@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0428: (2016-01-04 )
MSFSSLGLSEALARAVEAAGYSQPTPVQQRAIPAVLQGRDLMVAAQTGTGKTGGFALPVLERLFPAGHPDREHRHGPRQARVLVLTPTRELAAQVHDSFKVYARDLPLNSTCIFGGVGMNPQIQALAKGVDVLVACPGRLLDLAGQNKVDLSHVEILVLDEADRMLDMGFIHDVKKVLAKLPPKRQNLLFSATFSKDIVDLANKLLHNPERIEVTPPNTTVERIEQRVFRLPAPQKRALLAHLVTVGAWEQVLVFTRTKHGANRLAEYLTKHGLPAAAIHGNKSQNARTKALADFKANDVRILVATDIAARGLDIDQLPHVVNYELPNVEEDYVHRIGRTGRAGRSGEAISLVAPDEEKLLKAIEKMTRQRIPDGDAQGFDPEAVLPEVAQPEPREAPQKQPRRDKERRSSRERKPKDAQASNPDSNVAAAQDGTEKPAGKRRRRGGKNKENREAGQAQQPRQSREARPAKPNRPPEVDGNRDPEEFLDDDFDNFGNRADYVSPYQGQENKGRGRRGGQQKPQGGTGQQGRGQGQGQARGKSQGAAQGGARGQGAGQGKAKKPRAGKPRGQGRENASRMSDAPLREPSEYGTGKQPSRQPVVINKRDLVRMDRFPTAEQLDELEPRRKGERPALLTRNR
Atome Classification :
(26 SA)
.........10........20........30.......--.40........50........60......-----..70--------..-......80--........90......-..100.......110..-.....120.......130.......140.......150.......160......-.170.......180.----.--.------.--.....190.......200.......210.......220.......230-...-....--240...-....250.......260.......270.......280.......290.......300.......310.......320.......330-----........340.......350..-...-..360.----...------...---370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
F
S
SL
G
L
S
E
A
L
A
R
A
V
E
AAGYSQPTP
V
Q
Q
R
A
I
P
A
V
LQG--R
D
L
M
V
A
A
QTGTGKTGG
F
A
L
P
V
L
E
R
LFPAG-----HPDR--------EH-RHGPR
Q
A
R
--
V
L
V
LT
P
T
R
E
L
A
A
Q
V
H
D
-
S
F
K
V
Y
ARDLPLNS
T
C
I
F-GGVGM
N
P
Q
I
Q
A
L
AKGV
D
V
L
VACP
G
R
L
L
DLAGQNKVD
L
S
H
V
E
I
L
V
LDEA
D
R
M
L
D
M
-
G
F
I
H
D
V
K
K
V
L
A
K--L----P--P------K--RQ
N
L
L
F
SATF
S
K
D
I
V
D
L
A
N
K
LLHNP
E
R
I
E
VTPPN
T
T
V
E
R
I
E
Q
R
V
FRLP-A
P
Q
-
K
R
A
L
--
L
A
H
L
V
T
-VG
A
W
E
Q
V
L
V
F
T
RTKH
G
A
N
R
L
A
E
Y
L
T
KHGL
P
A
A
A
IHGNKSQNA
R
T
K
A
L
ADFKAN
D
V
R
I
L
V
ATDIAARGL
D
I
D
QLP
H
V
VNYELPNV
E
E
------
D
Y
V
H
RIGRTGRAGRSG
E
A
I
S
L
VA-P
D
E
-
E
K
L
L
K
A
----
I
E
K
------
M
T
R
---
Q
RIPDGDAQGFDPEAVLPEVAQPEPREAPQKQPR
R
D
K
E
R
R
SSRERKPKDAQASNPDSNVAAAQDGTEKPA
G
K
R
R
RRGGKNKENREAGQAQQPRQSREARPAKPNRPPEVDGNR
D
P
E
E
F
L
D
D
D
F
D
NFGNRADYVSPYQGQENKGRGRRGGQQKPQGGTGQQGRGQGQGQARGKSQGAAQGGARGQGAGQGKAKKPRAGKPRGQGRE
N
A
S
RMSDAPLREPSEYGTGKQPSRQ
P
V
V
I
N
K
R
D
L
V
RMDRFP
T
A
E
Q
L
D
E
L
EPRRKGERPALLTRNR
5
PsiBlast_PDB
89.50
39%
-100
- C3 -
4D26
4
?
