@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0836: (2016-01-21 )
MPSRNILVINCGSSSIKFALVNEAHSLFPLHGLAERLGSRDAVLRWKRGGDSDSLMIPNADHRAALAQLLPMVQNAAGGKLHGIGHRVVHGGELFTHATRIDDRVVEAIRATAPLAPLHNPANLQGIEAAMTLFPKLPHVAVFDTAFHQSLPEHAYRYALPEALYREHGVRRYGFHGTSHRYVSHRAAEMAGLAVGDSSWLSAHLGNGSSTCAIVNGQSLDTSMGLTPLEGLVMGTRSGDVDPNLHSHLARTLGWSLERIDSMLNNESGLLGLSDLSNDMRTLEQEREQGHPGAALAIEVFCYRLAKSLAAMSCALPQLDGVIFTGGIGENSPLVRAKTAAHLRLFDLRLDQEANARCVRGVAGPIQAAGHPRVLVIPTNEERQIALDTLALLD
Atome Classification :
(32 SA)
.........10........20........30........40......-.-.50-........60.--.......-70-..---.------.-.-----.---.-----.------80........90........100.......110.......120.......130......--.140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270..-.-....280.......290.......300.......310.....-..320.......330.......340.......350.......---360.......-370-...--....380.......390..-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPSR
N
I
L
V
I
NCGSS
S
I
K
F
A
L
VNEAHSLF
P
L
H
G
L
A
E
R
LGSRD
A
V
L
R
WK-R-GGD-SD
S
L
MIPNA
D
H
--
R
A
A
L
A
Q
L
-
L
P
-
M
V
---
Q
------N-A-----A---G-----G------KLHGIGH
R
V
VHGG
E
L
F
T
H
A
TR
I
D
D
R
V
V
E
A
I
R
ATAPLAPLHNPAN
L
Q
G
I
E
A
A
M
T
LFPKLP--H
V
A
V
F
D
T
A
F
H
Q
S
L
P
E
H
A
Y
R
YA
L
P
E
A
L
Y
R
EHG
V
R
RYGFHGTS
H
R
Y
V
S
H
R
A
A
E
M
A
G
L
AVGD
S
S
W
L
S
A
HLGNGS
S
T
C
A
I
VNGQSLDTSMGLT
P
L
E
G
L
V
MGTRSGDVD
P
N
L
H
S
H
L
A
R
T
LG
W
S
L
E
R
I
D
S
M
LNNESGLL
G
L
S
-
D
-
L
S
N
D
M
R
T
L
E
Q
E
R
EQGHPG
A
A
L
A
I
E
V
F
C
Y
R
L
A
K
S
L
A
A
M
S
CALP-QLD
G
V
I
F
TGGIGENS
P
L
V
R
A
KT
A
A
H
L
R
L
F
D
L
RLDQEAN
A
R
C
V
---RGVAGPIQAA-GH
P
-
R
V
L
--
V
I
PTNEE
R
Q
I
A
L
D
T
L
ALLD-
48
HHSearch
96.86
44%
-94
* C2 *
2IIR
-
ACKA_THEMA
A:
[1-399]
---
M
R
V
L
V
I
N
S
G
S
S
S
I
K
Y
Q
L
I
E
M
E
G
E
K
V
L
C
K
G
I
A
E
R
I
G
I
E
G
S
R
L
V
H
R
-
V
-
G
D
E
-
K
H
V
I
E
R
E
L
P
D
H
--
E
E
A
L
K
L
I
-
L
N
-
T
L
---
V
------
D
E
K
LGVIK
D
---
L
-----
K
------
E
I
D
A
V
G
H
R
V
V
H
G
G
E
R
F
K
E
S
V
L
V
D
E
E
V
L
K
A
I
E
E
V
S
P
L
A
P
L
H
N
P
A
N
L
M
G
I
K
A
A
M
K
L
L
P
G
V
P
--
N
V
A
V
F
D
T
A
F
H
Q
T
I
P
Q
K
A
Y
L
Y
A
I
P
Y
E
Y
Y
E
K
Y
K
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
K
R
A
A
E
I
L
G
K
K
L
E
E
L
K
I
I
T
C
H
I
G
N
G
A
S
V
A
A
V
K
Y
G
K
C
V
D
T
S
M
G
F
T
P
L
E
G
L
V
M
G
T
R
S
G
D
L
D
P
A
I
P
F
F
I
M
E
K
E
G
I
S
P
Q
E
M
Y
D
I
L
N
K
K
S
G
V
Y
G
L
S
K
G
-
F
S
S
D
M
R
D
I
E
E
A
A
L
K
G
D
E
W
C
K
L
V
L
E
I
Y
D
Y
R
I
A
K
Y
I
G
A
Y
A
A
A
M
N
-
G
V
D
A
I
V
F
T
A
G
V
G
E
N
S
P
I
T
R
E
D
V
C
S
Y
L
E
F
L
G
V
K
L
D
K
Q
K
N
E
E
T
I
---
R
G
K
E
G
I
I
S
T
P
-
D
S
R
V
K
V
L
--
V
V
P
T
N
E
E
L
M
I
A
R
D
T
K
E
I
V
E
-
1
PsiBlast_PDB
96.36
43%
-95
- C2 -
2IIR
-
ACKA_THEMA
A:
[3-399]
-----
V
L
V
I
N
S
G
S
S
S
I
K
Y
Q
L
I
E
M
E
G
E
K
V
L
C
K
G
I
A
E
R
I
G
I
E
G
S
R
L
V
H
R
-
V
-
G
D
E
-
K
H
V
I
E
R
E
L
P
D
H
--
E
E
A
L
K
L
I
-
L
N
-
T
L
---
V
------
D
-
E
-----
K
---
L
-----
G
VIKDLK
E
I
D
A
V
G
H
R
V
V
H
G
G
E
R
F
K
E
S
V
L
V
D
E
E
V
L
K
A
I
E
E
V
S
P
L
A
P
L
H
N
P
A
N
L
M
G
I
K
A
A
M
K
L
L
P
G
V
P
--
N
V
A
V
F
D
T
A
F
H
Q
T
I
P
Q
K
A
Y
L
Y
A
I
