@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0420: (2016-01-04 )
MGLNADWMQRDLNVLWHPCTQMKDHERLPVIPIRRGEGVWLEDFEGKRYIDAVSSWWVNVFGHANPRINQRIKDQVDQLEHVILAGFSHQPVIELSERLVKITPPGLDRVFYADSGSAGIEVALKMSYHFWLNSGRPRKKRFVTLTNSYHGETIAAMSVGDVALFTETYKSLLLDTIKVPSPDCFLRPDGMCWEEHSRNMFAHMERTLAEGHDEIAAVIVEPLIQGAGGMRMYHPVYLKLLREACDRYGVHLIHDEIAVGFGRTGTMFACEQAGIAPDFLCLSKALTGGYLPMSAVLTSETIYRGFYDDYQTLRAFLHSHTYTGNPLACAAALATLDIFEEDKVIEANRALSTHMARATAHLADHPHVAEVRQTGMVLAIEMVQDKASRTPYPWQERRGLKVFQHGLERGALLRPLGSVVYFLPPYVITPEQIDFLAEVASEGIDIATRDAVSVAVSDFHPDHRDPG
Atome Classification :
(51 SA)
.........10........20........30........40---........50........60........70.......--.80........90........100....-...110.......120.......130....-...140.......150.......-160-----.......170.......180...------....190.......200.......210.......220-.......230.......240.......250.......260.......270........280.......290.......----300.......310.......320.......330.......340--.........350.......360...-....370.......380..--.....390-........400.......410.....-..420.......430.......440.......450.......460.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGL
N
A
D
W
M
Q
R
D
L
N
V
LWHPCTQMKDHERL
P
V
I
P
IRRGE
G
V
W
L---EDFEG
K
R
Y
I
D
A
V
S
S
W
W
V
N
V
FGHANPR
I
N
Q
R
I
K
D
Q
V
D
Q
--
L
E
H
V
I
L
AGFSHQ
P
V
I
E
L
S
E
R
L
VKITPPG-L
D
R
V
F
YADSGSA
G
I
E
V
A
L
K
M
S
Y
H
F
W
LNSGR-PR
K
K
R
F
V
T
LTNSYHG
E
T
I
A
A
M
SV-G
D
V
-----
A
L
F
T
E
T
Y
K
S
L
L
L
D
TIKVPSPD
C
F
------LRPDGM
C
W
E
E
HS
R
N
M
F
A
H
M
E
R
T
L
AE
G
H
D
E
I
A
A
V
I
V
E
P
-
L
I
QGAGGMRMY
H
P
V
Y
L
K
L
L
R
E
A
C
D
RYG
V
H
L
I
HD
E
I
AVGFGRTG
T
M
F
A
C
E
-QAGIA
P
D
F
L
C
L
S
K
A
LTGGYL
P
M
S
A
V
L
T
S
----
E
T
I
Y
R
G
F
Y
D
D
Y
Q
T
L
R
A
F
L
H
SHTYTG
N
P
L
A
C
A
A
A
L
A
T
L
D
IFE----EDKV
I
E
A
N
R
A
L
S
T
H
M
A
R
A
T
A
HLADH-P
H
V
A
E
V
R
QT
G
M
V
L
A
I
E
M
V
Q
--
D
K
ASRTP--Y
P
W
Q
ERR
G
L
K
V
F
Q
H
G
L
ERG
A
L
L
R
P
L
G
-
S
V
V
Y
FLPPYVI
T
P
E
Q
I
D
F
L
A
E
V
A
SEGI
D
I
ATR
D
A
V
S
V
A
V
S
DFHPDHRDPG
1
PsiBlast_PDB
94.21
40%
-116
- C1 -
3DOD
2
BIOK_BACSU
A:
[3-440]
----
H
D
L
I
E
K
S
K
K
H
L
W
L
P
F
T
Q
M
K
D
Y
D
E
N
P
L
I
-
I
E
S
G
T
G
I
K
V
---
K
D
I
N
G
K
E
Y
Y
D
G
F
S
S
V
W
L
N
V
H
G
H
R
K
K
E
L
D
D
A
I
K
K
Q
L
G
K
--
I
A
H
S
T
L
L
G
M
T
N
V
P
A
T
Q
L
A
E
T
L
I
D
I
S
P
K
K
-
L
T
R
V
F
Y
S
D
S
G
A
E
A
M
E
I
A
L
K
M
A
F
Q
Y
W
K
N
I
G
K
-
P
E
K
Q
K
F
I
A
M
K
-----------------------------------
S
Y
K
A
P
I
P
Y
V
Y
-------
R
S
E
S
G
D
P
D
E
C
R
D
Q
C
L
R
E
L
A
Q
L
L
E
E
H
H
E
E
I
A
A
L
S
I
E
S
-
M
V
Q
G
A
S
G
M
I
V
M
P
E
G
Y
L
A
G
V
R
E
L
C
T
T
Y
D
V
L
M
I
V
D
E
V
A
T
G
F
G
R
T
G
K
M
F
A
C
E
-
H
E
N
V
Q
P
D
L
M
A
A
G
K
G
I
T
G
G
Y
L
P
I
A
V
T
F
A
T
----
E
D
I
Y
K
A
F
Y
D
D
Y
E
N
L
K
T
F
F
H
G
H
S
Y
T
G
N
Q
L
G
C
A
V
A
L
E
N
L
A
L
F
E
----
S
E
N
I
V
E
Q
V
A
E
K
S
K
K
L
H
F
L
L
Q
D
L
H
A
L
-
P
H
V
G
D
I
R
Q
L
G
F
M
C
G
A
E
L
V
R
--
S
K
E
T
K
E
P
--
Y
P
A
D
R
R
I
G
Y
K
V
S
L
K
M
R
E
L
G
M
L
T
R
P
L
G
-
D
V
I
A
F
L
P
P
L
A
S
T
A
E
E
L
S
E
M
V
A
I
M
K
Q
A
I
H
E
V
T
S
L
E
D
---------------
32
PsiBlast_CBE
93.97
40%
-114
- C1 -
1S06
1
BIOA_ECOLI
B:
[1-425]
--
M
T
T
D
D
L
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
--
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
---
I
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
-
