@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0895: (2016-01-24 )
MSAPHAQVERADFDRYMVPNYAPAAFIPVRGEGSRVWDQSGRELIDFAGGIAVTSLGHAHPALVKALTEQAQRIWHVSNVFTNEPALRLARKLVDATFAERVFLANSGAEANEAAFKLARRYANDVYGPQKYEIIAASNSFHGRTLFTVNVGGQPKYSDGFGPKFEGITHVPYNDLEALKAAISDKTCAVVLEPIQGEGGVLPAQQAYLEGARKLCDEHNALLVFDEVQSGMGRVGELFAYMHYGVVPDILSSAKSLGGGFPIGAMLTTGEIAKHLSVGTHGTTYGGNPLASAVAEAALDVINTPEVLDGVKAKHERFKSRLQKIGQEYGIFDEIRGMGLLIGAALTDEWKGKARDVLNAAEKEAVMVLQASPDVVRFAPSLVIDDAEIDEGLERFERAVAKLVRG
Atome Classification :
(44 SA)
------.........10........20--.........30........40........50.......-.60........--70.......-.80--.........90....---..--.---.100.........110.......120....-.-.--.130.--......140.......150......-.160........170.--------------.---------------------.....180.------.-------------.-....190...-....200.......210.......220.......230.......240.......250.......260-........270.....--..280----.........290.......300.......310.......320.......330.......340.......-350....-...360-..-.....370.-...-...380.......390.......400....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------MSAP
H
A
Q
V
E
R
ADFDRYMVPN---YAP
A
A
F
I
P
VRGEGSR
V
W
D
QSGR
E
L
I
D
FAG
G
I
A
V
TSLGH-A
H
P
A
L
V
K
A
L
T
E
--
Q
A
Q
R
I
W
H
V
S
-NV---FTN
E
P
A
L
R
L
A
R
K
L
V
D
---
A
T
--
F
---
A
E
--
R
V
F
L
ANSGAE
A
N
E
A
A
F
K
L
A
R
R
Y
A
N
DV-Y-G--P
Q
K
Y
E
--
I
I
A
ASNSFH
G
R
T
L
F
T
V
NVGGQPKYS-DGF-GPKFE
G
I
T
HVPY--------------
N
---------------------
D
L
E
A
L
K
A
A
I------S-------------D-K
T
C
A
V
V
L
EPI-QGEGGVL
P
A
Q
Q
A
Y
L
E
G
A
R
K
L
C
D
EHN
A
L
L
V
F
D
E
V
Q
S
G
M
G
R
V
G
E
L
F
A
Y
M
H
YGV
V
P
D
I
L
S
S
A
K
SLGGG-F-PI
G
A
M
L
T
T
G
E
I
A
K
H
LS--VGT------HGTTYGG
N
P
L
A
S
A
V
A
E
A
A
L
DVIN
T
P
E
V
L
D
G
V
K
A
K
H
E
R
F
K
S
R
L
Q
K
I
G
Q
EYG
I
F
D
E
IRG
M
G
L
L
I
G
A
AL
T
D
E
-WK
G
K
A
R
D
-
V
L
N
A
AE-K
E
-
A
V
M
V
L
QASP-
D
V
V
-
R
FAPS
L
V
I
D
D
A
E
I
D
E
G
L
E
R
F
E
R
A
V
A
K
L
VRG
6
PsiBlast_PDB
96.35
65%
-95
- C1 -
4JEY
14
ARGD_SALTY
A:
[21-419]
-----------
T
A
I
T
R
A
T
F
D
E
V
I
L
P
V
---
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
--
Q
G
E
T
L
W
H
T
S
-
N
V
---
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
---
A
T
--
F
---
A
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
-
H
-
S
--
P
F
K
T
K
--
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
-
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
--------------
N
---------------------
D
L
H
A
V
K
A
V
M
------
D
-------------
D
-
H
T
C
A
V
V
V
E
P
I
-
Q
G
A
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
------------
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
-
Y
K
G
R
A
R
D
-
F
L
Y
A
G
A
-
E
A
-
G
V
M
V
L
N
A
G
A
-
D
V
M
-
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
A
L
3
PsiBlast_PDB
93.80
65%
-96
- C1 -
4JEW
13
ARGD_SALTY
A:
[21-419]
-----------
T
A
I
T
R
A
T
F
D
E
V
I
L
P
V
---
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
--
Q
G
E
T
L
W
H
T
S
-
N
V
---
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
---
A
T
--
F
---
A
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
-
H
-
S
--
P
F
K
T
K
--
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
-
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
--------------
N
---------------------
D
L
H
A
V
K
A
V
M
------
D
-------------
D
-
H
T
C
A
V
V
V
E
P
I
-
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
-------------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
-
Y
K
G
R
A
R
D
-
F
L
Y
A
G
A
-
E
A
-
G
V
M
V
L
N
A
G
A
-
D
V
M
-
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
A
L
36
PsiBlast_CBE
93.79
60%
-93
- C1 -
4ADB
4
ASTC_ECOLI
B:
[3-401]
--------
Q
P
---
I
T
R
E
N
F
D
E
W
M
I
P
V
---
Y
A
P
A
P
F
I
P
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
--
Q
A
S
K
F
W
H
T
G
-
N
G
---
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
---
A
T
--
F
---
A
D
--
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
R
-
Y
-
G
--
S
H
K
S
G
--
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
-
Q
D
F
-
A
P
L
P
A
D
I
R
H
A
A
Y
--------------
N
---------------------
D
I
N
S
A
S
A
L
I
------
D
-------------
D
-
S
T
C
A
V
I
V
E
P
I
-
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
L
L
A
T
E
E
C
A
R
V
M
T
--
V
G
T
------
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
N
A
D
-
Y
A
G
Q
A
K
Q
-
I
S
Q
E
A
A
-
K
A
-
G
V
M
V
L
I
A
G
G
-
N
V
V
-
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
R
33
PsiBlast_CBE
93.74
60%
-94
- C1 -
4ADC
4
ASTC_ECOLI
B:
[3-401]
--------
Q
P
---
I
T
R
E
N
F
D
E
W
M
I
P
V
---
Y
A
P
A
P
F
I
P
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
--
Q
A
S
K
F
W
H
T
G
-
N
G
---
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
---
A
T
--
F
---
A
D
--
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
R
-
Y
-
G
--
S
H
K
S
G
--
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
-
Q
D
F
-
A
P
L
P
A
D
I
R
H
A
A
Y
--------------
N
---------------------
D
I
N
S
A
S
A
L
I
------
D
-------------
D
-
S
T
C
A
V
I
V
E
P
I
-
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
L
L
A
T
E
E
C
A
R
V
M
T
--
V
G
T
------
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
N
A
D
-
Y
A
G
Q
A
K
Q
-
I
S
Q
E
A
A
-
K
A
-
G
V
M
V
L
I
A
G
G
-
N
V
V
-
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
-
5
PsiBlast_PDB
93.45
65%
-96
- C1 -
4JF1
9
ARGD_SALTY
A:
[27-419]
