@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0455: (2016-01-05 )
MTSTAFSSLPLSADLLANLDSLGYREMTPIQAQSLPLILQGHDLIAQAKTGSGKTAAFGLALLSPLNPRYFGCQALVLCPTRELADQVAKEIRRLARAADNIKVLTLCGGVPYGPQVASLEHGAHVVVGTPGRIQEHLRKGTLVLDGLNTLVLDEADRMLDMGFYDSIAEIIGQLPERRQTLLFSATYPDGIEKLAKTFMRDPRQVRVESLHADSQIEQRFFEIDPKQRMDAVVRLLQHFRPQSCVAFCQTRQQCQELADALKAQRISALALHGDLEQRERDQVLTVFANRSCNVLVATDVAARGLDIAALETVINVELARDPEVHIHRIGRSGRAGEKGLALSLVAPAEASRAQAIEDLQKQPLAWYALGQLKASPEPLLPPMSTLCIAGGRKDKVRPGDLLGALTGDAGLPGSAVGKIAIFDFQAFVAIERGLAHQALKRLSEGKIKGRSFKVRLL
Atome Classification :
(37 SA)
.........10........20........30........40--........50........60.---....--------------..-.------------------70----.-----..---.----.....80........90........100.......110.......120...------.....130.......--140........150.......160.-.......170..----.----.--..--.180.......190.......200.......-----210.-....-...220....-..-.230.......-240..-.....250.......260.......270.......280.......290.......300.......310.......320-----........330.......340.......-350........360.......370.......380.......390.......400.......410.......420.......430.......440.......450......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTSTAFSSLPL
S
A
D
L
L
A
N
L
D
SLGYREMTPIQAQS
L
P
L
I
L
QG--
H
D
L
I
A
QAKTGSGKT
A
A
F
G
L
A
L
---LSPL--------------NP-R------------------Y-----F-----G
C
---
Q
----
A
L
V
LCP
T
R
E
L
A
D
Q
V
A
K
E
I
R
R
L
A
R
AADN
I
K
V
L
T
LCGGVPYGPQVASL-EHG
A
------
H
V
V
VGT
P
G
R
I
Q
E
H
L
R--KG-
T
L
V
LDGL
N
T
L
V
LDE
A
D
R
M
L
D
-M-G
F
Y
D
S
I
A
E
I
I
G
Q----L----
P
--
E
R
--
R
Q
T
L
L
F
SATY
P
D
G
I
E
K
L
A
K
T
F
MRD
P
R
Q
V
R
V
E
-----SL-H-A
D
S
Q
-
I
E
Q
R
F
FEI
D
P
-
K
Q
-
R
M
D
A
V
V
R
L
L
Q
H-FR
P
Q
S
-
C
V
A
F
C
Q
T
R
Q
Q
C
Q
E
L
A
D
A
L
K
A
QR
I
S
A
L
A
LHG
D
L
E
Q
R
E
R
D
Q
V
L
T
V
FANRSC
N
V
L
V
A
T
D
V
AARG
L
D
I
A
A
L
E
T
V
I
N
V
E
LAR------DP
E
V
H
I
H
R
IGRSGRAGEK
G
L
A
L
S
L
VAPA-E-
A
S
R
A
Q
A
I
E
D
L
Q
KQPL
A
W
Y
A
LGQLKASPEPLLP
P
M
S
T
L
CIAGGRKDKVRP
G
D
L
L
G
ALTGDAGLPGSA
V
G
K
I
A
I
F
D
F
Q
A
F
V
A
I
E
R
G
L
A
H
Q
A
L
K
R
L
SEGKIKG
R
S
F
K
V
R
LL
1
PsiBlast_PDB
91.81
39%
-127
- C4 -
1HV8
5
H669_METJA
A:
[8-354]
-----
F
N
E
L
N
L
S
D
N
I
L
N
A
I
R
N
K
G
F
E
K
P
T
D
I
Q
M
K
V
I
P
L
F
L
N
D
E-
Y
N
I
V
A
Q
A
R
T
G
S
G
K
T
A
S
F
A
I
P
L
---
I
E
L
V
--------------
N
E
-
N
------------------
N
-----------
G
I
---
E
----
A
I
I
L
T
P
T
R
E
L
A
I
Q
V
A
D
E
I
E
S
L
-
K
G
N
K
N
L
K
I
A
K
I
Y
G
G
K
A
I
Y
P
Q
I
K
A
L
-
K
N
-
A
------
N
I
V
V
G
T
P
G
R
I
L
D
H
I
N
--
R
G
-
T
L
N
L
K
N
V
K
Y
F
I
L
D
E
A
D
E
M
L
N
-
M
-
G
F
I
K
D
V
E
K
I
L
N
A
----
C
----
N
--
K
D
--
K
R
I
L
L
F
S
A
T
M
P
R
E
I
L
N
L
A
K
K
Y
M
G
D
Y
S
F
I
K
A
K
----------
I
N
A
N
-
I
E
Q
S
Y
V
E
V
N
E
-
N
E
-
R
F
E
A
L
C
R
L
L
K
N
--
K
E
F
Y
-
G
L
V
F
C
K
T
K
R
D
T
K
E
L
A
S
M
L
R
D
I
G
F
K
A
G
A
I
H
G
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
I
R
I
L
I
A
T
D
V
M
S
R
G
I
D
V
N
D
L
N
C
V
I
N
Y
H
L
P
Q
------
N
P
E
S
Y
M
H
R
I
G
R
T
G
R
A
G
K
K
G
K
A
I
S
I
I
N
R
R
-
E
-
Y
K
K
L
R
Y
I
E
R
A
M
K
L
K
I
K
K
L
K
-----------------------------------------------------------------------------------------
108
HHSearch
91.07
39%
-119
- C4 -
1HV8
5
H669_METJA
A:
[4-364]
-
E
Y
M
N
F
N
E
L
N
L
S
D
N
I
L
N
A
I
R
N
K
G
F
E
K
P
T
D
I
Q
M
K
V
I
P
L
F
L
N
D
E-
Y
N
I
V
A
Q
A
R
T
G
S
G
K
T
A
S
F
A
I
P
L
---
I
E
L
V
--------------
N
E
--------------------
N
-----
N
-----
G
I
---
E
----
A
I
I
L
T
P
T
R
E
L
A
I
Q
V