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
-
A
R
Q
-
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
-
C
D
P
D----
N
S
M
H
S
L
W
K
G
Y
L
P
E
N
L
F
A
P
A
P
Q
S
--------
R
M
D
G
E
-
W
D
E
R
D
M
V
G
F
A
---
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
K
T
G
K
L
F
A
C
E
-
H
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
N
G
------
E
A
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
----
S
G
D
W
Q
Q
Q
V
A
D
I
E
V
Q
L
R
E
Q
L
A
P
A
R
D
A
-
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
----------
T
T
--
H
P
V
N
M
A
A
L
Q
K
F
F
---
V
E
Q
G
V
W
I
R
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
----------------
23
PsiBlast_CBE
93.79
41%
-114
- C1 -
1QJ5
3
BIOA_ECOLI
B:
[1-425]
--
M
T
T
D
D
L
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
--
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
---
I
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
-
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
-
A
R
Q
-
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
-
C
D
P
D----
N
S
M
H
S
L
W
K
G
Y
L
P
E
N
L
F
A
P
A
P
Q
S
--------
R
M
D
G
E
-
W
D
E
R
D
M
V
G
F
A
---
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
-
H
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
N
G
------
E
A
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
----
S
G
D
W
Q
Q
Q
V
A
D
I
E
V
Q
L
R
E
Q
L
A
P
A
R
D
A
-
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
----------
T
T
--
H
P
V
N
M
A
A
L
Q
K
F
F
---
V
E
Q
G
V
W
I
R
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
Q
---------------
21
PsiBlast_CBE
93.56
40%
-115
- C1 -
3DOD
2
BIOK_BACSU
B:
[4-440]
-----
D
L
I
E
K
S
K
K
H
L
W
L
P
F
T
Q
M
K
D
Y
D
E
N
P
L
I
-
I
E
S
G
T
G
I
K
V
---
K
D
I
N
G
K
E
Y
Y
D
G
F
S
S
V
W
L
N
V
H
G
H
R
K
K
E
L
D
D
A
I
K
K
Q
L
G
K
--
I
A
H
S
T
L
L
G
M
T
N
V
P
A
T
Q
L
A
E
T
L
I
D
I
S
P
K
K
-
L
T
R
V
F
Y
S
D
S
G
A
E
A
M
E
I
A
L
K
M
A
F
Q
Y
W
K
N
I
G
K
-
P
E
K
Q
K
F
I
A
M
K
-----------------------------------
S
Y
K
A
P
I
P
Y
V
Y
-------
R
S
E
S
G
D
P
D
E
C
R
D
Q
C
L
R
E
L
A
Q
L
L
E
E
H
H
E
E
I
A
A
L
S
I
E
S
-
M
V
Q
G
A
S
G
M
I
V
M
P
E
G
Y
L
A
G
V
R
E
L
C
T
T
Y
D
V
L
M
I
V
D
E
V
A
T
G
F
G
R
T
G
K
M
F
A
C
E
-
H
E
N
V
Q
P
D
L
M
A
A
G
K
G
I
T
G
G
Y
L
P
I
A
V
T
F
A
T
----
E
D
I
Y
K
A
F
Y
D
D
Y
E
N
L
K
T
F
F
H
G
H
S
Y
T
G
N
Q
L
G
C
A
V
A
L
E
N
L
A
L
F
E
----
S
E
N
I
V
E
Q
V
A
E
K
S
K
K
L
H
F
L
L
Q
D
L
H
A
L
-
P
H
V
G
D
I
R
Q
L
G
F
M
C
G
A
E
L
V
R
--
S
K
E
T
K
E
P
--
Y
P
A
D
R
R
I
G
Y
K
V
S
L
K
M
R
E
L
G
M
L
T
R
P
L
G
-
D
V
I
A
F
L
P
P
L
A
S
T
A
E
E
L
S
E
M
V
A
I
M
K
Q
A
I
H
E
V
T
S
L
E
D
---------------
25
PsiBlast_CBE
93.47
41%
-113
- C1 -
1MLZ
4
BIOA_ECOLI
B:
[1-425]
--
M
T
T
D
D
L
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
--
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
---
I
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
-
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
-
A
R
Q
-
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
-
C
D
P
D----
N
S
M
H
S
L
W
K
G
Y
L
P
E
N
L
F
A
P
A
P
Q
S
--------
R
M
D
G
E
-
W
D
E
R
D
M
V
G
F
A
---
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
-
H
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
N
G
------
E
A
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
----
S
G
D
W
Q
