@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0432: (2016-01-04 )
MSAVMTPAGFTDYKVADITLAAWGRRELIIAESEMPALMGLRRKYAGQQPLKGAKILGCIHMTIQTGVLIETLVALGAEVRWSSCNIFSTQDQAAAAIAAAGIPVFAWKGETEEEYEWCIEQTILKDGQPWDANMVLDDGGDLTEILHKKYPQMLERIHGITEETTTGVHRLLDMLKNGTLKVPAINVNDSVTKSKNDNKYGCRHSLNDAIKRGTDHLLSGKQALVIGYGDVGKGSSQSLRQEGMIVKVAEVDPICAMQACMDGFEVVSPYKNGINDGTEASIDAALLGKIDLIVTTTGNVNVCDANMLKALKKRAVVCNIGHFDNEIDTAFMRKNWAWEEVKPQVHKIHRTGKDGFDAHNDDYLILLAEGRLVNLGNATGHPSRIMDGSFANQVLAQIHLFEQKYADLPAAEKAKRLSVEVLPKKLDEEVALEMVKGFGGVVTQLTPKQAEYIGVSVEGPFKPDTYRY
Atome Classification :
(35 SA)
.........10........20........30........40........50........60........70........80........90........100--------........110.......120..-.....130.......140..-----------------------------------....-----------------------------------------.-------------------------------------150---------------------------------------.-------------------------------------........160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330...-.--...340.--....-.--..350-.........360-.......370.......380.......390.......400..--..-...410.......420.......430.......440.......450.......460.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSAVMTPAGFTD
Y
K
V
A
D
I
T
L
A
AWG
R
R
E
L
I
I
AESE
M
P
A
L
M
G
L
R
R
K
YAGQQPLKG
A
K
I
L
G
C
I
H
M
T
IQ
T
G
V
L
I
E
T
L
V
ALGA
E
V
R
WSS
C
N
I
FST
Q
D
Q
A
A
A
A
I
AAA---------G
I
P
V
F
A
WKGE
T
E
E
E
Y
E
W
C
I
E
Q
T
I
-LKDGQPWDA
N
M
V
LDDGG
D
L
T
-----------------------------------
E
I
L
H
-----------------------------------------
K
-------------------------------------
K
-----------------------------------------
Y
-------------------------------------
P
Q
M
L
E
R
I
HGITEE
T
T
T
G
V
H
R
L
L
D
M
LKNG
T
L
K
V
P
A
I
NVNDSVTKSKNDNKYGC
R
H
S
L
N
D
A
I
K
RG
T
D
H
LLSGK
Q
A
L
V
I
G
YGDVGKG
S
S
Q
S
L
R
QE
G
M
I
V
K
V
AEVD
P
I
C
A
M
Q
A
C
MD
G
F
E
V
V
S
P
Y
KNGINDGTE
A
S
I
D
A
A
L
LGK
I
D
L
I
V
TTTGNVNVC
D
A
N
M
L
K
A
L
K
KR
A
V
V
C
NIGHFDN
E
I
D
T
A
F
M
RK-N--W
A
W
E
-
E
V--
K
P
Q
V
-
H
--
K
I
H---RTGKDGFDAHND-
D
Y
L
I
L
LAE
G
R
L
V
NLGNATGHPSRIM
D
G
S
F
A
N
Q
V
L
A
Q
I
H
L
F
E
Q
--
K
Y-ADLP
A
A
E
K
A
K
R
L
S
V
E
V
L
P
K
KL
D
E
E
V
A
L
E
M
V
K
GF
G
G
V
V
TQLTPKQA
E
Y
I
G
V
S
VEGPFKPDTYRY
10
PsiBlast_PDB
93.58
57%
-87
- C3 -
1KY5
3
SAHH_RAT
A:
[6-431]
------------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
M
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
A
L
G
A
E
V
R
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
---------
G
I
P
V
F
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
H
F
K
D
G
P
---
L
N
M
I
L
D
D
G
G
D
L
T
-----------------------------------
N
L
I
H
-----------------------------------------
T
-------------------------------------
K
-----------------------------------------
H
-------------------------------------
P
Q
L
L
S
G
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
E
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
-------------
T
T
M
D
E
A
-
C
K
E
G
N
I
F
V
T
T
T
G
C
V
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
-
N
---
A
V
E
-
K
V
N
I
K
P
Q
V
--------------
D
R
Y
L
L
K
N
G
-
H
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
PD
K
Y
-
P
----------
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
P
I
N
G
P
F
K
P
D
H
Y
R
Y
50
PsiBlast_CBE
93.29
57%
-86
- C3 -
1KY5
3
SAHH_RAT
D:
[6-431]
------------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
M
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
A
L
G
A
E
V
R
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
---------
G
I
P
V
F
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
H
F
K
D
G
P
---
L
N
M
I
L
D
D
G
G
D
L
T
-----------------------------------
N
L
I
H
-----------------------------------------
T
-------------------------------------
K
-----------------------------------------
H
-------------------------------------
P
Q
L
L
S
G
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
E
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
-------------
T
T
M
D
E
A
-
C
K
E
G
N
I
F
V
T
T
T
G
C
V
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
-
N
---
A
V
E
-
K
V
NI
K
P
Q
V
--------------
D
R
Y
L
L
K
N
G
-
H
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
PD
K
Y
-
P
----------
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
P
I
N
G
P
F
K
P
D
H
Y
R
Y
52
PsiBlast_CBE
93.27
57%
-86
- C3 -
1KY5
3
SAHH_RAT
B:
[6-431]
------------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
M
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
A
L
G
A
E
V
R
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
---------
G
I
P
V
F
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
H
F
K
D
G
P
---
L
N
M
I
L
D
D
G
G
D
L
T
-----------------------------------
N
L
I
H
-----------------------------------------
T
-------------------------------------
K
-----------------------------------------
H
-------------------------------------
P
Q
L
L
S
G
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
E
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
-------------
T
T
M
D
E
A
-
C
K
E
G
N
I
F
V
T
T
T
G
C
V
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
-
N
---
A
V
E
-
K
V
NI
K
P
Q
V
--------------
D
R
Y
L
L
K
N
G
-
H
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
PD
K
Y
-
P
----------
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
P
I
N
G
P
F
K
P
D
H
Y
R
Y
111
HHSearch
93.23
58%
-84
- C3 -
3D64
2
SAHH_BURP1
A:
[33-494]
----------
Q
D
Y
V
V
A
D
I
A
L
A
G
W
G
R
K
E
L
N
I
A
E
T
E
M
P
G
L
V
Q
I
R
D
E
Y
K
A
Q
Q
P
L
K
G
A
R
I
A
G
S
L
H
M
T
I
Q
T
G
V
L
I
E
T
L
K
A
L
G
A
D
V
R
W
A
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
V
E
A
---------
G
T
P
V
F
A
F
K
G
E
S
L
D
E
Y
W
E
F
S
H
R
I
F
-
E
W
P
-
N
G
E
F
A
N
M
I
L
D
D
G
G
D
A
T
-----------------------------------
L
L
L
I
-----------------------------------------
L
G
S
K
A
E
K
DRSVIARPTN
E
E
E
V
A
L
F
K
S
I
E
R
H
L
E
I
DGS--
W
-----------------------------------------
Y
-------------------------------------
S
K
R
L
A
H
I
K
G
V
T
E
E
T
T
T
G
V
H
R
L
Y
Q
M
E
K
D
G
R
L
P
F
P
A
F
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
V
D
G
I
K
R
A
T
D
V
M
I
A
G
K
I
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
S
L
R
G
L
G
A
T
V
W
V
T
E
I
D
P
I
C
A
L
Q
A
A
M
E
G
Y
R
V
V
T
M
E
------------
Y
--
A
A
D
K
A
D
I
F
V
T
A
T
G
N
Y
H
V
I
N
H
D
H
M
K
A
M
R
H
N
A
I
V
C
N
I
G
H
F
D
S
E
I
D
V
A
S
T
R
Q
-
Y
--
Q
W
-
E
-
N
I
--
K
P
Q
V
-
D
--
H
I
I
---
F
--------
P
D
G
-
K
R
V
I
L
L
A
E
G
R
L
V
N
L
G
C
A
T
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
T
L
A
Q
I
E
L
F
T
R
--
G
G
--
E
Y
-------
A
N
K
V
Y
V
L
P
K
H
L
D
E
K
V
A
R
L
H
L
A
R
I
G
A
Q
L
S
E
L
S
D
D
Q
A
A
Y
I
G
V
S
K
A
G
P
F
K
P
D
H
Y
R
Y
41
PsiBlast_CBE
93.20
57%
-88
- C3 -
1B3R
2
SAHH_RAT
D:
[6-431]
