@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0923: (2016-01-25 )
MRKIIHIDCDCFYAALEMRDDPSLRGKALAVGGSPDKRGVVATCSYEARAYGVRSAMAMRTALKLCPDLLVVRPRFDVYRAVSKQIHAIFRDYTDLIEPLSLDEAYLDVSASPHFAGSATRIAQDIRRRVAEELHITVSAGVAPNKFLAKIASDWRKPDGLFVITPEQVDGFVAELPVAKLHGVGKVTAERLARMGIRTCADLRQGSKLSLVREFGSFGERLWGLAHGIDERPVEVDSRRQSVSVECTFDRDLPDLAACLEELPTLLEELDGRLQRLDGSYRPDKPFVKLKFHDFTQTTVEQSGAGRDLESYRQLLGQAFARGNRPVRLIGVGVRLLDLQGAHEQLRLF
Atome Classification :
(22 SA)
-------------------------------------------------------------------.........10........20........30.....-------------------------------...40........50........60........70...-.....80........90........100.......110-------------------....-------------------..---------------..120.......130.......140.......150.......160....--...170....-...180.......190.......200.......210......-.220.......230.......240.......250.......260.......270.......280.......290..---------.------....300....---------..----.310.......320.-...-------....330...-....340.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------------M
R
K
I
I
H
ID
C
D
C
F
Y
A
A
L
EMRDDPSLRG
K
A
L
AVGGSPD-------------------------------KR
G
V
V
A
T
CSY
E
A
R
A
Y
G
V
R
S
A
M
A
M
R
T
A
L
K
LCPD
L
L
V
VRP-
R
F
D
V
Y
R
A
V
S
K
Q
I
H
A
I
F
R
D
Y
T
D
L
IEPLSL
D
E
A
YLDVSA--------------------SPHF-------------------AG---------------
S
A
T
R
I
A
Q
D
I
R
R
R
V
A
EE
L
H
I
T
V
SAGVA
P
N
K
F
L
A
K
I
A
S
D
WRKPD
G
L
F
V
I
T
P
--
E
Q
VD
G
F
V
A
EL-
P
V
A
K
LHG
V
G
K
V
T
A
E
R
L
A
R
M
G
I
R
T
C
A
D
L
RQG
S
K
L
S
L
V
R
E
F
G
S
F
-
G
E
R
L
W
G
L
AHGIDERPVEVDSRR
Q
S
V
S
V
E
C
T
FDRD
L
P
D
L
A
A
C
L
E
E
L
P
T
L
L
E
E
L
D
G
R
L
Q
RLDGSYRPDK
P
F
V
K
L
K
FHD---------F------
T
Q
T
T
V
EQSGAG---------R
D
----
L
E
S
Y
R
Q
L
L
G
Q
A
F
-AR-GNR-------
P
V
R
L
I
G
V
G
V
R
-
L
L
DLQG
A
H
E
Q
LRLF
26
PsiBlast_CBE
95.54
49%
-123
- C3 -
4IRK
4
DPO4_ECOLI
A:
[3-341]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
-------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
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L
A
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C
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L
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L
L
P
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-
R
F
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D
--------------------
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C
-------------------
H
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---------------
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A
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L
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N
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P
N
G
Q
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V
I
T
P
--
A
E
V
P
A
F
L
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T
L
-
P
L
A
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I
P
G
V
G
K
V
S
A
A
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A
M
G
L
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G
D
V
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L
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L
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R
F
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R
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L
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F
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D
---------
F
------
Q
Q
T
T
Q
E
H
V
W
P
R
---------
L
N
K
A
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L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
-------
G
V
R
L
V
G
L
H
V
T
-
L
L
D
P
----------
29
PsiBlast_CBE
95.17
49%
-127
- C3 -
4R8U
4
?
