@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0552: (2016-01-09 )
MTVLKMTDLDLKGKRVLIREDLNVPVKDGQVQSDARIKAALPTLKLALEKGAAVMVCSHLGRPTEGEFSAENSLKPVAEYLSKALGREVPLLADYLDGVEVKAGDLVLFENVRFNKGEKKNADELAQKYAALCDVFVMDAFGTAHRAEGSTHGVARFAKVAAAGPLLAAELDALGKALGNPARPMAAIVAGSKVSTKLDVLNSLAGICDQLIVGGGIANTFLAAAGHKVGKSLYEADLVETAKAIAAKVKVPLPVDVVVAKEFAESAVATVKAIAEVADDDMILDIGPQTAAQFAELLKTSKTILWNGPVGVFEFDQFGEGTRTLANAIADSAAFSIAGGGDTLAAIDKYGIAERISYISTGGGAFLEFVEGKVLPAVEILEQRAKG
Atome Classification :
(60 SA)
.......--..-10........20.......-.-30........40........50.-.-......60..-------------...--...70........80........90.----....------..-------.------100------.-------.-------......110...---------------.--...120------------.-------.--..-----.....130--------.--------------........140.......150.....--..160.........170.......180.......190.......200..--...--..210.......220..-.-..-..230...-------.-------...240.--.-----.....-----.-----.--250.........260-----......---.-.-.-270.....-...280.------......290.......300.......310.......320.......---330--.---.---.-.---..---...340.......350.......360.......370.......380.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
V
L
K
M
T--DL-DLKG
K
R
V
L
I
REDLNVPVKD-G-QVQSDA
R
I
K
AAL
P
T
L
K
L
A
L
EKG
A
-
A
-
V
M
V
C
S
HLGRP-------------TEG--EFSAENS
L
K
P
V
A
E
Y
L
S
K
A
LGREV
P
L
L
----
A
D
YL------DG-------
V
------
E
V-------K-------A-------G
D
L
V
L
F
ENVRFN---------------K--GEKK--------------
N
-------
A
--
D
E
-----
L
A
Q
K
Y
A
----------
A
--------------
L
C
D
V
F
V
M
DAFGTAHRAEGST
H
G
V
A
R
F
--
A
K
V
--AAAG
P
L
L
A
A
E
L
D
A
L
G
K
A
LGNPARP
M
A
A
I
VAGSK
V
S
T
K
L
D
V
L
N
S
L
--
A
G
I
--
C
D
Q
L
IVGG
G
I
A
N
T
F
L
A
A-A-
G
H
-
K
V
G
K
S
L
Y
E
-------
A
-------
D
L
V
E
--
T
--
A
-----
K
A
I
A
A
-----
K
-----V--K--VPL
P
V
D
V
V
V
A
-------
K
E
F
A
E
S
---
A
-
V
-
A
-
T
V
-
K
A
I
A
E
-VADD
D
M
I
------
L
DIG
P
Q
T
A
A
Q
F
A
E
L
L
KTS
K
T
I
L
WNGPVGV
F
E
F
D
QFG
E
G
T
R
T
L
A
N
A
I
---A----D---S---
A
-
A
---
F
S
---IAGGG
D
T
L
A
A
I
D
KY
G
I
A
E
R
I
S
Y
ISTG
G
G
A
F
L
E
F
VEGKV
L
P
A
V
E
I
L
E
Q
RAKG
1
PsiBlast_PDB
98.38
74%
-118
- C9 -
5BT8
-
?
A:
[9-403]
M
N
F
Q
R
M
T
--
D
L
-
N
L
A
G
K
R
V
L
I
R
E
D
L
N
V
P
V
K
N
-
G
-
V
I
T
S
D
A
R
L
R
A
A
L
P
T
I
K
A
A
L
E
K
G
A
-
A
-
V
M
V
F
S
H
L
G
R
P
-------------
V
E
G
--
E
P
K
P
E
Q
S
L
A
P
V
A
A
Y
L
T
E
A
L
G
Q
E
V
K
L
F
----
T
D
Y
L
------
D
G
-------
V
------
E
V
-------
E
-------
A
-------
G
Q
V
V
L
L
E
N
V
R
F
N
---------------
P
--
G
E
K
K
--------------
N
-------
N
--
P
E
-----
L
A
Q
K
Y
A
----------
A
--------------
L
C
D
V
F
V
M
D
A
F
G
T
A
H
R
A
E
A
S
T
E
G
V
A
R
F
--
A
P
V
--
A
A
A
G
P
L
L
A
A
E
L
D
A
L
G
R
A
M
Q
T
P
E
K
P
M
V
A
I
V
A
G
S
K
V
S
T
K
L
D
V
L
N
S
L
--
S
G
I
--
C
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
A
A
-
A
-
G
Y
-
N
V
G
K
S
L
Y
E
-------
A
-------
D
L
V
E
--
T
--
A
-----
K
Q
I
A
A
-----
K
-----
V
--
S
--
V
P
L
P
T
D
V
V
V
A
D
ASQINF
E
D
F
L
G
S
L
A
A
A
-
Q
-
A
-
V
I
-
K
K
V
E
D
-
V
T
A
N
D
M
I
------
L
D
V
G
P
E
T
A
K
A
F
A
N
I
L
T
T
S
K
T
I
L
W
N
G
P
V
G
V
F
E
V
D
Q
F
G
E
G
T
K
A
L
S
L
A
V
---
A
----
Q
---
S
---
D
-
A
---
F
S
---
I
A
G
G
G
D
T
L
A
A
I
D
K
Y
N
V
A
D
Q
I
G
Y
I
S
T
G
G
G
A
F
L
E
F
V
E
G
K
T
L
P
A
V
A
V
L
L
E
R
A
--
60
HHSearch
96.93
71%
-119
- C9 -
1ZMR
3
PGK_ECOLI
A:
[2-386]
-
S
V
I
K
M
T
--
D
L
-
D
L
A
G
K
R
V
F
I
R
A
D
L
N
V
P
V
K
D
-
G
-
K
V
T
S
D
A
R
I
R
A
S
L
P
T
I
E
L
A
L
K
Q
G
A
-
K
-
V
M
V
T
S
H
L
G
R
P
-------------
T
E
G
--
E
Y
N
E
E
F
S
L
L
P
V
V
N
Y
L
K
D
K
L
S
N
P
V
R
L
V
----
K
D
Y
L
------
D
G
-------
V
------
D
V
-------
A
-------
E
-------
G
E
L
V
V
L
E
N
V
R
F
N
---------------
K
--
G
E
K
K
--------------
D
-------
D
--
E
T
-----
L
S
K
K
Y
A
----------
A
--------------
L
C
D
V
F
V
M
D
A
F
G
T
A
H
R
A
Q
A
S
T
H
G
I
G
K
F
--
A
D
V
--
A
C
A
G
P
L
L
A
A
E
L
D
A
L
G
K
A
L
K
E
P
A
R
P
M
V
A
I
V
G
G
S
K
V
S
T
K
L
T
V
L
D
S
L
--
S
K
I
--
A
D
Q
L
I
V
G
G
G
I
A
N
T
F
I
A
A
-
Q
-
G
H
-
D
V
G
K
S
L
Y
E
-------
A
-------
D
L
V
D
--
E
--
A
-----
K
R
L
L
T
-----
T
-----
C
--
N
--
I
P
V
P
S
D
V
R
V
A
-------
T
E
F
S
E
T
---
A
-
P
-
A
-
T
L
-
K
S
V
N
D
-
V
K
A
D
E
Q
I
------
L
D
I
G
D
A
S
A
Q
E
L
A
E
I
L
K
N
A
K
T
I
L
W
N
G
P
V
G
V
F
E
F
P
N
F
R
K
G
T
E
I
V
A
N
A
I
---
A
----
D
---
S
---
E
-
A
---
F
S
---
I
A
G
G
G
D
T
L
A
A
I
D
L
F
G
I
A
D
K
I
S
Y
I
S
T
G
G
G
A
F
L
E
F
V
E
G
K
V
L
P
A
V
A
M
L
E
E
R
A
K
K
2
PsiBlast_PDB
96.63
70%
-119
- C9 -
1ZMR
3
PGK_ECOLI
A:
[2-386]
-
S
V
I
K
M
T
--
D
L
-
D
L
A
G
K
R
V
F
I
R
A
D
L
N
V
P
V
K
D
-
G
-
K
V
T
S
D
A
R
I
R
A
S
L
P
T
I
E
L
A
L
K
Q
G
A
-
K
-
V
M
V
T
S
H
L
G
R
P
-------------
T
E
G
--
E
Y
N
E
E
F
S
L
L
P
V
V
N
Y
L
K
D
K
L
S
N
P
V
R
L
V
----
K
D
Y
L
------
D
G
-------
V
------
D
V
-------
A
-------
E
-------
G
E
L
V
V
L
E
N
V
R
F
N
---------------
K
--
G
E
K
K
--------------
D
-------
D
--
E
T
-----
L
S
K
K
Y
A
----------
A
--------------
L
C
D
V
F
V
M
D
A
F
G
T
A
H
R
A
Q
A
S
T
H
G
I
G
K
F
--
A
D
V
--
A
C
A
G
P
L
L
A
A
E
L
D
A
L
G
K
A
L
K
E
P
A
R
P
M
V
A
I
V
G
G
S
K
V
S
T
K
L
T
V
L
D
S
L
--
S
K
I
--
A
D
Q
L
I
V
G
G
G
I
A
N
T
F
I
A
A
-
Q
-
G
H
-
D
V
G
K
S
L
Y
E
-------
A
-------
D
L
V
D
--
E
--
A
-----
K
R
L
L
T
-----
T
-----
C
--
N
--
I
P
V
P
S
D
V
R
V
A
-------
T
E
F
S
E
T
---
A
-
P
-
A
-
T
L
-
K
S
V
N
D
-
V
K
A
D
E
Q
I
------
L
D
I
G
D
A
S
A
Q
E
L
A
E
I
L
K
N
A
K
T
I
L
W
N
G
P
V
G
V
F
E
F
P
N
F
R
K
G
T
E
I
V
A
N
A
I
---
A
----
D
---
S
---
E
-
A
---
F
S
---
I
A
G
G
G
D
T
L
A
A
I
D
L
F
G
I
A
D
K
I
S
Y
I
S
T
G
G
G
A
F
L
E
F
V
E
G
K
V
L
P
A
V
A
M
L
E
E
R
A
K
K
3
PsiBlast_PDB
92.45
60%
-112
- C9 -
4FEY
1
PGK_FRATT
A:
[4-393]
M
S
F
L
T
L
K
--
D
V
-
D
L
K
D
K
K
V
L
V
R
V
D
F
N
V
P
V
K
D
-
G
-
K
V
T
S
K
V
R
I
E
A
A
I
P
T
I
Q
Y
I
L
D
Q
G
G
-
A
-
V
I
L
M
S
H
L
G
R
P
-------------
T
E
G
--
E
Y
D
S
Q
F
S
L
E
P
V
A
K
A
L
S
E
I
I
N
K
P
V
K
F
A
----
K
D
W
L
------
D
G
-------
V
------
D
V
-------
K
-------
A
-------
G
E
I
V
M
C
E
N
V
R
F
N
---------------
S
--
G
E
K
K
--------------
S
-------
T
--
D
D
-----
L
S
K
K
I
A
----------
S
--------------
L
G
D
V
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
Y
G
V
A
K
Y
--
I
P
V
--
A
C
A
G
I
L
L
T
N
E
I
Q
A
L
E
K
A
L
K
S
P
K
K
P
M
A
A
I
V
G
G
S
K
V
S
T
K
L
S
V
L
N
N
L
--
L
D
K
--
V
E
I
L
I
V
G
G
G
I
A
N
T
F
I
K
A
-
E
-
G
F
-
D
V
G
N
S
L
Y
E
-------
Q
-------
D
L
V
A
--
E
--
A
-----
T
E
I
L
A
-----
K
A
K
A
L
G
V
--
N
--
I
P
V
P
V
D
V
R
V
A
-------
K
E
F
S
E
N
---
A
-
Q
-
A
-
I
I
-
K
K
V
S
D
-
V
V
A
D
E
M
I
------
L
D
I
G
P
E
S
Q
K
I
I
A
E
L
L
K
S
A
N
T
I
L
W
N
G
P
V
G
V
F
E
F
D
N
F
A
E
G
T
K
A
L
S
L
A
I
---
A
----
Q
---
S
---
H
-
A
---
F
S
---
V
A
G
G
G
D
T
I
A
A
I
E
K
F
G
I
K
D
Q
V
S
Y
I
S
T
A
G
G
A
F
L
E
F
L
E
G
K
K
L
P
A
I
E
I
L
K
E
K
A
I
R
4
PsiBlast_PDB
92.31
59%
-116
- C9 -
4EHJ
1
PGK_FRATT
A:
[2-390]
-
S
F
L
T
L
K
--
D
V
-
D
L
K
D
K
K
V
L
V
R
V
D
F
N
V
P
V
K
D
-
G
-
K
V
T
S
K
V
R
I
E
A
A
I
P
T
I
Q
Y
I
L
D
Q
G
G
-
A
-
V
I
L
M
S
H
L
G
R
P
-------------
T
E
G
--
E
Y
D
S
Q
F
S
L
E
P
V
A
K
A
L
S
E
I
I
N
K
P
V
K
F
A
----
K
D
W
L
------
D
G
-------
V
------
D
V
-------
K
-------
A
-------
G
E
I
V
M
C
E
N
V
R
F
N
---------------
S
--
G
E
K
K
--------------
S
-------
T
--
D
D
-----
L
S
K
K
I
A
----------
S
--------------
L
G
D
V
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
Y
G
V
A
K
Y
--
I
P
V
--
A
C
A
G
I
L
L
T
N
E
I
Q
A
L
E
K
A
L
K
S
P
K
K
P
M
A
A
I
V
G
G
S
K
V
S
T
K
L
S
V
L
N
N
L
--
L
D
K
--
V
E
I
L
I
V
G
G
G
I
A
N
T
F
I
K
A
-
E
-
G
F
-
D
V
G
N