------------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
M
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
A
L
G
A
E
V
R
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
---------
G
I
P
V
F
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
H
F
K
D
G
P
---
L
N
M
I
L
D
D
G
G
D
L
T
-----------------------------------
N
L
I
H
-----------------------------------------
T
-------------------------------------
K
-----------------------------------------
H
-------------------------------------
P
Q
L
L
S
G
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
-------------
T
T
M
D
E
A
-
C
K
E
G
N
I
F
V
T
T
T
G
C
V
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
-
N
---
A
V
E
-
K
V
NI
K
P
Q
V
--------------
D
R
Y
L
L
K
N
G
-
H
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
PD
K
Y
-
P
----------
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
P
I
N
G
P
F
K
P
D
H
Y
R
Y
49
PsiBlast_CBE
92.81
56%
-80
- C3 -
3NJ4
3
SAHH_HUMAN
B:
[10-435]
------------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
R
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
T
L
G
A
E
V
Q
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
---------
G
I
P
V
Y
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
Y
F
K
D
G
P
---
L
N
M
I
L
D
D
G
G
D
L
T
-----------------------------------
N
L
I
H
-----------------------------------------
T
-------------------------------------
K
-----------------------------------------
Y
-------------------------------------
P
Q
L
L
P
G
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
-----
M
D
E
A
C
Q
E
G
---------
N
I
F
V
T
T
T
G
C
I
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
-
N
---
A
V
E
-
K
V
N
I
K
P
Q
V
--------------
D
R
Y
R
L
K
N
G
-
R
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
P
D
K
Y
-
P
----------
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
S
C
D
G
P
F
K
P
D
H
Y
R
Y
67
PsiBlast_CBE
92.76
48%
-77
- C3 -
3DHY
3
SAHH_MYCTU
C:
[20-495]
-----------
D
F
K
I
A
D
L
S
L
A
D
F
G
R
K
E
L
R
I
A
E
H
E
M
P
G
L
M
S
L
R
R
E
Y
A
E
V
Q
P
L
K
G
A
R
I
S
G
S
L
H
M
T
V
Q
T
A
V
L
I
E
T
L
T
A
L
G
A
E
V
R
W
A
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
V
V
V
G
PHGTPDEPK
G
V
P
V
F
A
W
K
G
E
T
L
E
E
Y
W
W
A
A
E
Q
M
L
-
T
W
P
D
P
D
K
P
A
N
M
I
L
D
D
G
G
D
A
T
-----------------------------------
M
L
V
L
-----------------------------------------
R
GMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKD
K
-----------------------------------------
W
-------------------------------------
T
K
I
A
E
S
V
K
G
V
T
E
E
T
T
T
G
V
L
R
L
Y
Q
F
A
A
A
G
D
L
A
F
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
K
Y
G
T
R
H
S
L
I
D
G
I
N
R
G
T
D
A
L
I
G
G
K
K
V
L
I
C
G
Y
G
D
V
G
K
G
C
A
E
A
M
K
G
Q
G
A
R
V
S
V
T
E
I
D
P
I
N
A
L
Q
A
M
M
E
G
F
D
V
V
T
---------
V
E
E
A
I
-----
G
D
A
D
I
V
V
T
A
T
G
N
K
D
I
I
M
L
E
H
I
K
A
M
K
D
H
A
I
L
G
N
I
G
H
F
D
N
E
I
D
M
A
G
L
E
R
-
S
--
G
A
T
R
V
N
V
--
K
P
Q
V
-
D
LW
T
F
G
---
D
T
G
R
S
----------
I
I
V
L
S
E
G
R
L
L
N
L
G
N
A
T
G
H
P
S
F
V
M
S
N
S
F
A
N
Q
T
I
A
Q
I
E
L
W
T
K
ND
E
Y
-
D
N
----------
E
V
Y
R
L
P
K
H
L
D
E
K
V
A
R
I
H
V
E
A
L
G
G
H
L
T
K
L
T
K
E
Q
A
E
Y
L
G
V
D
V
E
G
P
Y
K
P
D
H
Y
R
Y
37
PsiBlast_CBE
92.72
57%
-81
- C3 -
1K0U
3
SAHH_RAT
E:
[6-431]
------------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
M
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
A
L
G
A
E
V
R
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
---------
G
I
P
V
F
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
H
F
K
D
G
P
---
L
N
M
I
L
D
D
G
G
D
L
T
-----------------------------------
N
L
I
H
-----------------------------------------
T
-------------------------------------
K
-----------------------------------------
H
-------------------------------------
P
Q
L
L
S
G
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
-------------
T
T
M
D
E
A
-
C
K
E
G
N
I
F
V
T
T
T
G
C
V
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
-
N
---
A
V
E
-
K
V
NI
K
P
Q
V
--------------
D
R
Y
L
L
K
N
G
-
H
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
PD
K
Y
-
P
----------
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
P
I
N
G
P
F
K
P
D
H
Y
R
Y
116
HHSearch
92.67
49%
-92
- C3 -
3GVP
2
SAHH3_HUMAN
A:
[6-435]
----
K
N
S
K
G
S
S
D
F
C
V
K
N
I
K
Q
A
E
F
G
R
R
E
I
E
I
A
E
Q
E
M
P
A
L
M
A
L
R
K
R
A
Q
G
E
K
P
L
A
G
A
K
I
V
G
C
T
H
I
T
A
Q
T
A
V
L
M
E
T
L
G
A
L
G
A
Q
C
R
W
A
A
C
N
I
Y
S
T
L
N
E
V
A
A
A
L
A
E
S
---------
G
F
P
V
F
A
W
K
G
E
S
E
D
D
F
W
W
C
I
D
R
C
V
-
N
V
--
E
G
W
Q
P
N
M
I
L
D
D
G
G
D
L
T
-----------------------------------
H
W
I
Y
-----------------------------------------
K
-------------------------------------
K
-----------------------------------------
Y
-------------------------------------
P
N
M
F
K
K
I
K
G
I
V
E
E
S
V
T
G
V
H
R
L
Y
Q
L
--
A
G
K
L
C
V
P
A
M
N
V
N
D
S
V
T
K
Q
K
F
D
N
L
Y
C
C
R
E
S
I
L
D
G
L
K
R
T
T
D
M
M
F
G
G
K
Q
V
V
V
C
G
Y
G
E
V
G
K
G
C
C
A
A
L
K
A
M
G
S
I
V
Y
V
T
E
I
D
P
I
C
A
L
Q
A
C
M
D
G
F
R
L
V
K
L
N
------------
E
--
V
I
R
Q
V
D
I
V
I
T
C
T
G
N
K
N
V
V
T
R
E
H
L
D
R
M
K
N
S
C
I
V
C
N
M
G
H
S
N
T
E
I
D
V
A
S
L
R
T
P
E
--
L
T
W
E
-
R
V
--
R
S
Q
V
-
D
--
H
V
I
---
W
--------
P
D
G
-
K
R
I
V
L
L
A
E
G
R
L
L
N
L
S
C
S
-
T
V
P
T
F
V
L
S
I
T
A
T
T
Q
A
L
A
L
I
E
L
Y
N
A
--
P
E
-
G
R
Y
-------
K
Q
D
V
Y
L
L
P
K
K
M
D
E
Y
V
A
S
L
H
L
P
T
F
D
A
H
L
T
E
L
T
D
E
Q
A
K
Y
L
G
L
N
K
N
G
P
F
K
P
N
----
59
PsiBlast_CBE
92.67
56%
-83
- C3 -
4PGF
2
SAHH_HUMAN
B:
[7-432]
------------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
R
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
T
L
G
A
E
V
Q
W
S
S
C
N
I
F
S
T
Q
N
H
A
A
A
A
I
A
K
A
---------
G
I
P
V
Y
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
Y
F
K
D
G
P
---
L
N
M
I
L
D
D
G
G
D
L
T
-----------------------------------
N
L
I
H
-----------------------------------------
T
-------------------------------------
K
-----------------------------------------
Y
-------------------------------------
P
Q
L
L
P
G
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
-------------
T
T
M
D
E
A
-
C
Q
E
G
N
I
F
V
T
T
T
G
C
I
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
-
N
---
A
V
E
-
K
V
N
I
K
P
Q
V
--------------
D
R
Y
R
L
K
N
G
-
R
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
PD
K
Y
-
P
----------
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
C
A
H
L
-
G
K
L
N
V
K
L
T
L
T
E
K
Q
A
Q
Y
L
G
M
S
C
D
G
P
F
K
P
D
H
Y
R
Y
8
PsiBlast_PDB
92.65
56%
-78
- C3 -
3NJ4
3
SAHH_HUMAN
A:
[10-435]
------------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
R
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
T
L
G
A
E
V
Q
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
---------
G
I
P
V
Y
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
Y
F
K
D
G
P
---
L
