@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0870: (2016-01-22 )
MSHFAKVARVPGDPILGLLDAYRNDPRADKLDLGVGVYKDAQGLTPILRSVKLAEQRLVEQETTKSYVGGHGDALFAARLAELALGAASPLLLEQRADATQTPGGTGALRLAGDFIAHCLPGRGIWLSDPTWPIHETLFAAAGLKVSHYPYVSADNRLDVEAMLAGLERIPQGDVVLLHACCHNPTGFDLSHDDWRRVLDVVRRRELLPLIDFAYQGFGDGLEEDAWAVRLFAGELPEVLVTSSCSKNFGLYRDRVGALIVCAQNAEKLTDLRSQLAFLARNLWSTPPAHGAEVVAAILGDSELKGLWQEEVEGMRSRIASLRIGLVEALAPHGLAERFAHVGAQRGMFSYTGLSPQQVARLRDEHAVYLVSSGRANVAGLDARRLDRLAQAIAQVCAD
Atome Classification :
(95 SA)
.........10........20........30........40........50........60-.........70........80........90........100.......110....--...-----120.......130.......140.......150-..-...-..160.......170.......180.......190.......200.......210.......220..-.....230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
H
F
A
K
V
ARVPG
D
P
I
L
G
L
L
D
A
YRNDPRADKLDLGVGVYKDAQ
G
L
T
P
I
L
R
S
V
K
L
A
E
Q
R
L
V
E
--
Q
E
T
T
K
S
YVGGH
G
D
A
L
F
A
A
R
L
A
E
L
A
LGAAS
P
L
L
L
E
QRADATQTPGGT
G
A
L
R
L
A
G
D
F
I
--
A
H
C-----LPGR
G
I
WLSDPTW
P
I
H
E
T
L
F
A
AAGLKVSHYPYV-SA-DNR-L
D
V
E
A
M
L
A
G
L
E
RIPQG
D
V
V
L
L
H
A
CCHNPTGFDL
S
H
D
D
W
R
R
V
L
D
V
V
R
R
R
EL
L
P
L
I
D
F
A
Y
Q
GFGDGLEE-D
A
W
A
V
R
L
F
AGEL
P
E
V
L
V
TSSCSKNFG
L
Y
R
DRV
G
A
L
I
V
CAQ
N
A
E
K
L
T
D
L
R
S
Q
L
A
F
L
A
R
N
LWSTPPAH
G
A
E
V
V
A
A
I
LG
D
S
E
L
K
G
L
W
Q
E
E
V
E
G
M
R
S
R
I
A
S
L
R
I
G
L
V
E
A
LAP
H
G
L
A
E
R
F
A
H
V
G
A
QRGMFSYTGL
S
P
Q
Q
V
A
R
LRDE
H
A
V
Y
L
V
SSGRANVAGL
D
A
R
R
L
D
R
L
A
Q
A
I
A
Q
V
CAD
62
PsiBlast_CBE
97.35
46%
-113
- C1 -
1QIR
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
Y
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
21
PsiBlast_CBE
96.52
46%
-113
- C1 -
3QPG
14
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
34
PsiBlast_CBE
96.46
46%
-112
- C1 -
1ARG
2
AAT_ECOLI
B:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
8
PsiBlast_PDB
96.34
46%
-108
- C1 -
1ARG
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
71
PsiBlast_CBE
96.31
47%
-110
- C1 -
1YOO
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
T
A
P
A
D
P
I
L
G
L
A
D
L
L
R
A
D
E
R
P
G
K
I
D
L
G
M
G
V
Y
N
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
R
R
V
W
V
S
N
P
G
W
P
T
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
T
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
V
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
G
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
T
I
K
Q
N
G
M
F
F
F
G
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
L
N
V
A
G
M
T
P
D
N
L
A
P
L
C
E
A
I
V
A
V
L
--
25
PsiBlast_CBE
96.04
46%
-110
- C1 -
1X29
2
AAT_ECOLI
B:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
61
PsiBlast_CBE
95.48
46%
-112
- C1 -
1QIS
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
F
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
63
PsiBlast_CBE
95.25
46%
-110
- C1 -
1QIT
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
W
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
37
PsiBlast_CBE
95.18
46%
-107
- C1 -
1IX7
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
F
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
13
PsiBlast_PDB
95.15
46%
-109
- C1 -
1X28
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
70
PsiBlast_CBE
95.06
47%
-110
- C1 -
1CZC
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
T
A
P
A
D
P
I
L
G
L
A
D
L
L
R
A
D
E
R
P
G
K
I
D
L
G
M
G
V
Y
N
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
R
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
T
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
V
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
G
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
T
I
K
Q
N
G
M
F
F
F
G
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
L
N
V
A
G
M
T
P
D
N
L
A
P
L
C
E
A
I
V
A
V
L
--
86
PsiBlast_CBE
94.91
45%
-109
- C1 -
1AHX
4
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
L
Y
Y
D
E
T
G
K
I
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
L
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
S
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
69
PsiBlast_CBE
94.80
47%
-108
- C1 -
1CZE
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
T
A
P
A
D
P
I
L
G
L
A
D
L
L
R
A
D
E
R
P
G
K
I
D
L
G
M
G
V
Y
N
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
R
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
T
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
V
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
G
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
T
I
K
Q
N
G
M
F
F
F
G
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
L
N
V
A
G
M
T
P
D
N
L
A
P
L
C
E
A
I
V
A
V
L
--
33
PsiBlast_CBE
94.78
46%
-110
- C1 -
1ART
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
35
PsiBlast_CBE
94.75
46%
-110
- C1 -