-----------------
T
F
D
E
V
I
L
P
V
---
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
--
Q
G
E
T
L
W
H
T
S
-
N
V
---
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
---
A
T
--
F
---
A
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
-
H
-
S
--
P
F
K
T
K
--
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
-
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
--------------
N
---------------------
D
L
H
A
V
K
A
V
M
------
D
-------------
D
-
H
T
C
A
V
V
V
E
P
I
-
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
--------------
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
-
Y
K
G
R
A
R
D
-
F
L
Y
A
G
A
-
E
A
-
G
V
M
V
L
N
A
G
A
-
D
V
M
-
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
A
L
12
PsiBlast_PDB
93.30
60%
-93
- C1 -
4ADE
-
ASTC_ECOLI
A:
[3-401]
--------
Q
P
---
I
T
R
E
N
F
D
E
W
M
I
P
V
---
Y
A
P
A
P
F
I
P
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
--
Q
A
S
K
F
W
H
T
G
-
N
G
---
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
---
A
T
--
F
---
A
D
--
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
R
-
Y
-
G
--
S
H
K
S
G
--
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
-
Q
D
F
-
A
P
L
P
A
D
I
R
H
A
A
Y
--------------
N
---------------------
D
I
N
S
A
S
A
L
I
------
D
-------------
D
-
S
T
C
A
V
I
V
E
P
I
-
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
L
L
A
T
E
E
C
A
R
V
M
T
--
V
G
T
------
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
N
A
D
-
Y
A
G
Q
A
K
Q
-
I
S
Q
E
A
A
-
K
A
-
G
V
M
V
L
I
A
G
G
-
N
V
V
-
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
-
1
PsiBlast_PDB
93.15
65%
-95
- C1 -
2PB0
5
ARGD_SALTY
A:
[27-419]
-----------------
T
F
D
E
V
I
L
P
V
---
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
--
Q
G
E
T
L
W
H
T
S
-
N
V
---
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
---
A
T
--
F
---
A
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
-
H
-
S
--
P
F
K
T
K
--
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
-
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
--------------
N
---------------------
D
L
H
A
V
K
A
V
M
------
D
-------------
D
-
H
T
C
A
V
V
V
E
P
I
-
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
-------------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
-
Y
K
G
R
A
R
D
-
F
L
Y
A
G
A
-
E
A
-
G
V
M
V
L
N
A
G
A
-
D
V
M
-
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
A
-
35
PsiBlast_CBE
93.13
60%
-91
- C1 -
4ADB
4
ASTC_ECOLI
C:
[4-401]
---------
P
---
I
T
R
E
N
F
D
E
W
M
I
P
V
---
Y
A
P
A
P
F
I
P
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
--
Q
A
S
K
F
W
H
T
G
-
N
G
---
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
---
A
T
--
F
---
A
D
--
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
R
-
Y
-
G
--
S
H
K
S
G
--
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
-
Q
D
F
-
A
P
L
P
A
D
I
R
H
A
A
Y
--------------
N
---------------------
D
I
N
S
A
S
A
L
I
------
D
-------------
D
-
S
T
C
A
V
I
V
E
P
I
-
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
L
L
A
T
E
E
C
A
R
V
M
T
--
V
G
T
------
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
N
A
D
-
Y
A
G
Q
A
K
Q
-
I
S
Q
E
A
A
-
K
A
-
G
V
M
V
L
I
A
G
G
-
N
V
V
-
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
-
7
PsiBlast_PDB
93.13
65%
-95
- C1 -
4JEZ
14
ARGD_SALTY
A:
[39-419]
--------------------------------
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
--
Q
G
E
T
L
W
H
T
S
-
R
V
---
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
---
A
T
--
F
---
A
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
-
H
-
S
--
P
F
K
T
K
--
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
-
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
--------------
N
---------------------
D
L
H
A
V
K
A
V
M
------
D
-------------
D
-
H
T
C
A
V
V
V
E
P
I
-
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
-------------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
-
Y
K
G
R
A
R
D
-
F
L
Y
A
G
A
-
E
A
-
G
V
M
V
L
N
A
G
A
-
D
V
M
-
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
A
L
31
PsiBlast_CBE
92.91
60%
-92
- C1 -
4ADC
2
ASTC_ECOLI
D:
[3-401]
--------
Q
P
---
I
T
R
E
N
F
D
E
W
M
I
P
V
---
Y
A
P
A
P
F
I
P
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
--
Q
A
S
K
F
W
H
T
G
-
N
G
---
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
---
A
T
--
F
---
A
D
--
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
R
-
Y
-
G
--
S
H
K
S
G
--
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
-
Q
D
F
-
A
P
L
P
A
D
I
R
H
A
A
Y
--------------
N
---------------------
D
I
N
S
A
S
A
L
I
------
D
-------------
D
-
S
T
C
A
V
I
V
E
P
I
-
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
L
L
A
T
E
E
C
A
R
V
M
T
--
V
G
T
------
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
N
A
D
-
Y
A
G
Q
A
K
Q
-
I
S
Q
E
A
A
-
K
A
-
G
V
M
V
L
I
A
G
G
-
N
V
V
-
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
-
10
PsiBlast_PDB
92.90
60%
-93
- C1 -
4ADC
2
ASTC_ECOLI
A:
[3-401]
--------
Q
P
---
I
T
R
E
N
F
D
E
W
M
I
P
V
---
Y
A
P
A
P
F
I
P
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
--
Q
A
S
K
F
W
H
T
G
-
N
G
---
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
---
A
T
--
F
---
A
D
--
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
R
-
Y
-
G
--
S
H
K
S
G
--
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
