@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0650: (2016-01-13 )
MDIKGALNRIVNQLDLTTEEMQAVMRQIMTGQCTDAQIGAFLMGMRMKSETIDEIVGAVAVMRELADGVQLPTLKHVVDVVGTGGDGANIFNVSSAASFVVAAAGGKVAKHGNRAVSGKSGSADLLEAAGIYLELTSEQVARCIDTVGVGFMFAQVHHKAMKYAAGPRRELGLRTLFNMLGPLTNPAGVRHQVVGVFTQELCKPLAEVLKRLGSEHVLVVHSRDGLDEFSLAAATHIAELKDGEVREYEVRPEDFGIKSQTLMGLEVDSPQASLELIRDALGRRKTEAGQKAAELIVMNAGPALYAADLATSLHEGIQLAHDALHTGLAREKMDELVAFTAVYREENAQ
Atome Classification :
(42 SA)
.........10........20........30........40........50........60........70..-...-...80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.....-..270.-......280.......290.......300....-------...310-........320.......330.......340.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MD
I
K
G
A
L
N
R
I
V
N
Q
LDL
T
T
E
E
M
Q
A
V
M
R
Q
I
MTGQCT
D
A
Q
I
G
A
F
L
M
G
MRM
K
S
E
T
I
D
E
I
V
G
A
V
A
V
M
R
E
L
ADGVQL
P
T
-
L
K
H
-
V
V
D
V
VGTGGDG
A
N
I
F
NVSSA
A
S
F
V
V
A
AAGGKVAKHGNRAVSGKSG
S
A
D
L
L
E
AA
G
I
Y
L
EL
T
S
E
Q
V
A
R
C
I
D
T
V
G
V
G
F
M
F
A
Q
V
H
H
K
A
M
K
YAAGP
R
R
EL
G
L
R
T
L
F
N
M
LGPLTNP
A
G
V
R
H
Q
V
V
G
V
F
T
Q
E
L
C
K
P
L
A
E
V
L
K
R
LGSE
H
V
L
V
V
HSRDG
L
D
E
F
S
L
A
A
A
T
H
I
A
ELKDGE
V
R
E
Y
EVRPEDFGIKS
Q
T
L
M
G
L
EV-DS
P
Q
A
S
-
L
E
L
I
R
D
A
LGRRKTEAGQKA
A
E
L
I
V
MNAGP
A
L
Y
A
-------
A
D
L
A
T
--
S
L
H
E
G
I
Q
L
A
H
D
A
L
H
T
G
L
A
R
E
K
M
D
E
L
V
A
F
T
A
V
Y
REENAQ
1
PsiBlast_PDB
96.31
59%
-114
- C11 -
4YI7
1
?
A:
[18-361]
-
N
I
Q
Q
A
L
N
H
I
T
K
N
I
H
L
T
Q
A
Q
M
E
D
V
M
R
S
I
M
Q
G
E
A
T
E
A
Q
I
G
A
L
M
M
G
L
R
M
K
G
E
S
I
D
E
I
T
A
A
A
R
V
M
R
E
L
A
I
K
I
D
V
S
D
-
I
Q
Y
-
L
V
D
I
V
G
T
G
G
D
--
N
L
F
N
V
S
T
A
S
S
F
V
I
A
A
A
G
A
T
I
A
K
H
G
N
R
-------
S
S
D
L
L
E
Q
A
G
I
N
L
D
L
D
M
Q
Q
T
E
R
C
I
R
E
M
G
V
G
F
L
F
A
------
M
K
Y
A
V
G
P
R
R
E
L
G
I
R
S
I
F
N
L
L
G
P
L
T
N
P
A
G
V
K
R
F
V
I
G
V
F
S
D
E
L
C
R
P
I
A
E
V
M
K
Q
L
G
A
E
H
V
M
V
V
H
S
K
D
G
L
D
E
I
S
L
A
S
Q
T
Y
I
A
E
L
K
N
G
E
V
T
E
W
V
L
N
P
E
D
V
N
I
P
S
Q
T
L
S
G
L
I
V
-
E
D
S
N
A
S
-
L
K
L
I
K
D
A
L
G
R
K
K
S
D
I
G
E
K
A
A
N
M
I
A
L
N
A
G
A
G
I
Y
V
-------
S
G
L
A
T
--
S
Y
K
Q
G
V
A
L
A
H
D
I
I
Y
G
G
Q
A
L
E
K
M
S
I
L
S
E
F
T
K
A
L
K
E
----
2
PsiBlast_PDB
88.04
47%
-114
- C11 -
4HKM
3
TRPD_XANCP
A:
[9-339]
-----
A
L
Q
R
T
I
E
H
R
E
I
F
H
D
E
M
V
D
L
M
R
Q
I
M
R
G
E
V
S
D
A
M
V
S
A
I
L
T
G
L
R
V
K
K
E
T
I
G
E
I
A
G
A
A
T
V
M
R
E
F
S
R
R
V
E
V
T
D
-
R
R
H
-
M
V
D
I
V
G
T
------
T
F
N
I
S
T
C
A
M
F
V
A
A
A
G
G
A
K
V
A
K
H
G
---------
S
A
D
A
L
E
A
L
G
A
V
I
E
L
Q
P
E
Q
V
A
A
S
L
A
Q
T
G
I
G
F
M
Y
A
P
V
H
H
P
A
M
K
V
V
A
P
V
R
R
E
M
G
V
R
T
I
F
N
I
L
G
P
L
T
N
P
A
G
S
P
N
I
L
M
G
V
F
H
P
D
L
V
G
I
Q
A
R
V
L
Q
E
L
G
A
E
R
A
L
V
V
W
G
R
D
G
M
D
E
L
S
L
G
A
G
T
L
V
G
E
L
R
D
G
Q
V
H
E
Y
E
V
H
P
E
D
F
G
I
A
M
S
A
------A
E
S
R
A
M
L
-
L
Q
V
L
D
N
V
P
G
--------
P
A
L
D
I
V
A
L
N
A
G
A
A
L
Y
V
