@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0944: (2016-01-25 )
MPKLCNVVVLISGSGSNLQALIDSLRDGATPARIRAVISNRADAYGLERARQAGIQTEVLDHKAYADRESFDEALAQRIDAHEPHLVILAGFMRILSADFVRHYQGRLLNIHPSLLPRHKGLHTHQRALEAGDREHGCSVHFVTEELDGGPLVVQAVIPVESQDTPERLARRVHEEEHRIYPLAMRWFAEGRLRLGEQGALLDGQALPATGHQIRTKEIRNA
Atome Classification :
(39 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.....-..210.......220
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPKL
C
N
V
V
V
L
I
SGSG
S
N
L
Q
A
L
I
D
S
L
RDGA
T
P
A
R
I
R
A
V
I
SNRADAY
G
L
E
R
A
R
QAGIQTEVLDHKAYA
D
R
E
S
F
D
E
A
L
A
Q
RIDAHEPH
L
V
I
L
A
G
F
M
R
I
L
S
A
D
F
V
R
H
YQG
R
L
L
NI
H
P
S
L
L
P
RHKG
L
H
T
H
Q
R
A
L
EAGDREHG
C
S
V
H
F
V
T
EELDGG
P
L
V
V
Q
A
V
IPVESQD
T
P
E
R
L
A
R
R
V
H
E
E
EHR
I
Y
P
L
A
M
R
W
F
AEG
R
L
RLGEQGALLDGQAL-PATG
H
Q
I
R
T
K
E
IRNA
101
HHSearch
96.62
58%
-133
- C5 -
1JKX
1
PUR3_ECOLI
A:
[1-209]
----
M
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
C
K
T
N
K
I
K
G
T
V
R
A
V
F
S
N
K
A
D
A
F
G
L
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
A
F
D
S
R
E
A
Y
D
R
E
L
I
H
E
I
D
M
Y
A
P
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
A
A
W
L
D
G
Q
R
L
P
P
-
Q
G
Y
A
---------
7
PsiBlast_PDB
96.41
58%
-130
- C5 -
1CDE
2
PUR3_ECOLI
A:
[2-208]
-----
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
C
K
T
N
K
I
K
G
T
V
R
A
V
F
S
N
K
A
D
A
F
G
L
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
A
F
D
S
R
E
A
Y
D
R
E
L
I
H
E
I
D
M
Y
A
P
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
A
A
W
L
D
G
Q
R
L
-
P
P
Q
G
Y
A
---------
6
PsiBlast_PDB
96.40
58%
-131
- C5 -
1JKX
1
PUR3_ECOLI
A:
[2-208]
-----
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
C
K
T
N
K
I
K
G
T
V
R
A
V
F
S
N
K
A
D
A
F
G
L
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
A
F
D
S
R
E
A
Y
D
R
E
L
I
H
E
I
D
M
Y
A
P
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
A
A
W
L
D
G
Q
R
L
-
P
P
Q
G
Y
A
---------
26
PsiBlast_CBE
96.29
58%
-130
- C5 -
1CDE
2
PUR3_ECOLI
D:
[2-208]
-----
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
C
K
T
N
K
I
K
G
T
V
R
A
V
F
S
N
K
A
D
A
F
G
L
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
A
F
D
S
R
E
A
Y
D
R
E
L
I
H
E
I
D
M
Y
A
P
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
A
A
W
L
D
G
Q
R
L
-
P
P
Q
G
Y
A
---------
23
PsiBlast_CBE
96.29
58%
-129
- C5 -
1JKX
1
PUR3_ECOLI
B:
[2-208]
-----
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
C
K
T
N
K
I
K
G
T
V
R
A
V
F
S
N
K
A
D
A
F
G
L
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
A
F
D
S
R
E
A
Y
D
R
E
L
I
H
E
I
D
M
Y
A
P
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
A
A
W
L
D
G
Q
R
L
-
P
P
Q
G
Y
A
---------
21
PsiBlast_CBE
96.22
58%
-133
- C5 -
1JKX
1
PUR3_ECOLI
D:
[2-208]
-----
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
C
K
T
N
K
I
K
G
T
V
R
A
V
F
S
N
K
A
D
A
F
G
L
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
A
F
D
S
R
E
A
Y
D
R
E
L
I
H
E
I
D
M
Y
A
P
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
A
A
W
L
D
G
Q
R
L
-
P
P