A
D
E
I
E
S
L
K
G
N
K
-
N
L
K
I
A
K
I
Y
G
G
K
A
I
Y
P
Q
I
K
-
A
-
L
K
N
A
------
N
I
V
V
G
T
P
G
R
I
L
D
H
I
N
--
R
G
-
T
L
N
L
K
N
V
K
Y
F
I
L
D
E
A
D
E
M
L
N
-
M
-
G
F
I
K
D
V
E
K
I
L
N
A
----
C
----
N
--
K
D
--
K
R
I
L
L
F
S
A
T
M
P
R
E
I
L
N
L
A
K
K
Y
M
G
D
Y
S
F
I
K
A
---------
K
-
I
N
A
N
-
I
E
Q
S
Y
V
E
V
N
E
-
N
E
-
R
F
E
A
L
C
R
L
L
K
N
--
K
E
F
Y
-
G
L
V
F
C
K
T
K
R
D
T
K
E
L
A
S
M
L
R
D
I
G
F
K
A
G
A
I
H
G
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
I
R
I
L
I
A
T
D
V
M
S
R
G
I
D
V
N
D
L
N
C
V
I
N
Y
H
L
P
Q
------
N
P
E
S
Y
M
H
R
I
G
R
T
G
R
A
G
K
K
G
K
A
I
S
I
I
N
R
R
-
E
-
Y
K
K
L
R
Y
I
E
R
A
M
K
L
K
I
K
K
L
K
-----------------------------------------------------------------------------------------
110
HHSearch
90.46
37%
-126
- C4 -
2I4I
1
DDX3X_HUMAN
A:
[14-394]
--
I
E
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
---
L
S
Q
I
--------------
Y
S
-
D
GPG
E
A
L
R
A
M
K
E
NGRYGRR
K
-----
Q
-----
Y
P
---
I
----
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
R
S
-
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
------
H
L
L
V
A
T
P
G
R
L
V
D
M
M
E
--
R
G
-
K
I
G
L
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
D
-
M
-
G
F
E
P
Q
I
R
R
I
V
E
Q
----
D
TMPP
K
--
G
V
--
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
----------
T
S
E
N
-
I
T
Q
K
V
V
W
V
E
E
-
S
D
-
K
R
S
F
L
L
D
L
L
N
A
T
G
K
D
S
L
-
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
N
E
R
-
N
-
I
N
I
T
K
D
L
L
D
L
L
V
E
A
K
Q
E
V
P
S
W
L
E
N
M
A
Y
E
H
H
Y
-----------------------------------------------------------------------------
37
PsiBlast_CBE
90.11
34%
-139
- C4 -
2VSO
1
IF4A_YEAST
A:
[24-376]
-----
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
---
L
Q
R
I
--------------
D
T
-
S
------------------
V
-----
K
-----
A
P
---
Q
----
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
H
M
D
-
I
K
V
H
A
C
I
G
----------
L
--
R
D
A
------
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
Q
--
R
R
-
R
F
R
T
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
S
-
S
-
G
F
K
E
Q
I
Y
Q
I
F
T
L
----
L
----
P
--
P
T
--
T
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
-----
K
D
-
E
-
L
T
L
E
G
I
K
Q
F
Y
V
N
V
E
E
-
E
E
Y
K
Y
E
C
L
T
D
L
Y
D
S
-
I
S
V
T
Q
-
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
-
D
-
V
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
E
L
P
S
D
I
A
T
L
-----------------------------------------------------------------------------------
36
PsiBlast_CBE
90.00
34%
-140
- C4 -
2VSO
1
IF4A_YEAST
B:
[24-376]
-----
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
---
L
Q
R
I
--------------
D
T
-
S
------------------
V
-----
K
-----
A
P
---
Q
----
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
H
M
D
-
I
K
V
H
A
C
I
G
----------
L
--
R
D
A
------
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
Q
--
R
R
-
R
F
R
T
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
S
-
S
-
G
F
K
E
Q
I
Y
Q
I
F
T
L
----
L
----
P
--
P
T
--
T
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
-----
K
D
-
E
-
L
T
L
E
G
I
K
Q
F
Y
V
N
V
E
E
-
E
E
Y
K
Y
E
C
L
T
D
L
Y
D
S
-
I
S
V
T
Q
-
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
-
D
-
V
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
E
L
P
S
D
I
A
T
L
-----------------------------------------------------------------------------------
14
PsiBlast_PDB
89.80
36%
-130
- C4 -
2I4I
1
DDX3X_HUMAN
A:
[16-394]
----
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
---
L
S
Q
I
Y
S
DGPG
E
A
L
R
A
M
K
E
N
G
-
R
------------------
Y
-----
G
-----
R
R
---
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
R
S
-
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
------
H
L
L
V
A
T
P
G
R
L
V
D
M
M
E
--
R
G
-
K
I
G
L
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
D
-
M
-
G
F
E
P
Q
I
R
R
I
V
E
Q
DT--
M
----
P
--
P
K
GV
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
-----------
T
S
E
N
I
T
Q
K
V
V
W
V
E
E
-
S
D
-
K
R
S
F
L
L
D
L
L
N
A
-
T
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
N
E
R
-
N
-
I
N
I
T
K
D
L
L
D
L
L
V
E
A
K
Q
E
V
P
S
W
L
E
N
M
A
Y
E
H
H
Y
-----------------------------------------------------------------------------
34
PsiBlast_CBE
89.34
34%
-138
- C4 -
2VSX
1
IF4A_YEAST
B:
[24-376]
-----
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
---
L
Q
R
I
--------------
D
T
-
S
------------------
V
-----
K
-----
A
P
---
Q
----
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
H
M
D
-
I
K
V
H
A
C
I
G
----------
L
--
R
D
A
------
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
Q
--
R
R
-
R
F
R
T
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
S
-
S
-
G
F
K
E
Q
I
Y
Q
I
F
T
L
----
L
----
P
--
P
T
--
T
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
-----
K
D
-
E
-
L
T
L
E
G
I
K
Q
F
Y
V
N
V
E
E
-
E
E
Y
K
Y
E
C
L
T
D
L
Y
D
S
-
I
S
V
T
Q
-
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
-
D
-
V
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
E
L
P
S
D
I
A
T
L
-----------------------------------------------------------------------------------
35
PsiBlast_CBE
89.12
34%
-138
- C4 -
2VSX
1
IF4A_YEAST
A:
[24-376]
-----
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
---
L
Q
R
I
--------------
D
T
-
S
------------------
V
-----
K
-----
A
P
---
Q
----
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
H
M
D
-
I
K
V
H
A
C
I
G
----------
L
--
R
D
A
------
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
Q
--
R
R
-
R
F
R
T
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
S
-
S
-
G
F
K
E
Q
I
Y
Q
I
F
T
L
----
L
----
P
--
P
T
--
T
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
-----
K
D
-
E
-
L
T
L
E
G
I
K
Q
F
Y
V
N
V
E
E
-
E
E
Y
K
Y
E
C
L
T
D
L
Y
D
S
-
I
S
V
T
Q
-
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
-
D
-
V
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
E
L
P
S
D
I
A
T
L
-----------------------------------------------------------------------------------
28
PsiBlast_CBE
88.91
42%
-126
- C4 -
4KBF
1
?
B:
[3-354]
-----
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
AER
L
A
P
S
--------------
Q
E
-
R
------------------
G
-----
R
-----
K
P
---
R
----
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
---
L
T
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
------
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
--
Q
G
-
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
-
M
-
G
F
E
E
E
V
E
A
L
L
S
A
----
T
----
P
--
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
-----
K
--
D
-
E
P
V
T
-
Y
E
E
E
A
V
P
A
P
V
-
R
G
-
R
L
E
V
L
S
D
L
L
Y
V
-
A
S
P
D
R
-
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
R
-
E
-
R
R
D
V
E
A
L
E
R
A
V
G
R
R
F
K
R
V
N
-----------------------------------------------------------------------------------------
11
PsiBlast_PDB
88.87
42%
-115
- C4 -
4KBF
3
?