1ASG
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
F
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
15
PsiBlast_PDB
94.62
46%
-110
- C1 -
1X2A
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
50
PsiBlast_CBE
94.60
46%
-110
- C1 -
2D63
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
T
A
P
A
D
P
I
L
G
L
A
D
L
L
R
A
D
E
R
P
G
K
I
D
L
G
M
G
V
Y
N
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
V
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
7
PsiBlast_PDB
94.43
46%
-107
- C1 -
1ASN
3
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
53
PsiBlast_CBE
94.29
46%
-109
- C1 -
1SPA
1
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
A
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
20
PsiBlast_PDB
94.26
46%
-110
- C1 -
1ARS
1
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
65
PsiBlast_CBE
94.22
46%
-108
- C1 -
2D5Y
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
T
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
V
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
T
I
K
Q
N
G
M
F
F
F
G
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
L
N
V
A
G
M
T
P
D
N
L
A
P
L
C
E
A
I
V
A
V
L
--
38
PsiBlast_CBE
94.16
46%
-109
- C1 -
1IX6
1
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
F
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
99
PsiBlast_CBE
94.15
45%
-111
- C1 -
1TOI
1
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
L
Y
Y
D
E
T
G
K
I
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
L
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
S
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
D
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
94
PsiBlast_CBE
94.15
45%
-109
- C1 -
1TOG
2
AAT_ECOLI
B:
[2-395]
---
F
E
N
I
T
A
T
T
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
D
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
S
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
A
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
G
Q
M
K
A
A
I
R
D
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
42
PsiBlast_CBE
94.14
46%
-110
- C1 -
1AIC
4
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
H
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
23
PsiBlast_CBE
94.13
46%
-110
- C1 -
3PA9
17
?
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
83
PsiBlast_CBE
94.11
45%
-109
- C1 -
1AHY
4
AAT_ECOLI
B:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
L
Y
Y
D
E
T
G
K
I
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
L
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
S
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
64
PsiBlast_CBE
94.06
46%
-111
- C1 -
1G4V
1
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
A
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
F
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
47
PsiBlast_CBE
94.05
46%
-113
- C1 -
4DBC
6
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
A
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
73
PsiBlast_CBE
94.01
46%
-108
- C1 -
1G4X
1
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
A
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
L
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
43
PsiBlast_CBE
94.01
46%
-108
- C1 -
1AIB
4
AAT_ECOLI
B:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
H
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
60
PsiBlast_CBE
93.97
46%
-110
- C1 -
1B4X
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
S
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
29
PsiBlast_CBE
93.96
46%
-109
- C1 -
1ASL
2
AAT_ECOLI
B:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
85
PsiBlast_CBE
93.89
45%
-109
- C1 -
1AHX
4
AAT_ECOLI
B:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
L
Y
Y
D
E
T
G
K
I
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
L
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
S
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
17
PsiBlast_PDB
93.86
46%
-109
- C1 -
1AMQ
1
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
12
PsiBlast_PDB
93.84
46%
-107
- C1 -
1CQ8
1
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
72
PsiBlast_CBE
93.80
46%
-108
- C1 -
1G7W
1
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
A
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
L
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
14
PsiBlast_PDB
93.78
46%
-108
- C1 -
1X29
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
68
PsiBlast_CBE
93.75
46%
-111
- C1 -
1ARI
4
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
H
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
98
PsiBlast_CBE
93.72
45%
-111
- C1 -
1TOJ
1
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
T
T
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
D
