@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA1125: (2016-01-26 )
MRAVVELLAGARRLVIFTGAGVSAESGIPTFRDALGGLWARYDPAALATPAAFADDPALVWGWYEWRRLKVLGVQPNPAHRAIAALSGRIANTRLVTQNVDDLHERAGSRDVLHLHGSLHAPRCATCAAAYRDALPDSVEPEEGRRIEPPRCPACGGQVRPGVVWFGEALPEAALREAFAAACECDLLLSVGTSGVVQPAARIPGLALEHGASVVHVNPQPVRTRHPREHCLVGPAGEVLPELLRRAFPG
Atome Classification :
(50 SA)
----------------------------------------------------------------------------------.........10........20........30........40.--------.......50........60.......--.70--........80.......----.-90----.----.......100......--.110.......120.....---.---.130..----..---------.--...140---------......-----..-.-150--.--.--....-----.160.......170.......180.......190.......200.......210.......220..-------.....230.......240.......250--------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------
M
R
A
V
V
E
L
L
AGA
R
R
L
V
I
F
TGAGVSAESGI
P
T
F
R
D
A
L
G
G
L
W
ARY--------D
P
A
ALATPAAFADDP
A
L
V
W
G
W
Y
E
W
R
R
--
L
K
V
--
L
GVQPN
P
A
H
R
A
I
A
A
L
SG----R-IA----N----
T
R
L
V
TQ
N
V
D
D
L
H
E
RAG--SR
D
V
L
H
LHGSLHA
P
R
C
A
T
C
---
A
---
A
A
Y
-
R
D----AL---------P--DSVE-----------PEEGRR-----IE-P-PRC--P--A--CGGQ-----VRP
G
V
V
W
F
G
EAL
P
E
A
A
L
R
E
A
F
A
A
ACE
C
D
L
L
L
SVGTSGVV
Q
P
A
A
RIPGL
A
L
EHG
A
S
V
V
H
VNPQPVRT-------RHPREHCLVG
P
A
G
E
V
L
P
E
L
L
R
R
AFPG----------------------------------
32
PsiBlast_CBE
92.74
41%
-116
- C3 -
3RIG
3
SIR5_HUMAN
B:
[16-272]
---------------------------------------------------------------------------------------
K
F
F
A
K
A
K
H
I
V
I
I
S
G
A
-------------
A
-
G
G
Y
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
E
T
----
R
-
L
G
----
K
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
V
V
A
---
E
N
Y
-
K
S
PICP
A
L
---------
S
--
G
K
G
A
-----------
P
E
P
G
T
Q
DASIP
V
E
-
K
L
P
R
C
--
E
EA
G
--
C
G
G
L
-----
L
R
P
H
V
V
W
F
G
E
N
L
D
P
A
I
L
E
E
V
D
R
E
L
A
H
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
T
E
T
T
P
A
-------
T
N
R
F
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
A
---------------------------------------
1
PsiBlast_PDB
92.74
48%
-94
- C3 -
1M2G
2
NPD1_ARCFU
A:
[5-238]
-------------------------------------------------------------------------------------
L
L
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
-
D
G
L
W
N
R
Y
--------
R
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
--
E
K
V
--
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
E
R
----
L
-
G
V
----
L
----
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
--
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
---
N
---------------------------
N
S
F
E
-----------
V
E
S
A
P
K
-----
I
P
-
P
L
P
K
C
--
D
--
K
--
C
G
S
L
-----
L
R
P
G
V
V
W
F
G
E
M
L
P
P
D
V
L
D
R
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
P
D
E
T
P
L
-------
T
P
I
A
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
K
A
----------------------------------
94
Fugue
92.44
46%
-105
- C3 -
1ICI
2
NPD1_ARCFU
A:
[1-256]
---------------------------------------------------------------------GSHH
H
H
H
H
G
SHMD-
E
K
L
L
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
----
G
K
D
G
L
W
NRY-----
R
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
--
E
K
V
--
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
E
R
----
L
-
G
V
----
L
----
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
SR--
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
--------
C
N
N
-
S
F
----
E
V
---------
E
--
S
A
P
------------
K
I
P
---------
P
-
L
-
P
K
C
--
D
--
K
--
C
G
S
L
-----
L
R
P
G
V
V
W
F
G
E
M
L
P
P
D
V
L
D
R
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
P
D
E
---TPLTPIA----
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
--
K
A
L
S------------------------------
34
PsiBlast_CBE
92.30
41%
-104
- C3 -
4G1C
3
SIR5_HUMAN
B:
[10-266]
---------------------------------------------------------------------------------------
K
F
F
A
K
A
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
-
G
G
Y
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
E
T
----
R
-
L
G
----
K
QGRR
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
GVV
A
---
E
N
Y
-
K
S
PICP
A
L
---------
S
--
G
K
G
A
-----------
P
E
P
G
T
Q
DASIP
V
E
-
K
L
P
R
C
--
E
EA
G
--
C
G
G
L
-----
L
R
P
H
V
V
W
F
G
E
N
L
D
P
A
I
L
E
E
V
D
R
E
L
A
H
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
T
E
T
T
P
A
-------
T
N
R
F
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
A
---------------------------------------
3
PsiBlast_PDB
92.19
48%
-97
- C3 -
4TWI
2
NPD1_ARCFU
A:
[5-238]
-------------------------------------------------------------------------------------
L
L
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