A:
[51-430]
-
S
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
G
--
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
L
-
Q
D
-----
P
K
D
L
--------
I
S
-
E
N
G
C
A
Q
P
Q
--
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
-
E
A
R
K
F
S
Y
G
S
V
L
K
V
A
V
A
Y
-
G
G
T
A
V
R
H
Q
G
D
N
I
A
R
G
C
H
I
L
V
A
T
P
G
R
L
H
D
F
V
E
R
N
R
V
S
F
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
D
M
-
G
F
M
P
S
I
E
K
M
M
----
L
----
H
--
P
TMVETT
K
--
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
G
G
A
S
T
D
V
E
Q
I
F
I
E
V
T
-
K
Y
E
-
K
R
N
S
--
L
K
Q
L
I
E
-
E
N
D
G
K
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
S
I
D
------
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
-
S
D
Q
-
D
L
A
L
V
A
D
---
L
S
K
------
I
L
R
Q
A
D
Q
S
V
P
D
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
89.45
39%
-102
- C3 -
4D25
4
?
A:
[51-430]
-
S
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
G
--
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
L
-
Q
D
-----
P
K
D
L
--------
I
S
-
E
N
G
C
A
Q
P
Q
--
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
-
E
A
R
K
F
S
Y
G
S
V
L
K
V
A
V
A
Y
-
G
G
T
A
V
R
H
Q
G
D
N
I
A
R
G
C
H
I
L
V
A
T
P
G
R
L
H
D
F
V
E
R
N
R
V
S
F
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
D
M
-
G
F
M
P
S
I
E
K
M
M
----
L
----
H
--
P
TMVETT
K
--
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
G
G
A
S
T
D
V
E
Q
I
F
I
E
V
T
-
K
Y
E
-
K
R
N
S
--
L
K
Q
L
I
E
-
E
N
D
G
K
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
S
I
D
------
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
-
S
D
Q
-
D
L
A
L
V
A
D
---
L
S
K
------
I
L
R
Q
A
D
Q
S
V
P
D
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
88.85
41%
-121
- C3 -
2I4I
1
DDX3X_HUMAN
A:
[16-379]
-
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
G
PG
E
A
L
R
A
M
K
--------
E
N
G
R
Y
G
R
R
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
-
E
A
R
K
F
S
Y
R
S
R
V
R
P
C
V
V
Y
-
G
G
A
D
I
G
Q
Q
I
R
D
L
E
R
G
C
H
L
L
V
A
T
P
G
R
L
V
D
M
M
E
R
G
K
I
G
L
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
D
M
-
G
F
E
P
Q
I
R
R
I
V
E
Q
DT
M
----
P
--
P
------
K
GV
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
----
T
S
E
N
I
T
Q
K
V
V
W
V
E
-
E
S
D
-
K
R
S
F
--
L
L
D
L
L
N
A
T
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
D
I
E
------
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
N
-
E
R
N
-
I
N
I
T
K
D
----
L
L
D
------
L
L
V
---
E
A
K
Q
E
V
P
S
W
L
E
N
M
A
Y
E
H
H
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
HHSearch
88.19
39%
-118
- C3 -
2I4I
1
DDX3X_HUMAN
A:
[16-395]
-
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
G
-----
P
G
E
A
L
R
A
M
K
E
NG
R
Y
-
G
R
R
K
Q
Y
P
I
--
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
-
E
A
R
K
F
S
Y
R
S
R
V
R
P
C
V
V
Y
-
G
G
A
D
I
G
Q
Q
I
R
D
L
E
R
G
C
H
L
L
V
A
T
P
G
R
L
V
D
M
M
E
R
G
K
I
G
L
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
D
M
-
G
F
E
P
Q
I
R
R
I
V
E
Q
--
D
TMPP
K
--
G
------
V
--
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
----
T
S
E
N
I
T
Q
K
V
V
W
V
E
-
E
S
D
-
K
R
S
F
--
L
L
D
L
L
N
A
T
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
D
I
E
------
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
N
-
E
R
N
-
I
N
I
T
K
D
----
L
L
D
------
L
L
V
---
E
A
K
Q
E
V
P
S
W
L
E
N
M
A
Y
E
H
H
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
87.28
43%
-115
- C3 -
4KBF
1
?
