@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0963: (2016-01-25 )
MMRSHYCGQLNESLDGQEVTLCGWVHRRRDHGGVIFLDVRDREGLAQVVFDPDRAETFAKADRVRSEFVVKITGKVRLRPEGARNPNMASGSIEVLGYELEVLNQAETPPFPLDEYSDVGEETRLRYRFIDLRRPEMAAKLKLRARITSSIRRYLDDNGFLDVETPILGRPTPEGARDYLVPSRTYPGHFFALPQSPQLFKQLLMVAGFDRYYQIAKCFRDEDLRADRQPEFTQIDIETSFLDESDIIGITEKMVRQLFKEVLDVEFDEFPHMPFEEAMRRYGSDKPDLRIPLELVDVADQLKEVEFKVFSGPANDPKGRVAALRVPGAASMPRSQIDDYTKFVGIYGAKGLAYIKVNERAKGVEGLQSPIVKFIPEANLNVILDRVGAVDGDIVFFGADKAKIVCDALGALRIKVGHDLKLLTREWAPMWVVDFPMFEENDDGSLSALHHPFTSPKCTPAELEANPGAALSRAYDMVLNGTELGGGSIRIHDKSMQQAVFRVLGIDEAEQEEKFGFLLDALKYGAPPHGGLAFGLDRLVMLMTGASSIREVIAFPKTQSAGDVMTQAPGSVDGKALRELHIRLREQPKAE
Atome Classification :
(20 SA)
.........10........20........30........40........50...--.....60.....--...70........80........90........100....-...110..------..------...120.......130.......140.......150.....-..160.......170.......180.......190.......200.......210.......220.......-230.......240-.......250.......260-....-------------..-.270.......280.......290.......300.......310.......320.....-..330.......340.......350.......360.......370.......380.......390.......400.......410.......420--...-.-.---...430......--.-440-.-----------......450.....-..-460-.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MMRSHYCGQLNESLDG
Q
E
V
T
L
C
G
W
V
H
RRRDHG
G
V
I
F
L
DVRDREG
L
A
Q
V
V
FDP
D
R
--
A
E
T
F
A
K
A
D
RVR
S
--
E
F
V
V
K
I
T
G
K
V
R
LRPEGARNPNMASG
S
I
E
V
L
G
Y
E
L
E
VLNQA-ETPPFP
L
D
------
E
Y
------SDV
G
E
E
T
R
L
R
Y
R
F
I
DLRRP
E
M
A
A
K
L
K
L
R
A
R
I
T
S
S
I
R
R
Y
LDD-NG
F
L
DVETPILGRPTPEGARDYLVPSRTYPG
H
F
F
ALPQ
S
P
Q
L
F
K
Q
L
L
M
VAG
F
D
R
Y
Y
Q
I
A
K
C
F
R
DEDLRADRQ-PE
F
T
Q
I
D
I
E
T
SFL-DESD
I
I
G
I
T
E
K
M
V
R
Q
L
F
K
E
V
-LDV
E
-------------
F
D
-EFPHM
P
F
E
E
A
M
R
RYGSDKPD
L
R
I
P
L
E
L
V
D
V
A
D
Q
L
K
E
V
E
F
K
V
FSGPANDPKG
R
V
A
A
L
RVP-GAASM
P
R
S
Q
I
D
D
Y
T
K
F
V
G
IYGAK
G
L
A
Y
I
K
VNERAKG
V
E
G
L
Q
S
P
I
V
K
FIPEA
N
L
N
V
I
L
D
RVGAVDG
D
I
V
F
FGAD
K
A
K
I
V
C
D
AL
G
A
L
R
I
KVGHD
L
K
---
L
L
T
-R-E---WA
P
M
W
V
V
DFPMF--E-END-D-----------GS
L
S
A
LHHPFTSPK-CT-PAE-LEANPG
A
A
L
S
R
A
Y
D
M
V
LN
G
T
ELGG
G
S
I
R
I
H
D
K
S
M
Q
Q
A
V
F
R
V
LGID
E
A
E
Q
E
E
K
F
G
F
L
L
D
A
L
KYGAPPHG
G
L
A
F
G
L
D
R
L
V
M
L
MT
G
A
S
S
I
R
E
V
I
AFPKTQSAGDVMTQAPGSV
D
G
K
A
L
R
E
L
H
I
R
L
REQPKAE
1
PsiBlast_PDB
95.70
100%
-108
- C7 -
4WJ3
-
SYDND_PSEAE
M:
[10-598]
-
M
R
S
H
Y
C
G
Q
L
N
E
S
L
D
G
Q
E
V
T
L
C
G
W
V
H
R
R
R
D
H
G
G
V
I
F
L
D
V
R
D
R
E
G
L
A
Q
V
V
F
D
P
D
R
--
A
E
T
F
A
K
A
D
R
V
R
S
--
E
F
V
V
K
I
T
G
K
V
R
L
R
P
E
G
A
R
N
P
N
M
A
S
G
S
I
E
V
L
G
Y
E
L
E
V
L
N
Q
A
-
E
T
P
P
F
P
L
D
------
E
Y
------
S
D
V
G
E
E
T
R
L
R
Y
R
F
I
D
L
R
R
P
E
M
A
A
K
L
K
L
R
A
R
I
T
S
S
I
R
R
Y
L
D
D
-
N
G
F
L
D
V
E
T
P
I
L
G
R
P
T
P
E
G
A
R
D
Y
L
V
P
S
R
T
Y
P
G
H
F
F
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
F
D
R
Y
Y
Q
I
A
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
I
E
T
S
F
L
-
D
E
S
D
I
I
G
I
T
E
K
M
V
R
Q
L
F
K
E
V
-
L
D
V
E
-------------
F
D
-
E
F
P
H
M
P
F
E
E
A
M
R
R
Y
G
S
D
K
P
D
L
R
I
P
L
E
L
V
D
V
A
D
Q
L
K
E
V
E
F
K
V
F
S
G
P
A
N
D
P
K
G
R
V
A
A
L
R
V
P
-
G
A
A
S
M
P
R
S
Q
I
D
D
Y
T
K
F
V
G
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
R
A
K
G
V
E
G
L
Q
S
P
I
V
K