Q
Q
V
A
D
I
E
V
Q
L
R
E
Q
L
A
P
A
R
D
A
-
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
----------
T
T
--
H
P
V
N
M
A
A
L
Q
K
F
F
---
V
E
Q
G
V
W
I
R
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
----------------
30
PsiBlast_CBE
93.42
41%
-115
- C1 -
1S08
1
BIOA_ECOLI
B:
[1-425]
--
M
T
T
D
D
L
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
--
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
---
I
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
-
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
-
A
R
Q
-
R
F
L
T
F
R
N
G
Y
H
G
N
T
F
G
A
M
S
V
-
C
D
P
------------------
N
L
F
A
P
A
P
Q
S
--------
R
M
D
G
E
-
W
D
E
R
D
M
V
G
F
A
---
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
-
H
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
REVA
E
T
I
S
N
----------
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
----
S
G
D
W
Q
Q
Q
V
A
D
I
E
V
Q
L
R
E
Q
L
A
P
A
R
D
A
-
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
----------
T
T
--
H
P
V
N
M
A
A
L
Q
K
F
F
---
V
E
Q
G
V
W
I
R
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
----------------
27
PsiBlast_CBE
93.27
41%
-112
- C1 -
1S07
4
BIOA_ECOLI
B:
[1-425]
--
M
T
T
D
D
L
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
--
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
---
I
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
-
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
-
A
R
Q
-
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
-
C
D
P
D----
N
S
M
H
S
L
W
K
G
Y
L
P
E
N
L
F
A
P
A
P
Q
S
--------
R
M
D
G
E
-
W
D
E
R
D
M
V
G
F
A
---
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
A
T
G
K
L
F
A
C
E
-
H
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
REVA
E
T
I
S
N
G
------
E
A
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
----
S
G
D
W
Q
Q
Q
V
A
D
I
E
V
Q
L
R
E
Q
L
A
P
A
R
D
A
-
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
----------
T
T
--
H
P
V
N
M
A
A
L
Q
K
F
F
---
V
E
Q
G
V
W
I
R
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
----------------
26
PsiBlast_CBE
93.21
41%
-113
- C1 -
1MLY
4
BIOA_ECOLI
B:
[1-425]
--
M
T
T
D
D
L
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
--
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
---
I
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
-
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
-
A
R
Q
-
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
-
C
D
P
D----
N
S
M
H
S
L
W
K
G
Y
L
P
E
N
L
F
A
P
A
P
Q
S
--------
R
M
D
G
E
-
W
D
E
R
D
M
V
G
F
A
---
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
-
H
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
N
G
------
E
A
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
----
S
G
D
W
Q
Q
Q
V
A
D
I
E
V
Q
L
R
E
Q
L
A
P
A
R
D
A
-
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
----------
T
T
--
H
P
V
N
M
A
A
L
Q
K
F
F
---
V
E
Q
G
V
W
I
R
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
----------------
2
PsiBlast_PDB
93.00
40%
-115
- C1 -
3DRD
-
BIOK_BACSU
A:
[1-440]
--
M
T
H
D
L
I
E
K
S
K
K
H
L
W
L
P
F
T
Q
M
K
D
Y
D
E
N
P
L
I
-
I
E
S
G
T
G
I
K
V
---
K
D
I
N
G
K
E
Y
Y
D
G
F
S
S
V
W
L
N
V
H
G
H
R
K
K
E
L
D
D
A
I
K
K
Q
L
G
K
--
I
A
H
S
T
L
L
G
M
T
N
V
P
A
T
Q
L
A
E
T
L
I
D
I
S
