@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0903: (2016-01-24 )
MKSAEIREAFLRFFEEKGHTRVASSSLIPANDPTLLFTNAGMNQFKDCFLGLEKRAYTRATTSQKCVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKRDAIHYAWEFLTGEKWLNLPKEKLWVTVYATDDEAYDIWTKEVGVPAERMVRIGDNKGAPYASDNFWAMGDTGPCGPCTEIFFDHGPEIWGGPPGSPEEDGDRYIEIWNNVFMQFNRTADGVMHPLPAPSVDTGMGLERVSAVLQHVHSNYEIDLFQNLLKASAEAIGCANDDAPSLKVVADHIRSCSFLIADGVLPSNEGRGYVLRRIIRRACRHGNKLGARGTFFHKIVAALVAEMGDAFPELKQQQAHIERVLKTEEEQFAKTLEQGLKILEQDLAELQGSVIPGNVVFKLYDTYGFPVDLTNDIARERELTIDEDGFEREMEAQRERARASSAFGMDYNSLVKVDGETRFLGYQGVSGAGQIVALFRDGQAVERLEEGEEGVVVLDQTPFYAESGGQVGDSGYLEAAGVRFDVRDTTKAGGAHLHHGVVARGNLSVGGAVKAEVDASVRQATALNHSATHLLHAALRQVLGDHVQQKGSLVDSQRLRFDFSHFEAIKAEQLKALEDIVNAEIRRNTEVETEETDIDTAKAKGAMALFGEKYGDQVRVLSMGGDFSVELCGGTHVSRTGDIGLFKITSEGGVAAGVRRIEAVTGAAALAYLNGAEEQLKEAASLVKGSRDNLLDKLGALLERNRSLEKELEQLKAKAASAAGDDLSAAAVEIKGAKVLAARLDGLDGKALLALVDQLKNKLGRAVILLGGELDGKVVLVAGVTQDLTGQLKAGELMKQAAAAVGGKGGGRPDMAQGGGTDAAKLDEALALAQRFVEQGL
Atome Classification :
(23 SA)
.........10........20........30........40........50.-........60........70........80........90........-----100.......110.......120.......130.......140.......150.......160.......170.....--------..180.......190.......200.......210.---------......220.-------......230.......---------240------.......250.......260.----......270----.---------------------------------------------------..-----....280-........290.......300.......310.......320.......330.......340.......350.......360.......370.....---..380.---......390.......400.......410.......420-.-.......430.......440..---.....450.......460.---......470-.........480......----.490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640..--...-...650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820..-.....830.......840.......850.......860.......870..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
S
A
E
I
R
E
A
F
L
R
F
F
E
EKGHTRVASSSLIPAND
P
T
L
L
F
TNA
G
M
N
Q
F
K
D
C
F
L
-
G
-
L
E
K
RAYTRAT
T
S
Q
K
C
V
R
AGGKHN
D
L
E
NVGY
T
A
R
H
H
T
F
F
E
M
LGNFS
F
G
D
-----
Y
F
K
R
D
A
I
H
Y
A
W
E
F
LT
G
E
K
W
LNLP
K
E
K
L
W
V
T
V
Y
ATDDE
A
Y
D
I
W
T
K
EVGV
P
A
E
R
M
V
R
IGDNKGAPYASDN
F
W
AMGDTGPC--------G
P
C
T
E
I
F
FDHGPEIWGGPPGSPEEDG
D
R
Y
I
E
I
W
N
N
V
---------
F
M
QFNRTADG-------VMHPLPAPSVDTGM
G
L
---------
E
R
V
------
S
A
V
L
Q
H
V
HSNY
E
I
D
L
F
Q
N
L
L
K
----
A
S
A
E
AIGCA----N---------------------------------------------------DD-----AP
S
L
K
V
--
V
A
D
H
I
R
S
C
S
F
L
IADGVLPSNEG
R
G
Y
V
L
R
R
I
I
R
R
A
C
RHGNKLGAR
G
T
F
F
H
K
I
V
A
A
L
V
A
E
M
G
D
A
F
P
E
L
K
Q
Q
Q
A
H
I
E
R
V
L
K
T
E
E
E
Q
F
A
K
T
L
E
Q
G
L
K
I
L
E
---
Q
D
L
A
E
L---QGSVIPG
N
V
V
F
K
L
YDTYGFPVD
L
T
N
D
I
A
R
ERELTIDED--G-
F
E
R
E
M
E
A
Q
R
E
R
ARASSAFGMD
Y
---
N
S
L
V
K
VDGE
T
R
F
L
G
YQGVS---GA
G
Q
I
V
A
---
L
FRD
G
Q
A
V
E
R
L
EEGEE
G
V
----
V
V
L
DQTPFYAESGGQVGDSG
Y
L
E
AA
G
V
R
F
D
VRDTTKAGGAHLH
H
G
V
V
ARGNLSVG
G
A
V
K
A
E
V
D
A
S
V
R
Q
A
TALN
H
S
A
T
H
L
L
H
A
A
L
R
Q
V
L
G
D
H
V
Q
Q
KGSLVD
S
Q
R
L
R
F
D
F
S
H
F
E
A
I
K