-
D
G
L
W
N
R
Y
--------
R
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
--
E
K
V
--
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
E
R
----
L
-
G
V
----
L
----
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
--
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
---
N
---------------------------
N
S
F
E
-----------
V
E
S
A
P
K
-----
I
P
-
P
L
P
K
C
--
D
--
K
--
C
G
S
L
-----
L
R
P
G
V
V
W
F
G
E
M
L
P
P
D
V
L
D
R
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
P
D
E
T
P
L
-------
T
P
I
A
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
K
A
----------------------------------
11
PsiBlast_PDB
92.04
41%
-108
- C3 -
3RIG
3
SIR5_HUMAN
A:
[16-272]
---------------------------------------------------------------------------------------
K
F
F
A
K
A
K
H
I
V
I
I
S
G
A
G
V
-------------
G
G
Y
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
E
T
----
R
-
L
G
----
K
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
V
V
A
---
E
N
Y
-
K
S
PICP
A
L
---------
S
--
G
K
G
A
-----------
P
E
P
G
T
Q
DASIP
V
E
-
K
L
P
R
C
--
E
EA
G
--
C
G
G
L
-----
L
R
P
H
V
V
W
F
G
E
N
L
D
P
A
I
L
E
E
V
D
R
E
L
A
H
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
T
E
T
T
P
A
-------
T
N
R
F
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
A
---------------------------------------
93
Fugue
91.95
47%
-97
- C3 -
1ICI
2
NPD1_ARCFU
A:
[1-256]
----------------------------------------------------------------------GSHH
H
H
H
H
G
SHM
D
E
K
L
L
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
-
D
G
L
W
N
R
Y
--------
R
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
--
E
K
V
--
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
E
R
----
L
-
G
V
----
L
----
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
--
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
---
N
---
N
S
F
-
E
V
----
E
S
---------
A
--
P
K
I
P
-----------
P
-------------
L
-
P
K
C
--
D
--
K
--
C
G
S
L
-----
L
R
P
G
V
V
W
F
G
E
M
L
P
P
D
V
L
D
R
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
P
D
E
T
P
L
-------
T
P
I
A
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
K
A
L
S--------------------------------
5
PsiBlast_PDB
91.77
48%
-93
- C3 -
1M2J
2
NPD1_ARCFU
A:
[5-238]
-------------------------------------------------------------------------------------
L
L
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
-
D
G
L
W
N
R
Y
--------
R
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
--
E
K
V
--
F
N
A
Q
P
N
K
A
N
Q
A
F
A
E
L
E
R
----
L
-
G
V
----
L
----
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
--
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
---
N
---------------------------
N
S
F
E
-----------
V
E
S
A
P
K
-----
I
P
-
P
L
P
K
C
--
D
--
K
--
C
G
S
L
-----
L
R
P
G
V
V
W
F
G
E
M
L
P
P
D
V
L
D
R
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
P
D
E
T
P
L
-------
T
P
I
A
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
K
A
----------------------------------
12
PsiBlast_PDB
91.73
41%
-102
- C3 -
3RIY
3
SIR5_HUMAN
A:
[16-272]
---------------------------------------------------------------------------------------
K
F
F
A
K
A
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
-
G
G
Y
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
E
T
----
R
-
L
G
----
K
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
V
V
A
---
E
N
Y
-
K
S
PICP
A
L
---------
S
--
G
K
G
A
-----------
P
E
P
G
T
Q
DASIP
V
E
-
K
L
P
R
C
--
E
EA
G
--
C
G
G
L
-----
L
R
P
H
V
V
W
F
G
E
N
L
D
P
A
I
L
E
E
V
D
R
E
L
A
H
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
T
E
T
T
P
A
-------
T
N
R
F
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
A
---------------------------------------
33
PsiBlast_CBE
91.55
41%
-110
- C3 -
2NYR
2
SIR5_HUMAN
B:
[14-270]
---------------------------------------------------------------------------------------
K
F
F
A
K
A
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
-
G
G
Y
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
E
T
----
R
-
L
G
----
K
QGRR
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
GVV
A
---
E
N
Y
-
K
S
PICP
A
L
---------
S
--
G
K
G
A
-----------
P
E
P
G
T
Q
DASIP
V
E
-
K
L
P
R
C
--
E
EA
G
--
C
G
G
L
-----
L
R
P
H
V
V
W
F
G
E
N
L
D
P
A
I
L
E
E
V
D
R
E
L
A
H
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
T
----------------
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
A
---------------------------------------
4
PsiBlast_PDB
91.39
48%
-93
- C3 -
1M2H
2
NPD1_ARCFU
A:
[5-238]
-------------------------------------------------------------------------------------
L
L
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
A
A
E
S
G
I
P
T
F
R
G
K
-
D
G
L
W
N
