@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0551: (2016-01-09 )
MSTPPFRVALNGYGRIGRCVLRALHERPEQLGFEIVALNDLADQASVEYLTRFDSTHGRFPGEVKVDGDCLHINGDCVKVLRSPTPEAIDWQALRVDLVLECSGQYTNRAQAERFLRAGAPRVLFSQPMASEADIDATIVYGVNQQDLSGRETLVSNASCTTNCGVPLLKLLNEAIGLEYVSITTIHSAMNDQPVIDAYHHEDLRRTRSAFQSVIPVSTGLARGIERLLPELAGRIQAKAIRVPTVNVSALDITLQTSRDTSAAEINRVLREAAESGPLRGLLAYTELPHASCDFNHDPHSAIVDGSQTRVSGPRLVNLLAWFDNEWGFANRMLDVAGHYLRAAVPDQQVPKD
Atome Classification :
(28 SA)
.........10........20.....--...30........40........50........60-......-..70........80........90........100.......110.......120.......130.......140.......-150........160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260........270....------...280.......290.......300.......310.......320.......330.......340.......350.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSTP
P
F
R
V
A
LNGY
G
R
I
G
R
C
V
L
R
A
L
H
E--
R
P
E
QLG
F
E
I
V
A
LNDLA
D
Q
A
S
V
E
Y
L
T
R
FDSTHGRFP-G
E
V
K
VD-G
D
C
L
H
IN
G
D
C
V
K
V
LRSPTPEAID
W
Q
A
L
R
V
D
L
V
L
ECSGQYT
N
R
A
Q
A
E
R
F
L
R
AGA
P
R
V
L
FSQPMASEADI
D
A
T
I
V
Y
GVNQQDLS-G-
R
E
T
L
VSNASCTTNCG
V
P
L
L
K
L
L
N
E
AIG
L
E
Y
V
S
I
T
T
I
H
S
AMNDQPV
I
D
A
Y
H
H
E
D
L
R
R
T
R
S
A
F
Q
S
VIPV
S
T
G
L
A
R
G
I
E
R
L
L
P
E
L
A
G
R
I
Q
A
K
A
I
RV
P
T
V
N
V
S
A
L
D
I
T
L
QTSRD-T
S
A
A
E
I
N
R
V
L
R
E
A
A
ES------GPL
R
G
L
L
A
YTELPHASCDFNHDPHSAIVDGSQTRVSGPR
L
V
N
L
L
A
W
FDNEW
G
F
A
N
R
M
L
D
V
A
G
H
Y
L
R
AAVPDQQVPKD
30
PsiBlast_CBE
94.57
53%
-117
- C3 -
2XF8
1
E4PD_ECOLI
H:
[3-327]
------
R
V
A
I
N
G
F
G
R
I
G
R
N
V
V
R
A
L
Y
E
--
S
G
R
R
A
E
I
T
V
V
A
I
N
E
L
A
D
A
A
G
M
A
H
L
L
K
Y
D
T
S
H
G
R
F
A
-
W
E
V
R
Q
E
-
R
D
Q
L
F
V
G
D
D
A
I
R
V
L
H
E
R
S
L
Q
S
L
P
W
R
E
L
G
V
D
V
V
L
D
C
T
G
V
Y
G
S
R
E
H
G
E
A
H
I
A
A
G
A
K
K
V
L
F
S
H
P
G
S
N
--
D
L
D
A
T
V
V
Y
G
V
N
Q
D
Q
L
R
-
A
-
E
H
R
I
V
S
N
A
S
C
T
T
N
C
I
I
P
V
I
K
L
L
D
D
A
Y
G
I
E
S
G
T
V
T
T
I
H
S
A
-------------------
A
A
S
Q
S
I
I
P
V
D
T
K
L
A
A
G
I
T
R
F
F
P
Q
F
N
D
R
F
E
A
I
A
V
R
V
P
T
I
N
V
T
A
I
D
L
S
V
T
V
K
K
P
-
V
K
A
N
E
V
N
L
L
L
Q
K
A
A
Q
-------
G
A
F
H
G
I
V
D
Y
T
E
L
P
L
V
S
V
D
F
N
H
D
P
H
S
A
I
V
D
G
T
Q
T
R
V
S
G
A
H
L
I
K
T
L
V
W
C
D
N
E
W
G
F
A
N
R
M
L
D
T
T
L
A
M
A
T
V
----------
119
HHSearch
94.27
52%
-119
- C3 -
2X5J
1
E4PD_ECOLI
O:
[2-336]
----
T
V
R
V
A
I
N
G