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
S
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
A
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
G
Q
M
K
A
A
I
R
A
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
82
PsiBlast_CBE
93.70
46%
-110
- C1 -
2D64
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
T
A
P
A
D
P
I
L
G
L
A
D
L
L
R
A
D
E
R
P
G
K
I
D
L
G
M
G
V
Y
N
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
G
W
P
T
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
V
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
T
I
K
Q
N
G
M
F
F
F
G
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
L
N
V
A
G
M
T
P
D
N
L
A
P
L
C
E
A
I
V
A
V
L
--
19
PsiBlast_PDB
93.66
46%
-108
- C1 -
1AMS
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
97
PsiBlast_CBE
93.62
45%
-110
- C1 -
1TOK
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
T
T
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
D
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
S
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
A
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
G
Q
M
K
A
A
I
R
A
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
30
PsiBlast_CBE
93.62
46%
-110
- C1 -
1ASE
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
28
PsiBlast_CBE
93.58
46%
-111
- C1 -
1ASM
4
AAT_ECOLI
B:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
93
PsiBlast_CBE
93.57
46%
-108
- C1 -
1G7X
1
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
A
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
L
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
L
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
26
PsiBlast_CBE
93.49
46%
-112
- C1 -
1X28
2
AAT_ECOLI
B:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
84
PsiBlast_CBE
93.43
45%
-108
- C1 -
1AHY
4
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
L
Y
Y
D
E
T
G
K
I
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
L
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
S
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
24
PsiBlast_CBE
93.43
46%
-108
- C1 -
1X2A
2
AAT_ECOLI
B:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
96
PsiBlast_CBE
93.35
45%
-112
- C1 -
1TOK
2
AAT_ECOLI
B:
[2-395]
---
F
E
N
I
T
A
T
T
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
D
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
S
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
A
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
G
Q
M
K
A
A
I
R
A
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
87
PsiBlast_CBE
93.35
45%
-110
- C1 -
1AHG
2
AAT_ECOLI
B:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
L
Y
Y
D
E
T
G
K
I
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
L
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
S
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
9
PsiBlast_PDB
93.25
46%
-110
- C1 -
1C9C
1
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
75
PsiBlast_CBE
93.21
46%
-108
- C1 -
1ARH
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
R
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
A
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
74
PsiBlast_CBE
93.20
46%
-108
- C1 -
1ARH
2
AAT_ECOLI
B:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
R
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
A
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
10
PsiBlast_PDB
93.13
46%
-107
- C1 -
1CQ6
1
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
46
PsiBlast_CBE
93.12
46%
-106
- C1 -
1AIA
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
H
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
59
PsiBlast_CBE
93.00
46%
-109
- C1 -
5EAA
1
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
S
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
57
PsiBlast_CBE
92.96
46%
-108
- C1 -
2D7Z
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
T
A
P
A
D
P
I
L
G
L
A
D
L
L
R
A
D
E
R
P
G
K
I
D
L
G
M
G
V
Y
N
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
G
W
P
T
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
V
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
11
PsiBlast_PDB
92.96
46%
-111
- C1 -
1CQ7
1
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
16
PsiBlast_PDB
92.94
46%
-112
- C1 -
1AAW
1
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
92
PsiBlast_CBE
92.91
45%
-106
- C1 -
1AHE
3
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
L
Y
Y
D
E
T
G
K
I
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
L
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
S
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
18
PsiBlast_PDB
92.91
46%
-111
- C1 -
1AMR
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
22
PsiBlast_CBE
92.76
46%
-111
- C1 -
3PAA
17
?