Q
G
Y
A
---------
28
PsiBlast_CBE
96.21
58%
-130
- C5 -
1CDE
2
PUR3_ECOLI
B:
[2-208]
-----
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
C
K
T
N
K
I
K
G
T
V
R
A
V
F
S
N
K
A
D
A
F
G
L
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
A
F
D
S
R
E
A
Y
D
R
E
L
I
H
E
I
D
M
Y
A
P
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
A
A
W
L
D
G
Q
R
L
-
P
P
Q
G
Y
A
---------
27
PsiBlast_CBE
96.14
58%
-130
- C5 -
1CDE
2
PUR3_ECOLI
C:
[2-208]
-----
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
C
K
T
N
K
I
K
G
T
V
R
A
V
F
S
N
K
A
D
A
F
G
L
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
A
F
D
S
R
E
A
Y
D
R
E
L
I
H
E
I
D
M
Y
A
P
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
A
A
W
L
D
G
Q
R
L
-
P
P
Q
G
Y
A
---------
30
PsiBlast_CBE
96.04
58%
-132
- C5 -
1C2T
2
PUR3_ECOLI
B:
[2-208]
-----
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
C
K
T
N
K
I
K
G
T
V
R
A
V
F
S
N
K
A
D
A
F
G
L
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
A
F
D
S
R
E
A
Y
D
R
E
L
I
H
E
I
D
M
Y
A
P
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
A
A
W
L
D
G
Q
R
L
-
P
P
Q
G
Y
A
---------
22
PsiBlast_CBE
95.91
58%
-128
- C5 -
1JKX
1
PUR3_ECOLI
C:
[2-208]
-----
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
C
K
T
N
K
I
K
G
T
V
R
A
V
F
S
N
K
A
D
A
F
G
L
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
A
F
D
S
R
E
A
Y
D
R
E
L
I
H
E
I
D
M
Y
A
P
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
A
A
W
L
D
G
Q
R
L
-
P
P
Q
G
Y
A
---------
31
PsiBlast_CBE
95.87
58%
-132
- C5 -
1C3E
2
PUR3_ECOLI
B:
[2-208]
-----
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
C
K
T
N
K
I
K
G
T
V
R
A
V
F
S
N
K
A
D
A
F
G
L
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
A
F
D
S
R
E
A
Y
D
R
E
L
I
H
E
I
D
M
Y
A
P
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
A
A
W
L
D
G
Q
R
L
-
P
P
Q
G
Y
A
---------
9
PsiBlast_PDB
95.24
58%
-133
- C5 -
1C3E
2
PUR3_ECOLI
A:
[2-208]
-----
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
C
K
T
N
K
I
K
G
T
V
R
A
V
F
S
N
K
A
D
A
F
G
L
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
A
F
D
S
R
E
A
Y
D
R
E
L
I
H
E
I
D
M
Y
A
P
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
A
A
W
L
D
G
Q
R
L
-
P
P
Q
G
Y
A
---------
5
PsiBlast_PDB
94.95
58%
-132
- C5 -
1C2T
2
PUR3_ECOLI
A:
[2-208]
-----
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
C
K
T
N
K
I
K
G
T
V
R
A
V
F
S
N
K
A
D
A
F
G
L
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
A
F
D
S
R
E
A
Y
D
R
E
L
I
H
E
I
D
M
Y
A
P
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
A
A
W
L
D
G
Q
R
L
-
P
P
Q
G
Y
A
---------
2
PsiBlast_PDB
94.15
59%
-127
- C5 -
3GAR
1
PUR3_ECOLI
A:
[2-208]
-----
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
C
K
T
N
K
I
K
G
T
V
R
A
V
F
S
N
K
A
D
A
F
G
L
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
A
F
D
S
R
E
A
Y
D
R
A
L
I
H
E
I
D
M
Y
A
P
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
A
A
W
L
D
G
Q
R
L
-
P
P
Q
G
Y
A
---------
10
PsiBlast_PDB
93.88
54%
-131
- C5 -
3TQR
1
?