P
K
K
-
L
T
R
V
F
Y
S
D
S
G
A
E
A
M
E
I
A
L
K
M
A
F
Q
Y
W
K
N
I
G
K
-
P
E
K
Q
K
F
I
A
M
K
-----------------------------------
S
Y
K
A
P
I
P
Y
V
Y
-------
R
S
E
S
G
D
P
D
E
C
R
D
Q
C
L
R
E
L
A
Q
L
L
E
E
H
H
E
E
I
A
A
L
S
I
E
S
-
M
V
Q
G
A
S
G
M
I
V
M
P
E
G
Y
L
A
G
V
R
E
L
C
T
T
Y
D
V
L
M
I
V
D
E
V
A
T
G
F
G
R
T
G
K
M
F
A
C
E
-
H
E
N
V
Q
P
D
L
M
A
A
G
K
G
I
T
G
G
Y
L
P
I
A
V
T
F
A
T
----
E
D
I
Y
K
A
F
Y
D
D
Y
E
N
L
K
T
F
F
H
G
H
S
Y
T
G
N
Q
L
G
C
A
V
A
L
E
N
L
A
L
F
E
----
S
E
N
I
V
E
Q
V
A
E
K
S
K
K
L
H
F
L
L
Q
D
L
H
A
L
-
P
H
V
G
D
I
R
Q
L
G
F
M
C
G
A
E
L
V
R
--
S
K
E
T
K
E
P
--
Y
P
A
D
R
R
I
G
Y
K
V
S
L
K
M
R
E
L
G
M
L
T
R
P
L
G
-
D
V
I
A
F
L
P
P
L
A
S
T
A
E
E
L
S
E
M
V
A
I
M
K
Q
A
I
H
E
V
T
S
L
E
D
---------------
28
PsiBlast_CBE
92.43
41%
-109
- C1 -
1MGV
7
BIOA_ECOLI
B:
[1-425]
--
M
T
T
D
D
L
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
--
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
---
I
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
-
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
-
A
R
Q
-
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
-
C
D
P
D----
N
S
M
H
S
L
W
K
G
Y
L
P
E
N
L
F
A
P
A
P
Q
S
--------
R
M
D
G
E
-
W
D
E
R
D
M
V
G
F
A
---
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
-
H
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
REVA
E
T
I
S
N
G
------
E
A
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
----
S
G
D
W
Q
Q
Q
V
A
D
I
E
V
Q
L
R
E
Q
L
A
P
A
R
D
A
-
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
----------
T
T
--
H
P
V
N
M
A
A
L
Q
K
F
F
---
V
E
Q
G
V
W
I
A
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
----------------
31
PsiBlast_CBE
92.28
40%
-110
- C1 -
1S09
1
BIOA_ECOLI
B:
[1-425]
--
M
T
T
D
D
L
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
--
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
---
I
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
-
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
-
A
R
Q
-
R
F
L
T
F
R
N
G
F
H
G
D
T
F
G
A
M
S
V
-
C
D
P
D----
N
S
M
H
S
L
W
K
G
Y
L
P
E
N
L
F
A
P
A
P
Q
S
--------
R
M
D
G
E
-
W
D
E
R
D
M
V
G
F
A
---
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
-
H
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
N
G
------
E
A
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
----
S
G
D
W
Q
Q
Q
V
A
D
I
E
V
Q
L
R
E
Q
L
A
P
A
R
D
A
-
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
----------
T
T
--
H
P
V
N
M
A
A
L
Q
K
F
F
---
V
E
Q
G
V
W
I
R
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
----------------
4
PsiBlast_PDB
91.91
41%
-110
- C1 -
1MGV
5
BIOA_ECOLI
A:
[1-425]
--
M
T
T
D
D
L
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
--
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
---
I
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
-
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
-
A
R
Q
-
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
-
C
D
P
D----
N
S
M
H
S
L
W
K
G
Y
L
P
E
N
L
F
A
P
A
P
Q
S
--------
R
M
D
G
E
-
W
D
E
R
D
M
V
G
F
A
---
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
-
H
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
N
G
------
E
A
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
----
S
G
D
W
Q
Q
Q
V
A
D
I
E
V
Q
L
R
E
Q
L
