@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA1010: (2016-01-25 )
MIAGSMVALVTPFDAQGRLDWDSLAKLVDFHLQEGTNAIVAVGTTGESATLDVEEHIQVIRRVVDQVKGRIPVIAGTGANSTREAVALTEAAKSGGADACLLVTPYYNKPTQEGMYQHFRHIAEAVAIPQILYNVPGRTSCDMLPETVERLSKVPNIIGIKEATGDLQRAKEVIERVGKDFLVYSGDDATAVELMLLGGKGNISVTANVAPRAMSDLCAAAMRGDAAAARAINDRLMPLHKALFIESNPIPVKWALHEMGLIPEGIRLPLTWLSPRCHEPLRQAMRQTGVLA
Atome Classification :
(62 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150-.-.-.....160.......170.....-..180........190.......200.......210.......220.......230......---.240..---.....250.......260-...-....270........280.......290
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIAG
S
M
V
A
L
VTPFDAQGRL
D
W
D
S
L
A
K
L
V
D
F
H
L
QEGT
N
A
I
V
A
V
GTTGE
S
A
T
L
D
V
E
E
H
I
Q
V
I
R
R
V
V
D
Q
VKGRI
P
V
I
A
GTGANST
R
E
A
V
A
L
T
E
A
A
KSGGA
D
A
C
L
L
VTPYYNKP
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
YNVPGRTSCDM
L
P
E
T
V
E
R
L
S
-K-V-P
N
I
I
G
IKEATG
D
L
Q
R
A
K
E
V
I
E
R
V-GK
D
-
F
L
V
YSGDD
A
T
A
V
E
L
M
L
LGGKG
N
I
S
V
T
ANVA
P
R
A
M
S
D
L
C
A
A
A
MRG
D
A
A
A
A
R
A
IN
D
R
L
M
P
---
L
H
K
A
L
F
---IESNPI
P
V
K
W
A
L
H
EMGLI-PEG-
I
R
LP
L
-
T
WLSP
R
C
H
E
P
L
R
Q
A
M
R
QTGVLA
21
PsiBlast_CBE
98.51
100%
-117
- C7 -
3QZE
2
DAPA_PSEAE
D:
[24-313]
-
I
A
G
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
E
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
I
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
S
-
K
-
V
-
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
E
R
V
-
G
K
D
-
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
L
M
P
---
L
H
K
A
L
F
---
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
P
E
G
-
I
R
L
P
L
-
T
W
L
S
P
R
C
H
E
P
L
R
Q
A
M
R
Q
T
G
V
L
-
23
PsiBlast_CBE
98.44
100%
-115
- C7 -
3QZE
2
DAPA_PSEAE
B:
[24-313]
-
I
A
G
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
E
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
I
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
S
-
K
-
V
-
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
E
R
V
-
G
K
D
-
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
L
M
P
---
L
H
K
A
L
F
---
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
P
E
G
-
I
R
L
P
L
-
T
W
L
S
P
R
C
H
E
P
L
R
Q
A
M
R
Q
T
G
V
L
-
22
PsiBlast_CBE
98.34
100%
-116
- C7 -
3QZE
2
DAPA_PSEAE
C:
[24-313]
-
I
A
G
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
E
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
I
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
S
-
K
-
V
-
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
E
R
V
-
G
K
D
-
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
L
M
P
---
L
H
K
A
L
F
---
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
P
E
G
-
I
R
L
P
L
-
T
W
L
S
P
R
C
H
E
P
L
R
Q
A
M
R
Q
T
G
V
L
-
1
PsiBlast_PDB
98.22
100%
-117
- C7 -
3QZE
2
DAPA_PSEAE
A:
[23-313]
M
I
A
G
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
E
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
I
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
S
-
K
-
V
-
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
E
R
V
-
G
K
D
-
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
L
M
P
---
L
H
K
A
L
F
---
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
P
E
G
-
I
R
L
P
L
-
T
W
L
S
P
R
C
H
E
P
L
R
Q
A
M
R
Q
T
G
V
L
-
103
HHSearch
97.73
99%
-118
- C7 -
3QZE
2
DAPA_PSEAE
A:
[23-313]
M
I
A
G
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
E
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
I
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
S
-
K
-
V
-
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
E
R
V
-
G
K
D
-
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
L
M
P
---
L
H
K
A
L
F
---
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
--
P
E
G
I
R
L
P
L
-
T
W
L
S
P
R
C
H
E
P
L
R
Q
A
M
R
Q
T
G
V
L
-
4
PsiBlast_PDB
97.72
98%
-121
- C7 -
3PUO
4
DAPA_PSEAE
A:
[1-292]
M
I
A
G
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
D
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
V
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
S
-
K
-
V
-
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
E
R
V
-
G
K
D
-
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
L
M
P
---
L
H
K
A
L
F
---
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
P
E
G
-
I
R
L
P
L
-
T
W
L
S
P
H
C
H
D
P
L
R
Q
A
M
R
Q
T
G
V
L
A
3
PsiBlast_PDB
97.64
98%
-116
- C7 -
3PS7
4
DAPA_PSEAE
A:
[1-292]
M
I
A
G
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
D
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
V
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
S
-
K
-
V
-
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
E
R
V
-
G
K
D
-
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
L
M
P
---
L
H
K
A
L
F
---
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
P
E
G
-
I
R
L
P
L
-
T
W
L
S
P
H
C
H
D
P
L
R
Q
A
M
R
Q
T
G
V
L
A
26
PsiBlast_CBE
97.54
98%
-118
- C7 -
3PS7
4
DAPA_PSEAE
B:
[1-292]
M
I
A
G
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
D
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
V
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
S
-
K
-
V
-
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
E
R
V
-
G
K
D
-
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
L
M
P
---
L
H
K
A
L
F
---
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
P
E
G
-
I
R
L
P
L
-
T
W
L
S
P
H
C
H
D
P
L
R
Q
A
M
R
Q
T
G
V
L
A
5
PsiBlast_PDB
97.43
98%
-119
- C7 -
3S8H
1
DAPA_PSEAE
A:
[1-292]
M
I
A
G
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
D
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
V
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
S
-
K
-
V
-
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
E
R
V
-
G
K
D
-
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
L
M
P
---
L
H
K
A
L
F
---
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
P
E
G
-
I
R
L
P
L
-
T
W
L
S
P
H
C
H
D
P
L
R
Q
A
M
R
Q
T
G
V
L
A
2
PsiBlast_PDB
97.34
98%
-116
- C7 -
3NOE
5
DAPA_PSEAE
A:
[1-292]
M
I
A
G
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
D
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
V
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
S
-
K
-
V
-
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
E
R
V
-
G
K
D
-
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
L
M
P
---
L
H
K
A
L
F
---
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
P
E
G
-
I
R
L
P
L
-
T
W
L
S
P
H
C
H
D
P
L
R
Q
A
M
R
Q
T
G
V
L
A
24
PsiBlast_CBE
97.30
98%
-115
- C7 -
3S8H
1
DAPA_PSEAE
B:
[1-292]
M
I
A
G
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
D
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
V
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
S
-
K
-
V
-
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
E
R
V
-
G
K
D
-
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
L
M
P
---
L
H
K
A
L
F
---
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
P
E
G
-
I
R
L
P
L
-
T
W
L
S
P
H
C
H
D
P
L
R
Q
A
M
R
Q
T
G
V
L
A
25
PsiBlast_CBE
97.26
98%
-116
- C7 -
3PUO
3
DAPA_PSEAE
B:
[1-292]
M
I
A
G
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
D
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
V
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
S
-
K
-
V
-
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
E
R
V
-
G
K
D
-
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
L
M
P
---
L
H
K
A
L
F
---
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
P
E
G
-
I
R
L
P
L
-
T
W
L
S
P
H
C
H
D
P
L
R
Q
A
M
R
Q
T
G
V
L
A
27
PsiBlast_CBE
96.94
98%
-118
- C7 -
3NOE
4
DAPA_PSEAE
B:
[1-292]
M
I
A
G
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
D
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
V
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
S
-
K
-
V
-
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
E
R
V
-
G
K
D
-
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
L
M
P
---
L
H
K
A
L
F
---
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
P
E
G
-
I
R
L
P
L
-
T
W
L
S
P
H
C
H
D
P
L
R
Q
A
M
R
Q
T
G
V
L
A
13
PsiBlast_PDB
85.48
61%
-110
- C7 -
3U8G
1
?