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
5
PsiBlast_PDB
92.72
46%
-109
- C1 -
1ASL
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
1
PsiBlast_PDB
92.65
47%
-112
- C1 -
4F5L
6
AAT_ECOLI
A:
[12-405]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
V
D
L
G
V
G
V
Y
K
D
E
T
G
K
T
P
V
M
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
T
Y
L
G
L
D
G
L
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
S
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
T
W
P
N
H
K
A
I
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
A
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
I
D
I
A
Y
Q
G
F
G
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
C
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
I
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
31
PsiBlast_CBE
92.62
46%
-112
- C1 -
1ASD
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
55
PsiBlast_CBE
92.61
46%
-111
- C1 -
1ASB
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
A
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
6
PsiBlast_PDB
92.61
46%
-108
- C1 -
1ASM
4
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
58
PsiBlast_CBE
92.55
46%
-109
- C1 -
2D66
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
T
A
P
A
D
P
I
L
G
L
A
D
L
L
R
A
D
E
R
P
G
K
I
D
L
G
M
G
V
Y
N
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
G
W
P
T
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
V
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
51
PsiBlast_CBE
92.48
46%
-109
- C1 -
2D61
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
T
A
P
A
D
P
I
L
G
L
A
D
L
L
R
A
D
E
R
P
G
K
I
D
L
G
M
G
V
Y
N
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
V
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
81
PsiBlast_CBE
92.42
46%
-110
- C1 -
2D65
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
T
A
P
A
D
P
I
L
G
L
A
D
L
L
R
A
D
E
R
P
G
K
I
D
L
G
M
G
V
Y
N
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
G
W
P
T
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
V
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
T
I
K
Q
N
G
M
F
F
F
G
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
L
N
V
A
G
M
T
P
D
N
L
A
P
L
C
E
A
I
V
A
V
L
--
91
PsiBlast_CBE
92.30
45%
-107
- C1 -
1AHE
3
AAT_ECOLI
B:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
L
Y
Y
D
E
T
G
K
I
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
L
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
S
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
79
PsiBlast_CBE
92.29
46%
-108
- C1 -
3ZZK
10
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
Q
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Q
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
Y
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
49
PsiBlast_CBE
92.24
46%
-108
- C1 -
2D7Y
1
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
T
A
P
A
D
P
I
L
G
L
A
D
L
L
R
A
D
E
R
P
G
K
I
D
L
G
M
G
V
Y
N
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
V
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
67
PsiBlast_CBE
92.22
46%
-110
- C1 -
1ARI
4
AAT_ECOLI
B:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
H
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
89
PsiBlast_CBE
92.09
45%
-110
- C1 -
1AHF
4
AAT_ECOLI
B:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
L
Y
Y
D
E
T
G
K
I
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
L
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
S
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
44
PsiBlast_CBE
92.09
46%
-108
- C1 -
1AIB
4
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
H
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
66
PsiBlast_CBE
92.06
46%
-109
- C1 -
1IX8
1
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
F
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
A
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
90
PsiBlast_CBE
92.05
45%
-107
- C1 -
1AHF
3
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
L
Y
Y
D
E
T
G
K
I
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
L
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
S
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
80
PsiBlast_CBE
92.04
46%
-108
- C1 -
3ZZJ
11
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
Q
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Q
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
Y
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
32
PsiBlast_CBE
92.02
46%
-108
- C1 -
1ASA
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
78
PsiBlast_CBE
92.00
46%
