@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0782: (2016-01-19 )
MFKASHVLQGEDQTRSAAEFFPVISANYAVDEEAYLGELLQLADPGPDGIEAIRRNARALIETVRSRDNAVDTLDALLRQYSLDTQEGLMLMCLAEALLRVPDAATADALIRDKLSAADWQRHLGQSDNVLVNFAAWGLVMTGKVVNIDERTDGRAPSVISRLVQRSGEPVIRAAMNQAMKLMGKQFVLGRTISEALKNGRPCREQGYTYSFDMLGEAALTAADAEKYMADYRQAIDTVGAEPQVGPGPRPSISIKLSALHPRYEVAQRERVLSELFANVLELAVRARKLNVGITIDAEEADRLELSLELYEKLMRDPAIAGWGEFGLVIQAYSKRCLPVLVWLTLLGRELGARIPLRLVKGAYWDSEIKQCQVQGADGYPVYTRKEGTDTSYLACARYLLSEHTRGVIYPQFASHNAHTVTAILALADEARAAGGEERDFEFQRLHGMGDALYDTVIEKYRRNVRIYAPVGAHKDLLPYLVRRLLENGANSSFVHKLVDPRVPVETLIQHPVTQLRQFKTLANDRIPLPQAIFGAGRKNSQGINMNIQNQWNELELAYKPHLTRQWQAAPIVNGEKLSGPAHEVRCPYDLERLVGSVQYASAEQAGKALDVLQAAWPRWSATPVDERAGILERLADLLEAQRGELMALCTLEAGKSLQDGIDEIREAVDFCRYYAQQARQRLVREELRGPTGERNELFYEGRGIFACVSPWNFPLAIFLGQISAALVAGNTVLAKPAEQTSLIAARTVELMFEAGLPKDVIALLPGDGATLGGVFCRDARVAGVAFTGSTDTARIINRQLAEKPGAIATLIAETGGQNAMIVDSTALPEQVIKDAVQSAFTSAGQRCSALRVMYVQQDIAERVIELLKGAMAELKVGPTEVRVSDVGPVIDAEAKAGLEQHIAALKAAGKLIAETKVPGNLNGHFVAPVAFEISGIDELKKENFGPVLHVVRYAAQDLEKVVQAINATGFGLTMGVHSRNEETARRIEELARVGNLYINRNQIGAVVGVQPFGGHGLSGTGPKAGGPNYLLRFVSERTTSVNTTAVGGNASLLSLADAE
Atome Classification :
(32 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200........210.......220.......230.......240..-.....-250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460--.-......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.....--..570........580.-....-..590.......600.......610.......620.......630.......640.......650.......660.......670.......-680..-...-..690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.-.-.....---800.....--..810.......820.......830.......840.......850.......860.......870......-.880.......890.......900.......910.....-..920.......930-.......----940..-.....950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MFK
A
S
HVLQGEDQTR
S
A
A
E
F
F
P
V
ISANYAVD
E
E
A
Y
L
G
E
L
L
Q
LADPGP
D
G
I
E
A
I
R
R
N
A
R
A
L
I
E
T
V
R
SRDN
A
V
D
T
L
D
A
L
L
R
QYSL
D
T
QEG
L
M
L
M
C
L
A
E
A
L
LRVPDA
A
T
A
D
A
L
I
R
D
KL
S
A
A
D
W
Q
R
HLGQSD
N
V
L
V
N
FAAW
G
L
V
M
TG
K
V
V
N
IDERTDGR
A
P
S
V
I
S
R
L
V
Q
RSG
E
P
V
I
R
A
A
M
N
Q
A
M
K
L
M
G
KQFVL
G
R
T
I
S
E
A
L
KNG-RP
C
R
EQG
Y
T
Y
S
F
D
M
L
G
E
A
AL
T
A
A
D
A
E
K
Y
M
A
D
Y
R
Q
A
I
D
TVGAEPQ-VGPGP-R
P
S
I
S
I
K
L
S
ALHP
R
Y
E
V
A
Q
R
E
R
V
L
S
E
L
F
A
N
V
L
E
L
A
V
R
A
R
K
L
N
V
G
I
T
I
DAEEA
D
R
L
E
L
S
L
E
L
Y
E
K
L
MRDPAIAGW
G
E
F
G
L
V
I
Q
A
Y
SKR
C
L
P
V
L
V
W
L
T
L
L
G
R
E
LGARI
P
L
R
L
VKGAY
W
D
S
E
I
K
Q
C
Q
VQGADGY
P
V
Y
TRKEGTD
T
S
Y
L
A
C
A
R
Y
L
L
S
EHTR
G
V
IYPQFASHNA
H
T
V
T
A
I
L
A
L
A
D
E
A
RAAGGEERD
F
E
F
Q
R
L
HGM
G
D
A
L
Y
D
T
V
I
E
K
Y
R--R-N
V
R
I
Y
A
PVGAHK
D
L
L
P
Y
L
V
R
R
L
L
ENGA
N
S
S
F
V
H
K
LVDPRV
P
V
E
T
L
I
Q
H
P
V
T
Q
L
R
Q
F
K
T
L
ANDRIPL
P
Q
A
I
FGAGRKNSQGI
N
M
N
IQNQWN
E
L
E
L
A
YKPHLTRQW--QAAP-IVNGEKLSGPAH-EVRC-
P
Y
D
L
E
R
L
V
G
S
VQYA
S
A
E
QAG
K
A
L
D
V
L
Q
A
AWPRWSAT
P
V
D
E
R
A
G
I
L
E
R
L
A
D
L
L
E
AQRG
E
L
M
A
L
C
T
LEAG
K
S
L
Q
D
G
I
D
E
I
R
E
A
V
D
F
C
R
Y
Y
A
Q
Q
A
-
R
Q
R
L
V
-
R
E
E
-LRGPTGERN
E
L
F
YEG
R
G
I
F
A
C
VSPWN
F
P
L
A
I
F
L
G
Q
I
S
A
A
L
VAGN
T
V
LAKPA
E
Q
T
S
L
I
A
A
R
T
V
E
L
M
F
EAGL
P
K
D
V
I
A
LLPGDGATLG
G
V
F
CRDA
R
V
A
G
V
A
FTGST
D
T
-
A
-
R
I
I
N
R
---
Q
L
AEKPG
A
--
I
A
T
L
I
A
ETGGQ
N
A
M
I
VDSTA
L
P
E
Q
V
I
K
D
A
V
Q
S
A
F
T
S
AG
Q
R
C
S
A
L
R
V
M
Y
V
Q
Q
D
I
A
E
R
V
I
E
L
L
K
G
A
M
A
E
LKVG-P
T
E
V
R
VSDVGPVI
D
A
E
A
K
A
G
L
E
Q
H
I
A
A
L
K
A
A
G
K
L
I
A
ETK-VPGNLNG
H
F
V
A
P
V
A
F
-
E
IS
G
I
D
E
----
L
K
KEN-F
G
P
V
L
H
V
V
R
Y
A
A
Q
D
L
E
K
V
V
Q
A
INATGF
G
L
T
M
G
VHSR
N
E
E
T
A
R
R
I
E
E
L
A
R
V
G
N
L
Y
I
NRNQ
I
G
A
V
V
GVQPFGGHGLSGTGPKAG
G
P
N
Y
L
L
R
F
V
S
E
RTTSVN
T
T
AVGGN
A
S
L
L
S
LADAE
74
Fugue
95.98
51%
-86
- C3 -
4Q71
7
?