P
Y
E
Y
Y
E
K
Y
K
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
K
R
A
A
E
I
L
G
K
K
L
E
E
L
K
I
I
T
C
H
I
G
N
G
A
S
V
A
A
V
K
Y
G
K
C
V
D
T
S
M
G
F
T
P
L
E
G
L
V
M
G
T
R
S
G
D
L
D
P
A
I
P
F
F
I
M
E
K
E
G
I
S
P
Q
E
M
Y
D
I
L
N
K
K
S
G
V
Y
G
L
S
-
K
G
F
S
S
D
M
R
D
I
E
E
A
A
L
K
G
D
E
W
C
K
L
V
L
E
I
Y
D
Y
R
I
A
K
Y
I
G
A
Y
A
A
A
M
N
-
G
V
D
A
I
V
F
T
A
G
V
G
E
N
S
P
I
T
R
E
D
V
C
S
Y
L
E
F
L
G
V
K
L
D
K
Q
K
N
E
E
T
I
---
R
G
K
E
G
I
I
S
T
P
D
S
R
V
-
K
V
L
--
V
V
P
T
N
E
E
L
M
I
A
R
D
T
K
E
I
V
E
-
14
PsiBlast_PDB
95.47
48%
-97
- C2 -
4FWP
3
TDCD_SALTY
A:
[20-405]
-----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
----
G
D
-
K
-
P
I
N
L
A
H
S
N
Y
--
E
D
A
L
K
A
I
A
F
E
-
L
E
---
K
------
R
-
D
-----
L
---
T
-----
D
------
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
--
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
-
L
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
-
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
----
N
S
H
G
E
R
I
I
S
A
-
N
P
S
-
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
-
21
PsiBlast_CBE
95.46
46%
-90
- C2 -
3SLC
1
ACKA_SALTY
D:
[18-409]
--
S
K
L
V
L
V
L
N
C
G
S
S
S
L
K
F
A
I
I
D
A
V
N
G
D
E
Y
L
S
G
L
A
E
C
F
H
L
P
E
A
R
I
K
W
K
-
M
D
G
S
K
-
Q
E
A
A
L
G
A
G
A
A
H
--
S
E
A
L
N
F
I
-
V
N
-
T
I
LAQ
K
------
P
-
E
-----
L
---
S
-----
A
------
Q
L
T
A
I
G
H
R
I
V
H
G
G
E
K
Y
T
S
S
V
V
I
D
E
S
V
I
Q
G
I
K
D
S
A
S
F
A
P
L
H
N
P
A
H
L
I
G
I
A
E
A
L
K
S
F
P
Q
L
K
DK
N
V
A
V
F
D
T
A
F
H
Q
T
M
P
E
E
S
Y
L
Y
A
L
P
Y
S
L
Y
K
E
H
G
V
R
R
Y
G
A
H
G
T
S
H
F
Y
V
T
Q
E
A
A
K
M
L
N
K
P
V
E
E
L
N
I
I
T
C
H
L
G
N
G
G
S
V
S
A
I
R
N
G
K
C
V
D
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
I
D
P
A
I
I
F
H
L
H
D
T
L
G
M
S
V
D
Q
I
N
K
M
L
T
K
E
S
G
L
L
G
L
T
-
E
-
V
T
S
D
C
R
Y
V
E
-
D
N
Y
A
T
K
E
D
A
K
R
A
M
D
V
Y
C
H
R
L
A
K
Y
I
G
S
Y
T
A
L
M
D
G
R
L
D
A
V
V
F
T
G
G
I
G
E
N
A
A
M
V
R
E
L
S
L
G
K
L
G
V
L
G
F
E
V
D
H
E
R
N
L
A
A
R
---
F
G
K
S
G
F
I
N
K
E
-
G
T
R
-
P
A
V
--
V
I
P
T
N
E
E
L
V
I
A
Q
D
A
S
R
L
T
A
-
4
PsiBlast_PDB
95.38
48%
-93
- C2 -
4FWL
2
TDCD_SALTY
A:
[20-405]
-----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
----
G
D
-
K
-
P
I
N
---
S
N
Y
--
E
D
A
L
K
A
I
A
F
E
-
L
E
---
K
------
R
-
D
-----
L
---
T
-----
D
------
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
--
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
-
L
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
-
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
----
N
S
H
G
E
R
I
I
S
A
-
N
P
S
-
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
-
3
PsiBlast_PDB
95.26
46%
-88
- C2 -
3SLC
1
ACKA_SALTY
A:
[16-409]
M
S
S
K
L
V
L
V
L
N
C
G
S
S
S
L
K
F
A
I
I
D
A
V
N
G
D
E
Y
L
S
G
L
A
E
C
F
H
L
P
E
A
R
I
K
W
K
-
M
D
G
S
K
-
Q
E
A
A
L
G
A
G
A
A
H
--
S
E
A
L
N
F
I
-
V
N
-
T
I
LAQ
K
------
P
-
E
-----
L
---
S
-----
A
------
Q
L
T
A
I
G
H
R
I
V
H
G
G
E
K
Y
T
S
S
V
V
I
D
E
S
V
I
Q
G
I
K
D
S
A
S
F
A
P
L
H
N
P
A
H
L
I
G
I
A
E
A
L
K
S
F
P
Q
L
K
DK
N
V
A
V
F
D
T
A
F
H
Q
T
M
P
E
E
S
Y
L
Y
A