S
L
Y
E
-------
Q
-------
D
L
V
A
--
E
--
A
-----
T
E
I
L
A
-----
K
A
K
A
L
G
V
--
N
--
I
P
V
P
V
D
V
R
V
A
-------
K
E
F
S
E
N
---
A
-
Q
-
A
-
I
I
-
K
K
V
S
D
-
V
V
A
D
E
M
I
------
L
D
I
G
P
E
S
Q
K
I
I
A
E
L
L
K
S
A
N
T
I
L
W
N
G
P
V
G
V
F
E
F
D
N
F
A
E
G
T
K
A
L
S
L
A
I
---
A
----
Q
---
S
---
H
-
A
---
F
S
---
V
A
G
G
G
D
T
I
A
A
I
E
K
F
G
I
K
D
Q
V
S
Y
I
S
T
A
G
G
A
F
L
E
F
L
E
G
K
K
L
P
A
I
E
I
L
K
E
K
A
I
-
22
PsiBlast_CBE
91.26
57%
-112
- C9 -
4NG4
2
PGK_COXBU
B:
[13-402]
-
P
F
L
S
M
S
--
N
L
-
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
K
N
-
G
-
K
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
-
R
-
V
M
I
L
S
H
L
G
R
P
-------------
E
E
G
--
K
F
E
K
E
F
S
L
A
P
V
A
R
L
L
S
K
K
L
N
-
K
V
P
L
I
----
N
D
W
L
------
K
G
-------
V
------
A
V
-------
E
-------
P
-------
G
Q
A
I
L
C
E
N
V
R
F
N
---------------
K
--
G
E
N
E
--------------
N
-------
N
--
T
E
-----
L
A
K
R
M
A
----------
E
--------------
L
C
D
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
--
A
K
L
--
A
C
A
G
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
--
L
D
K
--
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
-
Q
-
G
Y
-
S
I
G
K
S
L
C
E
-------
N
-------
E
W
L
D
--
A
--
A
Q
Q
F
W
E
K
A
A
E
K
-----
N
-----
V
--
S
--
L
P
L
P
V
D
V
I
V
A
-------
D
E
L
S
E
D
---
A
-
K
-
A
-
T
V
-
K
N
I
D
A
-
V
T
S
N
E
S
I
------
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
R
A
L
A
Q
A
V
---
A
----
K
---
S
---
T
-
A
---
Y
S
---
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
K
I
L
P
A
I
K
I
L
T
Q
R
A
K
-
21
PsiBlast_CBE
91.26
57%
-114
- C9 -
4NG4
2
PGK_COXBU
C:
[13-402]
-
P
F
L
S
M
S
--
N
L
-
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
K
N
-
G
-
K
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
-
R
-
V
M
I
L
S
H
L
G
R
P
-------------
E
E
G
--
K
F
E
K
E
F
S
L
A
P
V
A
R
L
L
S
K
K
L
N
--
V
P
L
I
----
N
D
W
L
------
K
G
-------
V
------
A
V
-------
E
-------
P
-------
G
Q
A
I
L
C
E
N
V
R
F
N
---------------
K
--
G
E
N
E
--------------
N
-------
N
--
T
E
-----
L
A
K
R
M
A
----------
E
--------------
L
C
D
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
--
A
K
L
--
A
C
A
G
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
--
L
D
K
--
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
-
Q
-
G
Y
-
S
I
G
K
S
L
C
E
-------
N
-------
E
W
L
D
--
A
--
A
Q
Q
F
W
E
K
A
A
E
K
-----
N
-----
V
--
S
--
L
P
L
P
V
D
V
I
V
A
-------
D
E
L
S
E
D
---
A
-
K
-
A
-
T
V
-
K
N
I
D
A
-
V
T
S
N
E
S
I
------
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
R
A
L
A
Q
A
V
---
A
----
K
---
S
---
T
-
A
---
Y
S
---
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
--
L
P
A
I
K
I
L
T
Q
R
A
K
E
5
PsiBlast_PDB
89.52
57%
-109
- C9 -
4NG4
2
PGK_COXBU
A:
[13-402]
-
P
F
L
S
M
S
--
N
L
-
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
K
N
-
G
-
K
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
-
R
-
V
M
I
L
S
H
L
G
R
P
-------------
E
E
G
--
K
F
E
K
E
F
S
L
A
P
V
A
R
L
L
S
K
K
-----
P
L
I
----
N
D
W
L
------
K
G
-------
V
------
A
V
-------
E
-------
P
-------
G
Q
A
I
L
C
E
N
V
R
F
N
---------------
K
--
G
E
N
E
--------------
N
-------
N
--
T
E
-----
L
A
K
R
M
A
----------
E
--------------
L
C
D
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
--
A
K
L
--
A
C
A
G
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
--
L
D
K
--
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
-
Q
-
G
Y
-
S
I
G
K
S
L
C
E
-------
N
-------
E
W
L
D
--
A
--
A
Q
Q
F
W
E
K
A
A
E
K
-----
N
-----
V
--
S
--
L
P
L
P
V
D
V
I
V
A
-------
D
E
L
S
E
D
---
A
-
K
-
A
-
T
V
-
K
N
I
D
A
-
V
T
S
N
E
S
I
------
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
R
A
L
A
Q
A
V
---
A
----
K
---
S
---
T
-
A
---
Y
S
---
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
K
-
L
P
A
I
K
I
L
T
Q
R
A
K
-
7
PsiBlast_PDB
85.07
47%
-100
- C9 -
1VPE
3
PGKT_THEMA
A:
[2-390]
----
K
M
T
IR
D
V
-
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
V
K
D
-
G
-
V
V
Q
D
D
T
R
I
R
A
A
L
P
T
I
K
Y
A
L
E
Q
G
A
-
K
-
V
I
L
L
S
H
L
G
R
P
--------------
K
G
--
E
P
S
P
E
F
S
L
A
P
V
A
K
R
L
S
E
L
L
G
K
E
V
K
F
V
----
P
A
V
V
G-----
D
E
-------
V
K
K
A
V
E
-
E
L
-------
K
-------
E
-------
G
E
V
L
L
L
E
N
T
R
F
H
---------------
P
--
G
E
T
K
--------------
N
-------
D
--
P
E
-----
L
A
K
F
W
A
----------
S
--------------
L
A
D
I
H
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
A
Q
F
--
I
P
---
S
V
A
G
F
L
M
E
K
E
I
K
F
L
S
K
V
T
Y
N
P
E
K
P
Y
V
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
T
N
L
--
M
E
K
--
A
D
R
I
L
I
G
G
A
M
M
F
T
F
L
K
A
-
L
-
G
K
-
E
V
G
S
S
R
V
E
-------
E
-------
D
K
I
D
--
L
--
A
-----
K
E
L
V
E
-----
K
A
K
E
K
G
V
--
E
--
I
V
L
P
V
D
A
V
I
A
-------
Q
K
I
E
P
G
---
V
-
E
-
K
-
K
V
-
V
R
I
D
D
G
I
P
E
G
W
M
G
------
L
D
I
G
P
E
T
I
E
L
F
K
Q
K
L
S
D
A
K
T
V
V
W
N
G
P
M
G
V
F
E
I
D
D
F
A
E
G
T
K
Q
V
A
L
A
I
---
A
A
L
T
-
E
---
K
---
G
-
A
---
I
T
---
V
V
G
G
G
D
S
A
A
A
V
N
K
F
G
L
E
D
K
F
S
H
V
S
T
G
G
G
A
S
L
E
F
L
E
G
K
E
L
P
G
I
A
S
M
R
I
K
K
A
-
65
HHSearch
84.96
47%
-98
- C9 -
1VPE
3
PGKT_THEMA
A:
[2-397]
--
K
M
T
I
R
--
D
V
-
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
V
K
D
-
G
-
V
V
Q
D
D
T
R
I
R
A
A
L
P
T
I
K
Y
A
L
E
Q
G
A
-
K
-
V
I
L
L
S
H
L
G
R
P
-------------
K
-
G
--
E
P
S
P
E
F
S
L
A
P
V
A
K
R
L
S
E
L
L
G
K
E
V
K
F
V
----
P
A
V
V
------
G
D
E
V
K
K
A
V
-
E
------
E
L
-------
K
-------
E
-------
G
E
V
L
L
L
E
N
T
R
F
H
---------------
P
--
G
E
T
K
--------------
N
-------
D
--
P
E
-----
L
A
K
F
W
A
----------
S
--------------
L
A
D
I
H
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
A
Q
F
--
I
P
---
S
V
A
G
F
L
M
E
K
E
I
K
F
L
S
K
V
T
Y
N
P
E
K
P
Y
V
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
T
N
L
--
M
E
K
--
A
D
R
I
L
I
G
G
A
M
M
F
T
F
L
K
A
-
L
-
G
K
-
E
V
G
S
S
R
V
E
-------
E
-------
D
K
I
D
--
L
--
A
-----
K
E
L
V
E
K
A
K
E
K
G
-----
V
--
E
--
I
V
L
P
V
D
A
V
I
A
-------
Q
K
I
E
P
G
---
V
-
E
-
K
-
K
V
V
R
I
D
D
G
-
I
P
E
G
W
M
G
------
L
D
I
G
P
E
T
I
E
L
F
K
Q
K
L
S
D
A
K
T
V
V
W
N
G
P
M
G
V
F
E
I
D
D
F
A
E
G
T
K
Q
V
A
L
A
I
---
A
----
A
---
L
T
E
K
G
-
A
---
I
T
---
V
V
G
G
G
D
S
A
A
A
V
N
K
F
G
L
E
D
K
F
S
H
V
S
T
G
G
G
A
S
L
E
F
L
E
G
K
E
L
P
G
I
A
S
M
R
I
K
K
A
-
62
HHSearch
84.95
48%
-105
- C9 -
1PHP
2
PGK_GEOSE
A:
[1-394]
M
N
K
K
T
I
R
--
D
V
-
D
V
R
G
K
R
V
F
C
R
V
D
F
N
V
P
M
E
Q
-
G
-
A
I
T
D
D
T
R
I
R
A
A
L
P
T
I
R
Y
L
I
E
H
G
A
-
K
-
V
I
L
A
S
H
L
G
R
P
-------------
K
-
G
--
K
V
V
E
E
L
R
L
D
A
V
A
K
R
L
G
E
L
L
E
R
P
V
A
K
T
----
N
E
A
V
------
G
D
E
V
K
A
A
V
-
D
------
R
L
-------
N
-------
E
-------
G
D
V
L
L
L
E
N
V
R
F
Y
---------------
P
--
G
E
E
K
--------------
N
-------
D
--
P
E
-----
L
A
K
A
F
A
----------
E
--------------
L
A
D
L
Y
V
N
D
A
F
G
A
A
H
R
A
H
A
S
T
E
G
I
A
H
Y
--
L
P
---
A
V
A
G
F
L
M
E
K
E
L
E
V
L
G
K
A
L
S
N
P
D
R
P
F
T
A
I
I
G
G
A
K
V
K
D
K
I
G
V
I
D
N
L
--
L
E
K
--
V
D
N
L
I
I
G
G
G
L
A
Y
T
F
V
K
A
-
L
-
G
H
-
D
V
G
K
S
L
L
E
-------
E
-------
D
K
I
E
--
L
--
A
-----
K
S
F
M
E
-----
K
A
K
E
K
G
V
--
R
--
F
Y
M
P
V
D
V
V
V
A
-------
D
R
F
A
N
D
---
A
-
N
-
T
-
K
V
-
V
P
I
D
A
-
I
P
A
D
W
S
A
------
L
D
I
G
P
K
T
R
E
L
Y
R
D
V
I
R
E
S
K
L
V
V
W
N
G
P
M
G
V
F
E
M
D
A
F
A
H
G
T
K
A
I
A
E
A
L
---
A
----
E
---
A
L--
D
-
T
---
Y
S
---
V
I
G
G
G
D
S
A
A
A
V
E
K
F
G
L
A
D
K
M
D
H
I
S
T
G
G
G
A
S
L
E
F
M
E
G
K
Q
L
P
G
V
V
A
L
E
D
K
---
6
PsiBlast_PDB
84.81
47%
-106
- C9 -