N
M
I
L
D
D
G
G
D
L
T
-----------------------------------
N
L
I
H
-----------------------------------------
T
-------------------------------------
K
-----------------------------------------
Y
-------------------------------------
P
Q
L
L
P
G
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
-----
M
D
E
A
C
Q
E
G
---------
N
I
F
V
T
T
T
G
C
I
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
-
N
---
A
V
E
-
K
V
N
I
K
P
Q
V
--------------
D
R
Y
R
L
K
N
G
-
R
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
PD
K
Y
-
P
----------
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
S
C
D
G
P
F
K
P
D
H
Y
R
Y
51
PsiBlast_CBE
92.62
57%
-85
- C3 -
1KY5
3
SAHH_RAT
C:
[6-431]
------------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
M
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
A
L
G
A
E
V
R
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
---------
G
I
P
V
F
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
H
F
K
D
G
P
---
L
N
M
I
L
D
D
G
G
D
L
T
-----------------------------------
N
L
I
H
-----------------------------------------
T
-------------------------------------
K
-----------------------------------------
H
-------------------------------------
P
Q
L
L
S
G
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
E
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
-------------
T
T
M
D
E
A
-
C
K
E
G
N
I
F
V
T
T
T
G
C
V
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
-
N
---
A
V
E
-
K
V
NI
K
P
Q
V
--------------
D
R
Y
L
L
K
N
G
-
H
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
PD
K
Y
-
P
----------
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
P
I
N
G
P
F
K
P
D
H
Y
R
Y
60
PsiBlast_CBE
92.60
56%
-85
- C3 -
4PFJ
2
SAHH_HUMAN
B:
[7-432]
------------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
R
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
T
L
G
A
E
V
Q
W
S
S
C
N
I
F
S
T
Q
N
H
A
A
A
A
I
A
K
A
---------
G
I
P
V
Y
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
Y
F
K
D
G
P
---
L
N
M
I
L
D
D
G
G
D
L
T
-----------------------------------
N
L
I
H
-----------------------------------------
T
-------------------------------------
K
-----------------------------------------
Y
-------------------------------------
P
Q
L
L
P
G
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
-------------
T
T
M
D
E
A
-
C
Q
E
G
N
I
F
V
T
T
T
G
C
I
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
-
N
---
A
V
E
-
K
V
N
I
K
P
Q
V
--------------
D
R
Y
R
L
K
N
G
-
R
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
PD
K
Y
-
P
----------
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
C
A
H
L
-
G
L
N
V
K
L
T
-
L
T
E
K
Q
A
Q
Y
L
G
M
S
C
D
G
P
F
K
P
D
H
Y
R
Y
32
PsiBlast_CBE
92.59
57%
-90
- C3 -
1KY4
2
SAHH_RAT
C:
[6-431]
------------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
M
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
A
L
G
A
E
V
R
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
---------
G
I
P
V
F
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
H
F
K
D
G
P
---
L
N
M
I
L
D
D
G
G
D
L
T
-----------------------------------
N
L
I
H
-----------------------------------------
T
-------------------------------------
K
-----------------------------------------
H
-------------------------------------
P
Q
L
L
S
G
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
-------------
T
T
M
D
E
A
-
C
K
E
G
N
I
F
V
T
T
T
G
C
V
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
-
N
---
A
V
E
-
K
V
NI
K
P
Q
V
--------------
D
R
Y
L
L
K
N
G
-
H
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
PD
K
Y
-
P
----------
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
P
I
N
G
P
F
K
P
D
H
Y
R
Y
9
PsiBlast_PDB
92.59
57%
-85
- C3 -
1D4F
3
SAHH_RAT
A:
[6-431]
------------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
M
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
A
L
G
A
E
V
R
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
---------
G
I
P
V
F
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
H
F
K
D
G
P
---
L
N
M
I
L
D
D
G
G
D
L
T
-----------------------------------
N
L
I
H
-----------------------------------------
T
-------------------------------------
K
-----------------------------------------
H
-------------------------------------
P
Q
L
L
S
G
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
E
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
-------------
T
T
M
D
E
A
-
C
K
E
G
N
I
F
V
T
T
T
G
C
V
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
-
N
---
A
V
E
-
K
V
N
I
K
P
Q
V
--------------
D
R
Y
L
L
K
N
G
-
H
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
PD
K
Y
-
P
----------
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
P
I
N
G
P
F
K
P
D
H
Y
R
Y
33
PsiBlast_CBE
92.37
57%
-90
- C3 -
1KY4
2
SAHH_RAT
B:
[6-431]
------------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
M
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
A
L
G
A
E
V
R
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
---------
G
I
P
V
F
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
H
F
K
D
G
P
---
L
N
M
I
L
D
D
G
G
D
L
T
-----------------------------------
N
L
I
H
-----------------------------------------
T
-------------------------------------
K
-----------------------------------------
H
-------------------------------------
P
Q
L
L
S
G
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
-------------
T
T
M
D
E
A
-
C
K
E
G
N
I
F
V
T
T
T
G
C
V
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
-
N
---
A
V
E
-
K
V
NI
K
P
Q
V
--------------
D
R
Y
L
L
K
N
G
-
H
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
PD
K
Y
-
P
----------
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
P
I
N
G
P
F
K
P
D
H
Y
R
Y
2
PsiBlast_PDB
92.36
57%
-88
- C3 -
1B3R
2
SAHH_RAT
A:
[6-431]
------------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
M
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
A
L
G
A
E
V
R
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
---------
G
I
P
V
F
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
H
F
K
D
G
P
---
L
N
M
I
L
D
D
G
G
D
L
T
-----------------------------------
N
L
I
H
-----------------------------------------
T
-------------------------------------
K
-----------------------------------------
H
-------------------------------------
P
Q
L
L
S
G
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
-------------
T
T
M
D
E
A
-
C
K
E
G
N
I
F
V
T
T
T
G
C
V
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
-
N
---
A
V
E
-
K
V
NI
K
P
Q
V
--------------
D
R
Y
L
L
K
N
G
-
H
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
P
D
K
Y
-
P
----------
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
P
I
N
G
P
F
K
P
D
H
Y
R
Y
15
PsiBlast_PDB
92.31
51%
-78
- C3 -
4LVC
8
?