B:
[1-337]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
-------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
-
R
F
D
A
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N
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S
R
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L
D
V
T
D
--------------------
S
V
H
C
-------------------
H
G
---------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
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Q
L
T
A
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A
P
V
K
F
L
A
K
I
A
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D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
---------
F
------
Q
Q
T
T
Q
E
H
V
W
P
R
---------
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
-------
G
V
R
L
V
G
L
H
V
T
-
L
D
------------
21
PsiBlast_CBE
94.87
49%
-119
- C3 -
4Q43
5
DPO4_ECOLI
F:
[3-342]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
-------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
-
R
F
D
A
Y
K
E
A
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N
H
I
R
E
I
F
S
R
Y
T
S
R
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P
L
S
L
D
E
A
Y
L
D
V
T
D
--------------------
S
V
H
C
-------------------
H
G
---------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
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R
L
A
K
V
K
P
D
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
---------
F
------
Q
Q
T
T
Q
E
H
V
W
P
R
---------
L
N
KADL
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
-------
G
V
R
L
V
G
L
H
V
T
-
L
L
D
P
----------
9
PsiBlast_PDB
94.77
49%
-120
- C3 -
4Q45
5
DPO4_ECOLI
F:
[3-341]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
-------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
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P
L
S
L
D
E
A
Y
L
D
V
T
D
--------------------
S
V
H
C
-------------------
H
G
---------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
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D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
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S
E
R
L
R
K
S
V
G
V
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M
A
E
D
I
H
H
W
S
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C
E
A
I
I
E
R
L
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P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
---------
F
------
Q
Q
T
T
Q
E
H
V
W
P
R
---------
L
N
KADL
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
-------
G
V
R
L
V
G
L
H
V
T
-
L
L
D
P
----------
4
PsiBlast_PDB
94.77
49%
-124
- C3 -
4R8U
4
DPO4_ECOLI
A:
[2-340]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
-------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
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L
T
L
L
P
G
-
R
F
D
A
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S
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T
S
R
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L
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L
D
E
A
Y
L
D
V
T
D
--------------------
S
V
H
C
-------------------
H
G
---------------
S
A
T
L
I
A
Q
E
I
R
Q
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I
F
N
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A
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A
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V
P
A
F
L
Q
T
L
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L
A
K
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P
G
V
G
K
V
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A
A
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L
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A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
F
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G
R
I
L
W
E
R
S
Q
G
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R
L
R
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G
V
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E
D
I
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H
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S
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C
E
A
I
I
E
R
L
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L
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R
L
A
K
V
K
P
D
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
---------
F
------
Q
Q
T
T
Q
E
H
V
W
P
R
---------
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
-------
G
