H
D
-
E
L
I
D
K
I
K
E
T
F
S
Q
V
-
K
P
T
T
Y
N
Y
-
Q
--
G
-
E
K
--
P
M
-
F
-
L
---
P
--
N
R
-
I
-
V
R
K
K
E
--
T
E
Q
A
H
L
C
L
G
Y
P
G
L
P
I
G
-------
D
K
D
V
Y
------
A
L
V
L
L
N
N
V
L
G
G
-------
S
-----------
M
----
S
S
R
L
-----
F
Q
D
I
R
E
--
K
---
R
G
L
C
Y
S
V
F
S
Y
H
S
S
--
F
-
R
--
D
-
S
G
M
L
T
I
Y
A
--
G
T
G
H
D
---
Q
L
D
D
L
V
Y
S
I
Q
E
T
T
S
A
-
L
A
--
E
K
G
L
T
E
K
E
L
E
N
G
K
E
Q
L
K
G
S
L
M
L
-
S
-----
L
-
E
S
T
--
N
S
R
M
S
R
N
G
K
N
E
L
L
L
---
K
K
H
R
S
L
D
E
M
I
E
-
Q
---
I
N
A
V
Q
K
Q
D
V
S
R
L
A
K
I
L
L
S
---------
A
S
P
-
S
I
S
L
I
N
A
N
G
E
--
L
P
K
A
L
I
H
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
71.62
24%
-60
- C1 -
3HDI
7
?
A:
[6-395]
------------------------------------------
T
L
D
N
G
V
R
I
I
T
E
K
M
S
T
V
--
R
S
V
S
I
G
I
W
V
G
T
G
S
R
Y
E
S
A
E
E
N
G
I
S
H
F
L
E
H
M
F
F
K
G
T
N
T
----
R
-
S
-
A
-
Q
E
I
A
E
F
F
D
S
I
G
G
Q
-----
V
N
A
F
T
S
K
E
Y
T
C
Y
Y
A
K
V
L
D
---
D
--
H
A
G
Q
A
I
D
T
L
S
D
M
F
F
H
S
---
T
F
Q
K
E
E
L
E
K
E
R
K
V
V
F
E
E
I
K
M
-
V
D
D
T
P
D
D
I
V
H
D
L
L
S
S
A
T
Y
G
K
H
S
L
G
Y
P
------
I
L
G
T
V
E
T
L
N
S
------
F
----
N
-------
E
-------
G
M
L
R
H
Y
M
D
R
F
Y
T
G
D
Y
V
V
I
S
V
A
G
N
V
-
H
D
E
L
I
D
K
I
K
E
T
F
S
Q
V
K
P
T
T
Y
N
Y
Q
G
E
K
-
P
-
M
F
--
L
P
----------
N
R
-
I
-
V
R
K
K
E
--
T
E
Q
A
H
L
C
L
G
Y
P
G
L
P
I
G
-------
D
K
D
V
Y
------
A
L
V
L
L
N
N
V
L
G
G
-------
S
-----------
M
----
S
S
R
L
-----
F
Q
D
I
R
E
--
K
---
R
G
L
C
Y
S
V
F
S
Y
H
S
S
--
F
-
R
-
D
S
-
G
M
L
T
I
Y
A
G
--
T
G
H
D
Q
----
L
D
D
L
V
Y
S
I
Q
E
T
T
S
A
-
L
A
--
E
K
G
L
T
E
K
E
L
E
N
G
K
E
Q
L
K
G
S
L
M
L
-
S
-----
L
-
E
S
T
--
N
S
R
M
S
R
N
G
K
N
E
L
L
L
---
K
K
H
R
S
L
D
E
M
I
E
-
Q
---
I
N
A
V
Q
K
Q
D
V
S
R
L
A
K
I
L
L
S
---------
A
S
P
S
I
S
L
I
N
A
N
G
E
L
--
P
K
A
L
I
H
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
68.37
18%
-58
- C1 -
1HR6
1
MPPB_YEAST
B:
[5-433]
------------------------------------
P
G
T
R
T
S
K
L
P
N
G
L
T
I
A
T
E
Y
I
P
N
T
--
S
S
A
T
V
G
I
F
V
D
A
G
S
R
A
E
N
V
K
N
N
G
T
A
H
F
L
E
H
L
A
F
K
G
T
Q
N
----
R
-
P
-
Q
-
Q
G
I
E
L
E
I
E
N
I
G
S
H
-----
L
N
A
Y
T
S
R
E
N
T
V
Y
Y
A
K
S
L
Q
---
E
--
D
I
P
K
A
V
D
I
L
S
D
I
L
T
K
S
---
V
L
D
N
S
A
I
E
R
E
R
D
V
I
I
R
E
S
E
E
V
-
D
K
M
Y
D
E
V
V
F
D
H
L
H
E
I
T
Y
K
D
Q
P
L
G
R
T
------
I
L
G
P
I
K
N
I
K
S
------
I
----
T
-------
R
-------
T
D
L
K
D
Y
I
T
K
N
Y
K
G
D
R
M
V
L
A
G
A
G
A
V
D
H
E
K
L
V
Q
Y
A
Q
K
Y
F
G
H
V
-
P
K
S
E
S
P
V
P
L
G
S
P
-
R
G
P
L
P
V
-
F
-
C
R
--
G
--
E
R
-
F
-
I
K
E
N
T
--
L
P
T
T
H
I
A
I
A
L
E
G
V
S
W
S
-------
A
P
D
Y
F
------
V
A
L
A
T
Q
A
I
V
G
N
W
D
RAIGT
G
TN---------
S
----
P
S
P
L
-----
A
V
A
A
S
Q
--
N
---
G
S
L
A
N
S
Y
M
S
F
S
T
S
--
Y
-
A
--
D
-
S
G
L
W
G
M
Y
I
V
T
D
S
N
E
H
---
N
V
R
L
I
V
N
E
I
L
K
E
W
K
R
-
I
K
--
S
G
K
I
S
D
A
E
V
N
R
A
K
A
Q
L
K
A
A
L
L
L
-
S
-----
L
-
D
G
S
--
T
A
I
V
E
D
I
G
R
Q
V
V
T
T
---
G
K
R
L
S
P
E
E
V
F
E
-
Q
---
V
D
K
I
T
K
D
D
I
I
M
W
A
N
Y
R
L
Q
---------
N
K
P
V
S
M
V
A
L
G
N
T
S
T
--
V
P
N
V
S
Y
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
67.58
20%
-59
- C1 -
3AMJ
-
?