-
Q
D
F
-
A
P
L
P
A
D
I
R
H
A
A
Y
--------------
N
---------------------
D
I
N
S
A
S
A
L
I
------
D
-------------
D
-
S
T
C
A
V
I
V
E
P
I
-
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
L
L
A
T
E
E
C
A
R
V
M
T
--
V
G
T
------
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
N
A
D
-
Y
A
G
Q
A
K
Q
-
I
S
Q
E
A
A
-
K
A
-
G
V
M
V
L
I
A
G
G
-
N
V
V
-
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
-
32
PsiBlast_CBE
92.79
60%
-93
- C1 -
4ADC
3
ASTC_ECOLI
C:
[3-401]
--------
Q
P
---
I
T
R
E
N
F
D
E
W
M
I
P
V
---
Y
A
P
A
P
F
I
P
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
--
Q
A
S
K
F
W
H
T
G
-
N
G
---
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
---
A
T
--
F
---
A
D
--
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
R
-
Y
-
G
--
S
H
K
S
G
--
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
-
Q
D
F
-
A
P
L
P
A
D
I
R
H
A
A
Y
--------------
N
---------------------
D
I
N
S
A
S
A
L
I
------
D
-------------
D
-
S
T
C
A
V
I
V
E
P
I
-
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
L
L
A
T
E
E
C
A
R
V
M
T
--
V
G
T
------
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
N
A
D
-
Y
A
G
Q
A
K
Q
-
I
S
Q
E
A
A
-
K
A
-
G
V
M
V
L
I
A
G
G
-
N
V
V
-
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
-
30
PsiBlast_CBE
92.69
60%
-93
- C1 -
4ADD
4
ASTC_ECOLI
B:
[3-401]
--------
Q
P
---
I
T
R
E
N
F
D
E
W
M
I
P
V
---
Y
A
P
A
P
F
I
P
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
--
Q
A
S
K
F
W
H
T
G
-
N
G
---
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
---
A
T
--
F
---
A
D
--
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
R
-
Y
-
G
--
S
H
K
S
G
--
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
-
Q
D
F
-
A
P
L
P
A
D
I
R
H
A
A
Y
--------------
N
---------------------
D
I
N
S
A
S
A
L
I
------
D
-------------
D
-
S
T
C
A
V
I
V
E
P
I
-
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
L
L
A
T
E
E
C
A
R
V
M
T
--
V
G
T
------
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
N
A
D
-
Y
A
G
Q
A
K
Q
-
I
S
Q
E
A
A
-
K
A
-
G
V
M
V
L
I
A
G
G
-
N
V
V
-
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
-
28
PsiBlast_CBE
92.31
60%
-90
- C1 -
4ADD
4
ASTC_ECOLI
D:
[3-401]
--------
Q
P
---
I
T
R
E
N
F
D
E
W
M
I
P
V
---
Y
A
P
A
P
F
I
P
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
--
Q
A
S
K
F
W
H
T
G
-
N
G
---
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
---
A
T
--
F
---
A
D
--
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
R
-
Y
-
G
--
S
H
K
S
G
--
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
-
Q
D
F
-
A
P
L
P
A
D
I
R
H
A
A
Y
--------------
N
---------------------
D
I
N
S
A
S
A
L
I
------
D
-------------
D
-
S
T
C
A
V
I
V
E
P
I
-
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
L
L
A
T
E
E
C
A
R
V
M
T
--
V
G
T
------
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
N
A
D
-
Y
A
G
Q
A
K
Q
-
I
S
Q
E
A
A
-
K
A
-
G
V
M
V
L
I
A
G
G
-
N
V
V
-
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
-
34
PsiBlast_CBE
92.25
60%
-93
- C1 -
4ADB
3
ASTC_ECOLI
D:
[3-401]
--------
Q
P
---
I
T
R
E
N
F
D
E
W
M
I
P
V
---
Y
A
P
A
P
F
I
P
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
--
Q
A
S
K
F
W
H
T
G
-
N
G
---
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
---
A
T
--
F
---
A
D
--
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
R
-
Y
-
G
--
S
H
K
S
G
--
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
-
Q
D
F
-
A
P
L
P
A
D
I
R
H
A
A
Y
--------------
N
---------------------
D
I
N
S
A
S
A
L
I
------
D
-------------
D
-
S
T
C
A
V
I
V
E
P
I
-
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
L
L
A
T
E
E
C
A
R
V
M
T
--
V
G
T
------
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
N
A
D
-
Y
A
G
Q
A
K
Q
-
I
S
Q
E
A
A
-
K
A
-
G
V
M
V
L
I
A
G
G
-
N
V
V
-
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
-
11
PsiBlast_PDB
92.18
60%
-90
- C1 -
4ADD
4
ASTC_ECOLI
A:
[3-401]
--------
Q
P
---
I
T
R
E
N
F
D
E
W
M
I
P
V
---
Y
A
P
A
P
F
I
P
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
--
Q
A
S
K
F
W
H
T
G
-
N
G
---
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
---
A
T
--
F
---
A
D
--
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
R
-
Y
-
G
--
S
H
K
S
G
--
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
-
Q
D
F
-
A
P
L
P
A
D
I
R
H
A
A
Y
--------------
N
---------------------
D
I
N
S
A
S
A
L
I
------
D
-------------
D
-
S
T
C
A
V
I
V
E
P
I
-
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
L
L
A
T
E
E
C
A
R
V
M
T
--
V
G
T
------
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
N
A
D
-
Y
A
G
Q
A
K
Q
-
I
S
Q
E
A
A
-
K
A
-
G
V
M
V
L
I
A
G
G
-
N
V
V
-
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
-
2
PsiBlast_PDB
91.70
65%
-94
- C1 -
2PB2
6
ARGD_SALTY
A:
[39-419]
--------------------------------
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
--
Q
G
E
T
L
W
H
T
S
-
N
V
---
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
---
A
T
--
F
---
A
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
-
H
-
S
--
P
F
K
T
K
--
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
-
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
--------------
N
---------------------
D
L
H
A
V
K
A
V
M
------
D
-------------
D
-
H
T
C
A
V
V
V
E
P
I
-
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