F
G
R
I
G
R
N
V
V
R
A
L
Y
E
--
S
G
R
R
A
E
I
T
V
V
A
I
N
E
L
A
D
A
A
G
M
A
H
L
L
K
Y
D
T
S
H
G
R
F
A
-
W
E
V
R
Q
E
-
R
D
Q
L
F
V
G
D
D
A
I
R
V
L
H
E
R
S
L
Q
S
L
P
W
R
E
L
G
V
D
V
V
L
D
C
T
G
V
Y
G
S
R
E
H
G
E
A
H
I
A
A
G
A
K
K
V
L
F
S
H
P
G
S
N
--
D
L
D
A
T
V
V
Y
G
V
N
Q
D
Q
L
R
-
A
-
E
H
R
I
V
S
N
A
S
C
T
T
N
C
I
I
P
V
I
K
L
L
D
D
A
Y
G
I
E
S
G
T
V
T
T
I
H
S
A
M
------------
D
L
R
R
T
R
A
A
S
Q
S
I
I
P
V
D
T
K
L
A
A
G
I
T
R
F
F
P
Q
F
N
D
R
F
E
A
I
A
V
R
V
P
T
I
N
V
T
A
I
D
L
S
V
T
V
K
K
P
-
V
K
A
N
E
V
N
L
L
L
Q
K
A
A
-
Q
------
G
A
F
H
G
I
V
D
Y
T
E
L
P
L
V
S
V
D
F
N
H
D
P
H
S
A
I
V
D
G
T
Q
T
R
V
S
G
A
H
L
I
K
T
L
V
W
C
D
N
E
W
G
F
A
N
R
M
L
D
T
T
L
A
M
A
T
V
----------
32
PsiBlast_CBE
94.17
53%
-113
- C3 -
2XF8
1
E4PD_ECOLI
F:
[3-327]
------
R
V
A
I
N
G
F
G
R
I
G
R
N
V
V
R
A
L
Y
E
--
S
G
R
R
A
E
I
T
V
V
A
I
N
E
L
A
D
A
A
G
M
A
H
L
L
K
Y
D
T
S
H
G
R
F
A
-
W
E
V
R
Q
E
-
R
D
Q
L
F
V
G
D
D
A
I
R
V
L
H
E
R
S
L
Q
S
L
P
W
R
E
L
G
V
D
V
V
L
D
C
T
G
V
Y
G
S
R
E
H
G
E
A
H
I
A
A
G
A
K
K
V
L
F
S
H
P
G
S
N
--
D
L
D
A
T
V
V
Y
G
V
N
Q
D
Q
L
R
-
A
-
E
H
R
I
V
S
N
A
S
C
T
T
N
C
I
I
P
V
I
K
L
L
D
D
A
Y
G
I
E
S
G
T
V
T
T
I
H
S
A
-------------
D
L
R
R
T
R
A
A
S
Q
S
I
I
P
V
D
T
K
L
A
A
G
I
T
R
F
F
P
Q
F
N
D
R
F
E
A
I
A
V
R
V
P
T
I
N
V
T
A
I
D
L
S
V
T
V
K
K
P
-
V
K
A
N
E
V
N
L
L
L
Q
K
A
A
Q
-------
G
A
F
H
G
I
V
D
Y
T
E
L
P
L
V
S
V
D
F
N
H
D
P
H
S
A
I
V
D
G
T
Q
T
R
V
S
G
A
H
L
I
K
T
L
V
W
C
D
N
E
W
G
F
A
N
R
M
L
D
T
T
L
A
M
A
T
V
A
F
R
-------
31
PsiBlast_CBE
94.01
53%
-110
- C3 -
2XF8
1
E4PD_ECOLI
G:
[3-327]
------
R
V
A
I
N
G
F
G
R
I
G
R
N
V
V
R
A
L
Y
E
--
S
G
R
R
A
E
I
T
V
V
A
I
N
E
L
A
D
A
A
G
M
A
H
L
L
K
Y
D
T
S
H
G
R
F
A
-
W
E
V
R
Q
E
-
R
D
Q
L
F
V
G
D
D
A
I
R
V
L
H
E
R
S
L
Q
S
L
P
W
R
E
L
G
V
D
V
V
L
D
C
T
G
V
Y
G
S
R
E
H
G
E
A
H
I
A
A
G
A
K
K
V
L
F
S
H
P
G
S
N
--
D
L
D
A
T
V
V
Y
G
V
N
Q
D
Q
L
R
-
A
-
E
H
R
I
V
S
N
A
S
C
T
T
N
C
I
I
P
V
I
K
L
L
D
D
A
Y
G
I
E
S
G
T
V
T
T
I
H
S
A
------------
P
D
L
R
R
T
R
A
A
S
Q
S
I
I
P
V
D
T
K
L
A
A
G
I
T
R
F
F
P
Q
F
N
D
R
F
E
A
I
A
V
R
V
P
T
I
N
V
T
A
I
D
L
S
V
T
V
K
K
P
-
V
K
A
N
E
V
N
L
L
L
Q
K
A
A
Q
-------
G
A
F
H
G
I
V
D
Y
T
E
L
P
L
V
S
V
D
F
N
H
D
P
H
S
A
I
V
D
G
T
Q
T
R
V
S
G
A
H
L
I
K
T
L
V
W
C
D
N
E
W
G
F
A
N
R
M
L
D
T
T
L
A
M
A
T
V
----------
42
PsiBlast_CBE
92.37
52%
-107
- C3 -
3GNQ
1
?