A:
[8-212]
------
I
V
V
L
I
S
G
N
G
T
N
L
Q
A
I
I
G
A
I
Q
K
G
L
A
-
I
E
I
R
A
V
I
S
N
R
A
D
A
Y
G
L
K
R
A
Q
Q
A
D
I
P
T
H
I
I
P
H
E
E
F
P
S
R
T
D
F
E
S
T
L
Q
K
T
I
D
H
Y
D
P
K
L
I
V
L
A
G
F
M
R
K
L
G
K
A
F
V
S
H
Y
S
G
R
M
I
N
I
H
P
S
L
L
P
K
Y
T
G
L
N
T
H
E
R
A
L
A
A
G
E
T
E
H
G
V
S
V
H
Y
V
T
-
D
L
D
A
G
P
L
I
C
Q
A
R
L
S
I
T
P
Q
D
T
P
E
T
L
K
T
R
V
H
A
L
E
H
I
I
Y
P
E
V
L
S
W
F
A
A
G
R
L
N
Y
H
N
N
Q
V
F
L
D
G
K
P
L
-
A
K
S
G
H
A
F
P
-------
8
PsiBlast_PDB
93.30
58%
-145
- C5 -
1CDD
1
PUR3_ECOLI
A:
[2-208]
-----
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
C
K
T
N
K
I
K
G
T
V
R
A
V
F
S
N
K
A
D
A
F
G
L
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
A
F
D
S
R
E
A
Y
D
R
E
L
I
H
E
I
D
M
Y
A
P
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
-----------------------
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
A
A
W
L
D
G
Q
R
L
-
P
P
Q
G
Y
A
A
D
E
------
29
PsiBlast_CBE
92.49
58%
-147
- C5 -
1CDD
1
PUR3_ECOLI
B:
[2-208]
-----
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
C
K
T
N
K
I
K
G
T
V
R
A
V
F
S
N
K
A
D
A
F
G
L
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
A
F
D
S
R
E
A
Y
D
R
E
L
I
H
E
I
D
M
Y
A
P
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
-----------------------
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
A
A
W
L
D
G
Q
R
L
-
P
P
Q
G
Y
A
A
D
E
------
1
PsiBlast_PDB
92.05
59%
-146
- C5 -
2GAR
1
PUR3_ECOLI
A:
[2-208]
-----
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
C
K
T
N
K
I
K
G
T
V
R
A
V
F
S
N
K
A
D
A
F
G
L
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
A
F
D
S
R
E
A
Y
D
R
A
L
I
H
E
I
D
M
Y
A
P
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
---------------------
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
A
A
W
L
D
G
Q
R
L
-
P
P
Q
G
Y
A
---------
14
PsiBlast_PDB
91.60
49%
-138
- C5 -
1MEO
2
A:
[3-197]
------
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
---
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
G
K
I
C
W
V
K
E
E
-
H
H
-------------
36
PsiBlast_CBE
91.19
49%
-133
- C5 -
4EW3
4
A:
[3-197]
------
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
G
K
I
C
W
V
K
E
E
-
H
H
-------------
50
PsiBlast_CBE
91.08
49%
-135
- C5 -
1RBM
4
B:
[3-197]
------
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
G
K
I
C
W
V
-------------------
48
PsiBlast_CBE
90.93
49%
-135
- C5 -
1RBQ
3
PUR2_HUMAN
C:
[3-197]
------
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
G
K
I
C
W
V
-------------------
41
PsiBlast_CBE
90.89
49%
-133
- C5 -
1RC1
2
PUR2_HUMAN
A:
[3-197]
------
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