B:
[2-414]
------------------------------------
I
K
I
E
H
W
T
A
P
S
G
A
Q
V
Y
Y
V
E
N
R
T
L
--
P
M
L
D
V
Q
V
D
F
D
A
G
S
A
R
E
P
A
D
Q
V
G
V
A
S
M
T
A
S
L
M
D
A
G
T
G
S
G
KSA
L
-
D
-
E
-
N
A
I
A
D
R
L
A
D
I
G
A
R
-----
L
G
G
G
A
E
A
D
R
A
S
F
S
L
R
V
L
S
---
S
P
A
E
R
N
S
A
L
T
I
L
R
D
I
L
A
H
P
---
T
F
P
A
P
V
L
E
R
E
R
A
R
A
I
A
G
L
R
E
A
-
Q
T
Q
P
G
S
I
L
G
R
R
F
T
E
L
A
Y
G
K
H
P
Y
G
H
V
--------
S
S
V
A
T
L
Q
K
------
I
----
S
-------
R
-------
D
Q
L
V
S
F
H
R
T
H
Y
V
A
R
T
A
V
V
T
L
V
G
D
I
T
R
A
E
A
E
T
I
A
Q
Q
L
T
A
D
L
-
P
A
G
A
T
L
P
-
P
L
---
P
D
--
P
A
-
M
-
P
R
--
A
--
T
V
-
E
-
R
I
A
N
P
--
A
T
Q
A
H
I
A
I
G
M
P
T
L
K
R
G
---
D
----
P
D
F
F
------
P
L
V
V
G
N
Y
A
L
G
G
G------
G
-----------
F
----
E
S
R
L
-----
M
K
E
I
R
D
--
K
---
R
G
L
S
Y
G
A
Y
S
Y
F
S
P
--
Q
-
K
--
S
-
M
G
L
F
Q
I
G
F
--
E
T
R
A
E
---
K
A
D
E
A
V
Q
V
A
N
D
T
L
D
A
-
F
L
--
R
E
G
P
T
D
A
E
L
Q
A
A
K
D
N
L
I
N
G
F
A
L
-
R
-----
L
-
D
S
N
--
A
K
I
L
G
Q
V
A
V
I
G
Y
Y
G
---
L
P
L
D
Y
L
D
H
Y
T
E
-
R
---
V
Q
A
V
T
V
E
Q
V
R
E
A
F
A
R
H
V
K
---------
R
E
N
L
I
T
V
V
V
G
G
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
67.44
18%
-56
- C1 -
1HR6
1
MPPA_YEAST
A:
[4-439]
------------------------------------
D
N
F
K
L
S
S
L
A
N
G
L
K
V
A
T
S
N
T
P
G
---
H
F
S
A
L
G
L
Y
I
D
A
G
S
R
F
E
G
R
N
L
K
G
C
T
H
I
L
D
R
L
A
F
K
S
T
E
H
----
V
-
E
-
G
-
R
A
M
A
E
T
L
E
L
L
G
G
N
-----
Y
Q
C
T
S
S
R
E
N
L
M
Y
Q
A
S
V
F
N
---
Q
--
D
V
G
K
M
L
Q
L
M
S
E
T
V
R
F
P
---
K
I
T
E
Q
E
L
Q
E
Q
K
L
S
A
E
Y
E
I
D
E
V
-
W
M
K
P
E
L
V
L
P
E
L
L
H
T
A
A
Y
S
G
E
T
L
G
S
P
------
L
I
C
P
R
G
L
I
P
S
------
I
----
S
-------
K
-------
Y
Y
L
L
D
Y
R
N
K
F
Y
T
P
E
N
T
V
A
A
F
V
G
-
V
P
H
E
K
A
L
E
L
T
G
K
Y
L
G
D
W
-
Q
S
T
H
P
P
I
T
K
K
---
V
A
--
Q
Y
-
T
-
G
G
E
S
C
I
P
P
A
-
P
-
V
F
G
N
L
--
P
E
L
F
H
I
Q
I
G
F
E
G
L
P
I
D
-------
H
P
D
I
Y
------
A
L
A
T
L
Q
T
L
L
G
G
-------
G
G
S
F
S
A
G
G
P
GKG
M
----
Y
S
R
L
-----
Y
T
H
V
L
N
--
Q
---
Y
Y
F
V
E
N
C
V
A
F
N
H
S
--
Y
-
S
--
D
-
S
G
I
F
G
I
S
L
--
S
C
I
P
Q
---
A
A
P
Q
A
V
E
V
I
A
Q
Q
M
Y
N
T
F
A
NK
D
L
R
L
T
E
D
E
V
S
R
A
K
N
Q
L
K
S
S
L
L
M
-
N
-----
L
-
E
S
K
--
L
V
E
L
E
D
M
G
R
Q
V
L
M
H
---
G
R
K
I
P
V
N
E
M
I
S
-
K
---
I
E
D
L
K
P
D
D
I
S
R
V
A
E
M
I
F
T
GNVNNAGNG
K
G
R
A
T
V
V
M
Q
G
D
R
G
S
--
F
G
D
V
E
N
V
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
66.77
22%
-64
- C1 -
4M1C
2
IDE_HUMAN
A:
[14-982]
----------
N
N
P
A
I
K
R
I
G
N
H
I
T
K
S
-------
P
E
D
K
R
E
Y
R
G
L
E
L
A
N
G
I
K
V
L
L
I
S
D
P
T
T
--
D
K
S
S
A
A
L
D
V
H
I
G
S
L
S
D
P
P
N
I
A
G
L
S
H
F
L
Q
H
M
L
F
L
G
T
K
K
----
Y
-
P
-
K
E
N
E
Y
S
Q
F
L
S
E
H
A
G
S
-----