A
P
A
R
D
A
-
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
----------
T
T
--
H
P
V
N
M
A
A
L
Q
K
F
F
---
V
E
Q
G
V
W
I
A
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
----------------
5
PsiBlast_PDB
91.88
41%
-111
- C1 -
1S07
4
BIOA_ECOLI
A:
[1-425]
--
M
T
T
D
D
L
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
--
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
---
I
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
-
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
-
A
R
Q
-
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
-
C
D
P
D----
N
S
M
H
S
L
W
K
G
Y
L
P
E
N
L
F
A
P
A
P
Q
S
--------
R
M
D
G
E
-
W
D
E
R
D
M
V
G
F
A
---
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
A
T
G
K
L
F
A
C
E
-
H
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
N
G
------
E
A
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
----
S
G
D
W
Q
Q
Q
V
A
D
I
E
V
Q
L
R
E
Q
L
A
P
A
R
D
A
-
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
----------
T
T
--
H
P
V
N
M
A
A
L
Q
K
F
F
---
V
E
Q
G
V
W
I
R
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
Q
---------------
29
PsiBlast_CBE
91.69
41%
-112
- C1 -
1S0A
1
BIOA_ECOLI
B:
[1-425]
--
M
T
T
D
D
L
A
F
D
Q
R
H
I
L
H
P
F
T
S
M
T
S
--
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
---
I
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
-
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
-
A
R
Q
-
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
-
C
D
P
D----
N
S
M
H
S
L
W
K
G
Y
L
P
E
N
L
F
A
P
A
P
Q
S
--------
R
M
D
G
E
-
W
D
E
R
D
M
V
G
F
A
---
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
-
H
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
N
G
------
E
A
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
----
S
G
D
W
Q
Q
Q
V
A
D
I
E
V
Q
L
R
E
Q
L
A
P
A
R
D
A
-
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
----------
T
T
--
H
P
V
N
M
A
A
L
Q
K
F
F
---
V
E
Q
G
V
W
I
R
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
----------------
24
PsiBlast_CBE
91.52
41%
-113
- C1 -
1QJ3
5
BIOA_ECOLI
B:
[1-425]
--
M
T
T
D
D
L
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
--
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
---
I
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
-
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
-
A
R
Q
-
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
-
C
D
P
D----
N
---------
L
P
E
N
L
F
A
P
A
P
Q
S
--------
R
M
--
E
-
W
D
E
R
D
M
V
G
F
A
---
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
-
H
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
N
G
--------
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
----
S
G
D
W
Q
Q
Q
V
A
D
I
E
V
Q
L
R
E
Q
L
A
P
A
R
D
A
-
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
----------
T
T
--
H
P
V
N
M
A
A
L
Q
K
F
F
---
V
E
Q
G
V
W
I
R
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
----------------
74
HHSearch
90.59
39%
-113
- C1 -
3DOD
2
BIOK_BACSU
A:
[3-445]
----
H
D
L
I
E
K
S
K
K
H
L
W
L
P
F
T
Q
M
K
D
Y
D
E
-
N
P
L
I
I
E
S
G
T
G
I
K
V
---
K
D
I
N
G
K
E
Y
Y
D
G
F
S
S
V
W
L
N
V
H
G
H
R
K
K
E
L
D
D
A
I
K
K
Q
L
G
K
--
I
A
H
S
T
L
L
G
M
T
N
V
P
A
T
Q
L
A
E
T
L
I
D
I
S
-
P
K
K
L
T
R
V
F
Y
S
D
S
G
A
E
A
M
E
I
A
L
K
M
A
F
Q
Y
W
K
