@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA1113: (2016-01-26 )
MPAILSSRQRIALRLAWRFMAPYRWRMLGALVALLFTAAITLSLGQGIRLLVDQGFLTASPELLNRYILLFFVLVLGLAVGTFVRFYLVSWIGERFVADIRKRVFDHLIELHPGFYETNRSSEIQSRLTADTTLLQTVIGSSLSMALRNALMLVGGVLLMFVTNAKLTSIVVLALPLVIAPILLFGRRVRSLSRESQDRVADVGSYVGETLGQIKTVQAYNHQAQDRQRFAGTVERAFDTARKRIAQRAWLITVVIVLVLGAVGIMLWVGGRDVIAGSISAGELAAFVFYSLIVGMAFGTLSEVIGELQRAAGAAERIAELLRARSEIRPPAQPRKLAARVSGRIELQAVRFAYPTRPEHWAIDDISLAVEPGETLALVGPSGAGKSTLFDLLLRFFDPQQGRLLLDGQPIVELDPADLRRSFALVSQNPALFFGSVEENIRYGRPHASAAEVEAAARAAHAHEFILGLPQGYATHLGEGGIGLSGGQRQRLAIARALLVDAPVLLLDEATSALDAESEHLIQQALPGLMSGRTTLVIAHRLATVQSADRIAVIDQGRLVAIGSHARLIAENPLYARLAELQFAAGGR
Atome Classification :
(46 SA)
.........10........20........30........40..----......50..----......60-.---........70--..-......----.80........90........100.......110......--.120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250...-....260.---------..--------...--------.270.......280.....-..290....-.-..300.....---..310.......320.......--330-.--...---.....340.-----.......350..-.....360.-......370.......380.......390.......400-.........410.......420.......430.......440..-..-.---.-.---450.........460.......470.......480.......490.......500.......510.......520....---...530.........540.......550.......560.......570-........580......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MP
A
I
L
S
S
R
Q
R
I
A
L
R
L
A
W
R
FMA
P
Y
R
W
R
M
L
G
A
L
V
A
L
L
F
T
A
A
I
T
L
S----LGQ
G
I
R
L
L
VD----QGFLTA
S
--
P
---
E
L
L
N
R
Y
I
L
L
---
F
F
-
V
L
V
L
G
L
----
A
V
G
T
F
V
R
F
Y
L
V
S
W
I
G
E
R
F
V
A
D
I
R
K
R
V
F
D
H
L
I
E
LHPGFYET--NR
S
S
E
I
Q
S
R
LT
A
D
T
T
L
L
Q
T
V
I
G
S
S
L
S
M
A
L
R
N
A
L
M
L
V
G
G
V
L
L
M
F
VTNAKL
T
S
I
V
V
L
A
L
P
L
V
I
A
P
I
L
L
F
G
R
R
V
R
S
L
S
R
E
S
Q
D
R
V
A
D
V
G
S
Y
V
G
E
T
L
G
Q
I
K
T
V
Q
A
YN
H
Q
A
Q
D
R
Q
R
F
A
G
T
V
E
R
A
F
D
T
A
R
K
R
I
A
Q
R
A
W
L
I
T
V
V
-
I
V
L
V
L
G
A
V
---------
G
I
--------
M
L
W
--------VG
G
R
D
V
I
AGSI
S
A
G
E
L
A
A
F
-
V
F
Y
S
L
I
V
G
M
-
A
-
F
G
T
L
S
E
V
I
G
E
---
L
Q
R
AA
G
A
A
E
R
I
A
E
L
L
R
A
R
S
EIR--P---P--A
Q
P
---
R
K
L
A
A
R
-VS-----G
R
I
E
L
Q
A
V
R
F
AY-PTRPEHWAI-
D
D
I
S
L
A
VEPG
E
T
L
A
L
VGPSGA
G
K
S
T
L
F
D
L
L
L
R
FFDPQ---Q
G
R
L
L
LDGQ
P
I
V
EL
D
P
A
D
L
R
R
S
F
A
LVSQNP
A
L
F
F
GS
V
E
ENIRYG-RP-H---A-
S
---
A
--
A
E
V
E
A
A
A
R
A
A
H
A
H
E
F
I
LGLP
Q
G
Y
A
T
HLGEGGIGLSGG
Q
R
Q
R
L
A
I
A
R
A
L
LVDA
P
V
L
L
LDEATSALD
A
E
S
E
H
L
I
Q
Q
A
L
---
P
G
L
M--SG
R
T
T
L
V
I
A
H
R
L
A
T
VQSA
D
R
I
A
V
IDQ
G
R
L
V
A
IGSH
A
R
L
IAE--N
P
L
Y
A
R
L
A
E
L
Q
FAAGGR
105
HHSearch
88.40
36%
-115
- C2 -
3ZDQ
6
ABCBA_HUMAN
A:
[6-572]
-----------
E
A
R
K
L
L
G
L
A
Y
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
----
A
P
F
F
L
G
K
I
I
D
----
V
I
Y
T
N
P
T
--
V
DY
S
D
N
L
T
R
L
C
L
G
---
L
S
-
A
V
F
L
C
G
----
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
--
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
--
G
-
A
T
G
L
S
G
N
L
I
V
-------
L
S
--------
V
L
Y
--------
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
-
L
M
Y
A
F
W
V
G
I
-
S
-
I
G
G
L
S
S
F
Y
S
E
---
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
--
F
---
N
--
E
G
V
---
I
L
N
E
K
S
-
F
Q
-----
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
R
P
E
V
P
I
F
-
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
D
-
D
PSS
V
-
T
---
A
--
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