S
N
A
F
T
S
G
E
H
T
N
Y
Y
F
D
V
S
H
---
E
--
H
L
E
G
A
L
D
R
F
A
Q
F
F
L
S
P
---
L
F
D
E
S
A
K
D
R
E
V
N
A
V
D
S
E
H
E
-
K
N
V
M
N
D
A
W
R
L
F
Q
L
E
K
A
T
G
N
P
K
H
P
F
S
K
F
GTGNKY
T
L
E
T
R
P
N
Q
E
G
------
I
----
V
-------
R
-------
Q
E
L
L
K
F
H
S
A
Y
Y
S
S
N
L
M
A
V
V
V
L
G
R
E
S
L
D
D
L
T
N
L
V
V
K
L
F
S
E
V
-
E
N
K
N
V
P
L
P
E
F
-
P
-
E
H
--
P
F
-
Q
-
E
E
--
H
LK
Q
L
-
Y
-
K
I
V
P
I
--
K
D
I
R
N
L
Y
V
T
F
P
I
P
D
L
------
Q
K
Y
Y
K
S
N
------
P
G
H
Y
L
G
H
L
I
G
H
-------
E
-----------
G
----
P
G
S
L
-----
L
S
E
L
K
S
--
K
GWV
N
T
L
V
G
G
Q
K
E
G
A
--------
R
G
-
F
M
F
F
I
I
N
V
--
D
L
T
E
E
G
L
L
H
V
E
D
I
I
L
H
M
F
Q
Y
I
Q
K
-
L
R
--
A
E
G
P
Q
E
W
V
F
Q
E
L
K
D
L
N
A
V
A
F
R
F
-
K
D----
K
-
E
R
P
--
R
G
Y
T
S
K
I
A
G
I
-------
L
H
Y
Y
P
L
E
E
V
L
T
-
A
EYL
L
E
E
F
R
P
D
L
I
E
M
V
L
D
K
-
L
R
---------
P
E
N
V
R
V
A
I
V
-
S
K
S
F
--
E
G
K
T
D
R
T
E
E
WYG
T
Q
Y
K
Q
E
A
I
P
D
E
V
I
K
K
W
Q
N
ADLNGKFKLPTKNEFIPTNF
E
I
L
P
L
EKEATPYPALIKDTAM
S
K
L
W
F
K
Q
D
DKFFLP
K
A
N
L
N
F
E
F
F
S
PFAYVD
P
L
H
S
N
M
A
Y
L
Y
L
E
L
L
K
D
S
L
N
E
Y
A
Y
A
A
E
L
A
G
L
S
Y
D
L
Q
N
T
IY
G
M
Y
L
S
V
K
G
YNDK
Q
P
I
L
L
K
K
I
I
E
K
M
A
T
F
E
I
D
E
K
R
F
E
I
I
K
E
A
Y
M
R
S
L
N
N
F
R
A
EQ
P
H
Q
H
A
M
Y
Y
L
R
L
L
M
TE
V
A
W
T
K
D
E
L
K
E
A
L
D
D
VT
L
P
R
L
K
A
F
I
P
Q
L
L
S
R
L
H
I
E
A
L
L
H
G
NIT
K
Q
A
A
L
G
I
M
Q
M
V
E
D
T
L
I
E
HAH
T
K
P
L
L
PSQL
V
R
Y
R
E
VQLPDR
G
W
F
V
Y
Q
Q
R
NEVHN
N
S
G
I
E
I
Y
YQTDMQS
T
S
E
N
M
F
L
E
L
F
A
Q
I
I
S
E
P
A
F
N
TLRTKEQLGY
I
V
F
S
G
P
R
R
A
NG
I
Q
G
L
R
F
I
I
Q
S
EKP
P
H
Y
L
E
S
R
V
E
A
F
L
I
T
M
E
K
S
I
E
D
MT
E
E
A
F
Q
K
H
I
Q
A
L
A
I
R
R
L
DKPKK
L
S
A
E
S
A
K
Y
W
G
E
I
I
S
QQYNFD
R
D
N
T
E
V
A
Y
L
K
T
LT
K
E
D
I
I
K
F
Y
K
E
MLAVDAPRRH
K
V
S
V
H
V
L
A
REMDSNPN
L
S
Q
A
P
AL
P
Q
P
E
V
I
QN
M
T
E
F
K
R
G
L
P
L
F
P
L
V
K
P
H-------
25
HHSearch
66.57
20%
-61
* C1 *
1PP9
2
QCR1_BOVIN
A:
[10-433]
----------------------------------
S
V
P
E
T
Q
V
S
Q
L
D
N
G
L
R
V
A
S
E
Q
S
S
-
Q
--
P
T
C
T
V
G
V
W
I
D
A
G
S
R
Y
E
S
E
K
N
N
G
A
G
Y
F
V
E
H
L
A
F
K
G
T
K
N
----
R
-
P
-
G
-
N
A
L
E
K
E
V
E
S
M
G
A
H
-----
L
N
A
Y
S
T
R
E
H
T
A
Y
Y
I
K
A
L
S
---
K
--
D
L
P
K
A
V
E
L
L
A
D
I
V
Q
N
C
---
S
L
E
D
S
Q
I
E
K
E
R
D
V
I
L
Q
E
L
Q
E
N
-
D
T
S
M
R
D
V
V
F
N
Y
L
H
A
T
A
F
Q
G
T
P
L
A
Q
S
------
V
E
G
P
S
E
N
V
R
K
------
L
----
S
-------
R
-------
A
D
L
T
E
Y
L
S
R
H
Y
K
A
P
R
M
V
L
A
A
A
G
G
L
E
H
R
Q
L
L
D
L
A
Q
K
H
F
S
G
L
-
S
G
T
Y
D
E
D
A
V
P
-
T
-
L
S
--
P
C
R
F
-
T
G
--
S
--
Q
I
-
C
-
H
R
E
D
G
--
L
P
L
A
H
V
A
I
A
V
E
G
P
G
W
A
-------
H
P
D
N
V
------
A
L
Q
V
A
N
A
I
I
G
H
-------
Y
D
CTYGGGAH--
L
----
S
S
P
L
-----
A
S
-
I
A
A
--
T
---
N
K