V
R
L
V
G
L
H
V
T
-
L
L
D
-----------
1
PsiBlast_PDB
94.72
49%
-121
- C3 -
4IR1
5
DPO4_ECOLI
F:
[3-342]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
-------------------------------
R
R
G
V
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S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
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M
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L
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L
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L
T
L
L
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-
R
F
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R
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R
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T
S
R
I
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P
L
S
L
D
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A
Y
L
D
V
T
D
--------------------
S
V
H
C
-------------------
H
G
---------------
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A
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L
I
A
Q
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L
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C
D
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A
R
Q
G
V
K
L
K
F
D
D
---------
F
------
Q
Q
T
T
Q
E
H
V
W
P
R
---------
L
N
KADL
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
-------
G
V
R
L
V
G
L
H
V
T
-
L
L
D
P
----------
5
PsiBlast_PDB
94.67
49%
-120
- C3 -
4IRC
5
DPO4_ECOLI
F:
[3-341]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
-------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
--------------------
S
V
H
C
-------------------
H
G
---------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
---------
F
------
Q
Q
T
T
Q
E
H
V
W
P
R
---------
L
N
KADL
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
-------
G
V
R
L
V
G
L
H
V
T
-
L
L
D
P
----------
2
PsiBlast_PDB
94.65
49%
-121
- C3 -
4IR9
5
DPO4_ECOLI
F:
[3-342]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
-------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
--------------------
S
V
H
C
-------------------
H
G
---------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
---------
F
------
Q
Q
T
T
Q
E
H
V
W
P
R
---------
L
N
KADL
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
-------
G
V
R
L
V
G
L
H
V
T
-
L
L
D
P
----------
8
PsiBlast_PDB
94.57
49%
-121
- C3 -
4Q44
7
DPO4_ECOLI
A:
[3-341]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
-------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
--------------------
S
V
H
C
-------------------
H
G
---------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
---------
F
------
Q
Q
T
T
Q
E
H
V
W
P
R
---------
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
-------
G
V
R
L
V
G
L
H
V
T
-
L
L
D
P
----------
3
PsiBlast_PDB
94.16
49%
-123
- C3 -
4Q43
7
DPO4_ECOLI
A:
[3-342]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
-------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
--------------------
S
V
H
C
-------------------
H
G
---------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
---------
F
------
Q
Q
T
T
Q
E
H
V
W
P
R
---------
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
-------
G
V
R
L
V
G
L
H
V
T
-
L
L
D
P
----------
6
PsiBlast_PDB
94.10
49%
-116
- C3 -
4IRD
5
DPO4_ECOLI
F:
[3-341]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
-------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
--------------------
S
V
H
C
-------------------
H
G
---------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
---------
F
------
Q
Q
T
T
Q
E
H
V
W
P
R
---------
L
N
KADL
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
-------
G
V
R
L
V
G
L
H
V
T
-
L
L
D
P
----------
24
PsiBlast_CBE
93.94
49%
-121
- C3 -
4Q45
7
DPO4_ECOLI
A:
[3-341]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
-------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
--------------------
S
V
H
C
-------------------
H
G
---------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
---------
F
------
Q
Q
T
T
Q
E
H
V
W
P
R
---------
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
-------
G
V
R
L
V
G
L
H
V
T
-
L
L
D
P
----------
7
PsiBlast_PDB
93.91
49%
-122
- C3 -
4IRK
6
DPO4_ECOLI
B:
[3-341]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
-------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
--------------------
S
V
H
C
-------------------
H
G
---------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