A
E
Q
L
K
A
L
E
D
I
V
N
A
E
I
RRNTEVETEETDID
T
A
KAK
G
A
M
-
A
L
F
--
G
EK-YG
D
Q
V
R
V
L
SMGG
D
F
S
V
E
L
CGGTHVSRTG
D
I
G
L
F
K
I
TSEGG
V
A
A
G
V
R
R
I
E
A
VTG
A
A
A
L
A
Y
LN
G
A
E
E
Q
L
K
E
A
A
S
L
VKGS
R
D
N
L
L
D
K
L
G
A
L
L
E
RN
R
S
L
E
K
E
L
E
Q
L
K
A
K
AASAAGDDL
S
A
A
A
V
E
IKG
A
K
V
L
A
A
R
LDGLD
G
K
A
L
L
A
L
V
D
Q
L
K
N
KLG
R
A
V
I
L
LGGELDG
K
V
V
L
V
AGVT
Q
D
LTGQ-
L
K
A
G
E
L
M
K
Q
A
A
A
AVGGKGGGRPDMAQGGGT
D
A
A
K
L
D
E
A
L
A
L
A
Q
R
F
V
EQGL
22
PsiBlast_CBE
88.70
73%
-85
- C1 -
3HY0
4
SYA_ECOLI
B:
[4-441]
--
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
-
G
-
L
D
K
R
N
Y
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
--------
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
---------
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
---------
E
R
I
------
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
----
A
V
A
K
V
T
G
A
T
----
D
---------------------------------------------------
L
S
-----
N
K
S
L
R
V
--
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
---
E
E
L
A
K
L
---
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
88.69
73%
-86
- C1 -
3HXV
6
SYA_ECOLI
A:
[4-441]
--
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
-
G
-
L
D
K
R
N
Y
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
--------
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
---------
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
G
M
G
L
---------
E
R
I
------
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
----
A
V
A
K
V
T
G
A
T
----
D
---------------------------------------------------
L
S
-----
N
K
S
L
R
V
--
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
---
E
E
L
A
K
L
---
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
88.64
73%
-86
- C1 -
3HXU
5
SYA_ECOLI
A:
[4-441]
--
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
-
G
-
L
D
K
R
N
Y
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
--------
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
---------
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
G
M
G
L
---------
E
R
I
------
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
----
A
V
A
K
V
T
G
A
T
----
D
---------------------------------------------------
L
S
-----
N
K
S
L
R
V
--
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
---
E
E
L
A
K
L
---
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
88.54
73%
-84
- C1 -
3HXZ
6
SYA_ECOLI
B:
[4-441]
--
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
-
G
-
L
D
K
R
N
Y
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
--------
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
---------
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
---------
E
R
I
------
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
----
A
V
A
K
V
T
G
A
T
----
D
---------------------------------------------------
L
S
-----
N
K
S
L
R
V
--
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
---
E
E
L
A
K
L
---
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
88.51
73%
-87
- C1 -