A:
[2-291]
-
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
-
I
-
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
L
I
D
A
L
-
N
G
K
-
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
I
A
N
---
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
31
PsiBlast_CBE
85.41
61%
-112
- C7 -
3TDF
1
?
B:
[2-291]
-
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
-
I
-
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
L
I
D
A
L
-
N
G
K
-
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
I
A
N
---
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
30
PsiBlast_CBE
85.22
61%
-110
- C7 -
3U8G
1
?
B:
[2-291]
-
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
-
I
-
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
L
I
D
A
L
-
N
G
K
-
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
I
A
N
---
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
33
PsiBlast_CBE
84.84
61%
-110
- C7 -
3TAK
5
?
B:
[2-291]
-
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
-
I
-
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
L
I
D
A
L
-
N
G
K
-
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
I
A
N
---
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
34
PsiBlast_CBE
84.66
61%
-111
- C7 -
3RK8
8
?
B:
[2-291]
-
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
-
I
-
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
L
I
D
A
L
-
N
G
K
-
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
I
A
N
---
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
15
PsiBlast_PDB
84.62
61%
-109
- C7 -
4DXV
3
?
A:
[2-291]
-
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
-
I
-
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
L
I
D
A
L
-
N
G
K
-
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
I
A
N
---
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
9
PsiBlast_PDB
84.62
61%
-112
- C7 -
3RK8
8
?
A:
[2-291]
-
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
-
I
-
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
L
I
D
A
L
-
N
G
K
-
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
I
A
N
---
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
11
PsiBlast_PDB
84.36
61%
-108
- C7 -
3TCE
2
?
A:
[2-291]
-
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
-
I
-
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
L
I
D
A
L
-
N
G
K
-
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
I
A
N
---
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
35
PsiBlast_CBE
84.23
61%
-111
- C7 -
3PUL
8
?
B:
[2-291]
-
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
-
I
-
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
L
I
D
A
L
-
N
G
K
-
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
I
A
N
---
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
106
HHSearch
84.21
61%
-110
- C7 -
3TAK
3
?
A:
[1-290]
T
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
-
I
-
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
L
I
D
A
L
-
N
G
K
-
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
I
A
N
---
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
--
D
T
G
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
37
PsiBlast_CBE
83.68
61%
-109
- C7 -
3PUD
6
?
B:
[2-291]
-
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
-
I
-
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
L
I
D
A
L
-
N
G
K
-
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
I
A
N
---
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
8
PsiBlast_PDB
83.58
61%
-110
- C7 -
3PUL
6
?
A:
[2-291]
-
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
-
I
-
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
L
I
D
A
L
-
N
G
K
-
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
I
A
N
---
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
36
PsiBlast_CBE
83.35
61%
-107
- C7 -
3PUE
6
?
B:
[2-291]
-
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
-
I
-
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
L
I
D
A
L
-
N
G
K
-
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
I
A
N
---
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
32
PsiBlast_CBE
83.25
61%
-107
- C7 -
3TCE
2
?
B:
[2-291]
-
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
-
I
-
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
L
I
D
A
L
-
N
G
K
-
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
I
A
N
---
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
7
PsiBlast_PDB
83.19
61%
-110
- C7 -
3PUE
4
?
A:
[2-291]
-
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
-
I
-
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
L
I
D
A
L
-
N
G
K
-
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
I
A
N
---
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
108
HHSearch
82.18
52%
-106
- C7 -
3FLU
13
DAPA_NEIMB
A:
[7-296]
M
L
Q
G
S
L
V
A
L
I
T
P
M
N
Q
D
G
S
I
H
Y
E
Q
L
R
D
L
I
D
W
H
I
E
N
G
T
D
G
I
V
A
V
G
T
T
G
E
S
A
T
L
S
V
E
E
H
T
A
V
I
E
A
V
V
K
H
V
A
K
R
V
P
V
I
A
G
T
G
A
N
N
T
V
E
A
I
A
L
S
Q
A
A
E
K
A
G
A
D
Y
T
L
S
V
V
P
Y
Y
N
K
P
S
Q
E
G
I
Y
Q
H
F
K
T
I
A
E
A
T
S
I
P
M
I
