@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0576: (2016-01-10 )
MSGKAQQQSRLKELIARGREQGYLTYAEVNDHLPEDISDPEQVEDIIRMINDMGINVFETAPDADALLLAEADTDEAAAEEAAAALAAVESDIGRTTDPVRMYMREMGTVELLTREGEIEIAKRIEEGIREVMSAIAQFPGTVDSILADYNRIVAEGGRLSDVLSGYIDPDDGSLPAEEVEPVNLKDDSADSKEKDDEEEESDDSSDSDDEGDGGPDPEEARLRFTAVSEQLDKAKKALKKHGRGSKQATAELTGLAELFMPIKLVPKQFDALVARVRSALEGVRAQERAIMQLCVRDARMPRADFLRLFPNHETDEKWVDSVLKSKPKYAEAIERLRDDILRNQQKLAALESEVELTVAEIKEINRAMSIGEAKARRAKKEMVEANLRLVISIAKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRSIADQARTIRIPVHMIETINKLNRISRQMLQEMGREPTPEELGERMDMPEDKIRKVLKIAKEPISMETPIGDDEDSHLGDFIEDSTMQSPIEMATSESLKESTREVLAGLTAREAKVLRMRFGIDMNTDHTLEEVGKQFDVTRERIRQIEAKALRKLRHPSRSEHLRSFLDE
Atome Classification :
(32 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.--......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370--........380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490....--...500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.-......610.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSG
K
A
Q
Q
Q
S
R
L
K
E
L
I
ARGREQG
Y
L
T
Y
A
E
VNDHLPEDIS
D
P
E
Q
V
E
D
I
I
R
M
I
N
D
MG
I
N
V
F
ETAPDA
D
A
L
L
L
A
EADT
D
E
A
A
A
E
E
A
A
A
A
L
A
A
V
E
S
D
IGRT
T
D
P
V
R
M
Y
M
R
EMG
T
V
E
L
L
TREG
E
I
E
I
A
K
R
I
E
E
G
I
R
E
V
M
S
A
I
A
QFPG
T
V
D
S
I
L
A
D
Y
N
R
I
V
AEGG
R
L
S
D
V
L
S
GYIDPDDGSL
P
A
E
EVEPV--NLKDDSADSKEKDDEEEESDDSSDSDDEGDGGP
D
P
E
E
A
R
L
R
F
T
A
V
S
E
Q
L
D
K
A
K
K
A
L
K
KHGRGSK
Q
A
T
A
E
L
T
G
L
A
E
L
F
M
P
I
KLV
P
K
Q
F
D
A
L
V
A
R
V
R
S
A
L
E
G
V
R
A
Q
E
R
A
I
M
Q
L
C
V
RDARM
P
R
A
D
F
L
R
LFPNHE
T
D
E
K
W
V
D
S
V
L
KSKP
K
Y
A
E
A
I
E
R
L
R
D
D
I
L
R
N
Q
Q
K
L
A
A
L
E
S
E
V
E
L
T
V
A
E
I
K
E
I
N
R
A
MSI---
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
TNR
G
L
Q
F
L
D
L
I
Q
EGN
I
G
L
M
K
A
V
D
K
F
E
Y
RRGYKF
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
ADQA
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
MGREP
T
P
E
E
L
G
E
RMDM
P
E
D
--
K
I
R
K
V
L
K
I
A
KEPISMETPIGDDED
S
H
L
G
D
F
I
E
D
S
TMQS
P
I
E
M
A
T
S
E
S
L
K
E
S
T
R
E
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
FGIDMNTD
H
T
L
E
E
V
G
K
QF
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
LR-HP
S
R
S
E
H
L
R
S
F
LDE
77
Fugue
98.21
71%
-100
- C5 -
4LLG
-
RPOD_ECOLI
F:
[6-612]
-------
Q
S
Q
L
K
L
L
V
T
R
G
K
E
Q
G
Y
L
T
Y
A
E
V
N
D
H
L
P
E
D
I
V
D
S
D
Q
I
E
D
I
I
Q
M
I
N
D
M
G
I
Q
V
-----------------------------------
M
G
R
T
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
L
I
T
G
F
V
D
-------------------------------------------------
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
------
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
---
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
L
M
P
E
D
--
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
F
L
D
-
6
PsiBlast_PDB
96.72
66%
-100
- C5 -
4LLG
-
RPOD_ECOLI
F:
[6-612]
-------
Q
S
Q
L
K
L
L
V
T
R
G
K
E
Q
G
Y
L
T
Y
A
E
V
N
D
H
L
P
E
D
I
V
D
S
D
Q
I
E
D
I
I
Q
M
I
N
D
M
G
I
Q
V
M
-----------------------------------
G
R
T
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
L
I
T
G
F
V
D
-------------------------------------------------
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
------
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
---
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
L
M
P
E
D
--
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
F
L
D
-
11
PsiBlast_PDB
90.46
65%
-98
- C5 -
4LJZ
-
RPOD_ECOLI
F:
[1-521]
---------------------------------------------------------------------------------------------
G
R
T
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
L
I
T
G
F
V
D
-------------------------------------------------
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
------
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
---
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
L
M
P
E
D
--
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
F
L
D
-
14
PsiBlast_PDB
90.13
65%
-93
- C5 -
4XSY
-
?