A:
[3-990]
----------------
M
P
N
I
P
P
P
F
T
A
P
Y
A
P
D
D
A
E
I
A
A
R
L
L
P
A
S
H
L
S
P
P
Q
E
A
R
I
H
R
T
A
T
R
L
I
E
A
I
R
K
R
L
G
G
---
V
E
D
M
L
R
E
F
A
L
S
T
K
E
G
L
A
L
M
V
L
A
E
A
L
L
R
V
P
D
A
R
T
A
D
Q
F
I
E
D
K
L
G
E
G
D
F
I
H
H
E
T
K
S
T
A
F
L
V
N
A
S
A
W
A
-----
R
V
I
Q
P
G
E
T
P
D
G
----
T
I
G
R
L
V
K
R
L
G
A
P
A
V
R
T
A
T
R
Q
A
M
R
L
M
G
N
H
F
V
L
G
E
T
I
E
Q
A
L
E
R
G
-
K
P
--
G
Q
K
T
R
Y
S
F
D
M
L
G
E
G
A
R
T
A
A
D
A
R
R
Y
F
D
A
Y
A
S
A
I
E
T
I
G
K
A
A
G
-
N
H
A
L
P
D
R
P
G
I
S
V
K
L
S
A
L
H
P
R
F
E
A
I
S
R
A
R
V
M
V
E
L
V
P
Q
L
L
D
L
A
Q
R
A
K
A
H
D
L
N
F
T
V
D
A
E
E
A
D
R
L
E
L
S
L
D
V
I
A
A
T
L
A
D
P
S
L
K
G
W
D
G
F
G
L
A
I
Q
A
Y
Q
K
R
A
S
A
V
I
D
Y
V
D
A
L
A
R
A
H
D
R
K
L
M
V
R
L
V
K
G
A
Y
W
D
T
E
I
K
R
A
Q
E
R
G
L
D
G
Y
P
V
F
T
R
K
A
M
T
D
L
N
Y
V
A
C
A
S
K
L
L
A
L
R
P
R
--
I
F
P
Q
F
A
T
H
N
A
L
T
V
A
T
V
L
E
M
A
-------
E
G
S
S
G
F
E
F
Q
R
L
H
G
M
G
E
A
L
Y
E
Q
L
A
K
D
H
A
--
D
I
A
Y
R
T
Y
A
P
V
G
S
H
R
D
L
L
A
Y
L
V
R
R
L
L
E
N
G
A
N
S
S
F
V
A
Q
A
A
D
Y
R
V
P
V
P
A
L
L
Q
R
P
A
D
A
I
V
R
P
Q
A
A
A
H
P
R
I
P
L
P
C
D
L
F
A
P
E
R
R
N
S
R
G
V
E
F
G
A
R
T
A
L
D
Q
L
L
T
D
V
K
A
E
I
A
D
----------------------------------------
A
T
P
D
Q
A
H
A
A
V
A
A
A
R
A
G
F
A
G
W
S
R
T
P
A
G
I
R
A
A
A
L
E
Q
A
A
H
L
L
E
S
R
S
A
H
F
I
A
L
L
Q
R
E
G
G
K
T
L
D
D
A
L
S
E
L
R
E
A
A
D
F
C
R
Y
Y
A
A
Q
G
-
R
K
L
F
G
-
S
E
T
A
M
P
G
P
T
G
E
S
N
A
L
T
M
R
G
R
G
V
F
V
A
I
S
P
W
N
F
P
L
A
I
F
L
G
Q
V
T
A
A
L
M
A
G
N
S
V
V
A
K
P
A
E
Q
T
P
R
I
A
R
E
A
V
A
L
L
H
E
A
G
I
P
K
S
A
L
Y
L
V
T
G
D
-
G
R
I
G
A
A
L
T
A
H
P
D
I
A
G
V
V
F
T
G
S
T
E
V
-
A
-
R
S
I
N
R
---
A
L
A
A
K
D
G
P
--
I
V
P
L
I
A
E
T
G
G
I
N
A
M
I
A
D
A
T
A
L
P
E
Q
V
A
D
W
V
V
T
S
A
F
R
S
A
G
Q
R
C
S
A
L
R
L
L
F
V
Q
E
D
V
A
D
R
M
I
E
M
V
A
G
A
A
R
E
L
K
I
G
-
D
P
S
D
V
A
T
H
V
G
P
V
I
D
V
E
A
K
Q
R
L
D
A
H
I
A
R
M
K
T
E
A
R
L
H
F
A
G
P
-
A
P
---
E
G
C
F
V
A
P
H
I
F
-
E
L
T
E
A
G
Q
----
L
T
E
E
V
-
F
G
P
I
L
H
V
V
R
Y
R
P
E
N
L
E
R
V
L
R
A
I
E
R
T
G
Y
G
L
T
L
G
V
H
S
R
I
D
D
S
I
E
A
I
I
D
R
V
Q
V
G
N
I
Y
V
N
R
N
M
I
G
A
V
V
G
V
Q
P
F
G
G
N
G
L
S
G
T
G
P
K
A
G
G
P
H
Y
L
A
R
F
A
T
E
Q
T
V
T
I
N
T
A
A
A
-------------
84
HHSearch
95.13
51%
-86
- C3 -
3HAZ
13
?