A:
[3-354]
-----
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
A
P
S
--------------
Q
E
-
R
------------------
G
-----
R
-----
K
P
---
R
----
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
---
L
T
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
------
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
--
Q
G
-
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
-
M
-
G
F
E
E
E
V
E
A
L
L
S
A
----
T
----
P
--
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
-----
K
--
D
-
E
P
V
T
-
Y
E
E
E
A
V
P
A
P
V
-
R
G
-
R
L
E
V
L
S
D
L
L
Y
V
-
A
S
P
D
R
-
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
R
-
E
-
R
R
D
V
E
A
L
E
R
A
V
G
R
R
F
K
R
V
N
-----------------------------------------------------------------------------------------
17
PsiBlast_PDB
88.67
35%
-114
- C4 -
4PXA
5
DDX3X_HUMAN
A:
[66-444]
----
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
---
L
S
Q
I
Y
S
DGPG
E
A
L
R
A
M
K
E
N
G
-
R
------------------
Y
-----
G
-----
R
R
---
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
R
S
-
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
------
H
L
L
V
A
T
P
G
R
L
V
D
M
M
E
--
R
G
-
K
I
G
L
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
V
-
M
-
G
F
E
P
Q
I
R
R
I
V
E
Q
DT--
M
----
P
--
P
K
GV
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
-----
R
V
-
G
-
S
T
S
E
N
I
T
Q
K
V
V
W
V
E
E
-
S
D
-
K
R
S
F
L
L
D
L
L
N
A
-
T
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
N
E
R
-
N
-
I
N
I
T
K
D
L
L
D
L
L
V
E
A
K
Q
E
V
P
S
W
L
E
N
M
A
Y
---------------------------------------------------------------------------------
27
PsiBlast_CBE
88.03
42%
-117
- C4 -
4KBG
4
?
B:
[3-354]
-----
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
AER
L
A
P
S
--------------
Q
E
-
R
------------------
G
-----
R
-----
K
P
---
R
----
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
---
L
T
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
------
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
--
Q
G
-
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
-
M
-
G
F
E
E
E
V
E
A
L
L
S
A
----
T
----
P
--
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
-----
K
--
D
-
E
P
V
T
-
Y
E
E
E
A
V
P
A
P
V
-
R
G
-
R
L
E
V
L
S
D
L
L
Y
V
-
A
S
P
D
R
-
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
R
-
E
-
R
R
D
V
E
A
L
E
R
A
V
G
R
R
F
K
R
V
N
-----------------------------------------------------------------------------------------
100
HHSearch
86.75
34%
-123
- C4 -
3EIQ
-
IF4A1_HUMAN
A:
[31-399]
--
V
D
S
F
D
D
M
N
L
S
E
S
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
L
P
C
I
K
G
--
Y
D
V
I
A
Q
A
Q
S
G
T
G
K
T
A
T
F
A
I
S
I
---
L
Q
Q
I
--------------
E
L
-
D
------------------
L
-----
K
-----
A
T
---
Q
----
A
L
V
L
A
P
T
R
E
L
A
Q
Q
I
Q
K
V
V
M
A
L
G
D
Y
M
-
G
A
S
C
H
A
C
I
G
G
T
N
V
R
A
E
V
Q
K
L
Q
M
E
A
P
------
H
I
I
V
G
T
P
G
R
V
F
D
M
L
N
--
R
R
-
Y
L
S
P
K
Y
I
K
M
F
V
L
D
E
A
D
E
M
L
S
-
R
-
G
F
K
D
Q
I
Y
D
I
F
Q
K
----
L
----
N
--
S
N
--
T
Q
V
V
L
L
S
A
T
M
P
S
D
V
L
E
V
T
K
K
F
M
R
D
P
I
R
I
L
V
K
-----
K
E
E
L
-
T
L
E
G
-
I
R
Q
F
Y
I
N
V
E
R
E
E
W
-
K
L
D
T
L
C
D
L
Y
E
T
-
L
T
I
T
Q
-
A
V
I
F
I
N
T
R
R
K
V
D
W
L
T
E
K
M
H
A
R
D
F
T
V
S
A
M
---
M
D
Q
K
E
R
D
V
I
M
R
E
F
R
S
G
---
V
L
I
T
T
D
L
L
A
--
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
T
------
N
R
E
N
Y
I
H
R
I
G
R
G
-------
V
A
I
N
M
V
T
E
E
-
D
-
K
R
T
L
R
D
I
E
T
F
Y
N
T
S
I
E
E
M
P
L
----------------------------------------------------------------------------------------
15
PsiBlast_PDB
86.66
35%
-112
- C4 -
4D25
4
?