F:
[1-521]
---------------------------------------------------------------------------------------------
G
R
T
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
L
I
T
G
F
V
D
-------------------------------------------------
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
------
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
---
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
L
M
P
E
D
--
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
F
L
D
-
7
PsiBlast_PDB
90.07
66%
-94
- C5 -
4YFK
-
RPOD_ECOLI
F:
[94-612]
-----------------------------------------------------------------------------------------------
T
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
L
I
T
G
F
V
D
-------------------------------------------------
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
------
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
---
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
L
M
P
E
D
--
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
F
L
D
-
12
PsiBlast_PDB
89.99
65%
-90
- C5 -
4LK0
-
RPOD_ECOLI
F:
[1-521]
---------------------------------------------------------------------------------------------
G
R
T
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
L
I
T
G
F
V
D
-------------------------------------------------
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
------
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
---
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
L
M
P
E
D
--
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
F
L
D
-
15
PsiBlast_PDB
89.88
65%
-96
- C5 -
4XSZ
-
?
F:
[1-521]
---------------------------------------------------------------------------------------------
G
R
T
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
L
I
T
G
F
V
D
-------------------------------------------------
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
------
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
---
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
L
M
P
E
D
--
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
F
L
D
-
13
PsiBlast_PDB
89.81
65%
-95
- C5 -
4XSX
-
?
F:
[1-521]
---------------------------------------------------------------------------------------------
G
R
T
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
L
I
T
G
F
V
D
-------------------------------------------------
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
------
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
---
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
L
M
P
E
D
--
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
F
L
D
-
10
PsiBlast_PDB
89.57
66%
-94
- C5 -
4YG2
-
RPOA_ECOLI (first)
F:
[94-612]
-----------------------------------------------------------------------------------------------
T
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
L
I
T
G
F
V
D
-------------------------------------------------
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
------
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
---
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
L
M
P
E
D
--
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
F
L
D
-
8
PsiBlast_PDB
89.42
66%
-96
- C5 -
4YFN
-
RPOD_ECOLI
F:
[94-612]
-----------------------------------------------------------------------------------------------
T
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
L
I
T
G
F
V
D
-------------------------------------------------
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
------
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
---
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
L
M
P
E
D
--
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
F
L
D
-
21
PsiBlast_CBE
88.44
66%
-96
- C5 -
4KN4
1
RPOD_ECOLI
Y:
[95-609]
------------------------------------------------------------------------------------------------
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
-------------------------------------------------------------
I
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
K
G
R
S
H
A
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
---
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
L
M
P
E
D
--
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
----
22
PsiBlast_CBE
88.23
66%
-95
- C5 -
4KMU
1
RPOD_ECOLI
Y:
[95-609]
------------------------------------------------------------------------------------------------
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
-------------------------------------------------------------
I
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
K
G
R
S
H
A
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
---
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
L
M
P
E
D
--
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
----
9
PsiBlast_PDB
84.91
66%
-82
- C5 -
4YFX
-
RPOD_ECOLI
F:
[95-609]
------------------------------------------------------------------------------------------------
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
-------------------------------------------------------------
I
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
K
G
R
S
H
A
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
---
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
L
M
P
E
D
--
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
----
16
PsiBlast_PDB
65.68
52%
-79
* C10 *
1SIG
-
RPOD_ECOLI
A:
[114-446]
-------------------------------------------------------------------------------------------------------------------
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
N
R
V
E
A
E
E
A
R
L
S
D
L
I
T
G
F
V
D
---------
D
L
A
P
T
AT
H
V
G
S
E
L
S
Q
E
D
L
D
--------------------
I
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
----
H
A
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
---
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
65.13
51%
-71
- C10 -
1SIG
-
RPOD_ECOLI
A:
[113-446]
------------------------------------------------------------------------------------------------------------------
M
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
N
R
V
E
A
E
E
A
R
L
S
D
L
I
T
--
G
F
V
D
-----
D
L
A
P
T
A
T
--
H
V
G
S
E
L
S
Q
E
D
L
D
--------------------
I
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
----
H
A
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
---
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
63.60
61%
-69
- C5 -
4OIN
3
?