A:
[4-991]
-----------------
P
N
I
P
P
P
F
T
A
P
Y
A
P
D
D
A
E
I
A
A
R
L
L
P
A
S
H
L
S
P
P
Q
E
A
R
I
H
R
T
A
T
R
L
I
E
A
I
R
K
R
--
R
L
G
G
V
E
D
M
L
R
E
F
A
L
S
T
K
E
G
L
A
L
M
V
L
A
E
A
L
L
R
V
P
D
A
R
T
A
D
Q
F
I
E
D
K
L
G
E
G
D
F
I
H
H
E
T
K
S
T
A
F
L
V
N
A
S
A
W
A
----
A
R
V
I
Q
P
G
E
----
T
P
D
G
T
I
G
R
L
V
K
R
L
G
A
P
A
V
R
T
A
T
R
Q
A
M
R
L
M
G
N
H
F
V
L
G
E
T
I
E
Q
A
L
E
R
G
K
P
R
S
G
-
Q
K
T
R
Y
S
F
D
M
L
G
E
G
A
R
T
A
A
D
A
R
R
Y
F
D
A
Y
A
S
A
I
E
T
I
G
K
A
A
G
N
H
A
L
P
D
-
R
P
G
I
S
V
K
L
S
A
L
H
P
R
F
E
A
I
S
R
A
R
V
M
V
E
L
V
P
Q
L
L
D
L
A
Q
R
A
K
A
H
D
L
N
F
T
V
D
A
E
E
A
D
R
L
E
L
S
L
D
V
I
A
A
T
L
A
D
P
S
L
K
G
W
D
G
F
G
L
A
I
Q
A
Y
Q
K
R
A
S
A
V
I
D
Y
V
D
A
L
A
R
A
H
D
R
K
L
M
V
R
L
V
K
G
A
Y
W
D
T
E
I
K
R
A
Q
E
R
G
L
D
G
Y
P
V
F
T
R
K
A
M
T
D
L
N
Y
V
A
C
A
S
K
L
L
A
L
--
R
P
R
I
F
P
Q
F
A
T
H
N
A
L
T
V
A
T
V
L
E
M
A
E
G
-------
S
S
G
F
E
F
Q
R
L
H
G
M
G
E
A
L
Y
E
Q
L
A
K
-
D
H
AD
I
-
A
Y
R
T
Y
A
P
V
G
S
H
R
D
L
L
A
Y
L
V
R
R
L
L
E
N
G
A
N
S
S
F
V
A
Q
A
A
D
Y
R
V
P
V
P
A
L
L
Q
R
P
A
D
A
I
V
R
P
Q
A
A
A
H
P
R
I
P
L
P
C
D
L
F
A
P
E
R
R
N
S
R
G
V
E
F
G
A
R
T
---
A
L
D
Q
L
---------------------------
L
-
T
D
V
K
-
A
E
T
-
G
D
-
L
K
P
I
A
D
A
T
P
D
Q
A
H
A
A
V
A
A
A
R
A
G
F
A
G
W
S
R
T
P
A
G
I
R
A
A
A
L
E
Q
A
A
H
L
L
E
S
R
S
A
H
F
I
A
L
L
Q
R
E
G
G
K
T
L
D
D
A
L
S
E
L
R
E
A
A
D
F
C
R
Y
Y
A
A
Q
G
-
R
K
L
F
G
S
E
T
A
-
M
P
G
P
T
G
E
S
N
A
L
T
M
R
G
R
G
V
F
V
A
I
S
P
W
N
F
P
L
A
I
F
L
G
Q
V
T
A
A
L
M
A
G
N
S
V
V
A
K
P
A
E
Q
T
P
R
I
A
R
E
A
V
A
L
L
H
E
A
G
I
P
K
S
A
L
Y
L
V
T
G
D
G
-
R
I
G
A
A
L
T
A
H
P
D
I
A
G
V
V
F
T
G
S
T
E
V
-
A
-
R
S
I
N
R
---
A
L
A
A
K
D
G
P
--
I
V
P
L
I
A
E
T
G
G
I
N
A
M
I
A
D
A
T
A
L
P
E
Q
V
A
D
D
V
V
T
S
A
F
R
S
A
G
Q
R
C
S
A
L
R
L
L
F
V
Q
E
D
V
A
D
R
M
I
E
M
V
A
G
A
A
R
E
L
K
I
G
-
D
P
S
D
V
A
T
H
V
G
P
V
I
D
V
E
A
K
Q
R
L
D
A
H
I
A
R
M
K
T
E
A
R
L
H
F
A
G
P
-
A
---
P
E
G
C
F
V
A
P
H
I
F
-
E
L
T
E
A
G
Q
----
L
T
E
E
V
-
F
G
P
I
L
H
V
V
R
Y
R
P
E
N
L
E
R
V
L
R
A
I
E
R
T
G
Y
G
L
T
L
G
V
H
S
R
I
D
D
S
I
E
A
I
I
D
R
V
Q
V
G
N
I
Y
V
N
R
N
M
I
G
A
V
V
G
V
Q
P
F
G
G
N
G
L
S
G
T
G
P
K
A
G
G
P
H
Y
L
A
R
F
A
T
E
Q
T
V
T
I
N
T
A
A
A
G
------------
1
PsiBlast_PDB
94.83
49%
-86
- C3 -
3HAZ
13
?