R
Y
--------
R
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
--
E
K
V
--
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
E
R
----
L
-
G
V
----
L
----
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
--
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
---
N
---------------------------
N
S
F
E
-----------
V
E
S
A
P
K
-----
I
P
-
P
L
P
K
C
--
D
--
K
--
C
G
S
L
-----
L
R
P
G
V
V
W
F
G
E
M
L
P
P
D
V
L
D
R
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
P
D
E
T
P
L
-------
T
P
I
A
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
K
A
----------------------------------
18
PsiBlast_PDB
91.27
41%
-105
- C3 -
2B4Y
3
SIR5_HUMAN
A:
[14-270]
---------------------------------------------------------------------------------------
K
F
F
A
K
A
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
--------
G
Y
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
E
T
----
R
-
L
G
----
K
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
V
V
A
---
E
N
Y
-
K
S
PICP
A
L
---------
S
--
G
K
G
A
-----------
P
E
P
G
T
Q
DASIP
V
E
-
K
L
P
R
C
--
E
EA
G
--
C
G
G
L
-----
L
R
P
H
V
V
W
F
G
E
N
L
D
P
A
I
L
E
E
V
D
R
E
L
A
H
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
T
E
T
T
P
A
-------
T
N
R
F
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
A
---------------------------------------
31
PsiBlast_CBE
91.09
41%
-100
- C3 -
3RIY
3
SIR5_HUMAN
B:
[16-272]
---------------------------------------------------------------------------------------
K
F
F
A
K
A
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
-
G
G
Y
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
E
T
----
R
-
L
G
----
K
QGRR
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
GVV
A
---
E
N
Y
-
K
S
PICP
A
L
---------
S
--
G
K
G
A
-----------
P
E
P
G
T
Q
DASIP
V
E
-
K
L
P
R
C
--
E
EA
G
--
C
G
G
L
-----
L
R
P
H
V
V
W
F
G
E
N
L
D
P
A
I
L
E
E
V
D
R
E
L
A
H
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
T
E
T
T
P
A
-------
T
N
R
F
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
A
---------------------------------------
30
PsiBlast_CBE
91.09
41%
-104
- C3 -
4F56
3
SIR5_HUMAN
B:
[16-272]
---------------------------------------------------------------------------------------
K
F
F
A
K
A
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
-
G
G
Y
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
E
T
----
R
-
L
G
----
K
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
V
V
A
---
E
N
Y
-
K
S
PICP
A
L
---------
S
--
G
K
G
A
-----------
P
E
P
G
T
Q
DASIP
V
E
-
K
L
P
R
C
--
E
EA
G
--
C
G
G
L
-----
L
R
P
H
V
V
W
F
G
E
N
L
D
P
A
I
L
E
E
V
D
R
E
L
A
H
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
T
E
T
T
P
A
-------
T
N
R
F
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
A
---------------------------------------
15
PsiBlast_PDB
91.07
41%
-110
- C3 -
2NYR
2
SIR5_HUMAN
A:
[14-270]
---------------------------------------------------------------------------------------
K
F
F
A
K
A
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
-
G
G
Y
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
E
T
----
R
-
L
G
----
K
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
V
V
A
---
E
N
Y
-
K
S
PICP
A
L
---------
S
--
G
K
G
A
-----------
P
E
P
G
T
Q
DASIP
V
E
-
K
L
P
R
C
--
E
EA
G
--
C
G
G
L
-----
L
R
P
H
V
V
W
F
G
E
N
L
D
P
A
I
L
E
E
V
D
R
E
L
A
H
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
T
E
---------------
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
A
---------------------------------------
14
PsiBlast_PDB
91.04
41%
-101
- C3 -
4F56
3
SIR5_HUMAN
A:
[16-272]
---------------------------------------------------------------------------------------
K
F
F
A
K
A
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
-
G
G
Y
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
E
T
----
R
-
L
G
----
K
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
V
V
A
---
E
N
Y
-
K
S
PICP
A
L
---------
S
--
G
K
G
A
-----------
P
E
P
G
T
Q
DASIP
V
E
-
K
L
P
R
C
--
E
EA
G
--
C
G
G
L
-----
L
R
P
H
V
V
W
F
G
E
N
L
D
P
A
I
L
E
E
V
D
R
E
L
A
H
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
T
E
T
T
P
A
-------
T
N
R
F
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
A
---------------------------------------
21
PsiBlast_CBE
90.69
48%
-94
- C3 -
1ICI
2
NPD1_ARCFU
B:
[16-249]
-------------------------------------------------------------------------------------
L
L
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
-
D
G
L
W
N
R
Y
--------
R
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
--
E
K
V
--
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
E
R
----
L
-
G
V
----
L
----
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