3HXY
5
SYA_ECOLI
A:
[4-441]
--
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
-
G
-
L
D
K
R
N
Y
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
--------
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
---------
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
G
M
G
L
---------
E
R
I
------
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
----
A
V
A
K
V
T
G
A
T
----
D
---------------------------------------------------
L
S
-----
N
K
S
L
R
V
--
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
---
E
E
L
A
K
L
---
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
88.47
73%
-85
- C1 -
3HY0
4
SYA_ECOLI
A:
[2-439]
K
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
-
G
-
L
D
K
R
N
Y
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
--------
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
---------
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
---------
E
R
I
------
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
----
A
V
A
K
V
T
G
A
T
----
D
---------------------------------------------------
L
S
-----
N
K
S
L
R
V
--
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
---
E
E
L
A
K
L
---
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
88.47
73%
-85
- C1 -
3HXZ
6
SYA_ECOLI
A:
[4-441]
--
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
-
G
-
L
D
K
R
N
Y
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
--------
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
---------
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
---------
E
R
I
------
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
----
A
V
A
K
V
T
G
A
T
----
D
---------------------------------------------------
L
S
-----
N
K
S
L
R
V
--
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
---
E
E
L
A
K
L
---
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
88.41
73%
-86
- C1 -
3HY0
4
SYA_ECOLI
A:
[4-441]
--
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
-
G
-
L
D
K
R
N
Y
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
--------
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
---------
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
---------
E
R
I
------
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
----
A
V
A
K
V
T
G
A
T
----
D
---------------------------------------------------
L
S
-----
N
K
S
L
R
V
--
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
---
E
E
L
A
K
L
---
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
88.26
73%
-85
- C1 -
3HXW
5
SYA_ECOLI
A:
[4-441]
--
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
-
G
-
L
D
K
R
N
Y
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
--------
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
---------
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
G
M
G
L
---------
E
R
I
------
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
----
A
V
A
K
V
T
G
A
T
----
D
---------------------------------------------------
L
S
-----
N
K
S
L
R
V
--