---
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P------------------
2
PsiBlast_PDB
87.76
36%
-116
- C2 -
4AYX
7
ABCBA_HUMAN
A:
[16-574]
---------------------
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
----
N
P
T
V
D
Y
S
--
D
---
N
L
T
R
L
C
L
G
L
---
S
A
-
V
F
L
C
G
A
----
A
A
N
A
-
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
--
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
---------
F
G
A
T
---------
G
L
S
G
N
L
I
V
L
S
V
L
Y
--------
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
-
L
M
Y
A
F
W
V
G
I
-
S
-
I
G
G
L
S
S
F
Y
S
E
---
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
-----
R
--
E
---
P
--
K
L
P
---
F
N
E
G
V
I
-
L
N
EKSFQ
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
R
P
E
V
P
I
F
-
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
D
-
D
---
P
-
S
SVT
A
--
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
---
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P-
N
G
---------------
3
PsiBlast_PDB
87.44
36%
-114
- C2 -
3ZDQ
6
ABCBA_HUMAN
A:
[16-572]
---------------------
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
----
N
P
T
V
D
Y
S
--
D
---
N
L
T
R
L
C
L
G
L
---
S
A
-
V
F
L
C
G
A
----
A
A
N
A
-
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
--
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
---------
F
G
A
T
---------
G
L
S
G
N
L
I
V
L
S
V
L
Y
--------
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
-
L
M
Y
A
F
W
V
G
I
-
S
-
I
G
G
L
S
S
F
Y
S
E
---
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
-----
R
--
E
---
P
--
K
L
P
---
F
N
E
G
V
I
-
L
N
EKSFQ
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
R
P
E
V
P
I
F
-
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
D
-
D
---
P
-
S
SVT
A
--
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
---
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P------------------
21
PsiBlast_CBE
87.31
34%
-113
- C2 -
2ONJ
4
Y1866_STAAM
B:
[7-576]
-----------------
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
----
I
P
L
L
I
K
Y
A
I
D
GVIN
N
H
A
L
T
T
D
--
E
---
K
V
H
H
L
T
I
A
I
GIA
L
F
-
I
F
V
I
V
R
----
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
--
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
----------
I
--------
V
I
G
--------
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
-
V
G
Y
---
L
E
L
-
L
-
F
G
P
L
R
R
L
V
A
S
FTT
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
K
--
N
---
G
VG
A
Q
P
---
I
E
I
K
----
Q
-----
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
D
N
-
E
A
P
I
L
-
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
P
-
T
---
A
-
T
---
D
--
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
---
D
V
L
S
--
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
----
17
PsiBlast_PDB
87.05
29%
-126
- C2 -
3QF4
1
Y288_THEMA
B:
[24-592]
-----------
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
----
S
P
Y
L
I
G
K
T
I
D
----
V
V
F
V
P
R
R
--
F
---
D
L
L
P
R
Y
M
L
I
---
L
G
-
T
I
Y
A
L
T
----
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
--
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
----
D
R
V
N
E
S
L
R
K
-
V
G
T
K
A
Q
I
F
S
G
V
-
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
--------
G
G
W
--------
L
A
L
K
D
I
I
----
T
V
G
T
I
A
T
F
-
I
G
Y
S
R
Q
F
T
R
-
P
-
L
N
E
L
S
N
Q
F
N
M
---
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
