@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0580: (2016-01-10 )
MRVLGLETSCDETGVALYDSERGLLADALFSQIDLHRVYGGVVPELASRDHVKRMLPLIRQVLDESGCTPADIDAIAYTAGPGLVGALLVGASCAQAMAFAWGVPAVGVHHMEGHLLAPMLEEQPPRFPFVALLVSGGHTQLVRVDGIGRYQLLGESVDDAAGEAFDKTAKLIGLGYPGGPEIARLAERGTPGRFVFPRPMTDRPGLDFSFSGLKTFTLNTWQRCVEAGDDSEQTRCDIALAFQTAVVETLLIKCRRALKQTGLKNLVIAGGVSANQALRSGLEKMLGEMKGQVFYARPRFCTDNGAMIAYAGCQRLLAGQHDGPAISVQPRWPMESLPAV
Atome Classification :
(22 SA)
.........10........20......--..30...--...-..40........50........60........70........80........90........100.......110....-...120-....--....130.......140.-......150.......160.......170.......180.......190.---------...-...200.-......210.......220...--....230.....-..240.......250.......260----........270.......280.......290...----....300........310...-----....320--.-.....-..330.......340-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
R
V
LGLETSCDET
G
V
A
L
YDSER
G
L
L
A
D
--
A
L
F
S
Q
I
D
--
L
H
R
-
V
YGGV
V
P
E
L
A
S
R
D
H
V
K
R
M
L
P
L
I
R
Q
V
L
DESGCTPADI
D
A
I
A
YTAG
P
G
L
V
G
A
L
L
V
G
A
S
C
A
Q
A
M
A
F
AWGVPAV
G
V
HHMEGH
L
-
L
A
P
M
L
--EEQP--PRF
P
F
V
A
L
L
VSGG
H
T
Q
L
V
-
R
VDGIG
R
Y
Q
L
LGESV
D
D
A
A
G
E
A
F
D
K
T
A
K
L
I
G
LGYPG
G
P
E
I
A
R
L
A
ERGTPG---------
R
F
V
-FPRPMTD-RPGL
D
F
SFSG
L
K
T
F
T
L
N
T
W
Q
R
C
--
V
EAGDDSEQ
T
R
C
-
D
I
A
L
A
F
Q
T
A
V
V
E
T
L
L
I
K
C
R
R
A
L
K
Q-----TGLK
N
L
V
I
AGGV
S
A
N
Q
A
L
R
S
G
L
E
K
M
L
G
EMKG
Q
V
F
----YARPR-FCTDNG
A
M
I
A
Y
A
G
C
Q
-----
R
L
L
AG-Q--H-DG
P
A
I
-
S
V
QPRWPMESLPAV--
1
PsiBlast_PDB
96.01
69%
-117
- C2 -
4YDU
7
TSAD_ECOLI
A:
[1-336]
M
R
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
E
K
G
L
L
A
N
--
Q
L
Y
S
Q
V
K
--
L
H
A
-
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
-
L
A
P
M
L
--
E
D
N
P
--
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
M
A
A
Q
G
T
A
G
---------
R
F
V
-
F
P
R
P
M
T
D
-
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
-----
D
N
G
T
D
-
D
Q
T
R
A
-
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
D
Q
-----
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
E
V
F
----
Y
A
R
P
E
-
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
-----
R
F
K
A
G
-
A
--
T
-
A
D
L
G
V
-
S
V
R
P
R
W
P
L
A
E
L
P
A
---
21
PsiBlast_CBE
95.85
69%
-118
- C2 -
4YDU
7
TSAD_ECOLI
B:
[1-336]
M
R
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
E
K
G
L
L
A
N
--
Q
L
Y
S
Q
V
K
--
L
H
A
-
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
-
L
A
P
M
L
--
E
D
N
P
--
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
M
A
A
Q
G
T
A
G
---------
R
F
V
-
F
P
R
P
M
T
D
-
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
-----
D
N
G
T
D
-
D
Q
T
R
A
-
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
D
Q
-----
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
E
V
F
----
Y
A
R
P
E
-
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
-----
R
F
K
A
G
-
A
--
T
-
A
D
L
G
V
-
S
V
R
P
R
W
P
L
A
E
L
P
A
A
--
4
PsiBlast_PDB
95.82
69%
-119
- C2 -
4WQ4
3
TSAD_ECOLI
A:
[1-336]
M
R
V
L
G
I
E
T
S
C
D
A
T
G
I
A
I
Y
D
D
E
K
G
L
L
A
N
--
Q
L
Y
S
Q
V
K
--
L
H
A
-
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
-
L
A
P
M
L
--
E
D
N
P
--
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
M
A
A
Q
G
T
A
G
---------
R
F
V
-
F
P
R
P
M
T
D
-
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
-----
D
N
G
T
D
-
D
Q
T
R
A
-
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
D
Q
-----
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
E
V
F
----
Y
A
R
P
E
-
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
-----
R
F
K
A
G
-
A
--
T
-
A
D
L
G
V
-
S
V
R
P
R
W
P
L
A
E
L
P
A
---
22
PsiBlast_CBE
95.51
68%
-119
- C2 -
3ZEU
4
?