A:
[8-987]
---------------------
P
P
F
T
A
P
Y
A
P
D
D
A
E
I
A
A
R
L
L
P
A
S
H
L
S
P
P
Q
E
A
R
I
H
R
T
A
T
R
L
I
E
A
I
R
K
R
--
R
L
G
G
V
E
D
M
L
R
E
F
A
L
S
T
K
E
G
L
A
L
M
V
L
A
E
A
L
L
R
V
P
D
A
R
T
A
D
Q
F
I
E
D
K
L
G
E
G
D
F
I
H
H
E
T
K
S
T
A
F
L
V
N
A
S
A
W
A
----
A
R
V
I
Q
P
G
E
T
P
D
G
----
T
I
G
R
L
V
K
R
L
G
A
P
A
V
R
T
A
T
R
Q
A
M
R
L
M
G
N
H
F
V
L
G
E
T
I
E
Q
A
L
E
R
G
-
K
P
R
S
G
Q
K
T
R
Y
S
F
D
M
L
G
E
G
A
R
T
A
A
D
A
R
R
Y
F
D
A
Y
A
S
A
I
E
T
I
G
K
A
A
G
-
N
H
A
L
P
D
R
P
G
I
S
V
K
L
S
A
L
H
P
R
F
E
A
I
S
R
A
R
V
M
V
E
L
V
P
Q
L
L
D
L
A
Q
R
A
K
A
H
D
L
N
F
T
V
D
A
E
E
A
D
R
L
E
L
S
L
D
V
I
A
A
T
L
A
D
P
S
L
K
G
W
D
G
F
G
L
A
I
Q
A
Y
Q
K
R
A
S
A
V
I
D
Y
V
D
A
L
A
R
A
H
D
R
K
L
M
V
R
L
V
K
G
A
Y
W
D
T
E
I
K
R
A
Q
E
R
G
L
D
G
Y
P
V
F
T
R
K
A
M
T
D
L
N
Y
V
A
C
A
S
K
L
L
A
L
R
P
R
--
I
F
P
Q
F
A
T
H
N
A
L
T
V
A
T
V
L
E
M
A
E
G
S
S
G
-------
F
E
F
Q
R
L
H
G
M
G
E
A
L
Y
E
Q
L
A
K
D
H
A
--
D
I
A
Y
R
T
Y
A
P
V
G
S
H
R
D
L
L
A
Y
L
V
R
R
L
L
E
N
G
A
N
S
S
F
V
A
Q
A
A
D
Y
R
V
P
V
P
A
L
L
Q
R
P
A
D
A
I
V
R
P
Q
A
A
A
H
P
R
I
P
L
P
C
D
L
F
A
P
E
R
R
N
S
R
G
V
E
F
G
A
R
T
A
L
D
Q
L
L
T
D
V
K
---
A
E
T
G
--
D
L
K
P
-
I
A
D
----------------------------
A
T
P
D
Q
A
H
A
A
V
A
A
A
R
A
G
F
A
G
W
S
R
T
P
A
G
I
R
A
A
A
L
E
Q
A
A
H
L
L
E
S
R
S
A
H
F
I
A
L
L
Q
R
E
G
G
K
T
L
D
D
A
L
S
E
L
R
E
A
A
D
F
C
R
Y
Y
A
A
Q
G
-
R
K
L
F
G
-
S
E
T
A
M
P
G
P
T
G
E
S
N
A
L
T
M
R
G
R
G
V
F
V
A
I
S
P
W
N
F
P
L
A
I
F
L
G
Q
V
T
A
A
L
M
A
G
N
S
V
V
A
K
P
A
E
Q
T
P
R
I
A
R
E
A
V
A
L
L
H
E
A
G
I
P
K
S
A
L
Y
L
V
T
G
D
G
-
R
I
G
A
A
L
T
A
H
P
D
I
A
G
V
V
F
T
G
S
T
E
V
-
A
-
R
S
I
N
R
---
A
L
A
A
K
D
G
P
--
I
V
P
L
I
A
E
T
G
G
I
N
A
M
I
A
D
A
T
A
L
P
E
Q
V
A
D
D
V
V
T
S
A
F
R
S
A
G
Q
R
C
S
A
L
R
L
L
F
V
Q
E
D
V
A
D
R
M
I
E
M
V
A
G
A
A
R
E
L
K
I
G
D
P
S
D
V
-
A
T
H
V
G
P
V
I
D
V
E
A
K
Q
R
L
D
A
H
I
A
R
M
K
T
E
A
R
L
H
F
A
G
P
-
A
P
---
E
G
C
F
V
A
P
H
I
F
-
E
L
T
E
A
G
Q
----
L
T
E
E
V
-
F
G
P
I
L
H
V
V
R
Y
R
P
E
N
L
E
R
V
L
R
A
I
E
R
T
G
Y
G
L
T
L
G
V
H
S
R
I
D
D
S
I
E
A
I
I
D
R
V
Q
V
G
N
I
Y
V
N
R
N
M
I
G
A
V
V
G
V
Q
P
F
G
G
N
G
L
S
G
T
G
P
K
A
G
G
P
H
Y
L
A
R
F
A
T
E
Q
T
V
T
I
N
T
A
A
A
G
------------
9
PsiBlast_PDB
63.46
34%
-78
- C3 -
3QAN
-
ROCA1_BACHD
A:
[41-513]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
N
G
E
R
V
T
T
E
D
K
I
Q
S
W
N
-
P
A
R
K
D
Q
L
V
G
S
V
S
K
A
N
Q
D
L
A
E
K
A
I
Q
S
A
D
E
A
F
Q
T
W
R
N
V
N
P
E
E
R
A
N
I
L
V
K
A
A
A
I
I
R
R
R
K
H
E
F
S
A
W
L
V
H
E
A
G
K
P
W
K
E
A
D
A
D
T
A
E
A
I
D
F
L
E
Y
Y
A
R
Q
M
-
I
E
L
N
R
-
G
K
E
-
I
L
S
R
P
G
E
Q
N
R
Y
F
Y
T
P
M
G
V
T
V
T
I
S
P
W
N
F
A
L
A
I
M
V
G
T
A
V
A
P
I
V
T
G
N
T
V
V
L
K
P
A
S
T
T
P
V
V
A
A
K
F
V
E
V
L
E
D
A
G
L
P
K
G
V
I
N
Y
V
P
G
S
G
A
E
V
G
D
Y
L
V
D
H
P
K
T
S
L
I
T
F
T
G
S
K
D
V
-
G
V
R
L
Y
E
R
---
A
A
V
V
R
P
G
Q
N
H
L
K
R
V
I
V
E
M
G
G
K
D
T
V
V
V
D
R
D
A
D
L
D
L
A
A
E
S
I
L
V
S
A
F
G
F
S
G
Q
K
C
S
A
G
S
R
A
V
I
H
K
D
V
Y
D
E
V
L
E
K
T
V
A
L
A
K
N
L
T
V
G
-
D
P
T
N
R
D
N
Y
M
G
P
V
I
D
E
K
A
F
E
K
I
M
S
Y
I
E
I
G
K
K
E
G
R
L
M
T
G
G
E
-
G
D
S
S
-
T
G
F
F
I
Q
P
T
I
---
I
A
D
L
D
P
EAVI
M
Q
E
E
I
-
F
G
P
V
V
A
F
S
K
--
A
N
D
F
D
H
A
L
E
I
A
N
N
T
E
Y
G
L
T
G
A
V
I
T
R
N
R
A
H
I
E
Q
A
K
R
E
F
H
V
G
N
L
Y
F
N
R
N
C
T
G
A
I
V
G
Y
H
P
F
G
G
F
K
M
S
G
T
D
S
K
A
G
G
P
D
Y
L
A
L
H
M
Q
A
K
T
V
S
E
M
Y
----------------
21
PsiBlast_CBE
63.05
34%
-80
- C3 -
3QAN
1
ROCA1_BACHD
C:
[41-513]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
N
G
E
R
V
T
T
E
D
K
I
Q
S
W
N
-
P
A
R
K
D
Q
L
V
G
S
V
S
K
A
N
Q
D
L
A
E
K
A
I
Q
S
A
D
E
A
F
Q
T
W
R
N
V
N
P
E
E
R
A
N
I
L
V
K
A
A
A
I