B:
[11-337]
-----
I
R
V
A
I
N
G
Y
G
R
I
G
R
N
T
L
R
A
F
Y
E
--
N
G
K
K
H
D
L
E
I
V
A
I
N
D
L
G
D
A
K
T
N
A
H
L
T
Q
Y
D
T
A
H
G
K
F
P
-
G
E
V
S
V
D
-
G
D
Y
L
V
V
N
G
D
R
I
R
V
L
A
N
R
N
P
A
E
L
P
W
G
E
L
G
V
D
V
V
M
E
C
T
G
F
F
T
S
K
E
K
A
S
A
H
L
K
G
G
A
K
K
V
I
I
S
A
P
G
G
K
--
D
V
D
A
T
I
V
Y
G
V
N
H
D
V
L
K
-
A
-
E
H
T
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
V
K
P
L
N
D
K
I
G
L
E
T
G
L
M
T
T
I
H
A
Y
T
N
D
Q
V
L
T
D
V
Y
-
H
E
D
L
R
R
A
R
S
A
T
H
S
Q
I
P
T
K
T
G
A
A
A
A
V
G
L
V
L
P
E
L
N
G
K
L
D
G
Y
A
I
R
V
P
T
I
N
V
S
I
V
D
L
S
F
I
A
K
R
D
-
T
T
A
A
E
V
N
A
I
M
K
E
A
S
E
-------
G
A
L
K
G
I
L
G
Y
N
E
A
P
L
V
S
I
D
F
N
H
N
P
A
S
S
T
F
D
A
T
L
T
K
V
S
G
-
R
L
V
K
V
S
S
W
Y
D
N
E
W
G
F
S
N
R
M
L
D
T
A
I
A
L
A
N
A
----------
34
PsiBlast_CBE
92.24
53%
-114
- C3 -
2XF8
1
E4PD_ECOLI
D:
[3-327]
------
R
V
A
I
N
G
F
G
R
I
G
R
N
V
V
R
A
L
Y
E
--
S
G
R
R
A
E
I
T
V
V
A
I
N
E
L
A
D
A
A
G
M
A
H
L
L
K
Y
D
T
S
H
G
R
F
A
-
W
E
V
R
Q
E
-
R
D
Q
L
F
V
G
D
D
A
I
R
V
L
H
E
R
S
L
Q
S
L
P
W
R
E
L
G
V
D
V
V
L
D
C
T
G
V
Y
G
S
R
E
H
G
E
A
H
I
A
A
G
A
K
K
V
L
F
S
H
P
G
S
N
--
D
L
D
A
T
V
V
Y
G
V
N
Q
D
Q
L
R
-
A
-
E
H
R
I
V
S
N
A
S
C
T
T
N
C
I
I
P
V
I
K
L
L
D
D
A
Y
G
I
E
S
G
T
V
T
T
I
H
S
A
-------------------
A
A
S
Q
S
I
I
P
V
D
T
K
L
A
A
G
I
T
R
F
F
P
Q
F
N
D
R
F
E
A
I
A
V
R
V
P
T
I
N
V
T
A
I
D
L
S
V
T
V
K
K
P
-
V
K
A
N
E
V
N
L
L
L
Q
K
A
A
Q
-------
G
A
F
H
G
I
V
D
Y
T
E
L
P
L
V
S
V
D
F
N
H
D
P
H
S
A
I
V
D
G
T
Q
T
R
V
S
G
A
H
L
I
K
T
L
V
W
C
D
N
E
W
G
F
A
N
R
M
L
D
T
T
L
A
M
A
T
V
----------
1
PsiBlast_PDB
92.18
53%
-117
- C3 -
2X5J
1
E4PD_ECOLI
O:
[4-328]
------
R
V
A
I
N
G
F
G
R
I
G
R
N
V
V
R
A
L
Y
E
--
S
G
R
R
A
E
I
T
V
V
A
I
N
E
L
A
D
A
A
G
M
A
H
L
L
K
Y
D
T
S
H
G
R
F
A
-
W
E
V
R
Q
E
-
R
D
Q
L
F
V
G
D
D
A
I
R
V
L
H
E
R
S
L
Q
S
L
P
W
R
E
L
G
V
D
V
V
L
D
C
T
G
V
Y
G
S
R
E
H
G
E
A
H
I
A
A
G
A
K
K
V
L
F
S
H
P
G
S
N
--
D
L
D
A
T
V
V
Y
G
V
N
Q
D
Q
L
R
-
A
-
E
H
R
I
V
S
N
A
S
C
T
T
N
C
I
I
P
V
I
K
L
L
D
D
A
Y
G
I
E
S
G
T
V
T
T
I
H
S
A
M
------------
D
L
R
R
T
R
A
A
S
Q
S
I
I
P
V
D
T
K
L
A
A
G
I
T
R
F
F
P
Q
F
N
D
R
F
E
A
I
A
V
R
V
P
T
I
N
V
T
A
I
D
L
S
V
T
V
K
K
P
-
V
K
A
N
E
V
N
L
L
L
Q
K
A
A
Q
-------
G
A
F
H
G
I
V
D
Y
T
E
L
P
L
V
S
V
D
F
N
H
D
P
H
S
A
I
V
D
G
T
Q
T
R
V
S
G
A
H
L
I
K
T
L
V
W
C
D
N
E
W
G
F
A
N
R
M
L
D
T
T
L
A
M
A
T
V
----------
38
PsiBlast_CBE
92.13
52%
-107
- C3 -
3GNQ
2
?
F:
[11-337]
-----
I
R
V
A
I
N
G
Y
G
R
I
G
R
N
T
L
R
A
F
Y
E
--
N
G
K
K
H
D
L
E
I
V
A
I
N
D
L
G
D
A
K
T
N
A
H
L
T
Q
Y
D
T
A
H
G
K
F
P
-
G
E
V
S
V
D
-
G
D
Y
L
V
V
N
G
D
R
I
R
V
L
A
N
R
N
P
A
E
L
P
W
G
E
L
G
V
D
V
V
M
E
C
T
G
F
F
T
S
K
E
K
A
S
A
H
L
K
G
G
A
K
K
V
I
I
S
A
P
G
G
K
--
D
V
D
A
T
I
V
Y
G
V
N
H
D
V
L
K
-
A
-
E
H
T
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
V
K
P
L
N
D
K
I
G
L
E
T
G
L
M
T
T
I
H
A
Y
T
N
D
Q
V
L
T
D
V
Y
-
H
E
D
L
R
R
A
R
S
A
T
H
S
Q
I
P
T
K
T
G
A
A
A
A
V
G
L
V
L
P
E
L
N
G
K
L
D
G
Y
A
I
R
V
P
T
I
N
V
S
I
V
D
L
S
F
I
A
K
R
D
-
T
T
A
A
E
V
N
A
I
M
K
E
A
S
E
-------
G
A
L
K
G
I
L
G
Y
N
E
A
P
L
V
S
I
D
F
N
H
N
P
A
S
S
T
F
D
A
T
L
T
K
V
S
G
-
R
L
V
K
V
S
S
W
Y
D
N
E
W
G
F
S
N
R
M
L
D
T
A
I
A
L
A
N
A
K
---------
36
PsiBlast_CBE
92.06
52%
-107
- C3 -
3GNQ
2
?