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
---
E
E
L
A
K
L
---
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
88.23
73%
-85
- C1 -
3HXZ
4
SYA_ECOLI
C:
[4-441]
--
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
-
G
-
L
D
K
R
N
Y
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
--------
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
---------
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
---------
E
R
I
------
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
----
A
V
A
K
V
T
G
A
T
----
D
---------------------------------------------------
L
S
-----
N
K
S
L
R
V
--
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
---
E
E
L
A
K
L
---
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
88.13
73%
-85
- C1 -
3HXZ
4
SYA_ECOLI
D:
[4-441]
--
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
-
G
-
L
D
K
R
N
Y
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
--------
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
---------
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
---------
E
R
I
------
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
----
A
V
A
K
V
T
G
A
T
----
D
---------------------------------------------------
L
S
-----
N
K
S
L
R
V
--
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
---
E
E
L
A
K
L
---
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
88.03
73%
-86
- C1 -
3HXX
3
SYA_ECOLI
A:
[4-441]
--
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
-
G
-
L
D
K
R
N
Y
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
--------
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
---------
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
G
M
G
L
---------
E
R
I
------
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
----
A
V
A
K
V
T
G
A
T
----
D
---------------------------------------------------
L
S
-----
N
K
S
L
R
V
--
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
---
E
E
L
A
K
L
---
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
87.89
30%
-77
- C1 -
3WQY
1
SYA_ARCFU
A:
[60-903]
F
E
L
D
E
M
R
E
Y
Y
L
N
F
F
E
R
R
G
H
G
R
I
E
R
Y
P
V
V
A
R
W
R
T
D
I
Y
L
T
I
A
S
I
A
D
F
Q
P
F
V
T
-
S
G
V
A
P
P
P
A
N
P
L
T
I
S
Q
P
C
I
R
L
----
D
D
L
D
S
V
G
R
T
G
R
H
L
T
L
F
E
M
M
A
H
H
A
F
N
Y
PGKEI
Y
W
K
N
E
T
V
A
Y
C
T
E
L
L
N
E
---
L
G
V
K
K
E
D
I
--------------------------
V
Y
----------
K
E
E
P
W
A
G
G
--
G
N
A
--------
G
P
C
L
E
A
I
V
-------------------
G
G
L
E
V
A
T
L
V
---------
F
M
N
L
E
E
H
P
E
G
DIEIKG
A
R
Y
R
K
M
D
N
Y
I
V
D
T
G
Y
G
L
---------
E
R
F
------
V
W
A
S
K
G
T
P
T
V
Y
D
A
-
I
F
P
E
V
V
D
----
T
I
I
D
N
S
N
V
S
----
F
NRED
E
R
V
R
R
I
V
A
E
S
S
K
L
A
G
I
M
G
E
L
RG
E
R
L
N
Q
L
R
K
S
V
A
D
T
V
GVS
V
E
E
L
E
G
I
V
V
P
-----
L
E
K
V
Y
S
--
L
A
D
H
T
R
C
I
L
F
M
L
G
D
G
L
V
P
S
N
A
G
A
G
Y
L
A
R
L
M
I
R
R
S
L
R
L
A
E
E
L
E
L
G
L
-
D
L
Y
D
L
V
E
M
H
K
K
I
L
G
F
---
E
F
D
V
P
L
S
T
V
Q
E
I
L
E
L
E
K
E
R
Y
R
T
T
V
S
K
G
T
R
L
V
E
---
R
L
V
E
R
-----
K
K
K
L
E
K
D
D
L
I
E
L
Y
D
S
H
G
I
P
V
E
L
A
V
G
I
A
A
E
K
G
A
E
V
E
M
P
K
D
I
-
Y