--
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
---
N
---------------------------
N
S
F
E
-----------
V
E
S
A
P
K
-----
I
P
-
P
L
P
K
C
--
D
--
K
--
C
G
S
L
-----
L
R
P
G
V
V
W
F
G
E
M
L
P
P
D
V
L
D
R
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
P
D
E
T
P
L
-------
T
P
I
A
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
K
A
----------------------------------
16
PsiBlast_PDB
90.63
41%
-101
- C3 -
4G1C
4
SIR5_HUMAN
A:
[10-266]
---------------------------------------------------------------------------------------
K
F
F
A
K
A
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
-
G
G
Y
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
E
T
----
R
-
L
G
----
K
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
V
V
A
---
E
N
Y
-
K
S
PICP
A
L
---------
S
--
G
K
G
A
-----------
P
E
P
G
T
Q
DASIP
V
E
-
K
L
P
R
C
--
E
EA
G
--
C
G
G
L
-----
L
R
P
H
V
V
W
F
G
E
N
L
D
P
A
I
L
E
E
V
D
R
E
L
A
H
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
T
E
T
T
P
A
-------
T
N
R
F
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
A
---------------------------------------
13
PsiBlast_PDB
90.46
41%
-107
- C3 -
4F4U
2
SIR5_HUMAN
A:
[16-272]
---------------------------------------------------------------------------------------
K
F
F
A
K
A
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
-----
G
Y
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
E
T
----
R
-
L
G
----
K
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
V
V
A
---
E
N
Y
-
K
S
PICP
A
L
---------
S
--
G
K
G
A
-----------
P
E
P
G
T
Q
DASIP
V
E
-
K
L
P
R
C
--
E
EA
G
--
C
G
G
L
-----
L
R
P
H
V
V
W
F
G
E
N
L
D
P
A
I
L
E
E
V
D
R
E
L
A
H
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
T
E
T
T
P
A
-------
T
N
R
F
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
A
---------------------------------------
6
PsiBlast_PDB
90.46
48%
-92
- C3 -
1M2K
2
NPD1_ARCFU
A:
[5-238]
-------------------------------------------------------------------------------------
L
L
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
-
D
G
L
W
N
R
Y
--------
R
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
--
E
K
V
--
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
E
R
----
L
-
G
V
----
L
----
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
--
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
---
N
---------------------------
N
S
F
E
-----------
V
E
S
A
P
K
-----
I
P
-
P
L
P
K
C
--
D
--
K
--
C
G
S
L
-----
L
R
P
G
V
V
W
A
G
E
M
L
P
P
D
V
L
D
R
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
P
D
E
T
P
L
-------
T
P
I
A
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
K
A
----------------------------------
22
PsiBlast_CBE
90.25
47%
-95
- C3 -
1M2N
2
NPD1_ARCFU
B:
[5-238]
-------------------------------------------------------------------------------------
L
L
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
-
D
G
L
W
N
R
Y
--------
R
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
--
E
K
V
--
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
E
R
----
L
-
G
V
----
L
----
K
C
L
I
T
Q
N
V
D
G
L
H
E
R
A
G
--
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
---
N
---------------------------
N
S
F
E
-----------
V
E
S
A
P
K
-----
I
P
-
P
L
P
K
C
--
D
--
K
--
C
G
S
L
-----
L
R
P
G
V
V
W
A
G
E
M
L
P
P
D
V
L
D
A
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
P
D
E
T
P
L
-------
T
P
I
A
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
K
A
----------------------------------
2
PsiBlast_PDB
90.13
48%
-94
- C3 -
1ICI
2
NPD1_ARCFU
A:
[16-249]
-------------------------------------------------------------------------------------
L
L
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
-
D
G
L
W
N
R
Y
--------
R
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
--
E
K
V
--
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
E
R
----
L
-
G
V
----
L
----
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
--
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
---
N
---------------------------
N
S
F
E
-----------
V
E
S
A
P
K
-----
I
P
-
P
L
P
K
C
--
D
--
K
--
C
G
S
L
-----
L
R
P
G
V
V
W
F
G
E
M
L
P
P
D
V
L
D
R
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
P
D
E
T
P
L
-------
T
P
I
A
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
K
A
----------------------------------
37
PsiBlast_CBE
89.89
39%
-108
- C3 -
4UUB
5
SIR5_DANRE
A:
[13-274]
----------------------------------------------------------------------------------
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
-
G
G
F
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
----
R
-
L
G
Q
Q
G
R
S
----
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