---------
F
------
Q
Q
T
T
Q
E
H
V
W
P
R
---------
L
N
KADL
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
-------
G
V
R
L
V
G
L
H
V
T
-
L
L
D
P
----------
27
PsiBlast_CBE
93.49
49%
-122
- C3 -
4IRD
7
DPO4_ECOLI
A:
[3-341]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
-------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
--------------------
S
V
H
C
-------------------
H
G
---------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
---------
F
------
Q
Q
T
T
Q
E
H
V
W
P
R
---------
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
-------
G
V
R
L
V
G
L
H
V
T
-
L
L
D
P
----------
22
PsiBlast_CBE
93.36
49%
-120
- C3 -
4IR9
7
DPO4_ECOLI
A:
[3-342]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
-------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
--------------------
S
V
H
C
-------------------
H
G
---------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
---------
F
------
Q
Q
T
T
Q
E
H
V
W
P
R
---------
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
-------
G
V
R
L
V
G
L
H
V
T
-
L
L
D
P
----------
23
PsiBlast_CBE
93.28
49%
-120
- C3 -
4IR1
7
DPO4_ECOLI
A:
[3-342]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
-------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
--------------------
S
V
H
C
-------------------
H
G
---------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
---------
F
------
Q
Q
T
T
Q
E
H
V
W
P
R
---------
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
-------
G
V
R
L
V
G
L
H
V
T
-
L
L
D
P
----------
25
PsiBlast_CBE
93.10
49%
-119
- C3 -
4Q44
5
DPO4_ECOLI
F:
[3-341]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
-------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
--------------------
S
V
H
C
-------------------
H
G
---------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
---------
F
------
Q
Q
T
T
Q
E
H
V
W
P
R
---------
L
N
KADL
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
-------
G
V
R
L
V
G
L
H
V
T
-
L
L
D
P
----------
28
PsiBlast_CBE
92.98
49%
-118
- C3 -
4IRC
7
DPO4_ECOLI
A:
[3-341]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
-------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
--------------------
S
V
H
C
-------------------
H
G
---------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
---------
F
------
Q
Q
T
T
Q
E
H
V
W
P
R
---------
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
-------
G
V
R
L
V
G
L
H
V
T
-
L
L
D
P
----------
111
HHSearch
79.01
29%
-105
- C3 -
3GQC
-
REV1_HUMAN
A:
[416-828]
-------------------------------------------------------------------
Q
S
C
I
M
H
V
D
M
D
C
F
F
V
S
V
G
I
R
N
R
P
D
L
K
G
K
P
V
A
V
T
S
N
R
G
TGRAPLRPGAN
P
Q
L
E
W
Q
Y
Y
Q
N
KILKGIDSVL
S
R
A
E
I
A
S
C
S
Y
E
A
R
Q
L
G
I
K
N
G
M
F
F
G
H
A
K
Q
L
C
P
N
L
Q
A
V
P
Y
-
D
F
H
A
Y
K
E
V
A
Q
T
L
Y
E
T
L
A
S
Y
T
H
N
I
E
A
V
S
C
D
E
A
L
V
D
I
T
E
--------------------
I
L
A
E
-------------------
T
K
L--------------
T
P
D
E
F
A
N
A
V
R
M
E
I
K
D
Q
T
K
C
A
A
S
V
G
I
G
S
N
I
L
L
A
R
M
A
T
R
K
A
K
P
D
G
Q
Y
H
L
K
P
--
E
E
V
D
D
F
I
R
G
Q
-
L
V
T
N
L
P
G
V
G
H
S
M
E
S
K
L
A
S
L
G
I
K
T
C
G
D
L
Q
Y
M
T
M
A
K
L
Q
K
E
F
G
P
K
T
G
Q
M
L
Y
R
F
C
R
G
L
D
D
R
P
V
R
T
E
K
E
R
K
S
V
S
A
E
I
N
Y
G
I
R
F
T
Q
P
K
E
A
E
A
F
L
L
S
L
S
E
E
I
Q
R
R
L
E
A
T
G
M
K
--
G
K
R
L
T
L
K
I
M
V
R
K
PGAPVETAK
F
GGH
G
I
C
D
N
I
A
R
T
V
T
L
D
Q
ATDN
A
----
K
I
----
I
G
K
A
M
L
N
M
F
H
T
M
-
K
L
-
N
I
S
-------
D
M
R
G
V
G
I
H
V
N
Q
L
V
P
T
N
---------
115
HHSearch
78.90
29%
-114
- C3 -
3OSN
6
POLI_HUMAN
A:
[27-414]
-------------------------------------------------------------------
S
R
V
I
V
H
V
D
L
D
C
F
Y
A
Q
V
E
M
I
S
N
P
E
L
K
D
K
P
L
G
V
Q
Q
-----------------------------------
K
Y
L
V
V
T
C
N
Y
E
A
R
K
L
G
V
K
K
L
M
N
V
R
D
A
K
E
K
C
P
Q
L
V
L
V
N
G
E
D
L
T
R
Y
R
E
M
S
Y
K
V
T
E
L
L
E
E
F
S
P
V
V
E
R
L
G
F
D
E
N
F
V
D
L
T
E
--------------------
M
V
E
K
R
L
Q
Q
LQSDELSA
V
T
V
S
G
HV
Y
N
N
Q
S
I
N
LLD
V
L
H
I
R
L
L
V
G
S
Q
I
A
A
E
M
R
E
A
M
Y
N
Q
L
G
L
T
G
C
A
G
V
A
S
N
K
L
L
A
K
L
V
S
G
V
F
K
P
N
Q
Q
T
V
L
L
P
--
E
S
C
Q
H
L
I
H
S
L
N
H
I
K
E
I
P
G
I
G
Y
K
T
A
K
C
L
E
A
L
G
I
N
S
V
R
D
L
Q
T
F
S
P
K
I
L
E
K
E
L
G
I
S
V
A
Q
R
I
Q
K
L
S
F
G
E
D
N
S
P
V
I
L
S
G
P
P
Q
S
F
S
E
E
D
S
F
K
K
-
C
S
S
E
V
E
A
K
N
K
I
E
E
L
L
A
S
L
L
N
R
V
C
Q
D
G
R
K
--
P
H
T
V
R
L
I
I
R
R
Y
S
---------
S
E
K
H
Y
--
G
R
E
S
R
Q
C
P
I
P
S
HVIQKYD
V
M
T
P
----
M
V
D
I
L
M
K
L
F
R
N
M
V
N
V
K
M
P
F
-------
H
L
T
L
L
S
V
C
F
C
N
L
K
------------
104
Fugue
78.77
34%
-111