-------
A
G
V
A
D
--
S
I
A
D
G
I
V
R
A
R
Q
V
L
A
D
G
S
A
R
A
C
L
D
A
Y
V
A
F
T
Q
Q
A
T
A
----
105
HHSearch
86.43
41%
-96
* C11 *
2ELC
4
TRPD_THET8
A:
[2-328]
----
D
A
V
K
K
A
I
L
G
E
V
L
E
E
E
E
A
Y
E
V
M
R
A
L
M
A
G
E
V
S
P
V
R
A
A
G
L
L
V
A
L
S
L
R
G
E
R
P
H
E
I
A
A
M
A
R
A
M
R
E
A
A
R
P
L
R
V
H
R
--
R
P
-
L
L
D
I
V
G
T
G
G
D
G
K
G
L
M
N
L
S
T
L
A
A
L
V
A
A
A
G
G
V
A
V
A
K
H
G
N
R
A
A
S
S
R
A
G
S
A
D
L
L
E
A
L
G
V
D
L
E
A
P
P
E
R
V
G
E
A
I
E
E
L
G
F
G
F
L
F
A
R
V
F
H
P
A
M
R
H
V
A
P
V
R
A
E
L
G
V
R
T
V
F
N
L
L
G
P
L
T
N
P
A
G
A
D
A
Y
V
L
G
V
F
S
P
E
W
L
A
P
M
A
E
A
L
E
R
L
G
A
-
R
G
L
V
V
H
G
-
E
G
A
D
E
L
V
L
-
G
E
N
R
V
V
E
V
G
K
G
---
A
Y
A
L
T
P
E
E
V
G
L
K
R
A
P
L
E
A
L
K
G
-
G
G
P
E
E
N
-
A
A
L
A
R
R
L
L
K
G
E
E
---
K
G
P
L
A
D
A
V
A
L
A
A
G
A
G
F
Y
A
-------
A
G
K
T
P
--
S
L
K
E
G
V
A
L
A
R
E
V
L
A
S
G
E
A
Y
L
L
L
E
R
Y
V
A
F
L
R
A
-------
44
PsiBlast_CBE
85.40
39%
-100
- C11 -
4OWN
9
TRPD_MYCTU
B:
[31-366]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
-
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
G
----
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
SR
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
L
-----
15
PsiBlast_PDB
85.09
39%
-95
- C11 -
4GIU
9
TRPD_MYCTU
A:
[31-366]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
G
----
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
LSSR
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
-------
102
HHSearch
84.80
34%
-94
- C11 -
1VQU
2
TRPD2_NOSS1
A:
[25-374]
T
S
W
Y
L
L
L
Q
Q
L
I
D
G
E
S
L
S
R
S
Q
A
A
E
L
M
Q
G
W
L
S
E
A
V
P
P
E
L
S
G
A
I
L
T
A
L
N
F
K
G
V
S
A
D
E
L
T
G
M
A
E
V
L
Q
S
Q
S
K
M
---
T
N
S
P
F
S
-
I
I
D
T
C
G
T
G
---
S
S
T
F
N
I
S
T
A
V
A
F
V
A
A
A
Y
G
V
P
V
A
K
H
G
N
R
--
S
S
L
T
G
S
A
D
V
L
E
A
L
G
V
N
L
G
A
S
P
E
K
V
Q
A
A
L
Q
E
V
G
I
T
F
L
F
A
P
G
W
H
P
A
L
K
A
V
A
T
L
R
R
T
L
R
I
R
T
V
F
N
L
L
G
P
L
V
N
P
L
R
P
T
G
Q
V
V
G
L
F
T
P
K
L
L
T
T
V
A
Q
A
L
D
N
L
G
K
Q
K
A
I
V
L
H
G
R
E
R
L
D
E
A
G
L
G
D
L
T
D
L
A
V
L
S
D
G
E
L
Q
L
T
T
I
N
P
Q
E
V
G
V
T
P
A
P
I
G
A
L
R
G
-
G
D
V
Q
E
N
-
A
E
I
L
K
A
V
L
Q
G
K
G
---
T
Q
A
Q
Q
D
A
V
A
L
N
A
A
L
A
L
Q
V
-------
A
G
A
V
P
LL
D
H
A
Q
G
V
S
V
A
K
E
I
L
Q
T
G
T
A
W
A
K
L
A
Q
L
V
Y
F
L
G
N
-------
18
PsiBlast_PDB
84.80
39%
-96
- C11 -
4OWQ
6
TRPD_MYCTU
A:
[31-366]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
G
----
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
SSR
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
------
45
PsiBlast_CBE
84.78
39%
-99
- C11 -
4OWM
5
TRPD_MYCTU
B:
[31-366]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
--
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
G
----
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
SR
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
L
E
----
50
PsiBlast_CBE
84.77
39%
-97
- C11 -