A:
[12-479]
--------
G
F
T
D
Y
I
V
K
D
I
A
L
A
D
F
G
R
K
E
I
S
L
A
E
T
E
M
P
G
L
M
A
T
R
E
E
Y
G
P
K
Q
P
L
K
G
A
R
I
A
G
S
L
H
M
T
I
Q
T
A
V
L
I
E
T
L
A
A
L
G
A
D
I
R
W
V
S
C
N
I
Y
S
T
Q
D
H
A
A
A
A
I
A
A
A
---------
G
I
P
V
F
A
V
K
G
E
T
L
T
E
Y
-
W
D
Y
T
A
K
L
-
F
D
W
H
G
G
G
T
P
N
M
I
L
D
D
G
G
D
A
T
-----------------------------------
M
L
V
H
-----------------------------------------
A
-------------------------------------
G
-----------------------------------------
Y
R
A
E
Q
GDT
A
F
L
D
K
PGS
E
E
E
E
I
F
Y
A
L
V
K
R
L
L
K
EKPKG
W
F
A
E
I
A
K
N
I
K
G
V
S
E
E
T
T
T
G
V
H
R
L
Y
E
M
A
N
K
G
T
L
L
F
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
V
D
G
I
R
R
G
T
D
V
M
L
S
G
K
V
A
M
V
A
G
F
G
D
V
G
K
G
S
A
A
S
L
R
Q
A
G
C
R
V
M
V
S
E
V
D
P
I
C
A
L
Q
A
A
M
E
G
Y
E
V
V
T
------------
M
E
D
A
A
--
P
R
A
D
I
F
V
T
A
T
G
N
K
D
I
I
T
I
E
H
M
R
A
M
K
D
R
A
I
V
C
N
I
G
H
F
D
N
E
I
Q
I
A
S
L
R
--
N
--
L
K
W
T
-
N
I
--
K
P
Q
V
-
D
--
E
I
E
---
F
P
-----
D
K
H
R
----
I
I
M
L
S
E
G
R
L
V
N
L
G
N
A
M
G
H
P
S
F
V
M
S
A
S
F
T
N
Q
T
L
A
Q
I
E
L
F
-------
A
N
N
K
D
S
K
Y
A
K
K
--
V
Y
V
L
P
K
T
L
D
E
K
V
A
R
L
H
L
A
K
I
G
V
K
L
T
E
L
R
K
D
Q
A
D
Y
I
G
V
K
Q
E
G
P
Y
K
S
D
H
Y
R
Y
71
PsiBlast_CBE
92.11
48%
-76
- C3 -
3CE6
3
SAHH_MYCTU
B:
[19-494]
-----------
D
F
K
I
A
D
L
S
L
A
D
F
G
R
K
E
L
R
I
A
E
H
E
M
P
G
L
M
S
L
R
R
E
Y
A
E
V
Q
P
L
K
G
A
R
I
S
G
S
L
H
M
T
V
Q
T
A
V
L
I
E
T
L
T
A
L
G
A
E
V
R
W
A
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
V
V
V
G
PHGTPDEPK
G
V
P
V
F
A
W
K
G
E
T
L
E
E
Y
W
W
A
A
E
Q
M
L
-
T
W
P
D
P
D
K
P
A
N
M
I
L
D
D
G
G
D
A
T
-----------------------------------
M
L
V
L
-----------------------------------------
R
G
M
Q
Y
E
K
A
G
V
V
P
P
A
E
EDDP
A
E
W
K
V
F
L
N
L
L
R
T
R
F
E
T
DKD
K
-----------------------------------------
W
-------------------------------------
T
K
I
A
E
S
V
K
G
V
T
E
E
T
T
T
G
V
L
R
L
Y
Q
F
A
A
A
G
D
L
A
F
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
K
Y
G
T
R
H
S
L
I
D
G
I
N
R
G
T
D
A
L
I
G
G
K
K
V
L
I
C
G
Y
G
D
V
G
K
G
C
A
E
A
M
K
G
Q
G
A
R
V
S
V
T
E
I
D
P
I
N
A
L
Q
A
M
M
E
G
F
D
V
V
T
---------
V
E
E
A
I
-----
G
D
A
D
I
V
V
T
A
T
G
N
K
D
I
I
M
L
E
H
I
K
A
M
K
D
H
A
I
L
G
N
I
G
H
F
D
N
E
I
D
M
A
G
L
E
R
-
S
--
G
A
T
R
V
N
V
--
K
P
Q
V
-
D
L
W
T
F
G
---
D
T
G
R
S
----------
I
I
V
L
S
E
G
R
L
L
N
L
G
N
A
T
G
H
P
S
F
V
M
S
N
S
F
A
N
Q
T
I
A
Q
I
E
L
W
T
K
ND
E
Y
-
D
N
----------
E
V
Y
R
L
P
K
H
L
D
E
K
V
A
R
I
H
V
E
A
L
G
G
H
L
T
K
L
T
K
E
Q
A
E
Y
L
G
V
D
V
E
G
P
Y
K
P
D
H
Y
R
Y
113
HHSearch
92.08
53%
-78
- C3 -
3OND
5
SAHH_LUPLU
A:
[12-488]
-------
T
S
G
R
E
Y
K
V
K
D
M
S
Q
A
D
F
G
R
L
E
I
E
L
A
E
V
E
M
P
G
L
M
A
S
R
S
E
F
G
P
S
Q
P
F
K
G
A
K
I
T
G
S
L
H
M
T
I
Q
T
A
V
L
I
E
T
L
T
A
L
G
A
E
V
R
W
C
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
R
D
---------
S
A
A
V
F
A
W
K
G
E
T
L
Q
E
Y
W
W
C
T
E
R
A
L
-
D
W
G
-
P
G
G
G
P
D
L
I
V
D
D
G
G
D
T
T
-----------------------------------
L
L
I
H
-----------------------------------------
E
-------------------------------------
G
V
K
A
E
E
I
Y
E
K
SGQFPDPDSTDN
A
E
F
K
I
V
L
S
I
I
K
E
G
L
K
T
DPK
R
Y
-------------------------------------
H
K
M
K
D
R
V
V
G
V
S
E
E
T
T
T
G
V
K
R
L
Y
Q
M
Q
A
N
G
T
L
L
F
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
H
S
L
P
D
G
L
M
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
A
A
L
K
Q
A
G
A
R
V
I
V
T
E
I
D
P
I
C
A
L
Q
A
T
M
E
G
L
Q
V
L
T
L
E
------------
D
--
V
V
S
E
A
D
I
F
V
T
T
T
G
N
K
D
I
I
M
L
D
H
M
K
K
M
K
N
N
A
I
V
C
N
I
G
H
F
D
N
E
I
D
M
L
G
L
E
T
-
H
PG
V
K
R
I
-
T
I
--
K
P
Q
T
-
D
--
R
W
V
---
F
--------
P
E
T
N
T
G
I
I
I
L
A
E
G
R
L
M
N
L
G
C
A
T
G
H
P
S
F
V
M
S
C
S
F
T
N
Q
V
I
A
Q
L
E
L
W
N
E
--
K
S
S
G
K
Y
-------
E
K
K
V
Y
V
L
P
K
H
L
D
E
K
V
A
A
L
H
L
E
K
L
G
A
K
L
T
K
L
S
K
D
Q
A
D
Y
I
S
V
P
V
E
G
P
Y
K
P
F
H
Y
R
Y
7
PsiBlast_PDB
91.63
56%
-82
- C3 -
1LI4
4
SAHH_HUMAN
A:
[7-432]
------------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
R
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
T
L
G
A
E
V
Q
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
---------
G
I
P
V
Y
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
Y
F
K
D
G
P
---
L
N
M
I
L
D
D
G
G
D
L
T
-----------------------------------
N
L
I
H
-----------------------------------------
T
-------------------------------------
K
-----------------------------------------
Y
-------------------------------------
P
Q
L
L
P
G
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
-----
M
D
E
A
C
Q
E
G
---------