------------
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
-
Y
K
G
R
A
R
D
-
F
L
Y
A
G
A
-
E
A
-
G
V
M
V
L
N
A
G
A
-
D
V
M
-
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
A
-
29
PsiBlast_CBE
91.43
60%
-91
- C1 -
4ADD
4
ASTC_ECOLI
C:
[3-401]
--------
Q
P
---
I
T
R
E
N
F
D
E
W
M
I
P
V
---
Y
A
P
A
P
F
I
P
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
--
Q
A
S
K
F
W
H
T
G
-
N
G
---
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
---
A
T
--
F
---
A
D
--
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
R
-
Y
-
G
--
S
H
K
S
G
--
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
-
Q
D
F
-
A
P
L
P
A
D
I
R
H
A
A
Y
--------------
N
---------------------
D
I
N
S
A
S
A
L
I
------
D
-------------
D
-
S
T
C
A
V
I
V
E
P
I
-
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
L
L
A
T
E
E
C
A
R
V
M
T
--
V
G
T
------
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
N
A
D
-
Y
A
G
Q
A
K
Q
-
I
S
Q
E
A
A
-
K
A
-
G
V
M
V
L
I
A
G
G
-
N
V
V
-
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
-
4
PsiBlast_PDB
91.34
65%
-92
- C1 -
4JEV
4
ARGD_SALTY
A:
[22-419]
------------
A
I
T
R
A
T
F
D
E
V
I
L
P
V
---
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
--
Q
G
E
T
L
W
H
T
S
-
N
V
---
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
---
A
T
--
F
---
A
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
-
H
-
S
--
P
F
K
T
K
--
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
-
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
--------------
N
---------------------
D
L
H
A
V
K
A
V
M
------
D
-------------
D
-
H
T
C
A
V
V
V
E
P
I
-
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
H
--
V
G
S
------
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
-
Y
K
G
R
A
R
D
-
F
L
Y
A
G
A
-
E
A
-
G
V
M
V
L
N
A
G
A
-
D
V
M
-
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
A
L
9
PsiBlast_PDB
91.09
60%
-90
- C1 -
4ADB
4
ASTC_ECOLI
A:
[3-401]
--------
Q
P
---
I
T
R
E
N
F
D
E
W
M
I
P
V
---
Y
A
P
A
P
F
I
P
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
--
Q
A
S
K
F
W
H
T
G
-
N
G
---
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
---
A
T
--
F
---
A
D
--
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
R
-
Y
-
G
--
S
H
K
S
G
--
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
-
Q
D
F
-
A
P
L
P
A
D
I
R
H
A
A
Y
--------------
N
---------------------
D
I
N
S
A
S
A
L
I
------
D
-------------
D
-
S
T
C
A
V
I
V
E
P
I
-
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
L
L
A
T
E
E
C
A
R
V
M
T
--
V
G
T
------
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
N
A
D
-
Y
A
G
Q
A
K
Q
-
I
S
Q
E
A
A
-
K
A
-
G
V
M
V
L
I
A
G
G
-
N
V
V
-
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
-
24
PsiBlast_CBE
90.66
65%
-92
- C1 -
4JF1
9
ARGD_SALTY
B:
[33-419]
-----------------------
L
P
V
---
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
--
Q
G
E
T
L
W
H
T
S
-
N
V
---
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
---
A
T
--
F
---
A
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
-
H
-
S
--
P
F
K
T
K
--
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
-
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
--------------
N
---------------------
D
L
H
A
V
K
A
V
M
------
D
-------------
D
-
H
T
C
A
V
V
V
E
P
I
-
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
H
--
V
G
S
------
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
-
Y
K
G
R
A
R
D
-
F
L
Y
A
G
A
-
E
A
-
G
V
M
V
L
N
A
G
A
-
D
V
M
-
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
--
8
PsiBlast_PDB
90.64
65%
-96
- C1 -
4JEX
17
ARGD_SALTY
A:
[39-419]
--------------------------------
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
--
Q
G
E
T
L
W
H
T
S
-
N
V
---
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
---
A
T
--
F
---
A
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
-
H
-
S
--
P
F
K
T
K
--
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
-
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
--------------
N
---------------------
D
L
H
A
V
K
A
V
M
------
D
-------------
D
-
H
T
C
A
V
V
V
E
P
I
-
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
-------------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
-
Y
K
G
R
A
R
D
-
F
L
Y
A
G
A
-
E
A
-
G
V
M
V
L
N
A
G
A
-
D
V
M
-
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
A
L
27
PsiBlast_CBE
90.24
65%
-93
- C1 -
4JEX
17
ARGD_SALTY
B:
[33-419]
-----------------------
L
P
V
---
K
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
--
Q
G
E
T
L
W
H
T
S
-
N
V
---
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
---
A
T
--
F
---
A
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
-
H
-
S
--
P
F
K
T
K
--
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
-
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
--------------
N
---------------------
D
L
H
A
V
K
A
V
M
------
D
-------------
D
-
H
T
C
A
V
V
V
E
P
I
-
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
-------------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
-
Y
K
G
R
A
R
D
-
F
L
Y
A
G
A
-
E
A
-
G
V
M
V
L
N
A
G
A
-
D
V
M
-
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
A
-
23
PsiBlast_CBE
90.06
65%
-92
- C1 -
4JEW
13
ARGD_SALTY
B:
[31-419]
---------------------
V
I
L
P
V
---
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
--
Q
G
E
T
L
W
H
T
S
-