--------
K
--
D
D
P
---
D
A
V
E
L
R
E
V
R
-----
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
K
K
P
--
V
L
-
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
---
A
-
T
---
D
--
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
---
W
K
L
M
--
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
Y
G
L
V
V
E
1
PsiBlast_PDB
86.92
36%
-111
- C2 -
4AYT
8
ABCBA_HUMAN
A:
[16-567]
---------------------
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
----
N
P
T
V
D
Y
S
--
D
---
N
L
T
R
L
C
L
G
L
---
S
A
-
V
F
L
C
G
A
----
A
A
N
A
-
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
--
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
---------
F
G
A
T
---------
G
L
S
G
N
L
I
V
L
S
V
L
Y
--------
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
-
L
M
Y
A
F
W
V
G
I
-
S
-
I
G
G
L
S
S
F
Y
S
E
---
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
-----
R
--
E
---
P
--
K
L
P
---
F
N
E
G
V
I
-
L
N
EKSFQ
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
R
P
E
V
P
I
F
-
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
D
-
D
---
P
-
S
SVT
A
--
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
---
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-----------------------
18
PsiBlast_PDB
86.87
29%
-127
- C2 -
4Q4A
1
Y288_THEMA
B:
[24-592]
-----------
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
----
S
P
Y
L
I
G
K
T
I
D
----
V
V
F
V
P
R
R
--
F
---
D
L
L
P
R
Y
M
L
I
---
L
G
-
T
I
Y
A
L
T
----
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
--
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
----
D
R
V
N
E
S
L
R
K
-
V
G
T
K
A
Q
I
F
S
G
V
-
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
--------
G
G
W
--------
L
A
L
K
D
I
I
----
T
V
G
T
I
A
T
F
-
I
G
Y
S
R
Q
F
T
R
-
P
-
L
N
E
L
S
N
Q
F
N
M
---
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
--------
K
--
D
D
P
---
D
A
V
E
L
R
E
V
R
-----
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
K
K
P
--
V
L
-
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
---
A
-
T
---
D
--
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
---
W
K
L
M
--
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
Y
G
L
---
22
PsiBlast_CBE
86.85
34%
-113
- C2 -
2HYD
3
Y1866_STAAM
B:
[7-576]
-----------------
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
----
I
P
L
L
I
K
Y
A
I
D
GVIN
N
H
A
L
T
T
D
--
E
---
K
V
H
H
L
T
I
A
I
GIA
L
F
-
I
F
V
I
V
R
----
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
--
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
----------
I
--------
V
I
G
--------
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
-
V
G
Y
---
L
E
L
-
L
-
F
G
P
L
R
R
L
V
A
S
FTT
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
K
--
N
---
G
VG
A
Q
P
---
I
E
I
K
----
Q
-----
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
D
N
-
E
A
P
I
L
-
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
P
-
T
---
A
-
T
---
D
--
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
---
D
V
L
S
--
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
----
6
PsiBlast_PDB
86.71
34%
-112
- C2 -
2ONJ
4
Y1866_STAAM
A:
[7-576]
-----------------
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
----
I
P
L
L
I
K
Y
A
I
D
GVIN
N
H
A
L
T
T
D
--
E
---
K
V
H
H
L
T
I
A
I
G
I
A
L
F
-
I
F
V
I
V
R
----
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