L
P
Y
S
L
Y
K
E
H
G
V
R
R
Y
G
A
H
G
T
S
H
F
Y
V
T
Q
E
A
A
K
M
L
N
K
P
V
E
E
L
N
I
I
T
C
H
L
G
N
G
G
S
V
S
A
I
R
N
G
K
C
V
D
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
I
D
P
A
I
I
F
H
L
H
D
T
L
G
M
S
V
D
Q
I
N
K
M
L
T
K
E
S
G
L
L
G
L
T
-
E
-
V
T
S
D
C
R
Y
V
E
-
D
N
Y
A
T
K
E
D
A
K
R
A
M
D
V
Y
C
H
R
L
A
K
Y
I
G
S
Y
T
A
L
M
D
G
R
L
D
A
V
V
F
T
G
G
I
G
E
N
A
A
M
V
R
E
L
S
L
G
K
L
G
V
L
G
F
E
V
D
H
E
R
N
L
A
A
R
---
F
G
K
S
G
F
I
N
K
E
-
G
T
R
-
P
A
V
--
V
I
P
T
N
E
E
L
V
I
A
Q
D
A
S
R
L
T
A
-
22
PsiBlast_CBE
95.25
46%
-91
- C2 -
3SLC
3
ACKA_SALTY
B:
[18-409]
--
S
K
L
V
L
V
L
N
C
G
S
S
S
L
K
F
A
I
I
D
A
V
N
G
D
E
Y
L
S
G
L
A
E
C
F
H
L
P
E
A
R
I
K
W
K
-
M
D
G
S
K
-
Q
E
A
A
L
G
A
G
A
A
H
--
S
E
A
L
N
F
I
-
V
N
-
T
I
L
A
Q
K
------
P
-
E
-----
L
---
S
-----
A
------
Q
L
T
A
I
G
H
R
I
V
H
G
G
E
K
Y
T
S
S
V
V
I
D
E
S
V
I
Q
G
I
K
D
S
A
S
F
A
P
L
H
N
P
A
H
L
I
G
I
A
E
A
L
K
S
F
P
Q
L
K
DK
N
V
A
V
F
D
T
A
F
H
Q
T
M
P
E
E
S
Y
L
Y
A
L
P
Y
S
L
Y
K
E
H
G
V
R
R
Y
G
A
H
G
T
S
H
F
Y
V
T
Q
E
A
A
K
M
L
N
K
P
V
E
E
L
N
I
I
T
C
H
L
G
N
G
G
S
V
S
A
I
R
N
G
K
C
V
D
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
I
D
P
A
I
I
F
H
L
H
D
T
L
G
M
S
V
D
Q
I
N
K
M
L
T
K
E
S
G
L
L
G
L
T
-
E
-
V
T
S
D
C
R
Y
V
E
-
D
N
Y
A
T
K
E
D
A
K
R
A
M
D
V
Y
C
H
R
L
A
K
Y
I
G
S
Y
T
A
L
M
D
G
R
L
D
A
V
V
F
T
G
G
I
G
E
N
A
A
M
V
R
E
L
S
L
G
K
L
G
V
L
G
F
E
V
D
H
E
R
N
L
A
A
R
---
F
G
K
S
G
F
I
N
K
E
-
G
T
R
-
P
A
V
--
V
I
P
T
N
E
E
L
V
I
A
Q
D
A
S
R
L
T
A
-
9
PsiBlast_PDB
95.25
48%
-95
- C2 -
2E1Z
2
TDCD_SALTY
A:
[20-405]
-----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
----
G
D
-
K
-
P
I
N
L
A
H
S
N
Y
--
E
D
A
L
K
A
I
A
F
E
-
L
E
---
K
------
R
-
D
-----
L
---
T
-----
D
------
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
--
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
-
L
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
-
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
----
N
S
H
G
E
R
I
I
S
A
-
N
P
S
-
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
-
11
PsiBlast_PDB
95.14
48%
-96
- C2 -
4FWK
2
TDCD_SALTY
A:
[20-405]
-----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
----
G
D
-
K
-
P
I
N
L
A
H
S
N
Y
--
E
D
A
L
K
A
I
A
F
E
-
L
E
---
K
------
R
-
D
-----
L
---
T
-----
D
------
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
--
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
-
L
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
-
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
----
N
S
H
G
E
R
I
I
S
A
-
N
P
S
-
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
-
7
PsiBlast_PDB
95.00
48%
-95
- C2 -
1X3N
2
TDCD_SALTY
A:
[20-405]
-----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
----
G
D
-
K
-
P
I
N
L
A
H
S
N
Y
--
E
D
A
L
K
A
I
A
F
E
-
L
E
---
K
------
R
-
D
-----
L
---
T
-----
D
------
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
--
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
-
L
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
-
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