H:
[11-337]
-----
I
R
V
A
I
N
G
Y
G
R
I
G
R
N
T
L
R
A
F
Y
E
--
N
G
K
K
H
D
L
E
I
V
A
I
N
D
L
G
D
A
K
T
N
A
H
L
T
Q
Y
D
T
A
H
G
K
F
P
-
G
E
V
S
V
D
-
G
D
Y
L
V
V
N
G
D
R
I
R
V
L
A
N
R
N
P
A
E
L
P
W
G
E
L
G
V
D
V
V
M
E
C
T
G
F
F
T
S
K
E
K
A
S
A
H
L
K
G
G
A
K
K
V
I
I
S
A
P
G
G
K
--
D
V
D
A
T
I
V
Y
G
V
N
H
D
V
L
K
-
A
-
E
H
T
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
V
K
P
L
N
D
K
I
G
L
E
T
G
L
M
T
T
I
H
A
Y
T
N
D
Q
V
L
T
D
V
Y
-
H
E
D
L
R
R
A
R
S
A
T
H
S
Q
I
P
T
K
T
G
A
A
A
A
V
G
L
V
L
P
E
L
N
G
K
L
D
G
Y
A
I
R
V
P
T
I
N
V
S
I
V
D
L
S
F
I
A
K
R
D
-
T
T
A
A
E
V
N
A
I
M
K
E
A
S
E
-------
G
A
L
K
G
I
L
G
Y
N
E
A
P
L
V
S
I
D
F
N
H
N
P
A
S
S
T
F
D
A
T
L
T
K
V
S
G
-
R
L
V
K
V
S
S
W
Y
D
N
E
W
G
F
S
N
R
M
L
D
T
A
I
A
L
A
N
A
K
---------
24
PsiBlast_CBE
91.87
53%
-114
- C3 -
2XF8
14
E4PD_ECOLI
P:
[3-327]
------
R
V
A
I
N
G
F
G
R
I
G
R
N
V
V
R
A
L
Y
E
--
S
G
R
R
A
E
I
T
V
V
A
I
N
E
L
A
D
A
A
G
M
A
H
L
L
K
Y
D
T
S
H
G
R
F
A
-
W
E
V
R
Q
E
-
R
D
Q
L
F
V
G
D
D
A
I
R
V
L
H
E
R
S
L
Q
S
L
P
W
R
E
L
G
V
D
V
V
L
D
C
T
G
V
Y
G
S
R
E
H
G
E
A
H
I
A
A
G
A
K
K
V
L
F
S
H
P
G
S
N
--
D
L
D
A
T
V
V
Y
G
V
N
Q
D
Q
L
R
-
A
-
E
H
R
I
V
S
N
A
S
C
T
T
N
C
I
I
P
V
I
K
L
L
D
D
A
Y
G
I
E
S
G
T
V
T
T
I
H
S
A
-------------------
A
A
S
Q
S
I
I
P
V
D
T
K
L
A
A
G
I
T
R
F
F
P
Q
F
N
D
R
F
E
A
I
A
V
R
V
P
T
I
N
V
T
A
I
D
L
S
V
T
V
K
K
P
-
V
K
A
N
E
V
N
L
L
L
Q
K
A
A
Q
-------
G
A
F
H
G
I
V
D
Y
T
E
L
P
L
V
S
V
D
F
N
H
D
P
H
S
A
I
V
D
G
T
Q
T
R
V
S
G
A
H
L
I
K
T
L
V
W
C
D
N
E
W
G
F
A
N
R
M
L
D
T
T
L
A
M
A
T
V
----------
23
PsiBlast_CBE
91.87
53%
-109
- C3 -
2X5J
1
E4PD_ECOLI
P:
[4-328]
------
R
V
A
I
N
G
F
G
R
I
G
R
N
V
V
R
A
L
Y
E
--
S
G
R
R
A
E
I
T
V
V
A
I
N
E
L
A
D
A
A
G
M
A
H
L
L
K
Y
D
T
S
H
G
R
F
A
-
W
E
V
R
Q
E
-
R
D
Q
L
F
V
G
D
D
A
I
R
V
L
H
E
R
S
L
Q
S
L
P
W
R
E
L
G
V
D
V
V
L
D
C
T
G
V
Y
G
S
R
E
H
G
E
A
H
I
A
A
G
A
K
K
V
L
F
S
H
P
G
S
N
--
D
L
D
A
T
V
V
Y
G
V
N
Q
D
Q
L
R
-
A
-
E
H
R
I
V
S
N
A
S
C
T
T
N
C
I
I
P
V
I
K
L
L
D
D
A
Y
G
I
E
S
G
T
V
T
T
I
H
S
A
M
H
---------
H
P
D
L
R
R
T
R
A
A
S
Q
S
I
I
P
V
D
T
K
L
A
A
G
I
T
R
F
F
P
Q
F
N
D
R
F
E
A
I
A
V
R
V
P
T
I
N
V
T
A
I
D
L
S
V
T
V
K
K
P
-
V
K
A
N
E
V
N
L
L
L
Q
K
A
A
Q
-------
G
A
F
H
G
I
V
D
Y
T
E
L
P
L
V
S
V
D
F
N
H
D
P
H
S
A
I
V
D
G
T
Q
T
R
V
S
G
A
H
L
I
K
T
L
V
W
C
D
N
E
W
G
F
A
N
R
M
L
D
T
T
L
A
M
A
T
V
A
---------
2
PsiBlast_PDB
91.77
53%
-110
- C3 -
2XF8
2
E4PD_ECOLI
A:
[3-327]
------
R
V
A
I
N
G
F
G
R
I
G
R
N
V
V
R
A
L
Y
E
--
S
G
R
R
A
E
I
T
V
V
A
I
N
E
L
A
D
A
A
G
M
A
H
L
L
K
Y
D
T
S
H
G
R
F
A
-
W
E
V
R
Q
E
-
R
D
Q
L
F
V
G
D
D
A
I
R
V
L
H
E
R
S
L
Q
S
L
P
W
R
E
L
G
V
D
V
V
L
D
C
T
G
V
Y
G
S
R
E
H
G
E
A
H
I
A
A
G
A
K
K
V
L
F
S
H
P
G
S
N
--
D
L
D
A
T
V
V
Y
G
V
N
Q
D
Q
L
R
-
A
-
E
H
R
I
V
S
N
A
S
C
T
T
N
C
I
I
P
V
I
K
L
L
D
D
A
Y
G
I
E
S
G
T
V
T
T
I
H
S
A
-----------
H
P
D
L
R
R
T
R
A
A
S
Q
S
I
I
P
V
D
T
K
L
A
A
G
I
T
R
F
F
P
Q
F
N
D
R
F
E
A
I
A
V
R
V
P
T
I
N
V
T
A
I
D
L
S
V
T
V
K
K
P
-
V
K
A
N
E
V
N
L
L
L
Q
K
A
A
Q
-------
G
A
F
H
G
I
V
D
Y
T
E
L
P
L
V
S
V
D
F
N
H
D
P
H
S
A
I
V
D
G
T
Q
T
R
V
S
G
A
H
L
I
K
T
L
V
W
C
D
N
E
W
G
F
A
N
R
M
L
D
T
T
L
A
M
A
T
V
A
---------
37
PsiBlast_CBE
91.75
52%
-105
- C3 -
3GNQ
2
?
