@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0555: (2016-01-09 )
MALISMRQMLDHAAEFGYGVPAFNVNNLEQMRAIMEAADKTDSPVIVQASAGARKYAGAPFLRHLILAAIEEFPHIPVVMHQDHGTSPDVCQRSIQLGFSSVMMDGSLREDGKTPADYDYNVRVTQQTVAFAHACGVSVEGELGCLGSLETGMAGEEDGVGAEGVLDHSQLLTDPEEAADFVKKTKVDALAIAIGTSHGAYKFTKPPTGDTLSIQRIKEIHARIPDTHLVMHGSSSVPQDWLAIINEYGGEIKETYGVPVEEIVEGIKYGVRKVNIDTDLRLASTGAIRRFLAQNPSEFDPRKYFSKTVEAMRDICIARYEAFGTAGNASKIKPISLEGMFQRYARGELDPKVN
Atome Classification :
(27 SA)
.........10........20........30........40........50..-......60........70--...-.-----....80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.........230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
L
I
S
M
R
Q
M
L
D
H
A
A
E
FGYGVPAFNVN
N
L
E
Q
M
R
A
I
M
E
AADKTDS
P
V
I
V
Q
ASAGA-RKYA
G
A
P
F
L
R
H
L
I
L
A
A
I
E
--EFP-H-----I
P
V
V
M
HQDHGT
S
P
D
V
C
Q
R
S
I
Q
L
G
F
S
S
V
MMDGSLREDGKTPADYD
Y
N
V
R
V
T
Q
Q
T
V
A
F
A
H
ACGVSVEGELGCLGSLETGMAGEEDGVGAEGVL
D
H
S
Q
LLT
D
P
E
E
A
A
D
F
V
K
KTKV
D
A
L
A
I
A
I
GTSHGAYKFTKPPTGD
T
L
S
I
Q
R
I
K
E
I
--
H
A
RIPD
T
H
L
V
MHGSSSV
P
Q
D
W
L
A
I
I
N
EYGG
E
I
K
E
TYGV
P
V
E
E
I
V
E
G
I
K
YG
V
R
K
VNIDTD
L
R
LA
S
T
G
A
I
R
R
F
L
AQNPSEF
D
P
R
K
Y
F
S
K
T
V
E
A
M
R
D
I
C
I
A
R
Y
E
AFGTAGNASK
I
K
P
I
S
L
E
G
M
F
Q
R
Y
ARGELDPKVN
116
HHSearch
98.44
48%
-89
- C6 -
2ISW
2
?
A:
[2-322]
-
P
L
C
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
-
L
K
Y
S
D
M
I
Y
L
K
K
L
C
E
A
A
L
E
--
K
H
P
-
D
-----
I
P
I
C
I
H
L
D
H
G
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
H
-------
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
T
L
-----------------------
V
Q
L
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
V
D
A
L
A
V
A
I
G
T
S
H
G
A
Y
K
F
K
S
-----
R
L
A
I
D
R
V
K
T
I
--
S
D
L
-
T
G
I
P
L
V
M
H
G
S
S
S
V
P
K
D
V
K
D
M
I
N
K
Y
G
G
K
M
P
D
A
V
G
V
P
I
E
S
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
K
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
G
D
Y
K
V
V
S
L
E
E
A
K
A
W
Y
----------
3
PsiBlast_PDB
95.42
46%
-89
- C6 -
2ISW
2
?
A:
[2-316]
-
P
L
C
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
-
L
K
Y
S
D
M
I
Y
L
K
K
L
C
E
A
A
L
E
--
K
H
P
-
D
-----
I
P
I
C
I
H
L
D
H
G
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
H
H
P
-------
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
T
L
-----------------------
V
Q
L
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
V
D
A
L
A
V
A
I
G
T
S
H
G
A
Y
K
F
-
K
S
----
R
L
A
I
D
R
V
K
T
I
---
S
D
L
T
G
I
P
L
V
M
H
G
S
S
S
V
P
K
D
V
K
D
M
I
N
K
Y
G
G
K
M
P
D
A
V
G
V
P
I
E
S
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
K
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
G
D
Y
K
V
V
S
L
E
E
A
K
A
W
Y
----------
2
PsiBlast_PDB
95.39
46%
-88
- C6 -
2ISV
2
?