F
I
P
E
A
N
L
N
V
I
L
D
R
V
G
A
V
D
G
D
I
V
F
F
G
A
D
K
A
K
I
V
C
D
A
L
G
A
L
R
I
K
V
G
H
D
L
K
---
L
L
T
-
R
-
E
---
W
A
P
M
W
V
V
D
F
P
M
F
--
E
-
E
N
D
-
D
-----------
G
S
L
S
A
L
H
H
P
F
T
S
P
K
-
C
T
-
P
A
E
-
L
E
A
N
P
G
A
A
L
S
R
A
Y
D
M
V
L
N
G
T
E
L
G
G
G
S
I
R
I
H
D
K
S
M
Q
Q
A
V
F
R
V
L
G
I
D
E
A
E
Q
E
E
K
F
G
F
L
L
D
A
L
K
Y
G
A
P
P
H
G
G
L
A
F
G
L
D
R
L
V
M
L
M
T
G
A
S
S
I
R
E
V
I
A
F
P
K
T
Q
S
A
G
D
V
M
T
Q
A
P
G
S
V
D
G
K
A
L
R
E
L
H
I
R
L
R
E
Q
P
K
A
-
2
PsiBlast_PDB
94.42
100%
-106
- C7 -
4WJ4
1
SYDND_PSEAE
A:
[10-594]
-
M
R
S
H
Y
C
G
Q
L
N
E
S
L
D
G
Q
E
V
T
L
C
G
W
V
H
R
R
R
D
H
G
G
V
I
F
L
D
V
R
D
R
E
G
L
A
Q
V
V
F
D
P
D
R
--
A
E
T
F
A
K
A
D
R
V
R
S
--
E
F
V
V
K
I
T
G
K
V
R
L
R
P
E
G
A
R
N
P
N
M
A
S
G
S
I
E
V
L
G
Y
E
L
E
V
L
N
Q
A
-
E
T
P
P
F
P
L
D
------
E
Y
------
S
D
V
G
E
E
T
R
L
R
Y
R
F
I
D
L
R
R
P
E
M
A
A
K
L
K
L
R
A
R
I
T
S
S
I
R
R
Y
L
D
D
-
N
G
F
L
D
V
E
T
P
I
L
G
R
P
T
P
E
G
A
R
D
Y
L
V
P
S
R
T
Y
P
G
H
F
F
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
F
D
R
Y
Y
Q
I
A
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
I
E
T
S
F
L
-
D
E
S
D
I
I
G
I
T
E
K
M
V
R
Q
L
F
K
E
V
-
L
D
V
E
-------------
F
D
-
E
F
P
H
M
P
F
E
E
A
M
R
R
Y
G
S
D
K
P
D
L
R
I
P
L
E
L
V
D
V
A
D
Q
L
K
E
V
E
F
K
V
F
S
G
P
A
N
D
P
K
G
R
V
A
A
L
R
V
P
-
G
A
A
S
M
P
R
S
Q
I
D
D
Y
T
K
F
V
G
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
R
A
K
G
V
E
G
L
Q
S
P
I
V
K
F
I
P
E
A
N
L
N
V
I
L
D
R
V
G
A
V
D
G
D
I
V
F
F
G
A
D
K
A
K
I
V
C
D
A
L
G
A
L
R
I
K
V
G
H
D
L
K
---
L
L
T
-
R
-
E
---
W
A
P
M
W
V
V
D
F
P
M
F
--
E
-
E
N
D
-
D
-----------
G
S
L
S
A
L
H
H
P
F
T
S
P
K
-
C
T
-
P
A
E
-
L
E
A
N
P
G
A
A
L
S
R
A
Y
D
M
V
L
N
G
T
E
L
G
G
G
S
I
R
I
H
D
K
S
M
Q
Q
A
V
F
R
V
L
G
I
D
E
A
E
Q
E
E
K
F
G
F
L
L
D
A
L
K
Y
G
A
P
P
H
G
G
L
A
F
G
L
D
R
L
V
M
L
M
T
G
A
S
S
I
R
E
V
I
A
F
P
K
T
Q
S
A
G
D
V
M
T
Q
A
P
G
S
V
D
G
K
A
L
R
E
L
H
I
R
L
R
E
-----
5
PsiBlast_PDB
86.74
64%
-96
- C7 -
1C0A
2
SYD_ECOLI
A:
[1-583]
-
M
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
D
P
D
R
--
A
D
A
L
K
L
A
S
E
L
R
N
--
E
F
C
I
Q
V
T
G
T
V
R
A
R
D
E
K
N
I
N
R
D
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
-
D
V
--
L
P
L
D
------
S
N
------
H
V
N
T
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
-
H
G
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
E
V
-
K
G
V
D
-------------
L
G
-
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
G
P
A
N
D
P
K
G
R
V
A
A
L
R
V
P
-
G
G
A
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
K
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
R
A
K
G
L
E
G
I
N
S
P
V
A
K
F
L
N
A
E
I
I
E
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
G
---
L
T
D
-
E
S
K
---
W
A
P
L
W
V
I
D
F
P
M
F
--
E
-
D
D
G
-
E
-----------
G
G
L
T
A
M
H
H
P
F
T
S
P
K
D
M
T
-
A
A
E
-
L
K
A
A
P
E
N
A
V
A
N
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
-----
3
PsiBlast_PDB
86.23
64%
-98
- C7 -
1EQR
1
SYD_ECOLI
A:
[1-583]
-
M
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
D
P
D
R
--
A
D
A
L
K
L
A
S
E
L
R
N
--
E
F
C
I
Q
V
T
G
T
V
R
A
R
D
E
K
N
I
N
R
D
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
-
D
V
--
L
P
L
D
------
S
N
------
H
V
N
T
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
-
H
G
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