E:
[1-336]
M
R
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
K
K
G
L
L
A
N
--
Q
L
Y
S
Q
V
K
--
L
H
A
-
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
A
G
L
T
A
S
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
N
V
P
A
I
P
V
H
H
M
E
G
H
L
-
L
A
P
M
L
--
E
D
N
P
--
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
M
L
S
K
M
A
S
Q
G
T
A
G
---------
R
F
V
-
F
P
R
P
M
T
D
-
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
------
I
R
S
N
G
G
D
E
Q
T
R
A
-
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
E
S
-----
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
Q
K
R
R
G
E
V
F
----
Y
A
R
P
E
-
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
-----
R
F
K
A
G
-
V
--
T
-
A
D
L
G
V
-
T
V
R
P
R
W
P
L
A
E
L
P
A
A
--
3
PsiBlast_PDB
95.42
68%
-117
- C2 -
3ZEU
5
?
B:
[1-336]
M
R
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
K
K
G
L
L
A
N
--
Q
L
Y
S
Q
V
K
--
L
H
A
-
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
A
G
L
T
A
S
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
N
V
P
A
I
P
V
H
H
M
E
G
H
L
-
L
A
P
M
L
--
E
D
N
P
--
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
M
L
S
K
M
A
S
Q
G
T
A
G
---------
R
F
V
-
F
P
R
P
M
T
D
-
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
------
I
R
S
N
G
G
D
E
Q
T
R
A
-
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
E
S
-----
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
Q
K
R
R
G
E
V
F
----
Y
A
R
P
E
-
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
-----
R
F
K
A
G
-
V
--
T
-
A
D
L
G
V
-
T
V
R
P
R
W
P
L
A
E
L
P
A
A
--
5
PsiBlast_PDB
95.41
69%
-116
- C2 -
4WQ5
5
TSAD_ECOLI
A:
[1-332]
M
R
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
E
K
G
L
L
A
N
--
Q
L
Y
S
Q
V
K
--
L
H
A
-
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
E
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
-
L
A
P
M
L
--
E
D
N
P
--
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
M
A
A
Q
G
T
A
G
---------
R
F
V
-
F
P
R
P
M
T
D
-
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
-----
D
N
G
T
D
-
D
Q
T
R
A
-
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
D
Q
-----
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
E
V
F
----
Y
A
R
P
E
-
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
-----
R
F
K
A
G
-
A
--
T
-
A
D
L
G
V
-
S
V
R
P
R
W
P
L
A
-------
24
PsiBlast_CBE
94.99
69%
-114
- C2 -
4WQ5
4
TSAD_ECOLI
B:
[1-336]
M
R
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
E
K
G
L
L
A
N
--
Q
L
Y
S
Q
V
K
--
L
H
A
-
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
E
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
-
L
A
P
M
L
--
E
D
N
P
--
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
M
A
A
Q
G
T
A
G
---------
R
F
V
-
F
P
R
P
M
T
D
-
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
-----
D
N
G
T
D
-
D
Q
T
R
A
-
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
D
Q
-----
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
E
V
F
----
Y
A
R
P
E
-
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
-----
R
F
K
A
G
-
A
--
T
-
A
D
L
G
V
-
S
V
R
P
R
W
P
L
A
E
L
P
A
---
2
PsiBlast_PDB
94.95
68%
-117
- C2 -
3ZET
2
?