1PHP
2
PGK_GEOSE
A:
[1-394]
M
N
K
K
T
I
R
--
D
V
-
D
V
R
G
K
R
V
F
C
R
V
D
F
N
V
P
M
E
Q
-
G
-
A
I
T
D
D
T
R
I
R
A
A
L
P
T
I
R
Y
L
I
E
H
G
A
-
K
-
V
I
L
A
S
H
L
G
R
P
--------------
K
G
--
K
V
V
E
E
L
R
L
D
A
V
A
K
R
L
G
E
L
L
E
R
P
V
A
K
T
----
N
E
A
V
-------
G
-------
D
------
E
V
-------
K
-------
A
A
V
D
R
LNE
G
D
V
L
L
L
E
N
V
R
F
Y
---------------
P
--
G
E
E
K
--------------
N
-------
D
--
P
E
-----
L
A
K
A
F
A
----------
E
--------------
L
A
D
L
Y
V
N
D
A
F
G
A
A
H
R
A
H
A
S
T
E
G
I
A
H
Y
--
L
P
---
A
V
A
G
F
L
M
E
K
E
L
E
V
L
G
K
A
L
S
N
P
D
R
P
F
T
A
I
I
G
G
A
K
V
K
D
K
I
G
V
I
D
N
L
--
L
E
K
--
V
D
N
L
I
I
G
G
G
L
A
Y
T
F
V
K
A
-
L
-
G
H
-
D
V
G
K
S
L
L
E
-------
E
-------
D
K
I
E
--
L
--
A
-----
K
S
F
M
E
-----
K
A
K
E
K
G
V
--
R
--
F
Y
M
P
V
D
V
V
V
A
-------
D
R
F
A
N
D
---
A
-
N
-
T
-
K
V
-
V
P
I
D
A
-
I
P
A
D
W
S
A
------
L
D
I
G
P
K
T
R
E
L
Y
R
D
V
I
R
E
S
K
L
V
V
W
N
G
P
M
G
V
F
E
M
D
A
F
A
H
G
T
K
A
I
A
E
A
L
---
A
----
E
---
A
---
L
D
T
---
Y
S
---
V
I
G
G
G
D
S
A
A
A
V
E
K
F
G
L
A
D
K
M
D
H
I
S
T
G
G
G
A
S
L
E
F
M
E
G
K
Q
L
P
G
V
V
A
L
E
D
K
---
53
PsiBlast_CBE
83.74
38%
-114
- C9 -
3OZ7
2
PGK_PLAF7
B:
[8-412]
---
L
S
I
S
--
D
L
K
D
I
K
N
K
K
V
L
V
R
V
D
F
N
V
P
I
E
N
-
G
-
I
I
K
D
T
N
R
I
T
A
T
L
P
T
I
N
H
L
K
K
E
G
A
-
S
K
I
I
L
I
S
H
C
G
R
P
--------------
D
G
--
L
R
N
E
K
Y
T
L
K
P
V
A
E
T
L
K
G
L
L
G
E
E
V
L
F
L
----
N
D
C
V
-------
G
-------
K
------
E
V
E
D
K
I
N
A
A
K
-------
E
-------
N
S
V
I
L
L
E
N
L
R
F
H
IEEEG
K
G
V
D
ANG
N
K
V
K
--
A
N
K
E
--------------
D
-------
V
--
E
K
-----
F
Q
N
D
L
T
----------
K
--------------
L
A
D
V
F
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
K
----
L
N
V
--
K
A
S
G
F
L
M
K
K
E
L
E
Y
F
S
K
A
L
E
N
P
Q
R
P
L
L
A
I
L
G
G
A
K
V
S
D
K
I
Q
L
I
K
N
L
--
L
D
K
--
V
D
R
M
I
I
G
G
G
M
A
Y
T
F
K
K
V
-
L
-
N
N
M
K
I
G
T
S
L
F
D
E
A
G
S
K
I
V
G
-------
E
I
M
E
--
K
--
A
-----
K
--
A
K
-----
N
-----
V
--
Q
--
I
F
L
P
V
D
F
K
I
A
-------
D
N
F
D
N
N
---
A
-
N
-
T
-
K
F
-
V
T
D
E
E
G
I
P
D
N
W
M
G
------
L
D
A
G
P
K
S
I
E
N
Y
K
D
V
I
L
T
S
K
T
V
I
W
N
G
P
Q
G
V
F
E
M
P
N
F
A
K
G
S
I
E
C
L
N
L
V
---
V
----
E
V
T
K
K
---
G
-
A
---
I
T
---
I
V
G
G
G
D
T
A
S
L
V
E
Q
Q
N
K
K
N
E
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
L
A
L
S
N
----
8
PsiBlast_PDB
83.48
43%
-107
- C9 -
4DG5
-
PGK_STAAR
A:
[6-396]
-----
V
S
--
D
L
-
D
L
K
G
K
T
V
L
V
R
A
D
F
N
V
P
L
K
D
-
G
-
E
I
T
N
D
N
R
I
V
Q
A
L
P
T
I
Q
Y
I
I
E
Q
G
G
-
K
-
I
V
L
F
S
H
L
G
K
V
-------------
K
E
E
--
S
D
K
A
K
L
T
L
R
P
V
A
E
D
L
S
K
K
L
D
K
E
V
V
F
V
PETR
G
E
K
L
------
E
A
-------
A
I
K
----
D
L
-------
K
-------
E
-------
G
D
V
L
L
V
E
N
T
R
Y
E
D
L
D
G-----------
K
--
K
E
S
K
--------------
N
-------
D
--
P
E
-----
L
G
K
Y
W
A
----------
S
--------------
L
G
D
V
F
V
N
D
A
F
G
T
A
H
R
E
H
A
S
N
V
G
I
S
T
H
--
L
E
---
T
A
A
G
F
L
M
D
K
E
I
K
F
I
G
G
V
V
N
D
P
H
K
P
V
V
A
I
L
G
G
A
K
V
S
D
K
I
N
V
I
K
N
L
--
V
N
I
--
A
D
K
I
I
I
G
G
G
M
A
Y
T
F
L
K
A
-
Q
-
G
K
-
E
I
G
I
S
L
L
E
-------
E
-------
D
K
I
D
--
F
--
A
-----
K
D
L
L
E
-----
K
-----
H
GD
K
--
I
V
L
P
V
D
T
K
V
A
-------
K
E
F
S
N
D
---
A
-
K
-
I
-
T
V
-
V
P
S
D
S
-
I
P
A
D
Q
E
G
------
M
D
I
G
P
N
T
V
K
L
F
A
D
E
L
E
G
A
H
T
V
V
W
N
G
P
M
G
V
F
E
F
S
N
F
A
Q
G
T
I
G
V
C
K
A
I
---
A
----
N
L--
K
---
D
-
A
---
I
T
---
I
I
G
G
G
D
S
A
A
A
A
I
S
L
G
F
E
N
D
F
T
H
I
S
T
G
G
G
A
S
L
E
Y
L
E
G
K
E
L
P
G
I
K
A
I
N
N
K
---
54
PsiBlast_CBE
82.91
38%
-111
- C9 -
3OZ7
2
PGK_PLAF7
A:
[8-412]
---
L
S
I
S
--
D
L
K
D
I
K
N
K
K
V
L
V
R
V
D
F
N
V
P
I
E
N
-
G
-
I
I
K
D
T
N
R
I
T
A
T
L
P
T
I
N
H
L
K
K
E
G
A
-
S
K
I
I
L
I
S
H
C
G
R
P
--------------
D
G
--
L
R
N
E
K
Y
T
L
K
P
V
A
E
T
L
K
G
L
L
G
E
E
V
L
F
L
----
N
D
C
V
-------
G
-------
K
------
E
V
E
D
K
I
N
A
A
K
-------
E
-------
N
S
V
I
L
L
E
N
L
R
F
H
IEEEG
K
G
V
D
ANG
N
K
V
K
--
A
N
K
E
--------------
D
-------
V
--
E
K
-----
F
Q
N
D
L
T
----------
K
--------------
L
A
D
V
F
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
K
----
L
N
V
--
K
A
S
G
F
L
M
K
K
E
L
E
Y
F
S
K
A
L
E
N
P
Q
R
P
L
L
A
I
L
G
G
A
K
V
S
D
K
I
Q
L
I
K
N
L
--
L
D
K
--
V
D
R
M
I
I
G
G
G
M
A
Y
T
F
K
K
V
-
L
-
N
N
M
K
I
G
T
S
L
F
D
E
A
G
S
K
I
V
G
-------
E
I
M
E
--
K
--
A
-----
K
--
A
K
-----
N
-----
V
--
Q
--
I
F
L
P
V
D
F
K
I
A
-------
D
N
F
D
N
N
---
A
-
N
-
T
-
K
F
-
V
T
D
E
E
G
I
P
D
N
W
M
G
------
L
D
A
G
P
K
S
I
E
N
Y
K
D
V
I
L
T
S
K
T
V
I
W
N
G
P
Q
G
V
F
E
M
P
N
F
A
K
G
S
I
E
C
L
N
L
V
---
V
----
E
V
T
K
K
---
G
-
A
---
I
T
---
I
V
G
G
G
D
T
A
S
L
V
E
Q
Q
N
K
K
N
E
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
L
A
L
S
N
----
61
HHSearch
82.62
42%
-104
* C9 *
3Q3V
5
PGK_CAMJE
A:
[6-399]
-
D
I
I
S
I
K
--
D
I
-
D
L
A
K
K
K
V
F
I
R
C
D
F
N
V
P
Q
D
D
F
L
-
N
I
T
D
D
R
R
I
R
S
A
I
P
T
I
R
Y
C
L
D
N
G
C
-
S
-
V
I
L
A
S
H
L
G
R
P
-------------
K
-
E
--
I
-
S
S
K
Y
S
L
E
P
V
A
K
R
L
A
R
L
L
D
K
E
I
V
M
A
----
K
D
V
I
------
G
E
D
A
K
T
K
A
-
M
------
N
L
-------
K
-------
A
-------
G
E
I
L
L
L
E
N
L
R
F
E
---------------
K
--
G
E
T
K
--------------
N
-------
D
--
E
N
-----
L
A
K
E
L
A
----------
S
--------------
M
V
Q
V
Y
I
N
D
A
F
G
V
C
H
R
A
H
S
S
V
E
A
I
T
K
F
--
F
D
E
KH
K
G
A
G
F
L
L
Q
K
E
I
D
F
A
S
N
L
I
K
H
P
A
R
P
F
V
A
V
V
G
G
S
K
V
S
G
K
L
Q
A
L
T
N
L
--
L
P
K
--
V
D
K
L
I
I
G
G
G
M
A
F
T
F
L
K
A
-
L
-
G
Y
-
D
I
G
N
S
L
L
E
-------
E
-------
E
L
L
E
--
E
--
A
-----
N
K
I
L
T
-----
K
G
K
N
L
G
V
--
K
--
I
Y
L
P
V
D
V
V
A
A
-------
P
A
C
S
Q
D
---
V
-
P
-
M
-
K
F
-
V
P
A
Q
E
-
I
P
N
G
W
M
G
------
L
D
I
G
P
A
S
V
R
L
F
K
E
V
I
S
D
A
Q
T
I
W
W
N
G
P
M
G
V
F
E
I
D
K
F
S
K
G
S
I
K
M
S
H
Y
I
---
S
----
E
---
G
---
H
-
A
---
T
S
---
V
V
G
G
G
D
T
A
D
V
V
A
R
A
G
D
A
D
E
M
T
F
I
S
T
G
G
G
A
S
L
E
L
I
E
G
K
E
L
P
G
V
K
A
L
R
S
----
63
HHSearch
82.50
46%
-103
- C9 -
1V6S
3
PGK_THET8
A:
[1-390]
--
M
R
T
L
L
--
D
L
-
D
P
K
G
K
R
V
L
V
R
V
D
Y
N
V
P
V
Q
D
-
G
-
K
V
Q
D
E
T
R
I
L
E
S
L
P
T
L
R
H
L
L
A
G
G
A
-
S
-
L
V
L
L
S
H
L
G
R
P
-------------
K
-
G
--
P
-
D
P
K
Y
S
L
A
P
V
G
E
A
L
R
A
H
L
P
-
E
A
R
F
A
----
P
F
P
P
------
G
S
E
E
A
R
R
E
A
E
------
A
L
-------
R
-------
P
-------
G
E
V
L
L
L
E
N
V
R
F
E
---------------
P
--
G
E
E
K
--------------
N
-------
D
--
P
E
-----
L
S
A
R
Y
A
----------
R
--------------
L
G
E
A
F
V
L
D
A
F
G
S
A
H
R
A
H
A
S
V
V
G
V
A
R
L
--
L
P
---
A
Y
A
G
F
L
M
E
K
E
V
R
A
L
S
R
L
L
K
D
P
E
R
P
Y
A
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
E
S
L
--
L
P
R
--
I
D
R
L
L
I
G
G
A
M
A
F
T
F
L
K
A
-
L
-
G
G
-
E
V
G
R
S
L
V
E
-------
E
-------
D
R
L
D
--
L
--
A
-----
K
D
L
L
G
R
A
E
A
L
G
-----
V
--
R
--
V
Y
L
P
E
D
V
V
A
A
-------
E
R
I
E
A
G
---
V
-
E
-
T
-
R
V
-
F
P
A
R
A
-
I
P
V
P
Y
M
G
------
L
D
I
G
P
K
T
R
E
A
F
A
R
A
L
E
G
A
R
T
V
F
W
N
G
P
M
G
V
F
E
V
P
P
F
D
E
G
T
L
A
V
G
Q
A
I
---
A
----
A
---
L
E--
G
-
A
---
F
T
---
V
V
G
G
G
D
S
V
A
A
V
N
R
L
G
L
K
E
R
F
G
H
V
S
T
G
G
G
A
S
L
E
F
L
E
K
G
T
L
P
G
L
E
V
L
E
G
----
12
PsiBlast_PDB
82.38
41%
-104
- C9 -
3Q3V
5
PGK_CAMJE
A:
[7-399]
--
I
I
S
I
K
--
D
I
-
D
L
A
K
K
K
V
F
I
R
C
D
F
N
V
P
Q
D
D
-
F
L
N
I
T
D
D
R
R
I
R
S
A
I
P
T
I
R
Y
C
L
D
N
G
C
-
S
-
V
I
L
A
S
H
L
G
R
P
-------------
K
E
----
I
S
S
K
Y
S
L
E
P
V
A
K
R
L
A
R
L
L
D
K
E
I
V
M
A
----
K
D
V
I
G
E
D
A
K
T
K
A
-------
M
------
N
L
-------
K
-------
A
-------
G
E
I
L
L
L
E
N
L
R
F
E
---------------
K
--
G
E
T
K
--------------
N
-------
D
--
E
N
-----
L
A
K
E
L
A
----------
S
--------------
M
V
Q
V
Y
I
N
D
A
F
G
V
C
H
