@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0430: (2016-01-04 )
MVASKEPIMSQSERRFSFEFFPAKTEAGHEKLLATARNLAGYKPDFFSCTYGAGGSTRDRTLSTVLQLDGEVKVPTAPHLSCVGDSKAELRELLGRYREAGIRRIVALRGDLPSGMGMASGELRYANELVDFIRTETGDHFHIEVAAYPEVHPQARSFEDDLANFVRKVKAGASSAITQYFFNADAYFYFVERVAKLGVDIPVVPGIMPITNYSKLARFSDACGAELPRWIRKQLEAYGDDSRSIQAFGEQVISEMCERLLEGGAPGLHFYTLNQADPSLAIWKNLQLPR
Atome Classification :
(33 SA)
.........10........20........30........40--........50........60........70........80........90........100.......110......-.--120---.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......-250.......260.......270.......280.......290
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVASKEPIMSQSER
R
F
S
F
E
FFPAKTEA
G
H
E
K
L
L
A
T
A
R
N
LAG--YKP
D
F
F
S
C
TYGAGGSTR
D
R
T
L
S
T
V
L
QLDGEVKVPTAPH
L
S
CVGD
S
K
A
E
L
R
E
L
L
G
R
Y
R
E
A
G
I
R
R
I
V
A
LRGDLPSGMGM-A--SG
E
---
L
R
Y
A
N
E
L
V
D
F
I
RTETG
D
H
F
H
I
E
V
A
AYPEVHPQAR
S
F
E
D
D
L
A
N
F
V
R
K
V
KAG
A
S
S
A
I
T
Q
Y
FFNA
D
A
Y
F
Y
F
V
E
R
V
A
KLGVDIPVVPGIMPIT
N
Y
S
K
L
A
R
F
S
D
A
CG
A
E
L
P
R
W
I
R
K
Q
L
E
AYGDD
S
R
S
I
Q
A
F
G
-
E
Q
V
I
S
E
M
C
E
R
L
L
EGGAPG
L
H
F
Y
T
LNQADPS
L
A
I
W
KNLQLPR-
6
PsiBlast_PDB
96.48
40%
-113
- C8 -
1ZRQ
4
METF_ECOLI
A:
[20-290]
----------
Q
G
Q
I
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
G
A
-----
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
---------
E
------
M
Y
A
S
D
L
V
T
L
L
K
-
E
V
A
D
-
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-
31
PsiBlast_CBE
95.31
40%
-111
- C8 -
1ZPT
3
METF_ECOLI
C:
[22-290]
------------
Q
I
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
-----------------
M
Y
A
S
D
L
V
T
L
L
K
-
E
V
A
D
-
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-
5
PsiBlast_PDB
94.93
40%
-119
- C8 -
1ZPT
4
METF_ECOLI
A:
[20-290]
----------
Q
G
Q
I
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
---------
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
-------------------
M
Y
A
S
D
L
V
T
L
L
K
-
E
V
A
D
-
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-
43
PsiBlast_CBE
94.88
39%
-116
- C8 -
3FST
3
METF_ECOLI
E:
[20-290]
----------
Q
G
Q
I
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
---------
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
-----------
E
------
M
Y
A
S
D
L
V
T
L
L
K
-
E
V
A
D
-
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
L
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-
11
PsiBlast_PDB
94.87
39%
-109
- C8 -
3FST
1
METF_ECOLI
A:
[20-290]
----------
Q
G
Q
I
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
---------
E
------
M
Y
A
S
D
L
V
T
L
L
K
-
E
V
A
D
-
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
L
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-
57
HHSearch
94.86
41%
-104
- C8 -
3APT
1
?