G:
[11-337]
-----
I
R
V
A
I
N
G
Y
G
R
I
G
R
N
T
L
R
A
F
Y
E
--
N
G
K
K
H
D
L
E
I
V
A
I
N
D
L
G
D
A
K
T
N
A
H
L
T
Q
Y
D
T
A
H
G
K
F
P
-
G
E
V
S
V
D
-
G
D
Y
L
V
V
N
G
D
R
I
R
V
L
A
N
R
N
P
A
E
L
P
W
G
E
L
G
V
D
V
V
M
E
C
T
G
F
F
T
S
K
E
K
A
S
A
H
L
K
G
G
A
K
K
V
I
I
S
A
P
G
G
K
--
D
V
D
A
T
I
V
Y
G
V
N
H
D
V
L
K
-
A
-
E
H
T
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
V
K
P
L
N
D
K
I
G
L
E
T
G
L
M
T
T
I
H
A
Y
T
N
D
Q
V
L
T
D
V
Y
-
H
E
D
L
R
R
A
R
S
A
T
H
S
Q
I
P
T
K
T
G
A
A
A
A
V
G
L
V
L
P
E
L
N
G
K
L
D
G
Y
A
I
R
V
P
T
I
N
V
S
I
V
D
L
S
F
I
A
K
R
D
-
T
T
A
A
E
V
N
A
I
M
K
E
A
S
E
-------
G
A
L
K
G
I
L
G
Y
N
E
A
P
L
V
S
I
D
F
N
H
N
P
A
S
S
T
F
D
A
T
L
T
K
V
S
G
-
R
L
V
K
V
S
S
W
Y
D
N
E
W
G
F
S
N
R
M
L
D
T
A
I
A
L
A
N
A
K
---------
22
PsiBlast_CBE
91.29
53%
-108
- C3 -
2X5J
1
E4PD_ECOLI
Q:
[4-328]
------
R
V
A
I
N
G
F
G
R
I
G
R
N
V
V
R
A
L
Y
E
--
S
G
R
R
A
E
I
T
V
V
A
I
N
E
L
A
D
A
A
G
M
A
H
L
L
K
Y
D
T
S
H
G
R
F
A
-
W
E
V
R
Q
E
-
R
D
Q
L
F
V
G
D
D
A
I
R
V
L
H
E
R
S
L
Q
S
L
P
W
R
E
L
G
V
D
V
V
L
D
C
T
G
V
Y
G
S
R
E
H
G
E
A
H
I
A
A
G
A
K
K
V
L
F
S
H
P
G
S
N
--
D
L
D
A
T
V
V
Y
G
V
N
Q
D
Q
L
R
-
A
-
E
H
R
I
V
S
N
A
S
C
T
T
N
C
I
I
P
V
I
K
L
L
D
D
A
Y
G
I
E
S
G
T
V
T
T
I
H
S
A
M
H
----------
P
D
L
R
R
T
R
A
A
S
Q
S
I
I
P
V
D
T
K
L
A
A
G
I
T
R
F
F
P
Q
F
N
D
R
F
E
A
I
A
V
R
V
P
T
I
N
V
T
A
I
D
L
S
V
T
V
K
K
P
-
V
K
A
N
E
V
N
L
L
L
Q
K
A
A
Q
-------
G
A
F
H
G
I
V
D
Y
T
E
L
P
L
V
S
V
D
F
N
H
D
P
H
S
A
I
V
D
G
T
Q
T
R
V
S
G
A
H
L
I
K
T
L
V
W
C
D
N
E
W
G
F
A
N
R
M
L
D
T
T
L
A
M
A
T
V
A
F
--------
33
PsiBlast_CBE
91.24
53%
-112
- C3 -
2XF8
2
E4PD_ECOLI
E:
[3-327]
------
R
V
A
I
N
G
F
G
R
I
G
R
N
V
V
R
A
L
Y
E
--
S
G
R
R
A
E
I
T
V
V
A
I
N
E
L
A
D
A
A
G
M
A
H
L
L
K
Y
D
T
S
H
G
R
F
A
-
W
E
V
R
Q
E
-
R
D
Q
L
F
V
G
D
D
A
I
R
V
L
H
E
R
S
L
Q
S
L
P
W
R
E
L
G
V
D
V
V
L
D
C
T
G
V
Y
G
S
R
E
H
G
E
A
H
I
A
A
G
A
K
K
V
L
F
S
H
P
G
S
N
--
D
L
D
A
T
V
V
Y
G
V
N
Q
D
Q
L
R
-
A
-
E
H
R
I
V
S
N
A
S
C
T
T
N
C
I
I
P
V
I
K
L
L
D
D
A
Y
G
I
E
S
G
T
V
T
T
I
H
S
A
-----------
H
P
D
L
R
R
T
R
A
A
S
Q
S
I
I
P
V
D
T
K
L
A
A
G
I
T
R
F
F
P
Q
F
N
D
R
F
E
A
I
A
V
R
V
P
T
I
N
V
T
A
I
D
L
S
V
T
V
K
K
P
-
V
K
A
N
E
V
N
L
L
L
Q
K
A
A
Q
-------
G
A
F
H
G
I
V
D
Y
T
E
L
P
L
V
S
V
D
F
N
H
D
P
H
S
A
I
V
D
G
T
Q
T
R
V
S
G
A
H
L
I
K
T
L
V
W
C
D
N
E
W
G
F
A
N
R
M
L
D
T
T
L
A
M
A
T
V
----------
21
PsiBlast_CBE
91.13
53%
-112
- C3 -
2X5J
1