I
Y
N
V
P
G
R
T
V
V
S
M
T
N
D
T
I
L
R
L
A
-
E
-
I
-
P
N
I
V
G
V
K
E
A
S
G
N
I
G
S
N
I
E
L
I
N
R
A
-
P
E
G
-
F
V
V
L
S
G
D
D
H
T
A
L
P
F
M
L
C
G
G
H
G
V
I
T
V
A
A
N
A
A
P
K
L
F
A
D
M
C
R
A
A
L
Q
G
D
I
A
L
A
R
E
L
N
D
R
L
I
P
---
I
Y
D
T
M
F
---
C
E
P
S
P
A
A
P
K
W
A
V
S
A
L
G
R
C
--
E
P
H
V
R
L
P
L
-
V
P
L
T
E
N
G
Q
A
K
V
R
A
A
L
K
A
S
G
Q
L
-
59
PsiBlast_CBE
81.81
51%
-105
- C7 -
3FLU
12
DAPA_NEIMB
B:
[7-297]
M
L
Q
G
S
L
V
A
L
I
T
P
M
N
Q
D
G
S
I
H
Y
E
Q
L
R
D
L
I
D
W
H
I
E
N
G
T
D
G
I
V
A
V
G
T
T
G
E
S
A
T
L
S
V
E
E
H
T
A
V
I
E
A
V
V
K
H
V
A
K
R
V
P
V
I
A
G
T
G
A
N
N
T
V
E
A
I
A
L
S
Q
A
A
E
K
A
G
A
D
Y
T
L
S
V
V
P
Y
Y
N
K
P
S
Q
E
G
I
Y
Q
H
F
K
T
I
A
E
A
T
S
I
P
M
I
I
Y
N
V
P
G
R
T
V
V
S
M
T
N
D
T
I
L
R
L
A
-
E
-
I
-
P
N
I
V
G
V
K
E
A
S
G
N
I
G
S
N
I
E
L
I
N
R
A
-
P
E
G
-
F
V
V
L
S
G
D
D
H
T
A
L
P
F
M
L
C
G
G
H
G
V
I
T
V
A
A
N
A
A
P
K
L
F
A
D
M
C
R
A
A
L
Q
G
D
I
A
L
A
R
E
L
N
D
R
L
I
P
---
I
Y
D
T
M
F
---
C
E
P
S
P
A
A
P
K
W
A
V
S
A
L
G
R
C
-
E
P
H
-
V
R
L
P
L
-
V
P
L
T
E
N
G
Q
A
K
V
R
A
A
L
K
A
S
G
Q
L
-
60
PsiBlast_CBE
81.71
51%
-105
- C7 -
3FLU
13
DAPA_NEIMB
A:
[7-297]
M
L
Q
G
S
L
V
A
L
I
T
P
M
N
Q
D
G
S
I
H
Y
E
Q
L
R
D
L
I
D
W
H
I
E
N
G
T
D
G
I
V
A
V
G
T
T
G
E
S
A
T
L
S
V
E
E
H
T
A
V
I
E
A
V
V
K
H
V
A
K
R
V
P
V
I
A
G
T
G
A
N
N
T
V
E
A
I
A
L
S
Q
A
A
E
K
A
G
A
D
Y
T
L
S
V
V
P
Y
Y
N
K
P
S
Q
E
G
I
Y
Q
H
F
K
T
I
A
E
A
T
S
I
P
M
I
I
Y
N
V
P
G
R
T
V
V
S
M
T
N
D
T
I
L
R
L
A
-
E
-
I
-
P
N
I
V
G
V
K
E
A
S
G
N
I
G
S
N
I
E
L
I
N
R
A
-
P
E
G
-
F
V
V
L
S
G
D
D
H
T
A
L
P
F
M
L
C
G
G
H
G
V
I
T
V
A
A
N
A
A
P
K
L
F
A
D
M
C
R
A
A
L
Q
G
D
I
A
L
A
R
E
L
N
D
R
L
I
P
---
I
Y
D
T
M
F
---
C
E
P
S
P
A
A
P
K
W
A
V
S
A
L
G
R
C
-
E
P
H
-
V
R
L
P
L
-
V
P
L
T
E
N
G
Q
A
K
V
R
A
A
L
K
A
S
G
Q
L
-
18
PsiBlast_PDB
81.57
57%
-108
- C7 -
1YXD
3
DAPA_ECOLI
A:
[1-292]
M
F
T
G
S
I
V
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
A
-
K
-
V
-
K
N
I
I
G
I
K
E
A
T
G
N
L
T
R
V
N
Q
I
K
E
L
V
-
S
D
D
-
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
---
L
H
N
K
L
F
---
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
-
L
R
L
P
M
-
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
A
G
L
L
-
46
PsiBlast_CBE
81.15
56%
-111
- C7 -
3I7Q
7
DAPA_ECOLI
B:
[1-292]
M
F
T
G
S
I
V
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
A
-
K
-
V
-
K
N
I
I
G
I
R
E
A
T
G
N
L
T
R
V
N
Q
I
K
E
L
V
-
S
D
D
-
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
---
L
H
N
K
L
F
---
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
-
L
R
L
P
M
-
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
A
G
L
L
-
39
PsiBlast_CBE
81.12
57%
-107
- C7 -
1YXD
4
DAPA_ECOLI
B:
[1-292]
M
F
T
G
S
I
V
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
A
-
K
-
V
-
K
N
I
I
G
I
K
E
A
T
G
N
L
T
R
V
N
Q
I
K
E
L
V
-
S
D
D
-
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
---
L
H
N
K
L
F
---
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
-
L
R
L
P
M
-
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
A
G
L
L
-
44
PsiBlast_CBE
80.78
56%
-109
- C7 -
3I7R
8
DAPA_ECOLI
B:
[1-292]
M
F
T
G
S
I
V
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
A
-
K
-
V
-
K
N
I
I
G
I
R
E
A
T
G
N
L
T
R
V
N
Q
I
K
E
L
V
-
S
D
D
-
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
---
L
H
N
K
L
F
---
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
-
L
R
L
P
M
-
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
A
G
L
L
-
19
PsiBlast_PDB
80.69
57%
-107
- C7 -
2ATS
3
DAPA_ECOLI
A:
[1-292]
M
F
T
G
S
I
V
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
A
-
K
-
V
-
K
N
I
I
G
I
K
E
A
T
G
N
L
T
R
V
N
Q
I
K
E
L
V
-
S
D
D
-
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
---
L
H
N
K
L
F
---
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
-
L
R
L
P
M
-
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
A
G
L
L
-
38
PsiBlast_CBE
80.68
57%
-108
- C7 -
2ATS
3
DAPA_ECOLI
B:
[1-292]
M
F
T
G
S
I
V
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
A
-
K
-
V
-
K
N
I
I
G
I
K
E
A
T
G
N
L
T
R
V
N
Q
I
K
E
L
V
-
S
D
D
-
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
---
L
H
N
K
L
F
---
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
-
L
R
L
P
M
-
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
A
G
L
L
-
45
PsiBlast_CBE
80.66
56%
-108
- C7 -
3I7R
10
DAPA_ECOLI
A:
[1-292]
M
F
T
G
S
I
V
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
A
-
K
-
V
-
K
N
I
I
G
I
R
E
A
T
G
N
L
T
R
V
N
Q
I
K
E
L
V
-
S
D
D
-
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
---
L
H
N
K
L
F
---
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
-
L
R
L
P
M
-
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
A
G
L
L
-
42
PsiBlast_CBE
80.56
56%
-108
- C7 -
3I7S
13
DAPA_ECOLI
B:
[1-292]
M
F
T
G
S
I
V
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
A
-
K
-
V
-
K
N
I
I
G
I
R
E
A
T
G
N
L
T
R
V
N
Q
I
K
E
L
V
-
S
D
D
-
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
---
L
H
N
K
L
F
---
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
-
L
R
L
P
M
-
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
A
G
L
L
-
54
PsiBlast_CBE
80.54
56%
-110
- C7 -
4ICN
6
?