A:
[51-404]
----
S
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
G
--
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
---
I
N
M
L
L
Q
------------
D
P
-
K
------------------
D
-----
L
I
S
E
N-
G
C
A
Q
P
Q
----
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
G
S
-
V
L
K
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
I
-
A
R
G
C
------
H
I
L
V
A
T
P
G
R
L
H
D
F
V
E
--
R
N
-
R
V
S
F
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
D
-
M
-
G
F
M
P
S
I
E
K
M
M
L
H
PTMV
E
----
T
--
T
K
--
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
-----
I
V
-
G
G
A
S
T
D
-
V
E
Q
I
F
I
E
V
T
K
-
Y
E
-
K
R
N
S
L
K
Q
L
I
E
E
-
N
D
G
K
R
-
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
------
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
S
D
-
Q
-
D
L
A
L
V
A
D
L
S
K
I
L
R
Q
A
D
Q
S
V
P
D
F
L
K
------------------------------------------------------------------------------------
103
HHSearch
86.43
36%
-104
- C4 -
2DB3
3
VASA1_DROME
A:
[56-418]
---
Q
H
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
---
L
S
K
L
--------------
L
E
-
D
------------------
P
H
E
L
E
L
G
-----
R
P
---
Q
----
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
E
S
-
Y
L
K
I
G
I
V
Y
G
G
T
S
F
R
H
Q
N
E
C
I
-
T
R
G
C
------
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
--
R
T
-
F
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
D
-
M
-
G
F
S
E
D
M
R
R
I
M
T
H
----
V
----
T
MR
P
E
--
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
-----
I
V
G
G
-
A
C
S
D
-
V
K
Q
T
I
Y
E
V
N
K
-
Y
A
-
K
R
S
K
L
I
E
I
L
S
E
--
Q
A
D
G
-
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
------
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
E
K
D
-
R
A
I
A
A
D
L
V
K
I
L
E
G
S
G
Q
T
V
P
D
F
L
R
-------------------------------------------------------------------------------------
32
PsiBlast_CBE
86.09
32%
-132
- C4 -
1XTI
4
DX39B_HUMAN
A:
[9-367]
----
G
F
R
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
L
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
---
L
Q
Q
L
--------------
E
P
-
V
------------------
T
-----
G
-----
Q
V
---
S
----
V
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
K
Y
M
P
N
V
K
V
A
V
F
F
G
G
L
S
I
K
K
D
E
E
V
L
-
K
K
N
C
P-----
H
I
V
V
G
T
P
G
R
I
L
A
L
A
R
--
N
K
-
S
L
N
L
K
H
I
K
H
F
I
L
D
E
C
D
K
M
L
E
Q
L
-
D
M
R
R
D
V
Q
E
I
F
R
M
----
T
----
P
--
H
E
--
K
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
M
E
I
F
V
D
D
ETKL
T
L
-
H
-
G
----
L
Q
Q
Y
Y
V
K
L
K
D
-
N
E
-
K
N
R
K
L
F
D
L
L
D
V
-
L
E
F
N
Q
-
V
V
I
F
V
K
S
V
Q
R
C
I
A
L
A
Q
L
L
V
E
Q
N
F
P
A
I
A
I
H
R
G
M
P
Q
E
E
R
L
S
R
Y
Q
Q
F
K
D
F
Q
R
R
I
L
V
A
T
N
L
F
G
R
G
M
D
I
E
R
V
N
I
A
F
N
Y
D
M
P
E
------
D
S
D
T
Y
L
H
R
V
A
R
A
G
R
F
G
T
K
G
L
A
I
T
F
V
--
S
-
D
-
E
N
D
A
K
I
L
N
D
V
Q
D
R
F
E
V
N
I
S
E
L
P
D
E
I
D
I
S
S
Y
I
E
Q
---------------------------------------------------------------------------
5
PsiBlast_PDB
85.63
34%
-126
- C4 -
2HXY
-
IF4A3_HUMAN
A:
[39-393]
----
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
---
L
Q
C
L
--------------
D
I
-
Q
------------------
V
-----
R
-----
E
T
---
Q
----
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
-
N
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
G
Q
------
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
--
R
R
-
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
-
K
-
G
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
--
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
-----
R
D
-
E
-
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
E
W
K
F
D
T
L
C
D
L
Y
D
T
-
L
T
I
T
Q
-
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
-
D
-
I
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
M
P
M
N
V
A
D
L
I
L
E
--------------------------------------------------------------------------------
8
PsiBlast_PDB
85.59
35%
-120
- C4 -
2J0U
1
IF4A3_HUMAN
A:
[2-356]
----
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
V
S
V
---
L
Q
C
L
--------------
D
I
-
Q
------------------
V
-----
R
-----
E
T
---
Q
----
A
L
I
L
A
P
T
R
E
L
A
V
Q
V
Q
K
G
L
L
A
L
G
D
Y
M
-
N
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
G
Q
------
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
--
R
R
-
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
-
K
-
G
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
--
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
-----
R
D
-
E
-
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
E
W
K
F
D
T
L
C
D
L
Y
D
----
I
T
Q
-
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
--
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
V
N
F
V
K
N
D
-
D
-
I
R
V
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
M
P
M
N
V
A
-------------------------------------------------------------------------------------
16
PsiBlast_PDB
85.39
35%
-108
- C4 -
4D26
4
?