--
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
----------
I
--------
V
I
G
--------
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
-
V
G
Y
---
L
E
L
-
L
-
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
K
--
N
---
G
VG
A
Q
P
---
I
E
I
K
----
Q
-----
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
D
N
-
E
A
P
I
L
-
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
P
-
T
---
A
-
T
---
D
--
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
---
D
V
L
S
--
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
----
5
PsiBlast_PDB
86.17
34%
-112
- C2 -
2HYD
3
Y1866_STAAM
A:
[7-576]
-----------------
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
----
I
P
L
L
I
K
Y
A
I
D
GVIN
N
H
A
L
T
T
D
--
E
---
K
V
H
H
L
T
I
A
I
G
I
A
L
F
-
I
F
V
I
V
R
----
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
--
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
----------
I
--------
V
I
G
--------
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
-
V
G
Y
---
L
E
L
-
L
-
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
K
--
N
---
G
VG
A
Q
P
---
I
E
I
K
----
Q
-----
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
D
N
-
E
A
P
I
L
-
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
P
-
T
---
A
-
T
---
D
--
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
---
D
V
L
S
--
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
----
19
PsiBlast_PDB
86.00
29%
-126
- C2 -
4Q4H
-
Y288_THEMA
B:
[24-592]
-----------
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
----
S
P
Y
L
I
G
K
T
I
D
----
V
V
F
V
P
R
R
--
F
---
D
L
L
P
R
Y
M
L
I
---
L
G
-
T
I
Y
A
L
T
----
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
--
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
----
D
R
V
N
E
S
L
R
K
-
V
G
T
K
A
Q
I
F
S
G
V
-
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
--------
G
G
W
--------
L
A
L
K
D
I
I
----
T
V
G
T
I
A
T
F
-
I
G
Y
S
R
Q
F
T
R
-
P
-
L
N
E
L
S
N
Q
F
N
M
---
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
--------
K
--
D
D
P
---
D
A
V
E
L
R
E
V
R
-----
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
K
K
P
--
V
L
-
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
---
A
-
T
---
D
--
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
---
W
K
L
M
--
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
Y
G
----
4
PsiBlast_PDB
85.77
36%
-116
- C2 -
4AYW
3
ABCBA_HUMAN
A:
[47-598]
---------------------
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
----
N
P
T
V
D
Y
S
--
D
---
N
L
T
R
L
C
L
G
L
---
S
A
-
V
F
L
C
G
A
----
A
A
N
A
-
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
--
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
---------
F
G
A
T
---------
G
L
S
G
N
L
I
V
L
S
V
L
Y
--------
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
-
L
M
Y
A
F
W
V
G
I
-
S
-
I
G
G
L
S
S
F
Y
S
E
---
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
-----
R
--
E
---
P
--
K
L
P
---
F
N
E
G
V
I
-
L
N
EKSFQ
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
R
P
E
V
P
I
F
-
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
D
-
D
---
P
-
S
SVT
A
--
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
E
A
L
---
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
H
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-----------------------
106
HHSearch
84.96
32%
-118
- C2 -
3WMG
5
?