- C3 -
2W7O
5
POLK_HUMAN
A:
[15-501]
KEK
I
N
K
I
I
M
E
A
T
KGS
R
F
Y
G
N
E
L
K
K
E
K
Q
V
N
Q
R
I
E
N
M
M
Q
Q
K
A
Q
IT
S
Q
Q
L
R
K
A
Q
L
Q
V
D
R
F
A
M
E
L
E
Q
S
RNL
S
N
T
I
V
H
I
D
M
D
A
F
Y
A
A
V
E
M
R
D
N
P
E
L
K
D
K
P
I
A
V
G
S
-----------------------------------
M
S
M
L
S
T
S
N
Y
H
A
R
R
F
G
V
R
A
A
M
P
G
F
I
A
K
R
L
C
P
Q
L
I
I
V
P
P
-
N
F
D
K
Y
R
A
V
S
K
E
V
K
E
I
L
A
D
Y
D
P
N
F
M
A
M
S
L
D
E
A
Y
L
N
I
T
K
H
L
E
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R
Q
NWPEDKRRYFIKQN
S
V
V
F
-------------------
G
T
---------------
S
A
Q
E
V
V
K
E
I
R
F
R
I
E
Q
K
T
T
L
T
A
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A
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I
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N
T
M
L
A
K
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C
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D
K
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K
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N
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Q
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R
Q
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M
D
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D
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-
P
I
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G
I
G
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V
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K
M
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K
A
L
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C
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Y
Q
Q
R
A
L
L
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L
L
F
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S
-
W
H
Y
F
L
H
I
S
L
G
L
G
S
T
H
L
T
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E
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M
S
V
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R
T
F
-
S
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L
C
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L
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A
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L
Q
K
E
R
L
K
G
R
T
V
T
I
K
L
K
N
V
N
F
E
---------
V
------
K
T
R
A
S
T
V
S
S
V
V
---------
S
T
----
A
E
E
I
F
A
I
A
K
E
L
L
-
K
T
-
E
I
D
ADFPHPL
R
L
R
L
M
G
V
R
I
S
-
S
F
P
N
E
E
--------
101
Fugue
76.09
34%
-103
- C3 -
2OH2
4
POLK_HUMAN
A:
[15-499]
KE
K
I
N
K
I
I
M
E
A
T
KGS
R
F
Y
G
N
E
L
K
K
E
K
Q
V
N
Q
R
I
E
N
M
M
Q
Q
K
A
Q
IT
S
Q
Q
L
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K
A
Q
L
Q
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D
R
F
A
M
E
L
E
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S
RNL
S
N
T
I
V
H
I
D
M
D
A
F
Y
A
A
V
E
M
R
D
N
P
E
L
K
D
K
P
I
A
V
G
S
-----------------------------------
M
S
M
L
S
T
S
N
Y
H
A
R
R
F
G
V
R
A
A
M
P
G
F
I
A
K
R
L
C
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Q
L
I
I
V
P
P
-
N
F
D
K
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R
A
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K
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V
K
E
I
L
A
D
Y
D
P
N
F
M
A
M
S
L
D
E
A
Y
L
N
I
T
K
--------------------
H
L
E
E
R
Q
N
WPEDKR
R
Y
F
I
KN
S
V
V
F
G
T
---------------
S
A
Q
E
V
V
K
E
I
R
F
R
I
E
Q
K
T
T
L
T
A
S
A
G
I
A
P
N
T
M
L
A
K
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C
S
D
K
N
K
P
N
G
Q
Y
Q
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D
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I
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D
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M
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K
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L
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C
T
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Y
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A
L
L
S
L
L
F
S
E
T
S
-
W
H
Y
F
L
H
I
S
L
G
L
G
S
T
H
L
T
R
D
G
E
R
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M
S
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E
R
T
F
S
E
I
-
N
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A
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C
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E
L
C
S
E
L
A
Q
D
L
Q
K
E
R
L
K
G
R
--
T
V
T
I
K
L
K
N
V
N
---------
F
------
E
V
K
T
R
A
S
T
V
S
S
VV-------
S
T
----
A
E
E
I
F
A
I
A
K
E
L
L
-
K
T
-
E
I
D
-------
A
D
F
P
H
P
L
R
L
R
-
L
M
G
V
R
I
S
S
F
P
----