----
N
S
H
G
E
R
I
I
S
A
-
N
P
S
-
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
-
10
PsiBlast_PDB
94.90
48%
-94
- C2 -
2E20
2
TDCD_SALTY
A:
[20-405]
-----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
----
G
D
-
K
-
P
I
N
L
A
H
S
N
Y
--
E
D
A
L
K
A
I
A
F
E
-
L
E
---
K
------
R
-
D
-----
L
---
T
-----
D
------
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
--
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
-
L
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
-
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
----
N
S
H
G
E
R
I
I
S
A
-
N
P
S
-
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
-
5
PsiBlast_PDB
94.70
48%
-94
- C2 -
4FWM
4
TDCD_SALTY
A:
[20-405]
-----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
----
G
D
-
K
-
P
I
N
L
A
H
S
N
Y
--
E
D
A
L
K
A
I
A
F
E
-
L
E
---
K
------
R
-
D
-----
L
---
T
-----
D
------
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
--
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
-
L
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
-
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
----
N
S
H
G
E
R
I
I
S
A
-
N
P
S
-
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
-
17
PsiBlast_PDB
94.64
48%
-93
- C2 -
4FWS
5
TDCD_SALTY
A:
[20-405]
-----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
----
G
D
-
K
-
P
I
N
L
A
H
S
N
Y
--
E
D
A
L
K
A
I
A
F
E
-
L
E
---
K
------
R
-
D
-----
L
---
T
-----
D
------
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
--
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
-
L
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
-
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
----
N
S
H
G
E
R
I
I
S
A
-
N
P
S
-
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
-
15
PsiBlast_PDB
94.64
48%
-91
- C2 -
4FWQ
3
TDCD_SALTY
A:
[20-405]
-----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
----
G
D
-
K
-
P
I
N
L
A
H
S
N
Y
--
E
D
A
L
K
A
I
A
F
E
-
L
E
---
K
------
R
-
D
-----
L
---
T
-----
D
------
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
--
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
-
L
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
-
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
----
N
S
H
G
E
R
I
I
S
A
-
N
P
S
-
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
-
16
PsiBlast_PDB
94.59
48%
-92
- C2 -
4FWR
3
TDCD_SALTY
A:
[20-405]
-----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
----
G
D
-
K
-
P
I
N
L
A
H
S
N
Y
--
E
D
A
L
K
A
I
A
F
E
-
L
E
---
K
------
R
-
D
-----
L
---
T
-----
D
------
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
--
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
-
L
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
-
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
----
N
S
H
G
E
R
I
I
S
A
-
N
P
S
-
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
-
13
PsiBlast_PDB
94.54
48%
-95
- C2 -
4FWO
4
TDCD_SALTY
A:
[20-405]
-----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