E4PD_ECOLI
R:
[4-328]
------
R
V
A
I
N
G
F
G
R
I
G
R
N
V
V
R
A
L
Y
E
--
S
G
R
R
A
E
I
T
V
V
A
I
N
E
L
A
D
A
A
G
M
A
H
L
L
K
Y
D
T
S
H
G
R
F
A
-
W
E
V
R
Q
E
-
R
D
Q
L
F
V
G
D
D
A
I
R
V
L
H
E
R
S
L
Q
S
L
P
W
R
E
L
G
V
D
V
V
L
D
C
T
G
V
Y
G
S
R
E
H
G
E
A
H
I
A
A
G
A
K
K
V
L
F
S
H
P
G
S
N
--
D
L
D
A
T
V
V
Y
G
V
N
Q
D
Q
L
R
-
A
-
E
H
R
I
V
S
N
A
S
C
T
T
N
C
I
I
P
V
I
K
L
L
D
D
A
Y
G
I
E
S
G
T
V
T
T
I
H
S
A
M
-------
A
Y
-
H
P
D
L
R
R
T
R
A
A
S
Q
S
I
I
P
V
D
T
K
L
A
A
G
I
T
R
F
F
P
Q
F
N
D
R
F
E
A
I
A
V
R
V
P
T
I
N
V
T
A
I
D
L
S
V
T
V
K
K
P
-
V
K
A
N
E
V
N
L
L
L
Q
K
A
A
Q
-------
G
A
F
H
G
I
V
D
Y
T
E
L
P
L
V
S
V
D
F
N
H
D
P
H
S
A
I
V
D
G
T
Q
T
R
V
S
G
A
H
L
I
K
T
L
V
W
C
D
N
E
W
G
F
A
N
R
M
L
D
T
T
L
A
M
A
T
V
A
F
--------
41
PsiBlast_CBE
90.95
52%
-106
- C3 -
3GNQ
2
?
C:
[11-337]
-----
I
R
V
A
I
N
G
Y
G
R
I
G
R
N
T
L
R
A
F
Y
E
--
N
G
K
K
H
D
L
E
I
V
A
I
N
D
L
G
D
A
K
T
N
A
H
L
T
Q
Y
D
T
A
H
G
K
F
P
-
G
E
V
S
V
D
-
G
D
Y
L
V
V
N
G
D
R
I
R
V
L
A
N
R
N
P
A
E
L
P
W
G
E
L
G
V
D
V
V
M
E
C
T
G
F
F
T
S
K
E
K
A
S
A
H
L
K
G
G
A
K
K
V
I
I
S
A
P
G
G
K
--
D
V
D
A
T
I
V
Y
G
V
N
H
D
V
L
K
-
A
-
E
H
T
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
V
K
P
L
N
D
K
I
G
L
E
T
G
L
M
T
T
I
H
A
Y
T
N
D
Q
V
L
T
D
V
Y
-
H
E
D
L
R
R
A
R
S
A
T
H
S
Q
I
P
T
K
T
G
A
A
A
A
V
G
L
V
L
P
E
L
N
G
K
L
D
G
Y
A
I
R
V
P
T
I
N
V
S
I
V
D
L
S
F
I
A
K
R
D
-
T
T
A
A
E
V
N
A
I
M
K
E
A
S
E
-------
G
A
L
K
G
I
L
G
Y
N
E
A
P
L
V
S
I
D
F
N
H
N
P
A
S
S
T
F
D
A
T
L
T
K
V
S
G
-
R
L
V
K
V
S
S
W
Y
D
N
E
W
G
F
S
N
R
M
L
D
T
A
I
A
L
A
N
A
K
---------
35
PsiBlast_CBE
90.49
53%
-111
- C3 -
2XF8
2
E4PD_ECOLI
C:
[3-327]
------
R
V
A
I
N
G
F
G
R
I
G
R
N
V
V
R
A
L
Y
E
--
S
G
R
R
A
E
I
T
V
V
A
I
N
E
L
A
D
A
A
G
M
A
H
L
L
K
Y
D
T
S
H
G
R
F
A
-
W
E
V
R
Q
E
-
R
D
Q
L
F
V
G
D
D
A
I
R
V
L
H
E
R
S
L
Q
S
L
P
W
R
E
L
G
V
D
V
V
L
D
C
T
G
V
Y
G
S
R
E
H
G
E
A
H
I
A
A
G
A
K
K
V
L
F
S
H
P
G
S
N
--
D
L
D
A
T
V
V
Y
G
V
N
Q
D
Q
L
R
-
A
-
E
H
R
I
V
S
N
A
S
C
T
T
N
C
I
I
P
V
I
K
L
L
D
D
A
Y
G
I
E
S
G
T
V
T
T
I
H
S
A
------------
P
D
L
R
R
T
R
A
A
S
Q
S
I
I
P
V
D
T
K
L
A
A
G
I
T
R
F
F
P
Q
F
N
D
R
F
E
A
I
A
V
R
V
P
T
I
N
V
T
A
I
D
L
S
V
T
V
K
K
P
-
V
K
A
N
E
V
N
L
L
L
Q
K
A
A
Q
-------
G
A
F
H
G
I
V
D
Y
T
E
L
P
L
V
S
V
D
F
N
H
D
P
H
S
A
I
V
D
G
T
Q
T
R
V
S
G
A
H
L
I
K
T
L
V
W
C
D
N
E
W
G
F
A
N
R
M
L
D
T
T
L
A
M
A
T
V
----------
39
PsiBlast_CBE
90.23
52%
-107
- C3 -
3GNQ
2
?