R
A
H
S
S
V
E
A
I
T
K
F
F
D
E
K
H
--
K
G
A
G
F
L
L
Q
K
E
I
D
F
A
S
N
L
I
K
H
P
A
R
P
F
V
A
V
V
G
G
S
K
V
S
G
K
L
Q
A
L
T
N
L
--
L
P
K
--
V
D
K
L
I
I
G
G
G
M
A
F
T
F
L
K
A
-
L
-
G
Y
-
D
I
G
N
S
L
L
E
-------
E
-------
E
L
L
E
--
E
--
A
-----
N
K
I
L
T
-----
K
G
K
N
L
G
V
--
K
--
I
Y
L
P
V
D
V
V
A
A
-------
P
A
C
S
Q
D
---
V
-
P
-
M
-
K
F
-
V
P
A
Q
E
-
I
P
N
G
W
M
G
------
L
D
I
G
P
A
S
V
R
L
F
K
E
V
I
S
D
A
Q
T
I
W
W
N
G
P
M
G
V
F
E
I
D
K
F
S
K
G
S
I
K
M
S
H
Y
I
---
S
----
E
---
G
---
H
-
A
---
T
S
---
V
V
G
G
G
D
T
A
D
V
V
A
R
A
G
D
A
D
E
M
T
F
I
S
T
G
G
G
A
S
L
E
L
I
E
G
K
E
L
P
G
V
K
A
L
R
S
----
11
PsiBlast_PDB
81.93
40%
-103
- C9 -
13PK
5
PGKC_TRYBB
A:
[5-415]
-----
I
N
--
E
C
-
D
L
K
G
K
K
V
L
I
R
V
D
F
N
V
P
V
K
N
-
G
-
K
I
T
N
D
Y
R
I
R
S
A
L
P
T
L
K
K
V
L
T
E
G
G
-
S
-
C
V
L
M
S
H
L
G
R
P
K
G
I
P
M
A
Q
A
G
K
I
R
S
T
G
G
VP
G
F
Q
Q
K
A
T
L
K
P
V
A
K
R
L
S
E
L
L
L
R
P
V
T
F
A
----
P
D
C
L
------
N
A
-------
A
------
D
V
V
S
K
M---
S
-------
P
-------
G
D
V
V
L
L
E
N
V
R
F
Y
---------------
K
EE
G
S
K
K
--------------
A
-------
K
--
D
R
E
A
---
M
A
K
I
L
A
----------
S
--------------
Y
G
D
V
Y
I
S
D
A
F
G
T
A
H
R
D
S
A
T
M
T
G
I
P
K
I
--
L
G
N
--
G
A
A
G
Y
L
M
E
K
E
I
S
Y
F
A
K
V
L
G
N
P
P
R
P
L
V
A
I
V
G
G
A
K
V
S
D
K
I
Q
L
L
D
N
M
--
L
Q
R
--
I
D
Y
L
L
I
G
G
A
M
A
Y
T
F
L
K
A
-
Q
-
G
Y
-
S
I
G
K
S
K
C
E
-------
E
-------
S
K
L
E
--
F
--
A
-----
R
S
L
L
K
K
A
E
D
R
K
-----
V
--
Q
--
V
I
L
P
I
D
H
V
C
H
-------
T
E
F
K
A
V
---
D
-
S
-
P
-
L
I
-
T
E
D
Q
N
-
I
P
E
G
H
M
A
------
L
D
I
G
P
K
T
I
E
K
Y
V
Q
T
I
G
K
C
K
S
A
I
W
N
G
P
M
G
V
F
E
M
V
P
Y
S
K
G
T
F
A
I
A
K
A
M
---
G
R
G
T
H
E
---
H
---
G
-
L
---
M
S
---
I
I
G
G
G
D
S
A
S
A
A
E
L
S
G
E
A
K
R
M
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
T
L
P
G
V
T
V
L
D
D
K
---
41
PsiBlast_CBE
81.90
39%
-109
- C9 -
1VJD
2
PGK1_PIG
A:
[6-415]
---
L
T
L
D
--
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
I
--
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
C
V
-------
G
-------
P
------
E
V
-------
E
K
A
C
ADPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
VEEEG
K
G
K
D
A-----
S
--
G
S
K
V
--------------
K
-------
A
--
D
P
A
K
I
E
A
F
R
A
S
L
S
----------
K
--------------
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
K
K
----
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
S
K
--
I
--
V
-----
K
D
L
M
S
-----
K
A
E
K
N
G
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
N
---
A
-
K
-
T
-
G
Q
-
A
T
V
A
S
G
I
P
A
G
W
M
G
------
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
V
---
42
PsiBlast_CBE
81.06
39%
-107
- C9 -
1VJC
1
PGK1_PIG
A:
[6-415]
---
L
T
L
D
--
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
I
--
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
C
V
-------
G
-------
P
------
E
V
-------
E
K
A
C
ADPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
VEEEG
K
G
K
D
A-----
S
--
G
S
K
V
--------------
K
-------
A
--
D
P
A
K
I
E
A
F
R
A
S
L
S
----------
K
--------------
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
K
K
----
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
S
K
--
I
--
V
-----
K
D
L
M
S
-----
K
A
E
K
N
G
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
N
---
A
-
K
-
T
-
G
Q
-
A
T
V
A
S
G
I
P
A
G
W
M
G
------
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
R
G
C
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
V
---
69
HHSearch
80.95
42%
-105
- C9 -
1QPG
2
PGK_YEAST
A:
[4-414]
-
S
K
L
S
V
Q
--
D
L
-
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
-
K
-
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
Y
V
V
L
A
S
H
L
G
Q
P
-------------
N
-
G
--
E
R
N
E
K
Y
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
T
F
L
----
N
D
C
V
------
G
P
E
V
E
A
A
V
-
K
------
A
S
-------
A
-------
P
-------
G
S
V
I
L
L
E
N
L
R
Y
H
---------------
I
--
E
E
E
G
S
R
K
V
DGQKVKAS
K
E
D
-------
V
--
Q
K
-----
F
R
H
E
L
S
----------
S
--------------
L
A
D
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
----
L
P
Q
--
R
A
A
G
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
--
L
D
K
--
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
-
L
E
N
T
-
E
I
G
D
S
I
F
D
-------
K
-------
A
G
A
E
--
I
--
V
-----
P
K
L
M
E
K
A
K
A
K
G
-----
V
--
E
--
V
V
L
P
V
D
F
I
I
A
-------
D
A
F
S
A
D
---
A
-
N
T
K
-
T
V
-
T
D
K
E
G
-
I
P
A
G
W
Q
G
------
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
---
V
----
K
---
S
S
A
A
G
-
N
---
T
V
---
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
K
--
18
PsiBlast_PDB
80.52
39%
-105
- C9 -
4O3F
2
PGK1_MOUSE
A:
[7-416]
---
L
T
L
D
--
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
V
--
P
M
P
D
K
Y
S
L
E
P
V
A
A
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
C
V
-------
G
-------
P
------
E
V
-------
E
N
A
C
ANPA
A
-------
G
T
V
I
L
L
E
N
L
R
F
H
VEEEG
K
G
K
D
ASG
N
K
V
K
--
A
E
P
A
--------------
K
-------
I
--
D
A
-----
F
R
A
S
L
S
----------
K
--------------
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
K
----
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
Y
D
-------
E
-------
E
G
A
K
--
I
--
V
-----
K
D
L
M
S
-----
K
A
E
K
N
G
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
N
---
A
-
K
-
T
-
G
Q
-
A
T
V
A
S
G
I
P
A
G
W
M
G
------
L
D
C
G
T
E
S
S
K
K
Y
A
E
A
V
G
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
S
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
--------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
V
---
48
PsiBlast_CBE
80.50
41%
-108
- C9 -
1QPG
2
PGK_YEAST
A:
[6-414]
---
L
S
V
Q
--
D
L
-
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
-
K
-
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
Y
V
V
L
A
S
H
L
G
Q
P
-------------
N
-
G
--
E
R
N
E
K
Y
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
T
F
L
----
N
D
C
V
-------
G
-------
P
------
E
V
-------
E
-------
A
A
V
K
A
SAP
G
S
V
I
L
L
E
N
L
R
Y
H
IEEEG
S
R
K
V
DGQKV-
K
--
A
S
K
E
--------------
D
-------
V
--
Q
K
-----
F
R
H
E
L
S
----------
S
--------------
L
A
D
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
L
P
--
Q
R
----
A
A
G
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
--
L
D
K
--
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
L
E
-
N
T
-
E
I
G
D
S
I
F
D
K
A
G
----
A
-------
E
I
V
P
K
L
M
--
E
-----
K
A
K
A
K
-----
G
-----
V
--
E
--
V
V
L
P
V
D
F
I
I
A
-------
D
A
F
--
S
---
A
-
D
-
A
-
N
T
-
K
T
----
V
T
D
K
E
G
I
PAGWQG
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
---
V
----
K
---
S
---
S
-
A
---
A
G
N
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
K
--
43
PsiBlast_CBE
79.63
39%
-100
- C9 -
1KF0
3
PGK1_PIG
A:
[6-415]
---
L
T
L
D
--
K
L
-
N
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
D
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
S
--
P
M
P
D
K
Y
S
L
Q
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
C
V
-------
G
-------
P
------
E
V
-------
E
K
A
C
ADPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
V--------------
E
--
E
E
G
K
--------------
G
-------
K
--
D
A
-----
S
G
N
K
V
K
----------
A
E
P
A
K
I
K
T
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
K
K
----
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
--
I
--
V
-----
K
N
L
M
S
-----
K
A
E
K
N
G
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
H
---
A
-
K
-
T
-
G
Q
-
A
T
V
A
S
G
I
P
A
G
W
M
G
------
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
R
G
C