A
E
L
A
K
R
H
S
K
A
E
K
V
-
Q
E
K
K
------
I
T
L
Q
N
E
Y
P
A
T
E
K
L
Y
Y
D
D
P
T
LL
E
F
E
A
E
V
I
G
---
V
E
-------------
G
D
F
----
V
I
L
N
R
S
A
F
Y
P
E
S
G
G
Q
D
N
D
V
G
Y
L
I
A
N
G
G
K
F
E
V
V
D
V
L
E
A
D
G
V
V
L
H
V
V
K
G
--
A
K
P
E
V
G
T
K
V
K
G
V
I
D
S
D
V
R
W
R
H
M
R
H
H
S
A
T
H
V
L
L
Y
S
L
Q
K
V
L
G
N
H
V
W
Q
A
G
A
R
K
E
F
S
K
A
R
L
D
V
T
H
F
R
R
P
S
E
E
E
I
K
E
I
E
M
L
A
N
R
E
I
L
A
N
K
P
I
K
W
E
W
M
D
R
I
E
A
E
R
K
F
G
F
R
L
Y
Q
--
G
G
V
P
P
G
R
K
I
R
V
V
Q
V
G
D
--
D
V
Q
A
C
G
G
T
H
C
R
S
T
G
E
I
G
M
L
K
I
L
K
V
E
S
I
Q
D
G
V
I
R
F
E
F
A
A
G
E
A
A
I
E
A
V
E
E
M
E
R
L
L
R
E
A
S
S
I
L
R
V
E
P
A
K
L
P
K
T
V
E
R
F
F
E
E
W
K
D
Q
R
K
E
I
E
R
L
K
S
V
I
A
D
L
W
A
D
I
L
M
E
R
A
E
E
F
D
S
M
K
V
V
A
E
V
V
D
-
A
D
M
Q
A
L
Q
K
L
A
E
R
L
A
E
K
G
--
A
V
G
C
L
M
A
K
G
E
G
K
V
F
V
-
V
T
F
S
G
---
Q
K
-
Y
D
A
R
E
L
L
R
E
I
G
R
V
A
K
G
S
G
G
G
R
K
D
V
A
Q
G
A
V
Q
Q
L
L
D
R
E
E
M
L
D
V
I
F
R
F
L
S
E
H
E
8
PsiBlast_PDB
87.60
73%
-82
- C1 -
3HY1
4
SYA_ECOLI
A:
[4-440]
--
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
-
G
-
L
D
K
R
N
Y
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
--------
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
---------
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
---------
E
R
I
------
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
----
A
V
A
K
V
T
G
A
T
----
D
---------------------------------------------------
L
S
-----
N
K
S
L
R
V
--
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
---
E
E
L
A
K
L
---
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
85.66
73%
-89
- C1 -
3HY1
1
SYA_ECOLI
B:
[4-437]
--
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
-
G
-
L
D
K
R
N
Y
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
--------
G
P
C
T
E
I
F
Y
D
H
-----------------
R
Y
I
E
I
W
N
I
V
---------
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
---------
E
R
I
------
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
----
A
V
A
K
V
T
G
A
T
----
D
---------------------------------------------------
L
S
-----
N
K
S
L
R
V
--
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
---
E
E
L
A
K
L
---
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
83.92
28%
-68
- C1 -
3WQY
1
SYA_ARCFU
A:
[64-903]
----
E
M
R
E
Y
Y
L
N
F
F
E
R
R
G
H
G
R
I
E
R
Y
P
V
V
A
R
W
R
T
D
I
Y
L
T
I
A
S
I
A
D
F
Q
P
F
V
T
S
G
-
V
A
P
P
P
A
N
P
L
T
I
S
Q
P
C
I
R
L
----
D
D
L
D
S
V
G
R
T
G
R
H
L
T
L
F
E
M
M
A
H
H
A
F
N
Y
PGKEI
Y
W
K
N
E
T
V
A
Y
C
T
E
L
L
N
-----------------------------
E
L
G
V
K
K
E
D
I
V
----
Y
K
E
E
P
W
A
G
G
-----
G
N
A
G
P
C
L
E
A
I
V
GGL
E
V
A
T
L
V
F
M
N
----
L
E
E
H
P
E
G
D
I
E
I
K
G
A
R
Y
R
K
M
D
N
Y
I
V
D
T
G
Y
G
L
E
R
F
V
W
A
S
K
G
T
P
T
-------
V
Y
D
A
I
F
P
E
V
V
D
T
I
I
D
N
SNVSFNRED
E
R
V
R
R
I
V
A
E
S
S
K
L
A
G
I
M
G
E
L
R
G
E
R
L
N
Q
L
R
K
----
S
V
A
D
T
V
G
V
S
----
V
---------------------------------------------------
E
E
L
E
G
I
V
V
P
L
E
K
V
Y
S
L
A
D
H
T
R
C
I
L
F
M
L
G
D
G
L
V
P
S
N
A
G
A
G
Y
L
A
R
L
M
I
R
R
S
L
R
L
A
E
E
L
E
L
-
G
L
D
L
Y
D
L