N
I
G
K
-
P
E
K
Q
K
F
I
A
M
K
-----------------------------------
S
Y
K
A
P
I
P
Y
V
Y
------
R
S
E
S
G
D
-
P
D
E
C
R
D
Q
C
L
R
E
L
A
Q
L
L
E
E
H
H
E
E
I
A
A
L
S
I
E
S
M
V
-
Q
G
A
S
G
M
I
V
M
P
E
G
Y
L
A
G
V
R
E
L
C
T
T
Y
D
V
L
M
I
V
D
E
V
A
T
G
F
G
R
T
G
K
M
F
A
C
E
H
E
-
N
V
Q
P
D
L
M
A
A
G
K
G
I
T
G
G
Y
L
P
I
A
V
T
F
A
T
----
E
D
I
Y
K
A
F
Y
D
D
Y
E
N
L
K
T
F
F
H
G
H
S
Y
T
G
N
Q
L
G
C
A
V
A
L
E
N
L
A
L
F
E
----
S
E
N
I
V
E
Q
V
A
E
K
S
K
K
L
H
F
L
L
Q
D
L
H
A
L
-
P
H
V
G
D
I
R
Q
L
G
F
M
C
G
A
E
L
V
R
--
S
K
E
T
K
E
P
YP
A
D
R
R
I
G
--
Y
K
V
S
L
K
M
R
E
L
G
M
L
T
R
P
L
G
-
D
V
I
A
F
L
P
P
L
A
S
T
A
E
E
L
S
E
M
V
A
I
M
K
Q
A
I
H
E
V
T
S
L
E
D
---------------
22
PsiBlast_CBE
90.13
40%
-110
- C1 -
1DTY
5
BIOA_ECOLI
B:
[1-425]
--
M
T
T
D
D
L
A
F
D
E
R
H
I
W
H
P
Y
T
S
M
T
S
--
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
---
I
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
E
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
-
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
D
A
K
G
E
-
A
R
D
-
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
-
C
D
P
D----
N
S
M
H
S
L
W
K
G
Y
L
P
E
N
L
F
A
P
A
P
Q
S
--------
R
M
D
G
E
-
W
D
E
R
D
M
V
G
F
A
---
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
-
H
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
----
R
E
V
A
E
T
I
S
D
G
E
A
G
--
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
----
S
G
D
W
Q
Q
Q
V
A
D
I
E
V
Q
L
R
E
Q
L
A
P
A
R
D
A
-
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
----------
T
T
--
H
P
V
N
M
A
A
L
Q
K
F
F
---
V
E
Q
G
V
W
I
R
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
Q
---------------
3
PsiBlast_PDB
89.55
40%
-109
- C1 -
1DTY
5
BIOA_ECOLI
A:
[1-425]
--
M
T
T
D
D
L
A
F
D
E
R
H
I
W
H
P
Y
T
S
M
T
S
--
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
---
I
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
E
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
-
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
D
A
K
G
E
-
A
R
D
-
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
-
C
D
P
D----
N
S
M
H
S
L
W
K
G
Y
L
P
E
N
L
F
A
P
A
P
Q
S
--------
R
M
D
G
E
-
W
D
E
R
D
M
V
G
F
A
---
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
-
H
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
----
R
E
V
A
E
T
I
S
D
G
E
A
G
--
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
----
S
G
D
W
Q
Q
Q
V
A
D
I
E
V
Q
L
R
E
Q
L
A
P
A
R
D
A
-
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
----------
T
T
--
H
P
V
N
M
A
A
L
Q
K
F
F
---
V
E
Q
G
V
W
I
R
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
Q
---------------
62
Fugue
85.78
39%
-108
- C1 -
1DTY
5
BIOA_ECOLI
A:
[1-429]
--
M
T
T
D
D
L
A
F
D
E
R
H
I
W
H
P
Y
T
S
M
T
S
P
L
--
P
V
Y
P
V
V
S
A
E
G
C
E
L
---
I
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
-
S
Q
I
D
A
M-
S
H
V
M
F
G
E
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
-
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
D
A
K
-
G
E-
A
R
D
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
C
D
P
D
-----
N
S
M
H
S
L
W
K
G
Y
L
P
E
N
L
F
A
P
A
P
Q
S
R
MDGEWD--------
E
R
D
M
V
G
F
A
R
L
M
A
A
H
R
H
----
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
-
H
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
