@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0402: (2016-01-03 )
MPTDAKRPLQLNDQGQLRHFISLDGLPRELLTEILDTADSFLEVGARAVKKVPLLRGKTVCNVFFENSTRTRTTFELAAQRLSADVISLNVSTSSTSKGETLTDTLRNLEAMAADMFVVRHSDSGAAHFIAEHVSPNVAVINGGDGRHAHPTQGMLDMLTIRRHKGNFEQLSVAIVGDILHSRVARSNMLALKTLGCPDIRVIAPRTLLPIGLEEQYGVRVFTNADEGLKDVDVVIMLRLQRERMQGGLLPSEGEFFKLYGLTEKRLKLAKPDAIVMHPGPINRGVEIESAVADGAQSVILNQVTYGIAIRMAVLSMAMSGQNTQRQLEQEDAE
Atome Classification :
(57 SA)
.........10........20........30........40........50........60........70........80........-90-.--.......100.......110.......120.......130..-..-...140.......150.......160.......170.......180.......190.......200......-.210-.-..-----....---.--.--220--.......230.......240.......250.......---260.......---270.......280.......290.......300.......310.......320.......330..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPTDAKRPLQLN
D
Q
G
Q
L
R
H
F
I
SLDGL
P
R
E
L
L
T
E
I
L
D
T
A
D
S
F
L
E
V
G
A
R
A
V
K
KVPLLRG
K
T
V
C
N
V
F
FENSTRT
R
T
T
F
E
L
A
A
Q
R
LSA
D
V
I
S
L
-
N
V-S--TSSTSKG
E
T
L
T
D
T
L
R
N
L
E
A
M
A
A
D
M
F
V
V
R
HSDS
G
A
A
H
F
I
A
E
HV-SP-
N
V
A
V
I
NGGDGRHAHPTQ
G
M
L
D
M
L
T
I
R
RHKG
N
F
E
Q
L
S
V
A
I
V
G
D
I
L
H
S
R
V
A
RSN
M
L
A
L
K
TLGCPD
I
R
V
IAPR
T
L
-LP---I-GL-----EEQY---
G
--
V
--
R
V
F
--TNADEGL
K
D
V
D
V
V
I
M
L
R
L
Q
R
E
R
MQGGLLPSEG
E
F
F
K
L
---YGL
T
E
K
R
LKL---AKP
D
A
I
V
MHPGPINRG
V
E
I
E
S
A
V
AD
G
A
Q
S
V
I
L
N
Q
V
T
Y
G
I
A
I
R
M
A
V
L
S
M
A
MSGQ
N
T
Q
R
Q
L
E
Q
EDAE
3
PsiBlast_PDB
95.83
39%
-110
- C6 -
3R7F
7
PYRB_BACSU
A:
[1-289]
----------------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
-----
K
S
G
K
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
--
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
---
E
Y
Y
E
E
L
V
-
S
Q
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
G
A
---
R
V
L
F
S
G
P
S
-
E
W
---
Q
-
D
E
-----
E
N
T
F
---
G
------
T
Y
--
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
---
Y
G
L
T
V
E
R
A
E
R
---
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
-------------
102
HHSearch
95.81
38%
-119
- C6 -
3R7F
7
PYRB_BACSU
A:
[1-291]
----------------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
-----
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
--
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
Q
V
----
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
G
A
-
R
V
L
F
S
G
P
S
E
W
-
Q
D
---
E
-
E
N
-----
T
---------
F
--
G
T
Y
--
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
--
V
S
Q
E
G
Y
L
N
K
---
Y
G
L
T
V
E
R
A
E
R
---
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
-------------
6
PsiBlast_PDB
95.60
39%
-121
- C6 -
3D6N
1
PYRB_AQUAE
B:
[1-291]
----------------
M
R
S
L
I
S
S
L
D
L
T
R
E
E
V
E
E
I
L
K
Y
A
K
E
F
K
E
G
K
E
E
T
I
K
A
S
A
V
L
-------
F
F
S
E
P
S
T
R
T
R
L
S
F
E
K
A
A
R
E
L
G
I
E
T
Y
L
V
-
S
G
-
S
--
E
S
S
T
V
K
G
E
S
F
F
D
T
L
K
T
F
E
G
L
G
F
D
Y
V
V
F
R
V
P
F
V
F
F
P
Y
--
K
E
I
V
K
S
L
-
N
L
R
L
V
N
A
G
D
G
T
H
Q
H
P
S
Q
G
L
I
D
F
F
T
I
K
E
H
F
G
E
V
K
D
L
R
V
L
Y
V
G
D
I
K
H
S
R
V
F
R
S
G
A
P
L
L
N
M
F
G
A
K
-
I
G
V
C
G
P
K
T
L
-
I
P
---
R
-
D
V
------
E
V
F
---
K
--
V
--
D
V
F
--
D
D
V
D
K
G
I
D
W
A
D
V
V
I
W
L
R
L
Q
K
E
R
Q
K
E
N
Y
I
P
S
E
S
S
Y
F
K
Q
---
F
G
L
T
K
E
R
F
E
K
---
V
K
---
L
Y
M
H
P
G
P
V
N
R
N
V
D
I
D
H
E
L
V
Y
T
E
K
S
L
I
Q
E
Q
V
K
N
G
I
P
V
R
K
A
I
Y
K
F
L
W
T
--------------
5
PsiBlast_PDB
95.34
39%
-121
- C6 -
4BJH
14
PYRB_AQUAE
B:
[32-322]
----------------
M
R
S
L
I
S
S
L
D
L
T
R
E
E
V
E
E
I
L
K
Y
A
K