L
C
Q
S
F
Q
T
F
N
I
C
--
Y
-
A
--
D
-
T
G
L
L
G
A
H
F
--
V
C
D
H
M
---
S
I
D
D
M
M
F
V
L
Q
G
Q
W
M
R
-
L
C
---
T
S
A
T
E
S
E
V
L
R
G
K
N
L
L
R
N
A
L
V
S
-
H
-----
L
-
D
G
T
--
T
P
V
C
E
D
I
G
R
S
L
L
T
Y
---
G
R
R
I
P
L
A
E
W
E
S
-
R
---
I
A
E
V
D
A
R
V
V
R
E
V
C
S
K
Y
F
Y
---------
D
Q
C
P
A
V
A
G
F
G
P
I
E
Q
--
L
P
D
Y
N
R
I
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
65.72
20%
-67
- C1 -
3CWW
5
IDE_HUMAN
A:
[18-455]
-----------------
I
K
R
I
G
N
H
I
T
K
S
P
E
D
----
K
R
E
Y
R
G
L
E
L
A
N
G
I
K
V
L
L
I
S
D
P
T
T
--
D
K
S
S
A
A
L
D
V
H
I
G
S
L
S
D
P
P
N
I
A
G
L
S
H
F
L
Q
H
M
L
F
L
G
T
K
K
----
Y
-
P
K
E
-
N
E
Y
S
Q
F
L
S
E
H
A
G
S
-----
S
N
A
F
T
S
G
E
H
T
N
Y
Y
F
D
V
S
H
---
E
--
H
L
E
G
A
L
D
R
F
A
Q
F
F
L
S
P
---
L
F
D
E
S
A
K
D
R
E
V
N
A
V
D
S
E
H
E
K
N
-
V
M
N
D
A
W
R
L
F
Q
L
E
K
A
T
G
N
P
K
H
P
F
S
K
F
------
G
T
G
N
K
Y
T
L
E
T
R
P
N
Q
E
G
I
D---
V
-------
R
-------
Q
E
L
L
K
F
H
S
A
Y
Y
S
S
N
L
M
A
V
V
V
L
G
R
E
S
L
D
D
L
T
N
L
V
V
K
L
F
S
E
V
-
E
N
K
N
V
P
L
P
E
F
-
P
-
E
H
--
P
F
-
Q
-
E
E
H-
L
--
K
Q
-
L
Y
K
I
V
P
I
--
K
D
I
R
N
L
Y
V
T
F
P
I
P
D
L
Q
---
K
---
Y
Y
K
S
N
------
P
G
H
Y
L
G
H
L
I
G
H
-------
E
-----------
G
----
P
G
S
L
-----
L
S
E
L
K
S
--
K
----
G
W
V
N
T
L
V
G
G
Q
K
A
--
G
A
R
--
G
-
F
M
F
F
I
I
N
V
--
D
L
T
E
E
G
L
L
H
V
E
D
I
I
L
H
M
F
Q
Y
I
Q
K
-
L
R
--
A
E
G
P
Q
E
W
V
F
Q
E
L
K
D
L
N
A
V
A
F
R
F
K
D
-----
K
-
E
R
P
--
R
G
Y
T
S
K
I
A
G
I
L
H
Y
----
Y
P
L
E
E
V
L
T
A
E
Y
-
L
---
L
E
E
F
R
P
D
L
I
E
M
V
L
D
K
-
L
R
---------
P
E
N
V
R
V
A
I
V
S
K
S
F
E
--
G
K
T
D
R
T
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
64.43
19%
-57
- C1 -
1BGY
1
QCR1_BOVIN
A:
[1-446]
-------------------------
T
A
T
Y
A
Q
A
L
Q
S
V
P
E
T
Q
V
S
Q
L
D
N
G
L
R
V
A
S
-
E
Q
S
S
Q
--
P
T
C
T
V
G
V
W
I
D
A
G
S
R
Y
E
S
E
K
N
N
G
A
G
Y
F
V
E
H
L
A
F
K
G
T
K
N
----
R
-
P
-
G
-
N
A
L
E
K
E
V
E
S
M
G
A
H
-----
L
N
A
Y
S
T
R
E
H
T
A
Y
Y
I
K
A
L
S
---
K
--
D
L
P
K
A
V
E
L
L
A
D
I
V
Q
N
C
---
S
L
E
D
S
Q
I
E
K
E
R
D
V
I
L
Q
E
L
Q
E
N
-
D
T
S
M
R
D
V
V
F
N
Y
L
H
A
T
A
F
Q
G
T
P
L
A
Q
S
------
V
E
G
P
S
E
N
V
R
K
------
L
----
S
-------
R
-------
A
D
L
T
E
Y
L
S
R
H
Y
K
A
P
R
M
V
L
A
A
A
G
G
L
E
H
R
Q
L
L
D
L
A
Q
K
H
F
S
G
L
-
S
G
T
Y
D
E
D
A
V
P
-
T
-
L
S
--
P
C
-
R
F
T
G
--
S
--
Q
I
-
C
-
H
R
E
D
G
--
L
P
L
A
H
V
A
I
A
V
E
G
P
G
W
A
---
H
----
P
D
N
V
------
A
L
Q
V
A
N
A
I
I
G
H
-------
Y
D
CTYGGGAH--
L
----
S
S
P
L
-----
A
S
I
A
A
T
--
N
----
K
L
C
Q
S
F
Q
T
F
N
I
C
--
Y
-
A
-
D
T
--
G
L
L
G
A
H
F
--
V
C
D
---
H
M
S
I
D
D
M
M
F
V
L
Q
G
Q
W
M
R
-
L
C
--
T
-
S
A
T
E
S
E
V
L
R
G
K
N
L
L
R
N
A
L
V
S
-
H
-----
L
-
D
G
T
--
T
P
V
C
E
D
I