---
G
E
V
K
A
N
H
-
K
S
----
P
I
CPALDGKGA
P
--
D
P
N
T
-----------
K
E
A
R
I
P
-----
V
E
L
L
-
P
R
C
ER
K
--
S
--
C
N
G
L
-----
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
P
A
-------
T
Q
--
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
102
HHSearch
89.57
47%
-98
* C3 *
1M2K
2
NPD1_ARCFU
A:
[3-242]
-----------------------------------------------------------------------------------
E
K
L
L
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
-
D
G
L
W
N
R
Y
--------
R
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
--
E
K
V
--
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
E
R
----
L
-
G
V
----
L
----
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
--
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
---
N
---
N
S
F
-
E
V
----
E
S
---------
A
--------------------
P
K
I
-----
P
P
-
L
-
P
K
C
--
D
--
K
--
C
G
S
L
-----
L
R
P
G
V
V
W
A
G
E
M
L
P
P
D
V
L
D
R
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
P
D
E
T
P
L
-------
T
P
I
A
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
K
A
----------------------------------
49
PsiBlast_CBE
89.35
39%
-105
- C3 -
4UTV
4
SIR5_DANRE
A:
[13-274]
----------------------------------------------------------------------------------
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
-
G
G
F
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
----
R
-
L
G
Q
Q
G
R
S
----
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
---
G
E
V
K
A
N
H
-
K
S
----
P
I
CPALDGKGA
P
--
D
P
N
T
-----------
K
E
A
R
I
P
-----
V
E
L
L
-
P
R
C
ER
K
--
S
--
C
N
G
L
-----
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
--------------
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
20
PsiBlast_PDB
89.34
39%
-108
- C3 -
4UTR
6
SIR5_DANRE
A:
[13-274]
----------------------------------------------------------------------------------
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
-
G
G
F
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
----
R
-
L
G
Q
Q
G
R
S
----
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
---
G
E
V
K
A
N
H
-
K
S
----
P
I
CPALDGKGA
P
--
D
P
N
T
-----------
K
E
A
R
I
P
-----
V
E
L
L
-
P
R
C
ER
K
--
S
--
C
N
G
L
-----
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
P
A
-------
T
Q
--
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
48
PsiBlast_CBE
89.28
39%
-104
- C3 -
4UTV
4
SIR5_DANRE
B:
[13-274]
----------------------------------------------------------------------------------
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
-
G
G
F
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
----
R
-
L
G
Q
Q
G
R
S
----
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
---
G
E
V
K
A
N
H
-
K
S
----
P
I
CPALDGKGA
P
--
D
P
N
T
-----------
K
E
A
R
I
P
-----
V
E
L
L
-
P
R
C
ER
K
--
S
--
C
N
G
L
-----
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
--------------
F
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
51
PsiBlast_CBE
89.25
39%
-102
- C3 -
4UTN
4
SIR5_DANRE
B:
[13-274]
----------------------------------------------------------------------------------
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
-
G
G
F
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
----
R
-
L
G
Q
Q
G
R
S
----
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
---
G
E
V
K
A
N
H
-
K
S
----
P
I
CPALDGKGA
P
--
D
P
N
T
-----------
K
E
A
R
I
P
-----
V
E
L
L
-
P
R
C
ER
K
--
S
--
C
N
G
L
-----
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
P
A
-------
T
Q
R
F
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
41
PsiBlast_CBE
88.98
39%
-104
- C3 -
4UU8
4
SIR5_DANRE
A:
[13-274]
----------------------------------------------------------------------------------
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
-
G
G
F
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
----
R
-
L
G
Q
Q
G
R
S
----
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
---
G
E
V
K
A
N
H
-
K
S
----
P
I
CPALDGKGA
P
--
D
P
N
T
-----------
K
E
A
R
I
P
-----
V
E
L
L
-
P
R
C
ER
K
--
S
--
C
N
G
L
-----
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
P
A
-------
T
Q
--
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
19
PsiBlast_PDB
88.98
39%
-105
- C3 -
4UTN
3
SIR5_DANRE
A:
[13-274]
----------------------------------------------------------------------------------
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
-
G
G
F
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
----
R
-
L
G
Q
Q
G
R
S
----
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
---
G
E
V
K
A
N
H
-
K
S
----
P
I
CPALDGKGA
P
--
D
P
N
T
-----------
K
E
A
R
I
P
-----
V
E
L
L
-
P
R
C
ER
K
--
S
--
C
N
G
L
-----
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