B:
[1-336]
M
R
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
K
K
G
L
L
A
N
--
Q
L
Y
S
Q
V
K
--
L
H
A
-
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
A
G
L
T
A
S
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
N
V
P
A
I
P
V
H
H
M
E
G
H
L
-
L
A
P
M
L
--
E
D
N
P
--
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
M
L
S
K
M
A
S
Q
G
T
A
G
---------
R
F
V
-
F
P
R
P
M
T
D
-
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
------
I
R
S
N
G
G
D
E
Q
T
R
A
-
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
E
S
-----
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
Q
K
R
R
G
E
V
F
----
Y
A
R
P
E
-
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
-----
R
F
K
A
G
-
V
--
T
-
A
D
L
G
V
-
T
V
R
P
R
W
P
L
A
E
L
P
A
A
--
23
PsiBlast_CBE
94.05
69%
-116
- C2 -
4WQ4
4
TSAD_ECOLI
B:
[1-336]
M
R
V
L
G
I
E
T
S
C
D
A
T
G
I
A
I
Y
D
D
E
K
G
L
L
A
N
--
Q
L
Y
S
Q
V
K
--
L
H
A
-
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
-
L
A
P
M
L
--
E
D
N
P
--
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
M
A
A
Q
G
T
A
G
---------
R
F
V
-
F
P
R
P
M
T
D
-
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
-----
D
N
G
T
D
-
D
Q
T
R
A
-
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
D
Q
-----
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
E
V
F
----
Y
A
R
P
E
-
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
-----
R
F
K
A
G
-
A
--
T
-
A
D
L
G
V
-
S
V
R
P
R
W
P
L
A
E
L
P
A
---
32
HHSearch
93.44
66%
-116
- C2 -
3ZEU
5
?
B:
[1-336]
M
R
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
K
K
G
L
L
A
N
--
Q
L
Y
S
Q
V
K
--
L
H
A
-
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
A
G
L
T
A
S
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
N
V
P
A
I
P
V
H
H
M
E
G
H
L
-
L
A
P
M
L
--
E
D
N
P
PE
F
-
P
F
V
A
L
L
V
S
G
G
H
T
Q
-
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
M
L
S
K
M
A
S
Q
G
T
A
G
---------
R
F
V
-
F
P
R
P
M
T
D
-
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
S
N
------
G
G
D
E
Q
T
R
A
-
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
E
S
-----
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
Q
K
R
R
G
E
V
F
----
Y
A
R
P
E
-
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
-----
R
F
K
A
G
-
V
--
T
-
A
D
L
G
V
-
T
V
R
P
R
W
P
L
A
E
L
P
A
A
--
53
Fugue
73.78
35%
-98
- C2 -
2IVN
3
KAE1_PYRAB
A:
[1-325]
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
S
-
E
D
K
V
L
A
N
--
V
F
D
T
L
-----
T
T
-
E
K
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
-
E
I
T
K
M
--
F
G
V
K
--
D
---
P
V
G
L
Y
V
S
G
G
N
T
Q
V
L
-
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
L
A
E
K
G
E
K
----------
Y
I
E
-
L
P
Y
A
V
K
----
G
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
S
---------
G
K
Y
R
V
E
-
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
-----
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