A:
[51-404]
----
S
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
G
--
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
---
I
N
M
L
L
Q
------------
D
P
-
K
------------------
D
-----
L
I
S
E
N-
G
C
A
Q
P
Q
----
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
G
S
-
V
L
K
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
I
-
A
R
G
C
------
H
I
L
V
A
T
P
G
R
L
H
D
F
V
E
--
R
N
-
R
V
S
F
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
D
-
M
-
G
F
M
P
S
I
E
K
M
M
L
H
PTMV
E
----
T
--
T
K
--
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
-----
I
V
-
G
G
A
S
T
D
-
V
E
Q
I
F
I
E
V
T
K
-
Y
E
-
K
R
N
S
L
K
Q
L
I
E
E
-
N
D
G
K
R
-
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
------
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
S
D
-
Q
-
D
L
A
L
V
A
D
L
S
K
I
L
R
Q
A
D
Q
S
V
P
D
F
L
K
------------------------------------------------------------------------------------
26
PsiBlast_CBE
85.21
32%
-122
- C4 -
4CT4
2
DDX6_HUMAN
D:
[7-360]
-----
F
E
D
Y
C
L
K
R
E
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
S
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
---
L
E
R
L
--------------
D
L
-
K
------------------
K
-----
D
-----
N
I
---
Q
----
A
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
Q
V
S
K
H
M
G
G
A
K
V
M
A
T
T
G
G
T
N
L
R
D
D
I
M
R
L
-
D
D
T
V
------
H
V
V
I
A
T
P
G
R
I
L
D
L
I
K
--
K
G
-
V
A
K
V
D
H
V
Q
M
I
V
L
D
E
A
D
K
L
L
S
-
Q
-
D
F
V
Q
I
M
E
D
I
I
L
T
----
L
----
P
--
K
N
--
R
Q
I
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
K
P
Y
E
I
N
L
M
-----
E
E
-
L
-
T
L
K
G
-
V
T
Q
Y
Y
A
Y
V
T
E
-
R
Q
-
K
V
H
C
L
N
T
L
F
S
R
-
L
Q
I
N
Q
-
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
Q
L
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
----
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
L
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
T
Y
D
-
D
-
R
F
N
L
K
S
I
E
E
Q
L
G
T
E
I
K
P
I
P
S
----------------------------------------------------------------------------------------
107
HHSearch
83.07
32%
-114
- C4 -
3FHT
4
DD19B_HUMAN
A:
[24-399]
--
V
K
S
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
---
L
S
Q
V
--------------
E
P
-
A
------------------
N
-----
K
-----
Y
P
---
Q
----
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
P
E
L
K
L
A
Y
A
V
R
G
N
K
L
---
E
R
G
Q
-
K
I
S
E
------
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
S
--
K
L
K
F
I
D
P
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A
-
T
Q
G
H
Q
D
Q
S
I
R
I
Q
R
M
----
L
----
P
--
R
N
--
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
-----
R
E
E
E
-
T
L
D
T
-
I
K
Q
Y
Y
V
L
C
S
S
R
D
E
-
K
F
Q
A
L
C
N
L
Y
G
A
-
I
T
I
A
Q
-
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
DKDGNP
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
-
H
S
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
------------------------------------------------------------------------------------------
64
PsiBlast_CBE
70.95
39%
-127
- C4 -
3FE2
4
DDX5_HUMAN
B:
[31-239]
-----
F
Y
E
A
N
F
P
A
N
V
M
D
V
I
A
R
Q
N
F
T
E
P
T
A
I
Q
A
Q
G
W
P
V
A
L
S
G
--
L
D
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
L
P
A
---
I
V
H
I
--------------
N
H
-
Q
------------------
P
-----
F
LERGD
G
P
---
I
----
C
L
V
L
A
P
T
R
E
L
A
Q
Q
V
Q
Q
V
A
A
E
Y
C
R
A
C
-
R
L
K
S
T
C
I
Y
G
G
A
P
K
G
P
Q
I
R
D
L
-
E
R
G
V
------
E
I
C
I
A
T
P
G
R
L
I
D
F
L
E
--
C
G
-
K
T
N
L
R
R
T
T
Y
L
V
L
D
E
A
D
R
M
L
D
-
M
-
G
F
E
P
Q
I
R
K
I
V
D
Q
----
I
----
R
--
P
D
--
R
Q
T
L
M
W
S
A
T
W
P
K
E
V
R
Q
L
A
E
D
F
L
K
D
Y
I
H
I
N
I
G
-----
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
70.82
39%
-128
- C4 -
3FE2
3
DDX5_HUMAN
A:
[31-239]
-----
F
Y
E
A
N
F
P
A
N
V
M
D
V
I
A
R
Q
N
F
T
E
P
T
A
I
Q
A
Q
G
W
P
V
A
L
S
G
--
L
D
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
L
P
A
---
I
V
H
I
--------------
N
H
-
Q
------------------
P
-----
F
LERGD
G
P
---
I
----
C
L
V
L
A
P
T
R
E
L
A
Q
Q
V
Q
Q
V
A
A
E
Y
C
R
A
C
-
R
L
K
S
T
C
I
Y
G
G
A
P
K
G
P
Q
I
R
D
L
-
E
R
G
V
------
E
I
C
I
A
T
P
G
R
L
I
D
F
L
E
--
C
G
-
K
T
N
L
R
R
T
T
Y
L
V
L
D
E
A
D
R
M
L
D
-
M
-
G
F
E
P
Q
I
R
K
I
V
D
Q
----
I
----
R
--
P
D
--
R
Q
T
L
M
W
S
A
T
W
P
K
E
V
R
Q
L
A
E
D
F
L
K
D
Y
I
H
I
N
I
G
-----
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
70.63
46%
-128
- C4 -
3NBF
4
?