A:
[29-598]
--------------------------
I
V
I
G
F
I
A
S
I
L
E
G
A
T
L
P
A
----
F
A
I
V
F
G
R
M
F
Q
----
V
F
T
K
S
K
S
Q
I
E
---
G
E
T
W
K
Y
S
V
G
---
F
V
-
G
I
G
V
F
E
----
F
I
V
A
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
--
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
S
F
S
K
L
-
G
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
V
L
I
A
L
S
P
L
V
V
L
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
D
G
L
F
F
--
G
-
L
S
M
L
V
I
F
C
V
Y
-------
A
L
--------
A
L
W
--------
W
G
G
Q
L
I
A
R
G
S
L
N
L
G
N
L
L
T
A
-
F
F
S
A
I
L
G
F
M
-
G
-
V
G
Q
A
A
Q
V
W
P
D
---
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
V
P
Q
Y
R
--
R
---
P
--
D
P
G
A
E
V
V
T
Q
P
L
V
-
L
K
-----
Q
G
I
V
F
E
N
V
H
F
R
Y
-
P
T
R
M
N
V
E
V
L
-
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
T
I
R
D
N
I
L
Y
G
-
K
R
-
D
---
A
-
T
---
D
--
E
E
V
I
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
---
D
R
M
M
A
S
D
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
L
GP
S
G
F
Y
Y
Q
L
V
E
K
Q
L
A
S
---
13
PsiBlast_PDB
83.15
35%
-116
- C2 -
4F4C
2
PGP1_CAEEL
A:
[796-1306]
-------------------------------------------------------------------------------
W
A
L
M
---
F
L
-
V
L
A
A
A
Q
----
G
I
C
S
F
L
M
T
F
F
M
G
I
A
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
V
L
S
Q
H
I
G
F
F
D
S
PQ
N
A
S
G
K
I
S
T
R
L
A
T
D
V
P
N
L
R
T
A
I
D
F
R
F
S
T
V
I
T
T
L
V
S
M
V
A
G
I
G
L
A
F
F
Y
G
W
Q
M
A
L
L
I
I
A
I
L
P
I
V
A
F
G
Q
Y
L
R
G
R
R
F
T
G
K
N
V
K
S
A
S
E
F
A
D
S
G
K
I
A
I
E
A
I
E
N
V
R
T
V
Q
A
L
A
R
E
D
T
F
Y
E
N
F
C
----
E
K
L
D
I
P
H
K
E
A
I
K
E
A
F
I
Q
G
-----
L
S
Y
G
C
A
---------
S
S
--------
V
L
Y
L
L
N
T
C
A
Y
R
M
G
L
A
L
I
I
T
D
P
P
T
M
Q
P
M
R
V
L
R
V
M
Y
A
I
T
I
S
T
-
S
T
L
G
F
A
T
S
Y
F
P
E
---
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
K
I
S
K
I
D
--
S
LSL
A
--
G
E
K
---
K
K
L
Y
----------
G
K
V
I
F
K
N
V
R
F
A
Y
-
P
E
R
P
E
I
E
I
L
-
K
G
L
S
F
S
V
E
P
G
Q
T
L
A
L
V
G
P
S
G
C
G
K
S
T
V
V
A
L
L
E
R
F
Y
D
T
L
---
G
G
E
I
F
I
D
G
S
E
I
K
T
L
N
P
E
H
T
R
S
Q
I
A
I
V
S
Q
E
P
T
L
F
D
C
S
I
A
E
N
I
I
Y
G
-
L
D
-
P
---
S
-
S
---
V
T
M
A
Q
V
E
E
A
A
R
L
A
N
I
H
N
F
I
A
E
L
P
E
G
F
E
T
R
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
---
D
R
A
R
--
E
G
R
T
C
I
V
I
A
H
R
L
N
T
V
M
N
A
D
C
I
A
V
V
S
N
G
T
I
I
E
K
G
T
H
T
Q
L
M
S
E
--
K
----------------
24
PsiBlast_CBE
82.90
33%
-109
- C2 -
3B60
2
MSBA_SALTY
C:
[12-580]
-----------
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
----
M
L
S
L
L
K
P
L
L
D
----
D
G
F
G
K
T
----------
D
R
S
V
L
L
---
W
M
P
L
V
V
I
G
L
MILR
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
--
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
-
Q
L
I
A
S
L
A
L
---------
A
F
--------
V
L
Y
--------
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
--
V
F
S
S
M
I
A
L
M
R
P
-
L
K
S
L
T
N
V
N
A
Q
---
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
--------
K
--
D
E
G
---
K
R
V
I
D
R
-
A
T
-----
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
G
R
-
E
V
P
A
L
-
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
-
E
---
E
Y
S
---
R
--
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
---
D
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
----
25
PsiBlast_CBE
82.87
33%
-109
- C2 -
3B60
2
MSBA_SALTY
B:
[12-580]
-----------
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
----
M
L
S
L
L
K
P
L
L
D
----
D
G
F
G
K
T
----------
D
R
S
V
L
L
---
W
M
P
L
V
V
I
G
L
MILR
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
--
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
-
Q
L
I
A
S
L
A
L
---------
A
F
--------
V
L
Y
--------
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
--
V
F
S
S
M
I
A
L
M
R
P
-
L
K
S
L
T
N
V
N
A
Q
---
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
--------
K
--
D
E
G
---
K
R
V
I
D
R
-
A
T
-----
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
G
R
-
E
V
P
A
L
-
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
-
E
---
E
Y
S
---
R
--
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
---
D
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
----
11
PsiBlast_PDB