3TWP
5
TRPD_MYCTU
D:
[30-365]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
----
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
HAGLSSR
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
------
68
PsiBlast_CBE
84.74
39%
-96
- C11 -
3QQS
4
TRPD_MYCTU
A:
[30-365]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
----
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
SSR
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
------
56
PsiBlast_CBE
84.69
39%
-99
- C11 -
3R6C
5
TRPD_MYCTU
B:
[30-365]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
----
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
HAGLSSR
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
------
66
PsiBlast_CBE
84.67
39%
-96
- C11 -
3QQS
5
TRPD_MYCTU
C:
[30-365]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
-
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
----
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
--------
65
PsiBlast_CBE
84.65
39%
-97
- C11 -
3QR9
2
TRPD_MYCTU
A:
[30-365]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
----
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
SR
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
L
-----
61
PsiBlast_CBE
84.65
39%
-97
- C11 -
3QS8
5
TRPD_MYCTU
C:
[30-365]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
----
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
HAGLSSR
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
------
71
PsiBlast_CBE
84.64
39%
-97
- C11 -
4GKM
10
TRPD_MYCTU
B:
[32-367]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
G
----
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
HAGLSSR
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
------
57
PsiBlast_CBE
84.59
39%
-97
- C11 -
3R6C
5
TRPD_MYCTU
A:
[30-365]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
----
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
LSSR
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
------
20
PsiBlast_PDB
84.48
39%
-97
- C11 -
4OWU
7
TRPD_MYCTU
A:
[31-366]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
G
----
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
SR
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
------
49
PsiBlast_CBE
84.45
39%
-100
- C11 -
3UU1
5
TRPD_MYCTU
C:
[30-365]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
---
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
----
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
HAGL----
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
------
42
PsiBlast_CBE
84.43
39%
-95
- C11 -
4OWU
6
TRPD_MYCTU
B:
[31-366]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
G
----
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
HAGLSSR
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
L
-----
16
PsiBlast_PDB
84.42
39%