A:
[7-294]
M
I
N
G
S
I
V
A
L
I
T
P
L
N
S
D
G
T
V
D
Y
T
S
L
E
K
L
V
E
Y
H
I
T
E
G
T
D
A
I
V
A
V
G
T
T
G
E
S
A
T
L
P
I
S
E
H
I
A
V
V
G
Q
T
V
K
F
A
S
G
R
I
P
V
I
G
G
N
G
A
N
A
T
A
E
A
I
E
L
T
K
A
Q
N
K
L
G
V
A
A
M
L
G
V
T
P
Y
Y
N
K
P
S
P
K
G
L
I
A
H
Y
T
A
V
A
A
S
T
D
I
P
Q
I
L
Y
N
V
P
G
R
T
A
V
D
M
L
P
E
T
I
A
Q
L
V
-
E
-
V
-
P
N
I
I
G
V
K
D
A
T
G
D
V
A
R
V
K
Q
L
R
D
L
C
-
G
N
D
-
F
L
L
Y
S
G
D
D
A
T
A
R
E
F
L
T
L
G
G
D
G
V
I
S
V
A
N
N
I
V
P
K
L
F
K
L
M
C
D
A
A
L
A
G
D
T
Q
A
A
M
A
A
E
D
Q
I
K
G
---
L
F
S
A
L
F
---
C
E
A
N
P
I
P
V
K
W
A
A
H
K
M
G
L
I
-
S
Q
G
D
I
R
L
P
L
-
T
E
L
S
T
E
F
H
G
L
L
L
D
A
M
K
N
A
R
I
E
V
53
PsiBlast_CBE
80.47
56%
-110
- C7 -
4ICN
4
?
B:
[7-294]
M
I
N
G
S
I
V
A
L
I
T
P
L
N
S
D
G
T
V
D
Y
T
S
L
E
K
L
V
E
Y
H
I
T
E
G
T
D
A
I
V
A
V
G
T
T
G
E
S
A
T
L
P
I
S
E
H
I
A
V
V
G
Q
T
V
K
F
A
S
G
R
I
P
V
I
G
G
N
G
A
N
A
T
A
E
A
I
E
L
T
K
A
Q
N
K
L
G
V
A
A
M
L
G
V
T
P
Y
Y
N
K
P
S
P
K
G
L
I
A
H
Y
T
A
V
A
A
S
T
D
I
P
Q
I
L
Y
N
V
P
G
R
T
A
V
D
M
L
P
E
T
I
A
Q
L
V
-
E
-
V
-
P
N
I
I
G
V
K
D
A
T
G
D
V
A
R
V
K
Q
L
R
D
L
C
-
G
N
D
-
F
L
L
Y
S
G
D
D
A
T
A
R
E
F
L
T
L
G
G
D
G
V
I
S
V
A
N
N
I
V
P
K
L
F
K
L
M
C
D
A
A
L
A
G
D
T
Q
A
A
M
A
A
E
D
Q
I
K
G
---
L
F
S
A
L
F
---
C
E
A
N
P
I
P
V
K
W
A
A
H
K
M
G
L
I
-
S
Q
G
D
I
R
L
P
L
-
T
E
L
S
T
E
F
H
G
L
L
L
D
A
M
K
N
A
R
I
E
V
56
PsiBlast_CBE
80.33
56%
-110
- C7 -
4PFM
5
?
A:
[2-289]
M
I
N
G
S
I
V
A
L
I
T
P
L
N
S
D
G
T
V
D
Y
T
S
L
E
K
L
V
E
Y
H
I
T
E
G
T
D
A
I
V
A
V
G
T
T
G
E
S
A
T
L
P
I
S
E
H
I
A
V
V
G
Q
T
V
K
F
A
S
G
R
I
P
V
I
G
G
N
G
A
N
A
T
A
E
A
I
E
L
T
K
A
Q
N
K
L
G
V
A
A
M
L
G
V
T
P
Y
Y
N
K
P
S
P
K
G
L
I
A
H
Y
T
A
V
A
A
S
T
D
I
P
Q
I
L
Y
N
V
P
G
R
T
A
V
D
M
L
P
E
T
I
A
Q
L
V
-
E
-
V
-
P
N
I
I
G
V
-
D
A
T
G
D
V
A
R
V
K
Q
L
R
D
L
C
-
G
N
D
-
F
L
L
Y
S
G
D
D
A
T
A
R
E
F
L
T
L
G
G
D
G
V
I
S
V
A
N
N
I
V
P
K
L
F
K
L
M
C
D
A
A
L
A
G
D
T
Q
A
A
M
A
A
E
D
Q
I
K
G
---
L
F
S
A
L
F
---
C
E
A
N
P
I
P
V
K
W
A
A
H
K
M
G
L
I
-
S
Q
G
D
I
R
L
P
L
-
T
E
L
S
T
E
F
H
G
L
L
L
D
A
M
K
N
A
R
I
E
V
55
PsiBlast_CBE
80.28
56%
-110
- C7 -
4PFM
6
?