E
V
-
K
G
V
D
-------------
L
G
-
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
G
P
A
N
D
P
K
G
R
V
A
A
L
R
V
P
-
G
G
A
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
K
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
R
A
K
G
L
E
G
I
N
S
P
V
A
K
F
L
N
A
E
I
I
E
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
G
---
L
T
D
-
E
S
K
---
W
A
P
L
W
V
I
D
F
P
M
F
--
E
-
D
D
G
-
E
-----------
G
G
L
T
A
M
H
H
P
F
T
S
P
K
D
M
T
-
A
A
E
-
L
K
A
A
P
E
N
A
V
A
N
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
K
A
E
N
N
62
Fugue
86.17
63%
-96
- C7 -
1C0A
2
SYD_ECOLI
A:
[1-585]
-
M
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
D
P
D
R
--
A
D
A
L
K
L
A
S
E
L
R
N
--
E
F
C
I
Q
V
T
G
T
V
R
A
R
D
E
K
N
I
N
R
D
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
-
D
V
L
P
L
D
S
N
------
H
V
------
N
T
--
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
-
H
G
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
E
V
-
K
G
V
D
-------------
L
G
-
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
G
P
A
N
D
P
K
G
R
V
A
A
L
R
V
P
-
G
G
A
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
K
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
R
A
K
G
L
E
G
I
N
S
P
V
A
K
F
L
N
A
E
I
I
E
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
G
---
L
T
D
-
E
-
S
K
--
W
A
P
L
W
V
I
D
F
P
M
F
--
E
-
D
D
G
-
E
-----------
G
G
L
T
A
M
H
H
P
F
T
S
P
K
D
M
T
-
A
A
E
-
L
K
A
A
P
E
N
A
V
A
N
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
-----
4
PsiBlast_PDB
86.12
64%
-100
- C7 -
1IL2
2
SYD_ECOLI
A:
[1-583]
-
M
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
D
P
D
R
--
A
D
A
L
K
L
A
S
E
L
R
N
--
E
F
C
I
Q
V
T
G
T
V
R
A
R
D
E
K
N
I
N
R
D
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
-
D
V
--
L
P
L
D
------
S
N
------
H
V
N
T
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
-
H
G
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
E
V
-
K
G
V
D
-------------
L
G
-
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
G
P
A
N
D
P
K
G
R
V
A
A
L
R
V
P
-
G
G
A
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
K
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
R
A
K
G
L
E
G
I
N
S
P
V
A
K
F
L
N
A
E
I
I
E
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
G
---
L
T
D
-
E
S
K
---
W
A
P
L
W
V
I
D
F
P
M
F
--
E
-
D
D
G
-
E
-----------
G
G
L
T
A
M
H
H
P
F
T
S
P
K
D
M
T
-
A
A
E
-
L
K
A
A
P
E
N
A
V
A
N
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
-----
23
PsiBlast_CBE
85.74
64%
-100
- C7 -
1EQR
1
SYD_ECOLI
B:
[1-583]
-
M
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
D
P
D
R
--
A
D
A
L
K
L
A
S
E
L
R
N
--
E
F
C
I
Q
V
T
G
T
V
R
A
R
D
E
K
N
I
N
R
D
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
-
D
V
--
L
P
L
D
------
S
N
------
H
V
N
T
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
-
H
G
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
E
V
-
K
G
V
D
-------------
L
G
-
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
G
P
A
N
D
P
K
G
R
V
A
A
L
R
V
P
-
G
G
A
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
K
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
R
A
K
G
L
E
G
I
N
S
P
V
A
K
F
L
N
A
E
I
I
E
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