----
G
D
-
K
-
P
I
N
L
A
H
S
N
Y
--
E
D
A
L
K
A
I
A
F
E
-
L
E
---
K
------
R
-
D
-----
L
---
T
-----
D
------
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
--
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
-
L
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
-
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
----
N
S
H
G
E
R
I
I
S
A
-
N
P
S
-
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
-
26
PsiBlast_CBE
94.31
42%
-90
- C2 -
1G99
2
ACKA_METTE
B:
[2-397]
----
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
G
L
C
E
R
I
G
I
D
N
S
I
I
T
Q
K
-
K
F
D
G
K
-
K
L
E
K
L
T
D
L
P
T
H
--
K
D
A
L
E
E
V
-
V
K
A
L
T
---
D
------
D
-
E
-----
F
---
G
VIKDM
G
------
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
--
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
-
G
-
L
S
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
-
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
--
I
---
R
G
Q
E
I
D
I
S
T
P
D
A
K
V
-
R
V
F
--
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
E
-
45
HHSearch
94.22
43%
-87
- C2 -
1G99
2
ACKA_METTE
A:
[1-397]
---
M
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
G
L
C
E
R
I
G
I
D
N
S
I
I
T
Q
K
-
K
-
F
D
G
K
K
L
E
K
L
T
D
L
P
T
H
--
K
D
A
L
E
E
V
-
V
K
-
A
L
---
T
------
D
D
E
FGVIK
D
---
M
-----
G
------
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
--
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
-
G
-
L
S
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
-
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
I
R
-----
G
Q
E
I
D
I
S
T
P
-
D
A
K
V
R
V
F
--
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
E
-
12
PsiBlast_PDB
94.10
48%
-92
- C2 -
4FWN
3
TDCD_SALTY
A:
[20-405]
-----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
----
G
D
-
K
-
P
I
N
L
A
H
S
N
Y
--
E
D
A
L
K
A
I
A
F
E
-
L
E
---
K
------
R
-
D
-----
L
---
T
-----
D
------
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
--
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
-
L
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
-
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
----
N
S
H
G
E
R
I
I
S
A
-
N
P
S
-
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
-
25
PsiBlast_CBE
94.05
42%
-88
- C2 -
1TUU
3
ACKA_METTE
B:
[2-397]
----
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
G
L
C
E
R
I
G
I
D
N
S
I
I
T
Q
K
-
K
F
D
G
K
-
K
L
E
K
L
T
D
L
P
T
H
--
K
D
A
L
E
E
V
-
V
K
A
L
T
---
D
------
D
-
E
-----
F
---
G
VIKDM
G
------
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
--
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
-
G
-
L
S
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
-
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
--
I
---
R
G
Q
E
I
D
I
S
T
P
D
A
K
V
-
R
V
F
--
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
E
-
6
PsiBlast_PDB
93.96
48%
-92
- C2 -
1X3M
1
TDCD_SALTY
A:
[20-405]
-----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
----
G
D
-
K
-
P
I
N
L
A
H
S
N
Y
--
E
D
A
L
K
A
I
A
F
E
-
L
E
---