A:
[2-316]
-
P
L
C
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
-
L
K
Y
S
D
M
I
Y
L
K
K
L
C
E
A
A
L
E
--
K
H
P
-
D
-----
I
P
I
C
I
H
L
D
H
G
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
H
H
P
-------
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
---------------------------
L
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
V
D
A
L
A
V
A
I
G
T
S
H
G
A
----------
R
L
A
I
D
R
V
K
T
I
---
S
D
L
T
G
I
P
L
V
M
H
G
S
S
S
V
P
K
D
V
K
D
M
I
N
K
Y
G
G
K
M
P
D
A
V
G
V
P
I
E
S
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
K
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
G
D
Y
K
V
V
S
L
E
E
A
K
A
W
Y
----------
1
PsiBlast_PDB
94.82
47%
-93
- C6 -
3GAK
4
?
A:
[2-316]
-
P
L
C
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
-
L
K
Y
S
D
M
I
Y
L
K
K
L
C
E
A
A
L
E
--
K
H
P
-
D
-----
I
P
I
C
I
H
L
D
H
G
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
H
H
P
-------
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
G
V
S
V
E
A
E
L
G
----------------------------
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
V
D
A
L
A
V
A
I
-----------------
L
A
I
D
R
V
K
T
I
---
S
D
L
T
G
I
P
L
V
M
H
G
S
S
S
V
P
K
D
V
K
D
M
I
N
K
Y
G
G
K
M
P
D
A
V
G
V
P
I
E
S
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
K
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
G
D
Y
K
V
V
S
L
E
E
A
K
A
W
Y
----------
21
PsiBlast_CBE
94.24
47%
-87
- C6 -
3GAK
4
?
B:
[2-316]
-
P
L
C
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
-
L
K
Y
S
D
M
I
Y
L
K
K
L
C
E
A
A
L
E
--
K
H
P
-
D
-----
I
P
I
C
I
H
L
D
H
G
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
H
H
P
-------
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
G
V
S
V
E
A
E
L
G
----------------------------
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
V
D
A
L
A
V
A
I
G
T
S
H
G
A
Y
K
F
-
K
S
E
----
L
A
I
D
R
V
K
T
I
---
S
D
L
T
G
I
P
L
V
M
H
G
S
S
S
V
P
K
D
V
K
D
M
I
N
K
Y
G
G
K
M
P
D
A
V
G
V
P
I
E
S
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
K
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
G
D
Y
K
V
V
S
L
E
E
A
K
A
W
Y
----------
22
PsiBlast_CBE
94.15
46%
-81
- C6 -
2ISV
2
?
B:
[2-316]
-
P
L
C
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
-
L
K
Y
S
D
M
I
Y
L
K
K
L
C
E
A
A
L
E
--
K
H
P
-
D
-----
I
P
I
C
I
H
L
D
H
G
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
H
H
P
-------
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
----------------------
Q
N
T
V
Q
L
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
V
D
A
L
A
V
A
I
G
T
S
H
G
A
Y
K
F
------
I
R
L
A
I
D
R
V
K
T
I
---
S
D
L
T
G
I
P
L
V
M
H
G
S
S
S
V
P
K
D
V
K
D
M
I
N
K
Y
G
G
K
M
P
D
A
V
G
V
P
I
E
S
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
K
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
G
D
Y
K
V
V
S
L
E
E
A
K
A
W
Y
----------
117
HHSearch
89.47
45%
-83
* C6 *
1RVG
8
?
A:
[1-305]
-
M
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
G
A
-
M
K
Y
G
G
-
R
A
L
T
L
M
A
V
E
L
A
K
---
E
A
-
R
-----
V
P
V
A
V
H
L
D
H
G
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
-------
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
----------------
K
D
A
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
K
G
R
P
---
F
I
D
H
A
R
L
E
R
I
--
A
R
L
-
V
P
A
P
L
V
L
H
G
A
S
A
V
P
P
E
L
V
E
R
F
R
A
S
G
G
E
I
G
E
A
A
G
I
H
P
E
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
I
R
E
A
L
N
K
N
P
K
E
F
D
P
R
K
Y
L
G
P
A
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
-------------------------
32
PsiBlast_CBE
86.47
38%
-83
- C6 -
3N9R
4
?