82.87
33%
-110
- C2 -
3B60
2
MSBA_SALTY
A:
[12-580]
-----------
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
----
M
L
S
L
L
K
P
L
L
D
----
D
G
F
G
K
T
----------
D
R
S
V
L
L
---
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
--
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
-
Q
L
I
A
S
L
A
L
---------
A
F
--------
V
L
Y
--------
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
--
V
F
S
S
M
I
A
L
M
R
P
-
L
K
S
L
T
N
V
N
A
Q
---
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
--------
K
--
D
E
G
---
K
R
V
I
D
R
-
A
T
-----
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
G
R
-
E
V
P
A
L
-
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
-
E
---
E
Y
S
---
R
--
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
---
D
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
----
23
PsiBlast_CBE
82.47
33%
-109
- C2 -
3B60
2
MSBA_SALTY
D:
[12-580]
-----------
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
----
M
L
S
L
L
K
P
L
L
D
----
D
G
F
G
K
T
----------
D
R
S
V
L
L
---
W
M
P
L
V
V
I
G
L
MILR
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
--
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
-
Q
L
I
A
S
L
A
L
---------
A
F
--------
V
L
Y
--------
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
--
V
F
S
S
M
I
A
L
M
R
P
-
L
K
S
L
T
N
V
N
A
Q
---
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
--------
K
--
D
E
G
---
K
R
V
I
D
R
-
A
T
-----
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
G
R
-
E
V
P
A
L
-
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
-
E
---
E
Y
S
---
R
--
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
---
D
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
----
125
Fugue
81.88
32%
-110
- C2 -
3B60
2
MSBA_SALTY
A:
[10-581]
---------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
----
M
L
S
L
L
K
P
L
L
D
----
D
G
F
G
K
T
D
--
R
---
S
V
L
L
W
M
P
L
V
---
V
I
-
G
L
M
I
L
R
----
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
--
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
-
Q
L
I
A
S
L
A
L
---------
A
F
--------
V
L
Y
--------
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
-
F
S
S
M
I
A
L
M
R
-
P
-
L
K
S
L
T
N
V
N
A
Q
---
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
D
--
E
---
G
--
K
R
V
---
I
D
---
R
-
A
T
-----
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
G
R
E
V
P
-
A
L
-
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
E
E
---
Y
-
S
---
R
--
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
---
D
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
----
103
HHSearch
81.83
32%
-110
- C2 -
3B60
2
MSBA_SALTY
A:
[10-581]
---------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
----
M
L
S
L
L
K
P
L
L
D
----
D
G
F
G
K
T
D
--
R
---
S
V
L
L
W
M
P
L
V
---
V
I
-
G
L
M
I
L
R
----
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
--
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
--
P
-
I
I
Q
L
I
A
S
L
A
L
-------
A
F
--------
V
L
Y
--------
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
-
F
S
S
M
I
A
L
M
R
-
P
-
L
K
S
L
T
N
V
N
A
Q
---
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
D
--
E
---
G
--
K
------
R
V
I
D
R
-
A
T
-----
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
G
R
E
-
V
P
A
L
-
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
-
E
E--
Y
-
S
---
R
--
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
---
D
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
----
40
PsiBlast_CBE
59.87
46%
-117
- C2 -
2PMK
1
A:
[4-241]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
S
P
--
V
I
L
-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
---
V
--
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----
52
PsiBlast_CBE
58.77
45%
-109
- C2 -
1XEF
3
D:
[2-239]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
---
K
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
---
V
--
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----
34
PsiBlast_CBE
58.75
46%
-103
- C2 -
3NH9
3
A:
[26-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
M
F
D
L
L
K
E
E
T
E
V
K
D
L
P
---
G
--
A
G
P