E:
[11-337]
-----
I
R
V
A
I
N
G
Y
G
R
I
G
R
N
T
L
R
A
F
Y
E
--
N
G
K
K
H
D
L
E
I
V
A
I
N
D
L
G
D
A
K
T
N
A
H
L
T
Q
Y
D
T
A
H
G
K
F
P
-
G
E
V
S
V
D
-
G
D
Y
L
V
V
N
G
D
R
I
R
V
L
A
N
R
N
P
A
E
L
P
W
G
E
L
G
V
D
V
V
M
E
C
T
G
F
F
T
S
K
E
K
A
S
A
H
L
K
G
G
A
K
K
V
I
I
S
A
P
G
G
K
--
D
V
D
A
T
I
V
Y
G
V
N
H
D
V
L
K
-
A
-
E
H
T
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
V
K
P
L
N
D
K
I
G
L
E
T
G
L
M
T
T
I
H
A
Y
T
N
D
Q
V
L
T
D
V
Y
-
H
E
D
L
R
R
A
R
S
A
T
H
S
Q
I
P
T
K
T
G
A
A
A
A
V
G
L
V
L
P
E
L
N
G
K
L
D
G
Y
A
I
R
V
P
T
I
N
V
S
I
V
D
L
S
F
I
A
K
R
D
-
T
T
A
A
E
V
N
A
I
M
K
E
A
S
E
-------
G
A
L
K
G
I
L
G
Y
N
E
A
P
L
V
S
I
D
F
N
H
N
P
A
S
S
T
F
D
A
T
L
T
K
V
S
G
-
R
L
V
K
V
S
S
W
Y
D
N
E
W
G
F
S
N
R
M
L
D
T
A
I
A
L
A
N
A
K
---------
3
PsiBlast_PDB
90.19
52%
-104
- C3 -
3GNQ
1
?
A:
[11-337]
-----
I
R
V
A
I
N
G
Y
G
R
I
G
R
N
T
L
R
A
F
Y
E
--
N
G
K
K
H
D
L
E
I
V
A
I
N
D
L
G
D
A
K
T
N
A
H
L
T
Q
Y
D
T
A
H
G
K
F
P
-
G
E
V
S
V
D
-
G
D
Y
L
V
V
N
G
D
R
I
R
V
L
A
N
R
N
P
A
E
L
P
W
G
E
L
G
V
D
V
V
M
E
C
T
G
F
F
T
S
K
E
K
A
S
A
H
L
K
G
G
A
K
K
V
I
I
S
A
P
G
G
K
--
D
V
D
A
T
I
V
Y
G
V
N
H
D
V
L
K
-
A
-
E
H
T
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
V
K
P
L
N
D
K
I
G
L
E
T
G
L
M
T
T
I
H
A
Y
T
N
D
Q
V
L
T
D
V
Y
-
H
E
D
L
R
R
A
R
S
A
T
H
S
Q
I
P
T
K
T
G
A
A
A
A
V
G
L
V
L
P
E
L
N
G
K
L
D
G
Y
A
I
R
V
P
T
I
N
V
S
I
V
D
L
S
F
I
A
K
R
D
-
T
T
A
A
E
V
N
A
I
M
K
E
A
S
E
-------
G
A
L
K
G
I
L
G
Y
N
E
A
P
L
V
S
I
D
F
N
H
N
P
A
S
S
T
F
D
A
T
L
T
K
V
S
G
-
R
L
V
K
V
S
S
W
Y
D
N
E
W
G
F
S
N
R
M
L
D
T
A
I
A
L
A
N
A
K
---------
117
HHSearch
88.31
38%
-105
- C3 -
1RM4
3
G3PA_SPIOL
O:
[1-335]
----
K
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
G
--
R
K
D
-
S
P
L
D
V
V
V
I
N
D
T
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
-
A
D
V
K
T
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
--
G
-
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
-
H
-
A
D
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
R
D
L
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
-
D
------
N
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
W
Q
--------
5
PsiBlast_PDB
87.90
49%
-104
- C3 -
3L0D
1
?
A:
[25-349]
------
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
I
E
--
S
G
R
Q
-
D
I
E
V
V
A
L
N
D
L
G
S
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
C
F
P
-
G
T
V
Q
V
V
-
G
D
A
I
D
I
---
L
I
K
V
F
A
E
R
D
P
A
Q
L
P
W
K
A
L
D
I
D
I
A
L
E
C
T
G
I
F
T
A
R
D
K
A
S
A
H
L
D
A
G
A
K
R
V
L
V
S
A
P
--
S
E
G
-
A
D
L
T
V
V
Y
G
V
N
H
Q
F
L
S
-
K
-
E
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
H
N
T
V
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
V
L
D
T
M
-
H
R
D
L
Y
R
A
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
L
L
D
G
V
S
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
T
A
K
R
S
-
T
T
I
E
E
I
N
T
A
I
R
T
A
A
Q
-------
G
S
L
K
G
I
L
D
Y
T
D
E
K
L
V
S
C
D
F
N
H
N
P
H
S
A
I
F
H
N
D
Q
T
K
V
I
D
G
Q
L
C
R
V
L
V
W
Y
D
N
E
W
G
F
S
N
R
M
C
D
T
A
V
A
F
A
K
T
I
---------
46
PsiBlast_CBE
87.46
49%
-105
- C3 -
3L0D
1
?