G
R
S
L
L
T
Y
---
G
R
R
I
P
L
A
E
W
E
S
-
R
---
I
A
E
V
D
A
R
V
V
R
E
V
C
S
K
Y
F
Y
---------
D
Q
C
P
A
V
A
G
F
G
P
I
E
Q
LP
D
Y
N
R
I
R
S
G
M
F
WLRF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
64.30
19%
-55
- C1 -
2G47
2
IDE_HUMAN
A:
[16-987]
------------
P
A
I
K
R
I
G
N
-------
H
I
T
K
S
P
E
D
K
R
E
Y
R
G
L
E
L
A
N
G
I
K
V
L
L
I
S
D
P
T
T
--
D
K
S
S
A
A
L
D
V
H
I
G
S
L
S
D
P
P
N
I
A
G
L
S
H
F
C
Q
H
M
L
F
L
G
T
K
K
----
Y
P
K
-
E
-
N
E
Y
S
Q
F
L
S
E
H
A
G
S
-----
S
N
A
F
T
S
G
E
H
T
N
Y
Y
F
D
V
S
H
---
E
--
H
L
E
G
A
L
D
R
F
A
Q
F
F
L
C
P
---
L
F
D
E
S
C
K
D
R
E
V
N
A
V
D
S
E
H
E
K
N
V
M
N
-
D
A
W
R
L
F
Q
L
E
K
A
T
G
N
P
K
H
P
F
S
K
F
------
G
T
G
N
K
Y
T
L
E
T
------
R
----
P
-------
N
Q
E
GID
V
R
Q
E
L
L
K
F
H
S
A
Y
Y
S
S
N
L
M
A
V
C
V
L
G
R
E
S
L
D
D
L
T
N
L
V
V
K
L
F
S
E
V
-
E
N
K
N
V
P
L
P
E
F
-
P
-
E
H
--
P
F
-
Q
-
E
E
--
H
--
L
K
-
Q
-
L
Y
K
I
V
P
I
K
D
I
R
N
L
Y
V
T
F
P
I
P
D
L
------
Q
K
Y
Y
K
S
N
------
P
G
H
Y
L
G
H
L
I
G
H
-------
E
-----------
G
----
P
G
S
L
-----
L
S
E
L
K
S
------
K
G
W
V
N
T
L
V
G
G
Q
K
E
--
G
-
A
-
R
G
-
F
M
F
F
I
I
N
V
--
D
L
T
E
E
G
L
L
H
V
E
D
I
I
L
H
M
F
Q
Y
I
Q
K
-
L
R
--
A
E
G
P
Q
E
W
V
F
Q
E
C
K
D
L
N
A
V
A
F
R
F
-
K
-----
D
-
K
E
R
--
P
R
G
Y
T
S
K
I
A
G
I
L
H
Y
---
Y
P
L
E
E
V
L
T
A
E
Y
-
L
---
L
E
E
F
R
P
D
L
I
E
M
V
L
D
-
K
L
R
---------
P
E
N
V
R
V
A
I
V
S
K
S
F
E
--
G
K
T
D
R
T
E
E
WYG
T
Q
Y
K
Q
E
A
IP
D
E
V
I
K
K
W
Q
N
ADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAM
S
K
L
W
F
K
Q
DDKFFLP
K
A
C
L
N
F
E
F
F
S
PFAYVD
P
L
H
C
N
M
A
Y
L
Y
L
E
L
L
K
D
S
L
N
E
Y
A
Y
A
A
E
L
A
G
L
S
Y
D
L
Q
N
T
IY
G
M
Y
L
S
V
K
G
YNDK
Q
P
I
L
L
K
K
I
I
E
K
M
A
T
F
E
I
D
E
K
R
F
E
I
I
K
E
A
Y
M
R
S
L
N
N
FRAEQ
P
H
Q
H
A
M
Y
Y
L
R
L
L
M
TE
V
A
W
T
K
D
E
L
K
E
A
L
D
D
VT
L
P
R
L
K
A
F
I
P
Q
L
L
S
R
L
H
I
E
A
L
L
H
G
NIT
K
Q
A
A
L
G
I
M
Q
M
V
E
D
T
L
I
E
H
AH
T
K
P
L
L
PSQL
V
R
Y
R
E
VQLPDR
G
W
F
V
Y
Q
Q
R
N
EVHN
N
C
G
I
E
I
Y
YQTDMQS
T
S
E
N
M
F
L
E
L
F
C
Q
I
I
S
E
P
C
F
N
T
LRTKEQLGY
I
V
F
S
G
P
R
R
A
NGI
Q
G
L
R
F
I
I
Q
S
EKP
P
H
Y
L
E
S
R
V
E
A
F
L
I
T
M
E
K
S
I
E
D
MT
E
E
A
F
Q
K
H
I
Q
A
L
A
I
R
R
L
DKPKK
L
S
A
E
C
A
K
Y
W
G
E
I
I
S
QQYNFD
R
D
N
T
E
V
A
Y
L
K
T
LT
K
E
D
I
I
K
F
Y
K
E
MLAVDAPR
R
H
K
V
S
V
H
V
L
A
REMDSCPVVGNLSQAPAL
P
Q
P
E
V
I
QN
M
T
E
F
K
R
G
L
P
L
F
P
L
VKPH
I
N
F
M
A
32
HHSearch
63.98
18%
-65
- C1 -
1Q2L
3
PTRA_ECOLI
A:
[18-439]
-----------------------------------
N
R
Q
Y
Q
A
I
R
L
D
N
G
M
V
V
L
L
V
S
D
P
Q
A
--
V
K
S
L
S
A
L
V
V
P
V
G
S
L
E
D
P
E
A
Y
Q
G
L
A
H
Y
L
E
H
M
S
L
M
G
S
K
K
----
Y
-
P
Q
A
-
D
S
L
A
E
Y
L
K
M
H
G
G
S
-----
H
N
A
S
T
A
P
Y
R
T
A
F
Y
L
E
V
E
N
---
D
--
A
L