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
V
---
29
PsiBlast_CBE
79.54
39%
-98
- C9 -
3ZOZ
5
PGK1_HUMAN
A:
[7-416]
---
L
T
L
D
--
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
V
--
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
C
V
-------
G
-------
P
------
E
V
-------
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
V--------------
E
--
E
E
G
K
--------------
G
----------------------------------EP
A
K
I
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
K
----
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
--
I
--
V
-----
K
D
L
M
S
-----
K
A
E
K
N
G
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
N
---
A
-
K
-
T
-
G
Q
-
A
T
V
A
S
G
I
P
A
G
W
M
G
------
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
---
64
HHSearch
79.02
40%
-99
- C9 -
2WZB
5
PGK1_HUMAN
A:
[3-415]
S
N
K
L
T
L
D
--
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-------------
D
G
V
--
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
C
V
------
G
P
E
V
E
K
A
C
-
A
------
N
P
-------
A
-------
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
--
E
E
E
G
KGE
P
A
---------
K
-------
I
--
E
A
-----
F
R
A
S
L
S
----------
K
--------------
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
N
N
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
--
I
--
V
-----
K
D
L
M
S
K
A
E
K
N
G
-----
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
N
---
A
-
K
T
G
-
Q
A
-
T
V
A
S
G
-
I
P
A
G
W
M
G
------
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
T
S
R
G
-
C
---
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
---
31
PsiBlast_CBE
78.82
39%
-99
- C9 -
2XE8
2
PGK1_HUMAN
A:
[7-416]
---
L
T
L
D
--
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
V
--
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
C
V
-------
G
-------
P
------
E
V
-------
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
V--------------
E
--
E
E
G
K
--------------
G
-------
K
--
D
A
-----
S
G
N
K
V
K
----------
A
E
P
A
K
I
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
K
----
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
--
I
--
V
-----
K
D
L
M
S
-----
K
A
E
K
N
G
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
N
---
A
-
K
-
T
-
G
Q
-
A
T
V
A
S
G
I
P
A
G
W
M
G
------
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
---
19
PsiBlast_PDB
78.80
39%
-99
- C9 -
2XE6
1
PGK1_HUMAN
A:
[7-416]
---
L
T
L
D
--
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
V
--
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
C
V
-------
G
-------
P
------
E
V
-------
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
V--------------
E
--
E
E
G
K
--------------
G
-------
K
--
D
A
-----
S
G
N
K
V
K
----------
A
E
P
A
K
I
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
K
----
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
--
I
--
V
-----
K
D
L
M
S
-----
K
A
E
K
N
G
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
N
---
A
-
K
-
T
-
G
Q
-
A
T
V
A
S
G
I
P
A
G
W
M
G
------
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
---
44
PsiBlast_CBE
78.77
39%
-99
- C9 -
4O33
2
PGK1_HUMAN
A:
[7-416]
---
L
T
L
D
--
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
V
--
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
C
V
-------
G
-------
P
------
E
V
-------
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
V--------------
E
--
E
E
G
K
--------------
G
-------
K
--
D
A
-----
S
G
N
K
V
K
----------
A
E
P
A
K
I
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
K
----
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
--
I
--
V
-----
K
D
L
M
S
-----
K
A
E
K
N
G
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
N
---
A
-
K
-
T
-
G
Q
-
A
T
V
A
S
G
I
P
A
G
W
M
G
------
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
R
GC
I
T
---
T
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
---
16
PsiBlast_PDB
78.70
39%
-100
- C9 -
2X15
3
PGK1_HUMAN
A:
[6-415]
---
L
T
L
D
--
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
V
--
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
C
V
-------
G
-------
P
------
E
V
-------
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
V--------------
E
--
E
E
G
K
--------------
G
-------
K
--------------
K
----------
A
E
P
A
K
I
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
K
----
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
--
I
--
V
-----
K
D
L
M
S
-----
K
A
E
K
N
G
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
N
---
A
-
K
-
T
-
G
Q
-
A
T
V
A
S
G
I
P
A
G
W
M
G
------
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
---
14
PsiBlast_PDB
78.63
39%
-100
- C9 -
2WZC
5
PGK1_HUMAN
A:
[6-415]
---
L
T
L
D
--
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
V
--
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
C
V
-------
G
-------
P
------
E
V
-------
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
V--------------
E
--
E
E
G
K
--------------
G
----------------------------------E
P
A
K
I
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
K
----
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
--
I
--
V
-----
K
D
L
M
S
-----
K
A
E
K
N
G
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
N
---
A
-
K
-
T
-
G
Q
-
A
T
V
A
S
G
I
P
A
G
W
M
G
------
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
---
51
PsiBlast_CBE
78.62
38%
-102
- C9 -
2P9T
1
PGK2_MOUSE
A:
[6-415]
---
L
T
L
D
--
K
V
-
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
I
--
P
M
P
D
K
Y
S
L
E
P
V
A
D
E
L
K
S
L
L
N
K
D
V
I
F
L
----
K
D
C
V
-------
G
-------
P
------
E
V
-------
E
-------
Q
A
C
ANPDN
G
S
I
I
L
L
E
N
L
R
F
H
V--------------
E
--
E
E
G
K
--------------
G
-------
K
--
D
S
-----
S
G
K
K
I
S
----------
A
D
P
A
K
V
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
K
----
A
S
G
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
--
L
D
K
--
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
-
L
-
K
N
M
Q
I
G
A
S
L
F
D
-------
E
-------
E
G
A
T
--
I
--
V
-----
K
E
I
M
E
-----
K
A
E
K
N
G
V
--
K
--
I
V
F
P
V
D
F
V
T
G
-------
D
K
F
D
E
N
---
A
K
V
-
G
-
Q
A
-
T
I
E
S
G
-
I
P
S
G
W
M
G
------
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
V
K
A
T
----
S
---
N
---
G
-
C
---
V
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
G
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
N
M
---
56
PsiBlast_CBE
78.58
34%
-103
- C9 -
2CUN
5
PGK_PYRHO
A:
[1-399]
--
M
F
R
L
E
--
D
F
-
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
K
D
-
G
-
K
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
-
K
-
V
V
I
G
T
H
Q
G
K
P
-------------
Y
S
E
--
D
Y
T
---
T
T
E
E
H
A
R
V
L
S
E
L
L
D
Q
H
V
E
Y
I
----
E
D
I
F
------
G
R
-------
Y
A
R
E
K
I
K
E
L
-------
K
-------
S
-------
G
E
V
A
I
L
E
N
L
R
F
S
---------------
A
--
E
E
V
K
--------------
N
-------
K
P
I
E
E
C
E
K
T
F
L
V
K
K
L
S
----------
K
--------------
V
I
D
Y
V
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
A
R
I
---
K
P
--
M
I
M
G
F
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
E
N
V
L
R
R
E
R
--
A
D
L
V
L
T
G
G
L
V
A
N
V
F
T
L
A
-
K
-
G
F
-
D
L
G
R
K
N
V
E
F
M
K
K
K
GL
L
-------
D
Y
V
K
--
H
--
A
-----
E
E
I
L
D
-----
E
-----
F
--
Y
PY
I
R
T
P
V
D
F
A
V
D
-------
Y
K
G
E
R
V
---
E
-
I
-
D
-
L
L
-
S
E
N
R
G
-
L
L
H
Q
Y
Q
I
------
M
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
V
E
V
F
K
A
I
---
A
----
D
---
S
---
P
-
A
---
F
S
---
V
L
G
G
G
H
S
I
A
S
