@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0603: (2016-01-11 )
MAETQGGDVLVSFRGVQKSYDGETLIVKDLNLDIRKGEFLTLLGPSGSGKTTSLMMLAGFETPTAGEILLAGRSINNVPPHKRDIGMVFQNYALFPHMTVAENLAFPLSVRGMSKTDVKERVKRALSMVQLDAFAGRYPAQLSGGQQQRVALARALVFEPQLVLMDEPLGALDKQLREHMQMEIKHLHQRLGVTVVYVTHDQGEALTMSDRVAVFHQGEIQQIEPPRNLYEQPRNTFVANFIGENNRLSGQLLSCDGERCVVGLPRGEKVEALAVNVGQPGEPVTLSIRPERVRLNGASESCVNRFSGRVAEFVYLGDHVRVRLEVCGRDDFFVKQPIAELDPTLSVGDVVPLGWQVEHVRALDPLPAA
Atome Classification :
(39 SA)
.........10........20.-.-....--...30........40........50........60........70....----..-----..80-----...-.....90........100....-...110.......120.......130---........140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.--.--.--....250.......260-...-....------270..----.---....280.......290...---..---..300-.---........310.......320.......-330.......340.......350.......360.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAETQGG
D
V
L
V
S
F
RGVQKSY-D-G-
E
T
L
I
--
V
K
DLN
L
D
IRKG
E
F
L
T
L
LGPSGSG
K
T
T
S
L
M
M
L
AGFETPTAG
E
I
L
L
AGRSI----NN-----VPP
H
-----
K
R
D
-
I
G
M
V
F
Q
NYALFP
H
M
T
V
A
E
NLAF-
P
L
S
VRGM
S
K
T
D
V
K
E
R
V
K
R
A
L
S
M
V
Q
L
----
D
A
FAGRY
P
A
QLSGG
Q
Q
Q
R
V
A
L
A
R
A
L
VFEP
Q
L
V
L
MDEP
L
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A
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H
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RL
G
V
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V
Y
V
THDQG
E
A
LTMS
D
R
V
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F
HQGEIQQIEP
P
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N
L
Y
EQP
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A
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IG--E--N--NRLS
G
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E
K
------
V
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----
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P
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VCGR-DDFFVKQ
P
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A
ELDPTLSVGDVVPLG
W
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H
V
RALDPLPAA
121
HHSearch
86.16
41%
-101
- C1 -
2YYZ
3
?
A:
[2-355]
--------
P
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110
Fugue
84.34
38%
-100
- C1 -
1Z47
1
?
A:
[11-355]
------
G
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----
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------
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----
123
HHSearch
83.85
39%
-94
- C1 -
1Z47
1
?
A:
[11-354]
------
G
S
M
T
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F
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-----
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--------
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----
119
HHSearch
83.67
42%
-99
- C1 -
1V43
-
?
A:
[8-369]
-----
I
K
M
V
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K
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N
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----
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-----
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------
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M
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P
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----
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------
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L
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111
Fugue
82.74
34%
-94
- C1 -
1OXS
23
?
C:
[1-352]
M
V
R
-------
I
I
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V
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G
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----
126
HHSearch
80.25
34%
-92
- C1 -
1OXX
25
?
K:
[1-352]
-------
M
V
R
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Q
V
A
S
L
I
G
--
E
--
I
--
N
E
L
E
G
K
V
T
N
E
G
V
V
I
--------
G
S
L
R
------
F
P
------------
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
---
S
K
---
D
V
I
KDD
S
---
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
--
E
E
E
I
F
---
T
Y
S
D
H
P
I
H
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
----
120
HHSearch
80.15
37%
-96
- C1 -
2IT1
-
?
A:
[1-354]
-------
M
V
E
I
K
L
E
N
I
V
K
K
F
-
G
-
N
--
F
T
A
--
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
K
D
V
----
T
E
-----
L
P
P
K
-----
D
R
N
-
V
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
-
P
L
E
L
R
K
A
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
----
D
K
L
L
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
G
--
N
--
P
P
M
N
F
V
E
A
K
V
E
D
G
K
L
V
I
T
-------
E
K
S
K
------
L
P
I
P
K
QY
V
E
I
---
V
K
E
T
G
I
T
E
V
I
I
G
F
R
P
H
D
A
E
I
---
V
K
---
G
E
---------
G
E
G
I
V
G
E
V
Y
S
F
E
P
L
G
R
E
Q
I
V
T
V
S
V
N
D
S
--
I
V
K
V
F
A
P
-
E
--
G
E
H
F
S
F
G
E
K
V
T
I
K
V
K
E
E
L
L
V
L
F
D
K
K
T
E
K
124
HHSearch
79.48
36%
-98
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-359]
--------
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
-
E
--
V
V
V
--
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
-----
T
P
P
A
-----
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
----
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
K
M
--
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
------
V
W
L
P
V
E---
S
---
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
---
S
D
---
I
A
---------
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
---
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
42
PsiBlast_CBE
79.05
36%
-113
- C1 -
1OXU
14
?