P
A
-------
T
---
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
40
PsiBlast_CBE
88.84
39%
-103
- C3 -
4UU8
5
SIR5_DANRE
B:
[13-274]
----------------------------------------------------------------------------------
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
-
G
G
F
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
----
R
-
L
G
Q
Q
G
R
S
----
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
---
G
E
V
K
A
N
H
-
K
S
----
P
I
CPALDGKGA
P
--
D
P
N
T
-----------
K
E
A
R
I
P
-----
V
E
L
L
-
P
R
C
ER
K
--
S
--
C
N
G
L
-----
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
P
A
-------
T
Q
R
F
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
43
PsiBlast_CBE
88.70
39%
-105
- C3 -
4UU7
7
SIR5_DANRE
A:
[13-274]
----------------------------------------------------------------------------------
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
-
G
G
F
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
----
R
-
L
G
Q
Q
G
R
S
----
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
---
G
E
V
K
A
N
H
-
K
S
----
P
I
CPALDGKGA
P
--
D
P
N
T
-----------
K
E
A
R
I
P
-----
V
E
L
L
-
P
R
C
ER
K
--
S
--
C
N
G
L
-----
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
P
A
-------
T
Q
--
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
45
PsiBlast_CBE
88.59
39%
-104
- C3 -
4UTZ
4
SIR5_DANRE
A:
[13-274]
----------------------------------------------------------------------------------
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
-
G
G
F
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
----
R
-
L
G
Q
Q
G
R
S
----
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
---
G
E
V
K
A
N
H
-
K
S
----
P
I
CPALDGKGA
P
--
D
P
N
T
-----------
K
E
A
R
I
P
-----
V
E
L
L
-
P
R
C
ER
K
--
S
--
C
N
G
L
-----
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
P
A
-------
T
Q
--
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
44
PsiBlast_CBE
88.58
39%
-101
- C3 -
4UTZ
5
SIR5_DANRE
B:
[13-274]
----------------------------------------------------------------------------------
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
-
G
G
F
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
----
R
-
L
G
Q
Q
G
R
S
----
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
---
G
E
V
K
A
N
H
-
K
S
----
P
I
CPALDGKGA
P
--
D
P
N
T
-----------
K
E
A
R
I
P
-----
V
E
L
L
-
P
R
C
ER
K
--
S
--
C
N
G
L
-----
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
------------
F
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
47
PsiBlast_CBE
88.41
39%
-105
- C3 -
4UTX
6
SIR5_DANRE
A:
[13-274]
----------------------------------------------------------------------------------
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
-
G
G
F
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
----
R
-
L
G
Q
Q
G
R
S
----
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
---
G
E
V
K
A
N
H
-
K
S
----
P
I
CPALDGKGA
P
--
D
P
N
T
-----------
K
E
A
R
I
P
-----
V
E
L
L
-
P
R
C
ER
K
--
S
--
C
N
G
L
-----
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
P
A
-------
T
Q
--
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
46
PsiBlast_CBE
88.33
39%
-99
- C3 -
4UTX
5
SIR5_DANRE
B:
[13-274]
----------------------------------------------------------------------------------
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
-
G
G
F
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
----
R
-
L
G
Q
Q
G
R
S
----
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
---
G
E
V
K
A
N
H
-
K
S
----
P
I
CPALDGKGA
P
--
D
P
N
T
-----------
K
E
A
R
I
P
-----
V
E
L
L
-
P
R
C
ER
K
--
S
--
C
N
G
L
-----
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
-------------
F
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
25
PsiBlast_CBE
88.21
43%
-100
- C3 -
1YC2
7
NPD2_ARCFU
C:
[5-243]
----------------------------------------------------------------------------------
I
R
K
A
A
E
I
L
A
K
S
K
H
A
V
V
F
T
G
A
G
I
S
A
E
S
G
I
P
T
F
R
G
E
-
D
G
L
W
R
K
Y
--------
D
P
E
E
V
A
S
I
S
G
F
K
R
N
P
R
A
F
W
E
F
S
M
E
M
K
--
D
K
L
--
F
A
-
E
P
N
P
A
H
Y
A
I
A
E
L
E
R
----
M
-
G
I
----
V
----
K
A
V
I
T
Q
N
I
D
M
L
H
Q
R
A
G
--
S
R
R
V
L
E
L
H
G
S
M
D
K
L
D
C
L
D
C
---
H
---
E
T
Y
---------------------
D
W
S
E
F----------
V
E
D
F
N
K
-----
G
E
-
I
-
P
R
C
--
R
--
K
--
C
G
S
Y
Y----
V
K
P
R
V
V
L
F
G
E
P
L
P
Q
R
T
L
F
E
A
I
E
E
A
K
H
C
D
A
F
M
V
V
G
S
S
L
V
V
Y
P
A
A
E
L
P
Y
I
A
K
K
A
G
A
K
M
I
I
V
N
A
E
P
T
M
A
-------
D
P
I
F
D
V
K
I
I
G
K
A
G
E
V
L
P
K
I
V
E
E
V
K
R
L
----------------------------------
39
PsiBlast_CBE
88.19
39%
-103
- C3 -
4UUA
5
SIR5_DANRE
A:
[13-274]
----------------------------------------------------------------------------------