B:
[25-349]
------
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
I
E
--
S
G
R
Q
-
D
I
E
V
V
A
L
N
D
L
G
S
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
C
F
P
-
G
T
V
Q
V
V
-
G
D
A
I
D
I
---
L
I
K
V
F
A
E
R
D
P
A
Q
L
P
W
K
A
L
D
I
D
I
A
L
E
C
T
G
I
F
T
A
R
D
K
A
S
A
H
L
D
A
G
A
K
R
V
L
V
S
A
P
--
S
E
G
-
A
D
L
T
V
V
Y
G
V
N
H
Q
F
L
S
-
K
-
E
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
H
N
T
V
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
V
L
D
T
M
-
H
R
D
L
Y
R
A
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
L
L
D
G
V
S
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
T
A
K
R
S
-
T
T
I
E
E
I
N
T
A
I
R
T
A
A
Q
-------
G
S
L
K
G
I
L
D
Y
T
D
E
K
L
V
S
C
D
F
N
H
N
P
H
S
A
I
F
H
N
D
Q
T
K
V
I
D
G
Q
L
C
R
V
L
V
W
Y
D
N
E
W
G
F
S
N
R
M
C
D
T
A
V
A
F
A
K
T
I
---------
93
PsiBlast_CBE
87.26
41%
-103
- C3 -
3ZDF
2
?
B:
[20-348]
------
R
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
Q
--
R
K
A
N
S
K
L
E
I
V
G
I
N
D
T
S
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
E
I
T
A
D
-
D
D
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
G
A
K
K
V
L
I
T
A
P
--
G
K
G
N
I
-
P
T
Y
V
V
G
V
N
H
H
T
Y
D
-
P
-
S
E
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
-
S
H
R
D
L
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
E
T
-------
T
M
K
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
H
W
A
--------
94
PsiBlast_CBE
86.81
41%
-104
- C3 -
3ZDF
2
?
A:
[20-348]
------
R
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
Q
--
R
K
A
N
S
K
L
E
I
V
G
I
N
D
T
S
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
E
I
T
A
D
-
D
D
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
G
A
K
K
V
L
I
T
A
P
--
G
K
G
N
I
-
P
T
Y
V
V
G
V
N
H
H
T
Y
D
-
P
-
S
E
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
-
S
H
R
D
L
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
E
T
-------
T
M
K
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
H
W
A
--------
121
HHSearch
86.71
41%
-102
- C3 -
1HDG
3
G3P_THEMA
O:
[1-332]
-----
A
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
RK
N
P
---
D
I
E
V
V
A
I
N
D
L
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
-
G
K
V
E
Y
T
-
E
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
--
G
E
-
D
I
T
V
V
I
G
C
N
E
D
Q
L
K
-
P
-
E
H
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
-
H
K
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
-
E
------
G
R
L
K
G
I
I
G
Y
N
D
E
P
I
V
S
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
G
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
----------
19
PsiBlast_PDB
85.15
42%
-105
- C3 -
1VC2
1
?
A:
[1-331]
-----
M
K
V
G
I
N
G
F
G
R
I
G
R
Q
V
F
R
I
L
H
E
--
R
----
G
V
E
V
A
L
I
N
D
L
T
D
N
K
T
L
A
H
L
L
K
Y
D
S
T
Y
G
R
F
P
-
G
A
V
G
Y
D
-
E
E
N
L
Y
V
D
G
K
A
I
R
A
T
A
I
K
D
P
R
E
I
P
W
K
Q
A
G
V
G
V
V
V
E
S
T
G
V
F
T
D
G
E
K
A
R
A
H
L
E
A
G
A
K
K
V
I
I
T
A
P
A
K
N
E
---
D
I
T
V
V
L
G
V
N
H
E
Q
Y
D
P
A
-
K
H
H
I
L
S
N
A
S
C
T
T
N
S
L
A
P
V
M
K
V
L
E
K
A
F
G
V
E
K
A
L
M
T
T
V
H
S
Y
T
N
D
Q
R
L
L
D
-
L
P
H
K
D
L
R
R
A
R
A
A
A
L
N
I
I
P
T
T
T
G
A
A
K
A
T
A
L
V
L
P
S
L
K
G
R
F
D
G
M
A
L
R
V
P
T
P
T
G
S
I
S
D
I
T
A
L
L
K
R
E
-
V
T
A
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
P
L
K
G
I
L
A
Y
T
E
D
E
I
V
L
R
D
I
V
M
D
P
H
S
S
I
V
D
G
K
L
T
K
A
I
G
-
N
L
V
K
V
F
A
W
Y
D
N
E
W
G
Y
A
N
R
V
A
D
L
V
E
L
V
L
K
K
G
V
--------
125
HHSearch
84.15
39%
-99
- C3 -
2EP7
1
G3P_AQUAE
A:
[3-340]
-----
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
A
S
W
G
--
R
E
---
E
I
E
I
V
A
I
N
D
L
T
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
K
-
G
S
V
E
A
K
-
D
D
S
I
V
V
D
G
K
E
I
K
V
F
A
Q
K
D
P
S
Q
I
P
W
G
D
L
G
V
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
L
Q
G
G
A
K
K
V
I
I
T
A
P
A
K
--
N
P
-
D
I
T
V
V
L
G
V
N
E
E
K
Y
N
-
P
K
E
H
N
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
-
H
K
D
F
R
R
A
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
K
A
P
S
S
V
E
E
V
N
E
K
F
R
E
A
A
Q
K
Y
R
E
SGK
V
Y
L
K
E
I
L
Q
Y
C
E
D
P
I
V
S
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
Q
V
-
I
D
N
L
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
E
R
----------