P:
[2-304]
--
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
-
I
K
Y
M
G
I
D
M
A
V
G
M
V
K
I
M
C
E
--
R
Y
P
-
H
-----
I
P
V
A
L
H
L
D
H
G
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
-------
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
--------------------
A
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
E
R
L
Q
E
V
K
------
R
L
T
N
I
P
L
V
L
H
G
A
S
A
I
P
D
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-------------------------
10
PsiBlast_PDB
86.06
38%
-83
- C6 -
3N9R
4
?
A:
[2-304]
--
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
-
I
K
Y
M
G
I
D
M
A
V
G
M
V
K
I
M
C
E
--
R
Y
P
-
H
-----
I
P
V
A
L
H
L
D
H
G
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
-------
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
--------------------
A
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
E
R
L
Q
E
V
K
------
R
L
T
N
I
P
L
V
L
H
G
A
S
A
I
P
D
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-------------------------
30
PsiBlast_CBE
85.71
38%
-82
- C6 -
3N9R
14
?
Z:
[2-304]
--
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
-
I
K
Y
M
G
I
D
M
A
V
G
M
V
K
I
M
C
E
--
R
Y
P
-
H
-----
I
P
V
A
L
H
L
D
H
G
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
-------
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
--------------------
A
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
E
R
L
Q
E
V
K
------
R
L
T
N
I
P
L
V
L
H
G
A
S
A
I
P
D
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-------------------------
36
PsiBlast_CBE
85.68
38%
-86
- C6 -
3C4U
2
ALF_HELPY
B:
[2-304]
--
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
-
I
K
Y
M
G
I
D
M
A
V
G
M
V
K
I
M
C
E
--
R
Y
P
-
H
-----
I
P
V
A
L
H
L
D
H
G
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
-------
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
-------------------------
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
E
R
L
Q
E
V
K
------
R
L
T
N
I
P
L
V
L
H
G
A
S
A
I
P
D
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-------------------------
34
PsiBlast_CBE
85.61
38%
-81
- C6 -
3N9R
4
?
B:
[2-304]
--
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
-
I
K
Y
M
G
I
D
M
A
V
G
M
V
K
I
M
C
E
--
R
Y
P
-
H
-----
I
P
V
A
L
H
L
D
H
G
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
-------
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
--------------------
A
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
E
R
L
Q
E
V
K
------
R
L
T
N
I
P
L
V
L
H
G
A
S
A
I
P
D
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-------------------------
7
PsiBlast_PDB
85.43
38%
-86
- C6 -
3C4U
2
ALF_HELPY
A:
[2-304]
--
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
-
I
K
Y
M
G
I
D
M
A
V
G
M
V
K
I
M
C
E
--
R
Y
P
-
H
-----
I
P
V
A
L
H
L
D
H
G
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
-------
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
-------------------------
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
E
R
L
Q
E
V
K
------
R
L
T
N
I
P
L
V
L
H
G
A
S
A
I
P
D
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-------------------------
35
PsiBlast_CBE
85.38
38%
-80
- C6 -
3C56
3
ALF_HELPY
B:
[2-304]
--
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
-
I
K
Y
M
G
I
D
M
A
V
G
M
V
K
I
M
C
E
--
R
Y
P
-
H
-----
I
P
V
A
L
H
L
D
H
G
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
-------
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
-----------------------
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
E
R
L
Q
E
V
K
------
R
L
T
N
I
P
L
V
L
H
G
A
S
A
I
P
D
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-------------------------
33
PsiBlast_CBE
85.32
38%
-80
- C6 -
3N9R
4
?
K:
[2-304]
--
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
-
I
K
Y
M
G
I
D
M
A
V
G
M
V
K
I
M
C
E
--
R
Y
P
-
H
-----
I
P
V
A
L
H
L
D
H
G
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
-------
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
--------------------
A
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
E
R
L
Q
E
V
K
------
R
L
T
N
I
P
L
V
L
H
G
A
S
A
I
P
D
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-------------------------
31
PsiBlast_CBE
85.27
38%
-80
- C6 -
3N9R
2
?