P
G
A
V
D
R
L
A
D
A
I
A
E
P
---
L
L
D
K
K
Y
A
E
R
E
R
N
A
V
N
A
E
L
T
M
A
-
R
T
R
D
G
M
R
M
A
Q
V
S
A
E
T
I
N
P
A
H
P
G
S
K
F
------
S
G
G
N
L
E
T
L
S
D
------
K
PGNP
V
-------
Q
-------
Q
A
L
K
D
F
H
E
K
Y
Y
S
A
N
L
M
K
A
V
I
Y
S
N
K
P
L
P
E
L
A
K
M
A
A
D
T
F
G
R
V
-
P
N
K
E
S
K
K
P
E
I
T
V
-
P
V
--
V
T
-
D
-
A
Q
--
K
--
G
I
I
I
-
H
Y
V
P
A
--
L
P
R
K
V
L
R
V
E
F
R
I
D
N
N
S
---
A
---
K
F
R
S
K
------
T
D
E
L
I
T
Y
L
I
G
N
-------
R
-----------
S
----
P
G
T
L
-----
S
D
W
L
Q
K
------
Q
G
L
V
E
G
I
S
A
N
S
D
P
IV
N
-
G
--
N
-
S
G
V
L
A
I
S
A
--
S
L
T
D
K
G
L
A
N
R
D
Q
V
V
A
A
I
F
S
Y
L
N
L
-
L
R
--
E
K
G
I
D
K
Q
Y
F
D
E
L
A
N
V
L
D
I
D
F
R
Y
-
P
-----
S
I
T
R
D
--
M
D
Y
V
E
W
L
A
D
T
M
I
R
----
V
P
V
E
H
T
L
D
A
V
N
-
I
---
A
D
R
Y
D
A
K
A
V
K
E
R
L
A
M
M
-
T
---------
P
Q
N
A
R
I
W
Y
I
S
P
K
E
P
--
H
N
K
T
A
Y
F
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Fugue
62.54
19%
-56
- C1 -
2JBU
2
IDE_HUMAN
A:
[15-987]
-----------
N
P
A
I
K
R
I
G
N
-------
H
I
T
K
S
P
E
D
K
R
E
Y
R
G
L
E
L
A
N
G
I
K
V
L
L
I
S
D
P
T
T
--
D
K
S
S
A
A
L
D
V
H
I
G
S
L
S
D
P
P
N
I
A
G
L
S
H
F
C
Q
H
M
L
F
L
G
T
K
K
----
Y
P
K
-
E
-
N
E
Y
S
Q
F
L
S
E
H
A
G
S
-----
S
N
A
F
T
S
G
E
H
T
N
Y
Y
F
D
V
S
H
---
E
--
H
L
E
G
A
L
D
R
F
A
Q
F
F
L
C
P
---
L
F
D
E
S
C
K
D
R
E
V
N
A
V
D
S
E
H
E
K
N
V
M
N
-
D
A
W
R
L
F
Q
L
E
K
A
T
G
N
P
K
H
P
F
S
K
F
------
G
T
G
N
K
Y
T
L
E
T
------
R
----
P
N
Q
E
GID
V
R
-------
Q
E
L
L
K
F
H
S
A
Y
Y
S
S
N
L
M
A
V
C
V
L
G
R
E
S
L
D
D
L
T
N
L
V
V
K
L
F
S
E
V
-
E
N
K
N
V
P
L
P
E
F
-
P
-
E
H
--
P
F
-
Q
-
E
E
--
H
--
L
K
-
Q
-
L
Y
K
I
V
P
I
K
D
I
R
N
L
Y
V
T
F
P
I
P
D
L
------
Q
K
Y
Y
K
S
N
------
P
G
H
Y
L
G
H
L
I
G
H
-------
E
-----------
G
----
P
G
S
L
-----
L
S
E
L
K
S
------
K
G
W
V
N
T
L
V
G
G
Q
K
E
--
G
-
A
-
R
G
-
F
M
F
F
I
I
N
V
--
D
L
T
E
E
G
L
L
H
V
E
D
I
I
L
H
M
F
Q
Y
I
Q
K
-
L
R
--
A
E
G
P
Q
E
W
V
F
Q
E
C
K
D
L
N
A
V
A
F
R
F
-
K
-----
D
-
K
E
R
--
P
R
G
Y
T
S
K
I
A
G
I
L
H
Y
---
Y
P
L
E
E
V
L
T
A
E
Y
-
L
---
L
E
E
F
R
P
D
L
I
E
M
V
L
D
K
-
L
R
---------
P
E
N
V
R
V
A
I
V
S
K
S
F
E
--
G
K
T
D
R
T
E
E
WYG
T
Q
Y
K
Q
E
A
IP
D
E
V
I
K
K
W
Q
N
ADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAM
S
K
L
W
F
K
Q
DDKFFLP
K
A
C
L
N
F
E
F
F
S
PFAYVD
P
L
H
C
N
M
A
Y
L
Y
L
E
L
L
K
D
S
L
N
EYA
Y
A
A
E
L
A
G
L
S
Y
D
L
Q
N
T
IY
G
M
Y
L
S
V
K
G
YNDK
Q
P
I
L
L
K
K
I
I
E
K
M
A
T
F
E
I
D
E
K
R
F
E
I
I
K
E
A
Y
M
R
S
L
N
N
FRAEQ
P
H
Q
H
A
M
Y
Y
L
R
L
L
M
TE
V
A
W
T
K
D
E
L
K
E
A
LDDVT
L
P
R
L
K
A
F
I
P
Q
L
L
S
R
L
H
I
E
A
L
L
H
G
NIT
K
Q
A
A
L
G
I
M
Q
M
V
E
D
T
L
I
E
H
AH
T
K
P
L
L
PSQL
V
R
Y
R
E
VQLPDR
G
W
F
V
Y
Q
Q
R
N
EVHN
N
C
G
I
E
I
Y
YQTDMQS
T
S
E
N