N
V
---
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
---
A
T
--
F
---
A
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
-
H
-
S
--
P
F
K
T
K
--
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
-
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
--------------
N
---------------------
D
L
H
A
V
K
A
V
M
------
D
-------------
D
-
H
T
C
A
V
V
V
E
P
I
-
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
H
--
V
G
S
------
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
-
Y
K
G
R
A
R
D
-
F
L
Y
A
G
A
-
E
A
-
G
V
M
V
L
N
A
G
A
-
D
V
M
-
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
--
25
PsiBlast_CBE
89.49
65%
-92
- C1 -
4JEY
13
ARGD_SALTY
B:
[33-419]
-----------------------
L
P
V
---
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
--
Q
G
E
T
L
W
H
T
S
-
N
V
---
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
---
A
T
--
F
---
A
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
-
H
-
S
--
P
F
K
T
K
--
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
-
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
--------------
N
---------------------
D
L
H
A
V
K
A
V
M
------
D
-------------
D
-
H
T
C
A
V
V
V
E
P
I
-
Q
G
A
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
H
--
V
G
S
------
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
-
Y
K
G
R
A
R
D
-
F
L
Y
A
G
A
-
E
A
-
G
V
M
V
L
N
A
G
A
-
D
V
M
-
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
A
-
26
PsiBlast_CBE
89.14
65%
-93
- C1 -
4JEZ
13
ARGD_SALTY
B:
[33-419]
-----------------------
L
P
V
---
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
--
Q
G
E
T
L
W
H
T
S
-
R
V
---
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
---
A
T
--
F
---
A
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
-
H
-
S
--
P
F
K
T
K
--
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
-
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
--------------
N
---------------------
D
L
H
A
V
K
A
V
M
------
D
-------------
D
-
H
T
C
A
V
V
V
E
P
I
-
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
-------------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
-
Y
K
G
R
A
R
D
-
F
L
Y
A
G
A
-
E
A
-
G
V
M
V
L
N
A
G
A
-
D
V
M
-
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
A
-
21
PsiBlast_CBE
88.56
65%
-93
- C1 -
2PB2
5
ARGD_SALTY
B:
[33-419]
-----------------------
L
P
V
---
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
--
Q
G
E
T
L
W
H
T
S
-
N
V
---
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
---
A
T
--
F
---
A
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
-
H
-
S
--
P
F
K
T
K
--
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
-
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
--------------
N
---------------------
D
L
H
A
V
K
A
V
M
------
D
-------------
D
-
H
T
C
A
V
V
V
E
P
I
-
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
--------------
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
-
Y
K
G
R
A
R
D
-
F
L
Y
A
G
A
-
E
A
-
G
V
M
V
L
N
A
G
A
-
D
V
M
-
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
A
-
109
HHSearch
73.94
43%
-88
- C1 -
2ORD
15
ARGD_THEMA
A:
[14-396]
---------------------
Y
L
M
N
T
---
Y
S
R
F
P
A
T
F
V
Y
G
K
G
S
W
I
Y
D
E
K
G
N
A
Y
L
D
F
T
S
G
I
A
V
N
V
L
G
H
-
S
H
P
R
L
V
E
A
I
K
D
--
Q
A
E
K
L
I
H
C
S
-
N
L
---
F
W
N
R
P
Q
M
E
L
A
E
L
L
S
K
---
N
T
--
F
---
G
G
--
K
V
F
F
A
N
T
G
T
E
A
N
E
A
A
I
K
I
A
R
K
Y
G
-
K
K
-
K
-
S
--
E
K
K
Y
R
--
I
L
S
A
H
N
S
F
H
G
R
T
L
G
S
L
T
A
T
G
Q
P
K
Y
Q
-
K
P
F
-
E
P
L
V
P
G
F
E
Y
F
E
F
--------------
N
---------------------
N
V
E
D
L
R
R
K
M
------
S
-------------
E
-
D
V
C
A
V
F
L
E
P
I
Q
G
E
S
G
I
V
P
A
-
T
K
E
F
L
E
E
A
R
K
L
C
D
E
Y
D
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
K
L
F
A
Y
Q
K
Y
G
V
V
P
D
V
L
T
T
A
K
G
L
G
G
G
-
V
-
P
I
G
A
V
I
V
N
E
R
A
N
-
V
L
E
--
P
G
D
------
H
G
T
T
F
G
G
N
P
L
A
C
R
A
G
V
T
V
I
K
E
L
T
K
E
G
F
L
E
E
V
E
E
K
G
N
Y
L
M
K
K
L
Q
E
M
K
E
E
Y
D
V
V
A
D
V
R
G
M
G
L
M
I
G
I
Q
F
R
E
E
---
V
S
N
R
E
-
V
A
T
K
C
F
-
E
N
-
K
L
L
V
V
P
A
G
N
-
N
T
I
-
R
F
L
P
P
L
T
V
E
Y
G
E
I
D
L
A
V
E
T
L
K
K
V
L
Q
G
I
---
62
PsiBlast_CBE
70.42
34%
-87
- C1 -
2OAT
2
OAT_HUMAN
A:
[49-436]
--------------------
K
Y
G
A
H
N
---
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
--
Q
V
D
K
L
T
L
T
S
-
R
A
---
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
---
L
F
--
N
---
Y
H
--
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
-
K
-
G
--
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
-
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
--------------
N
---------------------
D
L
P
A
L
E
R
A
L
------
Q
-------------
D
P
N
V
A
A
F
M
V
E
P
I
-
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
--
P
G
E
------
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
L
P
S
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
K
E
T
-
K
D
W
D
A
W
K
-
V
C
L
R
L
R
-
D
N
-
G
L
L
A
K
P
T
H
G
-
D
I
I
-
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
L
S
F
---
47
PsiBlast_CBE
70.03
34%
-85
- C1 -
2BYJ
2
OAT_HUMAN
A:
[49-436]
--------------------
K
Y
G
A
H
N
---
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
--
Q
V
D
K
L
T
L
T
S
-
R
A
---
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
---
L
F
--
N
---
Y
H
--
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
-
K
-
G
--