----
R
E
V
A
E
T
I
S
D
G
--
E
A
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
----
S
G
D
W
Q
Q
Q
V
A
D
I
E
V
Q
L
R
E
Q
L
A
P
A
R
D
-A
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
T
T
-------
H
P
V
-----
N
---
M
A
A
L
Q
K
F
F
V
E
Q
G
V
W
I
R
P
F
-G
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
Q
---------------
7
PsiBlast_PDB
81.35
35%
-108
- C1 -
3TFT
3
BIOA_MYCTU
A:
[41-450]
--------------
L
W
H
P
Y
S
S
I
G
-----
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
PV
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
-----------------
33
PsiBlast_CBE
80.36
35%
-109
- C1 -
4W1W
8
BIOA_MYCTU
B:
[14-423]
--------------
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
TLI
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
GQDW
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
PV
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---------------
12
PsiBlast_PDB
80.05
35%
-107
- C1 -
4CXQ
8
BIOA_MYCTU
A:
[41-450]
--------------
L
W
H
P
Y
S
S
I
G
-
R
E
-
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
PV
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---------------
44
PsiBlast_CBE
79.86
35%
-109
- C1 -
4W1X
5
BIOA_MYCTU
B:
[41-450]
--------------
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
PV
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---------------
39
PsiBlast_CBE
79.85
35%
-107
- C1 -
4WYD
13
?
A:
[41-450]
--------------
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
PV
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
L
P
-------------
14
PsiBlast_PDB
79.85
35%
-108
- C1 -
4W1X
7
BIOA_MYCTU
A:
[41-450]
--------------
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
PV
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
L
--------------
10
PsiBlast_PDB
79.81
35%
-107
- C1 -
4MQQ
7
BIOA_MYCTU
A:
[41-450]
--------------
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
PV
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---------------
35
PsiBlast_CBE
79.76
35%
-107
- C1 -
4WYG
14
?
B:
[41-450]
--------------
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
TLI
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
GQDW
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
PV
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
L
--------------
36
PsiBlast_CBE
79.74
35%
-107
- C1 -
4WYF
3
?
B:
[41-450]
--------------
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
TLI
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
GQDW
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
PV
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
-----------------
47
PsiBlast_CBE
79.72
35%
-105
- C1 -
4MQP
4
BIOA_MYCTU
B:
[41-450]
--------------
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
TLI
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
GQDW
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
PV
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
----------------
13
PsiBlast_PDB
79.68
35%
-107
- C1 -
4CXR
6
BIOA_MYCTU
A:
[41-450]
--------------
L
W
H
P
Y
S
S
I
G
-
R
---
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
PV
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---------------
16
PsiBlast_PDB
79.65
35%
-107
- C1 -
4WYE
7
?