B:
[1-361]
M
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
A
P
S
---------------------
Q
E
R
G
R
K
P
R
--
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
-
E
L
T
A
V
A
P
H
--
L
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
L
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
-
G
F
E
E
E
V
E
A
L
L
S
A
--
T
----
P
--
P
------
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
-
K
D
E
P
V
T
Y
E
E
E
A
V
---
P
-
A
P
V
-
R
G
R
L
EV
L
S
D
L
L
Y
-
V
A
S
P
D
R
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
R
A
E
------
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
-
P
R
E
-
R
R
D
V
E
A
----
L
E
R
------
A
V
G
---
R
R
F
K
R
V
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
87.22
43%
-104
- C3 -
4KBG
4
?
B:
[1-361]
M
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
A
P
S
---------------------
Q
E
R
G
R
K
P
R
--
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
-
E
L
T
A
V
A
P
H
--
L
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
L
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
-
G
F
E
E
E
V
E
A
L
L
S
A
--
T
----
P
--
P
------
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
-
K
D
E
P
V
T
Y
E
E
E
A
V
---
P
-
A
P
V
-
R
G
R
L
EV
L
S
D
L
L
Y
-
V
A
S
P
D
R
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
R
A
E
------
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
-
P
R
E
-
R
R
D
V
E
A
----
L
E
R
------
A
V
G
---
R
R
F
K
R
V
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.01
37%
-102
- C3 -
2DB3
3
VASA1_DROME
A:
[58-429]
--
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
L
E
D
P
-----
H
-----------
E
L
-
E
L
G
--
R
P
Q
--
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
-
E
A
R
K
F
A
F
E
S
Y
L
K
I
G
I
V
Y
-
G
G
T
S
F
R
H
Q
N
E
C
I
T
R
G
C
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
R
T
F
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
D
M
-
G
F
S
E
D
M
R
R
I
M
T
H
--
V
----
T
MR
P
------
E
--
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
G
G
A
C
S
D
V
K
Q
T
I
Y
E
V
N
-
K
Y
A
-
K
R
S
K
--
L
I
E
I
L
S
-
E
Q
A
-
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
K
I
D
------
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
-
P
E
K
-
D
R
A
I
A
A
D
L
V
K
I
L
E
------
G
S
G
---
Q
T
V
P
D
F
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
86.73
37%
-102
- C3 -
2DB3
3
VASA1_DROME
D:
[58-429]
--
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
L
E
D
P
-----
H
-----------
E
L
-
E
L
G
--
R
P
Q
--
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
-
E
A
R
K
F
A
F
E
S
Y
L
K
I
G
I
V
Y
-
G
G
T
S
F
R
H
Q
N
E
C
I
T
R
G
C
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
R
T
F
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
D
M
-
G
F
S
E
D
M
R
R
I
M
T
H
--
V
----
T
MR
P
------
E
--
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
G
G
A
C
S
D
V
K
Q
T
I
Y
E
V
N
-
K
Y
A
-
K
R
S
K
--
L
I
E
I
L
S
-
E
Q
A
-
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
K
I
D
------
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
-
P
E
K
-
D
R
A
I
A
A
DLVK
I
L
E
------
G
S
G
---
Q
T
V
P
D
F
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
86.56
37%
-102
- C3 -
2DB3
3
VASA1_DROME
C:
[58-429]
--
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
L
E
D
P
-----
H
-----------
E
L
-
E
L
G
--
R
P
Q
--
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
-
E
A
R
K
F
A
F
E
S
Y
L
K
I
G
I
V
Y
-
G
G
T
S
F
R
H
Q
N
E
C
I
T
R
G
C
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
R
T
F
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
D
M
-
G
F
S
E
D
M
R
R
I
M
T
H
--
V
----
T
MR
P
------
E
--
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
G
G
A
C
S
D
V
K
Q
T
I
Y
E
V
N
-
K
Y
A
-
K
R
S
K
--
L
I
E
I
L
S
-
E
Q
A
-
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
K
I
D
------
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
-
P
E
K
-
D
R
A
I
A
A
DLVK
I
L
E
------
G
S
G
---
Q
T
V
P
D
F
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