V
E
M
H
K
K
I
L
G
F
E
F
---
D
V
P
L
S
T
V
Q
E
I
L
E
L
E
K
E
R
Y
R
T
T
V
S
K
G
T
R
L
V
E
---
R
-
L
V
E
R
---
K
K
K
L
E
K
D
D
L
I
-
E
L
Y
D
S
H
G
I
P
V
E
L
A
V
G
I
A
A
E
K
---------
G
-
A
E
V
E
M
P
K
D
------------
I
Y
---
A
E
L
A
K
R
H
S
K
A
E
K
V
Q
E
K
K
I
T
---
L
Q
N
E
Y
P
A
TEK
L
Y
Y
D
D
P
T
L
L
E
F
E
A
E
V
I
G
V
EGD
F
V
I
L
N
R
S
A
F
Y
P
E
S
G
G
Q
D
N
D
V
G
Y
L
I
A
N
G
G
K
F
E
V
V
D
V
L
E
A
D
G
V
V
L
H
--
V
V
K
G
A
K
P
E
V
G
T
K
V
K
G
V
I
D
S
D
V
R
W
R
H
M
R
H
H
S
A
T
H
V
L
L
Y
S
L
Q
K
V
L
G
N
H
V
W
Q
A
G
A
R
K
E
F
S
K
A
R
L
D
V
T
H
F
R
R
P
S
E
E
E
I
K
E
I
E
M
L
A
N
R
E
I
L
A
N
K
P
I
K
W
E
W
M
D
R
I
E
A
E
R
K
F
G
F
-
R
L
Y
QG
G
V
P
-
P
G
R
K
I
R
V
V
Q
V
G
D
D
--
V
Q
A
C
G
G
T
H
C
R
S
T
G
E
I
G
M
L
K
I
L
K
V
E
S
I
Q
D
G
V
I
R
F
E
F
A
A
G
E
A
A
I
E
A
V
E
E
M
E
R
L
L
R
E
A
S
S
I
L
R
V
E
P
A
K
L
P
K
T
V
E
R
F
F
E
E
W
K
D
Q
R
K
E
I
E
R
L
K
S
V
I
A
D
L
W
A
D
I
L
M
E
R
A
E
E
F
D
S
M
K
V
V
A
E
V
V
D
A
-
D
M
Q
A
L
Q
K
L
A
E
R
L
A
E
K
G
A
V
G
C
L
M
A
K
G
E
--
G
K
V
F
V
V
T
-----
F
S
G
Q
K
Y
D
A
R
E
L
L
R
E
I
G
R
V
A
K
G
S
G
G
G
R
K
D
V
A
Q
G
A
V
Q
Q
L
L
D
R
E
E
M
L
D
V
I
F
R
F
L
S
E
H
E
16
PsiBlast_PDB
82.96
28%
-71
- C1 -
3WQZ
2
SYA_ARCFU
A:
[64-903]
----
E
M
R
E
Y
Y
L
N
F
F
E
R
R
G
H
G
R
I
E
R
Y
P
V
V
A
R
W
R
T
D
I
Y
L
T
I
A
S
I
A
D
F
Q
P
F
V
T
S
G
-
V
A
P
P
P
A
N
P
L
T
I
S
Q
P
C
I
R
L
----
D
D
L
D
S
V
G
R
T
G
R
H
L
T
L
F
E
M
M
A
H
H
A
F
N
Y
PGKEI
Y
W
K
N
E
T
V
A
Y
C
T
E
L
L
N
-----------------------------
E
L
G
V
K
K
E
D
I
V
----
Y
K
E
E
P
W
A
G
G
-----
G
N
A
G
P
C
L
E
A
I
V
GGL
E
V
A
T
L
V
F
M
N
----
L
E
E
H
P
E
G
D
I
E
I
K
G
A
R
Y
R
K
M
D
N
Y
I
V
D
T
G
Y
G
L
E
R
F
V
W
A
S
K
G
T
P
T
-------
V
Y
D
A
I
F
P
E
V
V
D
T
I
I
D
N
SNVSFNRED
E
R
V
R
R
I
V
A
E
S
S
K
L
A
G
I
M
G
E
L
R
G
E
R
L
N
Q
L
R
K
----
S
V
A
D
T
V
G
V
S
----
V
---------------------------------------------------
E
E
L
E
G
I
V
V
P
L
E
K
V
Y
S
L
A
D
H
T
R
C
I
L
F
M
L
G
D
G
L
V
P
S
N
A
G
A
G
Y
L
A
R
L
M
I
R
R
S
L
R
L
A
E
E
L
E
L
-
G
L
D
L
Y
D
L
V
E
M
H
K
K
I
L
G
F
E
F
---
D
V
P
L
S
T
V
Q
E
I
L
E
L
E
K
E
R
Y
R
T
T
V
S
K
G
T
R
L
V
E
---
R
-
L
V
E
R
---
K
K
K
L
E
K
D
D
L
I
-
E
L
Y
D
S
H
G
I
P
V
E
L
A
V
G
I
A
A
E
K
---------
G
-
A
E
V
E
M
P
K
D
------------
I
Y
---
A
E
L
A
K
R
H
S
K
A
E
K
V
Q
E
K
K
I
T
---
L
Q
N
E
Y
P
A
TEK
L
Y
Y
D
D
P
T
L
L
E
F
E
A
E
V
I
G
V
EGD
F
V
I
L
N
R
S
A
F
Y
P
E
S
G
G
Q
D
N
D
V
G
Y
L
I
A
N
G
G
K
F
E
V
V
D
V
L
E
A
D
G
V
V
L
H
--
V
V
K
G
A
K
P
E
V
G
T
K
V
K
G
V
I
D
S
D
V
R
W
R
H
M
R
H
H
S
A
T
H
V
L
L
Y
S
L
Q
K
V
L
G
N
H
V
W
Q
A
G
A
R
K
E
F
S
K
A
R
L
D
V
T
H
F
R
R
P
S
E
E
E
I
K
E
I
E
M
L
A
N
R
E
I
L
A
N
K
P
I
K
W
E
W
M
D
R
I
E
A
E
R
K
F
G
F
-
R
L
Y
QG
G
V
P
-
P
G
R
K
I
R
V
V
Q
V
G
D
D
--
V
Q
A
C
G
G
T
H
C
R
S
T
G
E
I
G
M
L
K
I
L
K
V
E
S
I
Q
D
G
V
I
R
F
E
F
A
A
G
E
A
A
I
E
A
V
E
E
M
E
R
L
L
R
E
A
S
S
I
L
R
V
E
P
A
K
L
P
K
T
V
E
R
F
F
E
E
W
K
D
Q
R
K
E
I
E
R
L
K
S
V
I
A
D
L
W
A
D
I
L
M
E
R
A
E
E
F
D
S
M
K
V
V
A
E
V
V
D
A
-
D
M
Q
A
L
Q
K
L
A
E
R
L
A
E
K
G
A
V
G
C
L
M
A
K
G
E
--
G
K
V
F
V
V
T
-----
F
S
G
Q
K
Y
D
A
R
E
L
L
R
E
I
G
R
V
A
K
G
S
G
G
G
R
K
D
V
A
Q