K
------
R
-
D
-----
L
---
T
-----
D
------
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
--
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
-
L
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
-
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
----
N
S
H
G
E
R
I
I
S
A
-
N
P
S
-
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
-
20
PsiBlast_PDB
93.60
42%
-85
- C2 -
1G99
2
ACKA_METTE
A:
[2-397]
----
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
G
L
C
E
R
I
G
I
D
N
S
I
I
T
Q
K
-
K
F
D
G
K
-
K
L
E
K
L
T
D
L
P
T
H
--
K
D
A
L
E
E
V
-
V
K
A
L
T
---
D
------
D
-
E
-----
F
---
G
VIKDM
G
------
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
--
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
-
G
-
L
S
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
-
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
--
I
---
R
G
Q
E
I
D
I
S
T
P
D
A
K
V
-
R
V
F
--
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
E
-
24
PsiBlast_CBE
93.56
42%
-87
- C2 -
1TUY
3
ACKA_METTE
B:
[2-397]
----
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
G
L
C
E
R
I
G
I
D
N
S
I
I
T
Q
K
-
K
F
D
G
K
-
K
L
E
K
L
T
D
L
P
T
H
--
K
D
A
L
E
E
V
-
V
K
A
L
T
---
D
------
D
-
E
-----
F
---
G
VIKDM
G
------
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
--
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
-
G
-
L
S
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
-
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
--
I
---
R
G
Q
E
I
D
I
S
T
P
D
A
K
V
-
R
V
F
--
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
E
-
27
PsiBlast_CBE
93.41
43%
-95
- C2 -
3R9P
1
ACKA_MYCPA
B:
[11-389]
--
A
R
R
V
L
V
I
N
S
G
S
S
S
L
K
F
Q
L
V
D
P
E
F
G
V
A
A
S
T
G
I
V
E
R
I
G
E
--
S
------------------
P
V
P
D
H
--
D
A
A
L
R
R
A
-
F
D
-
M
L
---
A
G
D
GVDL
N
-
T
-----
A
---
G
-------------
L
V
A
V
G
H
R
V
V
H
G
G
N
T
F
Y
R
P
T
V
L
D
D
A
V
I
A
R
L
H
E
L
S
E
L
A
P
L
H
N
P
P
A
L
Q
G
I
E
V
A
R
R
L
L
P
D
I
A
--
H
V
A
V
F
D
T
G
F
F
H
D
L
P
P
A
A
A
T
Y
A
I
D
R
E
L
A
D
R
W
Q
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
E
Q
A
A
A
F
L
D
R
P
L
R
G
L
K
Q
I
V
L
H
L
G
N
G
C
S
A
S
A
I
A
G
T
R
P
L
D
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
I
D
P
S
I
V
S
Y
L
C
H
T
A
G
M
G
V
D
D
V
E
S
M
L
N
H
R
S
G
V
V
G
L
S
-
G
-
V
-
R
D
F
R
R
L
R
E
L
I
E
S
G
D
G
A
A
Q
L
A
Y
S
V
F
T
H
R
L
R
K
Y
I
G
A
Y
L
A
V
L
G
-
H
T
D
V
I
S
F
T
A
G
I
G
E
N
D
A
A
V
R
R
D
A
V
S
G
M
E
E
L
G
I
V
L
D
E
R
R
N
L
A
G
G
---
K
G
-
A
R
Q
I
S
A
D
-
D
S
P
I
T
V
L
--
V
V
P
T
N
E
E
L
A
I
A
R
D
C
V
R
V
L
G
-
19
PsiBlast_PDB
93.26
42%
-89
- C2 -
1TUY
2
ACKA_METTE
A:
[2-397]
----
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
G
L
C
E
R
I
G
I
D
N
S
I
I
T
Q
K
-
K
F
D
G
K
-
K
L
E
K
L
T
D
L
P
T
H
--
K
D
A
L
E
E
V
-
V
K
A
L
T
---
D
------
D
-
E
-----
F
---
G
VIKDM
G
------
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
--
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
-
G
-
L
S
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
-