R
I
M
T
E
D
R
G
I
K
F
F
----
V
P
P
Y
D
-
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
-----
M
Y
K
A
G
-
I
--
S
-
F
R
L
E
E
T
I
V
K
Q
K
F
R
T
D
E
V
E
I
V
WH
34
HHSearch
73.14
34%
-99
- C2 -
2IVN
3
KAE1_PYRAB
A:
[1-323]
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
S
E
-
D
K
V
L
A
N
V
F
D
T
L
T
T
E
K
--------
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
-
E
I
T
K
M
--
F
G
V
---
K
-
D
P
V
G
L
Y
V
S
-
G
G
N
T
Q
V
L
-
A
L
-
E
G
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
L
A
E
K
G
E
K
Y
----------
I
E
-
L
P
Y
A
V
----
K
G
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
S
---------
G
K
Y
R
V
E
-
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
-----
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
R
I
M
T
E
D
R
G
I
K
F
F
----
V
P
P
Y
D
-
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
-----
M
Y
K
A
G
-
I
--
S
-
F
R
L
E
E
T
I
V
K
Q
K
F
R
T
D
E
V
E
I
V
--
7
PsiBlast_PDB
71.72
37%
-108
- C2 -
2IVO
3
KAE1_PYRAB
A:
[1-301]
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
D
K
V
L
A
N
---
V
F
D
T
L
T
--
T
E
K
---
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
F
--
G
V
K
D
--
P
----
V
G
L
Y
V
S
G
G
N
T
Q
V
L
-
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
L
A
E
K
G
E
-----------
K
Y
I
E
L
P
Y
A
V
----
K
G
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
----------
S
G
K
Y
R
V
E
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
-----
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
-
R
I
M
T
E
D
R
G
I
K
F
----
F
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
-----
M
Y
K
A
G
-
I
--
S
-
F
R
L
E
E
-
T
I
V
K
Q
K
F
R
T
D
E
V
E
I
--
26
PsiBlast_CBE
71.41
37%
-109
- C2 -
2IVO
3
KAE1_PYRAB
C:
[1-301]
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
D
K
V
L
A
N
---
V
F
D
T
L
T
--
T
E
K
---
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
F
--
G
V
K
D
--
P
----
V
G
L
Y
V
S
G
G
N
T
Q
V
L
-
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
L
A
E
K
G
E
-----------
K
Y
I
E
L
P
Y
A
V
----
K
G
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
----------
S
G
K
Y
R
V
E
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
-----
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
-
R
I
M
T
E
D
R
G
I
K
F
----
F
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
-----
M
Y
K
A
G
-
I
--
S
-
F
R
L
E
E
-
T
I
V
K
Q
K
F
R
T
D
E
V
E
I
--
8
PsiBlast_PDB
71.35
37%
-105
- C2 -
2IVP
2
KAE1_PYRAB
A:
[1-301]
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
D
K
V
L
A
N
---
V
F
D
T
L
T
--
T
E
K
---
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
F
--
G
V
K
D
--
P
----
V
G
L
Y
V
S
G
G
N
T
Q
V
L
-
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
L
A
E
K
G
E
-----------
K
Y
I
E
L
P
Y
A
V
----
K
G
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
----------
S
G