86.33
37%
-101
- C3 -
2DB3
3
VASA1_DROME
B:
[58-429]
--
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
L
E
D
P
-----
H
-----------
E
L
-
E
L
G
--
R
P
Q
--
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
-
E
A
R
K
F
A
F
E
S
Y
L
K
I
G
I
V
Y
-
G
G
T
S
F
R
H
Q
N
E
C
I
T
R
G
C
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
R
T
F
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
D
M
-
G
F
S
E
D
M
R
R
I
M
T
H
--
V
----
T
MR
P
------
E
--
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
G
G
A
C
S
D
V
K
Q
T
I
Y
E
V
N
-
K
Y
A
-
K
R
S
K
--
L
I
E
I
L
S
-
E
Q
A
-
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
K
I
D
------
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
-
P
E
K
-
D
R
A
I
A
A
DLVK
I
L
E
------
G
S
G
---
Q
T
V
P
D
F
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
HHSearch
85.94
37%
-106
- C3 -
2DB3
3
VASA1_DROME
A:
[57-420]
-
H
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
L
E
D
P
-----
H
E
--------------
L
E
L
G
R
P
Q
--
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
-
E
A
R
K
F
A
F
E
S
Y
L
K
I
G
I
V
Y
-
G
G
T
S
F
R
H
Q
N
E
C
I
T
R
G
C
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
R
T
F
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
D
M
-
G
F
S
E
D
M
R
R
I
M
T
H
--
V
----
T
MR
P
------
E
--
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
G
G
A
C
S
D
V
K
Q
T
I
Y
E
V
N
-
K
Y
A
-
K
R
S
K
--
L
I
E
I
L
S
--
E
Q
A
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
K
I
D
------
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
-
P
E
K
D
R
A
I
A
A
D
----
L
V
K
------
I
L
E
---
G
S
G
Q
T
V
P
D
F
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
85.62
43%
-101
- C3 -
4KBF
3
?
A:
[1-361]
M
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
A
P
S
---------------------
Q
E
R
G
R
K
P
R
--
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
-
E
L
T
A
V
A
P
H
--
L
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
L
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
-
G
F
E
E
E
V
E
A
L
L
S
A
--
T
----
P
--
P
------
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
-
K
D
E
P
V
T
Y
E
E
E
A
V
---
P
-
A
P
V
-
R
G
R
L
E
V
L
S
D
L
L
Y
-
V
A
S
P
D
R
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
R
A
E
------
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
-
P
R
E
-
R
R
D
V
E
A
----
L
E
R
------
A
V
G
---
R
R
F
K
R
V
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
85.09
33%
-105
- C3 -
3PEY
11
DBP5_YEAST
A:
[6-383]
-
S
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
N
P
----------------------
E
D
A
S
P
Q
A
----
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
-
V
V
Q
E
M
G
K
F
T
K
I
T
S
Q
L
I
V
P
D
S
F
E
K
N
K
Q
I
N
A
-----
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
R
R
K
L
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
D
Q
Q
G
L
G
D
Q
C
I
R
V
K
R
F
--
L
----
P
--
K
------
D
--
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
T
N
E
V
N
V
D
A
I
K
Q
L
Y
M
D
C
K
N
E
A
D
-
K
F
D
V
--
L
T
E
L
Y
G
-
L
M
T
I
G
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
L
A
N
GQAD
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
S
-
F
N
I
L
S
A
----
I
Q
K
Y
F
GD
I
E
M
T
R
---
V
P
T
D
D
W
D
E
V
E
K
I
V
K
K
V
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
85.09
33%
-113
- C3 -
3RRM
1
DBP5_YEAST
A:
[11-383]
------
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
N
P
----------------------
E
D
A
S
P
Q
A
----
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
-
V
V
Q
E
M
G
K
F
T
K
I
T
S
Q
L
I
V
P
D
S
F
E
K
N
K
Q
I
N
A
-----
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
R
R
K
L
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
D
Q
Q
G
L
G
D
Q
C
I
R
V
K
R
F
--
L
----
P
--
K
------
D
--
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
----
V
N
V
D
A
I
K
Q
L
Y
M
D
C
K
N
E
A
D
-
K
F
D
V
--
L
T
E
L
Y
G
-
V
M
T
I
G
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
------
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