I
Q
K
Y
G
I
T
G
-
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
Q
I
S
Y
E
K
13
PsiBlast_PDB
78.27
39%
-100
- C9 -
2WZB
5
PGK1_HUMAN
A:
[6-415]
---
L
T
L
D
--
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
V
--
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
C
V
-------
G
-------
P
------
E
V
-------
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
V--------------
E
--
E
E
G
K
--------------
G
----------------------------------E
P
A
K
I
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
K
----
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
--
I
--
V
-----
K
D
L
M
S
-----
K
A
E
K
N
G
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
N
---
A
-
K
-
T
-
G
Q
-
A
T
V
A
S
G
I
P
A
G
W
M
G
------
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
---
46
PsiBlast_CBE
78.11
39%
-99
- C9 -
2WZD
5
PGK1_HUMAN
A:
[7-416]
---
L
T
L
D
--
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
V
--
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
C
V
-------
G
-------
P
------
E
V
-------
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
V--------------
E
--
E
E
G
K
--------------
G
----------------------------------E
P
A
K
I
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
K
----
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
A
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
--
I
--
V
-----
K
D
L
M
S
-----
K
A
E
K
N
G
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
N
---
A
-
K
-
T
-
G
Q
-
A
T
V
A
S
G
I
P
A
G
W
M
G
------
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
---
39
PsiBlast_CBE
78.01
39%
-103
- C9 -
3C39
1
PGK1_HUMAN
A:
[10-419]
---
L
T
L
D
--
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
V
--
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
C
V
-------
G
-------
P
------
E
V
-------
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
V--------------
E
--
E
E
G
K
--------------
G
-------
K
--------------
K
----------
A
E
P
A
K
I
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
K
----
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
--
I
--
V
-----
K
D
L
M
S
-----
K
A
E
K
N
G
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
N
---
A
-
K
-
T
-
G
Q
-
A
T
V
A
S
G
I
P
A
G
W
M
G
------
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
---
50
PsiBlast_CBE
77.95
38%
-104
- C9 -
2PAA
1
PGK2_MOUSE
A:
[6-415]
---
L
T
L
D
--
K
V
-
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
I
--
P
M
P
D
K
Y
S
L
E
P
V
A
D
E
L
K
S
L
L
N
K
D
V
I
F
L
----
K
D
C
V
-------
G
-------
P
------
E
V
-------
E
-------
Q
A
C
ANPDN
G
S
I
I
L
L
E
N
L
R
F
H
V--------------
E
--
E
E
G
K
--------------
G
-------
K
--
D
S
-----
S
G
K
K
I
S
----------
A
D
P
A
K
V
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
K
----
A
S
G
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
--
L
D
K
--
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
-
L
-
K
N
M
Q
I
G
A
S
L
F
D
-------
E
-------
E
G
A
T
--
I
--
V
-----
K
E
I
M
E
-----
K
A
E
K
N
G
V
--
K
--
I
V
F
P
V
D
F
V
T
G
-------
D
K
F
D
E
N
---
A
K
V
-
G
-
Q
A
-
T
I
E
S
G
-
I
P
S
G
W
M
G
------
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
V
K
A
T
----
S
---
N
---
G
-
C
---
V
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
G
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
N
M
---
55
PsiBlast_CBE
77.81
34%
-101
- C9 -
2CUN
5
PGK_PYRHO
B:
[1-399]
--
M
F
R
L
E
--
D
F
-
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
K
D
-
G
-
K
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
-
K
-
V
V
I
G
T
H
Q
G
K
P
-------------
Y
S
E
--
D
Y
T
---
T
T
E
E
H
A
R
V
L
S
E
L
L
D
Q
H
V
E
Y
I
----
E
D
I
F
------
G
R
-------
Y
AREKIK
E
L
-------
K
-------
S
-------
G
E
V
A
I
L
E
N
L
R
F
S
---------------
A
--
E
E
V
K
--------------
N
-------
K
PI
E
E
CEKTF
L
V
K
K
L
S
----------
K
--------------
V
I
D
Y
V
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
A
R
I
---
K
P
--
M
I
M
G
F
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
E
N
V
LR
R
E
R
--
A
D
L
V
L
T
G
G
L
V
A
N
V
F
T
L
A
-
K
-
G
F
-
D
L
G
R
K
N
V
E
FMKKKGL
L
-------
D
Y
V
K
--
H
--
A
-----
E
E
I
L
D
-----
E
-----
F
--
Y
PY
I
R
T
P
V
D
F
A
V
D
-------
Y
K
G
E
R
V
---
E
-
I
-
D
-
L
L
-
S
E
N
R
G
-
L
L
H
Q
Y
Q
I
------
M
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
V
E
V
F
K
A
I
---
A
----
D
---
S
---
P
-
A
---
F
S
---
V
L
G
G
G
H
S
I
A
S
I
Q
K
Y
G
I
T
G
-
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
Q
I
S
Y
E
K
45
PsiBlast_CBE
77.77
39%
-98
- C9 -
2X14
3
PGK1_HUMAN
A:
[6-415]
---
L
T
L
D
--
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
V
--
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
C
V
-------
G
-------
P
------
E
V
-------
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
V--------------
E
--
E
E
G
K
--------------
G
----------------------------------E
P
A
K
I
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
K
----
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
A
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
--
I
--
V
-----
K
D
L
M
S
-----
K
A
E
K
N
G
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
N
---
A
-
K
-
T
-
G
Q
-
A
T
V
A
S
G
I
P
A
G
W
M
G
------
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
---
40
PsiBlast_CBE
77.42
39%
-103
- C9 -
2ZGV
1
PGK1_HUMAN
A:
[10-419]
---
L
T
L
D
--
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
V
--
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
C
V
-------
G
-------
P
------
E
V
-------
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
V--------------
E
--
E
E
G
K
--------------
G
-------
K
--
D
A
-----
S
G
N
K
V
K
----------
A
E
P
A
K
I
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
K
----
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
--
I
--
V
-----
K
D
L
M
S
-----
K
A
E
K
N
G
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
N
---
A
-
K
-
T
-
G
Q
-
A
T
V
A
S
G
I
P
A
G
W
M
G
------
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
------------
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
---
67
HHSearch
77.38
37%
-96
- C9 -
2CUN
5
PGK_PYRHO
A:
[1-402]
--
M
F
R
L
E
--
D
F
-
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
K
D
-
G
-
K
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
-
K
-
V
V
I
G
T
H
Q
G
K
P
-------------
Y
-
S
----
E
D
Y
T
T
T
E
E
H
A
R
V
L
S
E
L
L
D
Q
H
V
E
Y
I
----
E
D
I
F
------
G
R
Y
A
R
E
K
I
-
K
------
E
L
-------
K
-------
S
-------
G
E
V
A
I
L
E
N
L
R
F
S
---------------
A
--
E
E
V
K
--------------
N
K
P
I
E
E
C
E
K
--
T
F
-----
L
V
K
K
L
S
----------
K
--------------
V
I
D
Y
V
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
A
R
I
--
K
P
---
M
I
M
G
F
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
E
N
V
--
L
R
R
ER
A
D
L
V
L
T
G
G
L
V
A
N
V
F
T
L
A
-
K
-
G
F
-
D
L
G
R
K
N
V
E
-------
F
M
K
K
K
GLL
D
Y
V
K
--
H
--
A
-----
E
E
I
L
D
-----
E
FY---
P
--
Y
--
I
R
T
P
V
D
F
A
V
D
-------
Y
K
G
E
R
V
---
E
-
I
-
D
-
L
L
-
S
E
N
R
G
-
L
L
H
Q
Y
Q
I
------
M
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
V
E
V
F
K
A
I
---
A
----
D
---
S
---
P
-
A
---
F
S
---
V
L
G
G
G
H
S
I
A
S
I
Q
K
Y
G
I
-
T
G
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
Q
I
S
Y
E
K
20
PsiBlast_PDB
77.14
39%
-96
- C9 -
2XE7
2
PGK1_HUMAN
A:
[7-416]
---
L
T
L
D
--
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
V
--
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
