@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA1148: (2016-01-27 )
MHLTPHWIPLVASLGLLAGGSFASAAEEAFDLWNECAKACVLDLKDGVRSSRMSVDPAIADTNGQGVLHYSMVLEGGNDALKLAIDNALSITSDGLTIRLEGGVEPNKPVRYSYTRQARGSWSLNWLVPIGHEKPSNIKVFIHELNAGNQLSHMSPIYTIEMGDELLAKLARDATFFVRAHESNEMQPTLAISHAGVSVVMAQAQPRREKRWSEWASGKVLCLLDPLDGVYNYLAQQRCNLDDTWEGKIYRVLAGNPAKHDLDIKPTVISHRLHFPEGGSLAALTAHQACHLPLETFTRHRQPRGWEQLEQCGYPVQRLVALYLAARLSWNQVDQVIRNALASPGSGGDLGEAIREQPEQARLALTLAAAESERFVRQGTGNDEAGAASADVVSLTCPVAAGECAGPADSGDALLERNYPTGAEFLGDGGDISFSTRGTQNWTVERLLQAHRQLEERGYVFVGYHGTFLEAAQSIVFGGVRARSQDLDAIWRGFYIAGDPALAYGYAQDQEPDARGRIRNGALLRVYVPRSSLPGFYRTGLTLAAPEAAGEVERLIGHPLPLRLDAITGPEEEGGRLETILGWPLAERTVVIPSAIPTDPRNVGGDLDPSSIPDKEQAISALPDYASQPGKPPREDLK
Atome Classification :
(30 SA)
.........10........20........30........40.......-.50.-.......60----.........70........80.......--.90....----------------------.-...---------------100.......110......-.120.......130.......140.......150.......160......--.170--.......180.-......190.......200.......210.......220.......230.......240.......250....-.----..260....-----...270------.........280.......290.......300.......310.......320.......330.......340-...--...---..350-...-.....360.......370.......380---........390.......400.......410.......420.......430.......440.......450.......460.......470.......---480-.........490.......500.......510------....-------....520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MHLT
P
H
W
I
P
L
V
A
S
L
G
L
LAGGS
F
A
S
A
A
E
E
A
F
D
L
W
N
E
C
A
K
A
C
V
L
D
L
K
D
G
V
-RSSR-MSVDPAIA-----DTNG
Q
G
V
L
H
Y
S
M
V
L
EGGN
D
A
L
K
L
A
IDN
A
--
L
S
ITSD
G
----------------------
L
-
T
I
R
---------------
L
EGGVEPNK
P
V
R
Y
S
Y
T
RQA-RGSW
S
L
N
W
L
V
PIGHEKPS
N
I
K
V
F
I
H
ELNAGNQLSHMS
P
I
Y
T
I
EM
G
D
E
L
L
A
--
K
L
AR--D
A
T
F
F
V
R
AHES-NEMQ
P
T
L
A
I
SHA
G
V
S
V
V
M
AQAQP
R
R
E
K
R
W
S
E
WAS
G
K
V
L
C
L
LDP
L
D
G
V
Y
N
Y
L
A
Q
Q
RCNLDDTWE
G
K
I
Y
R
V
LAGN-P----AKHDLDIKP-----T
V
I
S
--------HRLHFPEGG
S
L
A
A
L
T
AH
Q
A
CHL
P
L
E
T
F
T
RHRQPR
G
W
E
Q
L
E
QCG
Y
P
V
Q
R
L
V
A
L
Y
L
A
A
RL
S
W
N
Q
V
D
Q
V
I
R
N
AL--ASP--GSG---G
D
L
G
--
E
A
I
-
R
EQ
P
E
QA
R
L
A
L
T
L
AAA
E
S
E
R
F
V
RQGTG----NDEAGAASA
D
V
V
S
L
TCPVAAGECAGPADSG
D
A
L
L
ERNYPT
G
A
E
FLGDGG
D
I
S
F
STRGTQN
W
T
V
E
R
L
L
Q
A
H
R
Q
L
E
ERG
Y
V
F
V
GYH
G
T
F
L
E
A
A
Q
S
I
V
F
GG---V---RARS