N
I
F
V
T
T
T
G
C
I
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
-
N
---
A
V
E
-
K
V
N
I
K
P
Q
V
--------------
D
R
Y
R
L
K
N
G
-
R
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
PD
K
Y
-
P
----------
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
S
C
D
G
P
F
K
P
D
H
Y
R
Y
62
PsiBlast_CBE
90.90
51%
-80
- C3 -
3D64
2
SAHH_BURP1
B:
[33-494]
----------
Q
D
Y
V
V
A
D
I
A
L
A
G
W
G
R
K
E
L
N
I
A
E
T
E
M
P
G
L
V
Q
I
R
D
E
Y
K
A
Q
Q
P
L
K
G
A
R
I
A
G
S
L
H
M
T
I
Q
T
G
V
L
I
E
T
L
K
A
L
G
A
D
V
R
W
A
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
V
E
A
---------
G
T
P
V
F
A
F
K
G
E
S
L
D
E
Y
-
W
E
F
S
H
R
I
-
F
E
W
P
N
G
E
F
A
N
M
I
L
D
D
G
G
D
A
T
LLLILGSKAEKDRSVIARPTNEEEVALFKSIERHL
E
I
D
G
-----------------------------------------
S
-------------------------------------
W
-----------------------------------------
Y
-------------------------------------
S
K
R
L
A
H
I
K
G
V
T
E
E
T
T
T
G
V
H
R
L
Y
Q
M
E
K
D
G
R
L
P
F
P
A
F
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
V
D
G
I
K
R
A
T
D
V
M
I
A
G
K
I
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
S
L
R
G
L
G
A
T
V
W
V
T
E
I
D
P
I
C
A
L
Q
A
A
M
E
G
Y
R
V
V
T
---------
M
E
Y
A
A
D
-----
K
A
D
I
F
V
T
A
T
G
N
Y
H
V
I
N
H
D
H
M
K
A
M
R
H
N
A
I
V
C
N
I
G
H
F
D
S
E
I
D
V
A
S
T
R
Q
----
Y
Q
W
E
-
N
I
--
K
P
Q
V
D
H
--
I
I
F
---
P
D
G
K
R
----------
V
I
L
L
A
E
G
R
L
V
N
L
G
C
A
T
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
T
L
A
Q
I
E
L
F
T
R
GG
E
Y
-
A
N
----------
K
V
Y
V
L
P
K
H
L
D
E
K
V
A
R
L
H
L
A
R
I
G
A
Q
L
S
E
L
S
D
D
Q
A
A
Y
I
G
V
S
K
A
G
P
F
K
P
D
H
Y
R
Y
12
PsiBlast_PDB
90.61
51%
-79
- C3 -
3D64
2
SAHH_BURP1
A:
[33-494]
----------
Q
D
Y
V
V
A
D
I
A
L
A
G
W
G
R
K
E
L
N
I
A
E
T
E
M
P
G
L
V
Q
I
R
D
E
Y
K
A
Q
Q
P
L
K
G
A
R
I
A
G
S
L
H
M
T
I
Q
T
G
V
L
I
E
T
L
K
A
L
G
A
D
V
R
W
A
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
V
E
A
---------
G
T
P
V
F
A
F
K
G
E
S
L
D
E
Y
-
W
E
F
S
H
R
I
-
F
E
W
P
N
G
E
F
A
N
M
I
L
D
D
G
G
D
A
T
L
L
L
I
L
G
S
K
A
E
K
DRSVIARPTN
E
E
E
V
A
L
F
K
S
I
E
R
H
L
E
I
D
G
-----------------------------------------
S
-------------------------------------
W
-----------------------------------------
Y
-------------------------------------
S
K
R
L
A
H
I
K
G
V
T
E
E
T
T
T
G
V
H
R
L
Y
Q
M
E
K
D
G
R
L
P
F
P
A
F
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
V
D
G
I
K
R
A
T
D
V
M
I
A
G
K
I
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
S
L
R
G
L
G
A
T
V
W
V
T
E
I
D
P
I
C
A
L
Q
A
A
M
E
G
Y
R
V
V
T
---------
M
E
Y
A
A
D
-----
K
A
D
I
F
V
T
A
T
G
N
Y
H
V
I
N
H
D
H
M
K
A
M
R
H
N
A
I
V
C
N
I
G
H
F
D
S
E
I
D
V
A
S
T
R
Q
----
Y
Q
W
E
-
N
I
--
K
P
Q
V
D
H
--
I
I
F
---
P
D
G
K
R
----------
V
I
L
L
A
E
G
R
L
V
N
L
G
C
A
T
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
T
L
A
Q
I
E
L
F
T
R
GG
E
Y
-
A
N
----------
K
V
Y
V
L
P
K
H
L
D
E
K
V
A
R
L
H
L
A
R
I
G
A
Q
L
S
E
L
S
D
D
Q
A
A
Y
I
G
V
S
K
A
G
P
F
K
P
D
H
Y
R
Y
14
PsiBlast_PDB
90.36
55%
-81
- C3 -
1A7A
3
SAHH_HUMAN
A:
[7-432]
------------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
R
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
T
L
G
A
E
V
Q
W
S
S
C
N
I
F
S
T
Q
N
H
A
A
A
A
I
A
K
A
---------
G
I
P
V
Y
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
Y
F
K
D
G
P
---
L
N
M
I
L
D
D
G
G
D
L
T
-----------------------------------
N
L
I
H
-----------------------------------------
T
-------------------------------------
K
-----------------------------------------
Y
-------------------------------------
P
Q
L
L
P
G
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
--------
M
D
E
A
C
Q
E
G
------
N
I
F
V
T
T
T
G
C
I
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
-
N
---
A
V
E
-
K
V
N
I
K
P
Q
V
--------------
D
R
Y
R
L
K
N
G
-
R
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
PD
K
Y
-
P
----------
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
S
C
D
G
P
F
K
P
D
H
Y
R
Y
89
PsiBlast_CBE
90.26
47%
-72
- C3 -
3ONF
5
SAHH_LUPLU
B:
[16-488]
-----------
E
Y
K
V
K
D
M
S
Q
A
D
F
G
R
L
E
I
E
L
A
E
V
E
M
P
G
L
M
A
S
R
S
E
F
G
P
S
Q
P
F
K
G
A
K
I
T
G
S
L
H
M
T
I
Q
T
A
V
L
I
E
T
L
T
A
L
G
A
E
V
R
W
C
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
R
D
---------
S
A
A
V
F
A
W
K
G
E
T
L
Q
E
Y
W
W
C
T
E
R
A
--
L
D
W
G
P
G
G
G
P
D
L
I
V
D
D
G
G
D
T
T
-----------------------------------
L
L
I
H
E
G
V
K
A
E
E
I
Y
E
K
SG
Q
F
P
D
PDSTDN
A
E
F
K
I
V
L
S
I
I
K
E
G
L
K
T
DP
K
-------------------------------------
R