C:
[3-205]
-----
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
AER
L
A
P
S
--------------
Q
E
-
R
------------------
G
-----
R
-----
K
P
---
R
----
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
---
L
T
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
------
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
--
Q
G
-
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
-
M
-
G
F
E
E
E
V
E
A
L
L
S
A
----
T
----
P
--
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
-----
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
70.13
46%
-134
- C4 -
3NBF
2
?
D:
[3-205]
-----
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
----
G
K
T
L
A
F
A
L
P
I
AER
L
A
P
S
--------------
Q
E
-
R
------------------
G
-----
R
-----
K
P
---
R
----
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
---
L
T
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
------
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
--
Q
G
-
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
-
M
-
G
F
E
E
E
V
E
A
L
L
S
A
----
T
----
P
--
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
69.91
46%
-131
- C4 -
3MWL
2
?
B:
[3-205]
-----
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
AER
L
A
P
S
--------------
Q
E
-
R
------------------
G
-----
R
-----
K
P
---
R
----
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
---
L
T
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
------
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
--
Q
G
-
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
-
M
-
G
F
E
E
E
V
E
A
L
L
S
A
----
T
----
P
--
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
-----
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
69.64
46%
-125
- C4 -
2GXQ
2
?
A:
[3-205]
-----
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
A
P
S
--------------
Q
E
-
R
------------------
G
-----
R
-----
K
P
---
R
----
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
---
L
T
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
------
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
--
Q
G
-
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
-
M
-
G
F
E
E
E
V
E
A
L
L
S
A
----
T
----
P
--
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
-----
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
69.41
46%
-128
- C4 -
2GXS
3
?
A:
[3-205]
-----
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
A
P
S
--------------
Q
E
-
R
------------------
G
-----
R
-----
K
P
---
R
----
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
---
L
T
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
------
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
--
Q
G
-
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
-
M
-
G
F
E
E
E
V
E
A
L
L
S
A
----
T
----
P
--
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
-----
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
69.40
46%
-121
- C4 -
3NBF
2
?
A:
[3-205]
-----
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
A
P
S
--------------
Q
E
-
R
------------------
G
-----
R
-----
K
P
---
R
----
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
---
L
T
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
------
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
--
Q
G
-
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
-
M
-
G
F
E
E
E
V
E
A
L
L
S
A
----
T
----
P
--
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
-----
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
69.40
46%
-122
- C4 -
3NBF
2
?
B:
[3-205]
-----
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
A
P
S
--------------
Q
E
-
R
------------------
G
-----
R
-----
K
P
---
R
----
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
---
L
T
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
------
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
--
Q
G
-
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
-
M
-
G
F
E
E
E
V
E
A
L
L
S
A
----
T
----
P
--
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
-----
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
69.21
46%
-126
- C4 -
3MWK
2
?
B:
[3-205]
-----
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
AER
L
A
P
S
--------------
Q
E
-
R
------------------
G
-----
R
-----
K
P
---
R
----
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
---
L
T
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
------
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
--
Q
G
-
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
-
M
-
G
F
E
E
E
V
E
A
L
L
S
A
----
T
----
P
--
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
-----
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
69.04
46%
-128
- C4 -
2GXS
4
?