E
F
K
E
G
K
E
E
T
I
K
A
S
A
V
L
-------
F
F
S
E
P
S
T
R
T
R
L
S
F
E
K
A
A
R
E
L
G
I
E
T
Y
L
V
-
S
G
-
S
--
E
S
S
T
V
K
G
E
S
F
F
D
T
L
K
T
F
E
G
L
G
F
D
Y
V
V
F
R
V
P
F
V
F
F
P
Y
--
K
E
I
V
K
S
L
-
N
L
R
L
V
N
A
G
D
G
T
H
Q
H
P
S
Q
G
L
I
D
F
F
T
I
K
E
H
F
G
E
V
K
D
L
R
V
L
Y
V
G
D
I
K
H
S
R
V
F
R
S
G
A
P
L
L
N
M
F
G
A
K
-
I
G
V
C
G
P
K
T
L
-
I
P
---
R
-
D
V
------
E
V
F
---
K
--
V
--
D
V
F
--
D
D
V
D
K
G
I
D
W
A
D
V
V
I
W
L
R
L
Q
K
E
R
Q
K
E
N
Y
I
P
S
E
S
S
Y
F
K
Q
---
F
G
L
T
K
E
R
F
E
K
---
V
K
---
L
Y
M
H
P
G
P
V
N
R
N
V
D
I
D
H
E
L
V
Y
T
E
K
S
L
I
Q
E
Q
V
K
N
G
I
P
V
R
K
A
I
Y
K
F
L
W
T
--------------
23
PsiBlast_CBE
94.09
39%
-106
- C6 -
3R7L
3
PYRB_BACSU
D:
[1-289]
----------------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
-----
K
S
G
K
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
--
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
---
E
Y
Y
E
E
L
V
-
S
Q
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
G
A
---
R
V
L
F
S
G
P
S
-
E
W
---
Q
-
D
E
-----
E
N
T
F
---
G
------
T
Y
--
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
---
Y
G
L
T
V
E
R
A
E
R
---
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
--------------
27
PsiBlast_CBE
94.00
39%
-110
- C6 -
3R7F
8
PYRB_BACSU
B:
[1-289]
----------------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
-----
K
S
G
K
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
--
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
---
E
Y
Y
E
E
L
V
-
S
Q
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
G
A
---
R
V
L
F
S
G
P
S
-
E
W
---
Q
-
D
E
-----
E
N
T
F
---
G
------
T
Y
--
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
---
Y
G
L
T
V
E
R
A
E
R
---
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
-------------
21
PsiBlast_CBE
93.99
39%
-106
- C6 -
3R7L
3
PYRB_BACSU
F:
[1-289]
----------------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
-----
K
S
G
K
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
--
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
---
E
Y
Y
E
E
L
V
-
S
Q
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
G
A
---
R
V
L
F
S
G
P
S
-
E
W
---
Q
-
D
E
-----
E
N
T
F
---
G
------
T
Y
--
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
---
Y
G
L
T
V
E
R
A
E
R
---
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
--------------
26
PsiBlast_CBE
93.92
39%
-106
- C6 -
3R7F
7
PYRB_BACSU
C:
[1-289]
----------------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
-----
K
S
G
K
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
--
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
---
E
Y
Y
E
E
L
V
-
S
Q
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
G
A
---
R
V
L
F
S
G
P
S
-
E
W
---
Q
-
D
E
-----
E
N
T
F
---
G
------
T
Y
--
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
---
Y
G
L
T
V
E
R
A
E
R
---
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
-------------
29
PsiBlast_CBE
93.49
39%
-110
- C6 -
3R7D
2
PYRB_BACSU
B:
[1-289]
----------------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
-----
K
S
G
K
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
--
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
---
E
Y
Y
E
E
L
V
-
S
Q
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
G
A
---
R
V
L
F
S
G
P
S
-
E
W
---
Q
-
D
E
-----
E
N
T
F
---
G
------
T
Y
--
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
---
Y
G
L
T
V
E
R
A
E
R
---
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
-------------