-----------------------------------------
Y
-------------------------------------
H
K
M
K
D
R
V
V
G
V
S
E
E
T
T
T
G
V
K
R
L
Y
Q
M
Q
A
N
G
T
L
L
F
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
H
S
L
P
D
G
L
M
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
A
A
L
K
Q
A
G
A
R
V
I
V
T
E
I
D
P
I
C
A
L
Q
A
T
M
E
G
L
Q
V
L
T
-----
L
E
D
---------
V
V
S
E
A
D
I
F
V
T
T
T
G
N
K
D
I
I
M
L
D
H
M
K
K
M
K
N
N
A
I
V
C
N
I
G
H
F
D
N
E
I
D
M
L
G
L
-----------
E
T
--
H
P
G
V
-
K
--
R
I
T
IKP
Q
T
D
R
W
V
F
P
E
T
N
T
-
G
-
I
I
I
L
A
E
G
R
L
M
N
L
G
C
A
T
G
H
P
S
F
V
M
S
C
S
F
T
N
Q
V
I
A
Q
L
E
L
W
N
E
--
K
------
S
S
G
K
Y
E
K
-
K
V
Y
V
L
P
K
H
L
D
E
K
V
A
A
L
H
L
E
K
L
G
A
K
L
T
K
L
S
K
D
Q
A
D
Y
I
S
V
P
V
E
G
P
Y
K
P
F
H
Y
R
Y
61
PsiBlast_CBE
90.19
51%
-74
- C3 -
3GLQ
3
SAHH_BURP1
B:
[33-494]
----------
Q
D
Y
V
V
A
D
I
A
L
A
G
W
G
R
K
E
L
N
I
A
E
T
E
M
P
G
L
V
Q
I
R
D
E
Y
K
A
Q
Q
P
L
K
G
A
R
I
A
G
S
L
H
M
T
I
Q
T
G
V
L
I
E
T
L
K
A
L
G
A
D
V
R
W
A
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
V
E
A
---------
G
T
P
V
F
A
F
K
G
E
S
L
D
E
Y
-
W
E
F
S
H
R
I
-
F
E
W
P
N
G
E
F
A
N
M
I
L
D
D
G
G
D
A
T
LLLILGSKAEKDRSVIARPTNEEEVALFKSIERHL
E
I
D
G
-----------------------------------------
S
-------------------------------------
W
-----------------------------------------
Y
-------------------------------------
S
K
R
L
A
H
I
K
G
V
T
E
E
T
T
T
G
V
H
R
L
Y
Q
M
E
K
D
G
R
L
P
F
P
A
F
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
V
D
G
I
K
R
A
T
D
V
M
I
A
G
K
I
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
S
L
R
G
L
G
A
T
V
W
V
T
E
I
D
P
I
C
A
L
Q
A
A
M
E
G
Y
R
V
V
T
---------
M
E
Y
A
A
D
-----
K
A
D
I
F
V
T
A
T
G
N
Y
H
V
I
N
H
D
H
M
K
A
M
R
H
N
A
I
V
C
N
I
G
H
F
D
S
E
I
D
V
A
S
T
R
Q
----
Y
Q
W
E
-
N
I
--
K
P
Q
V
D
H
--
I
I
F
---
P
D
G
K
R
----------
V
I
L
L
A
E
G
R
L
V
N
L
G
C
A
T
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
T
L
A
Q
I
E
L
F
T
R
GG
E
Y
-
A
N
----------
K
V
Y
V
L
P
K
H
L
D
E
K
V
A
R
L
H
L
A
R
I
G
A
Q
L
S
E
L
S
D
D
Q
A
A
Y
I
G
V
S
K
A
G
P
F
K
P
D
H
Y
R
Y
92
PsiBlast_CBE
90.13
47%
-70
- C3 -
3ONE
5
SAHH_LUPLU
A:
[16-488]
-----------
E
Y
K
V
K
D
M
S
Q
A
D
F
G
R
L
E
I
E
L
A
E
V
E
M
P
G
L
M
A
S
R
S
E
F
G
P
S
Q
P
F
K
G
A
K
I
T
G
S
L
H
M
T
I
Q
T
A
V
L
I
E
T
L
T
A
L
G
A
E
V
R
W
C
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
R
D
---------
S
A
A
V
F
A
W
K
G
E
T
L
Q
E
Y
W
W
C
T
E
R
A
--
L
D
W
G
P
G
G
G
P
D
L
I
V
D
D
G
G
D
T
T
-----------------------------------
L
L
I
H
E
G
V
K
A
E
E
I
Y
E
K
SGQFPDPDSTDN
A
E
F
K
I
V
L
S
I
I
K
E
G
L
K
T
DP
K
-------------------------------------
R
-----------------------------------------
Y
-------------------------------------
H
K
M
K
D
R
V
V
G
V
S
E
E
T
T
T
G
V
K
R
L
Y
Q
M
Q
A
N
G
T
L
L
F
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
H
S
L
P
D
G
L
M
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
A
A
L
K
Q
A
G
A
R
V
I
V
T
E
I
D
P
I
C
A
L
Q
A
T
M
E
G
L
Q
V
L
T
-----
L
E
D
---------
V
V
S
E
A
D
I
F
V
T
T
T
G
N
K
D
I
I
M
L
D
H
M
K
K
M
K
N
N
A
I
V
C
N
I
G
H
F
D
N
E
I
D
M
L
G
L
-----------
E
T
--
H
P
G
V
-
K
--
R
I
T
IKP
Q
T
D
R
W
V
F
P
E
T
N
T
-
G
-
I
I
I
L
A
E
G
R
L
M
N
L
G
C
A
T
G
H
P
S
F
V
M
S
C
S
F
T
N
Q
V
I
A
Q
L
E
L
W
N
E
--
K
------
S
S
G
K
Y
E
K
-
K
V
Y
V
L
P
K
H
L
D
E
K
V
A
A
L
H
L
E
K
L
G
A
K
L
T
K
L
S
K
D
Q
A
D
Y
I
S
V
P
V
E
G
P
Y
K
P
F
H
Y
R
Y
91
PsiBlast_CBE
89.96
47%
-70
- C3 -
3ONE
6
SAHH_LUPLU
B:
[16-488]
-----------
E
Y
K
V
K
D
M
S
Q
A
D
F
G
R
L
E
I
E
L
A
E
V
E
M
P
G
L
M
A
S
R
S
E
F
G
P
S
Q
P
F
K
G
A
K
I
T
G
S
L
H
M
T
I
Q
T
A
V
L
I
E
T
L
T
A
L
G
A
E
V
R
W
C
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
R
D
---------
S
A
A
V
F
A
W
K
G
E
T
L
Q
E
Y
W
W
C
T
E
R
A
--
L
D
W
G
P
G
G
G
P
D
L
I
V
D
D
G
G
D
T
T
-----------------------------------
L
L
I
H
E
G
V
K
A
E
E
I
Y
E
K
SGQFPDPDSTDN
A
E
F
K
I
V
L
S
I
I
K
E
G
L
K
T
DP
K
-------------------------------------
R
-----------------------------------------
Y
-------------------------------------
H
K
M
K
D
R
V
V
G
V
S
E
E
T
T
T
G
V
K
R
L
Y
Q
M
Q
A
N
G
T
L
L
F
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
H
S
L
P
D
G
L
M
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
A
A
L
K
Q
A
G
A
R
V
I
V
T
E
I
D
P
I
C
A
L
Q
A
T
M
E
G
L
Q
V
L
T
-----
L
E
D
---------
V
V
S
E
A
D
I
F
V
T
T
T
G
N
K
D
I
I
M
L
D
H
M
K
K
M
K
N
N
A
I
V
C
N
I
G
H
F
D
N
E
I
D
M
L
G
L
-----------
E
T
--
H
P
G
V
-
K
--
R
I
T
IKP
Q
T
D
R
W
V
F
P
E
T
N
T
-
G
-
I
I
I
L
A
E
G
R
L
M
N
L
G
C
A
T
G
H
P
S
F
V
M
S
C
S
F
T
N
Q
V
I
A
Q
L
E
L
W
N
E
--