-110
- C1 -
4A00
7
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
Q
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Q
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
Y
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
88
PsiBlast_CBE
91.74
45%
-109
- C1 -
1AHG
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
L
Y
Y
D
E
T
G
K
I
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
L
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
S
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
27
PsiBlast_CBE
91.66
46%
-108
- C1 -
1ASN
3
AAT_ECOLI
B:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
54
PsiBlast_CBE
91.38
46%
-108
- C1 -
1ASC
1
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
A
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
95
PsiBlast_CBE
91.28
45%
-110
- C1 -
1TOG
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
T
T
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
D
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
S
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
A
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
G
Q
M
K
A
A
I
R
D
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
41
PsiBlast_CBE
90.96
46%
-107
- C1 -
1AIC
4
AAT_ECOLI
B:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
H
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
45
PsiBlast_CBE
90.72
46%
-105
- C1 -
1AIA
2
AAT_ECOLI
B:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
H
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
77
PsiBlast_CBE
90.54
46%
-106
- C1 -
4F5M
2
AAT_ECOLI
A:
[12-405]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
36
PsiBlast_CBE
90.32
46%
-109
- C1 -
1ASF
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
F
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
56
PsiBlast_CBE
87.70
46%
-107
- C1 -
3AAT
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
F
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
113
HHSearch
86.43
38%
-101
- C1 -
1AJS
1
AATC_PIG
A:
[3-408]
P
S
V
F
A
E
V
P
Q
A
Q
P
V
L
V
F
K
L
I
A
D
F
R
E
D
P
D
P
R
K
V
N
L
G
V
G
A
Y
R
T
D
D
C
Q
P
W
V
L
P
V
V
R
K
V
E
-
Q
R
I
A
N
N
S
S
L
N
H
E
Y
L
P
I
L
G
L
A
E
F
R
T
C
A
S
R
L
A
L
G
D
D
S
P
A
L
Q
E
K
R
V
G
G
V
Q
S
L
G
G
T
G
A
L
R
I
G
A
E
F
L
--
A
R
W
YNGTN
N
K
D
T
P
V
Y
V
S
S
P
T
W
E
N
H
N
G
V
F
T
T
A
G
F
K
D
I
R
S
Y
R
Y
W
D
T
E
K
R
G
-
L
D
L
Q
G
F
L
S
D
L
E
N
A
P
E
F
S
I
F
V
L
H
A
C
A
H
N
P
T
G
T
D
P
T
P
E
Q
W
K
Q
I
A
S
V
M
K
R
R
F
L
F
P
F
F
D
S
A
Y
Q
G
F
A
S
G
N
L
E
K
D
A
W
A
I
R
Y
F
V
S
E
G
F
E
L
F
C
A
Q
S
F
S
K
N
F
G
L
Y
N
E
R
V
G
N
L
T
V
V
A
K
E
P
D
S
I
L
R
V
L
S
Q
M
Q
K
I
V
R
V
T
W
S
N
P
P
A
Q
G
A
R
I
V
A
R
T
L
S
D
P
E
L
F
H
E
W
T
G
N
V
K
T
M
A
D
R
I
L
S
M
R
S
E
L
R
A
R
L
E
A
L
K
T
P
G
T
W
N
H
I
T
D
Q
I
G
M
F
S
F
T
G
L
N
P
K
Q
V
E
Y
L
I
N
Q
K
H
I
Y
L
L
P
S
G
R
I
N
M
C
G
L
T
T
K
N
L
D
Y
V
A
T
S
I
H
E
A
V
T
K
108
HHSearch
85.29
45%
-102
- C1 -
2AY1
3
TYRB_PARDE
A:
[2-393]
---
L
G
N
L
K
P
Q
A
P
D
K
I
L
A
L
M
G
E
F
R
A
D
P
R
Q
G
K
I
D
L
G
V
G
V
Y
K
D
A
T
G
H
T
P
I
M
R
A
V
H
A
A
E
Q
R
M
L
E
--
T
E
T
T
K
T
Y
A
G
L
S
G
E
P
E
F
Q
K
A
M
G
E
L
I
L
G
-
D
G
L
K
S
E
T
T
A
--
T
L
A
T
V
G
G
T
G
A
L
R
Q
A
L
E
L
A
R
M
A
-------
N
P
D
L
R
V
F
V
S
D
P
T
W
P
N
H
V
S
I
M
N
F
M
G
L
P
V
Q
T
Y
R
Y
F
-
D
A
E
T
R
G
-
V
D
F
E
G
M
K
A
D
L
A
A
A
K
K
G
D
M
V
L
L
H
G
C
C
H
N
P
T
G
A
N
L
T
L
D
Q
W
A
E
I
A
S
I
L
E
K
T
G
A
L
P
L
I
D
L
A
Y
Q
G
F
G
D
G
L
E
E
-
D
A
A
G
T
R
L
I
A
S
R
I
P
E
V
L
I
A
A
S
C
S
K
N
F
G
I
Y
R
E
R
T
G
C
L
L
A
L
C
A
D
A
A
T
R
E
L
A
Q
G
A
M
A
F
L
N
R
Q
T
Y
S
F
P
P
F
H
G
A
K
I
V
S
T
V
L
T
T
P
E
L
R
A
D
W
M
A
E
L
E
A
V
R
S
G
M
L
R
L
R
E
Q
L
A
G
E
L
R
D
L
S
G
S
D
R
F
G
F
V
A
E
H
R
G
M
F
S
R
L
G
A
T
P
E
Q
V
K
R
I
K
E
E
F
G
I
Y
M
V
G
D
S
R
I
N
I
A
G
L
N
D
N
T
I
P
I
L
A
R
A
I
I
E
V
G
V
-
48
PsiBlast_CBE
80.17
46%
-97
- C1 -
2AAT
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
A
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--
52
PsiBlast_CBE
80.00
46%
-101
- C1 -
1AAM
2
AAT_ECOLI
A:
[2-395]
---
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
E
T
G
K
T
P
V
L
T
S
V
K
K
A
E
Q
Y
L
L
E
--
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
A
L
I
N
D
K
R
A
R
T
A
Q
T
P
G
G
T
G
A
L
R
V
A
A
D
F
L
--
A
K
N
-----
T
S
V
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
S
A
G
L
E
V
R
E
Y
A
Y
Y
-
D
A
-
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
A
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
T
L
V
A
A
D
S
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
D
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
G
A
N
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
--