A:
[10-291]
----------
R
R
G
P
L
F
S
F
E
F
F
P
P
K
D
P
E
G
E
E
A
L
F
R
T
L
E
E
L
K
A
--
F
R
P
A
F
V
S
I
T
Y
G
A
M
G
S
T
R
E
R
S
V
A
W
A
Q
R
I
Q
S
L
-
G
L
N
P
L
A
H
L
T
V
A
G
Q
S
R
K
E
V
A
E
V
L
H
R
F
V
E
S
G
V
E
N
L
L
A
L
R
G
D
P
P
R
G
E
R
V
F
R
P
H
P
E
G
---
F
R
Y
A
A
E
L
V
A
L
I
R
E
R
Y
G
D
R
V
S
V
G
G
A
A
Y
P
E
G
H
P
E
S
E
S
L
E
A
D
L
R
H
F
K
A
K
V
E
A
G
L
D
F
A
I
T
Q
L
F
F
N
N
A
H
Y
F
G
F
L
E
R
A
R
R
A
G
I
G
I
P
I
L
P
G
I
M
P
V
T
S
Y
R
Q
L
R
R
F
T
E
V
C
G
A
S
I
P
G
P
L
L
A
K
L
E
R
H
Q
D
D
P
K
A
V
L
E
I
G
-
V
E
H
A
V
R
Q
V
A
E
L
L
E
A
G
V
E
G
V
H
F
Y
T
L
N
K
S
P
A
T
R
M
V
L
E
R
L
G
L
R
P
-
30
PsiBlast_CBE
94.85
40%
-109
- C8 -
1ZRQ
3
METF_ECOLI
B:
[20-290]
----------
Q
G
Q
I
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
--------
E
------
M
Y
A
S
D
L
V
T
L
L
K
-
E
V
A
D
-
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-
4
PsiBlast_PDB
94.80
40%
-111
- C8 -
1ZP3
4
METF_ECOLI
A:
[20-290]
----------
Q
G
Q
I
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
----------------
M
Y
A
S
D
L
V
T
L
L
K
-
E
V
A
D
-
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-
34
PsiBlast_CBE
94.66
40%
-111
- C8 -
1ZP3
3
METF_ECOLI
B:
[20-290]
----------
Q
G
Q
I
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
G
--
K
-
P
--
E
------
M
Y
A
S
D
L
V
T
L
L
K
-
E
V
A
D
-
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-
33
PsiBlast_CBE
94.65
40%
-111
- C8 -
1ZP3
3
METF_ECOLI
C:
[21-290]
-----------
G
Q
I
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
----------
E
------
M
Y
A
S
D
L
V
T
L
L
K
-
E
V
A
D
-
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-
7
PsiBlast_PDB
94.40
39%
-115
- C8 -
1ZP4
3
METF_ECOLI
A:
[20-290]
----------
Q
G
Q
I
N
V
S
F
Q
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
G
-------
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
G
----
P
--
E
------
M
Y
A
S
D
L
V
T
L
L
K
-
E
V
A
D
-
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-
39
PsiBlast_CBE
94.38
39%
-111
- C8 -
2FMN
2
METF_ECOLI
C:
[21-290]
-----------
G
Q
I
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
--------
E
------
M
Y
A
S
D
L
V
T
L
L
K
-
E
V
A
D
-
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
V
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-
45
PsiBlast_CBE
94.36
39%
-119
- C8 -
3FSU
3
METF_ECOLI
E:
[20-290]
----------
Q
G
Q
I
N
V
S
F
Q
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
---------
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
--------
E
------
M
Y
A
S
D
L
V
T
L
L
K
-
E
V
A
D
-
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
L
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-
32
PsiBlast_CBE
94.36
40%
-110
- C8 -
1ZPT
3
METF_ECOLI
B:
[20-290]
----------
Q
G
Q
I
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
----------
E
------
M
Y
A
S
D
L
V
T
L
L
K
-
E
V
A
D
-
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-
29
PsiBlast_CBE
94.09
40%
-108
- C8 -
1ZRQ
3
METF_ECOLI
C:
[22-290]
------------
Q
I
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
--------
E
------
M
Y
A
S
D
L
V
T
L
L
K
-
E
V
A
D
-
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-
36
PsiBlast_CBE
94.05
39%
-114
- C8 -
1ZP4
2
METF_ECOLI
B:
[20-290]
----------
Q
G
Q
I
N
V
S
F
Q
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
----------
E
------
M
Y
A
S
D
L
V
T
L
L
K
-
E
V
A
D
-
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-
23
PsiBlast_CBE
94.02
42%
-102
- C8 -
3APY
2
?