K
------
S
S
G
K
Y
E
K
-
K
V
Y
V
L
P
K
H
L
D
E
K
V
A
A
L
H
L
E
K
L
G
A
K
L
T
K
L
S
K
D
Q
A
D
Y
I
S
V
P
V
E
G
P
Y
K
P
F
H
Y
R
Y
90
PsiBlast_CBE
89.54
47%
-72
- C3 -
3ONF
4
SAHH_LUPLU
A:
[16-488]
-----------
E
Y
K
V
K
D
M
S
Q
A
D
F
G
R
L
E
I
E
L
A
E
V
E
M
P
G
L
M
A
S
R
S
E
F
G
P
S
Q
P
F
K
G
A
K
I
T
G
S
L
H
M
T
I
Q
T
A
V
L
I
E
T
L
T
A
L
G
A
E
V
R
W
C
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
R
D
---------
S
A
A
V
F
A
W
K
G
E
T
L
Q
E
Y
W
W
C
T
E
R
A
--
L
D
W
G
P
G
G
G
P
D
L
I
V
D
D
G
G
D
T
T
-----------------------------------
L
L
I
H
E
G
V
K
A
E
E
I
Y
E
K
SGQFPDPDSTDN
A
E
F
K
I
V
L
S
I
I
K
E
G
L
K
T
DP
K
-------------------------------------
R
-----------------------------------------
Y
-------------------------------------
H
K
M
K
D
R
V
V
G
V
S
E
E
T
T
T
G
V
K
R
L
Y
Q
M
Q
A
N
G
T
L
L
F
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
H
S
L
P
D
G
L
M
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
A
A
L
K
Q
A
G
A
R
V
I
V
T
E
I
D
P
I
C
A
L
Q
A
T
M
E
G
L
Q
V
L
T
-----
L
E
D
---------
V
V
S
E
A
D
I
F
V
T
T
T
G
N
K
D
I
I
M
L
D
H
M
K
K
M
K
N
N
A
I
V
C
N
I
G
H
F
D
N
E
I
D
M
L
G
L
-----------
E
T
--
H
P
G
V
-
K
--
R
I
T
IKP
Q
T
D
R
W
V
F
P
E
T
N
T
-
G
-
I
I
I
L
A
E
G
R
L
M
N
L
G
C
A
T
G
H
P
S
F
V
M
S
C
S
F
T
N
Q
V
I
A
Q
L
E
L
W
N
E
--
K
------
S
S
G
K
Y
E
K
-
K
V
Y
V
L
P
K
H
L
D
E
K
V
A
A
L
H
L
E
K
L
G
A
K
L
T
K
L
S
K
D
Q
A
D
Y
I
S
V
P
V
E
G
P
Y
K
P
F
H
Y
R
Y
93
PsiBlast_CBE
89.33
47%
-72
- C3 -
3OND
6
SAHH_LUPLU
B:
[16-488]
-----------
E
Y
K
V
K
D
M
S
Q
A
D
F
G
R
L
E
I
E
L
A
E
V
E
M
P
G
L
M
A
S
R
S
E
F
G
P
S
Q
P
F
K
G
A
K
I
T
G
S
L
H
M
T
I
Q
T
A
V
L
I
E
T
L
T
A
L
G
A
E
V
R
W
C
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
R
D
---------
S
A
A
V
F
A
W
K
G
E
T
L
Q
E
Y
W
W
C
T
E
R
A
--
L
D
W
G
P
G
G
G
P
D
L
I
V
D
D
G
G
D
T
T
-----------------------------------
L
L
I
H
E
G
V
K
A
E
E
I
Y
E
K
SGQFPDPDSTDN
A
E
F
K
I
V
L
S
I
I
K
E
G
L
K
T
DP
K
-------------------------------------
R
-----------------------------------------
Y
-------------------------------------
H
K
M
K
D
R
V
V
G
V
S
E
E
T
T
T
G
V
K
R
L
Y
Q
M
Q
A
N
G
T
L
L
F
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
H
S
L
P
D
G
L
M
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
A
A
L
K
Q
A
G
A
R
V
I
V
T
E
I
D
P
I
C
A
L
Q
A
T
M
E
G
L
Q
V
L
T
-----
L
E
D
---------
V
V
S
E
A
D
I
F
V
T
T
T
G
N
K
D
I
I
M
L
D
H
M
K
K
M
K
N
N
A
I
V
C
N
I
G
H
F
D
N
E
I
D
M
L
G
L
-----------
E
T
--
H
P
G
V
-
K
--
R
I
T
IKP
Q
T
D
R
W
V
F
P
E
T
N
T
-
G
-
I
I
I
L
A
E
G
R
L
M
N
L
G
C
A
T
G
H
P
S
F
V
M
S
C
S
F
T
N
Q
V
I
A
Q
L
E
L
W
N
E
--
K
------
S
S
G
K
Y
E
K
-
K
V
Y
V
L
P
K
H
L
D
E
K
V
A
A
L
H
L
E
K
L
G
A
K
L
T
K
L
S
K
D
Q
A
D
Y
I
S
V
P
V
E
G
P
Y
K
P
F
H
Y
R
Y
94
PsiBlast_CBE
89.24
47%
-72
- C3 -
3OND
5
SAHH_LUPLU
A:
[16-488]
-----------
E
Y
K
V
K
D
M
S
Q
A
D
F
G
R
L
E
I
E
L
A
E
V
E
M
P
G
L
M
A
S
R
S
E
F
G
P
S
Q
P
F
K
G
A
K
I
T
G
S
L
H
M
T
I
Q
T
A
V
L
I
E
T
L
T
A
L
G
A
E
V
R
W
C
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
R
D
---------
S
A
A
V
F
A
W
K
G
E
T
L
Q
E
Y
W
W
C
T
E
R
A
--
L
D
W
G
P
G
G
G
P
D
L
I
V
D
D
G
G
D
T
T
-----------------------------------
L
L
I
H
E
G
V
K
A
E
E
I
Y
E
K
SGQFPDPDSTDN
A
E
F
K
I
V
L
S
I
I
K
E
G
L
K
T
DP
K
-------------------------------------
R
-----------------------------------------
Y
-------------------------------------
H
K
M
K
D
R
V
V
G
V
S
E
E
T
T
T
G
V
K
R
L
Y
Q
M
Q
A
N
G
T
L
L
F
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
H
S
L
P
D
G
L
M
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
A
A
L
K
Q
A
G
A
R
V
I
V
T
E
I
D
P
I
C
A
L
Q
A
T
M
E
G
L
Q
V
L
T
-----
L
E
D
---------
V
V
S
E
A
D
I
F
V
T
T
T
G
N
K
D
I
I
M
L
D
H
M
K
K
M
K
N
N
A
I
V
C
N
I
G
H
F
D
N
E
I
D
M
L
G
L
-----------
E
T
--
H
P
G
V
-
K
--
R
I
T
IKP
Q
T
D
R
W
V
F
P
E
T
N
T
-
G
-
I
I
I
L
A
E
G
R
L
M
N
L
G
C
A
T
G
H
P
S
F
V
M
S
C
S
F
T
N
Q
V
I
A
Q
L
E
L
W
N
E
--
K
------
S
S
G
K
Y
E
K
-
K
V
Y
V
L
P
K
H
L
D
E
K
V
A
A
L
H
L
E
K
L
G
A
K
L
T
K
L
S
K
D
Q
A
D
Y
I
S
V
P
V
E
G
P
Y
K
P
F
H
Y
R
Y
96
PsiBlast_CBE
89.16
47%
-90
- C3 -
3MTG
2
SAHH2_HUMAN
A:
[15-444]
--------
G
S
S
N
F
C
V
K
N
I
K
Q
A
E
F
G
R
R
E
I
E
I
A
E
Q
D
M
S
A
L
I
S
L
R
K
R
A
Q
G
E
K
P
L
A
G
A
K
I
V
G
C
T
H
I
T
A
Q
T
A
V
L
I
E
T
L
C
A
L
G
A
Q
C
R
W
S
A
C
N
I
Y
S
T
Q
N
E
V
A
A
A
L
A
E
A
---------
G
V
A
V
F
A
W
K
G
E
S
E
D
D
F
W
W
C
I
D
R
C
V
-
N
M
D
G
--
W
Q
A
N
M
I
L
D
D
G
G
D
L
T
-----------------------------------
H
W
V
Y
-----------------------------------------
K
-------------------------------------