B:
[2-289]
M
I
N
G
S
I
V
A
L
I
T
P
L
N
S
D
G
T
V
D
Y
T
S
L
E
K
L
V
E
Y
H
I
T
E
G
T
D
A
I
V
A
V
G
T
T
G
E
S
A
T
L
P
I
S
E
H
I
A
V
V
G
Q
T
V
K
F
A
S
G
R
I
P
V
I
G
G
N
G
A
N
A
T
A
E
A
I
E
L
T
K
A
Q
N
K
L
G
V
A
A
M
L
G
V
T
P
Y
Y
N
K
P
S
P
K
G
L
I
A
H
Y
T
A
V
A
A
S
T
D
I
P
Q
I
L
Y
N
V
P
G
R
T
A
V
D
M
L
P
E
T
I
A
Q
L
V
-
E
-
V
-
P
N
I
I
G
V
-
D
A
T
G
D
V
A
R
V
K
Q
L
R
D
L
C
-
G
N
D
-
F
L
L
Y
S
G
D
D
A
T
A
R
E
F
L
T
L
G
G
D
G
V
I
S
V
A
N
N
I
V
P
K
L
F
K
L
M
C
D
A
A
L
A
G
D
T
Q
A
A
M
A
A
E
D
Q
I
K
G
---
L
F
S
A
L
F
---
C
E
A
N
P
I
P
V
K
W
A
A
H
K
M
G
L
I
-
S
Q
G
D
I
R
L
P
L
-
T
E
L
S
T
E
F
H
G
L
L
L
D
A
M
K
N
A
R
I
E
V
20
PsiBlast_PDB
79.99
56%
-108
- C7 -
3I7Q
7
DAPA_ECOLI
A:
[1-292]
M
F
T
G
S
I
V
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
A
-
K
-
V
-
K
N
I
I
G
I
R
E
A
T
G
N
L
T
R
V
N
Q
I
K
E
L
V
-
S
D
D
-
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
---
L
H
N
K
L
F
---
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
-
L
R
L
P
M
-
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
A
G
L
L
-
43
PsiBlast_CBE
79.85
56%
-106
- C7 -
3I7S
10
DAPA_ECOLI
A:
[1-292]
M
F
T
G
S
I
V
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
A
-
K
-
V
-
K
N
I
I
G
I
R
E
A
T
G
N
L
T
R
V
N
Q
I
K
E
L
V
-
S
D
D
-
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
---
L
H
N
K
L
F
---
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
-
L
R
L
P
M
-
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
A
G
L
L
-
52
PsiBlast_CBE
79.63
55%
-110
- C7 -
3G0S
4
DAPA_SALTY
A:
[25-316]
M
F
T
G
S
I
V
A
L
V
T
P
M
D
E
K
G
N
V
S
R
S
C
L
K
K
L
I
D
Y
H
V
A
N
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
S
H
D
E
H
G
D
V
V
M
M
T
L
E
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
T
Q
E
G
L
F
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
M
L
P
E
T
V
G
R
L
A
-
E
-
I
-
K
N
I
I
A
I
K
E
A
T
G
N
L
T
R
V
H
Q
I
K
E
L
V
-
S
D
D
-
F
I
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
E
M
A
D
M
C
K
L
A
A
E
G
Q
F
A
E
A
R
A
I
N
Q
R
L
M
P
---
L
H
N
K
L
F
---
V
E
P
N
P
I
P
V
K
W
A
C
K
A
L
G
L
V
A
T
D
T
-
L
R
L
P
M
-
T
P
I
T
D
H
G
R
D
I
V
K
A
A
L
Q
H
A
G
L
L
-
51
PsiBlast_CBE
79.42
55%
-111
- C7 -
3G0S
4
DAPA_SALTY
B:
[25-316]
M
F
T
G
S
I
V
A
L
V
T
P
M
D
E
K
G
N
V
S
R
S
C
L
K
K
L
I
D
Y
H
V
A
N
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
S
H
D
E
H
G
D
V
V
M
M
T
L
E
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
T
Q
E
G
L
F
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
M
L
P
E
T
V
G
R
L
A
-
E
-
I
-
K
N
I
I
A
I
K
E
A
T
G
N
L
T
R
V
H
Q
I
K
E
L
V
-
S
D
D
-
F
I
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
E
M
A
D
M
C
K
L
A
A
E
G
Q
F
A
E
A
R
A
I
N
Q
R
L
M
P
---
L
H
N
K
L
F
---
V
E
P
N
P
I
P
V
K
W
A
C
K
A
L
G
L
V
A
T
D
T
-
L
R
L
P
M
-
T
P
I
T
D
H
G
R
D
I
V
K
A
A
L
Q
H
A
G
L
L
-
113
HHSearch
78.95
46%
-105
- C7 -
3SI9
3
DAPA_BARHE
A:
[22-313]
M
L
K
G
A
V
T
A
L
I
T
P
F
D
D
N
G
A
I
D
E
K
A
F
C
N
F
V
E
W
Q
I
T
Q
G
I
N
G
V
S
P
V
G
T
T
G
E
S
P
T
L
T
H
E
E
H
K
R
I
I
E
L
C
V
E
Q
V
A
K
R
V
P
V
V
A
G
A
G
S
N
S
T
S
E
A
V
E
L
A
K
H
A
E
K
A
G
A
D
A
V
L
V
V
T
P
Y
Y
N
R
P
N
Q
R
G
L
Y
T
H
F
S
S
I
A
K
A
I
S
I
P
I
I
I
Y
N
I
P
S
R
S
V
I
D
M
A
V
E
T
M
R
D
L
C
R
D
-
F
-
K
N
I
I
G
V
K
D
A
T
G
K
I
E
R
A
S
E
Q
R
E
K
C
-
G
K
D
-
F
V
Q
L
S
G
D
D
C
T
A
L
G
F
N
A
H
G
G
V
G
C
I
S
V
S
S
N
V
A
P
K
L
C
A
Q
L
H