G
---
L
T
D
-
E
S
K
---
W
A
P
L
W
V
I
D
F
P
M
F
--
E
-
D
D
G
-
E
-----------
G
G
L
T
A
M
H
H
P
F
T
S
P
K
D
M
T
-
A
A
E
-
L
K
A
A
P
E
N
A
V
A
N
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
K
A
E
N
N
21
PsiBlast_CBE
85.62
64%
-96
- C7 -
1IL2
2
SYD_ECOLI
B:
[1-583]
-
M
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
D
P
D
R
--
A
D
A
L
K
L
A
S
E
L
R
N
--
E
F
C
I
Q
V
T
G
T
V
R
A
R
D
E
K
N
I
N
R
D
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
-
D
V
--
L
P
L
D
------
S
N
------
H
V
N
T
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
-
H
G
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
E
V
-
K
G
V
D
-------------
L
G
-
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
G
P
A
N
D
P
K
G
R
V
A
A
L
R
V
P
-
G
G
A
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
K
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
R
A
K
G
L
E
G
I
N
S
P
V
A
K
F
L
N
A
E
I
I
E
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
G
---
L
T
D
-
E
S
K
---
W
A
P
L
W
V
I
D
F
P
M
F
--
E
-
D
D
G
-
E
-----------
G
G
L
T
A
M
H
H
P
F
T
S
P
K
D
M
T
-
A
A
E
-
L
K
A
A
P
E
N
A
V
A
N
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
-----
22
PsiBlast_CBE
84.71
64%
-98
- C7 -
1EQR
1
SYD_ECOLI
C:
[1-583]
-
M
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
D
P
D
R
--
A
D
A
L
K
L
A
S
E
L
R
N
--
E
F
C
I
Q
V
T
G
T
V
R
A
R
D
E
K
N
I
N
R
D
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
-
D
V
--
L
P
L
D
------
S
N
------
H
V
N
T
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
-
H
G
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
E
V
-
K
G
V
D
-------------
L
G
-
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
G
P
A
N
D
P
K
G
R
V
A
A
L
R
V
P
-
G
G
A
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
K
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
R
A
K
G
L
E
G
I
N
S
P
V
A
K
F
L
N
A
E
I
I
E
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
G
---
L
T
D
-
E
S
K
---
W
A
P
L
W
V
I
D
F
P
M
F
--
E
-
D
D
G
-
E
-----------
G
G
L
T
A
M
H
H
P
F
T
S
P
K
D
M
T
-
A
A
E
-
L
K
A
A
P
E
N
A
V
A
N
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
K
A
E
N
N
42
HHSearch
80.64
52%
-97
- C7 -
1L0W
-
SYD_THETH
A:
[1-579]
M
R
R
T
H
Y
A
G
S
L
R
E
T
H
V
G
E
E
V
V
L
E
G
W
V
N
R
R
R
D
L
G
G
L
I
F
L
D
L
R
D
R
E
G
L
V
Q
L
V
A
H
P
A
S
---
P
A
Y
A
T
A
E
R
V
R
P
--
E
W
V
V
R
A
K
G
L
V
R
L
R
P
E
P
--
N
P
R
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
-
K
T
P
P
F
P
V
D
------
A
G
WRG
E
E
E
K
E
A
S
E
E
L
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
R
L
R
H
R
V
I
K
A
I
W
D
F
L
D
R
-
E
G
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
M
V
A
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
D
F
T
Q
L
D
L
E
M
S
F
V
-
E
V
E
D
V
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
-
L
G
V
E
-------------
L
P
L
P
F
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
L
E
L
K
E
V
G
P
L
F
R
Q
S
G
F
R
V
F
Q
E
A
-----
E
S
V
K
A
L
A
L
P
-
K
--
A
L
S
R
K
E
V
A
E
L
E
E
V
A
K
R
H
K
A
Q
G
L
A
W
A
R
V
E
E
G
-----
G
F
S
G
G
V
A
K
F
L
E
P
-
V
R
E
A
L
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
G
A
V
R
L
R
A
A
D
L
L
G
---
L
K
R
-
E
-
G
---
F
R
F
L
W
V
V
D
F
P
L
L
--
E
-
W
D
E
E
E
-----------
E
A
W
T
Y
M
H
H
P