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
-
G
G
F
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
----
R
-
L
G
Q
Q
G
R
S
----
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
---
G
E
V
K
A
N
H
-
K
S
----
P
I
CPALDGKGA
P
--
D
P
N
T
-----------
K
E
A
R
I
P
-----
V
E
L
L
-
P
R
C
ER
K
--
S
--
C
N
G
L
-----
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
P
A
-------
T
Q
--
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
42
PsiBlast_CBE
88.11
39%
-98
- C3 -
4UU7
5
SIR5_DANRE
B:
[13-274]
----------------------------------------------------------------------------------
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
-
G
G
F
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
----
R
-
L
G
Q
Q
G
R
S
----
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
---
G
E
V
K
A
N
H
-
K
S
----
P
I
CPALDGKGA
P
--
D
P
N
T
-----------
K
E
A
R
I
P
-----
V
E
L
L
-
P
R
C
ER
K
--
S
--
C
N
G
L
-----
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
P
A
-------
T
Q
R
F
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
38
PsiBlast_CBE
88.04
39%
-97
- C3 -
4UUA
5
SIR5_DANRE
B:
[13-274]
----------------------------------------------------------------------------------
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
-
G
G
F
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
----
R
-
L
G
Q
Q
G
R
S
----
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
---
G
E
V
K
A
N
H
-
K
S
----
P
I
CPALDGKGA
P
--
D
P
N
T
-----------
K
E
A
R
I
P
-----
V
E
L
L
-
P
R
C
ER
K
--
S
--
C
N
G
L
-----
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
P
A
-------
T
Q
R
F
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
17
PsiBlast_PDB
87.86
41%
-97
- C3 -
4HDA
2
SIR5_HUMAN
A:
[18-274]
---------------------------------------------------------------------------------------
K
F
F
A
K
A
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
-
G
G
Y
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
E
T
----
R
-
L
G
----
K
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
V
V
A
---
E
N
Y
-
K
S
PICP
A
L
---------
S
--
G
K
G
A
-----------
P
E
P
G
T
Q
DASIP
V
E
-
K
L
P
R
C
--
E
EA
G
--
C
G
G
L
-----
L
R
P
H
V
V
W
F
G
E
N
L
D
P
A
I
L
E
E
V
D
R
E
L
A
H
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
T
E
T
T
P
A
-------
T
N
R
F
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
----------------------------------------
36
PsiBlast_CBE
87.79
39%
-100
- C3 -
4UUB
5
SIR5_DANRE
B:
[13-274]
----------------------------------------------------------------------------------
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
-
G
G
F
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
----
R
-
L
G
Q
Q
G
R
S
----
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
---
G
E
V
K
A
N
H
-
K
S
----
P
I
CPALDGKGA
P
--
D
P
N
T
-----------
K
E
A
R
I
P
-----
V
E
L
L
-
P
R
C
ER
K
--
S
--
C
N
G
L
-----
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
K
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
P
A
----------
F
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
35
PsiBlast_CBE
87.72
41%
-97
- C3 -
4HDA
3
SIR5_HUMAN
B:
[18-274]
---------------------------------------------------------------------------------------
K
F
F
A
K
A
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
-
G
G
Y
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
E
T
----
R
-
L
G
----
K
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
V
V
A
---
E
N
Y
-
K
S
PICP
A
L
---------
S
--
G
K
G
A
-----------
P
E
P
G
T
Q
DASIP
V
E
-
K
L
P
R
C
--
E
EA
G
--
C
G
G
L
-----
L
R
P
H
V
V
W
F
G
E
N
L
D
P
A
I
L
E
E
V
D
R
E
L
A
H
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
T
E
T
T
P
A
-------
T
N
R
F
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
A
---------------------------------------
104
HHSearch
87.66
41%
-94
- C3 -
3RIY
3
SIR5_HUMAN
A:
[11-273]
----------------------------------------------------------------------------------
M
A
D
F
R
K
F
F
A
K
A
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
-
G
G
Y
W
R
K
W
--------
Q
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
--
E
V
M
--
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
E
T
R
L
G
K
Q
-
G
R
----
R
----
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
---
G
---
V
V
A
-
E
N
----
Y
K
---------
S
PI
C
P
A
L
SGKGAPEPGTQ
D
A
S
I
P
V
-----
E
K
-
L
-
P
R
C
--
E
--
E
AG
C
G
G
L
-----
L
R
P
H
V
V
W
F
G
E
N
L
D
P
A
I
L
E
E
V
D
R
E
L
A
H
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
T
E
T
T
P
A
-------
T
N
R
F
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
A
---------------------------------------
26
PsiBlast_CBE
87.32
43%
-97
- C3 -
1YC2
8
NPD2_ARCFU
B:
[5-243]