L
A
N
GQAD
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
S
-
F
N
I
L
S
A
----
I
Q
K
Y
F
GD
I
E
M
T
R
---
V
P
T
D
D
W
D
E
V
E
K
I
V
K
K
V
L
K
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
85.03
33%
-111
- C3 -
3RRN
2
DBP5_YEAST
A:
[6-383]
-
S
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
N
P
----------------------
E
D
A
S
P
Q
A
----
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
-
V
V
Q
E
M
G
K
F
T
K
I
T
S
Q
L
I
V
P
D
S
F
E
K
N
K
Q
I
N
A
-----
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
R
R
K
L
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
D
Q
Q
G
L
G
D
Q
C
I
R
V
K
R
F
--
L
----
P
--
K
------
D
--
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
------
D
A
I
K
Q
L
Y
M
D
C
K
N
E
A
D
-
K
F
D
V
--
L
T
E
L
Y
G
-
V
M
T
I
G
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
L
A
N
GQAD
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
S
-
F
N
I
L
S
A
----
I
Q
K
Y
F
GD
I
E
M
T
R
---
V
P
T
D
D
W
D
E
V
E
K
I
V
K
K
V
L
K
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
84.61
33%
-105
- C3 -
3PEW
10
DBP5_YEAST
A:
[6-383]
-
S
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
N
P
----------------------
E
D
A
S
P
Q
A
----
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
-
V
V
Q
E
M
G
K
F
T
K
I
T
S
Q
L
I
V
P
D
S
F
E
K
N
K
Q
I
N
A
-----
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
R
R
K
L
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
D
Q
Q
G
L
G
D
Q
C
I
R
V
K
R
F
--
L
----
P
--
K
------
D
--
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
T
N
E
V
N
V
D
A
I
K
Q
L
Y
M
D
C
K
N
E
A
D
-
K
F
D
V
--
L
T
E
L
Y
G
-
V
M
T
I
G
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
L
A
N
GQAD
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
S
-
F
N
I
L
S
A
----
I
Q
K
Y
F
GD
I
E
M
T
R
---
V
P
T
D
D
W
D
E
V
E
K
I
V
K
K
V
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
84.49
31%
-123
- C3 -
2VSX
1
IF4A_YEAST
B:
[24-385]
--
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
------------------------
D
T
S
V
K
A
P
Q
--
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
-
V
V
M
A
L
A
F
H
M
D
I
K
V
H
A
C
I
-
G
----------
L
-
R
D
A
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
Q
R
R
R
F
R
T
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
S
S
-
G
F
K
E
Q
I
Y
Q
I
F
T
L
--
L
----
P
--
P
------
T
--
T
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
E
L
T
L
E
G
I
K
Q
F
Y
V
N
V
E
-
E
E
E
Y
K
Y
E
C
--
L
T
D
L
Y
D
-
S
I
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
N
K
E
------
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
-
N
E
D
-
V
G
A
M
R
E
----
L
E
K
------
F
Y
S
---
T
Q
I
E
E
L
P
S
D
I
A
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
84.29
31%
-123
- C3 -
2VSX
1
IF4A_YEAST
A:
[24-385]
--
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
------------------------
D
T
S
V
K
A
P
Q
--
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
-
V
V
M
A
L
A
F
H
M
D
I
K
V
H
A
C
I
-
G
----------
L
-
R
D
A
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
Q
R
R
R
F
R
T
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
S
S
-
G
F
K
E
Q
I
Y
Q
I
F
T
L
--
L
----
P
--
P
------
T
--
T
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
E
L
T
L
E
G
I
K
Q
F
Y
V
N
V
E
-
E
E
E
Y
K
Y
E
C
--
L
T
D
L
Y
D
-
S
I
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
N
K
E
------
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
-
N
E
D
-
V
G
A
M
R
E
----
L
E
K
------
F
Y
S
---
T
Q
I
E
E
L
P
S
D
I
A
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
84.27
34%
-104
- C3 -
2XB2
4
IF4A3_HUMAN
A:
[39-402]
-
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
-----------
D
I
--------
Q
-----
V
R
E
T
Q
--
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
-
G
L
L
A
L
G
D
Y
M
N
V
Q
C
H
A
C
I
-
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
K
-
G
F
K
E
Q
I
Y
D
V
Y
R
Y
--
L
----
P
--
P
------
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
-
R