F
T
S
P
H
-
P
E
D
L
P
L
-
L
E
K
D
P
G
R
V
R
A
L
A
Y
D
L
V
L
N
G
V
E
V
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
A
P
S
P
V
P
E
E
Q
L
R
E
L
G
L
M
V
V
R
P
----
10
PsiBlast_PDB
80.12
50%
-98
- C7 -
1L0W
-
SYD_THETH
A:
[1-575]
M
R
R
T
H
Y
A
G
S
L
R
E
T
H
V
G
E
E
V
V
L
E
G
W
V
N
R
R
R
D
L
G
G
L
I
F
L
D
L
R
D
R
E
G
L
V
Q
L
V
A
H
P
A
---
S
P
A
Y
A
T
A
E
R
V
R
P
--
E
W
V
V
R
A
K
G
L
V
R
L
R
P
E
P
--
N
P
R
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
-
K
T
P
P
F
P
V
D
AGWRG
E
E
E
------
K
E
A
S
E
E
L
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
R
L
R
H
R
V
I
K
A
I
W
D
F
L
D
R
-
E
G
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
M
V
A
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
D
F
T
Q
L
D
L
E
M
S
F
V
-
E
V
E
D
V
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
-
L
G
V
E
-------------
L
P
L
P
F
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
L
E
L
K
E
V
G
P
L
F
R
Q
S
G
F
R
V
F
Q
E
A
E
S
-----
V
K
A
L
A
L
P
-
K
A
L
S
--
R
K
E
V
A
E
L
E
E
V
A
K
R
H
K
A
Q
G
L
A
W
A
R
V
E
E
-----
G
G
F
S
G
G
V
A
K
F
L
-
E
P
V
R
E
A
L
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
G
A
V
R
L
R
A
A
D
L
L
G
---
L
K
R
-
E
-
G
---
F
R
F
L
W
V
V
D
F
P
L
L
--
E
W
D
E
E
-
E
-----------
E
A
W
T
Y
M
H
H
P
F
T
S
P
H
-
P
E
-
D
L
P
L
L
E
K
D
P
G
R
V
R
A
L
A
Y
D
L
V
L
N
G
V
E
V
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
A
P
S
P
V
P
E
E
Q
L
R
E
L
G
L
M
V
V
R
P
----
9
PsiBlast_PDB
79.88
50%
-98
- C7 -
1G51
2
SYD_THETH
A:
[1-575]
M
R
R
T
H
Y
A
G
S
L
R
E
T
H
V
G
E
E
V
V
L
E
G
W
V
N
R
R
R
D
L
G
G
L
I
F
L
D
L
R
D
R
E
G
L
V
Q
L
V
A
H
P
A
---
S
P
A
Y
A
T
A
E
R
V
R
P
--
E
W
V
V
R
A
K
G
L
V
R
L
R
P
E
P
--
N
P
R
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
-
K
T
P
P
F
P
V
D
AGWRG
E
E
E
------
K
E
A
S
E
E
L
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
R
L
R
H
R
V
I
K
A
I
W
D
F
L
D
R
-
E
G
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
M
V
A
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
D
F
T
Q
L
D
L
E
M
S
F
V
-
E
V
E
D
V
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
-
L
G
V
E
-------------
L
P
L
P
F
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
L
E
L
K
E
V
G
P
L
F
R
Q
S
G
F
R
V
F
Q
E
A
E
S
-----
V
K
A
L
A
L
P
-
K
A
L
S
--
R
K
E
V
A
E
L
E
E
V
A
K
R
H
K
A
Q
G
L
A
W
A
R
V
E
E
-----
G
G
F
S
G
G
V
A
K
F
L
-
E
P
V
R
E
A
L
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
G
A
V
R
L
R
A
A
D
L
L
G
---
L
K
R
-
E
-
G
---
F
R
F
L
W
V
V
D
F
P
L
L
--
E
W
D
E
E
-
E
-----------
E
A
W
T
Y
M
H
H
P
F
T
S
P
H
-
P
E
-
D
L
P
L
L
E
K
D
P
G
R
V
R
A
L
A
Y
D
L
V
L
N
G
V
E
V
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
A
P
S
P
V
P
E
E
Q
L
R
E
L
G
L
M
V
V
R
P
----
25
PsiBlast_CBE
79.50
50%
-97
- C7 -
1G51
3
SYD_THETH
B:
[1-575]
M
R
R
T
H
Y
A
G
S
L
R
E
T
H
V
G
E
E
V
V
L
E
G
W
V
N
R
R
R
D
L
G
G
L
I
F
L
D
L
R
D
R
E
G
L
V
Q
L
V
A
H
P
A
---
S
P
A
Y
A
T
A
E
R
V
R
P
--
E
W
V
V
R
A
K
G
L
V
R
L
R
P
E
P
--
N
P
R
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
-
K
T
P
P
F
P
V
D
AGWRGE
E
E
------
K
E
A
S
E
E
L
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
R
L
R
H
R
V
I
K
A
I
W
D
F
L
D
R
-
E
G
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
M
V
A
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