G
A
V
Q
Q
L
L
D
R
E
E
M
L
D
V
I
F
R
F
L
S
E
H
E
32
HHSearch
80.16
54%
-84
- C1 -
1YFS
1
SYA_AQUAE
A:
[3-458]
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
-
G
-
L
E
K
R
P
Y
K
R
A
T
S
C
Q
K
C
L
R
V
S
G
K
H
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
E
--
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
G
E
-------
E
D
N
F
W
Q
M
G
D
V
G
P
C
--------
G
P
S
S
E
I
Y
V
D
R
G
E
E
Y
---------
E
G
D
E
R
Y
L
E
I
W
N
L
V
---------
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
---------
E
R
I
------
A
S
V
L
Q
G
K
N
S
N
F
E
I
D
I
I
F
P
L
I
Q
----
F
G
E
E
V
S
G
K
K
YGEK
F
---------------------------------------------------
E
T
-----
D
V
A
L
R
V
--
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
---
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
--
G
-
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
-------P
V
Y
S
H
L
K
E
L
G
K
T
S
A
F
V
G
A
A
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
77.79
54%
-88
- C1 -
3HTZ
-
SYA_AQUAE
A:
[2-425]
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
-
G
-
L
E
K
R
P
Y
K
R
A
T
S
C
Q
K
C
L
R
V
S
G
K
H
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
G
E
-------
E
D
N
F
W
Q
M
G
D
V
G
P
C
--------
G
P
S
S
E
I
Y
V
D
R
G
E
E
Y
---------
E
G
D
E
R
Y
L
E
I
W
N
L
V
---------
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
---------
E
R
I
------
A
S
V
L
Q
G
K
N
S
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
V
S
G
K
K
Y
G
E
K
----
F
---------------------------------------------------
E
T
-----
D
V
A
L
R
V
--
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
---
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
--
G
-
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
P
V
Y
S
H
L
K
E
---
L
G
K
T
S
A
F
V
G
A
A
A
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
77.68
54%
-86
- C1 -
1YFT
1
SYA_AQUAE
A:
[3-426]
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
-
G
-
L
E
K
R
P
Y
K
R
A
T
S
C
Q
K
C
L
R
V
S
G
K
H
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
G
E
-------
E
D
N
F
W
Q
M
G
D
V
G
P
C
--------
G
P
S
S
E
I
Y
V
D
R
G
E
E
Y
---------
E
G
D
E
R
Y
L
E
I
W
N
L
V
---------
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
---------
E
R
I
------
A
S
V
L
Q
G
K
N
S
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
V
S
G
K
K
Y
G
E
K
----
F
---------------------------------------------------
E
T
-----
D
V
A
L
R
V
--
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
---
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
--
G
-
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
P
V
Y
S
H
L
K
---
E
L
G
K
T
S
A
F
V
G
A
A
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
77.67
54%
-85
- C1 -
1YFR
3
SYA_AQUAE
A:
[3-426]
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
-
G
-
L
E
K
R
P
Y
K
R
A
T
S
C
Q
K
C
L
R
V
S
G
K
H
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
G
E
-------
E
D
N
F
W
Q
M
G
D
V
G
P
C
--------
G
P
S
S
E
I
Y
V
D
R
G
E
E
Y
---------
E
G
D
E
R
Y
L
E
I
W
N
L
V
---------