K
-----------------------------------------
Y
-------------------------------------
P
N
V
F
K
K
I
R
G
I
V
E
E
S
V
T
G
V
H
R
L
Y
Q
L
S
K
A
G
K
L
C
V
P
A
M
N
V
N
D
S
V
T
K
Q
K
F
D
N
L
Y
C
C
R
E
S
I
L
D
G
L
K
R
T
T
D
V
M
F
G
G
K
Q
V
V
V
C
G
Y
G
E
V
G
K
G
C
C
A
A
L
K
A
L
G
A
I
V
Y
I
T
E
I
D
P
I
C
A
L
Q
A
C
M
D
G
F
R
V
V
K
-----
L
N
E
---------
V
I
R
Q
V
D
V
V
I
T
C
T
G
N
K
N
V
V
T
R
E
H
L
D
R
M
K
N
S
C
I
V
C
N
M
G
H
S
N
T
E
I
D
V
T
S
L
R
T
P
E
--
L
T
W
E
-
R
V
--
R
S
Q
V
D
H
--
V
I
W
---
P
D
G
K
R
----------
V
V
L
L
A
E
G
R
L
L
N
L
S
C
S
T
V
-
P
T
F
V
L
S
I
T
A
T
T
Q
A
L
A
L
I
E
L
Y
N
----------
A
P
E
G
R
Y
K
Q
D
V
Y
L
L
P
K
K
M
D
E
Y
V
A
S
L
H
L
P
S
F
D
A
H
L
T
E
L
A
D
D
Q
A
K
Y
L
G
L
N
K
N
G
P
F
K
P
N
Y
Y
R
Y
13
PsiBlast_PDB
88.98
51%
-74
- C3 -
3GLQ
3
SAHH_BURP1
A:
[33-494]
----------
Q
D
Y
V
V
A
D
I
A
L
A
G
W
G
R
K
E
L
N
I
A
E
T
E
M
P
G
L
V
Q
I
R
D
E
Y
K
A
Q
Q
P
L
K
G
A
R
I
A
G
S
L
H
M
T
I
Q
T
G
V
L
I
E
T
L
K
A
L
G
A
D
V
R
W
A
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
V
E
A
---------
G
T
P
V
F
A
F
K
G
E
S
L
D
E
Y
-
W
E
F
S
H
R
I
-
F
E
W
P
N
G
E
F
A
N
M
I
L
D
D
G
G
D
A
T
L
L
L
I
L
G
S
K
A
E
K
D
RSVIARPTN
E
E
E
V
A
L
F
K
S
I
E
R
H
L
E
I
D
G
-----------------------------------------
S
-------------------------------------
W
-----------------------------------------
Y
-------------------------------------
S
K
R
L
A
H
I
K
G
V
T
E
E
T
T
T
G
V
H
R
L
Y
Q
M
E
K
D
G
R
L
P
F
P
A
F
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
V
D
G
I
K
R
A
T
D
V
M
I
A
G
K
I
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
S
L
R
G
L
G
A
T
V
W
V
T
E
I
D
P
I
C
A
L
Q
A
A
M
E
G
Y
R
V
V
T
---------
M
E
Y
A
A
D
-----
K
A
D
I
F
V
T
A
T
G
N
Y
H
V
I
N
H
D
H
M
K
A
M
R
H
N
A
I
V
C
N
I
G
H
F
D
S
E
I
D
V
A
S
T
R
Q
----
Y
Q
W
E
-
N
I
--
K
P
Q
V
D
H
--
I
I
F
---
P
D
G
K
R
----------
V
I
L
L
A
E
G
R
L
V
N
L
G
C
A
T
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
T
L
A
Q
I
E
L
F
T
R
GG
E
Y
-
A
N
----------
K
V
Y
V
L
P
K
H
L
D
E
K
V
A
R
L
H
L
A
R
I
G
A
Q
L
S
E
L
S
D
D
Q
A
A
Y
I
G
V
S
K
A
G
P
F
K
P
D
H
Y
R
Y
95
PsiBlast_CBE
88.62
47%
-91
- C3 -
3MTG
2
SAHH2_HUMAN
B:
[15-444]
--------
G
S
S
N
F
C
V
K
N
I
K
Q
A
E
F
G
R
R
E
I
E
I
A
E
Q
D
M
S
A
L
I
S
L
R
K
R
A
Q
G
E
K
P
L
A
G
A
K
I
V
G
C
T
H
I
T
A
Q
T
A
V
L
I
E
T
L
C
A
L
G
A
Q
C
R
W
S
A
C
N
I
Y
S
T
Q
N
E
V
A
A
A
L
A
E
A
---------
G
V
A
V
F
A
W
K
G
E
S
E
D
D
F
W
W
C
I
D
R
C
V
-
N
M
-----
Q
A
N
M
I
L
D
D
G
G
D
L
T
-----------------------------------
H
W
V
Y
-----------------------------------------
K
-------------------------------------
K
-----------------------------------------
Y
-------------------------------------
P
N
V
F
K
K
I
R
G
I
V
E
E
S
V
T
G
V
H
R
L
Y
Q
L
S
K
A
G
K
L
C
V
P
A
M
N
V
N
D
S
V
T
K
Q
K
F
D
N
L
Y
C
C
R
E
S
I
L
D
G
L
K
R
T
T
D
V
M
F
G
G
K
Q
V
V
V
C
G
Y
G
E
V
G
K
G
C
C
A
A
L
K
A
L
G
A
I
V
Y
I
T
E
I
D
P
I
C
A
L
Q
A
C
M
D
G
F
R
V
V
K
-----
L
N
E
---------
V
I
R
Q
V
D
V
V
I
T
C
T
G
N
K
N
V
V
T
R
E
H
L
D
R
M
K
N
S
C
I
V
C
N
M
G
H
S
N
T
E
I
D
V
T
S
L
R
T
P
E
--
L
T
W
E
-
R
V
--
R
S
Q
V
D
H
--
V
I
W
---
P
D
G
K
R
----------
V
V
L
L
A
E
G
R
L
L
N
----
T
V
-
P
T
F
V
L
S
I
T
A
T
T
Q
A
L
A
L
I
E
L
Y
N
----------
A
P
E
G
R
Y
K
Q
D
V
Y
L
L
P
K
K
M
D
E
Y
V
A
S
L
H
L
P
S
F
D
A
H
L
T
E
L
A
D
D
Q
A
K
Y
L
G
L
N
K
N
G
P
F
K
P
N
Y
Y
R
Y
117
HHSearch
81.21
37%
-84
- C3 -
3X2F
22
SAHH_THEMA
A:
[3-407]
---------------------
N
T
G
E
M
K
I
N
W
V
S
R
Y
M
P
L
L
N
K
I
A
E
E
Y
S
R
E
K
P
L
S
G
F
T
V
G
M
S
I
H
L
E
A
K
T
A
Y
L
A
I
T
L
S
K
L
G
A
K
V
V
I
T
G
S
N
P
L
S
T
Q
D
D
V
A
E
A
L
R
S
K
---------
G
I
T
V
Y
A
R
R
T
H
D
E
S
I
Y
R
E
N
L
M
K
V
L
-
D
E
-----
R
P
D
F
I
I
D
D
G
G
D
L
T
-----------------------------------
V
I
S
H
-----------------------------------------
T
-------------------------------------
E
-----------------------------------------
R
-------------------------------------
E
E
V
L
E
N
L
K
G
V
S
E
E
T
T
T
G
V
R
R
L
K
A
L
E
E
T
G
K
L
R
V
P
V
I
A
V
N
D
S
K
M
K
Y
L
F
D
N
R
Y
G
T
G
Q
S
T
W
D
A
I
M
R
N
T
N
L
L
V
A
G
K
N
V
V
V
A
G
Y
G
W
C
G
R
G
I
A
L
R
A
A
G
L
G
A
R
V
I
V
T
E
V
D
P
V
K
A
V
E
A
I
M
D
G
F
T
V
M
P
M
K
------------
E
--
A
V
K
I
A
D
F
V
I
T
A
S
G
N
T
D
V
L
S
K
E
D
I
L
S
L
K
D
G
A
V
L
A
N
A
G
H
F
N
V
E
I
P
V
R
V
L
E
E
I
A
--
V
E
K
F
-
E
A
--
R
P
N
V
-
T
--
G
Y
T
---
L
--------
E
N
G
-
K
T
V
F
L
L
A
E
G
R
L
V
N
L
A
A
G
D
G
H
P
V
E
I
M
D
L
S
F
A
L
Q
I
F
A
V
L
Y
L
L
E
N
--
H
R
--
K
M
-------
S
P
K
V
Y
M
L
P
D
E
I
D
E
R
V
A
R
M
K
L
D
S
L
G
V
K
I
D
E
L
T
E
K
Q
R
R
Y
L
R
S
W
Q
H
H
H
--------