D
F
T
Q
L
D
L
E
M
S
F
V
-
E
V
E
D
V
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
-
L
G
V
E
-------------
L
P
L
P
F
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
L
E
L
K
E
V
G
P
L
F
R
Q
S
G
F
R
V
F
Q
E
A
E
S
-----
V
K
A
L
A
L
P
-
K
A
L
S
--
R
K
E
V
A
E
L
E
E
V
A
K
R
H
K
A
Q
G
L
A
W
A
R
V
E
E
-----
G
G
F
S
G
G
V
A
K
F
L
-
E
P
V
R
E
A
L
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
G
A
V
R
L
R
A
A
D
L
L
G
---
L
K
R
-
E
-
G
---
F
R
F
L
W
V
V
D
F
P
L
L
--
E
W
D
E
E
-
E
-----------
E
A
W
T
Y
M
H
H
P
F
T
S
P
H
-
P
E
-
D
L
P
L
L
E
K
D
P
G
R
V
R
A
L
A
Y
D
L
V
L
N
G
V
E
V
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
A
P
S
P
V
P
E
E
Q
L
R
E
L
G
L
M
V
V
R
P
----
8
PsiBlast_PDB
79.15
50%
-99
- C7 -
1EFW
-
SYD_THETH
A:
[1-575]
M
R
R
T
H
Y
A
G
S
L
R
E
T
H
V
G
E
E
V
V
L
E
G
W
V
N
R
R
R
D
L
G
G
L
I
F
L
D
L
R
D
R
E
G
L
V
Q
L
V
A
H
P
A
---
S
P
A
Y
A
T
A
E
R
V
R
P
--
E
W
V
V
R
A
K
G
L
V
R
L
R
P
E
P
--
N
P
R
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
-
K
T
P
P
F
P
V
D
AGWRGE
E
E
------
K
E
A
S
E
E
L
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
R
L
R
H
R
V
I
K
A
I
W
D
F
L
D
R
-
E
G
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
M
V
A
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
D
F
T
Q
L
D
L
E
M
S
F
V
-
E
V
E
D
V
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
-
L
G
V
E
-------------
L
P
L
P
F
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
L
E
L
K
E
V
G
P
L
F
R
Q
S
G
F
R
V
F
Q
E
A
E
S
-----
V
K
A
L
A
L
P
-
K
A
L
S
--
R
K
E
V
A
E
L
E
E
V
A
K
R
H
K
A
Q
G
L
A
W
A
R
V
E
E
-----
G
G
F
S
G
G
V
A
K
F
L
-
E
P
V
R
E
A
L
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
G
A
V
R
L
R
A
A
D
L
L
G
---
L
K
R
-
E
-
G
---
F
R
F
L
W
V
V
D
F
P
L
L
--
E
W
D
E
E
-
E
-----------
E
A
W
T
Y
M
H
H
P
F
T
S
P
H
-
P
E
-
D
L
P
L
L
E
K
D
P
G
R
V
R
A
L
A
Y
D
L
V
L
N
G
V
E
V
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
A
P
S
P
V
P
E
E
Q
L
R
E
L
G
L
M
V
V
R
P
----
7
PsiBlast_PDB
78.51
48%
-92
- C7 -
4O2D
3
SYDND_MYCS2
A:
[23-603]
V
L
R
T
H
A
A
G
S
L
R
P
A
D
A
G
Q
T
V
T
L
A
G
W
V
A
R
R
R
D
H
G
G
V
I
F
I
D
L
R
D
A
S
G
V
S
Q
V
V
F
R
--
E
--
G
D
V
L
A
A
A
H
R
L
R
A
--
E
F
C
V
A
V
T
G
V
V
E
V
R
P
E
G
N
E
N
P
E
I
P
T
G
Q
I
E
V
N
A
T
E
L
T
V
L
G
E
S
-
A
P
L
P
F
Q
L
D
------
E
Q
------
A
--
G
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
E
G
P
G
N
A
L
R
L
R
S
K
V
N
A
A
A
R
S
V
L
A
E
-
H
D
F
V
E
I
E
T
P
T
L
T
R
S
T
P
E
G
A
R
D
F
L
V
P
A
R
L
Q
P
G
S
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
M
E
R
Y
Y
Q
I
A
R
C
Y
R
D
E
D
F
--
D
R
Q
-
P
E
F
T
Q
L
D
M
E
M
S
F
V
-
E
A
D
D
V
I
A
I
S
E
Q
V
L
K
A
V
W
A
T
I
G
Y
D
L
P
-------------
L
--
P
L
P
R
I
S
Y
E
E
A
M
R
R
F
G
S
D
K
P
D
L
R
F
G
I
E
L
V
E
C
T
E
Y
F
K
D
T
T
F
R
V
F
Q
A
P
------
Y
V
G
A
V
V
M
P
-
G
G
A
S
Q
P
R
R
T
L
D
G
W
Q
E
F
A
K
Q
R
G
H
K
G
L
A
Y
V
L
V
G
E
D
G
T
----
L
G
G
P
V
A
K
N
L
S
D
A
E
R
D
G
L
V
A
H
V
G
A
N
P
G
D
C
I
F
F
A
A
G
P
A
K
G
A
R
A
L
L
G
A
T
R
I
E
I
A
K
R
L
D
---
L
I
D
P
N
-
A
---
W
A
F
T
W
V
V
D
F
P
M
F
--
E
-
A
A
D
-
E
A
T
A
A
GDVAVGS
G
A
W
T
A
M
H
H
A
F
T
A
P
K
-
P
D
-
S
V
D
T
F
D
S
D
P
G
N
A
L
S
D
A
Y
D
I
V
C
N
G
N
E
I
G
G
G
S
I
R
I
H
R
R
D
I
Q
E
R
V
F
A
M
M
G
I
D
H
D
E
A
Q
E
K
F
G
F
L
L
D
A
F
S
Y
G
A
P
P
H
G
G
I
A
F
G
W