-95
- C11 -
4OWM
5
TRPD_MYCTU
A:
[31-366]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
G
----
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
SSR
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
------
58
PsiBlast_CBE
84.37
39%
-96
- C11 -
3QSA
4
TRPD_MYCTU
B:
[30-365]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
----
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
HAGLSSR
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
L
E
----
72
PsiBlast_CBE
84.24
39%
-96
- C11 -
4GKM
8
TRPD_MYCTU
A:
[32-367]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
G
----
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
LSSR
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
------
13
PsiBlast_PDB
84.23
39%
-93
- C11 -
4N8Q
1
TRPD_MYCTU
A:
[31-366]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
-
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
----
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
SSR
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
------
43
PsiBlast_CBE
84.14
39%
-96
- C11 -
4OWO
7
TRPD_MYCTU
B:
[31-366]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
G
----
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
SR
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
L
E
----
55
PsiBlast_CBE
84.11
39%
-99
- C11 -
3R88
3
TRPD_MYCTU
A:
[30-365]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
----
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
LS--
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
------
17
PsiBlast_PDB
84.10
39%
-96
- C11 -
4OWO
7
TRPD_MYCTU
A:
[31-366]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
G
----
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
SR
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
------
54
PsiBlast_CBE
84.09
39%
-99
- C11 -
3R88
4
TRPD_MYCTU
B:
[30-365]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
----
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
HAGLS--
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
------
67
PsiBlast_CBE
84.03
39%
-96
- C11 -
3QQS
4
TRPD_MYCTU
B:
[30-365]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
----
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
GLSSR
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
------
41
PsiBlast_CBE
84.02
39%
-97
- C11 -
4OWV
3
TRPD_MYCTU
B:
[31-366]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
--
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
G
----
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
SSR
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
------
12
PsiBlast_PDB
83.98
39%
-97
- C11 -
4N5V
7
TRPD_MYCTU
A:
[31-366]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
----
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
SS-