U:
[2-304]
--
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
-
I
K
Y
M
G
I
D
M
A
V
G
M
V
K
I
M
C
E
--
R
Y
P
-
H
-----
I
P
V
A
L
H
L
D
H
G
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
-------
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
--------------------
A
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
E
R
L
Q
E
V
K
------
R
L
T
N
I
P
L
V
L
H
G
A
S
A
I
P
D
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-------------------------
5
PsiBlast_PDB
85.12
43%
-72
- C6 -
1RVG
8
?
A:
[2-305]
--
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
G
A
-
M
K
Y
G
G
----
R
A
L
T
L
M
A
V
E
L
A
K
E
A
-
R
-----
V
P
V
A
V
H
L
D
H
G
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
-------
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
------
K
----------
D
A
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
K
G
R
P
F
I
D
H
A
R
L
E
R
I
------
A
R
L
V
P
A
P
L
V
L
H
G
A
S
A
V
P
P
E
L
V
E
R
F
R
A
S
G
G
E
I
G
E
A
A
G
I
H
P
E
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
I
R
E
A
L
N
K
N
P
K
E
F
D
P
R
K
Y
L
G
P
A
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
-------------------------
8
PsiBlast_PDB
84.97
38%
-80
- C6 -
3C52
4
ALF_HELPY
A:
[2-304]
--
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
-
I
K
Y
M
G
I
D
M
A
V
G
M
V
K
I
M
C
E
--
R
Y
P
-
H
-----
I
P
V
A
L
H
L
D
H
G
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
-------
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
---------------------
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
E
R
L
Q
E
V
K
------
R
L
T
N
I
P
L
V
L
H
G
A
S
A
I
P
D
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-------------------------
9
PsiBlast_PDB
84.81
38%
-80
- C6 -
3C56
3
ALF_HELPY
A:
[2-304]
--
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
-
I
K
Y
M
G
I
D
M
A
V
G
M
V
K
I
M
C
E
--
R
Y
P
-
H
-----
I
P
V
A
L
H
L
D
H
G
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
-------
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
--------------------
A
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
E
R
L
Q
E
V
K
------
R
L
T
N
I
P
L
V
L
H
G
A
S
A
I
P
D
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-------------------------
29
PsiBlast_CBE
84.54
38%
-80
- C6 -
3N9S
5
?
B:
[2-304]
--
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
-
I
K
Y
M
G
I
D
M
A
V
G
M
V
K
I
M
C
E
--
R
Y
P
-
H
-----
I
P
V
A
L
H
L
D
H
G
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
-------
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
----------------------
A
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
K
L
D
F
E
R
L
Q
E
V
K
------
R
L
T
N
I
P
L
V
L
H
G
A
S
A
I
P
D
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-------------------------
118
HHSearch
82.69
39%
-89
- C6 -
1GVF
11
KBAY_ECOLI
A:
[2-285]
-
S
I
I
S
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
G
T
-
F
K
H
I
A
L
E
E
I
Y
A
L
C
S
A
Y
S
T
---
T
Y
-
N
-----
M
P
L
A
L
H
L
D
H
H
E
S
L
D
D
I
R
R
K
V
H
A
G
V
R
S
A
M
I
D
G
S
H
-------
F
P
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
---------------------
S
A
F
L
T
D
P
Q
E
A
K
R
F
V
E
L
T
G
V
D
S
L
A
V
A
I
G
T
A
H
G
L
Y
S
K
--
T
P
---
K
I
D
F
Q
R
L
A
E
I
--
R
E
V
-
V
D
V
P
L
V
L
H
G
A
S
---------------------
D
V
P
D
E
F
V
R
R
T
I
E
L
G
V
T
K
V
N
V
A
T
E
L
K
I
A
F
A
G
A
V
K
A
W
F
A
E
N
P
Q
G
N
D
P
R
Y
Y
M
R
V
G
M
D
A
M
K
E
V
V
R
N
K
I
N
V
C
G
S
A
N
R
I
S
------------------------
6
PsiBlast_PDB
82.36
41%
-71
- C6 -
2FJK
1
ALF_THECA
A:
[2-305]
--
L
V
T
G
L
E
I
L
R
K
A
R
A
E
G
Y
G
V
G
A
F
N
T
N
N
M
E
F
T
Q
A
I
L
E
A
A
E
E
M
K
S
P
V
I
L
A
L
S
E
G
A
-
M
K
Y
G
G
R
A
L
T
R
M
V
V
--
A
L
A
--
Q
E
A
-
R
-----
V
P
V
A
V
H
L
D
H
G
S
S
Y
E
S
V
L
K
A
L
R
E
G
F
T
S
V
M
I
D
-------
K
S
H
E
D
F
E
T
N
V
R
E
T
K
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
H
V
A
V
D
E
K
----------
D
A
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
K
G
R
P
F
I
D
H
P
R
L
A
R
I
------
A
K
L
V
P
A
P
L
V
L
H
G
A
S
A
V
P
Q
E
L
V
E
R
F
R
A
A
G
G
E
I
G
E
A
S
G
I
H
P
E
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
V
R
E
T
L
G
K
N
P
K
E
F
D
P
R
K
Y
L
G
P
A
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
-------------------------
11
PsiBlast_PDB
82.18
35%
-86
- C6 -
4TO8
2
?