F:
[15-289]
---------------
F
S
F
E
F
F
P
P
K
D
P
E
G
E
E
A
L
F
R
T
L
E
E
L
K
A
--
F
R
P
A
F
V
S
I
T
Y
G
A
M
G
S
T
R
E
R
S
V
A
W
A
Q
R
I
Q
S
L
G
L
N
P
L
A
-
H
L
T
V
A
G
Q
S
R
K
E
V
A
E
V
L
H
R
F
V
E
S
G
V
E
N
L
L
A
L
R
G
D
P
P
R
G
E
R
V
-
F
--
R
P
H
PEG
F
R
Y
A
A
E
L
V
A
L
I
R
E
R
Y
G
D
R
V
S
V
G
G
A
A
Y
P
E
G
H
P
E
S
E
S
L
E
A
D
L
R
H
F
K
A
K
V
E
A
G
L
D
F
A
I
T
Q
L
F
F
N
N
A
H
Y
F
G
F
L
E
R
A
R
R
A
G
I
G
I
P
I
L
P
G
I
M
P
V
T
S
Y
R
Q
L
R
R
F
T
E
V
C
G
A
S
I
P
G
P
L
L
A
K
L
E
R
H
Q
D
D
P
K
A
V
L
E
I
G
V
E
H
A
V
R
Q
V
A
E
-
L
L
E
A
G
V
E
G
V
H
F
Y
T
L
N
K
S
P
A
T
R
M
V
L
E
R
L
G
L
R
P
-
38
PsiBlast_CBE
93.79
39%
-112
- C8 -
2FMO
4
METF_ECOLI
B:
[20-290]
----------
Q
G
Q
I
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
--------
E
------
M
Y
A
S
D
L
V
T
L
L
K
-
E
V
A
D
-
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
V
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-
48
Fugue
93.72
39%
-106
- C8 -
1B5T
2
METF_ECOLI
A:
[1-275]
-----------
G
Q
I
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
G
----
S
--
G
K
P
---
E
M
Y
A
S
D
L
V
T
L
L
K
E
V
--
A
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
A
35
PsiBlast_CBE
93.67
39%
-109
- C8 -
1ZP4
3
METF_ECOLI
C:
[22-290]
------------
Q
I
N
V
S
F
Q
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
---------
E
------
M
Y
A
S
D
L
V
T
L
L
K
-
E
V
A
D
-
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-
37
PsiBlast_CBE
93.66
39%
-113
- C8 -
2FMO
3
METF_ECOLI
C:
[22-290]
------------
Q
I
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
G
A
N
S
-
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
----------
E
------
M
Y
A
S
D
L
V
T
L
L
K
-
E
V
A
D
-
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
V
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-
12
PsiBlast_PDB
93.52
39%
-111
- C8 -
3FSU
2
METF_ECOLI
A:
[20-290]
----------
Q
G
Q
I
N
V
S
F
Q
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
----------
E
------
M
Y
A
S
D
L
V
T
L
L
K
-
E
V
A
D
-
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
L
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-
44
PsiBlast_CBE
93.43
39%
-109
- C8 -
3FST
2
METF_ECOLI
C:
[22-290]
------------
Q
I
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
-----------
E
------
M
Y
A
S
D
L
V
T
L
L
K
-
E
V
A
D
-
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
L
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-
40
PsiBlast_CBE
93.33
39%
-111
- C8 -
2FMN
2
METF_ECOLI
B:
[20-290]
----------
Q
G
Q
I
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
--------
E
------
M
Y
A
S
D
L
V
T
L
L
K
-
E
V
A
D
-
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
V
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-
9
PsiBlast_PDB
93.26
39%
-114
- C8 -
2FMO
4
METF_ECOLI
A:
[22-290]
------------
Q
I
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
G
A
-----
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
----------
E
------
M
Y
A
S
D
L
V
T
L
L
K
-
E
V
A
D
-
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
V
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-
1
PsiBlast_PDB
93.20
42%
-102
- C8 -
1V93
7
?