K
Y
R
V
E
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
-----
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
-
R
I
M
T
E
D
R
G
I
K
F
----
F
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
-----
M
Y
K
A
G
-
I
--
S
-
F
R
L
E
E
-
T
I
V
K
Q
K
F
R
T
D
E
V
E
I
--
6
PsiBlast_PDB
71.13
37%
-106
- C2 -
2IVN
3
KAE1_PYRAB
A:
[1-301]
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
D
K
V
L
A
N
---
V
F
D
T
L
T
--
T
E
K
---
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
F
--
G
V
K
D
--
P
----
V
G
L
Y
V
S
G
G
N
T
Q
V
L
-
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
L
A
E
K
G
E
-----------
K
Y
I
E
L
P
Y
A
V
----
K
G
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
----------
S
G
K
Y
R
V
E
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
-----
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
-
R
I
M
T
E
D
R
G
I
K
F
----
F
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
-----
M
Y
K
A
G
-
I
--
S
-
F
R
L
E
E
-
T
I
V
K
Q
K
F
R
T
D
E
V
E
I
--
27
PsiBlast_CBE
71.04
37%
-108
- C2 -
2IVO
2
KAE1_PYRAB
B:
[1-301]
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
D
K
V
L
A
N
---
V
F
D
T
L
T
--
T
E
K
---
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
F
--
G
V
K
D
--
P
----
V
G
L
Y
V
S
G
G
N
T
Q
V
L
-
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
L
A
E
K
G
E
-----------
K
Y
I
E
L
P
Y
A
V
----
K
G
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
----------
S
G
K
Y
R
V
E
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
-----
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
-
R
I
M
T
E
D
R
G
I
K
F
----
F
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
-----
M
Y
K
A
G
-
I
--
S
-
F
R
L
E
E
-
T
I
V
K
Q
K
F
R
T
D
E
V
E
I
--
25
PsiBlast_CBE
70.77
37%
-110
- C2 -
2IVO
2
KAE1_PYRAB
D:
[1-301]
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
D
K
V
L
A
N
---
V
F
D
T
L
T
--
T
E
K
---
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
F
--
G
V
K
D
--
P
----
V
G
L
Y
V
S
G
G
N
T
Q
V
L
-
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
L
A
E
K
G
E
-----------
K
Y
I
E
L
P
Y
A
V
----
K
G
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
----------
S
G
K
Y
R
V
E
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
-----
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
-
R
I
M
T
E
D
R
G
I
K
F
----
F
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
-----
M
Y
K
A
G
-
I
--
S
-
F
R
L
E
E
-
T
I
V
K
Q
K
F
R
T
D
E
V
E
I
--
10
PsiBlast_PDB
70.25
30%
-99
- C2 -
3ENO
1
KAE1B_THEAC
A:
[6-327]
M
I
V
L
G
L
E
G
T
A
H
T
I
S
C
G
I
I
D
E
S
R
I
L
A
M
E
--
S
-----
S
--
M
Y
R
P
K
T
G
G
I
R
P
L
D
A
A
V
H
H
S
E
V
I
D
T
V
I
S
R
A
L
E
K
A
K
I
S
I
H
D
I
D
L
I
G
F
S
M
G
P
G
L
A
P
S
L
R
V
T
A
T
A
A
R
T
I
S
V
L
T
G
K
P
I
I
G
V
N
H
P
L
G
H
I
---
E
I
G
--
R
R
V
T
--
G
A
I
D
P
V
M
L
Y
V
S
G
G
N
T
Q
V
I
A
H
V
N
G
--
R
Y
R
V