A
A
C
L
C
S
D
Y
K
T
A
L
K
L
N
D
L
L
M
P
---
L
N
R
A
V
F
---
I
E
P
S
P
A
G
I
K
Y
A
A
A
K
L
G
L
C
--
G
T
I
V
R
S
P
I
-
V
P
L
S
D
T
T
K
K
I
I
D
E
A
L
Y
H
A
G
L
L
K
84
PsiBlast_CBE
78.55
45%
-107
- C7 -
3SI9
2
DAPA_BARHE
B:
[22-313]
M
L
K
G
A
V
T
A
L
I
T
P
F
D
D
N
G
A
I
D
E
K
A
F
C
N
F
V
E
W
Q
I
T
Q
G
I
N
G
V
S
P
V
G
T
T
G
E
S
P
T
L
T
H
E
E
H
K
R
I
I
E
L
C
V
E
Q
V
A
K
R
V
P
V
V
A
G
A
G
S
N
S
T
S
E
A
V
E
L
A
K
H
A
E
K
A
G
A
D
A
V
L
V
V
T
P
Y
Y
N
R
P
N
Q
R
G
L
Y
T
H
F
S
S
I
A
K
A
I
S
I
P
I
I
I
Y
N
I
P
S
R
S
V
I
D
M
A
V
E
T
M
R
D
L
C
-
R
D
F
-
K
N
I
I
G
V
K
D
A
T
G
K
I
E
R
A
S
E
Q
R
E
K
C
-
G
K
D
-
F
V
Q
L
S
G
D
D
C
T
A
L
G
F
N
A
H
G
G
V
G
C
I
S
V
S
S
N
V
A
P
K
L
C
A
Q
L
H
A
A
C
L
C
S
D
Y
K
T
A
L
K
L
N
D
L
L
M
P
---
L
N
R
A
V
F
---
I
E
P
S
P
A
G
I
K
Y
A
A
A
K
L
G
L
C
-
G
T
I
-
V
R
S
P
I
-
V
P
L
S
D
T
T
K
K
I
I
D
E
A
L
Y
H
A
G
L
L
-
85
PsiBlast_CBE
78.51
45%
-105
- C7 -
3SI9
3
DAPA_BARHE
A:
[22-313]
M
L
K
G
A
V
T
A
L
I
T
P
F
D
D
N
G
A
I
D
E
K
A
F
C
N
F
V
E
W
Q
I
T
Q
G
I
N
G
V
S
P
V
G
T
T
G
E
S
P
T
L
T
H
E
E
H
K
R
I
I
E
L
C
V
E
Q
V
A
K
R
V
P
V
V
A
G
A
G
S
N
S
T
S
E
A
V
E
L
A
K
H
A
E
K
A
G
A
D
A
V
L
V
V
T
P
Y
Y
N
R
P
N
Q
R
G
L
Y
T
H
F
S
S
I
A
K
A
I
S
I
P
I
I
I
Y
N
I
P
S
R
S
V
I
D
M
A
V
E
T
M
R
D
L
C
-
R
D
F
-
K
N
I
I
G
V
K
D
A
T
G
K
I
E
R
A
S
E
Q
R
E
K
C
-
G
K
D
-
F
V
Q
L
S
G
D
D
C
T
A
L
G
F
N
A
H
G
G
V
G
C
I
S
V
S
S
N
V
A
P
K
L
C
A
Q
L
H
A
A
C
L
C
S
D
Y
K
T
A
L
K
L
N
D
L
L
M
P
---
L
N
R
A
V
F
---
I
E
P
S
P
A
G
I
K
Y
A
A
A
K
L
G
L
C
-
G
T
I
-
V
R
S
P
I
-
V
P
L
S
D
T
T
K
K
I
I
D
E
A
L
Y
H
A
G
L
L
K
83
PsiBlast_CBE
78.24
45%
-104
- C7 -
3SI9
3
DAPA_BARHE
C:
[22-313]
M
L
K
G
A
V
T
A
L
I
T
P
F
D
D
N
G
A
I
D
E
K
A
F
C
N
F
V
E
W
Q
I
T
Q
G
I
N
G
V
S
P
V
G
T
T
G
E
S
P
T
L
T
H
E
E
H
K
R
I
I
E
L
C
V
E
Q
V
A
K
R
V
P
V
V
A
G
A
G
S
N
S
T
S
E
A
V
E
L
A
K
H
A
E
K
A
G
A
D
A
V
L
V
V
T
P
Y
Y
N
R
P
N
Q
R
G
L
Y
T
H
F
S
S
I
A
K
A
I
S
I
P
I
I
I
Y
N
I
P
S
R
S
V
I
D
M
A
V
E
T
M
R
D
L
C
-
R
D
F
-
K
N
I
I
G
V
K
D
A
T
G
K
I
E
R
A
S
E
Q
R
E
K
C
-
G
K
D
-
F
V
Q
L
S
G
D
D
C
T
A
L
G
F
N
A
H
G
G
V
G
C
I
S
V
S
S
N
V
A
P
K
L
C
A
Q
L
H
A
A
C
L
C
S
D
Y
K
T
A
L
K
L
N
D
L
L
M
P
---
L
N
R
A
V
F
---
I
E
P
S
P
A
G
I
K
Y
A
A
A
K
L
G
L
C
-
G
T
I
-
V
R
S
P
I
-
V
P
L
S
D
T
T
K
K
I
I
D
E
A
L
Y
H
A
G
L
L
-
73
PsiBlast_CBE
78.06
45%
-106
- C7 -
4I7U
3
DAPA_AGRFC
D:
[15-307]
M
F
K
G
S
I
P
A
L
I
T
P
F
T
D
N
G
A
V
D
E
Q
A
F
A
A
H
V
E
W
Q
I
A
E
G
S
N
G
L
V
P
V
G
T
T
G
E
S
P
T
L
S
H
D
E
H
K
R
V
V
E
L
C
I
E
V
A
A
K
R
V
P
V
I
A
G
A
G
S
N
N
T
D
E
A
I
E
L
A
L
H
A
Q
D
A
G
A
D
A
L
L
V
V
T
P
Y
Y
N
K
P
T
Q
K
G
L
F
A
H
F
S
A
V
A
E
A
V
K
L
P
I
V
I
Y
N
I
P
P
R
S
V
V
D
M
S
P
E
T
M
G
A
L
V
-
K
-
A
H
K
N
I
V
G
V
K
D
A
T
G
K
L
D
R
V
S
E
Q
R
I
S
C
-
G
K
D
-
F
I
Q
L
S
G
E
D
S
T
A
L
G
F
N
A
H
G
G
V
G
C
I
S
V
S
A
N
V
A
P
R
L
C
S
E
F
Q
A
A
M
L
A
G
D
Y
A
K
A
L
E
Y
Q
D
R
L
M
P
---
L
H
R
A
I
F
---
M
E
P
G
V
C
G
T
K
Y
A
L
S
K
T
R
G
C
-
N
R
K
-
V
R
S
P
L
M
S
T
L
E
P
A
T
E
A
A
I
D
A
A
L
K
H
A
G
L
M
N
75
PsiBlast_CBE
77.76
45%
-105
- C7 -
4I7U
4
DAPA_AGRFC
B:
[15-307]
M
F
K
G
S
I
P
A
L
I
T
P
F
T
D
N
G
A
V
D
E
Q
A
F
A
A
H
V
E
W
Q
I
A
E
G
S
N
G
L
V
P
V
G
T
T
G
E
S
P
T
L
S
H
D
E
H
K
R
V
V
E
L
C
I
E
V
A
A
K
R
V
P
V
I
A
G
A
G
S
N
N
T
D
E
A
I
E
L
A
L
H
A
Q
D
A
G
A
D
A
L
L
V
V
T
P
Y
Y
N
K
P
T
Q
K
G
L
F
A
H
F
S
A
V
A
E
A
V
K
L
P
I
V
I
Y
N
I
P
P
R
S
V
V
D
M
S
P
E
T
M
G
A
L
V
-
K
-
A
H
K
N
I
V
G
V