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
-
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
--------------
N
---------------------
D
L
P
A
L
E
R
A
L
------
Q
-------------
D
P
N
V
A
A
F
M
V
E
P
I
-
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
--
P
G
E
------
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
L
P
S
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
K
E
T
-
K
D
W
D
A
W
K
-
V
C
L
R
L
R
-
D
N
-
G
L
L
A
K
P
T
H
G
-
D
I
I
-
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
L
S
F
---
45
PsiBlast_CBE
68.56
34%
-85
- C1 -
2BYJ
1
OAT_HUMAN
C:
[49-436]
--------------------
K
Y
G
A
H
N
---
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
--
Q
V
D
K
L
T
L
T
S
-
R
A
---
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
---
L
F
--
N
---
Y
H
--
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
-
K
-
G
--
I
Q
K
Y
K
AK
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
-
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
--------------
N
---------------------
D
L
P
A
L
E
R
A
L
------
Q
-------------
D
P
N
V
A
A
F
M
V
E
P
I
-
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
--
P
G
E
------
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
L
P
S
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
K
E
T
-
K
D
W
D
A
W
K
-
V
C
L
R
L
R
-
D
N
-
G
L
L
A
K
P
T
H
G
-
D
I
I
-
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
L
S
F
---
102
HHSearch
68.54
33%
-83
- C1 -
2OAT
2
OAT_HUMAN
A:
[40-438]
-----------
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
---
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
--
Q
V
D
K
L
T
L
T
S
-
R
A
---
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
---
L
F
--
N
---
Y
H
--
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
Q
--
K
Y
K
A
K
--
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
-
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
--------------
N
---------------------
D
L
P
A
L
E
R
A
L
------
Q
D------------
P
-
N
V
A
A
F
M
V
E
P
I
-
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
--
P
G
E
------
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
L
P
S
--
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
K
E
T
-
K
D
W
D
A
W
K
-
V
C
L
R
L
R
-
D
N
-
G
L
L
A
K
P
T
H
G
-
D
I
I
-
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
L
S
F
---
40
PsiBlast_CBE
68.50
43%
-90
- C1 -
1VEF
2
ARGD_THET8
B:
[32-390]
-------------------------------------
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
--
Q
A
E
T
L
M
A
M
P
-
Q
T
---
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
---
I
L
--
P
---
P
E
LN
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
------
G
--
R
K
K
F
----
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
R
-
E
P
F
-
L
P
L
V
E
P
V
E
F
I
P
Y
--------------
N
---------------------
D
V
E
A
L
K
R
A
V
------
D
-------------
E
-
E
T
A
A
V
I
L
E
P
V
-
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
--
K
G
G
------
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
P
K
--
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
-----
K
E
K
A
A
P
-
Y
I
A
R
L
E
-
K
E
H
R
V
L
A
L
Q
A
G
P
-
T
V
I
-
R
F
L
P
P
L
V
I
E
----
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
A
-
124
Fugue
68.22
32%
-87
- C1 -
2OAT
2
OAT_HUMAN
A:
[36-439]
GPPT
S
D
--
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
--------
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
---
S
Q
V
D
K
L
--
T
-
L
T
SRA
F
Y
N
N
V
L
G
E
Y
E
E
-
Y
I
T
---
K
L
--
F
N--
Y
H
--
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
-
K
-
G
IQ
K
Y
K
A
K
--
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
-Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
ND
L
P
A
L
E
-------
R
---------------------
A
L
Q
D
P
--------------------------
N
V
A
A
F
M
V
E
P
I
-
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
PG--
E
------
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
L
P
S
--
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
K
E
T
K-
D
W
D
A
W
K
-
V
C
L
R
L
R
-
D
N
-
G
L
L
A
K
P
T
H
-G
D
I
I
-
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
L
S
F
---
46
PsiBlast_CBE
68.10
34%
-85
- C1 -
2BYJ
2
OAT_HUMAN
B:
[49-436]
--------------------
K
Y
G
A
H
N
---
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
--
Q
V
D
K
L
T
L
T
S
-
R
A
---
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
---
L
F
--
N
---
Y
H
--
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
-
K
-
G
--
I
Q
K
Y
K
AK
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
-
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
--------------
N
---------------------
D
L
P
A
L
E
R
A
L
------
Q
-------------
D
P
N
V
A
A
F
M
V
E
P
I
-
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
--
P
G
E
------
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
L
P
S
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
K
E
T
-
K
D
W
D
A
W
K
-
V
C
L
R
L
R
-
D
N
-
G
L
L
A
K
P
T
H
G
-
D
I
I
-
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
L
S
F
---
104
HHSearch
67.19
41%
-85
- C1 -
1VEF
2
ARGD_THET8
A:
[21-395]
-----------------------
S
G
V
---
Y
N
K
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
--
Q
A
E
T
L
M
A
M
P
-
Q
T
---
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
---
I
L
PP
E
---
L
N
--
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