22
PsiBlast_CBE
93.45
39%
-103
- C6 -
3R7L
3
PYRB_BACSU
E:
[1-289]
----------------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
-----
K
S
G
K
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
--
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
---
E
Y
Y
E
E
L
V
-
S
Q
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
G
A
---
R
V
L
F
S
G
P
S
-
E
W
---
Q
-
D
E
-----
E
N
T
F
---
G
------
T
Y
--
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
---
Y
G
L
T
V
E
R
A
E
R
---
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
--------------
24
PsiBlast_CBE
93.36
39%
-104
- C6 -
3R7L
3
PYRB_BACSU
C:
[1-289]
----------------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
-----
K
S
G
K
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
--
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
---
E
Y
Y
E
E
L
V
-
S
Q
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
G
A
---
R
V
L
F
S
G
P
S
-
E
W
---
Q
-
D
E
-----
E
N
T
F
---
G
------
T
Y
--
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
---
Y
G
L
T
V
E
R
A
E
R
---
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
--------------
28
PsiBlast_CBE
93.15
39%
-113
- C6 -
3R7D
4
PYRB_BACSU
C:
[1-289]
----------------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
-----
K
S
G
K
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
--
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
---
E
Y
Y
E
E
L
V
-
S
Q
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
G
A
---
R
V
L
F
S
G
P
S
-
E
W
---
Q
-
D
E
-----
E
N
T
F
---
G
------
T
Y
--
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
---
Y
G
L
T
V
E
R
A
E
R
---
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
-------------
2
PsiBlast_PDB
92.89
39%
-109
- C6 -
3R7D
3
PYRB_BACSU
A:
[1-289]
----------------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
-----
K
S
G
K
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
--
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
---
E
Y
Y
E
E
L
V
-
S
Q
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
G
A
---
R
V
L
F
S
G
P
S
-
E
W
---
Q
-
D
E
-----
E
N
T
F
---
G
------
T
Y
--
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
---
Y
G
L
T
V
E
R
A
E
R
---
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
-------------
25
PsiBlast_CBE
92.82
39%
-103
- C6 -
3R7L
3
PYRB_BACSU
B:
[1-289]
----------------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
-----
K
S
G
K
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
--
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
---
E
Y
Y
E
E
L
V
-
S
Q
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
G
A
---
R
V
L
F
S
G
P
S
-
E
W
---
Q
-
D
E
-----
E
N
T
F
---
G
------
T
Y
--
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
---
Y
G
L
T
V
E
R
A
E
R
---
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
--------------
4
PsiBlast_PDB
92.74
39%
-107
- C6 -
3R7L
3
PYRB_BACSU
A:
[1-289]
----------------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
-----
K
S
G
K
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
--
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
---
E
Y
Y
E
E
L
V
-
S
Q
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
G
A
---
R
V
L
F
S
G
P
S
-
E
W
---
Q
-
D
E
-----
E
N
T
F
---
G
------
T
Y
--
V
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
---
Y
G
L
T
V
E
R
A
E
R
---
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
--------------
46
PsiBlast_CBE
92.66
33%
-119
- C6 -
2BE7
2
?