M
F
L
E
L
F
C
Q
I
I
S
E
P
C
F
N
T
LRTKEQLGY
I
V
F
S
G
P
R
R
A
NG
I
Q
G
L
R
F
I
I
Q
S
EKP
P
H
Y
L
E
S
R
V
E
A
F
L
I
T
M
E
K
S
I
E
D
MT
E
E
A
F
Q
K
H
I
Q
A
L
A
I
R
R
L
DKPKK
L
S
A
E
C
A
K
Y
W
G
E
I
I
S
QQYNFD
R
D
N
T
E
V
A
Y
L
K
T
LT
K
E
D
I
I
K
F
Y
K
E
MLAVDAPR
R
H
K
V
S
V
H
V
L
A
REMDSCPVLSQAPALPQPEVIQN
M
T
E
F
K
R
G
L
P
L
F
P
L
V
KPHINFMA---
47
Fugue
61.13
16%
-53
- C1 -
1Q2L
6
PTRA_ECOLI
A:
[1-937]
----------
E
T
G
W
Q
P
I
Q
E
--------
T
I
R
K
S
D
K
D
N
R
Q
Y
Q
A
I
R
L
D
N
G
M
V
V
L
L
V
S
D
P
Q
A
--
V
K
S
L
S
A
L
V
V
P
V
G
S
L
E
D
P
E
A
Y
Q
G
L
A
H
Y
L
E
H
M
S
L
M
G
S
K
K
----
Y
P
Q
-
A
-
D
S
L
A
E
Y
L
K
M
H
G
G
S
-----
H
N
A
S
T
A
P
Y
R
T
A
F
Y
L
E
V
E
N
---
D
--
A
L
P
G
A
V
D
R
L
A
D
A
I
A
E
P
---
L
L
D
K
K
Y
A
E
R
E
R
N
A
V
N
A
E
L
T
M
A
-
R
T
R
D
G
M
R
M
A
Q
V
S
A
E
T
I
N
P
A
H
P
G
S
K
F
------
S
G
G
N
L
E
T
L
S
D
------
K
PGNP
V
-------
Q
-------
Q
A
L
K
D
F
H
E
K
Y
Y
S
A
N
L
M
K
A
V
I
Y
S
N
K
P
L
P
E
L
A
K
M
A
A
D
T
F
G
R
V
-
P
N
K
E
S
K
K
P
E
I
-
T
-
V
P
--
V
V
-
T
-
D
A
--
Q
--
K
G
-
I
-
I
I
H
Y
V
P
A
L
P
R
K
V
L
R
V
E
F
R
I
D
N
N
------
S
A
K
F
R
S
K
------
T
D
E
L
I
T
Y
L
I
G
N
-------
R
-----------
S
----
P
G
T
L
-----
S
D
W
L
Q
K
--
Q
---
G
L
V
E
G
I
S
A
N
S
D
P
I
--
V
-
N
-
G
N
-
S
G
V
L
A
I
S
A
--
S
L
T
D
K
G
L
A
N
R
D
Q
V
V
A
A
I
F
S
Y
L
N
L
-
L
R
--
E
K
G
I
D
K
Q
Y
F
D
E
L
A
N
V
L
D
I
D
F
R
Y
-
P
-----
S
-
I
T
R
--
D
M
D
Y
V
E
W
L
A
D
T
M
I
R
---
V
P
V
E
H
T
L
D
A
V
N
-
I
---
A
D
R
Y
D
A
K
A
V
K
E
R
L
A
M
-
M
T
---------
P
Q
N
A
R
I
W
Y
I
S
P
K
E
P
--
H
N
K
T
A
Y
F
V
D
A
P
Y
Q
V
D
KIS
A
Q
T
F
A
D
W
Q
K
K
A
A
D
I
A
L
S
L
P
ELNPYIPDDF
S
L
I
K
S
EKKYDHPELIVDESN
L
R
V
V
Y
A
P
S
RYFASEP
K
A
D
V
S
L
I
LRNPKAMDS
A
R
N
Q
V
M
F
A
L
N
D
Y
L
A
G
L
A
L
D
Q
L
S
N
Q
A
S
V
G
G
I
S
F
S
T
N
A
N
N
G
L
M
V
N
A
N
GYTQR
L
P
Q
L
F
Q
A
L
L
E
G
Y
F
S
Y
T
A
TE
D
Q
L
E
Q
A
K
S
W
Y
N
Q
M
M
D
S
A
E
KGK
A
F
E
Q
A
I
MPAQMLSQV
P
Y
F
S
R
D
E
R
R
K
I
LPSIT
L
K
E
V
L
A
Y
R
D
A
L
K
SG
A
R
P
E
F
M
V
I
G
NMT
E
A
Q
A
T
T
L
A
R
D
V
Q
K
Q
L
GADGS
E
W
C
R
N
K
D
V
V
VD
K
K
Q
S
V
I
F
E
K
A
G
NST
D
S
A
L
A
A
V
F
V
P
T
GYD
E
Y
T
S
S
A
Y
S
S
L
L
G
Q
I
V
Q
PWFYNQLRTEEQLGYA
V
F
A
F
P
M
S
V
GR
Q
W
G
M
G
F
L
L
Q
S
NDKQ
P
S
F
L
W
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Y
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A
F
F
P
T
A
E
A
K
L
R
A
MK
P
D
E
F
A
Q
I
Q
Q
A
V
I
T
Q
M
L
QAPQT
L
G
E
E
A
S
K
L
S
K
D
F
D
R
GNMRFD
S
R
D
K
I
V
A
Q
I
K
L
LT
P
Q
K
L
A
D
F
F
H
Q
A
VVEPQ
G
M
A
I
L
S
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SGSQNGKA
E
Y
V
H
P
E
G
W
K
V
W
EN
V
S
A
L
Q
Q
T
M
P
L
M
S
EK--------------------------
33
HHSearch
57.68
17%
-58
- C1 -
3GO9
6
?