I
R
R
R
K
H
E
F
S
A
W
L
V
H
E
A
G
K
P
W
K
E
A
D
A
D
T
A
E
A
I
D
F
L
E
Y
Y
A
R
Q
M
-
I
E
L
N
R
-
G
K
E
-
I
L
S
R
P
G
E
Q
N
R
Y
F
Y
T
P
M
G
V
T
V
T
I
S
P
W
N
F
A
L
A
I
M
V
G
T
A
V
A
P
I
V
T
G
N
T
V
V
L
K
P
A
S
T
T
P
V
V
A
A
K
F
V
E
V
L
E
D
A
G
L
P
K
G
V
I
N
Y
V
P
G
S
G
A
E
V
G
D
Y
L
V
D
H
P
K
T
S
L
I
T
F
T
G
S
K
D
V
-
G
V
R
L
Y
E
R
---
A
A
V
V
R
P
G
Q
NH
L
K
R
V
I
V
E
M
G
G
K
D
T
V
V
V
D
R
D
A
D
L
D
L
A
A
E
S
I
L
V
S
A
F
G
F
S
G
Q
K
C
S
A
G
S
R
A
V
I
H
K
D
V
Y
D
E
V
L
E
K
T
V
A
L
A
K
N
L
T
V
G
-
D
P
T
N
R
D
N
Y
M
G
P
V
I
D
E
K
A
F
E
K
I
M
S
Y
I
E
I
G
K
K
E
G
R
L
M
T
G
G
E
-
G
D
S
S
-
T
G
F
F
I
Q
P
T
I
---
I
A
D
L
D
P
EAVI
M
Q
E
E
I
-
F
G
P
V
V
A
F
S
K
--
A
N
D
F
D
H
A
L
E
I
A
N
N
T
E
Y
G
L
T
G
A
V
I
T
R
N
R
A
H
I
E
Q
A
K
R
E
F
H
V
G
N
L
Y
F
N
R
N
C
T
G
A
I
V
G
Y
H
P
F
G
G
F
K
M
S
G
T
D
S
K
A
G
G
P
D
Y
L
A
L
H
M
Q
A
K
T
V
S
E
M
Y
A
---------------
22
PsiBlast_CBE
62.95
32%
-75
- C3 -
3RJL
10
ROCA_BACLD
H:
[6-513]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
E
P
F
T
N
F
G
I
E
E
N
R
K
A
F
E
K
A
L
E
T
-
V
N
N
E
W
LG
Q
S
Y
P
L
V
I
D
G
E
R
Y
E
T
E
N
K
-
I
V
S
I
N
P
A
N
K
E
E
V
V
G
T
V
S
K
A
T
Q
D
H
A
E
K
A
I
Q
A
A
A
K
A
F
E
T
W
R
Y
T
D
P
E
E
R
A
A
V
L
F
R
A
V
A
K
V
R
R
K
K
H
E
F
S
A
L
L
V
K
E
A
G
K
P
W
N
E
A
D
A
D
T
A
E
A
I
D
F
M
E
Y
Y
A
R
Q
M
-
I
E
L
A
K
-
G
K
P
-
V
N
S
R
E
G
E
R
N
Q
Y
V
Y
T
P
T
G
V
T
V
V
I
P
P
W
N
F
L
F
A
I
M
A
G
T
T
V
A
P
I
V
T
G
N
T
V
V
L
K
P
A
S
A
A
P
V
I
A
A
K
F
V
E
V
L
E
E
S
G
L
P
K
G
V
V
N
F
V
P
G
S
G
A
E
V
G
D
Y
L
V
D
H
P
K
T
S
I
I
T
F
T
G
S
R
E
V
G
T
-
R
I
F
E
R
---
A
A
K
V
Q
P
G
Q
TH
L
K
Q
V
I
A
E
M
G
G
K
D
T
V
V
V
D
E
D
C
D
I
E
L
A
A
Q
S
I
F
T
S
A
F
G
F
A
G
Q
K
C
S
A
G
S
R
A
V
V
H
E
K
V
Y
D
E
V
L
K
R
V
I
E
I
T
E
S
K
K
V
G
-
E
P
D
S
A
D
V
Y
M
G
P
V
I
D
Q
A
S
F
N
K
I
M
D
Y
I
E
I
G
K
E
E
G
R
L
V
S
G
G
K
--
G
D
D
S
K
G
Y
F
I
E
P
T
I
F
---
A
D
L
D
P
KARL
M
Q
E
E
I
-
F
G
P
V
V
A
F
S
K
V
S
S
F
D
--
E
A
L
E
V
A
N
N
T
E
Y
G
L
T
G
A
V
I
T
K
N
R
D
H
I
N
R
A
K
Q
E
F
H
V
G
N
L
Y
F
N
R
N
C
T
G
A
I
V
G
Y
H
P
F
G
G
F
K
M
S
G
T
D
S
K
A
G
G
P
D
Y
L
A
L
H
M
Q
A
K
T
I
S
E
M
F
----------------
26
PsiBlast_CBE
62.47
32%
-74
- C3 -
3RJL
2
ROCA_BACLD
D:
[6-513]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
E
P
F
T
N
F
G
I
E
E
N
R
K
A
F
E
K
A
L
E
T
-
V
N
N
E
W
LG
Q
S
Y
P
L
V
I
D
G
E
R
Y
E
T
E
N
K
-
I
V
S
I
N
P
A
N
K
E
E
V
V
G
T
V
S
K
A
T
Q
D
H
A
E
K
A
I
Q
A
A
A
K
A
F
E
T
W
R
Y
T
D
P
E
E
R
A
A
V
L
F
R
A
V
A
K
V
R
R
K
K
H
E
F
S
A
L
L
V
K
E
A
G
K
P
W
N
E
A
D
A
D
T
A
E
A
I
D
F
M
E
Y
Y
A
R
Q
M
-
I
E
L
A
K
-
G
K
P
-
V
N
S
R
E
G
E
R
N
Q
Y
V
Y
T
P
T
G
V
T
V
V
I
P
P
W
N
F
L
F
A
I
M
A
G
T
T
V
A
P
I
V
T
G
N
T
V
V
L
K
P
A
S
A
A
P
V
I
A
A
K
F
V
E
V
L
E
E
S
G
L
P
K
G
V
V
N
F
V
P
G
S
G
A
E
V
G
D
Y
L
V
D
H
P
K
T
S
I
I
T
F
T
G
S
R
E
V
G
T
-
R
I
F
E
R
---
A
A
K
V
Q
P
G
Q
TH
L
K
Q
V
I
A
E
M
G
G
K
D
T
V
V
V
D
E
D
C
D
I
E
L
A
A
Q
S
I
F
T
S
A
F
G
F
A
G
Q
K
C
S
A
G
S
R
A
V
V
H
E
K
V
Y
D
E
V
L
K
R
V
I
E
I
T
E
S
K
K
V
G
-
E
P
D
S
A
D
V
Y
M
G
P
V
I
D
Q
A
S
F
N
K
I
M
D
Y
I
E
I
G
K
E
E
G
R
L
V
S
G
G
K
--
G
D
D
S
K
G
Y
F
I
E
P
T
I
F
---
A
D
L
D
P
KARL
M
Q
E
E
I
-
F
G
P
V
V
A
F
S
K
V
S
S
F
D
--
E
A
L
E
V
A
N
N
T
E
Y
G
L
T
G
A
V
I
T
K
N
R
D
H
I
N
R
A
K
Q
E
F
H
V
G
N
L
Y
F
N
R
N
C
T
G
A
I
V
G
Y
H
P
F
G
G
F
K
M
S
G
T
D
S
K
A
G
G
P
D
Y
L
A
L
H
M
Q
A
K
T
I
S
E
M
F
----------------
27
PsiBlast_CBE
62.22
32%
-73
- C3 -
3RJL
3
ROCA_BACLD
C:
[6-513]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
E
P
F
T
N
F
G
I
E
E
N
R
K
A
F
E
K
A
L
E
T
-
V
N
N
E
W
LG
Q
S
Y
P
L
V
I
D
G
E
R
Y
E
T
E
N
K
-
I
V
S
I
N
P
A
N
K
E
E
V
V
G
T
V
S
K
A
T
Q