A:
[15-289]
---------------
F
S
F
E
F
F
P
P
K
D
P
E
G
E
E
A
L
F
R
T
L
E
E
L
K
A
--
F
R
P
A
F
V
S
I
T
Y
G
A
M
G
S
T
R
E
R
S
V
A
W
A
Q
R
I
Q
S
L
G
L
N
P
L
A
-
H
L
T
V
A
G
Q
S
R
K
E
V
A
E
V
L
H
R
F
V
E
S
G
V
E
N
L
L
A
L
R
G
D
P
P
R
G
E
R
V
-
F
--
R
P
H
PEG
F
R
Y
A
A
E
L
V
A
L
I
R
E
R
Y
G
D
R
V
S
V
G
G
A
A
Y
P
E
G
H
P
E
S
E
S
L
E
A
D
L
R
H
F
K
A
K
V
E
A
G
L
D
F
A
I
T
Q
L
F
F
N
N
A
H
Y
F
G
F
L
E
R
A
R
R
A
G
I
G
I
P
I
L
P
G
I
M
P
V
T
S
Y
R
Q
L
R
R
F
T
E
V
C
G
A
S
I
P
G
P
L
L
A
K
L
E
R
H
Q
D
D
P
K
A
V
L
E
I
G
V
E
H
A
V
R
Q
V
A
E
-
L
L
E
A
G
V
E
G
V
H
F
Y
T
L
N
K
S
P
A
T
R
M
V
L
E
R
L
G
L
R
P
-
10
PsiBlast_PDB
92.93
40%
-108
- C8 -
1B5T
2
METF_ECOLI
A:
[6-270]
----------------
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
G
S
G
K
-
P
--
E
------
M
Y
A
S
D
L
V
T
L
L
K
-
E
V
A
D
-
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-
2
PsiBlast_PDB
92.88
42%
-102
- C8 -
3APT
1
?
A:
[15-289]
---------------
F
S
F
E
F
F
P
P
K
D
P
E
G
E
E
A
L
F
R
T
L
E
E
L
K
A
--
F
R
P
A
F
V
S
I
T
Y
G
A
M
G
S
T
R
E
R
S
V
A
W
A
Q
R
I
Q
S
L
G
L
N
P
L
A
-
H
L
T
V
A
G
Q
S
R
K
E
V
A
E
V
L
H
R
F
V
E
S
G
V
E
N
L
L
A
L
R
G
D
P
P
R
G
E
R
V
-
F
--
R
P
H
PEG
F
R
Y
A
A
E
L
V
A
L
I
R
E
R
Y
G
D
R
V
S
V
G
G
A
A
Y
P
E
G
H
P
E
S
E
S
L
E
A
D
L
R
H
F
K
A
K
V
E
A
G
L
D
F
A
I
T
Q
L
F
F
N
N
A
H
Y
F
G
F
L
E
R
A
R
R
A
G
I
G
I
P
I
L
P
G
I
M
P
V
T
S
Y
R
Q
L
R
R
F
T
E
V
C
G
A
S
I
P
G
P
L
L
A
K
L
E
R
H
Q
D
D
P
K
A
V
L
E
I
G
V
E
H
A
V
R
Q
V
A
E
-
L
L
E
A
G
V
E
G
V
H
F
Y
T
L
N
K
S
P
A
T
R
M
V
L
E
R
L
G
L
R
P
-
46
PsiBlast_CBE
92.87
39%
-111
- C8 -
3FSU
2
METF_ECOLI
C:
[22-290]
------------
Q
I
N
V
S
F
Q
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
----------
E
------
M
Y
A
S
D
L
V
T
L
L
K
-
E
V
A
D
-
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
L
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-
8
PsiBlast_PDB
92.68
39%
-109
- C8 -
2FMN
2
METF_ECOLI
A:
[20-290]
----------
Q
G
Q
I
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
--------
E
------
M
Y
A
S
D
L
V
T
L
L
K
-
E
V
A
D
-
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
V
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-
42
PsiBlast_CBE
92.29
40%
-108
- C8 -
1B5T
2
METF_ECOLI
B:
[6-270]
----------------
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
G
S
G
K
-
P
--
E
------
M
Y
A
S
D
L
V
T
L
L
K
-
E
V
A
D
-
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-
41
PsiBlast_CBE
92.29
40%
-113
- C8 -
1B5T
2
METF_ECOLI
C:
[6-270]
----------------
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
--
L
K
P
K
F
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
----------------
Y
A
S
D
L
V
T
L
L
K
-
E
V
A
D
-
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-
58
HHSearch
89.68
36%
-97
* C8 *
3FST
1
METF_ECOLI
A:
[17-294]
-------
A
E
V
Q
G
Q
I
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
--
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
---------------
E
M
Y
A
S
D
L
V
T
L
L
K
E
V
--
A
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
L
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
-
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-