C:
[2-315]
--------
V
R
I
I
V
K
N
V
S
K
V
F
-
K
K
G
-
K
V
V
A
--
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
----
A
S
NGKLI
V
P
P
E
-----
D
R
K
-
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
-
P
L
T
N
M
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
----
H
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
--
E
--
I
--
N
E
L
E
G
K
V
T
N
---
E
G
V
V
I
-
G
---------------
S
L
R
----
F
---
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
---
S
K
DVI
K
D
D
---
S
---
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
-
E
E
E
I
F
T
Y
S
D
H
P
I
H
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
N
-------
39
PsiBlast_CBE
79.01
36%
-115
- C1 -
1OXV
15
?
D:
[2-315]
--------
V
R
I
I
V
K
N
V
S
K
V
F
-
K
K
G
-
K
V
V
A
--
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
----
A
S
NGKLI
V
P
P
E
-----
D
R
K
-
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
-
P
L
T
N
M
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
----
H
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
--
E
--
I
--
N
E
L
E
G
K
V
T
N
---
E
G
V
V
I
-
G
---------------
S
L
R
----
F
---
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
---
S
K
DVI
K
D
D
---
S
---
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
-
E
E
E
I
F
T
Y
S
D
H
P
I
H
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
N
-------
46
PsiBlast_CBE
78.87
36%
-111
- C1 -
1OXX
25
?
K:
[2-315]
--------
V
R
I
I
V
K
N
V
S
K
V
F
-
K
K
G
-
K
V
V
A
--
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
----
A
S
NGKLI
V
P
P
E
-----
D
R
K
-
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
-
P
L
T
N
M
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
----
H
H
V
L
N
H
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
--
E
--
I
--
N
E
L
E
G
K
V
T
N
---
E
G
V
V
I
-
G
---------------
S
L
R
----
F
---
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
---
S
K
DVI
K
D
D
---
S
---
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
-
E
E
E
I
F
T
Y
S
D
H
P
I
H
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
--------
24
PsiBlast_CBE
78.85
40%
-103
- C1 -
4KI0
4
?
A:
[4-320]
----------
V
Q
L
Q
N
V
T
K
A
W
---
G
-
E
V
V
V
--
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
-----
T
P
P
A
-----
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
----
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
SP
K
--
M
--
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
-
E
L
P
-
M
P
N
R
Q
Q
V
W
L
P
V
E
S
R
D
----
V
---
Q
V
---
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
---
S
D
---
I
A
D
---
V
---
I
---
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
-
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
40
PsiBlast_CBE
78.67
36%
-116
- C1 -
1OXV
5
?
B:
[2-315]
--------
V
R
I
I
V
K
N
V
S
K
V
F
-
K
K
G
-
K
V
V
A
--
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
----
A
S
NGKLI
V
P
P
E
-----
D
R
K
-
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
-
P
L
T
N
M
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
----
H
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
--
E
--
I
--
N
E
L
E
G
K
V
T
N
---
E
G
V
V
I
-
G
---------------
S
L
R
----
F
---
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
---
S
K
DVI
K
D
D
---
S
---
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
-
E
E
E
I
F
T
Y
S
D
H
P
I
H
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
N
-------
45
PsiBlast_CBE
78.53
36%
-111
- C1 -
1OXS
20
?