D
H
A
E
K
A
I
Q
A
A
A
K
A
F
E
T
W
R
Y
T
D
P
E
E
R
A
A
V
L
F
R
A
V
A
K
V
R
R
K
K
H
E
F
S
A
L
L
V
K
E
A
G
K
P
W
N
E
A
D
A
D
T
A
E
A
I
D
F
M
E
Y
Y
A
R
Q
M
-
I
E
L
A
K
-
G
K
P
-
V
N
S
R
E
G
E
R
N
Q
Y
V
Y
T
P
T
G
V
T
V
V
I
P
P
W
N
F
L
F
A
I
M
A
G
T
T
V
A
P
I
V
T
G
N
T
V
V
L
K
P
A
S
A
A
P
V
I
A
A
K
F
V
E
V
L
E
E
S
G
L
P
K
G
V
V
N
F
V
P
G
S
G
A
E
V
G
D
Y
L
V
D
H
P
K
T
S
I
I
T
F
T
G
S
R
E
V
G
T
-
R
I
F
E
R
---
A
A
K
V
Q
P
G
Q
TH
L
K
Q
V
I
A
E
M
G
G
K
D
T
V
V
V
D
E
D
C
D
I
E
L
A
A
Q
S
I
F
T
S
A
F
G
F
A
G
Q
K
C
S
A
G
S
R
A
V
V
H
E
K
V
Y
D
E
V
L
K
R
V
I
E
I
T
E
S
K
K
V
G
-
E
P
D
S
A
D
V
Y
M
G
P
V
I
D
Q
A
S
F
N
K
I
M
D
Y
I
E
I
G
K
E
E
G
R
L
V
S
G
G
K
--
G
D
D
S
K
G
Y
F
I
E
P
T
I
F
---
A
D
L
D
P
KARL
M
Q
E
E
I
-
F
G
P
V
V
A
F
S
K
V
S
S
F
D
--
E
A
L
E
V
A
N
N
T
E
Y
G
L
T
G
A
V
I
T
K
N
R
D
H
I
N
R
A
K
Q
E
F
H
V
G
N
L
Y
F
N
R
N
C
T
G
A
I
V
G
Y
H
P
F
G
G
F
K
M
S
G
T
D
S
K
A
G
G
P
D
Y
L
A
L
H
M
Q
A
K
T
I
S
E
M
F
----------------
28
PsiBlast_CBE
61.84
32%
-75
- C3 -
3RJL
8
ROCA_BACLD
B:
[6-513]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
E
P
F
T
N
F
G
I
E
E
N
R
K
A
F
E
K
A
L
E
T
-
V
N
N
E
W
LG
Q
S
Y
P
L
V
I
D
G
E
R
Y
E
T
E
N
K
-
I
V
S
I
N
P
A
N
K
E
E
V
V
G
T
V
S
K
A
T
Q
D
H
A
E
K
A
I
Q
A
A
A
K
A
F
E
T
W
R
Y
T
D
P
E
E
R
A
A
V
L
F
R
A
V
A
K
V
R
R
K
K
H
E
F
S
A
L
L
V
K
E
A
G
K
P
W
N
E
A
D
A
D
T
A
E
A
I
D
F
M
E
Y
Y
A
R
Q
M
-
I
E
L
A
K
-
G
K
P
-
V
N
S
R
E
G
E
R
N
Q
Y
V
Y
T
P
T
G
V
T
V
V
I
P
P
W
N
F
L
F
A
I
M
A
G
T
T
V
A
P
I
V
T
G
N
T
V
V
L
K
P
A
S
A
A
P
V
I
A
A
K
F
V
E
V
L
E
E
S
G
L
P
K
G
V
V
N
F
V
P
G
S
G
A
E
V
G
D
Y
L
V
D
H
P
K
T
S
I
I
T
F
T
G
S
R
E
V
G
T
-
R
I
F
E
R
---
A
A
K
V
Q
P
G
Q
T
H
L
K
Q
V
I
A
E
M
G
G
K
D
T
V
V
V
D
E
D
C
D
I
E
L
A
A
Q
S
I
F
T
S
A
F
G
F
A
G
Q
K
C
S
A
G
S
R
A
V
V
H
E
K
V
Y
D
E
V
L
K
R
V
I
E
I
T
E
S
K
K
V
G
-
E
P
D
S
A
D
V
Y
M
G
P
V
I
D
Q
A
S
F
N
K
I
M
D
Y
I
E
I
G
K
E
E
G
R
L
V
S
G
G
K
--
G
D
D
S
K
G
Y
F
I
E
P
T
I
F
---
A
D
L
D
P
KARL
M
Q
E
E
I
-
F
G
P
V
V
A
F
S
K
V
S
S
F
D
--
E
A
L
E
V
A
N
N
T
E
Y
G
L
T
G
A
V
I
T
K
N
R
D
H
I
N
R
A
K
Q
E
F
H
V
G
N
L
Y
F
N
R
N
C
T
G
A
I
V
G
Y
H
P
F
G
G
F
K
M
S
G
T
D
S
K
A
G
G
P
D
Y
L
A
L
H
M
Q
A
K
T
I
S
E
M
F
----------------
10
PsiBlast_PDB
61.37
32%
-73
- C3 -
3RJL
10
ROCA_BACLD
A:
[6-513]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
E
P
F
T
N
F
G
I
E
E
N
R
K
A
F
E
K
A
L
E
T
-
V
N
N
E
W
LG
Q
S
Y
P
L
V
I
D
G
E
R
Y
E
T
E
N
K
-
I
V
S
I
N
P
A
N
K
E
E
V
V
G
T
V
S
K
A
T
Q
D
H
A
E
K
A
I
Q
A
A
A
K
A
F
E
T
W
R
Y
T
D
P
E
E
R
A
A
V
L
F
R
A
V
A
K
V
R
R
K
K
H
E
F
S
A
L
L
V
K
E
A
G
K
P
W
N
E
A
D
A
D
T
A
E
A
I
D
F
M
E
Y
Y
A
R
Q
M
-
I
E
L
A
K
-
G
K
P
-
V
N
S
R
E
G
E
R
N
Q
Y
V
Y
T
P
T
G
V
T
V
V
I
P
P
W
N
F
L
F
A
I
M
A
G
T
T
V
A
P
I
V
T
G
N
T
V
V
L
K
P
A
S
A
A
P
V
I
A
A
K
F
V
E
V
L
E
E
S
G
L
P
K
G
V
V
N
F
V
P
G
S
G
A
E
V
G
D
Y
L
V
D
H
P
K
T
S
I
I
T
F
T
G
S
R
E
V
G
T
-
R
I
F
E
R
---
A
A
K
V
Q
P
G
Q
T
H
L
K
Q
V
I
A
E
M
G
G
K
D
T
V
V
V
D
E
D
C
D
I
E
L
A
A
Q
S
I
F
T
S
A
F
G
F
A
G
Q
K
C
S
A
G
S
R
A
V
V
H
E
K
V
Y
D
E
V
L
K
R
V
I
E
I
T
E
S
K
K
V
G
-
E
P
D
S
A
D
V
Y
M
G
P
V
I
D
Q
A
S
F
N
K
I
M
D
Y
I
E
I
G
K
E
E
G
R
L
V
S
G
G
K
--
G
D
D
S
K
G
Y
F
I
E
P
T
I
F
---
A
D
L
D
P
KARL
M
Q
E
E
I
-
F
G
P
V
V
A
F
S
K
V
S
S
F
D
--
E
A
L
E
V
A
N
N
T
E
Y
G
L
T
G
A
V
I
T
K
N
R
D
H
I
N
R
A
K
Q
E
F
H
V
G
N
L
Y
F
N
R
N
C
T
G
A
I
V
G
Y
H
P
F
G
G
F
K
M
S
G
T
D
S
K
A
G
G
P
D
Y
L
A
L
H
M
Q
A
K
T
I
S
E
M
F
----------------
17
PsiBlast_PDB
61.21
37%
-77
- C3 -
2EJ6
11
?
A:
[90-513]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
R
Y
P
-
A
V
E
-
V
V
P
Y
P
G
E
D
N
E
S
F
Y
V
P