C
V
-------
G
-------
P
------
E
V
-------
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
V--------------
E
--
E
E
G
K
--------------
G
-------
K
--
D
A
-----
S
G
N
K
V
K
----------
A
E
P
A
K
I
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
K
----
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
--
I
--
V
-----
K
D
L
M
S
-----
K
A
E
K
N
G
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
N
---
A
-
K
-
T
-
G
Q
-
A
T
V
A
S
G
I
P
A
G
W
M
G
------
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
---
49
PsiBlast_CBE
77.09
38%
-106
- C9 -
2PAA
1
PGK2_MOUSE
B:
[6-415]
---
L
T
L
D
--
K
V
-
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
I
--
P
M
P
D
K
Y
S
L
E
P
V
A
D
E
L
K
S
L
L
N
K
D
V
I
F
L
----
K
D
C
V
-------
G
-------
P
------
E
V
-------
E
-------
Q
ACANPDN
G
S
I
I
L
L
E
N
L
R
F
H
V--------------
E
--
E
E
G
K
--------------
G
-------
K
--
D
S
-----
S
G
K
K
I
S
----------
A
DPAKVEAFRASLSK
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
K
----
A
S
G
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
--
L
D
K
--
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
-
L
-
K
N
M
Q
I
G
A
S
L
F
D
-------
E
-------
E
G
A
T
--
I
--
V
-----
K
E
I
M
E
-----
K
AEKNG
V
--
K
--
I
V
F
P
V
D
F
V
T
G
-------
D
K
F
D
E
N
---
A
K
V
-
G
-
Q
A
-
T
I
E
S
G
-
I
P
S
G
W
M
G
------
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
VKA
T
----
S
---
N
---
G
-
C
---
V
T
---
I
I
G
---------------
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
N
M
---
15
PsiBlast_PDB
76.85
39%
-97
- C9 -
2X13
3
PGK1_HUMAN
A:
[6-415]
---
L
T
L
D
--
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
V
--
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
C
V
-------
G
-------
P
------
E
V
-------
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
V--------------
E
--
E
E
G
K
--------------
G
-------
K
--------------
K
----------
A
E
P
A
K
I
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
K
----
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
--
I
--
V
-----
K
D
L
M
S
-----
K
A
E
K
N
G
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
N
---
A
-
K
-
T
-
G
Q
-
A
T
V
A
S
G
I
P
A
G
W
M
G
------
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
---
37
PsiBlast_CBE
76.83
39%
-101
- C9 -
3C3A
1
PGK1_HUMAN
A:
[10-419]
---
L
T
L
D
--
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
V
--
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
C
V
-------
G
-------
P
------
E
V
-------
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
V--------------
E
--
E
E
G
K
--------------
G
-------
K
--
D
A
-----
S
G
N
K
V
K
----------
A
E
P
A
K
I
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
K
----
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
--
I
--
V
-----
K
D
L
M
S
-----
K
A
E
K
N
G
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
N
---
A
-
K
-
T
-
G
Q
-
A
T
V
A
S
G
I
P
A
G
W
M
G
------
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
R
G
C
I
T
---
I
I
G
G
---------
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
---
34
PsiBlast_CBE
76.60
39%
-103
- C9 -
3C3B
2
PGK1_HUMAN
B:
[10-419]
---
L
T
L
D
--
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
V
--
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
C
V
-------------------------------
E
KACANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
V--------------
E
--
E
E
G
K
--------------
G
-------
K
--
D
A
-----
S
G
N
K
V
K
----------
A
E
P
A
K
I
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
K
----
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
--
I
--
V
-----
K
D
L
M
S
-----
K
A
E
K
N
G
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
N
---
A
-
K
-
T
-
G
Q
-
A
T
V
A
S
G
I
P
A
G
W
M
G
------
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
R
G
C
I
T
---
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
---
17
PsiBlast_PDB
76.47
39%
-93
- C9 -
2Y3I
5
PGK1_HUMAN
A:
[7-416]
---
L
T
L
D
--
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
V
--
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
C
V
-------
G
-------
P
------
E
V
-------
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
V--------------
E
--
E
E
G
K
--------------
G
-------
K
--
D
A
-----
S
G
N
K
V
K
----------
A
E
P
A
K
I
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
K
----
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
--
I
--
V
-----
K
D
L
M
S
-----
K
A
E
K
N
G
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
N
---
A
-
K
-
T
-
G
Q
-
A
T
V
A
S
G
I
P
A
G
W
M
G
------
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
R
G
C
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
----
33
PsiBlast_CBE
76.45
39%
-101
- C9 -
3C3C
3
PGK1_HUMAN
A:
[10-419]
---
L
T
L
D
--
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
V
--
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
C
V
-------
G
-------
P
------
E
V
-------
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
V--------------
E
--
E
E
G
K
--------------
G
-------
K
--
D
A
-----
S
G
N
K
V
K
----------
A
E
P
A
K
I
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
K
----
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
--
I
--
V
-----
K
D
L
M
S
-----
K
A
E
K
N
G
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
N
---
A
-
K
-
T
-
G
Q
-
A
T
V
A
S
G
I
P
A
G
W
M
G
------
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
R
G
C
I
T
---
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
---
36
PsiBlast_CBE
76.18
39%
-100
- C9 -
3C3A
3
PGK1_HUMAN
B:
[10-419]
---
L
T
L
D
--
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
V
--
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
C
V
--------------------------------KACANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
V--------------
E
--
E
E
G
K
--------------
G
-------
K
--
D
A
-----
S
G
N
K
V
K
----------
A
E
P
A
K
I
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
K
----
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
--
I
--
V
-----
K
D
L
M
S
-----
K
A
E
K
N
G
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
N
---
A
-
K
-
T
-
G
Q
-
A
T
V
A
S
G
I
P
A
G
W
M
G
------
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
------------
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
---
52
PsiBlast_CBE
75.92
38%
-105
- C9 -
1HDI
3
PGK1_PIG
A:
[3-412]
---
L
T
L
D
--
K
L
-
N
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
A
A
-
A
-
Q
I
T
N
N
A
R
I
K
A
A
V
P
S
I
K
F
C
L
D
D
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
S
--
P
M
P
D
K
Y
S
L
Q
P
V
A
A
E
L
K
S
A
L
G
K
A
V
L
F
L
----
K
D
C
V
------
G
P
-------
A
------
V
E
-------
K
-------
A
C
ADPAA-
G
S
V
I
L
L
E
N
L
R
F
H
VEEEG----------
K
--
G
K
D
A
--------------
S
-------
G
--
N
K
-----
A
A
G
E
P
A
K
I
K
A
F
R
A
S
L
S
A
--------------
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
K
K
A
--
G
A
F
--
L
M
K
K
E
L
N
Y
F
A
A
A
A
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
F
D
E
A
G
----
K
-------
K
I
V
K
--
N
L
M
S
-----
K
A
A
A
N
-----
G
-----
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
Q
---
A
K
I
-
G
-
Q
A
-
T
V
A
S
G
-
I
P
A
G
W
M
G
------
L
D
C
G
P
K
S
S
A
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
N
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
V
---
28
PsiBlast_CBE
75.90
39%
-99
- C9 -
4AXX
5
PGK1_HUMAN
A:
[7-416]
---
L
T
L
D
--
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