D
R
I
T
A
L
L
A
G
V
D
S
I
R
E
V
I
A
F
P
K
S
G
G
G
V
D
P
L
T
D
A
P
A
P
I
T
P
Q
Q
R
K
E
S
G
I
D
--------
6
PsiBlast_PDB
77.14
48%
-91
- C7 -
4RMF
2
SYDND_MYCS2
A:
[2-580]
-
L
R
T
H
A
A
G
S
L
R
P
A
D
A
G
Q
T
V
T
L
A
G
W
V
A
R
R
R
D
H
G
G
V
I
F
I
D
L
R
D
A
S
G
V
S
Q
V
V
F
R
--
E
--
G
D
V
L
A
A
A
H
R
L
R
A
--
E
F
C
V
A
V
T
G
V
V
E
V
R
P
E
G
N
E
N
P
E
I
P
T
G
Q
I
E
V
N
A
T
E
L
T
V
L
G
E
S
-
A
P
L
P
F
Q
L
D
------
E
Q
------
A
--
G
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
E
G
P
G
N
A
L
R
L
R
S
K
V
N
A
A
A
R
S
V
L
A
E
-
H
D
F
V
E
I
E
T
P
T
L
T
R
S
T
P
E
G
A
R
D
F
L
V
P
A
R
L
Q
P
G
S
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
M
E
R
Y
Y
Q
I
A
R
C
Y
R
D
E
D
F
R
A
D
R
Q
-
P
E
F
T
Q
L
D
M
E
M
S
F
V
-
E
A
D
D
V
I
A
I
S
E
Q
V
L
K
A
V
W
A
T
I
G
Y
D
L
P
-------------
L
--
P
L
P
R
I
S
Y
E
E
A
M
R
R
F
G
S
D
K
P
D
L
R
F
G
I
E
L
V
E
C
T
E
Y
F
K
D
T
T
F
R
V
F
Q
A
P
------
Y
V
G
A
V
V
M
P
-
G
G
A
S
Q
P
R
R
T
L
D
G
W
Q
E
F
A
K
Q
R
G
H
K
G
L
A
Y
V
L
V
G
E
D
G
T
----
L
G
G
P
V
A
K
N
L
S
D
A
E
R
D
G
L
V
A
H
V
G
A
N
P
G
D
C
I
F
F
A
A
G
P
A
K
G
A
R
A
L
L
G
A
T
R
I
E
I
A
K
R
L
D
---
L
I
D
P
N
-
A
---
W
A
F
T
W
V
V
D
F
P
M
F
--
E
-
A
A
D
-
E
ATAAGDVAVGS
G
A
W
T
A
M
H
H
A
F
T
A
P
K
-
P
D
-
S
V
D
T
F
D
S
D
P
G
N
A
L
S
D
A
Y
D
I
V
C
N
G
N
E
I
G
G
G
S
I
R
I
H
R
R
D
I
Q
E
R
V
F
A
M
M
G
I
D
H
D
E
A
Q
E
K
F
G
F
L
L
D
A
F
S
Y
G
A
P
P
H
G
G
I
A
F
G
W
D
R
I
T
A
L
L
A
G
V
D
S
I
R
E
V
I
A
F
P
K
S
G
G
G
V
D
P
L
T
D
A
P
A
P
I
T
P
Q
Q
R
K
E
S
G
----------
24
PsiBlast_CBE
74.24
48%
-84
- C7 -
4O2D
3
SYDND_MYCS2
B:
[23-603]
V
L
R
T
H
A
A
G
S
L
R
P
A
D
A
G
Q
T
V
T
L
A
G
W
V
A
R
R
R
D
H
G
G
V
I
F
I
D
L
R
D
A
S
G
V
S
Q
V
V
F
R
--
E
--
G
D
V
L
A
A
A
H
R
L
R
A
--
E
F
C
V
A
V
T
G
V
V
E
V
R
P
E
G
N
E
N
P
E
I
P
T
G
Q
I
E
V
N
A
T
E
L
T
V
L
G
E
S
-
A
P
L
P
F
Q
L
D
------
E
Q
------
A
--
G
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
E
G
P
G
N
A
L
R
L
R
S
K
V
N
A
A
A
R
S
V
L
A
E
-
H
D
F
V
E
I
E
T
P
T
L
T
R
S
T
P
E
G
A
R
D
F
L
V
P
A
R
L
Q
P
G
S
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
M
E
R
Y
Y
Q
I
A
R
C
Y
R
D
E
D
F
--
D
R
Q
-
P
E
F
T
Q
L
D
M
E
M
S
F
V
-
E
A
D
D
V
I
A
I
S
E
Q
V
L
K
A
V
W
A
T
I
G
Y
D
L
P
-------------
L
--
P
L
P
R
I
S
Y
E
E
A
M
R
R
F
G
S
D
K
P
D
L
R
F
G
I
E
L
V
E
C
T
E
Y
F
----------
P
------
Y
V
G
A
V
V
M
P
-------------
W
Q
E
F
A
K
Q
R
G
-----------------------------------------------
F
F
A
A
G
P
A
K
G
A
R
A
L
L
G
A
T
R
I
E
I
A
K
R
L
D
---
L
I
D
P
N
-
A
---
W
A
F
T
W
V
V
D
F
P
M
F
--
E
-
A
A
D
-
E
A
T
A
A
GDVAVGS
G
A
W
T
A
M
H
H
A
F
T
A
P
K
-
P
D
-
S
V
D
T
F
D
S
D
P
G
N
A
L
S
D
A
Y
D
I
V
C
N
G
N
E
I
G
G
G
S
I
R
I
H
R
R
D
I
Q
E
R
V
F
A
M
M
G
I
D
H
D
E
A
Q
E
K
F
G
F
L
L
D
A
F
S
Y
G
A
P
P
H
G
G
I
A
F
G
W
D
R
I
T
A
L
L
A
G
V
D
S
I
R
E
V
I
A
F
P
K
S
G
G
G
V
D
P
L
T
D
A
P
A
P
I
T
P
Q
Q
R
K
E
S
G
I
D
--------
11
PsiBlast_PDB
69.98
39%
-79
- C7 -
4AH6
-
SYDM_HUMAN
A:
[48-630]
V
V
R
T
N
T
C
G
E
L
R
S
S
H
L
G
Q
E
V
T
L
C
G
W
I
Q
Y
R
R
Q
N
---
T
F
L
V
L
R
D
F
D
G
L
V
Q
V
I
I
P
Q
D
E
--
S
A
A
S
V
K
K
I
L
C
E
A
PV
E
S
V
V
Q
V
S
G
T
V
I
S
R
P
A
G
Q
E
N
P
K
M
P
T
G
E
I
E
I
K
V
K
T
A
E
L
L
N
A
C
-
K
K
L
P
F
E
I
K
------
N
F
------
V
K
K
T
E
A
L
R
L
Q
Y
R
Y
L
D
L
R
S
F
Q
M
Q
Y
N
L
R
L
R
S
Q
M
V
M
K
M
R
E
Y
L
C
N
L
H
G
F
V
D
I
E
T
P
T
L
F
K
R
T
P
G
G
A
K
E
F
L