----------------------------------------------------------------------------------
I
R
K
A
A
E
I
L
A
K
S
K
H
A
V
V
F
T
G
A
G
I
S
A
E
S
G
I
P
T
F
R
G
E
-
D
G
L
W
R
K
Y
--------
D
P
E
E
V
A
S
I
S
G
F
K
R
N
P
R
A
F
W
E
F
S
M
E
M
K
--
D
K
L
--
F
A
-
E
P
N
P
A
H
Y
A
I
A
E
L
E
R
----
M
-
G
I
----
V
----
K
A
V
I
T
Q
N
I
D
M
L
H
Q
R
A
G
--
S
R
R
V
L
E
L
H
G
S
M
D
K
L
D
C
L
D
C
---
H
---
E
T
Y
---------------------
D
W
S
E
F----------
V
E
D
F
N
K
-----
G
E
-
I
-
P
R
C
--
R
--
K
--
C
G
S
Y
Y----
V
K
P
R
V
V
L
F
G
E
P
L
P
Q
R
T
L
F
E
A
I
E
E
A
K
H
C
D
A
F
M
V
V
G
S
S
L
V
V
Y
P
A
A
E
L
P
Y
I
A
K
K
A
G
A
K
M
I
I
V
N
A
E
P
T
M
A
-------
D
P
I
F
D
V
K
I
I
G
K
A
G
E
V
L
P
K
I
V
E
E
V
K
R
L
----------------------------------
7
PsiBlast_PDB
87.17
47%
-92
- C3 -
1M2N
2
NPD1_ARCFU
A:
[5-238]
-------------------------------------------------------------------------------------
L
L
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
-
D
G
L
W
N
R
Y
--------
R
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
--
E
K
V
--
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
E
R
----
L
-
G
V
----
L
----
K
C
L
I
T
Q
N
V
D
G
L
H
E
R
A
G
--
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
---
N
---------------------------
N
S
F
E
-----------
V
E
S
A
P
K
-----
I
P
-
P
L
P
K
C
--
D
--
K
--
C
G
S
L
-----
L
R
P
G
V
V
W
A
G
E
M
L
P
P
D
V
L
D
A
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
P
D
E
T
P
L
-------
T
P
I
A
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
K
A
----------------------------------
52
PsiBlast_CBE
85.71
40%
-105
- C3 -
1S5P
2
NPD_ECOLI
A:
[3-233]
----------------------------------------------------------------------------------------------
R
V
L
V
L
T
G
A
G
I
S
A
E
S
G
I
R
T
F
R
-
A
A
D
G
L
W
E
E
H
--------
R
V
E
D
V
A
T
P
E
G
F
D
R
D
P
E
L
V
Q
A
F
Y
N
A
R
R
R
Q
L
Q
Q
--
P
E
I
Q
P
N
A
A
H
L
A
L
A
K
L
Q
D
----
A
-
L
G
----
D
R---
F
L
L
V
T
Q
N
I
D
N
L
H
E
R
A
G
--
N
T
N
V
I
H
M
H
G
E
L
L
K
V
R
C
S
Q
S
---
G
---
Q
V
L
--
D
----
W
T
---------
G
--
D
-
V
T
-----------
P
E
D
--------------
K
C
-----------
P
-----
L
R
P
H
V
V
W
F
G
E
-
M
P
-
L
G
M
D
E
I
Y
M
A
L
S
M
A
D
I
F
I
A
I
G
T
S
G
H
V
Y
P
A
A
G
F
V
H
E
A
K
L
H
G
A
H
T
V
E
L
N
L
E
P
S
Q
----------
E
F
A
E
K
Y
Y
G
P
A
S
Q
V
V
P
E
F
V
E
K
L
L
K
G
----------------------------------
106
HHSearch
82.19
40%
-93
- C3 -
1S5P
2
NPD_ECOLI
A:
[1-232]
--------------------------------------------------------------------------------------------
K
P
R
V
L
V
L
T
G
A
G
I
S
A
E
S
G
I
R
T
F
R
A
A
-
D
G
L
W
E
E
H
--------
R
V
E
D
V
A
T
P
E
G
F
D
R
D
P
E
L
V
Q
A
F
Y
N
A
R
R
--
R
Q
L
Q
Q
P
E
I
Q
P
N
A
A
H
L
A
L
A
K
L
Q
D
----
A
L
G
D
----
R
----
F
L
L
V
T
Q
N
I
D
N
L
H
E
R
A
G
--
N
T
N
V
I
H
M
H
G
E
L
L
K
V
R
C
S
Q
S
---
G
---
Q
V
L
-
D
W
----
T
G
---------
D
----------------------
V
-----
T
P
-
E
-
D
K
C
-----------
P
-----
L
R
P
H
V
V
W
F
G
E
M
P
L
G
--
M
D
E
I
Y
M
A
L
S
M
A
D
I
F
I
A
I
G
T
S
G
H
V
Y
P
A
A
G
F
V
H
E
A
K
L
H
G
A
H
T
V
E
L
N
L
E
P
S
Q
----------
E
F
A
E
K
Y
Y
G
P
A
S
Q
V
V
P
E
F
V
E
K
L
L
K
G
----------------------------------
97
Fugue
80.90
32%
-101
- C3 -
5BTR
6
?
A:
[4-390]
DNLLFGD
E
I
I
T
N
GSDWTP
R
P
R
I
G
P
Y
T
F
V
Q
Q
H
L
M
I
GTD
P
R
T
I
L
K
D
L
LPETIPPPELD
D
M
T
L
W
Q
I
V
I
N
I
L
S
E
P
P
K
R
K
KRKDINT
I
E
D
A
V
K
L
L
Q
E
S
K
K
I
I
V
L
T
G
A
G
V
S
V
S
S
G
I
P
D
F
R
S
R
-
D
G
I
Y
A
R
L
A
V
D
F
PDLP
D
P
Q
A
M
F
D
I
E
Y
F
R
K
D
P
R
P
F
F
K
F
A
--
K
E
--
I
Y
P
--
G
Q
F
Q
P
S
L
C
H
K
F
I
A
L
S
D
K
----
E
-
G
K
----
L
----
L
R
N
Y
T
Q
N
I
D
T
L
E
Q
V
A
G
--
I
Q
R
I
I
Q
C
H
G
S
F
A
T
A
S
C
L
I
C
---
K
---
Y
K
V
D
C
E
----
A
V
---------
R
--
G
D
I
F
-----------
N
Q
V
-----------
V
-
P
R
C
--
P
--
R
--
C
P
A
D
EPLAI
M
K
P
E
I
V
F
F
G
E
N
L
P
E
Q
F
H
R
A
M
K
Y
D
K
D
E
V
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
A
L
I
P
S
S
-
I
P
H
E
V
P
Q
I
L
I
N
R
E
P
L
P
H
-------
L
H
F
-
D
V
E
L
L
G
D
C
D
V
I
I
N
E
L
C
H
R
L
G
G
E
YAKLSSNP
V
K
L
S
E
ITE
Q
Y
L
F
L
P
P
N
R
Y
I
F
H
GAEVY
103
HHSearch
75.47
31%
-94
- C3 -
1YC5
3
NPD_THEMA
A:
[3-244]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
---------------------
Q
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
K
E
G
I
--
F
P
M
--
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
E
E
----
K
-
G
L
----
I
----
E
A
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
---
E
---
K
K
Y
-
T
V
----
E
D
---------
V
--
I
K
---------------
K
L
E
S
-----
S
D
-
V
-
P
L
C
--
D
--
D
--
C
N
S
L
-----
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
D
A
L
R
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
L
I
T
V
R
S
G
G
K
L
V
I
V
N
L
G
E
T
P
F
-------
D
D
I
A
T
L
K
Y
N
M
D
V
V
E
F
A
R
R
V
M
E
E
G
G
I
-----------------------------------