K
D
A
T
G
K
L
D
R
V
S
E
Q
R
I
S
C
-
G
K
D
-
F
I
Q
L
S
G
E
D
S
T
A
L
G
F
N
A
H
G
G
V
G
C
I
S
V
S
A
N
V
A
P
R
L
C
S
E
F
Q
A
A
M
L
A
G
D
Y
A
K
A
L
E
Y
Q
D
R
L
M
P
---
L
H
R
A
I
F
---
M
E
P
G
V
C
G
T
K
Y
A
L
S
K
T
R
G
C
-
N
R
K
-
V
R
S
P
L
M
S
T
L
E
P
A
T
E
A
A
I
D
A
A
L
K
H
A
G
L
M
N
90
PsiBlast_CBE
75.01
41%
-105
- C7 -
3DAQ
4
DAPA_STAAR
A:
[3-284]
L
F
E
G
V
G
V
A
L
T
T
P
F
-
T
N
N
K
V
N
L
E
A
L
K
A
H
V
N
F
L
L
E
N
N
A
Q
A
I
I
V
N
G
T
T
A
E
S
P
T
L
T
T
D
E
K
E
L
I
L
K
T
V
I
D
L
V
D
K
R
V
P
V
I
A
G
T
G
T
N
D
T
E
K
S
I
Q
A
S
I
Q
A
K
A
L
G
A
D
A
I
M
L
I
T
P
Y
Y
N
K
T
N
Q
R
G
L
V
K
H
F
E
A
I
A
D
A
V
K
L
P
V
V
L
Y
N
V
P
S
R
T
N
M
T
I
E
P
E
T
V
E
I
L
S
-
Q
-
H
-
P
Y
I
V
A
L
K
D
A
T
N
D
F
E
Y
L
E
E
V
K
K
R
I
-
D
T
N
S
F
A
L
Y
S
G
N
D
D
N
V
V
E
Y
Y
Q
R
G
G
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
A
L
Y
D
A
Q
Q
S
G
-----
L
D
I
Q
D
Q
F
K
P
I
G
T
L
L
S
A
L
S
---
V
D
I
N
P
I
P
I
K
A
L
T
S
Y
L
G
F
G
-
N
Y
E
-
L
R
L
P
L
-
V
S
L
E
D
T
D
T
K
V
L
R
E
A
Y
D
T
F
K
A
G
E
124
HHSearch
74.94
41%
-104
- C7 -
3DAQ
4
DAPA_STAAR
A:
[3-291]
L
F
E
G
V
G
V
A
L
T
T
P
F
T
N
-
N
K
V
N
L
E
A
L
K
A
H
V
N
F
L
L
E
N
N
A
Q
A
I
I
V
N
G
T
T
A
E
S
P
T
L
T
T
D
E
K
E
L
I
L
K
T
V
I
D
L
V
D
K
R
V
P
V
I
A
G
T
G
T
N
D
T
E
K
S
I
Q
A
S
I
Q
A
K
A
L
G
A
D
A
I
M
L
I
T
P
Y
Y
N
K
T
N
Q
R
G
L
V
K
H
F
E
A
I
A
D
A
V
K
L
P
V
V
L
Y
N
V
P
S
R
T
N
M
T
I
E
P
E
T
V
E
I
L
S
-
Q
-
H
-
P
Y
I
V
A
L
K
D
A
T
N
D
F
E
Y
L
E
E
V
K
K
R
I
D
T
N
S
-
F
A
L
Y
S
G
N
D
D
N
V
V
E
Y
Y
Q
R
G
G
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
A
L
Y
D
A
Q
Q
S
G
L
-----
D
I
Q
D
Q
F
K
P
---
I
G
T
L
L
S
A
L
S
V
D
I
N
P
I
P
I
K
A
L
T
S
Y
L
G
F
G
--
N
Y
E
L
R
L
P
L
-
V
S
L
E
D
T
D
T
K
V
L
R
E
A
Y
D
T
F
K
A
G
E
87
PsiBlast_CBE
74.64
41%
-105
- C7 -
3DAQ
4
DAPA_STAAR
D:
[3-284]
L
F
E
G
V
G
V
A
L
T
T
P
F
-
T
N
N
K
V
N
L
E
A
L
K
A
H
V
N
F
L
L
E
N
N
A
Q
A
I
I
V
N
G
T
T
A
E
S
P
T
L
T
T
D
E
K
E
L
I
L
K
T
V
I
D
L
V
D
K
R
V
P
V
I
A
G
T
G
T
N
D
T
E
K
S
I
Q
A
S
I
Q
A
K
A
L
G
A
D
A
I
M
L
I
T
P
Y
Y
N
K
T
N
Q
R
G
L
V
K
H
F
E
A
I
A
D
A
V
K
L
P
V
V
L
Y
N
V
P
S
R
T
N
M
T
I
E
P
E
T
V
E
I
L
S
-
Q
-
H
-
P
Y
I
V
A
L
K
D
A
T
N
D
F
E
Y
L
E
E
V
K
K
R
I
-
D
T
N
S
F
A
L
Y
S
G
N
D
D
N
V
V
E
Y
Y
Q
R
G
G
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
A
L
Y
D
A
Q
Q
S
G
-----
L
D
I
Q
D
Q
F
K
P
IGT
L
L
S
A
L
S
---
V
D
I
N
P
I
P
I
K
A
L
T
S
Y
L
G
F
G
-
N
Y
E
-
L
R
L
P
L
-
V
S
L
E
D
T
D
T
K
V
L
R
E
A
Y
D
T
F
K
A
G
E
88
PsiBlast_CBE
74.15
41%
-105
- C7 -
3DAQ
5
DAPA_STAAR
C:
[3-284]
L
F
E
G
V
G
V
A
L
T
T
P
F
-
T
N
N
K
V
N
L
E
A
L
K
A
H
V
N
F
L
L
E
N
N
A
Q
A
I
I
V
N
G
T
T
A
E
S
P
T
L
T
T
D
E
K
E
L
I
L
K
T
V
I
D
L
V
D
K
R
V
P
V
I
A
G
T
G
T
N
D
T
E
K
S
I
Q
A
S
I
Q
A
K
A
L
G
A
D
A
I
M
L
I
T
P
Y
Y
N
K
T
N
Q
R
G
L
V
K
H
F
E
A
I
A
D
A
V
K
L
P
V
V
L
Y
N
V
P
S
R
T
N
M
T
I
E
P
E
T
V
E
I
L
S
-
Q
-
H
-
P
Y
I
V
A
L
K
D
A
T
N
D
F
E
Y
L
E
E
V
K
K
R
I
-
D
T
N
S
F
A
L
Y
S
G
N
D
D
N
V
V
E
Y
Y
Q
R
G
G
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
A
L
Y
D
A
Q
Q
S
G
-----
L
D
I
Q
D
Q
F
K
P
IGT
L
L
S
A
L
S
---
V
D
I
N
P
I
P
I
K
A
L
T
S
Y
L
G
F
G
-
N
Y
E
-
L
R
L
P
L
-
V
S
L
E
D
T
D
T
K
V
L
R
E
A
Y
D
T
F
K
A
G
E
89
PsiBlast_CBE
73.99
41%
-104
- C7 -
3DAQ
5
DAPA_STAAR
B:
[3-284]
L
F
E
G
V
G
V
A
L
T
T
P
F
-
T
N
N
K
V
N
L
E
A
L
K
A
H
V
N
F
L
L
E
N
N
A
Q
A
I
I
V
N
G
T
T
A
E
S
P
T
L
T
T
D
E
K
E
L
I
L
K
T
V
I
D
L
V
D
K
R