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
-
G
-
L
K
I
Y
E
A
A
G
R
L
A
P
G
Q
T
W
--
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
-
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
L
V
L
G
G
K
R
L
E
G
--
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
----
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
----------------
19
PsiBlast_PDB
61.12
37%
-77
- C3 -
2J5N
12
?
A:
[90-513]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
R
Y
P
-
A
V
E
-
V
V
P
Y
P
G
E
D
N
E
S
F
Y
V
P
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
-
G
-
L
K
I
Y
E
A
A
G
R
L
A
P
G
Q
T
W
--
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
-
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
L
V
L
G
G
K
R
L
E
G
--
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
----
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
----------------
16
PsiBlast_PDB
60.97
37%
-76
- C3 -
2EHQ
10
?
A:
[90-513]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
R
Y
P
-
A
V
E
-
V
V
P
Y
P
G
E
D
N
E
S
F
Y
V
P
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
-
G
-
L
K
I
Y
E
A
A
G
R
L
A
P
G
Q
T
W
--
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
-
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
L
V
L
G
G
K
R
L
E
G
--
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
----
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
----------------
34
PsiBlast_CBE
60.85
37%
-76
- C3 -
2EIT
13
?
B:
[90-513]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
R
Y
P
-
A
V
E
-
V
V
P
Y
P
G
E
D
N
E
S
F
Y
V
P
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
-
G
-
L
K
I
Y
E
AAG
R
L
A
P
G
Q
T
W
--
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
-
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
L
V
L
G
G
K
R
L
E
G
--
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
----
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
----------------
33
PsiBlast_CBE
60.63
37%
-76
- C3 -
2EJ6
12
?
B:
[90-513]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
R
Y
P
-
A
V
E
-
V
V
P
Y
P
G
E
D
N
E
S
F
Y
V
P
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
-
G
-
L
K
I
Y
E
AAG
R
L
A
P
G
Q
T
W
--
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
-
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
L
V
L
G
G
K
R
L
E
G
--
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
----
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
----------------
13
PsiBlast_PDB
60.57
37%
-75
- C3 -
2BHP
14
?
A:
[90-513]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
R
Y
P
-
A
V
E
-
V
V
P
Y
P
G
E
D
N
E
S
F
Y
V
P
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
-
G
-
L
K
I
Y
E
A
A
G
R
L
A
P
G
Q
T
W
--
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
-
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
L
V
L
G
G
K
R
L
E
G
--
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
----
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
----------------
15
PsiBlast_PDB
60.46
37%
-77
- C3 -
2IY6
12
?
A:
[90-513]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
R
Y
P
-
A
V
E
-
V
V
P
Y
P
G
E
D
N
E
S
F
Y
V
P
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
-
G
-
L
K
I
Y
E
A
A
G
R
L
A
P
G
Q
T
W
--
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
-
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
L
V
L
G
G
K
R
L
E
G
--
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
----
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
----------------
36
PsiBlast_CBE
60.39
37%
-75
- C3 -
2EII
15
?