B:
[3-205]
-----
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
AER
L
A
P
S
--------------
Q
E
-
R
------------------
G
-----
R
-----
K
P
---
R
----
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
---
L
T
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
------
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
--
Q
G
-
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
-
M
-
G
F
E
E
E
V
E
A
L
L
S
A
----
T
----
P
--
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
-----
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
68.49
38%
-134
- C4 -
4PX9
1
DDX3X_HUMAN
C:
[66-282]
----
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
---
L
S
Q
I
YSDGPGEALRAMKE
N
G
-
R
------------------
Y
-----
G
-----
R
R
---
K
QYPI
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
R
S
-
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
------
H
L
L
V
A
T
P
G
R
L
V
D
M
M
E
--
R
G
-
K
I
G
L
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
D
-
M
-
G
F
E
P
Q
I
R
R
I
V
E
Q
DT--
M
----
P
--
P
K
GV
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
-----
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
68.28
38%
-125
- C4 -
3BER
4
DDX47_HUMAN
A:
[42-249]
--
T
K
T
F
K
D
L
G
V
T
D
V
L
C
E
A
C
D
Q
L
G
W
T
K
P
T
K
I
Q
I
E
A
I
P
L
A
L
Q
G
--
R
D
I
I
G
L
A
E
T
G
S
G
K
T
G
A
F
A
L
P
I
---
L
N
A
L
L
E
------------
T
P
Q
R
------------------
L
-----
F
---------------
A
L
V
L
T
P
T
R
E
L
A
F
Q
I
S
E
Q
F
E
A
L
G
S
S
I
-
G
V
Q
S
A
V
I
V
G
G
I
D
S
M
S
Q
S
L
A
L
-
A
K
K
P
------
H
I
I
I
A
T
P
G
R
L
I
D
H
L
E
NT
K
G
--
F
N
L
R
A
L
K
Y
L
V
M
D
E
A
D
R
I
L
N
-
M
-
D
F
E
T
E
V
D
K
I
L
K
V
----
I
----
P
--
R
D
--
R
K
T
F
L
F
S
A
T
M
T
K
K
V
Q
K
L
Q
R
A
A
L
K
N
P
V
K
C
A
V
S
-----
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
66.79
35%
-116
- C4 -
1T6N
1
DX39B_HUMAN
A:
[14-220]
---
S
G
F
R
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
L
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
---
L
Q
Q
L
--------------
E
P
-
V
------------------
T
-----
G
-----
Q
V
---
S
----
V
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
K
Y
M
P
N
V
K
V
A
V
F
F
G
G
L
S
I
K
K
D
E
E
V
L
-
K
K
N
C
P-----
H
I
V
V
G
T
P
G
R
I
L
A
L
A
R
--
N
K
-
S
L
N
L
K
H
I
K
H
F
I
L
D
E
C
D
K
M
L
E
Q
L
-
D
M
R
R
D
V
Q
E
I
F
R
M
----
T
----
P
--
H
E
--
K
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
M
E
I
F
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
65.88
35%
-115
- C4 -
1T6N
1
DX39B_HUMAN
B:
[14-220]
---
S
G
F
R
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
L
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
---
L
Q
Q
L
--------------
E
P
-
V
------------------
T
-----
G
-----
Q
V
---
S
----
V
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
K
Y
M
P
N
V
K
V
A
V
F
F
G
G
L
S
I
K
K
D
E
E
V
L
-
K
K
N
C
P-----
H
I
V
V
G
T
P
G
R
I
L
A
L
A
R
--
N
K
-
S
L
N
L
K
H
I
K
H
F
I
L
D
E
C
D
K
M
L
E
Q
L
-
D
M
R
R
D
V
Q
E
I
F
R
M
----
T
----
P
--
H
E
--
K
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
M
E
I
F
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
64.92
39%
-117
- C4 -
2PL3
6
DDX10_HUMAN
A:
[25-232]
---
T
R
F
S
D
F
P
L
S
K
K
T
L
K
G
L
Q
E
A
Q
Y
R
L
V
T
E
I
Q
K
Q
T
I
G
L
A
L
Q
G
--
K
D
V
L
G
A
A
K
T
G
S
G
K
T
L
A
F
L
V
P
V
---
L
E
A
L
--------------
Y
R
-
L
------------------
Q
-----
W
TSTD-
G
L
---
G
----
V
L
I
I
S
P
T
R
E
L
A
Y
Q
T
F
E
V
L
R
K
V
G
K
N
H
D
------
F
S
A
G
L
I
I
G
G
----
L
-
K
H
E
A
E
R
I
N
NI
N
I
L
V
C
T
P
G
R
L
L
Q
H
M
D
--
E
T
V
S
F
H
A
T
D
L
Q
M
L
V
L
D
E
A
D
R
I
L
D
-
M
-
G
F
A
D
T
M
N
A
V
I
E
N
----
L
----
P
--
K
K
--
R
Q
T
L
L
F
S
A
T
Q
T
K
S
V
K
D
L
A
R
L
S
L
K
N
P
E
Y
V
W
V
H
-----
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------