C:
[24-321]
-----------------
K
H
I
V
S
I
N
D
I
S
R
N
E
L
E
L
I
V
K
T
A
A
K
L
K
E
Q
-----
P
Q
P
E
L
L
K
N
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
A
I
Q
R
L
G
G
S
V
I
G
F
-
D
N
-
A
GN
T
S
L
A
K
K
G
E
T
L
A
D
S
I
S
V
I
S
S
Y
A
-
D
A
F
V
M
R
H
P
Q
E
G
A
A
R
L
A
S
E
F
---
S
-
N
V
P
V
I
N
G
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
S
I
Y
E
T
Q
G
R
L
D
N
L
N
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
A
Q
A
L
A
K
F
D
G
C
K
F
H
F
I
A
P
D
A
L
A
M
P
---
E
-
Y
I
CDELD
E
Q
N
I
---
S
--
Y
--
A
T
Y
--
A
S
I
E
E
V
V
P
E
I
D
V
L
Y
M
T
R
V
Q
K
E
R
F
------
D
E
T
E
Y
Q
H
M
KAG
F
I
L
S
A
S
S
L
V
H
---
A
K
P
N
L
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
Y
A
Y
Y
F
Q
Q
A
E
N
G
V
Y
A
R
E
A
L
L
A
L
V
L
N
E
T
I
G
E
---------
78
PsiBlast_CBE
92.59
34%
-110
- C6 -
2AIR
2
PYRB_ECOLI
A:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
I
L
-
D
M
-----
L
D
E
K
---
G
--
I
A
W
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
19
PsiBlast_PDB
92.32
34%
-108
- C6 -
1RAB
-
PYRB_ECOLI
A:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
I
L
-
D
M
-----
L
D
E
K
---
G
--
I
A
W
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
11
PsiBlast_PDB
92.26
33%
-119
- C6 -
2BE7
2
?