----------
T
G
R
K
K
--
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
R
-
E
P
F
-
L
P
L
V
E
P
V
E
F
I
P
Y
--------------
N
---------------------
D
V
E
A
L
K
R
A
V
------
D
-------------
E
-
E
T
A
A
V
I
L
E
P
V
-
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
--
K
G
G
------
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
P
--
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
K
E
K
-----
A
A
P
-
Y
I
A
R
L
E
K
E
H
-
R
V
L
A
L
Q
A
G
P
-
T
V
I
-
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
A
-----
122
HHSearch
66.59
38%
-85
- C1 -
2EH6
2
ARGD_AQUAE
A:
[2-375]
---------------------
Y
L
M
N
N
---
Y
A
R
L
P
V
K
F
V
R
G
K
G
V
Y
L
Y
D
E
E
G
K
E
Y
L
D
F
V
S
G
I
G
V
N
S
L
G
H
-
A
Y
P
K
L
T
E
A
L
K
E
--
Q
V
E
K
L
L
H
V
S
-
N
L
---
Y
E
N
P
W
Q
E
E
L
A
H
K
L
V
K
---
H
F
--
W
T
--
E
G
--
K
V
F
F
A
N
S
G
T
E
S
V
E
A
A
I
K
L
A
R
K
Y
W
R
D
K
-
G
----
K
N
K
W
K
--
F
I
S
F
E
N
S
F
H
G
R
T
Y
G
S
L
S
A
T
G
Q
P
K
F
H
-
K
G
F
-
E
P
L
V
P
G
F
S
Y
A
K
L
--------------
N
---------------------
D
I
D
S
V
Y
K
L
L
------
D
-------------
E
-
E
T
A
G
I
I
I
E
V
I
Q
G
E
G
G
V
N
E
A
-
S
E
D
F
L
S
K
L
Q
E
I
C
K
E
K
D
V
L
L
I
I
D
E
V
Q
T
G
I
G
R
T
G
E
F
Y
A
Y
Q
H
F
N
L
K
P
D
V
I
A
L
A
K
G
L
G
G
G
-
V
-
P
I
G
A
I
L
A
R
E
E
V
A
Q
S
F
T
--
P
G
S
------
H
G
S
T
F
G
G
N
P
L
A
C
R
A
G
T
V
V
V
D
E
V
--
E
K
L
L
P
H
V
R
E
V
G
N
Y
F
K
E
K
L
K
E
L
G
K
-----
G
K
V
K
G
R
G
L
M
L
G
L
E
L
E
R
-----
E
C
K
D
-
Y
V
L
K
A
L
-
E
K
-
G
L
L
I
N
C
T
A
G
-
K
V
L
-
R
F
L
P
P
L
I
I
Q
K
E
H
I
D
R
A
I
S
V
L
R
E
I
L
------
38
PsiBlast_CBE
66.56
43%
-86
- C1 -
1WKH
2
ARGD_THET8
B:
[32-390]
-------------------------------------
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
--
Q
A
E
T
L
M
A
M
P
-
Q
T
---
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
---
I
L
--
P
---
P
E
LN
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
------
G
--
R
K
K
F
----
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
R
-
E
P
F
-
L
P
L
V
E
P
V
E
F
I
P
Y
--------------
N
---------------------
D
V
E
A
L
K
R
A
V
------
D
-------------
E
-
E
T
A
A
V
I
L
E
P
V
-
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
--
K
G
G
------
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
P
K
--
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
-----
K
E
K
A
A
P
-
Y
I
A
R
L
E
-
K
E
H
R
V
L
A
L
Q
A
G
P
-
T
V
I
-
R
F
L
P
P
L
V
I
E
----
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
A
-
39
PsiBlast_CBE
66.17
43%
-87
- C1 -
1WKG
2
ARGD_THET8
B:
[32-390]
-------------------------------------
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
--
Q
A
E
T
L
M
A
M
P
-
Q
T
---
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
---
I
L
--
P
---
P
E
LN
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
------
G
--
R
K
K
F
----
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
R
-
E
P
F
-
L
P
L
V
E
P
V
E
F
I
P
Y
--------------
N
---------------------
D
V
E
A
L
K
R
A
V
------
D
-------------
E
-
E
T
A
A
V
I
L
E
P
V
-
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
--
K
G
G
------
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
P
K
--
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
-----
K
E
K
A
A
P
-
Y
I
A
R
L
E
-
K
E
H
R
V
L
A
L
Q
A
G
P
-
T
V
I
-
R
F
L
P
P
L
V
I
E
----
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
A
-
37
PsiBlast_CBE
65.06
40%
-86
- C1 -
2EH6
2
ARGD_AQUAE
B:
[2-368]
---------------------
Y
L
M
N
N
---
Y
A
R
L
P
V
K
F
V
R
G
K
G
V
Y
L
Y
D
E
E
G
K
E
Y
L
D
F
V
S
G
I
G
V
N
S
L
G
H
-
A
Y
P
K
L
T
E
A
L
K
E
--
Q
V
E
K
L
L
H
V
S
-
N
L
---
Y
E
N
P
W
Q
E
E
L
A
H
K
L
V
K
---
H
F
--
W
---
T
E
G-
K
V
F
F
A
N
S
G
T
E
S
V
E
A
A
I
K
L
A
R
K
Y
W
R
D
--
K
-
G
--
K
N
K
W
K
--
F
I
S
F
E
N
S
F
H
G
R
T
Y
G
S
L
S
A
T
G
Q
P
K
F
H
-
K
G
F
-
E
P
L
V
P
G
F
S
Y
A
K
L
--------------
N
---------------------
D
I
D
S
V
Y
K
L
L
------
D
-------------
E
-
E
T
A
G
I
I
I
E
V
I
-
Q
G
E
G
G
V
N
E
A
S
E
D
F
L
S
K
L
Q
E
I
C
K
E
K
D
V
L
L
I
I
D
E
V
Q
T
G
I
G
R
T
G
E
F
Y
A
Y
Q
H
F
N
L
K
P
D
V
I
A
L
A
K
G
L
G
G
G
-
V
-
P
I
G
A
I
L
A
R
E
E
V
A
Q
S
F
T
--
P
G
S
------
H
G
S
T
F
G
G
N
P
L
A
C
R
A
G
T
V
V
V
D
E
V
E
--
K
L
L
P
H
V
R
E
V
G
N
Y
F
K
E
K
L
K
E
L
G
K
-----
G
K
V
K
G
R
G
L
M
L
G
L
E
L
E
R
E
-
C
K
D
Y
----
V
L
K
A
L
E
-
K
--
G
L
L
I
N
C
T
A
G
-
K
V
L
-
R
F
L
P
P
L
I
I
Q
K
E
H
I
D
R
A
I
S
V
L
R
E
I
L
------
97
PsiBlast_CBE
61.14
33%
-88
- C1 -
2EO5
3
?
A:
[31-418]
---------------------------------------
G
E
G
V
W
I
Y
D
V
D
G
N
K
Y
L
D
F
T
S
G
I
G
V
N
N
L
G
W
P
S
H
P
E
V
I
K
I
G
I
E
--
Q
M
Q
K
L
A
H
A
A
A
N
D
---
F
Y
N
I
P
Q
L
E
L
A
K
K
L
V
T
Y
SP
G
N
--
F
---
Q
K
--
K
V
F
F
S
N
S
G
T
E
A
I
E
A
S
I
K
V
V
K
N
T
G
----------
R
K
Y
---
I
I
A
F
L
G
G
F
H
G
R
T
F
G
S
I
S
L
T
A
S
K
A
V
Q
-
R
S
I
V
G
P
F
M
P
G
V
I
H
V
P
Y
PNPYRNPWHINGYE
N
---------------------
P
S
E
L
V
N
R
V
I
------
E
F
I
E
DYIFVNLVPP
E
-
E
V
A
G
I
F
F
E
P
I
-
Q
G
E
G
G
Y
V
I
P
P
K
N
F
F
A
E
L
Q
K
L
A
K
K
Y
G
I
L
L
V
D
D
E
V
Q
M
G
L
G
R
T
G
K
L
F
A
I
E
N
F
N
T
V
P
D
V
I
T
L
A
K
A
L
G
G
G
I
M
-
P
I
G
A
T
I
F
R
K
D
L
--
D
F
K
--------------
T
F
G
G
N
A
L
A
C
A
I
G
S
K
V
I
D
I
V
K
--
D
L
L
P
H
V
N
E
I
G
K
I
F
A
E
E
L
Q
------
G
L
A
D
D
V
R
G
I
G
L
A
W
G
L
E
Y
N
E
K
----
K
V
R
D
R
I
I
G
E
S
F
-
K
R
-
G
L
L
L
L
P
A
G
R
-
S
A
I
-
R
V
I
P
P
L
V
I
S
E
E
E
A
K
Q
G
L
D
I
L
K
K
-
V
I
K
V
V
--
120
HHSearch
60.03
34%
-85
- C1 -
2EO5
3
?