A:
[2-285]
-
P
L
V
S
M
K
E
M
L
I
D
A
K
E
N
G
Y
A
V
G
Q
Y
N
I
N
N
L
E
F
T
Q
A
I
L
E
A
S
Q
E
E
N
A
P
V
I
L
G
V
S
E
G
A
-
A
R
Y
M
S
G
F
Y
---
T
I
V
K
M
V
E
--
G
L
M
-
H
D
L
NIT
I
P
V
A
I
H
L
D
H
G
S
S
F
E
K
C
K
E
A
I
D
A
G
F
T
S
V
M
I
D
A
S
-----
H
S
P
--
F
E
E
N
V
A
T
T
K
K
V
V
E
Y
A
H
E
K
G
V
S
V
E
A
E
L
G
T
V
G
-------
G
--
D
D
V
V
A
D
G
I
-----
I
Y
A
D
P
K
E
C
Q
E
L
V
E
K
T
G
I
D
A
L
A
P
A
L
G
S
V
H
G
------
P
----
K
L
G
F
K
E
M
E
E
I
G
L
S
T
G
L
P
---
L
V
L
H
G
G
T
---------------------
G
I
P
T
K
D
I
Q
K
A
I
P
F
G
T
A
K
I
N
V
N
T
E
N
Q
I
A
S
A
K
A
V
R
D
V
L
N
N
D
K
E
V
Y
D
P
R
K
Y
L
G
P
A
R
E
A
I
K
E
T
V
K
G
K
I
K
E
F
G
T
S
N
R
A
K
H
-----------------------
37
PsiBlast_CBE
81.32
35%
-87
- C6 -
4TO8
2
?
B:
[2-285]
-
P
L
V
S
M
K
E
M
L
I
D
A
K
E
N
G
Y
A
V
G
Q
Y
N
I
N
N
L
E
F
T
Q
A
I
L
E
A
S
Q
E
E
N
A
P
V
I
L
G
V
S
E
G
A
-
A
R
Y
M
S
G
F
Y
---
T
I
V
K
M
V
E
--
G
L
M
-
H
D
L
NIT
I
P
V
A
I
H
L
D
H
G
S
S
F
E
K
C
K
E
A
I
D
A
G
F
T
S
V
M
I
D
A
S
-----
H
S
P
--
F
E
E
N
V
A
T
T
K
K
V
V
E
Y
A
H
E
K
G
V
S
V
E
A
E
L
G
T
V
G
-------
G
--
D
D
V
V
A
D
G
I
-----
I
Y
A
D
P
K
E
C
Q
E
L
V
E
K
T
G
I
D
A
L
A
P
A
L
G
S
V
H
-------
P
----
K
L
G
F
K
E
M
E
E
I
G
L
S
T
G
L
P
---
L
V
L
H
G
G
T
---------------------
G
I
P
T
K
D
I
Q
K
A
I
P
F
G
T
A
K
I
N
V
N
T
E
N
Q
I
A
S
A
K
A
V
R
D
V
L
N
N
D
K
E
V
Y
D
P
R
K
Y
L
G
P
A
R
E
A
I
K
E
T
V
K
G
K
I
K
E
F
G
T
S
N
R
A
K
H
-----------------------
12
PsiBlast_PDB
79.39
35%
-82
- C6 -
1GVF
11
KBAY_ECOLI
A:
[2-285]
-
S
I
I
S
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
G
T
-
F
K
H
I
A
L
E
E
I
-
Y
A
L
C
S
A
Y
S
--
T
T
Y
-
N
-----
M
P
L
A
L
H
L
D
H
H
E
S
L
D
D
I
R
R
K
V
H
A
G
V
R
S
A
M
I
D
G
S
-----
H
F
P
--
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
---------------------