V
P
S
R
E
-
P
G
K
F
Y
S
L
P
Q
S
P
Q
Q
F
K
Q
L
L
M
V
G
G
L
D
R
Y
F
Q
V
A
R
C
Y
R
D
E
G
S
R
P
D
R
Q
-
P
E
F
T
Q
I
D
I
E
M
S
F
V
-
D
Q
T
G
I
Q
S
L
I
E
G
L
L
Q
Y
S
W
P
N
D
-
K
D
P
V
-------------
V
V
-
P
F
P
T
M
T
F
A
E
V
L
A
T
Y
G
T
D
K
P
D
T
R
F
G
M
K
I
I
D
I
S
D
V
F
R
N
T
E
I
G
F
L
Q
D
A
L
S
K
P
H
G
T
V
K
A
I
C
I
P
E
G
A
K
Y
L
K
R
K
D
I
E
S
I
R
N
F
A
A
D
H
F
N
Q
E
I
L
P
V
F
L
N
A
N
----
R
N
W
N
S
P
V
A
N
F
I
M
E
S
Q
R
L
E
L
I
R
L
M
E
T
Q
E
E
D
V
V
L
L
T
A
G
E
H
N
K
A
C
S
L
L
G
K
L
R
L
E
C
A
D
L
L
E
T
RG
V
V
L
-
R
-
D
PT
L
F
S
F
L
W
V
V
D
F
P
L
F
L
P
K
-
E
E
N
-
P
-----------
R
E
L
E
S
A
H
H
P
F
T
A
P
H
-
P
S
-
D
I
H
L
L
Y
T
E
P
K
K
A
R
S
Q
H
Y
D
L
V
L
N
G
N
E
I
G
G
G
S
I
R
I
H
N
A
E
L
Q
R
Y
I
L
A
T
L
L
K
E
D
V
K
M
---
L
S
H
L
L
Q
A
L
D
Y
G
A
P
P
H
G
G
I
A
L
G
L
D
R
L
I
C
L
V
T
G
S
P
S
I
R
D
V
I
A
F
P
K
S
F
R
G
H
D
L
M
S
N
T
P
D
S
V
P
P
E
E
L
K
P
Y
H
----------
46
HHSearch
59.46
32%
-79
* C7 *
3NEM
1
SYD_THEKO
A:
[1-435]
M
Y
R
T
H
Y
S
S
E
I
T
E
E
L
N
G
Q
K
V
K
V
A
G
W
V
W
E
V
K
D
L
G
G
I
K
F
L
W
I
R
D
R
D
G
I
V
Q
I
T
A
P
K
K
K
VD
P
E
L
F
K
L
I
P
K
L
R
S
--
E
D
V
V
A
V
E
G
V
V
N
F
T
P
K
-------
A
K
L
G
F
E
I
L
P
E
K
I
V
V
L
N
R
A
E
T
P
L
P
L
D
P
T
------
G
K
------
V
K
A
E
L
D
T
R
L
D
N
R
F
M
D
L
R
R
P
E
V
M
A
I
F
K
I
R
S
S
V
F
K
A
V
R
D
F
F
H
E
-
N
G
F
I
E
I
H
T
P
K
I
I
A
T
A
T
E
G
G
T
E
L
F
P
M
K
Y
--
F
E
E
D
A
F
L
A
Q
S
P
Q
L
Y
K
Q
I
M
M
A
S
G
L
D
R
V
Y
E
I
A
P
I
F
R
A
E
E
H
N
T
T
R
H
L
N
E
A
W
S
I
D
S
E
M
A
F
I
E
D
E
E
E
V
M
S
F
L
E
R
L
V
A
H
A
I
N
Y
V
-
R
E
H
N
A
K
E
L
D
I
L
N
F
E
L
E
E
P
K
L
P
F
P
R
V
S
Y
D
K
A
L
E
I
L
G
D
L
G
K
E
I
-------------------------------------------------------------------
P
W
G
E
--------------
D
I
D
T
--------------------------
E
G
E
R
L
L
G
K
Y
M
M
---
E
--------
N
-
E
-
N
---
A
P
L
Y
F
L
Y
Q
Y
P
S
--------------------------
E
A
K
P
F
Y
I
M
K
-
Y
D
-------
N
K
--
P
E
I
C
R
A
F
D
L
E
Y
R
G
V
E
I
S
S
G
G
Q
R
E
H
R
H
D
I
L
V
E
Q
I
K
E
K
G
L
N
P
----
E
S
F
E
F
Y
L
K
A
F
R
Y
G
M
P
P
H
G
G
F
G
L
G
A
E
R
L
I
K
Q
M
L
D
L
P
N
I
R
E
V
I
L
F
P
R
D
R
R
R
L
T
P
---------------------------
43
HHSearch
59.08
30%
-78
- C7 -
1WYD
3
SYDND_SULTO
A:
[1-427]
M
Y
R
S
H
F
I
A
D
V
T
P
E
Y
D
G
K
E
V
I
W
A
G
W
V
H
L
L
R
D
L
G
G
K
K
F
I
I
L
R
D
K
T
G
L
G
Q
V
V
V
D
K
N
S
---
S
A
F
G
I
S
Q
E
L
T
Q
--
E
S
V
I
Q
V
R
G
I
V
K
A
D
K
R
-------
A
P
R
G
I
E
L
H
A
E
E
I
T
L
L
S
K
A
K
A
P
L
P
L
D
V
S
------
G
K
------
V
K
A
D
I
D
T
R
L
R
E
R
V
L
D
L
R
R
Q
E
M
Q
A
V
I
K
I
Q
S
L
A
L
K
A
F
R
E
T
L
Y
K
-
E
G
F
I
E
I
F
T
P
K
I
I
A
S
A
T
E
G
G
A
Q
L
F
P
V
I
Y
--
F
G
K
E
A
F
L
A
Q
S
P
Q
L
Y
K
E
L
M
-
A
G
V
V
E
R
V
F
E
V
A
P
A
W
R
A
E
E
S
D
T
P
F
H
L
A
E
F
I
S
M
D
V
E
M
A
F
A
-
D
Y
N
D
V
M
Q
L
L
E
K
I
L
H
N
I
V
K
T
I
-
K
E
E
G
K
E
E
L
K
I
L
NYEPPE
V
K
I
P
I
K
R
L
K
Y
T
E
A
I
E
I
L
R
S
K
G
Y
N
I
K
-------------------------------------------------------------------
F
G
D
--------------
D
I
G
T
P
--------------------------
E
L
R
I
L
N
-------
E
E
L
----------
K
---
E
D
L
Y
F
I
V
D
W
P
S
--------------------------
D
A
R
P
F
Y
T
K
S
-
K
S
-------
E
-
P
--
E
L
S
E
S
F
D
L
I
Y
K
F
L
E
I
V
S
G
S
T
R
N
H
K
R
E
V
L
E
E
A
L
K
K
K
G
L
K
P
----
E
S
F
E
F
F
L
K
W
F
D
Y
G
M
P
P
H
A
G
F
G
M
G
L
A
R
L
M
V
M
L
T
G
I
Q
S
V
K
E
I
V
P
F
P
R
D
K
K
R
L
T
P
---------------------------