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
------
59
PsiBlast_CBE
83.81
39%
-96
- C11 -
3QSA
4
TRPD_MYCTU
A:
[30-365]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
----
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
SSR
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
------
69
PsiBlast_CBE
83.75
39%
-96
- C11 -
4M0R
2
TRPD_MYCTO
B:
[32-367]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
-----
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
-
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
G
----
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
SR
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
L
E
----
39
PsiBlast_CBE
83.71
39%
-99
- C11 -
4N8Q
1
TRPD_MYCTU
B:
[31-366]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
----
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
----
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
SR
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
L
A
----
34
PsiBlast_CBE
83.49
34%
-99
- C11 -
3GBR
7
TRPD_SULSO
B:
[2-330]
-
N
I
N
E
I
L
K
K
L
I
N
K
S
D
L
E
I
N
E
A
E
E
L
A
K
A
I
I
R
G
E
V
P
E
I
L
V
S
A
I
L
V
A
L
R
M
K
G
E
S
K
N
E
I
V
G
F
A
R
A
M
R
E
L
A
I
K
I
D
V
P
----
N
-
A
I
D
T
A
G
T
G
G
G
G
L
G
T
V
N
V
S
T
A
S
A
I
L
L
S
L
V
N
-
P
V
A
K
H
G
N
R
A
V
S
G
K
S
G
S
A
D
V
L
E
A
L
G
Y
N
I
I
V
P
P
E
R
A
K
E
L
V
N
K
T
N
F
V
F
L
S
A
Q
Y
Y
H
P
A
M
K
N
V
A
N
V
R
K
T
L
G
I
R
T
I
F
N
I
L
G
P
L
T
N
P
A
N
A
K
Y
Q
L
M
G
V
F
S
K
D
H
L
D
L
L
S
K
S
A
Y
E
L
D
F
N
K
I
I
L
V
Y
G
E
P
G
I
D
E
V
S
P
I
G
N
T
F
M
K
I
V
S
K
R
G
I
E
E
V
K
L
N
V
T
D
F
G
I
S
P
I
P
I
E
K
L
I
V
-
N
S
A
E
D
S
A
I
K
I
V
R
A
F
L
G
K
-----
D
E
H
V
A
E
F
I
K
I
N
T
A
V
A
L
F
A
-------
L
D
R
V
G
--
D
F
R
E
G
Y
E
Y
A
D
H
L
I
E
K
S
L
--
D
K
L
N
E
I
I
S
M
N
G
D
V
T
K
L
K
T
I
40
PsiBlast_CBE
83.44
39%
-98
- C11 -
4N5V
6
TRPD_MYCTU
B:
[31-366]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
----
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
HAGLSS-
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
L
A
----
14
PsiBlast_PDB
83.37
39%
-95
- C11 -
4N93
6
TRPD_MYCTU
A:
[31-366]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
----
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
SS-
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
------
38
PsiBlast_CBE
83.31
39%
-98
- C11 -
4N93
5
TRPD_MYCTU
B:
[31-366]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
----
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
HAGLSS-
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
------
70
PsiBlast_CBE
83.14
39%
-96
- C11 -
4M0R
4
TRPD_MYCTO
A:
[32-367]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
---
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
G
----
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
SSR
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