A:
[90-513]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
R
Y
P
-
A
V
E
-
V
V
P
Y
P
G
E
D
N
E
S
F
Y
V
P
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
-
G
-
L
K
I
Y
E
A
A
G
R
L
A
P
G
Q
T
W
--
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
-
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
L
V
L
G
G
K
R
L
E
G
--
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
----
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
----------------
39
PsiBlast_CBE
60.36
37%
-77
- C3 -
2EHQ
10
?
B:
[90-513]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
R
Y
P
-
A
V
E
-
V
V
P
Y
P
G
E
D
N
E
S
F
Y
V
P
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
-
G
-
L
K
I
Y
E
AAG
R
L
A
P
G
Q
T
W
--
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
-
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
L
V
L
G
G
K
R
L
E
G
--
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
----
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
----------------
30
PsiBlast_CBE
60.36
37%
-75
- C3 -
1UZB
6
?
B:
[90-513]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
R
Y
P
-
A
V
E
-
V
V
P
Y
P
G
E
D
N
E
S
F
Y
V
P
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
-
G
-
L
K
I
Y
E
AAG
R
L
A
P
G
Q
T
W
--
F
K
R
A
Y
V
E
T
G
G
K
N
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
-
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
L
V
L
G
G
K
R
L
E
G
--
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
----
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
----------------
32
PsiBlast_CBE
60.16
37%
-77
- C3 -
2IY6
13
?
B:
[90-513]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
R
Y
P
-
A
V
E
-
V
V
P
Y
P
G
E
D
N
E
S
F
Y
V
P
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
-
G
-
L
K
I
Y
E
AAG
R
L
A
P
G
Q
T
W
--
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
-
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
L
V
L
G
G
K
R
L
E
G
--
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
----
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
----------------
20
PsiBlast_PDB
60.16
37%
-76
- C3 -
2EIT
12
?
A:
[90-513]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
R
Y
P
-
A
V
E
-
V
V
P
Y
P
G
E
D
N
E
S
F
Y
V
P
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
-
G
-
L
K
I
Y
E
A
A
G
R
L
A
P
G
Q
T
W
--
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
-
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
L
V
L
G
G
K
R
L
E
G
--
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
----
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
----------------
18
PsiBlast_PDB
60.11
37%
-76
- C3 -
2BHQ
11
?
A:
[90-513]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
R
Y
P
-
A
V
E
-
V
V
P
Y
P
G
E
D
N
E
S
F
Y
V
P
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
-
G
-
L
K
I
Y
E
A
A
G
R
L
A
P
G
Q
T
W
--
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
-
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
L
V
L
G
G
K
R
L
E
G
--
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
----
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
----------------
38
PsiBlast_CBE
60.07
37%
-75
- C3 -
2EHU
15
?
A:
[90-513]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
R
Y
P
-
A
V
E
-
V
V
P
Y
P
G
E
D
N
E
S
F
Y
V
P
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
-
G
-
L
K
I
Y
E
A
A
G
R
L
A
P
G
Q
T
W
--
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
-
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
L
V
L
G
G
K
R
L
E
G
--
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
----
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
----------------
29
PsiBlast_CBE
60.03
37%
-76
- C3 -
2EIW
10
?
B:
[90-513]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
R
Y
P
-
A
V
E
-
V
V
P
Y
P
G
E
D
N
E
S
F
Y
V
P
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
-
G
-
L
K
I
Y
E
AAG
R
L
A
P
G
Q
T
W
--
F
K
R
A
Y
V
E
T
G
G
K
N
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
-
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
L
V
L
G
G
K
R
L
E
G
--
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
----
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
----------------
42
PsiBlast_CBE
60.01
37%
-74
- C3 -
2BHP
11
?
B:
[90-513]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
R
Y
P
-
A
V
E
-
V
V
P
Y
P
G
E
D
N
E
S
F
Y
V
P
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
-
G
-
L
K
I
Y
E
AAG
R
L
A
P
G
Q
T
W
--
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
-
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
L
V
L
G
G
K
R
L
E
G
--
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
----
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
----------------
35
PsiBlast_CBE
59.97
37%
-75
- C3 -
2EII
17
?
B:
[90-513]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
R
Y
P
-
A
V
E
-
V
V
P
Y
P
G
E
D
N
E
S
F
Y
V
P
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
-
G
-
L
K
I
Y
E
AAG
R
L
A
P
G
Q
T
W
--
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
-
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
L
V
L
G
G
K
R
L
E
G
--
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
----
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
----------------
31
PsiBlast_CBE
59.80
37%
-76
- C3 -
2J5N
13
?
B:
[90-513]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
R
Y
P
-
A
V
E
-
V
V
P
Y
P
G
E
D
N
E
S
F
Y
V
P
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
-
G
-
L
K
I
Y
E
AAG
R
L
A
P
G
Q
T
W
--
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
-
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
L
V
L
G
G
K
R
L
E
G
--
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
----
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
----------------
37
PsiBlast_CBE
59.77
37%
-76
- C3 -
2EHU
16
?
B:
[90-513]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
R
Y
P
-
A
V
E
-
V
V
P
Y
P
G
E
D
N
E
S
F
Y
V
P
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
-
G
-
L
K
I
Y
E
AAG
R
L
A
P
G
Q
T
W
--
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
-
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
L
V
L
G
G
K
R
L
E
G
--
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
----
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
----------------
14
PsiBlast_PDB
59.76
37%
-75
- C3 -
2BJK
10
?
A:
[90-513]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
R
Y
P
-
A
V
E
-
V
V
P
Y
P
G
E
D
N
E
S
F
Y
V
P
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
-
G
-
L
K
I
Y
E
A
A
G
R
L
A
P
G
Q
T
W
--
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
-
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
L
V
L
G
G
K
R
L
E
G
--
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
----
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
----------------
40
PsiBlast_CBE
59.62
37%
-75
- C3 -
2BJK
11
?
B:
[90-513]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
R
Y
P
-
A
V
E
-
V
V
P
Y
P
G
E
D
N
E
S
F
Y
V
P
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
-
G
-
L
K
I
Y
E
AAG
R
L
A
P
G
Q
T
W
--
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
-
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
L
V
L
G
G
K
R
L
E
G
--
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
----
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
----------------
41
PsiBlast_CBE
59.58
37%
-76
- C3 -
2BHQ
8
?
B:
[90-513]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
R
Y
P
-
A
V
E
-
V
V
P
Y
P
G
E
D
N
E
S
F
Y
V
P
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
-
G
-
L
K
I
Y
E
AAG
R
L
A
P
G
Q
T
W
--
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
-
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
L
V
L
G
G
K
R
L
E
G
--
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
----
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
----------------