A:
[10-418]
------------------
S
D
I
Y
L
A
T
S
T
R
D
P
E
L
F
P
L
V
I
D
H
G
E
G
V
W
I
Y
D
V
D
G
N
K
Y
L
D
F
T
S
G
I
G
V
N
N
L
G
W
P
S
H
P
E
V
I
K
I
G
I
E
--
Q
M
Q
K
L
A
H
A
A
A
N
D
---
F
Y
N
I
P
Q
L
E
L
A
K
K
L
V
T
---
Y
S
--
P
GN
F
Q
K
--
K
V
F
F
S
N
S
G
T
E
A
I
E
A
S
I
K
V
V
K
N
-----------
T
G
R
K
Y
--
I
I
A
F
L
G
G
F
H
G
R
T
F
G
S
I
S
L
T
A
S
K
A
V
Q
R
S
I
V
-
G
P
F
M
P
G
V
I
H
V
P
Y
--------------
P
NPYRNPWHINGYEN
P
S
E
L
V
N
R
V
I
E
F
I
E
D
Y
I
FVNLVP
P
-------------
E
-
E
V
A
G
I
F
F
E
P
I
-
Q
G
E
G
G
Y
V
I
P
P
K
N
F
F
A
E
L
Q
K
L
A
K
K
Y
G
I
L
L
V
D
D
E
V
Q
M
G
L
G
R
T
G
K
L
F
A
I
E
N
F
N
T
V
P
D
V
I
T
L
A
K
A
L
G
G
G
I
M
-
P
I
G
A
T
I
F
R
K
D
L
D
--
F
K
--------------
T
F
G
G
N
A
L
A
C
A
I
G
S
K
V
I
D
I
V
K
--
D
L
L
P
H
V
N
E
I
G
K
I
F
A
E
E
L
Q
G
L
A
------
D
D
V
R
G
I
G
L
A
W
G
L
E
Y
N
E
K
---
K
V
R
D
R
-
I
I
G
E
S
F
-
K
R
-
G
L
L
L
L
P
A
G
R
-
S
A
I
-
R
V
I
P
P
L
V
I
S
E
E
E
A
K
Q
G
L
D
I
L
K
K
V
I
K
V
V
---
99
PsiBlast_CBE
46.66
33%
-82
- C1 -
4PPM
3
?
A:
[424-794]
-----------------------------------------
G
T
Q
L
Y
D
D
A
G
E
A
F
L
D
M
V
A
G
Y
G
C
L
N
L
G
H
-
N
P
Q
P
V
V
N
A
L
K
N
Y
L
D
A
Q
G
P
N
F
I
Q
-
Y
I
---
S
I
P
E
Q
T
A
K
L
A
E
V
L
C
R
---
L
A
--
P
---
G
N
MG
R
V
F
F
S
N
S
G
T
E
A
V
E
A
A
M
K
I
A
K
A
S
T
G
----------
K
P
G
--
I
A
Y
L
R
N
S
Y
H
G
K
T
L
G
A
L
S
I
T
G
R
D
K
H
R
-
R
Y
F
-
T
P
L
L
D
A
M
V
E
V
P
F
--------------
G
---------------------
D
L
A
A
L
R
E
A
L
------
N
R------------
E
-
D
V
G
A
L
M
I
E
P
I
-
Q
G
E
G
G
V
H
I
P
P
A
G
Y
L
Q
A
V
Q
Q
L
C
R
E
T
G
V
L
L
M
V
D
E
V
Q
T
G
L
G
R
T
G
K
L
F
A
C
E
W
D
G
I
E
P
D
V
L
M
L
S
K
S
L
S
G
G
-
L
I
P
I
G
A
T
L
C
R
A
D
L
W
Q
K
-
A
--
Y
G
T
ADRFLV
H
S
S
T
Y
G
G
G
N
L
A
S
V
V
A
L
S
A
L
R
E
I
L
A
Q
D
L
V
G
H
A
E
R
M
G
A
Y
F
K
Q
A
L
S
E
I
A
A
R
Y
P
F
V
S
E
V
R
G
R
G
L
M
L
G
I
Q
F
D
Q
A
-----------------------------
H
T
T
W
K
F
L
P
D
P
V
--
Q
A
H
L
R
A
A
M
D
R
M
E
Q
A
L
G
E
M
---
98
PsiBlast_CBE
46.13
33%
-84
- C1 -
4PPM
3
?
B:
[424-794]
-----------------------------------------
G
T
Q
L
Y
D
D
A
G
E
A
F
L
D
M
V
A
G
Y
G
C
L
N
L
G
H
-
N
P
Q
P
V
V
N
A
L
K
N
YL
D
A
Q
G
P
N
F
I
Q
-
Y
I
---
S
I
P
E
Q
T
A
K
L
A
E
V
L
C
R
---
L
A
--
P
---
G
N
MG
R
V
F
F
S
N
S
G
T
E
A
V
E
A
A
M
K
I
A
K
A
S
T
G
----------
K
P
G
--
I
A
Y
L
R
N
S
Y
H
G
K
T
L
G
A
L
S
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T
G
R
D
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H
R
-
R
Y
F
-
T
P
L
L
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V
E
V
P
F
--------------
G
---------------------
D
L
A
A
L
R
E
A
L
------
N
R------------
E
-
D
V
G
A
L
M
I
E
P
I
-
Q
G
E
G
G
V
H
I
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Y
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L
C
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V
L
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G
R
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A
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P
D
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L
M
L
S
K
S
L
S
G
G
-
L
I
P
I
G
A
T
L
C
R
A
D
L
W
Q
K
-
A
--
Y
G
T
ADRFLV
H
S
S
T
Y
G
G
G
N
L
A
S
V
V
A
L
S
A
L
R
E
I
L
A
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D
L
V
G
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A
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M
G
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A
A
R
Y
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V
S
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V
R
G
R
G
L
M
L
G
I
Q
F
D
-----------------------------
W
-
H
T
T
W
K
F
L
P
D
P
V
--
Q
A
H
L
R
A
A
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M
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G
E
M
---