S
A
F
L
T
D
P
Q
E
A
K
R
F
V
E
L
T
G
V
D
S
L
A
V
A
I
G
T
A
H
G
L
Y
--
S
K
T
P
K
I
D
---
F
Q
R
L
A
E
I
--
R
-
E
V
V
D
V
P
L
V
L
H
G
A
S
D
V
P
D
E
F
----------
V
R
R
T
-----------
I
E
L
G
V
T
K
V
N
V
A
T
E
L
K
I
A
F
A
G
A
V
K
A
W
F
A
E
N
P
Q
G
N
D
P
R
Y
Y
M
R
V
G
M
D
A
M
K
E
V
V
R
N
K
I
N
V
C
G
S
A
N
R
I
S
------------------------
38
PsiBlast_CBE
78.34
35%
-78
- C6 -
1GVF
12
KBAY_ECOLI
B:
[2-284]
-
S
I
I
S
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
G
T
-
F
K
H
I
A
L
E
E
I
-
Y
A
L
C
S
A
Y
S
--
T
T
Y
-
N
-----
M
P
L
A
L
H
L
D
H
H
E
S
L
D
D
I
R
R
K
V
H
A
G
V
R
S
A
M
I
D
G
S
-----
H
F
P
--
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
G
V
E
------------------
S
A
F
L
T
D
P
Q
E
A
K
R
F
V
E
L
T
G
V
D
S
L
A
V
A
I
G
T
A
H
G
L
Y
--
S
K
T
P
K
I
D
---
F
Q
R
L
A
E
I
--
R
-
E
V
V
D
V
P
L
V
L
H
G
A
S
D
V
P
D
E
F
----------
V
R
R
T
-----------
I
E
L
G
V
T
K
V
N
V
A
T
E
L
K
I
A
F
A
G
A
V
K
A
W
F
A
E
N
P
Q
G
N
D
P
R
Y
Y
M
R
V
G
M
D
A
M
K
E
V
V
R
N
K
I
N
V
C
G
S
A
N
R
I
-------------------------
13
PsiBlast_PDB
77.32
33%
-77
- C6 -
3Q94
10
?
A:
[6-288]
--
L
V
S
M
K
E
M
L
N
K
A
L
E
G
K
Y
A
V
G
Q
F
N
M
N
N
L
E
W
T
Q
A
I
L
A
A
A
E
E
E
K
S
P
V
I
L
G
V
S
E
G
A
A
R
H
M
T
G
F
K
T
V
V
A
M
V
K
A
L
I
E
--
E
M
N
I
T
-----
V
P
V
A
I
H
L
D
H
G
S
S
F
E
K
C
K
E
A
I
D
A
G
F
T
S
V
M
I
D
A
S
H
H
-------
P
F
E
E
N
V
E
T
T
K
K
V
V
E
Y
A
H
A
R
N
V
S
V
E
A
E
L
G
T
V
G
-------
G
Q
E
D
D
V
I
A
E
G
V
I
-----
Y
A
D
P
A
E
C
K
H
L
V
E
A
T
G
I
D
C
L
A
P
A
L
G
S
V
H
G
P
Y
K
--
G
E
P
N
L
G
F
A
E
M
E
Q
V
R
D
F
--
T
G
-
V
P
---
L
V
L
H
G
G
T
---------------------
G
I
P
T
A
D
I
E
K
A
I
S
L
G
T
S
K
I
N
V
N
T
E
N
Q
I
E
F
T
K
A
V
R
E
V
L
N
K
D
Q
E
V
Y
D
P
R
K
F
I
G
P
G
R
D
A
I
K
A
T
V
I
G
K
I
R
E
F
G
S
N
G
K
A
-------------------------