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
---------
E
R
I
------
A
S
V
L
Q
G
K
N
S
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
V
S
G
K
K
Y
G
E
K
----
F
---------------------------------------------------
E
T
-----
D
V
A
L
R
V
--
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
---
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
--
G
-
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
P
V
Y
S
H
L
K
---
E
L
G
K
T
S
A
F
V
G
A
A
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
76.88
31%
-68
* C1 *
2ZTG
3
SYA_ARCFU
A:
[60-739]
F
E
L
D
E
M
R
E
Y
Y
L
N
F
F
E
R
R
G
H
G
R
I
E
R
Y
P
V
V
A
R
W
R
T
D
I
Y
L
T
I
A
S
I
A
D
F
Q
P
F
V
T
-
S
G
V
A
P
P
P
A
N
P
L
T
I
S
Q
P
C
I
R
L
----
D
D
L
D
S
V
G
R
T
G
R
H
L
T
L
F
E
M
M
A
H
H
A
F
N
Y
PGKEI
Y
W
K
N
E
T
V
A
Y
C
T
E
L
L
N
E
---
L
G
V
K
K
E
D
I
--------------------------
V
Y
----------
K
E
E
P
W
A
G
G
--
G
N
A
--------
G
P
C
L
E
A
I
V
-------------------
G
G
L
E
V
A
T
L
V
---------
F
M
N
L
E
E
H
P
E
G
DIEIKG
A
R
Y
R
K
M
D
N
Y
I
V
D
T
G
Y
G
L
---------
E
R
F
------
V
W
A
S
K
G
T
P
T
V
Y
D
A
-
I
F
P
E
V
V
D
----
T
I
I
D
N
S
N
V
S
----
F
NRED
E
R
V
R
R
I
V
A
E
S
S
K
L
A
GIMGELRGERL
N
Q
L
R
K
S
V
A
D
T
V
GVS
V
E
E
L
E
G
I
V
V
P
-----
L
E
K
V
Y
S
--
L
A
D
H
T
R
C
I
L
F
M
L
G
D
G
L
V
P
S
N
A
G
A
G
Y
L
A
R
L
M
I
R
R
S
L
R
L
A
E
E
L
E
L
G
L
-
D
L
Y
D
L
V
E
M
H
K
K
I
L
G
F
E
F
D
V
---
P
L
S
T
V
Q
E
I
L
E
L
E
K
E
R
Y
R
T
T
V
S
K
G
T
R
L
V
E
---
R
L
V
E
R
-----
K
K
K
L
E
K
D
D
L
I
E
L
Y
D
S
H
G
I
P
V
E
L
A
V
G
I
A
A
E
K
G
A
E
V
E
M
P
--
K
D
I
Y
A
E
L
A
K
R
H
S
K
A
E
K
V
Q
E
K
K
------
I
T
L
Q
N
E
Y
P
A
T
E
K
L
Y
Y
D
D
P
T
LL
E
F
E
A
E
V
I
G
---
V
E
-------------
G
D
F
----
V
I
L
N
R
S
A
F
Y
P
E
S
G
G
Q
D
N
D
V
G
Y
L
I
A
N
G
G
K
F
E
V
V
D
V
L
E
A
D
G
V
V
L
H
V
V
K
G
--
A
K
P
E
V
G
T
K
V
K
G
V
I
D
S
D
V
R
W
R
H
M
R
H
H
S
A
T
H
V
L
L
Y
S
L
Q
K
V
L
G
N
H
V
W
Q
A
G
A
R
K
E
F
S
K
A
R
L
D
V
T
H
F
R
R
P
S
E
E
E
I
K
E
I
E
M
L
A
N
R
E
I
L
A
N
K
P
I
K
W
E
W
M
D
R
I
E
A
E
R
K
F
G
F
R
L
Y
Q
--
G
G
V
P
P
G
R
K
I
R
V
V
Q
V
G
D
--
D
V
Q
A
C
G
G
T
H
C
R
S
T
G
E
I
G
M
L
K
I
L
K
V
E
S
I
Q
D
G
V
I
R
F
E
F
A
A
G
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
76.54
54%
-83
- C1 -
1YFR
4
SYA_AQUAE
B:
[3-426]
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
-
G
-
L
E
K
R
P
Y
K
R
A
T
S
C
Q
K
C
L
R
V
S
G
K
H
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
G
E
-------
E
D
N
F
W
Q
M
G
D
V
G
P
C
--------
G
P
S
S
E
I
Y
V
D
R
G
E
E
Y
---------
E
G
D
E
R
Y
L
E
I
W
N
L
V
---------
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
---------
E
R
I
------
A
S
V
L
Q
G
K
N
S
N
F
E
I
D
I
I
F
P
L
I
Q
FGEE
V
S
G
K
K
Y
G
E
K
----
F
---------------------------------------------------
E
T
-----
D
V
A
L
R
V
--
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
EVI
Q
K
A
L
E
E
---
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
--
G
-
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
P
V
Y
S
H
L
K
---
E
L
G
K
T
S
A
F
V
G
A
A
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------