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
--
I
---
R
G
Q
E
I
D
I
S
T
P
D
A
K
V
-
R
V
F
--
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
E
-
49
HHSearch
93.01
45%
-89
- C2 -
3R9P
3
ACKA_MYCPA
A:
[12-390]
---
R
R
V
L
V
I
N
S
G
S
S
S
L
K
F
Q
L
V
D
P
E
F
G
V
A
A
S
T
G
I
V
E
R
I
G
E
E
S
------------------
S
P
V
P
D
H
--
D
A
A
L
R
R
A
-
F
D
-
M
L
---
A
------
G
D
G
-----
V
DLN
T
-----
A
------
G
L
V
A
V
G
H
R
V
V
H
G
G
N
T
F
Y
R
P
T
V
L
D
D
A
V
I
A
R
L
H
E
L
S
E
L
A
P
L
H
N
P
P
A
L
Q
G
I
E
V
A
R
R
L
L
P
D
I
A
--
H
V
A
V
F
D
T
G
F
F
H
D
L
P
P
A
A
A
T
Y
A
I
D
R
E
L
A
D
R
W
Q
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
E
Q
A
A
A
F
L
D
R
P
L
R
G
L
K
Q
I
V
L
H
L
G
N
G
C
S
A
S
A
I
A
G
T
R
P
L
D
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
I
D
P
S
I
V
S
Y
L
C
H
T
A
G
M
G
V
D
D
V
E
S
M
L
N
H
R
S
G
V
V
G
L
S
-
G
--
V
R
D
F
R
R
L
R
E
L
I
E
S
G
D
G
A
A
Q
L
A
Y
S
V
F
T
H
R
L
R
K
Y
I
G
A
Y
L
A
V
L
G
-
H
T
D
V
I
S
F
T
A
G
I
G
E
N
D
A
A
V
R
R
D
A
V
S
G
M
E
E
L
G
I
V
L
D
E
R
R
N
L
A
G
----
G
K
G
A
R
Q
I
S
A
D
-
D
S
P
I
T
V
L
--
V
V
P
T
N
E
E
L
A
I
A
R
D
C
V
R
V
L
G
-
36
Fugue
92.92
42%
-85
- C2 -
1G99
2
ACKA_METTE
A:
[1-398]
---
M
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
G
L
C
E
R
I
G
I
D
N
S
I
I
T
Q
K
K
F
-
D
G
K
-
K
L
E
K
L
T
D
L
P
T
H
--
K
D
A
L
E
E
V
-
V
K
-
A
L
---
T
------
D
-
D
-----
E
---
F
-----
G
VIKDMG
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
--
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
-
G
-
L
S
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
-
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
I
R
G
---
Q
E
I
D
-
I
S
T
P
D
-
A
K
V
-
R
V
F
--
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
E
T
28
PsiBlast_CBE
92.56
43%
-92
- C2 -
3R9P
3
ACKA_MYCPA
A:
[12-389]
---
R
R
V
L
V
I
N
S
G
S
S
S
L
K
F
Q
L
V
D
P
E
F
G
V
A
A
S
T
G
I
V
E
R
I
G
E
E
S
S
------------------
P
V
P
D
H
--
D
A
A
L
R
R
A
-
F
D
-
M
L
---
A
G
D
GVDL
N
-
T
-----
A
---
G
-------------
L
V
A
V
G
H
R
V
V
H
G
G
N
T
F
Y
R
P
T
V
L
D
D
A
V
I
A
R
L
H
E
L
S
E
L
A
P
L
H
N
P
P
A
L
Q
G
I
E
V
A
R
R
L
L
P
D
I
A
--
H
V
A
V
F
D
T
G
F
F
H
D
L
P
P
A
A
A
T
Y
A
I
D
R
E
L
A
D
R
W
Q
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
E
Q
A
A
A
F
L
D
R
P
L
R
G
L
K
Q
I
V
L
H
L
G
N
G
C
S
A
S
A
I
A
G
T
R
P
L
D
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
I
D
P
S
I
V
S
Y
L
C
H
T
A
G
M
G
V
D
D
V
E
S
M
L
N
H
R
S
G
V
V
G
L
S
-
G
-
V
-
R
D
F
R
R
L
R
E
L
I
E
S
G
D
G
A
A
Q
L
A
Y
S
V
F
T
H
R
L
R
K
Y
I
G
A
Y
L
A
V
L
G
-
H
T
D
V
I
S
F
T
A
G
I
G
E
N
D
A
A
V
R
R
D
A
V
S
G
M
E
E
L
G
I
V
L
D
E
R
R
N
L
A
G
G
---
K
G
-
A
R
Q
I
S
A
D
-
D
S
P
I
T
V
L
--
V
V
P
T
N
E
E
L
A
I
A
R
D
C
V
R
V
L
G
-
18
PsiBlast_PDB
92.50
42%
-85
- C2 -
1TUU
2
ACKA_METTE
A:
[2-397]
----
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
G
L
C
E
R
I
G
I
D
N
S
I
I
T
Q
K
-
K
F
D
G
K
-
K
L
E
K
L
T
D
L
P
T
H
--
K
D
A
L
E
E
V
-
V
K
A
L
T
---
D
------
D
-
E
-----
F
---
G
VIKDM
G
------
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
--
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