F:
[188-443]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
H
K
R
Y
L
H
I
A
R
E
G
E
A
----
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
D
-
24
PsiBlast_CBE
63.33
61%
-67
- C5 -
4Q4Z
2
?
F:
[168-423]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
H
K
R
Y
L
H
I
A
R
E
G
E
A
----
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
D
-
33
PsiBlast_CBE
62.88
61%
-70
- C5 -
4OIO
2
?
F:
[188-441]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
H
K
R
Y
L
H
I
A
R
E
G
E
A
----
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
---
36
PsiBlast_CBE
62.61
61%
-69
- C5 -
4G7Z
2
?
F:
[188-443]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
H
K
R
Y
L
H
I
A
R
E
G
E
A
----
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
D
-
31
PsiBlast_CBE
62.52
61%
-67
- C5 -
4OIQ
3
?
F:
[188-443]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
H
K
R
Y
L
H
I
A
R
E
G
E
A
----
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
D
-
30
PsiBlast_CBE
62.41
61%
-68
- C5 -
4OIR
4
?
F:
[188-443]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
H
K
R
Y
L
H
I
A
R
E
G
E
A
----
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
D
-
32
PsiBlast_CBE
62.39
61%
-68
- C5 -
4OIP
3
?
F:
[188-443]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
H
K
R
Y
L
H
I
A
R
E
G
E
A
----
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
D
-
38
PsiBlast_CBE
62.38
61%
-67
- C5 -
4G7O
2
?
F:
[188-443]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
H
K
R
Y
L
H
I
A
R
E
G
E
A
----
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
D
-
40
PsiBlast_CBE
62.17
61%
-68
- C5 -
4G7H
3
?
F:
[188-443]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
H
K
R
Y
L
H
I
A
R
E
G
E
A
----
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
D
-
39
PsiBlast_CBE
61.98
61%
-64
- C5 -
4G7H
4
?
P:
[188-443]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
H
K
R
Y
L
H
I
ARE
G
E
A
----
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
G
W
D
AK
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
D
-
37
PsiBlast_CBE
61.96
61%
-67
- C5 -
4G7O
2
?
P:
[188-443]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
H
K
R
Y
L
H
I
ARE
G
E
A
----
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
G
W
D
AK
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
D
-
23
PsiBlast_CBE
61.46
61%
-66
- C5 -
4Q5S
1
?
F:
[168-422]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
H
K
R
Y
L
H
I
A
R
E
G
E
A
----
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
-------
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
--
35
PsiBlast_CBE
61.14
61%
-66
- C5 -
4G7Z
2
?
P:
[188-443]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
H
K
R
Y
L
H
I
ARE
G
E
A
----
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
G
W
D
AK
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
D
-
43
PsiBlast_CBE
47.97
64%
-55
- C5 -
4KI2
1
SIGA_THEAQ
B:
[96-239]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
K
R
Y
L
H
I
ARE
G
E
A
----
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
G
P
G
W
D
AK
R
V
E
E
T
L
K
I
A
-----------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
44.99
64%
-48
- C5 -
3UGP
1
SIGA_THEAQ
A:
[96-184]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
K
R
Y
L
H
I
A
R
E
G
E
A
----
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
44.84
64%
-49
- C5 -
3UGO
1
SIGA_THEAQ
A:
[96-184]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
K
R
Y
L
H
I
A
R
E
G
E
A
----
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
43.27
64%
-50
- C5 -
4KI2
1
SIGA_THEAQ
A:
[96-183]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
K
R
Y
L
H
I
A
R
E
G
E
A
----
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------