L
G
E
T
L
D
I
G
I
G
N
M
I
D
K
F
A
R
E
A
G
I
P
F
P
G
G
P
E
I
E
K
L
A
M
K
G
T
K
------------
L
-
L
D
L
P
Y
S
V
-
K
-
G
M
D
T
A
F
S
G
I
L
T
A
A
L
Q
Y
L
K
----------
T
G
Q
A
I
E
-
D
I
S
Y
S
I
Q
E
T
A
F
A
M
L
V
E
V
L
E
R
A
L
Y
V
-----
S
G
K
D
E
I
L
M
A
G
G
V
A
L
N
R
R
L
R
D
M
V
T
N
M
A
R
E
A
G
I
R
S
Y
----
L
T
D
R
E
-
Y
C
M
D
N
G
I
M
I
A
Q
A
A
L
L
-----
M
Y
K
S
G
V
R
--
M
-
S
V
E
E
T
-
A
V
N
P
R
F
R
I
D
E
V
D
A
P
--
33
HHSearch
69.31
27%
-107
* C2 *
3EN9
1
KAE1B_METJA
A:
[6-324]
M
I
C
L
G
L
E
G
T
A
E
K
T
G
V
G
I
V
T
S
D
G
E
V
L
F
N
K
T
I
M
Y
K
P
P
K
--------
Q
G
I
N
P
R
E
A
A
D
H
H
A
E
T
F
P
K
L
I
K
E
A
F
E
V
--
V
D
K
N
E
I
D
L
I
A
F
S
Q
G
P
G
L
G
P
S
L
R
V
T
A
T
V
A
R
T
L
S
L
T
L
K
K
P
I
I
G
V
N
H
C
I
A
H
I
-
E
I
G
K
L
--
T
T
E
---
A
-
E
D
P
L
T
L
Y
V
S
G
G
N
T
Q
V
I
-
A
Y
-
V
S
K
K
Y
R
V
F
G
E
T
L
D
I
A
V
G
N
C
L
D
Q
F
A
R
Y
V
N
L
P
H
P
G
G
P
Y
I
E
E
L
A
R
K
G
K
K
L
----------
V
D
-
L
P
Y
T
V
----
K
G
M
D
I
A
F
S
G
L
L
T
A
A
M
R
A
Y
D
----------
A
G
E
R
L
E
-
D
I
C
Y
S
L
Q
E
Y
A
F
S
M
L
T
E
I
T
E
R
A
L
A
H
-----
T
N
K
G
E
V
M
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
K
A
M
C
E
G
Q
N
V
D
F
Y
----
V
P
P
K
---
E
F
C
G
D
N
G
A
M
I
A
W
L
G
-----
L
L
M
H
K
-
N
G
R
W
M
S
L
D
E
T
-
K
I
I
P
N
Y
R
T
D
M
V
E
V
N
--
9
PsiBlast_PDB
69.27
32%
-109
- C2 -
3WUH
2
QRI7_YEAST
A:
[10-375]
-
K
V
L
A
I
E
T
S
C
D
D
T
C
V
S
V
L
D
R
F
S
K
S
A
A
P
--
N
V
L
A
N
L
K
D
T
L
D
----------
K
A
H
I
H
H
Q
A
R
I
G
P
L
T
E
R
A
L
I
E
S
N
A
R
E
G
-
I
D
L
I
C
V
T
R
G
P
G
M
P
G
S
L
S
G
G
L
D
F
A
K
G
L
A
V
A
W
N
K
P
L
I
G
V
H
H
M
L
G
H
L
-
L
I
P
R
M
GT
N
G
K
V
--
P
Q
F
P
F
V
S
L
L
V
S
G
G
H
T
T
F
V
-
L
S
R
A
I
D
D
H
E
I
L
C
D
T
I
D
I
A
V
G
D
S
L
D
K
C
G
R
E
L
G
F
---
K
G
T
M
I
A
R
E
M
E
K
F
I
N
Q
D
INDQDFAL
K
L
E
-
M
P
------
R
N
M
L
S
F
S
F
S
A
F
I
T
A
L
R
T
N
L
T
K
L
GK
T
-----
P
E
R
E
I
R
-
S
I
A
Y
Q
V
Q
E
S
V
F
D
H
I
I
N
K
L
K
H
V
L
K
S
Q
PEKF
K
N
V
R
E
F
V
C
S
G
G
V
S
S
N
Q
R
L
R
T
K
L
E
T
E
L
--------F
N
F
Y
Y
P
P
M
D
-
L
C
S
D
N
S
I
M
I
G
W
A
G
I
E
I
W
E
SL
R
L
V
S
D
-
L
--
D
-
I
C
P
I
-----
R
Q
W
P
L
N
D
L
L
S
V
--
28
PsiBlast_CBE
68.69
32%
-105
- C2 -
3WUH
2
QRI7_YEAST
B:
[10-375]
-
K
V
L
A
I
E
T
S
C
D
D
T
C
V
S
V
L
D
R
F
S
K
S
A
A
P
--
N
V
L
A
N
L
K
DT
L
-----------
K
A
H
I
H
H
Q
A
R
I
G
P
L
T
E
R
A
L
I
E
S
N
A
R
E
G
-
I
D
L
I
C
V
T
R
G
P
G
M
P
G
S
L
S
G
G
L
D
F
A
K
G
L
A
V
A
W
N
K
P
L
I
G
V
H
H
M
L
G
H
L
-
L
I
P
R
M
GT
N
G
K
V
--
P
Q
F
P
F
V
S
L
L
V
S
G
G
H
T
T
F
V
-
L
S
R
A
I
D
D
H
E
I
L
C
D
T
I
D
I
A
V
G
D
S
L
D
K
C
G
R
E
L
G
F
---
K
G
T
M
I
A
R
E
M
E
K
F
I
N
Q
DINDQDFA
L
K
L
E
-
M
P
S
----K
R
N
M
L
S
F
S
F
S
A
F
I
T
A
L
R
T
N
L
T
K
L
GK
T
E
I
Q
E
L
P
E
R
E
I
R
-
S
I
A
Y
Q
V
Q
E
S
V
F
D
H
I
I
N
K
L
K
H
V
L
K
S
QPEKF
K
N
V
R
E
F
V
C
S
G
G
V
S
S
N
Q
R
L
R
T
K
L
E
T
E
L
--------F
N
F
Y
Y
P
P
M
D
-
L
C
S
D
N
S
I
M
I
G
W
A
G
I
E
I
W
E
SL
R
L
V
S
D
-
L
--
D
-
I
C
P
I
-----
R
Q
W
P
L
N
D
L
L
S
V
--