A:
[20-453]
--------------------------------
L
Q
P
D
P
A
W
Q
Q
G
K
L
D
N
G
F
S
W
Q
L
L
A
T
P
Q
R
PS
D
R
I
E
L
R
L
I
V
N
T
G
S
L
S
E
N
T
Q
E
V
G
F
A
H
L
L
P
R
L
A
L
M
S
S
A
S
----
F
-
T
-
P
-
A
Q
L
Q
S
L
W
-
Q
Q
G
I
D
NERPL
P
P
A
I
T
S
Y
D
F
T
L
Y
S
L
S
L
P
N
NR
P
D
--
L
L
K
D
A
L
A
W
L
S
D
T
A
G
N
L
---
A
V
S
E
Q
T
V
N
A
A
L
N
T
A
T
D
P
I
A
T
F
-
P
Q
N
I
Q
E
P
W
W
R
---
Y
R
L
K
G
S
S
L
I
G
H
D
-------
P
-
G
Q
P
V
T
Q
P
------
V
----
D
-------
V
-------
E
K
L
K
Q
F
Y
Q
Q
W
Y
T
P
D
A
M
T
L
Y
V
V
G
N
V
D
S
R
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I
A
A
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I
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K
A
F
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E
L
-
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G
K
R
T
A
P
A
A
V
-
A
T
L
A
--
P
L
-
P
-
P
E
-----
P
V
-
S
-
L
M
N
E
Q
--
A
A
Q
D
T
L
S
L
M
W
D
T
P
W
H
P
---
I
----
Q
D
S
M
A
L
S
R
Y
W
R
S
D
L
A
R
E
A
L
F
W
--------------------------
H
I
-----
K
Q
V
L
E
K
N
N
Q
---
K
N
L
K
L
G
F
D
C
R
V
Q
Y
-------
Q
-
R
A
Q
C
A
I
H
L
--
N
T
P
V
E
---
N
L
T
A
N
M
T
F
V
A
R
E
L
A
A
-
L
R
--
A
N
G
L
S
Q
A
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D
A
L
M
T
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K
N
D
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L
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K
-
L
F
A
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Y
A
R
-
T
D
T
--
D
I
L
M
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Q
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L
R
S
Q
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S
G
V
V
D
I
A
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E
Q
Y
Q
K
L
R
Q
A
F
---
L
S
G
L
T
L
A
E
L
N
R
E
L
K
Q
Q
L
S
---------
Q
D
T
-
T
L
V
L
M
Q
P
K
G
E
--
P
E
V
N
V
K
A
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
57.66
14%
-53
- C1 -
3CX5
1
CYC1_YEAST (first)
A:
[2-413]
---------------------------------------
E
V
T
Q
L
S
N
G
I
V
V
A
T
E
H
N
P
S
A
--
H
T
A
S
V
G
V
V
F
G
S
G
A
A
N
E
N
P
Y
N
N
G
V
S
N
L
W
K
N
I
F
L
S
K
E
N
--------------
S
A
V
A
A
K
E
G
L
A
-----
L
S
S
N
I
S
R
D
F
Q
S
Y
I
V
S
S
L
P
---
G
--
S
T
D
K
S
L
D
F
L
N
Q
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F
I
Q
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KAN
L
L
S
S
S
N
F
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A
T
K
K
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L
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P
N
R
V
L
E
H
L
H
S
T
A
F
Q
N
T
P
L
S
L
P
------
T
R
G
T
L
E
S
L
E
N
------
L
----
V
-------
V
-------
A
D
L
E
S
F
A
N
N
H
F
L
N
S
N
A
V
V
V
G
T
G
N
I
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H
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L
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I
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S
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N
L
S
L
-
Q
T
G
T
K
P
V
L
K
----
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K
--
A
A
-
F
-
L
G
--
S
--
E
V
-
R
-
L
R
D
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--
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A
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-------
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P
N
Y
F
------
V
A
K
L
A
A
Q
I
F
G
S
-------
Y
-----------
N
AFE
P
A
S
R
L
QGI
K
L
L
D
N
I
Q
E
--
Y
----
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L
C
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N
F
N
H
F
S
L
S
--
Y
-
K
--
D
-
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G
L
W
G
F
S
T
--
A
T
R
N
V
T
--
M
I
D
D
L
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H
F
T
L
K
Q
W
N
R
-
L
T
---
I
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V
T
D
T
E
V
E
R
A
K
S
L
L
K
L
Q
L
G
Q
-
L
-----
Y
-
E
S
G
N
P
V
N
D
A
N
L
L
G
A
E
V
L
I
K
---
G
S
K
L
S
L
G
E
A
F
K
-
K
---
I
D
A
I
T
V
K
D
V
K
A
W
A
G
K
R
L
W
---------
D
Q
D
--
I
A
I
A
G
T
G
Q
I
--
E
G
L
L
D
Y
M
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------