V
P
V
I
A
G
T
G
T
N
D
T
E
K
S
I
Q
A
S
I
Q
A
K
A
L
G
A
D
A
I
M
L
I
T
P
Y
Y
N
K
T
N
Q
R
G
L
V
K
H
F
E
A
I
A
D
A
V
K
L
P
V
V
L
Y
N
V
P
S
R
T
N
M
T
I
E
P
E
T
V
E
I
L
S
-
Q
-
H
-
P
Y
I
V
A
L
K
D
A
T
N
D
F
E
Y
L
E
E
V
K
K
R
I
-
D
T
N
S
F
A
L
Y
S
G
N
D
D
N
V
V
E
Y
Y
Q
R
G
G
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
A
L
Y
D
A
Q
Q
S
G
-----
L
D
I
Q
D
Q
F
K
P
IGT
L
L
S
A
L
S
---
V
D
I
N
P
I
P
I
K
A
L
T
S
Y
L
G
F
G
-
N
Y
E
-
L
R
L
P
L
-
V
S
L
E
D
T
D
T
K
V
L
R
E
A
Y
D
T
F
K
A
G
E
92
PsiBlast_CBE
73.59
40%
-106
- C7 -
3DI1
1
DAPA_STAAC
A:
[4-285]
L
F
E
G
V
G
V
A
L
T
T
P
F
-
T
N
N
K
V
N
I
E
A
L
K
T
H
V
N
F
L
L
E
N
N
A
Q
A
I
I
V
N
G
T
T
A
E
S
P
T
L
T
T
D
E
K
E
R
I
L
K
T
V
I
D
L
V
D
K
R
V
P
V
I
A
G
T
G
T
N
D
T
E
K
S
I
Q
A
S
I
Q
A
K
A
L
G
A
D
A
I
M
L
I
T
P
Y
Y
N
K
T
N
Q
R
G
L
V
K
H
F
E
A
I
A
D
A
V
K
L
P
V
V
L
Y
N
V
P
S
R
T
N
M
T
I
E
P
E
T
V
E
I
L
S
-
Q
-
H
-
P
Y
I
V
A
L
K
D
A
T
N
D
F
E
Y
L
E
E
V
K
K
R
I
-
D
T
N
S
F
A
L
Y
S
G
N
D
D
N
V
V
E
Y
Y
Q
R
G
G
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
A
L
Y
D
A
Q
Q
S
G
-----
L
D
I
Q
D
Q
F
K
P
I
G
T
L
L
S
A
L
S
---
V
D
I
N
P
I
P
I
K
A
L
T
S
Y
L
G
F
G
-
N
Y
E
-
L
R
L
P
L
-
V
S
L
E
D
T
D
T
K
V
L
R
E
T
Y
D
T
F
K
A
--
93
PsiBlast_CBE
72.28
40%
-105
- C7 -
3DI0
1
DAPA_STAAC
B:
[4-285]
L
F
E
G
V
G
V
A
L
T
T
P
F
-
T
N
N
K
V
N
I
E
A
L
K
T
H
V
N
F
L
L
E
N
N
A
Q
A
I
I
V
N
G
T
T
A
E
S
P
T
L
T
T
D
E
K
E
R
I
L
K
T
V
I
D
L
V
D
K
R
V
P
V
I
A
G
T
G
T
N
D
T
E
K
S
I
Q
A
S
I
Q
A
K
A
L
G
A
D
A
I
M
L
I
T
P
Y
Y
N
K
T
N
Q
R
G
L
V
K
H
F
E
A
I
A
D
A
V
K
L
P
V
V
L
Y
N
V
P
S
R
T
N
M
T
I
E
P
E
T
V
E
I
L
S
-
Q
-
H
-
P
Y
I
V
A
L
K
D
A
T
N
D
F
E
Y
L
E
E
V
K
K
R
I
-
D
T
N
S
F
A
L
Y
S
G
N
D
D
N
V
V
E
Y
Y
Q
R
G
G
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
A
L
Y
D
A
Q
Q
S
G
-----
L
D
I
Q
D
Q
F
K
P
IGT
L
L
S
A
L
S
---
V
D
I
N
P
I
P
I
K
A
L
T
S
Y
L
G
F
G
-
N
Y
E
-
L
R
L
P
L
-
V
S
L
E
D
T
D
T
K
V
L
R
E
T
Y
D
T
F
K
A
G
E
94
PsiBlast_CBE
72.01
40%
-107
- C7 -
3DI0
1
DAPA_STAAC
A:
[4-285]
L
F
E
G
V
G
V
A
L
T
T
P
F
-
T
N
N
K
V
N
I
E
A
L
K
T
H
V
N
F
L
L
E
N
N
A
Q
A
I
I
V
N
G
T
T
A
E
S
P
T
L
T
T
D
E
K
E
R
I
L
K
T
V
I
D
L
V
D
K
R
V
P
V
I
A
G
T
G
T
N
D
T
E
K
S
I
Q
A
S
I
Q
A
K
A
L
G
A
D
A
I
M
L
I
T
P
Y
Y
N
K
T
N
Q
R
G
L
V
K
H
F
E
A
I
A
D
A
V
K
L
P
V
V
L
Y
N
V
P
S
R
T
N
M
T
I
E
P
E
T
V
E
I
L
S
-
Q
-
H
-
P
Y
I
V
A
L
K
D
A
T
N
D
F
E
Y
L
E
E
V
K
K
R
I
-
D
T
N
S
F
A
L
Y
S
G
N
D
D
N
V
V
E
Y
Y
Q
R
G
G
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
A
L
Y
D
A
Q
Q
S
G
-----
L
D
I
Q
D
Q
F
K
P
I
G
T
L
L
S
A
L
S
---
V
D
I
N
P
I
P
I
K
A
L
T
S
Y
L
G
F
G
-
N
Y
E
-
L
R
L
P
L
-
V
S
L
E
D
T
D
T
K
V
L
R
E
T
Y
D
T
F
K
A
G
-
91
PsiBlast_CBE
71.67
40%
-103
- C7 -
3DI1
1
DAPA_STAAC
B:
[4-285]
L
F
E
G
V
G
V
A
L
T
T
P
F
-
T
N
N
K
V
N
I
E
A
L
K
T
H
V
N
F
L
L
E
N
N
A
Q
A
I
I
V
N
G
T
T
A
E
S
P
T
L
T
T
D
E
K
E
R
I
L
K
T
V
I
D
L
V
D
K
R
V
P
V
I
A
G
T
G
T
N
D
T
E
K
S
I
Q
A
S
I
Q
A
K
A
L
G
A
D
A
I
M
L
I
T
P
Y
Y
N
K
T
N
Q
R
G
L
V
K
H
F
E
A
I
A
D
A
V
K
L
P
V
V
L
Y
N
V
P
S
R
T
N
M
T
I
E
P
E
T
V
E
I
L
S
-
Q
-
H
-
P
Y
I
V
A
L
K
D
A
T
N
D
F
E
Y
L
E
E
V
K
K
R
I
-
D
T
N
S
F
A
L
Y
S
G
N
D
D
N
V
V
E
Y
Y
Q
R
G
G
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
A
L
Y
D
A
Q
Q
S
G
-----
L
D
I
Q
D
Q
F
K
P
I
G
T
L
L
S
A
L
S
---
V
D
I
N
P
I
P
I
K
A
L
T
S
Y
L
G
F
G
-
N
Y
E
-
L
R
L
P
L
-
V
S
L
E
D
T
D
T
K
V
L
R
E
T
Y
D
T
F
K
A
--