G
K
I
C
W
V
-------------------
40
PsiBlast_CBE
90.85
49%
-136
- C5 -
1RC1
3
B:
[3-197]
------
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
G
K
I
C
W
V
-------------------
45
PsiBlast_CBE
90.79
49%
-134
- C5 -
1RBY
2
PUR2_HUMAN
C:
[3-197]
------
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
G
K
I
C
W
V
-------------------
47
PsiBlast_CBE
90.76
49%
-132
- C5 -
1RBQ
2
D:
[3-197]
------
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
G
K
I
C
W
V
-------------------
51
PsiBlast_CBE
90.60
49%
-136
- C5 -
1NJS
2
B:
[3-197]
------
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
G
K
I
C
W
V
-------------------
46
PsiBlast_CBE
90.54
49%
-132
- C5 -
1RBY
2
PUR2_HUMAN
B:
[3-197]
------
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
G
K
I
C
W
V
-------------------
49
PsiBlast_CBE
90.50
49%
-134
- C5 -
1RBQ
3
PUR2_HUMAN
B:
[3-197]
------
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
G
K
I
C
W
V
-------------------
42
PsiBlast_CBE
90.24
49%
-132
- C5 -
1RC0
1
B:
[3-197]
------
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
G
K
I
C
W
V
-------------------
44
PsiBlast_CBE
90.13
49%
-132
- C5 -
1RBY
1
D:
[3-197]
------
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
G
K
I
C
W
V
-------------------
43
PsiBlast_CBE
90.12
49%
-132
- C5 -
1RBZ
2
B:
[3-197]
------
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
G
K
I
C
W
V
-------------------
39
PsiBlast_CBE
89.14
49%
-131
- C5 -
1ZLY
2
A:
[3-197]
------
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
G
K
I
C
W
V
-------------------
52
PsiBlast_CBE
88.49
51%
-132
- C5 -
4DS3
5
?
A:
[10-204]
------
V
V
I
F
I
S
G
G
G
S
N
M
E
A
L
I
R
A
A
Q
A
P
G
F
P
A
E
I
V
A
V
F
S
D
K
A
E
A
G
G
L
A
K
A
E
A
A
G
I
A
T
Q
V
F
K
R
K
D
F
A
S
K
E
A
H
E
D
A
I
L
A
A
L
D
V
L
K
P
D
I
I
C
L
A
G
Y
M
R
L
L
S
G
R
F
I
A
P
Y
E
G
R
I
L
N
I
H
P
S
L
L
P
L
F
P
G
L
H
T
H
Q
R
A
L
D
A
G
M
K
L
A
G
C
T
V
H
L
V
T
E
--
D
E
G
P
I
L
A
Q
A
A
V
P
V
L
D
G
D
T
A
E
T
L
A
A
R
V
L
K
A
E
H
R
L
Y
P
L
A
L
Q
K
F
A
A
G
M
V
L
S
A
---------------------------
55
PsiBlast_CBE
83.34
41%
-135
- C5 -
3KCQ
1
?
B:
[7-200]
--
K
E
L
R
V
G
V
L
I
S
G
R
G
S
N
L
E
A
L
A
K
A
F
S
T
---
S
V
V
I
S
C
V
I
S
N
N
A
E
A
R
G
L
L
I
A
Q
S
Y
G
I
P
T
F
V
V
K
R
K
P
L
-
D
I
E
H
I
S
T
V
L
R
E
----
H
D
V
D
L
V
C
L
A
G
F
M
S
I
L
P
E
K
F
V
T
D
W
H
H
K
I
I
N
I
H
P
S
L
L
P
S
F
K
G
L
N
A
Q
E
Q
A
Y
K
A
G
V
K
I
A
G
C
T
L
H
Y
V
Y
Q
E
L
D
A
G
P
I
I
M
Q
A
A
V
P
V
L
R
E
D
T
A
E
S
L
A
S
R
I
L
A
A
E
H
V
C
Y
P
K
G
V
K
L
I
A
Q
D
K
I
K
L
C
D
D
G
T
V
Q
C
T
G
E
D
-
E
L
F
L
F
Q
E
--------
53
PsiBlast_CBE
82.47
41%
-136
* C5 *
3KCQ
1
?