-------
35
PsiBlast_CBE
82.76
41%
-97
- C11 -
2ELC
2
TRPD_THET8
D:
[21-326]
-----------------------
V
M
R
A
L
M
A
G
E
V
S
P
V
R
A
A
G
L
L
V
A
L
S
L
R
G
E
R
P
H
E
I
A
A
M
A
R
A
M
R
E
A
A
R
P
L
R
V
-
H
-
R
R
P
-
L
L
D
I
V
G
T
G
G
D
G
K
G
L
M
N
L
S
T
L
A
A
L
V
A
A
A
G
G
V
A
V
A
K
H
G
N
R
A
A
S
S
R
A
G
S
A
D
L
L
E
A
L
G
V
D
L
E
A
P
P
E
R
V
G
E
A
I
E
E
L
G
F
G
F
L
F
A
R
V
F
H
P
A
M
R
H
V
A
P
V
R
A
E
L
G
V
R
T
V
F
N
L
L
G
P
L
T
N
P
A
G
A
D
A
Y
V
L
G
V
F
S
P
E
W
L
A
P
M
A
E
A
L
E
R
L
G
A
R
G
-
L
V
V
H
G
-
E
G
A
D
E
L
V
L
-
G
E
N
R
V
V
E
V
G
K
G
---
A
Y
A
L
T
P
E
E
V
G
L
K
R
A
P
L
E
A
L
K
G
-
G
G
P
E
E
N
-
A
A
L
A
R
R
L
L
---
K
G
E
E
K
G
P
L
A
D
A
V
A
L
A
A
G
A
G
F
Y
A
-------
A
G
K
T
P
--
S
L
K
E
G
V
A
L
A
R
E
V
L
A
S
G
E
A
Y
L
L
L
E
R
Y
V
A
F
L
R
A
-------
19
PsiBlast_PDB
82.56
39%
-102
- C11 -
4OWS
2
TRPD_MYCTU
A:
[31-366]
------
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
-
V
P
D
D
A
V
D
V
V
G
T
G
---
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
---
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
S
S
-
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
-
G
D
A
Q
A
N
-
A
A
A
V
R
A
V
L
G
G
A
R
G
----
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
SSR
A
E
W
L
P
--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
------
11
PsiBlast_PDB
82.23
41%
-97
- C11 -
2ELC
4
TRPD_THET8
A:
[21-326]
-----------------------
V
M
R
A
L
M
A
G
E
V
S
P
V
R
A
A
G
L
L
V
A
L
S
L
R
G
E
R
P
H
E
I
A
A
M
A
R
A
M
R
E
A
A
R
P
L
R
V
-
H
-
R
R
P
-
L
L
D
I
V
G
T
G
G
D
G
K
G
L
M
N
L
S
T
L
A
A
L
V
A
A
A
G
G
V
A
V
A
K
H
G
N
R
A
A
S
S
R
A
G
S
A
D
L
L
E
A
L
G
V
D
L
E
A
P
P
E
R
V
G
E
A
I
E
E
L
G
F
G
F
L
F
A
R
V
F
H
P
A
M
R
H
V
A
P
V
R
A
E
L
G
V
R
T
V
F
N
L
L
G
P
L
T
N
P
A
G
A
D
A
Y
V
L
G
V
F
S
P
E
W
L
A
P
M
A
E
A
L
E
R
L
G
A
R
G
-
L
V
V
H
G
-
E
G
A
D
E
L
V
L
-
G
E
N
R
V
V
E
V
G
K
G
---
A
Y
A
L
T
P
E
E
V
G
L
K
R
A
P
L
E
A
L
K
G
-
G
G
P
E
E
N
-
A
A
L
A
R
R
L
L
---
K
G
E
E
K
G
P
L
A
D
A
V
A
L
A
A
G
A
G
F
Y
A
-------
A
G
K
T
P
--
S
L
K
E
G
V
A
L
A
R
E
V
L
A
S
G
E
A
Y
L
L
L
E
R
Y
V
A
F
L
R
A
-------
36
PsiBlast_CBE
81.94
41%
-95
- C11 -
2ELC
3
TRPD_THET8
C:
[21-326]
-----------------------
V
M
R
A
L
M
A
G
E
V
S
P
V
R
A
A
G
L
L
V
A
L
S
L
R
G
E
R
P
H
E
I
A
A
M
A
R
A
M
R
E
A
A
R
P
L
R
V
-
H
-
R
R
P
-
L
L
D
I
V
G
T
G
G
D
G
K
G
L
M
N
L
S
T
L
A
A
L
V
A
A
A
G
G
V
A
V
A
K
H
G
N
R
A
A
S
S
R
A
G
S
A
D
L
L
E
A
L
G
V
D
L
E
A
P
P
E
R
V
G
E
A
I
E
E
L
G
F
G
F
L
F
A
R
V
F
H
P
A
M
R
H
V
A
P
V
R
A
E
L
G
V
R
T
V
F
N
L
L
G
P
L
T
N
P
A
G
A
D
A
Y
V
L
G
V
F
S
P
E
W
L
A
P
M
A
E
A
L
E
R
L
G
A
R
G
-
L
V
V
H
G
-
E
G
A
D
E
L
V
L
-
G
E
N
R
V
V
E
V
G
K
G
---
A
Y
A
L
T
P
E
E
V
G
L
K
R
A
P
L
E
A
L
K
G
-
G
G
P
E
E
N
-
A
A
L
A
R
R
L
L
---
K
G
E
E
K
G
P
L
A
D
A
V
A
L
A
A
G
A
G
F
Y
A
-------
A
G
K
T
P
--
S
L
K
E
G
V
A
L
A
R
E
V
L
A
S
G
E
A
Y
L
L
L
E
R
Y
V
A
F
L
R
A
-------