-
G
-
L
S
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
-
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
--
I
---
R
G
Q
E
I
D
I
S
T
P
D
A
K
V
-
R
V
F
--
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
E
-
29
PsiBlast_CBE
92.48
43%
-93
- C2 -
4IZ9
7
ACKA_MYCA1
A:
[12-390]
--
A
R
R
V
L
V
I
N
S
G
S
S
S
L
K
F
Q
L
V
D
P
E
S
G
V
A
A
S
T
G
I
V
E
R
I
G
E
--
S
------------------
P
V
P
D
H
--
D
A
A
L
R
R
A
-
F
D
-
M
L
---
A
G
D
GVDL
N
-
T
-----
A
---
G
-------------
L
V
A
V
G
H
R
V
V
H
G
G
N
T
F
Y
R
P
T
V
L
D
D
A
V
I
A
R
L
H
E
L
S
E
L
A
P
L
H
N
P
P
A
L
L
G
I
E
V
A
R
R
L
L
P
G
I
A
--
H
V
A
V
F
D
T
G
F
F
H
D
L
P
P
A
A
A
T
Y
A
I
D
R
E
L
A
D
R
W
Q
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
E
Q
A
A
A
F
L
D
R
P
L
R
G
L
K
Q
I
V
L
H
L
G
N
G
C
S
A
S
A
I
A
G
T
R
P
L
D
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
I
D
P
S
V
V
S
Y
L
C
H
T
A
G
M
G
V
D
D
V
E
S
M
L
N
H
R
S
G
V
V
G
L
S
-
G
-
V
-
R
D
F
R
R
L
R
E
L
I
E
S
G
D
G
A
A
Q
L
A
Y
S
V
F
T
H
R
L
R
K
Y
I
G
A
Y
L
A
V
L
G
-
H
T
D
V
I
S
F
T
A
G
I
G
E
N
D
A
A
V
R
R
D
A
V
S
G
M
E
E
L
G
I
V
L
D
E
R
R
N
L
P
G
A
---
K
G
-
A
R
Q
I
S
A
D
-
D
S
P
I
T
V
L
--
V
V
P
T
N
E
E
L
A
I
A
R
D
C
V
R
V
L
G
-
31
PsiBlast_CBE
87.68
42%
-90
- C2 -
4IJN
4
ACKA_MYCS2
A:
[24-391]
----
T
V
L
V
V
N
S
G
S
S
S
L
K
Y
A
V
V
R
P
A
S
G
E
F
L
A
D
G
I
I
E
E
I
G
S
G
------------------
A
V
P
D
H
D
A
A
L
R
A
A
F
D
E
L
-
A
A
-
A
G
---
L
------
H
-
L
-----
E
---
D
-----
L
------
D
L
K
A
V
G
H
R
M
V
H
G
G
K
T
F
Y
K
P
S
V
V
D
D
E
L
I
A
K
A
R
E
L
S
P
L
A
P
L
H
N
P
P
A
I
K
G
I
E
V
A
R
K
L
L
P
D
L
P
--
H
I
A
V
F
D
T
A
F
F
H
D
L
P
A
P
A
S
T
Y
A
I
D
R
E
L
A
E
T
W
H
I
K
R
Y
G
F
H
G
T
S
H
E
Y
V
S
Q
Q
A
A
I
F
L
D
R
P
L
E
S
L
N
Q
I
V
L
H
L
G
N
G
A
S
A
S
A
V
A
G
G
K
A
V
D
T
S
M
G
L
T
P
M
E
G
L
V
M
G
T
R
S
G
D
I
D
P
G
V
I
M
Y
L
W
R
T
A
G
M
S
V
D
D
I
E
S
M
L
N
R
R
S
G
V
L
G
L
G
-
G
-
A
S
-
D
F
R
K
L
R
E
L
I
E
S
G
D
E
H
A
K
L
A
Y
D
V
Y
I
H
R
L
R
K
Y
I
G
A
Y
M
A
V
L
G
-
R
T
D
V
I
S
F
T
A
G
V
G
E
N
V
P
P
V
R
R
D
A
L
A
G
L
G
G
L
G
I
E
I
D
D
A
L
N
S
A
K
S
DEP
R
L
I
S
T
P
D
S
R
V
-----
T
V
L
--
V
V
P
T
N
E
E
L
A
I
A
R
A
C
V
G
V
---
30
PsiBlast_CBE
87.29
42%
-87
- C2 -
4IJN
3
ACKA_MYCS2
B:
[24-391]
----
T
V
L
V
V
N
S
G
S
S
S
L
K
Y
A
V
V
R
P
A
S
G
E
F
L
A
D
G
I
I
E
E
I
G
S
G
------------------
A
V
P
D
H
D
A
A
L
R
A
A
F
D
E
L
-
A
A
-
A
G
---
L
------
H
-
L
-----
E
---
D
-----
L
------
D
L
K
A
V
G
H
R
M
V
H
G
G
K
T
F
Y
K
P
S
V
V
D
D
E
L
I
A
K
A
R
E
L
S
P
L
A
P
L
H
N
P
P
A
I
K
G
I
E
V
A
R
K
L
L
P
D
L
P
--
H
I
A
V
F
D
T
A
F
F
H
D
L
P
A
P
A
S
T
Y
A
I
D
R
E
L
A
E
T
W
H
I
K
R
Y
G
F
H
G
T
S
H
E
Y
V
S
Q
Q
A
A
I
F
L
D
R
P
L
E
S
L
N
Q
I
V
L
H
L
G
N
G
A
S
A
S
A
V
A
G
G
K
A
V
D
T
S
M
G
L
T
P
M
E
G
L
V
M
G
T
R
S
G
D
I
D
P
G
V
I
M
Y
L
W
R
T
A
G
M
S
V
D
D
I
E
S
M
L
N
R
R
S
G
V
L
G
L
G
-
G
-
A
S
-
D
F
R
K
L
R
E
L
I
E
S
G
D
E
H
A
K
L
A
Y
D
V
Y
I
H
R
L
R
K
Y
I
G
A
Y
M
A
V
L
G
-
R
T
D
V
I
S
F
T
A
G
V
G
E
N
V
P
P
V
R
R
D
A
L
A
G
L
G
G
L
G
I
E
I
D
D
A
L
N
S
A
K
S
DEP
R
L
I
S
T
P
D
S
R
V
-----
T
V
L
--
V
V
P
T
N
E
E
L
A
I
A
R
A
C
V
G
V
---