V
--
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
C
V
-------
G
-------
P
------
E
V
-------
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
V--------------
E
--
E
E
G
K
--------------
G
-------
K
-------------------------
A
E
P
A
K
I
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
K
----
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
--
I
--
V
-----
K
D
L
M
S
-----
K
A
E
K
N
G
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
N
---
A
-
K
-
T
-
G
Q
-
A
T
V
A
S
G
I
P
A
G
W
M
G
------
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
---
38
PsiBlast_CBE
75.66
39%
-98
- C9 -
3C39
1
PGK1_HUMAN
B:
[10-419]
---
L
T
L
D
--
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
V
--
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
---------------------------------
E
KACANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
V--------------
E
--
E
E
G
K
--------------
G
-------
K
--
D
A
-----
S
G
N
K
V
K
----------
A
E
P
A
K
I
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
K
----
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
--
I
--
V
-----
K
D
L
M
S
-----
K
A
E
K
N
G
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
N
---
A
-
K
-
T
-
G
Q
-
A
T
V
A
S
G
I
P
A
G
W
M
G
------
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
R
G
C
I
T
---
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
---
27
PsiBlast_CBE
75.14
39%
-93
- C9 -
2Y3I
5
PGK1_HUMAN
D:
[7-416]
---
L
T
L
D
--
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
V
--
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
C
V
-------
G
-------
P
------
E
V
-------
E
KACANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
V--------------
E
--
E
E
G
K
--------------
G
-------
K
--
D
A
-----
S
G
N
K
V
K
----------
A
EPAKIEAFRASLSK
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
K
----
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
--
I
--
V
-----
K
D
L
M
S
-----
K
AEKNG
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
N
---
A
-
K
-
T
-
G
Q
-
A
T
V
A
S
G
I
P
A
G
W
M
G
------
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
RGC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
----
32
PsiBlast_CBE
75.04
39%
-100
- C9 -
3C3C
1
PGK1_HUMAN
B:
[10-419]
---
L
T
L
D
--
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
V
--
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
C
V
-------------------------------
E
KACANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
V--------------
E
--
E
E
G
K
--------------
G
-------
K
--
D
A
-----
S
G
N
K
V
K
----------
A
E
P
A
K
I
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
K
----
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
--
I
--
V
-----
K
D
L
M
S
-----
K
A
E
K
N
G
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
N
---
A
-
K
-
T
-
G
Q
-
A
T
V
A
S
G
I
P
A
G
W
M
G
------
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
R
G
C
I
T
---
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
---
30
PsiBlast_CBE
74.92
39%
-98
- C9 -
2YBE
5
PGK1_HUMAN
A:
[7-416]
---
L
T
L
D
--
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
S
H
L
G
R
P
-------------
D
G
V
--
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
----
K
D
C
V
-------
G
-------
P
------
E
V
-------
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
V--------------
E
--
E
E
G
K
--------------
G
-------
K
------------
K
V
K
----------
A
E
P
A
K
I
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
K
----
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
--
I
--
V
-----
K
D
L
M
S
-----
K
A
E
K
N
G
V
--
K
--
I
T
L
P
V
D
F
V
T
A
-------
D
K
F
D
E
N
---
A
-
K
-
T
-
G
Q
-
A
T
V
A
S
G
I
P
A
G
W
M
G
------
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
----
K
---
A
---
T
-
S
R
G
C
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
---
70
HHSearch
66.59
39%
-95
- C9 -
1FW8
5
PGK_YEAST
A:
[1-344]
-------------------------------------------------------------------------------------------
S
K
Y
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
T
F
L
----
N
D
C
V
------
G
P
E
V
E
A
A
V
-
K
------
A
S
-------
A
-------
P
-------
G
S
V
I
L
L
E
N
L
R
Y
H
---------------
I
--
E
E
E
G
S
R
K
V
DG
Q
K
V
K
A
S
K
E
D
-------
V
--
Q
K
-----
F
R
H
E
L
S
----------
S
--------------
L
A
D
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
----
L
P
Q
--
R
A
A
G
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
--
L
D
K
--
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
-
L
E
N
T
-
E
I
G
D
S
I
F
D
-------
K
-------
A
G
A
E
--
I
--
V
-----
P
K
L
M
E
K
A
K
A
K
G
-----
V
--
E
--
V
V
L
P
V
D
F
I
I
A
-------
D
A
F
S
A
D
---
A
-
N
-
T
K
T
V
-
T
D
K
E
G
-
I
P
A
G
W
Q
G
------
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
---
V
----
K
---
S
S
A
A
G
-
N
---
T
V
---
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
K
S
L
57
PsiBlast_CBE
65.38
39%
-99
- C9 -
1FW8
5
PGK_YEAST
A:
[1-343]
-------------------------------------------------------------------------------------------
S
K
Y
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
T
F
L
----
N
D
C
V
-------
G
-------
P
------
E
V
-------
E
-------
A
A
V
K
A
SAP
G
S
V
I
L
L
E
N
L
R
Y
H
IEEEG
S
R
K
V
DG
Q
K
V
-
K
--
A
S
K
E
--------------
D
-------
V
--
Q
K
-----
F
R
H
E
L
S
----------
S
--------------
L
A
D
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
L
P
--
Q
R
----
A
A
G
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
--
L
D
K
--
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
L
E
-
N
T
-
E
I
G
D
S
I
F
D
K
A
G
----
A
-------
E
I
V
P
K
L
M
--
E
-----
K
A
K
A
K
-----
G
-----
V
--
E
--
V
V
L
P
V
D
F
I
I
A
-------
D
A
F
--
S
---
A
-
D
-
A
-
N
T
-
K
T
----
V
T
D
K
E
G
I
PAGWQG
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
---
V
----
K
---
S
---
S
-
A
---
A
G
N
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
K
S
L
47
PsiBlast_CBE
38.32
40%
1
- C9 -
3PGK
3
PGK_YEAST
A:
[9-415]
---
L
S
V
Q
--
D
L
-
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
-
K
-
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
Y
V
V
L
A
S
H
L
G
R
P
-------------
N
-
G
--
E
R
N
E
K
Y
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
T
F
L
----
N
D
C
V
-------
G
-------
P
------
E
V
-------
E
-------
A
A
V
K
A
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
H
IEEEGSRKV
D
G
Q
K
V
-
K
--
A
S
K
E
--------------
D
-------
V
--
Q
K
-----
F
R
H
E
L
S
----------
S
--------------
L
A
D
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
L
P
--
Q
R
----
A
A
G
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
--
L
D
K
--
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
L
E
-
N
T
-
E
I
G
D
S
I
F
D
K
A
V
G
P
E
I
A
-------
K
L
M
E
--
K
--
A
-----
K
A
K
G
------------
V
--
E
--
V
V
L
P
V
D
F
I
I
A
-------
D
A
F
S
A
S
---
A
N
T
-
K
-
T
V
-
T
D
K
E
G
-
I
P
A
G
W
Q
G
------
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
T
V
I
L
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
---
V
----
K
---
S
---
S
-
A
---
A
G
N
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
K
--
71
HHSearch
35.43
53%
-69
- C9 -
1FW8
2
PGK_YEAST
A:
[349-411]
--
K
L
S
V
Q
--
D
L
-
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
-
K
-
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
Y
V
V
L
A
S
H
L
G
R
P
-------------
N
G
E
--
R
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------