C:
[2-315]
--------
V
R
I
I
V
K
N
V
S
K
V
F
-
K
K
G
-
K
V
V
A
--
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
----
A
S
NGKLI
V
P
P
E
-----
D
R
K
-
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
-
P
L
T
N
M
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
----
H
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
--
E
--
I
--
N
E
L
E
G
K
V
T
N
---
E
G
V
V
I
-
G
---------------
S
L
R
----
F
---
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
---
S
K
DVI
K
D
D
---
S
---
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
-
E
E
E
I
F
T
Y
S
D
H
P
I
H
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
--------
19
PsiBlast_PDB
78.19
40%
-106
- C1 -
3RLF
3
MALK_ECOLI
A:
[4-320]
----------
V
Q
L
Q
N
V
T
K
A
W
---
G
-
E
V
V
V
--
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
-----
T
P
P
A
-----
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
----
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
SP
K
--
M
--
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
-
E
L
P
-
M
P
N
R
Q
Q
V
W
L
P
V
E
S
R
D
----
V
---
Q
V
---
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
---
S
D
---
I
A
D
---
V
---
I
---
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
-
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
28
PsiBlast_CBE
78.04
40%
-110
- C1 -
2AWO
2
MALK_ECOLI
C:
[4-320]
----------
V
Q
L
Q
N
V
T
-----------
V
--
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
-----
T
P
P
A
-----
E
R
G
-
V
G
M
V
----
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
----
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
SP
K
--
M
--
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
-
E
L
P
-
M
P
N
R
QQVWLP
V
E
S
R
D
----
V
---
Q
V
---
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
---
S
D
---
I
A
D
---
V
---
I
---
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
-
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
23
PsiBlast_CBE
77.88
40%
-105
- C1 -
4KI0
3
?
B:
[4-320]
----------
V
Q
L
Q
N
V
T
K
A
W
---
G
-
E
V
V
V
--
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
-----
T
P
P
A
-----
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
----
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
SP
K
--
M
--
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
-
E
L
P
-
M
P
N
R
QQVWLP
V
E
S
R
D
----
V
---
Q
V
---
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
---
S
D
---
I
A
D
---
V
---
I
---
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
-
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
18
PsiBlast_PDB
77.82
40%
-105
- C1 -
3PUX
5
MALK_ECOLI
A:
[4-320]
----------
V
Q
L
Q
N
V
T
K
A
W
---
G
-
E
V
V
V
--
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
-----
T
P
P
A
-----
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
----
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
SP
K
--
M
--
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
-
E
L
P
-
M
P
N
R
Q
Q
V
W
L
P
V
E
S
R
D
----
V
---
Q
V
---
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
---
S
D
---
I
A
D
---
V
---
I
---
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
-
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
36
PsiBlast_CBE
77.75
40%
-102
- C1 -
2R6G
2
MALK_ECOLI (first)
A:
[4-320]
----------
V
Q
L
Q
N
V
T
K
A
W
---
G
-
E
V
V
V
--
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
-----
T
P
P
A
-----
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
----
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
Q
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
SP
K
--
M
--
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
-
E
L
P
-
M
P
N
R
Q
Q
V
W
L
P
V
E
S
R
D
----
V
---
Q
V
---
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
---
S
D
---
I
A
D
---
V
---
I
---
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
-
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
31
PsiBlast_CBE
77.71
40%
-106
- C1 -
2AWN
2
MALK_ECOLI
B:
[4-320]
----------
V
Q
L
Q
N
V
T
K
A
W
---
G
-
E
V
V
V
--
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
-----
T
P
P
A
-----
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
----
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
SP
K
--
M
--
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
-
E
L
P
-
M
P
N
R
Q
Q
V
W
L
P
V
E
S
R
D
----
V
---
Q
V
---
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
---
S
D
---
I
A
D
---
V
---
I
---
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
-
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
55
PsiBlast_CBE
64.50
35%
-99
- C1 -
4YMU
2
?
J:
[1-238]
---------
M
I
F
V
N
D
V
Y
K
N
F
---
G
-
S
L
E
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
----
N
N
GKVN-
I
N
K
V
-----
R
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
----
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
--
K
--
I
--
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
63.85
35%
-101
- C1 -
4YMU
2
?
A:
[1-238]
---------
M
I
F
V
N
D
V
Y
K
N
F
---
G
-
S
L
E
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
----
N
N
GKVN-
I
N
K
V
-----
R
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
----
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
--
K
--
I
--
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
62.62
35%
-99
- C1 -
4YMV
1
?
A:
[1-238]
---------
M
I
F
V
N
D
V
Y
K
N
F
---
G
-
S
L
E
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
----
N
N
GKVN-
I
N
K
V
-----
R
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
----
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
--
K
--
I
--
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
60.67
36%
-102
- C1 -
3C4J
4
?