D:
[7-200]
--
K
E
L
R
V
G
V
L
I
S
G
R
G
S
N
L
E
A
L
A
K
A
F
S
---
S
S
V
V
I
S
C
V
I
S
N
N
A
E
A
R
G
L
L
I
A
Q
S
Y
G
I
P
T
F
V
V
K
R
K
P
L
-
D
I
E
H
I
S
T
V
L
R
E
----
H
D
V
D
L
V
C
L
A
G
F
M
S
I
L
P
E
K
F
V
T
D
W
H
H
K
I
I
N
I
H
P
S
L
L
P
S
F
K
G
L
N
A
Q
E
Q
A
Y
K
A
G
V
K
I
A
G
C
T
L
H
Y
V
Y
Q
E
L
D
A
G
P
I
I
M
Q
A
A
V
P
V
L
R
E
D
T
A
E
S
L
A
S
R
I
L
A
A
E
H
V
C
Y
P
K
G
V
K
L
I
A
Q
D
K
I
K
L
C
D
D
G
T
V
Q
C
T
G
E
D
-
E
L
F
L
F
Q
E
--------
54
PsiBlast_CBE
82.42
41%
-131
- C5 -
3KCQ
1
?
C:
[7-200]
--
K
E
L
R
V
G
V
L
I
S
G
R
G
S
N
L
E
A
L
A
K
A
F
S
T
E
E
S
S
V
V
I
S
C
V
I
S
N
N
A
E
A
R
G
L
L
I
A
Q
S
Y
G
I
P
T
F
V
V
K
R
K
P
L
-
D
I
E
H
I
S
T
V
L
R
E
----
H
D
V
D
L
V
C
L
A
G
F
M
S
I
L
P
E
K
F
V
T
D
W
H
H
K
I
I
N
I
H
P
S
L
L
P
S
F
K
G
L
N
A
Q
E
Q
A
Y
K
A
G
V
K
I
A
G
C
T
L
H
Y
V
Y
Q
E
L
D
A
G
P
I
I
M
Q
A
A
V
P
V
L
R
E
D
T
A
E
S
L
A
S
R
I
L
A
A
E
H
V
C
Y
P
K
G
V
K
L
I
A
Q
D
K
I
K
L
C
D
D
G
T
V
Q
C
T
G
E
D
-
E
L
F
L
F
Q
E
N
F
------
56
PsiBlast_CBE
82.39
41%
-134
- C5 -
3KCQ
1
?
A:
[7-200]
--
K
E
L
R
V
G
V
L
I
S
G
R
G
S
N
L
E
A
L
A
K
A
F
S
T
-
E
S
S
V
V
I
S
C
V
I
S
N
N
A
E
A
R
G
L
L
I
A
Q
S
Y
G
I
P
T
F
V
V
K
R
K
P
L
-
D
I
E
H
I
S
T
V
L
R
E
----
H
D
V
D
L
V
C
L
A
G
F
M
S
I
L
P
E
K
F
V
T
D
W
H
H
K
I
I
N
I
H
P
S
L
L
P
S
F
K
G
L
N
A
Q
E
Q
A
Y
K
A
G
V
K
I
A
G
C
T
L
H
Y
V
Y
Q
E
L
D
A
G
P
I
I
M
Q
A
A
V
P
V
L
R
E
D
T
A
E
S
L
A
S
R
I
L
A
A
E
H
V
C
Y
P
K
G
V
K
L
I
A
Q
D
K
I
K
L
C
D
D
G
T
V
Q
C
T
G
E
D
-
E
L
F
L
F
Q
E
N
-------
103
HHSearch
81.08
41%
-133
- C5 -
3KCQ
1
?
A:
[7-202]
--
K
E
L
R
V
G
V
L
I
S
G
R
G
S
N
L
E
A
L
A
K
A
F
S
T
-
E
S
S
V
V
I
S
C
V
I
S
N
N
A
E
A
R
G
L
L
I
A
Q
S
Y
G
I
P
T
F
V
V
K
R
K
-----
P
L
D
I
E
H
I
S
T
V
L
R
E
H
D
V
D
L
V
C
L
A
G
F
M
S
I
L
P
E
K
F
V
T
D
W
H
H
K
I
I
N
I
H
P
S
L
L
P
S
F
K
G
L
N
A
Q
E
Q
A
Y
K
A
G
V
K
I
A
G
C
T
L
H
Y
V
Y
Q
E
L
D
A
G
P
I
I
M
Q
A
A
V
P
V
L
R
E
D
T
A
E
S
L
A
S
R
I
L
A
A
E
H
V
C
Y
P
K
G
V
K
L
I
A
Q
D
K
I
K
L
C
D
D
G
T
V
Q
C
T
G
E
D
-
E
L
F
L
F
Q
E
N
-------