A:
[41-450]
--------------
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
PV
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
L
--------------
19
PsiBlast_PDB
79.54
35%
-106
- C1 -
4XEW
4
?
A:
[41-450]
--------------
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
PV
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---------------
8
PsiBlast_PDB
79.51
35%
-105
- C1 -
3TFU
3
BIOA_MYCTU
A:
[41-450]
--------------
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
H----------
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
P
V
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
-----------------
48
PsiBlast_CBE
79.39
35%
-105
- C1 -
4CXR
5
BIOA_MYCTU
B:
[41-450]
--------------
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
P
V
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
-----------------
53
PsiBlast_CBE
79.35
35%
-107
- C1 -
4W1V
5
BIOA_MYCTU
A:
[15-424]
--------------
L
W
H
P
Y
S
S
I
G
-
R
---
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
PV
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---------------
50
PsiBlast_CBE
79.13
35%
-107
- C1 -
3TFU
3
BIOA_MYCTU
B:
[41-450]
--------------
L
W
H
P
Y
S
S
I
------
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
H----------
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
PV
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
-----------------
6
PsiBlast_PDB
78.67
35%
-108
- C1 -
4W1W
9
BIOA_MYCTU
A:
[14-423]
--------------
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
PV
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
L
--------------
49
PsiBlast_CBE
78.64
35%
-105
- C1 -
4CXQ
7
BIOA_MYCTU
B:
[41-450]
--------------
L
W
H
P
Y
S
S
I
G
-
R
E
--
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
PV
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---------------
15
PsiBlast_PDB
78.47
35%
-107
- C1 -
4WYC
7
?
A:
[41-450]
--------------
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
PV
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---------------
37
PsiBlast_CBE
78.39
35%
-105
- C1 -
4WYE
7
?
B:
[41-450]
--------------
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
P
V
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---------------
45
PsiBlast_CBE
78.27
35%
-106
- C1 -
4MQR
4
BIOA_MYCTU
B:
[41-450]
--------------
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
PV
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---------------
9
PsiBlast_PDB
78.23
35%
-106
- C1 -
4MQP
4
BIOA_MYCTU
A:
[41-450]
--------------
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
P
V
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---------------
52
PsiBlast_CBE
78.19
35%
-106
- C1 -
4W1V
9
BIOA_MYCTU
B:
[15-424]
--------------
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
P
V
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---------------
51
PsiBlast_CBE
78.12
35%
-106
- C1 -
3TFT
3
BIOA_MYCTU
B:
[41-450]
--------------
L
W
H
P
Y
S
S
I
G
-
R
---
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
P
V
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
-----------------
18
PsiBlast_PDB
78.09
35%
-106
- C1 -
4WYG
10
?
A:
[41-450]
--------------
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
PV
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
L
--------------
34
PsiBlast_CBE
78.06
35%
-105
- C1 -
4XEW
4
?
B:
[41-450]
--------------
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
TLI
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
GQDW
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
PV
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---------------
38
PsiBlast_CBE
77.95
35%
-105
- C1 -
4WYD
10
?
B:
[41-450]
--------------
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
P
V
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
L
--------------
17
PsiBlast_PDB
77.83
35%
-106
- C1 -
4WYF
3
?
A:
[41-450]
--------------
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
PV
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---------------
40
PsiBlast_CBE
77.82
35%
-108
- C1 -
4WYC
8
?
B:
[41-450]
--------------
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
PV
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---------------
46
PsiBlast_CBE
77.79
35%
-105
- C1 -
4MQQ
4
BIOA_MYCTU
B:
[41-450]
--------------
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
P
V
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
----------------
11
PsiBlast_PDB
77.48
35%
-108
- C1 -
4MQR
4
BIOA_MYCTU
A:
[41-450]
--------------
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
-
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
HGGMH
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-
Q
V
P
-------------------
R
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
----
A
D
V
A
H
T
I
--
S
A
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
-
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
PV
D
L
A
V
A
T
P
--
A
-------------
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
---
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---------------