B:
[24-261]
---------
M
I
D
V
H
Q
L
K
K
S
F
---
G
-
S
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
N
-----
L
N
K
V
-----
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
----
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
--
V
--
F
-------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
60.39
38%
-99
- C1 -
1L2T
4
Y796_METJA
B:
[1-230]
---------
M
I
K
L
K
N
V
T
K
T
Y
-
K
M
G
-
E
E
I
I
YA
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
----
N
D
-----
L
D
D
D
ELTKI
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
-
P
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
AELE
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
E
K
L
R
G
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
60.32
36%
-99
- C1 -
2OLK
1
?
C:
[24-261]
---------
M
I
D
V
H
Q
L
K
K
S
F
---
G
-
S
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
N
-----
L
N
K
V
-----
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
----
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
--
V
--
F
-------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
60.22
36%
-99
- C1 -
2OLK
2
?
B:
[24-261]
---------
M
I
D
V
H
Q
L
K
K
S
F
---
G
-
S
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
N
-----
L
N
K
V
-----
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
----
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
--
V
--
F
-------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
59.62
36%
-104
- C1 -
2OLJ
4
?
A:
[24-261]
---------
M
I
D
V
H
Q
L
K
K
S
F
---
G
-
S
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
N
-----
L
N
K
V
-----
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
----
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
--
V
--
F
-------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
59.51
36%
-99
- C1 -
3C41
3
?
K:
[3-240]
---------
M
I
D
V
H
Q
L
K
K
S
F
---
G
-
S
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
N
-----
L
N
K
V
-----
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
----
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
--
V
--
F
-------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
59.45
36%
-98
- C1 -
2OLK
1
?
A:
[24-261]
---------
M
I
D
V
H
Q
L
K
K
S
F
---
G
-
S
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAK
D
T
N
-----
L
N
K
V
-----
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
----
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
--
V
--
F
-------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
58.96
38%
-102
- C1 -
3TIF
7
Y796_METJA
B:
[1-230]
---------
M
V
K
L
K
N
V
T
K
T
Y
-
K
M
G
-
E
E
I
I
YA
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
----
N
D
-----
L
D
D
D
ELTKI
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
-
P
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
AELE
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
E
K
L
R
G
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
58.76
36%
-97
- C1 -
2Q0H
4
?
B:
[24-261]
---------
M
I
D
V
H
Q
L
K
K
S
F
---
G
-
S
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
N
-----
L
N
K
V
-----
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
----
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
--
V
--
F
-------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
58.69
36%
-100
- C1 -
3C41
3
?
J:
[3-240]
---------
M
I
D
V
H
Q
L
K
K
S
F
---
G
-
S
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
N
-----
L
N
K
V
-----
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
----
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
--
V
--
F
-------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
58.67
38%
-97
- C1 -
1L2T
4
Y796_METJA
A:
[1-230]
---------
M
I
K
L
K
N
V
T
K
T
Y
-
K
M
G
-
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
----
N
D
-----
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
-
P
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
ELE
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
E
K
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
58.53
36%
-98
- C1 -
2Q0H
4
?
A:
[24-261]
---------
M
I
D
V
H
Q
L
K
K
S
F
---
G
-
S
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
N
-----
L
N
K
V
-----
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
----
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
--
V
--
F
-------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
57.71
36%
-94
- C1 -
2OLK
1
?
D:
[24-261]
---------
M
I
D
V
H
Q
L
K
K
S
F
---
G
-
S
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
N
-----
L
N
K
V
-----
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
----
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
--
V
--
F
-------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
57.30
38%
-96
- C1 -
3TIF
7
Y796_METJA
A:
[1-230]
---------
M
V
K
L
K
N
V
T
K
T
Y
-
K
M
G
-
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
----
N
D
-----
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
-
P
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
ELE
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
E
K
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
56.60
36%
-97
- C1 -
2OLJ
3
?
B:
[24-261]
---------
M
I
D
V
H
Q
L
K
K
S
F
---
G
-
S
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
N
-----
L
N
K
V
-----
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
----
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
--
V
--
F
-------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
56.59
36%
-96
- C1 -
3C4J
3
?
A:
[24-261]
---------
M
I
D
V
H
Q
L
K
K
S
F
---
G
-
S
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
N
-----
L
N
K
V
-----
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
----
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
--
V
--
F
-------------------------------------------------------------------------------------------------------------------------------------------------------