E
E
W
K
F
D
T
--
L
C
D
L
Y
D
-
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
------
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
-
N
D
D
-
I
R
I
L
R
D
----
I
E
Q
------
Y
Y
S
---
T
Q
I
D
E
M
P
M
N
V
A
D
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
84.14
31%
-123
- C3 -
2VSO
1
IF4A_YEAST
A:
[24-385]
--
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
------------------------
D
T
S
V
K
A
P
Q
--
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
-
V
V
M
A
L
A
F
H
M
D
I
K
V
H
A
C
I
-
G
----------
L
-
R
D
A
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
Q
R
R
R
F
R
T
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
S
S
-
G
F
K
E
Q
I
Y
Q
I
F
T
L
--
L
----
P
--
P
------
T
--
T
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
E
L
T
L
E
G
I
K
Q
F
Y
V
N
V
E
-
E
E
E
Y
K
Y
E
C
--
L
T
D
L
Y
D
-
S
I
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
N
K
E
------
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
-
N
E
D
-
V
G
A
M
R
E
----
L
E
K
------
F
Y
S
---
T
Q
I
E
E
L
P
S
D
I
A
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
67.47
44%
-124
- C3 -
3NBF
4
?
C:
[1-205]
M
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
A
P
S
-------------------
Q
-
E
R
G
-
R
K
P
R
--
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
-
E
L
T
A
V
A
P
H
L
--
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
L
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
-
G
F
E
E
E
V
E
A
L
L
S
A
--
T
----
P
--
P
------
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
67.45
44%
-119
- C3 -
3NBF
2
?
A:
[1-205]
M
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
A
P
S
-------------------
Q
-
E
R
G
-
R
K
P
R
--
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
-
E
L
T
A
V
A
P
H
L
--
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
L
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
-
G
F
E
E
E
V
E
A
L
L
S
A
--
T
----
P
--
P
------
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
67.43
44%
-127
- C3 -
3NBF
2
?
D:
[1-205]
M
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
----
G
K
T
L
A
F
A
L
P
I
A
E
R
L
A
P
S
-------------------
Q
-
E
R
G
-
R
K
P
R
--
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
-
E
L
T
A
V
A
P
H
L
--
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
L
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
-
G
F
E
E
E
V
E
A
L
L
S
A
--
T
----
P
--
P
------
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
67.07
44%
-114
- C3 -
3NBF
2
?
B:
[2-205]
-
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
A
P
S
-------------------
Q
-
E
R
G
-
R
K
P
R
--
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
-
E
L
T
A
V
A
P
H
L
--
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
L
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
-
G
F
E
E
E
V
E
A
L
L
S
A
--
T
----
P
--
P
------
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
66.97
45%
-120
- C3 -
2GXS
4
?
B:
[1-205]
M
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
A
P
S
-------------------
Q
-
E
R
G
-
R
K
P
R
--
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
-
E
L
T
A
V
A
P
H
L
--
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
L
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
-
G
F
E
E
E
V
E
A
L
L
S
A
--
T
----
P
--
P
------
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
59.94
35%
-110
- C3 -
1VEC
1
DDX6_HUMAN
B:
[5-205]
--
F
E
D
Y
C
L
K
R
E
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
S
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
R
L
---------------------
D
L
-
K
K
D
N
I
Q
A
M
--
V
I
V
--
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
Q
V
S
K
H
M
G
G
A
K
V
M
A
T
T
-
G
G
T
N
L
R
D
D
I
M
R
L
D
D
T
V
H
V
V
I
A
T
P
G
R
I
L
D
L
I
K
K
G
V
A
K
V
D
H
V
Q
M
I
V
L
D
E
A
D
K
L
L
S
Q
-
D
F
V
Q
I
M
E
D
I
I
L
T
--
L
----
P
--
K
------
N
--
R
Q
I
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
E
K
P
Y
E
I
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------