---
L
R
F
Q
----
K
-----
G
R
I
E
F
E
N
V
H
F
S
Y
-
A
D
G
R
E
--
T
L
-
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
-
R
V
-
T
---
A
-
G
---
N
--
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
---
A
K
V
C
--
A
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
G
V
Y
A
D
M
W
Q
L
Q
Q
G
Q
---
54
PsiBlast_CBE
58.57
45%
-112
- C2 -
1XEF
3
HLYBP_ECOLX
B:
[2-239]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
---
K
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
---
V
--
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----
43
PsiBlast_CBE
58.40
45%
-114
- C2 -
2FGK
2
HLYBP_ECOLX
B:
[8-245]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
---
K
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
---
V
--
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----
41
PsiBlast_CBE
58.31
45%
-113
- C2 -
2FGK
2
D:
[8-245]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
---
K
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
---
V
--
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----
53
PsiBlast_CBE
58.18
45%
-113
- C2 -
1XEF
3
HLYBP_ECOLX
C:
[2-239]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
---
K
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
---
V
--
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----
32
PsiBlast_CBE
57.72
46%
-104
- C2 -
3NHB
3
A:
[26-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
M
F
D
L
L
K
E
E
T
E
V
K
D
L
P
---
G
--
A
G
P
---
L
R
F
Q
----
K
-----
G
R
I
E
F
E
N
V
H
F
S
Y
-
A
D
-
R
E
--
T
L
-
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
-
R
V
-
T
---
A
-
G
---
N
--
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
---
A
K
V
C
--
A
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
G
V
Y
A
D
M
W
Q
L
Q
Q
G
Q
---
48
PsiBlast_CBE
57.56
45%
-108
- C2 -
2FGJ
2
HLYBP_ECOLX
C:
[8-245]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
---
K
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
---
V
--
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----
47
PsiBlast_CBE
57.48
45%
-112
- C2 -
2FGJ
2
D:
[8-245]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
---
K
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
---
V
--
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----
44
PsiBlast_CBE
57.45
45%
-111
- C2 -
2FGK
2
HLYBP_ECOLX
A:
[8-245]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
---
K
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
---
V
--
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----
50
PsiBlast_CBE
57.39
45%
-108
- C2 -
2FGJ
2
HLYBP_ECOLX
A:
[8-245]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
---
K
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
---
V
--
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----
33
PsiBlast_CBE
57.14
46%
-104
- C2 -
3NHA
4
A:
[26-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
M
F
D
L
L
K
E
E
T
E
V
K
DL
P
---
G
--
A
G
P
---
L
R
F
Q
----
K
-----
G
R
I
E
F
E
N
V
H
F
S
Y
-
A
D
-
R
E
--
T
L
-
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
-
R
V
-
T
---
A
-
G
---
N
--
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
---
A
K
V
C
--
A
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
G
V
Y
A
D
M
W
Q
L
Q
Q
G
Q
---
55
PsiBlast_CBE
56.84
45%
-107
- C2 -
1XEF
3
HLYBP_ECOLX
A:
[2-239]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
---
K
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
---
V
--
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----
49
PsiBlast_CBE
56.66
45%
-110
- C2 -
2FGJ
2
HLYBP_ECOLX
B:
[8-245]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
---
K
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
---
V
--
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----
42
PsiBlast_CBE
56.42
45%
-110
- C2 -
2FGK
2
HLYBP_ECOLX
C:
[8-245]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
---
K
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
---
V
--
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----
77
PsiBlast_CBE
55.84
39%
-109
- C2 -
2IXG
2
A:
[12-255]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-
M
K
-----