A:
[24-321]
-----------------
K
H
I
V
S
I
N
D
I
S
R
N
E
L
E
L
I
V
K
T
A
A
K
L
K
E
Q
-----
P
Q
P
E
L
L
K
N
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
A
I
Q
R
L
G
G
S
V
I
G
F
-
D
N
-
A
GN
T
S
L
A
K
K
G
E
T
L
A
D
S
I
S
V
I
S
S
Y
A
-
D
A
F
V
M
R
H
P
Q
E
G
A
A
R
L
A
S
E
F
---
S
-
N
V
P
V
I
N
G
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
S
I
Y
E
T
Q
G
R
L
D
N
L
N
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
A
Q
A
L
A
K
F
D
G
C
K
F
H
F
I
A
P
D
A
L
A
M
P
---
E
-
Y
I
C
D
E
L
D
E
Q
N
I
---
S
--
Y
--
A
T
Y
--
A
S
I
E
E
V
V
P
E
I
D
V
L
Y
M
T
R
V
Q
K
E
R
F
------
D
E
T
E
Y
Q
H
M
KAG
F
I
L
S
A
S
S
L
V
H
---
A
K
P
N
L
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
Y
A
Y
Y
F
Q
Q
A
E
N
G
V
Y
A
R
E
A
L
L
A
L
V
L
N
E
T
I
G
E
---------
18
PsiBlast_PDB
92.20
34%
-108
- C6 -
1RAA
-
PYRB_ECOLI
A:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
I
L
-
D
M
-----
L
D
E
K
---
G
--
I
A
W
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
81
PsiBlast_CBE
91.91
34%
-108
- C6 -
1R0C
2
PYRB_ECOLI
G:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
QYI
L
-
D
M
-----
L
D
E
K
---
G
--
I
AW
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
73
PsiBlast_CBE
91.82
34%
-108
- C6 -
2FZG
1
PYRB_ECOLI
C:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
QYI
L
-
D
M
-----
L
D
E
K
---
G
--
I
AW
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
17
PsiBlast_PDB
91.70
34%
-108
- C6 -
1EKX
2
PYRB_ECOLI
A:
[8-306]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
I
L
-
D
M
-----
L
D
E
K
---
G
--
I
A
W
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
51
PsiBlast_CBE
91.54
34%
-105
- C6 -
1EKX
3
PYRB_ECOLI
B:
[8-306]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
QYI
L
-
D
M
-----
L
D
E
K
---
G
--
I
AW
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
82
PsiBlast_CBE
91.37
34%
-108
- C6 -
1R0C
2
PYRB_ECOLI
A:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
I
L
-
D
M
-----
L
D
E
K
---
G
--
I
A
W
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
69
PsiBlast_CBE
91.35
34%
-104
- C6 -
2H3E
1
PYRB_ECOLI
C:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
QYI
L
-
D
M
-----
L
D
E
K
---
G
--
I
AW
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
75
PsiBlast_CBE
91.03
34%
-106
- C6 -
2FZC
1
PYRB_ECOLI
C:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
QYI
L
-
D
M
-----
L
D
E
K
---
G
--
I
AW
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
14
PsiBlast_PDB
91.03
34%
-101
- C6 -
1D09
1
PYRB_ECOLI
A:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
E
Y
I
L
-
D
M
-----
L
D
E
K
---
G
--
I
A
W
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
74
PsiBlast_CBE
91.00
34%
-104
- C6 -
2FZG
1
PYRB_ECOLI
A:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
I
L
-
D
M
-----
L
D
E
K
---
G
--
I
A
W
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
71
PsiBlast_CBE
90.99
34%
-104
- C6 -
2FZK
1
PYRB_ECOLI
C:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
QYI
L
-
D
M
-----
L
D
E
K
---
G
--
I
AW
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
52
PsiBlast_CBE
90.95
34%
-103
- C6 -
4KH1
1
?
C:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
QYI
L
-
D
M
-----
L
D
E
K
---
G
--
I
AW
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
67
PsiBlast_CBE
90.91
34%
-105
- C6 -
2IPO
4
PYRB_ECOLI
C:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
QYI
L
-
D
M
-----
L
D
E
K
---
G
--
I
AW
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
50
PsiBlast_CBE
90.89
34%
-104
- C6 -
1EKX
3
PYRB_ECOLI
C:
[8-306]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
QYI
L
-
D
M
-----
L
D
E
K
---
G
--
I
AW
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
60
PsiBlast_CBE
90.86
34%
-104
- C6 -
4KGV
1
?
C:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
QYI
L
-
D
M
-----
L
D
E
K
---
G
--
I
AW
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
72
PsiBlast_CBE
90.82
34%
-104
- C6 -
2FZK
1
PYRB_ECOLI
A:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
I
L
-
D
M
-----
L
D
E
K
---
G
--
I
A
W
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
63
PsiBlast_CBE
90.80
34%
-106
- C6 -
4F04
1
PYRB_ECOLI
C:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
QYI
L
-
D
M
-----
L
D
E
K
---
G
--
I
AW
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
61
PsiBlast_CBE
90.77
34%
-106
- C6 -
4KGV
1
?
A:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
I
L
-
D
M
-----
L
D
E
K
---
G
--
I
A
W
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
58
PsiBlast_CBE
90.72
34%
-102
- C6 -
4KGX
1
?
C:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
QYI
L
-
D
M
-----
L
D
E
K
---
G
--
I
AW
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
80
PsiBlast_CBE
90.71
34%
-106
- C6 -
1ZA2
3
PYRB_ECOLI
A:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
I
L
-
D
M
-----
L
D
E
K
---
G
--
I
A
W
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
59
PsiBlast_CBE
90.67
34%
-105
- C6 -
4KGX
1
?
A:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
I
L
-
D
M
-----
L
D
E
K
---
G
--
I
A
W
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
64
PsiBlast_CBE
90.63
34%
-104
- C6 -
4F04
1
PYRB_ECOLI
A:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
I
L
-
D
M
-----
L
D
E
K
---
G
--
I
A
W
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
79
PsiBlast_CBE
90.60
34%
-106
- C6 -
1ZA2
2
PYRB_ECOLI
C:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
QYI
L
-
D
M
-----
L
D
E
K
---
G
--
I
AW
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
77
PsiBlast_CBE
90.54
34%
-104
- C6 -
2AIR
2
PYRB_ECOLI
G:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
QYI
L
-
D
M
-----
L
D
E
K
---
G
--
I
AW
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
70
PsiBlast_CBE
90.49
34%
-105
- C6 -
2H3E
1
PYRB_ECOLI
A:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
I
L
-
D
M
-----
L
D
E
K
---
G
--
I
A
W
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
48
PsiBlast_CBE
90.49
34%
-103
- C6 -
1D09
1
PYRB_ECOLI
C:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
EYI
L
-
D
M
-----
L
D
E
K
---
G
--
I
AW
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
53
PsiBlast_CBE
90.47
34%
-105
- C6 -
4KH1
2
?
A:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
I
L
-
D
M
-----
L
D
E
K
---
G
--
I
A
W
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
100
PsiBlast_CBE
90.35
34%
-105
- C6 -
8ATC
1
PYRB_ECOLI
A:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
E
Y
I
L
-
D
M
-----
L
D
E
K
---
G
--
I
A
W
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
49
PsiBlast_CBE
90.23
34%
-104
- C6 -
2HSE
2
PYRB_ECOLI
C:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
QYI
L
-
D
M
-----
L
D
E
K
---
G
--
I
AW
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
----
L
A
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
54
PsiBlast_CBE
90.15
34%
-105
- C6 -
4KH0
1
?
C:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
QYI
L
-
D
M
-----
L
D
E
K
---
G
--
I
AW
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
10
PsiBlast_PDB
90.07
34%
-113
- C6 -
1ML4
1
PYRB_PYRAB
A:
[6-305]
-----------------
R
D
V
I
S
I
R
D
F
S
K
E
D
I
E
T
V
L
A
T
A
E
R
-
L
E
R
E
L
K
E
K
G
Q
L
E
Y
A
K
G
K
I
L
A
T
L
F
F
E
P
S
T
R
T
R
L
S
F
E
S
A
M
H
R
L
G
G
A
V
I
G
F
A
E
A
-
S
--
T
S
S
V
K
K
G
E
S
L
R
D
T
I
K
T
V
E
Q
Y
C
-
D
V
I
V
I
R
H
P
K
E
G
A
A
R
L
A
A
E
---
V
A
-
E
V
P
V
I
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
K
K
E
F
G
R
I
D
G
L
K
I
G
L
L
G
D
L
K
Y
G
R
T
V
H
S
L
A
E
A
L
-
T
F
Y
D
V
E
L
Y
L
I
S
P
E
L
L
R
M
P
---
R
-
H
I
-----
V
E
E
L
R
E
K
G
--
M
--
K
V
V
E
T
T
T
L
E
D
V
I
G
K
L
D
V
L
Y
V
T
R
I
Q
K
E
R
-----
F
P
D
E
Q
E
Y
L
K
V
---
K
G
S
Y
Q
V
N
L
K
V
LEK
A
K
D
E
L
R
I
M
H
P
L
P
--
R
V
D
E
I
H
P
E
V
D
N
T
K
H
A
I
Y
F
R
Q
V
F
N
G
V
P
V
R
M
A
L
L
A
L
V
L
G
V
I
------------
68
PsiBlast_CBE
90.00
34%
-104
* C6 *
2IPO
2
PYRB_ECOLI
A:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
I
L
-
D
M
-----
L
D
E
K
---
G
--
I
A
W
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
55
PsiBlast_CBE
89.96
34%
-104
- C6 -
4KH0
1
?
A:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
I
L
-
D
M
-----
L
D
E
K
---
G
--
I
A
W
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
99
PsiBlast_CBE
89.79
34%
-105
- C6 -
8ATC
1
PYRB_ECOLI
C:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
EYI
L
-
D
M
-----
L
D
E
K
---
G
--
I
AW
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
76
PsiBlast_CBE
89.78
34%
-101
- C6 -
2FZC
1
PYRB_ECOLI
A:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
I
L
-
D
M
-----
L
D
E
K
---
G
--
I
A
W
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
----
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
16
PsiBlast_PDB
89.77
34%
-100
- C6 -
2HSE
4
PYRB_ECOLI
A:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
I
L
-
D
M
-----
L
D
E
K
---
G
--
I
A
W
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
----
L
A
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------
103
HHSearch
89.14
33%
-121
- C6 -
1ML4
1
PYRB_PYRAB
A:
[2-307]
-------------
D
W
K
G
R
D
V
I
S
I
R
D
F
S
K
E
D
I
E
T
V
L
A
T
A
E
R
L
E
R
E
L
K
E
-
K
G
Q
L
E
Y
A
K
G
K
I
L
A
T
L
F
F
E
P
S
T
R
T
R
L
S
F
E
S
A
M
H
R
L
G
G
A
V
I
G
F
-
A
E
A
S
--
T
S
S
V
K
K
G
E
S
L
R
D
T
I
K
T
V
E
Q
Y
-
C
D
V
I
V
I
R
H
P
K
E
G
A
A
R
L
A
A
E
V
A
----
E
V
P
V
I
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
K
K
E
F
G
R
I
D
G
L
K
I
G
L
L
G
D
L
K
Y
G
R
T
V
H
S
L
A
E
A
L
T
F
Y
D
V
-
E
L
Y
L
I
S
P
E
L
L
-
R
M
---
P
R
H
I
-----
V
E
E
L
R
E
K
G
MK
V
--
V
E
T
--
T
T
L
E
D
V
I
G
K
L
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
D
E
Q
--
E
Y
L
K
V
K
G
S
---
Y
Q
V
N
L
K
V
L
E
K
---
A
K
D
E
L
R
I
M
H
P
L
P
R
--
V
D
E
I
H
P
E
V
D
N
T
K
H
A
I
Y
F
R
Q
V
F
N
G
V
P
V
R
M
A
L
L
A
L
V
L
G
V
I
------------
15
PsiBlast_PDB
87.82
34%
-97
- C6 -
2A0F
1
PYRB_ECOLI
A:
[7-305]
-----------------
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
-----
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
V
-
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
-
L
A
T
E
F
-
S
G
-
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
I
L
-
D
M
-----
L
D
E
K
---
G
--
I
A
W
S
L
H
--
S
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
----
L
A
P
S
E
Y
A
N
V
K
A
Q--
F
V
L
R
A
S
D
L
H
N
---
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
V
L
---------