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
H
P
N
V
Q
V
L
-
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
-
L
T
-
R
---
T
P
T
---
M
--
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
A
V
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
ES
P
E
W
A
--
S
-
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
R
S
M
V
E
A
L
------
69
PsiBlast_CBE
55.83
40%
-108
- C2 -
2IXF
5
TAP1_RAT
A:
[12-255]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-
M
K
-----
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
H
P
N
V
Q
V
L
-
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
-
L
T
-
R
---
T
P
T
---
M
--
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
ES
P
E
W
A
--
S
-
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
R
S
M
V
E
A
-------
68
PsiBlast_CBE
55.57
40%
-109
- C2 -
2IXF
4
TAP1_RAT
B:
[12-255]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-
M
K
-----
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
H
P
N
V
Q
V
L
-
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
-
L
T
-
R
---
T
P
T
---
M
--
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
ES
P
E
W
A
--
S
-
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
R
S
M
V
E
A
-------
67
PsiBlast_CBE
55.40
40%
-107
- C2 -
2IXF
4
TAP1_RAT
C:
[12-255]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-
M
K
-----
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
H
P
N
V
Q
V
L
-
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
-
L
T
-
R
---
T
P
T
---
M
--
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
YES
P
E
W
A
--
S
-
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
R
S
M
V
E
A
L
------
71
PsiBlast_CBE
55.06
40%
-104
- C2 -
2IXE
4
TAP1_RAT
A:
[12-255]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-
M
K
-----
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
H
P
N
V
Q
V
L
-
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
-
L
T
-
R
---
T
P
T
---
M
--
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
YES
P
E
W
A
--
S
-
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
R
S
M
V
E
A
-------
66
PsiBlast_CBE
53.03
40%
-108
- C2 -
2IXF
4
D:
[12-255]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-
M
K
-----
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
H
P
N
V
Q
V
L
-
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
--
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
-
L
T
-
R
---
T
P
T
---
M
--
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
YES
P
E
W
A
--
S
-
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
R
S
M
V
E
A
-------
57
PsiBlast_CBE
51.18
43%
-105
- C2 -
1MV5
3
LMRA_LACLA
C:
[7-242]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
F
A
Y
-
D
D
S
E
Q
--
I
L
-
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
L
E
G
-
D
---
Y
-
T
---
D
--
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
---
D
S
L
M
--
K
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
P
L
Y
A
K
Y
V
S
E
Q
L
T
V
G
--
59
PsiBlast_CBE
48.87
43%
-100
- C2 -
1MV5
3
LMRA_LACLA
A:
[7-242]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
F
A
Y
-
D
D
S
E
Q
--
I
L
-
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
L
E
G
-
D
---
Y
-
T
---
D
--
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
---
D
S
L
M
--
K
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
P
L
Y
A
K
Y
V
S
E
Q
L
T
V
G
--
58
PsiBlast_CBE
47.96
43%
-98
- C2 -
1MV5
2
LMRA_LACLA
B:
[7-242]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
F
A
Y
-
D
D
S
E
Q
--
I
L
-
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
L
E
G
-
D
---
Y
-
T
---
D
--
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
---
D
S
L
M
--
K
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
P
L
Y
A
K
Y
V
S
E
Q
L
T
V
G
--
56
PsiBlast_CBE
42.49
43%
-98
- C2 -
1MV5
3
D:
[7-241]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
F
A
Y
-
D
D
S
E
Q
--
I
L
-
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
L
E
G
-
D
---
Y
-
T
---
D
--
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
---
D
S
L
M
--
K
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
P
L
Y
A
K
Y
V
S
E
Q
L
T
V
---