Q
D
L
D
A
I
W
R
G
F
Y
IAGDPA
L
A
YGYAQDQE-------PDAR-------GRIRN
G
A
L
L
R
V
YVPRSSLP
G
F
Y
RTG
L
T
LAAPEAA
G
E
V
E
R
L
IGHPL
P
L
R
L
DAITGPEEEGG
R
L
E
T
I
LGWPLAE
R
T
V
V
IPSAIPTDPRNVGGDLDPSSIP
D
K
E
Q
A
I
S
ALP
D
Y
ASQPGKPPREDLK
1
PsiBlast_PDB
97.27
99%
-99
- C8 -
1IKQ
4
TOXA_PSEAE
A:
[2-606]
--------------------------
E
E
A
F
D
L
W
N
E
C
A
K
A
C
V
L
D
L
K
D
G
V
-
R
S
S
R
-
M
S
V
D
P
A
I
A
-----
D
T
N
G
Q
G
V
L
H
Y
S
M
V
L
E
G
G
N
D
A
L
K
L
A
I
D
N
A
--
L
S
I
T
S
D
G
----------------------
L
-
T
I
R
---------------
L
E
G
G
V
E
P
N
K
P
V
R
Y
S
Y
T
R
Q
A
-
R
G
S
W
S
L
N
W
L
V
P
I
G
H
E
K
P
S
N
I
K
V
F
I
H
E
L
N
A
G
N
Q
L
S
H
M
S
P
I
Y
T
I
E
M
G
D
E
L
L
A
--
K
L
A
R
--
D
A
T
F
F
V
R
A
H
E
S
-
N
E
M
Q
P
T
L
A
I
S
H
A
G
V
S
V
V
M
A
Q
------
K
R
W
S
E
W
A
S
G
K
V
L
C
L
L
D
P
L
D
G
V
Y
N
Y
L
A
Q
Q
R
C
N
L
D
D
T
W
E
G
K
I
Y
R
V
L
A
G
N
-
P
----
A
K
H
D
L
D
I
K
P
-----
T
V
I
S
--------
H
R
L
H
F
P
E
G
G
S
L
A
A
L
T
A
H
Q
A
C
H
L
P
L
E
T
F
T
R
H
R
Q
P
R
G
W
E
Q
L
E
Q
C
G
Y
P
V
Q
R
L
V
A
L
Y
L
A
A
R
L
S
W
N
Q
V
D
Q
V
I
R
N
A
L
--
A
S
P
--
G
S
G
---
G
D
L
G
--
E
A
I
-
R
E
Q
P
E
Q
A
R
L
A
L
T
L
A
A
A
E
S
E
R
F
V
R
Q
G
T
G
----
N
D
E
A
G
A
A
N
A
D
V
V
S
L
T
C
P
V
A
A
G
E
C
A
G
P
A
D
S
G
D
A
L
L
E
R
N
Y
P
T
G
A
E
F
L
G
D
G
G
D
V
S
F
S
T
R
G
T
Q
N
W
T
V
E
R
L
L
Q
A
H
R
Q
L
E
E
R
G
Y
V
F
V
G
Y
H
G
T
F
L
E
A
A
Q
S
I
V
F
G
G
---
V
---
R
A
R
S
Q
D
L
D
A
I
W
R
G
F
Y
I
A
G
D
P
A
L
A
Y
G
Y
A
Q
D
Q
E
-------
P
D
A
R
-------
G
R
I
R
N
G
A
L
L
R
V
Y
V
P
R
S
S
L
P
G
F
Y
R
T
S
L
T
L
A
A
P
E
A
A
G
E
V
E
R
L
I
G
H
P
L
P
L
R
L
D
A
I
T
G
P
E
E
E
G
G
R
L
E
T
I
L
G
W
P
L
A
E
R
T
V
V
I
P
S
A
I
P
T
D
P
R
N
V
G
G
D
L
D
P
S
S
I
P
D
K
E
Q
A
I
S
A
L
P
D
Y
A
S
Q
P
G
K
-------
54
Fugue
97.06
99%
-100
- C8 -
1IKP
4
TOXA_PSEAE
A:
[2-606]
--------------------------
E
E
A
F
D
L
W
N
E
C
A
K
A
C
V
L
D
L
K
D
G
V
-
R
S
S
R
-
M
S
V
D
P
A
I
A
-----
D
T
N
G
Q
G
V
L
H
Y
S
M
V
L
E
G
G
N
D
A
L
K
L
A
I
D
N
A
--
L
S
I
T
S
D
G
----------------------
L
-
T
I
R
---------------
L
E
G
G
V
E
P
N
K
P
V
R
Y
S
Y
T
R
Q
A
-
R
G
S
W
S
L
N
W
L
V
P
I
G
H
E
K
P
S
N
I
K
V
F
I
H
E
L
N
A
G
N
Q
L
S
H
M
S
P
I
Y
T
I
E
M
G
D
E
L
L
A
--
K
L
A
R
--
D
A
T
F
F
V
R
A
H
E
S
-
N
E
M
Q
P
T
L
A
I
S
H
A
G
V
S
V
V
M
A
Q
------
K
R
W
S
E
W
A
S
G
K
V
L
C
L
L
D
Q
L
D
G
V
Y
N
Y
L
A
Q
Q
R
C
N
L
D
D
T
W
E
G
K
I
Y
R
V
L
A
G
N
-
P
----
A
K
H
D
L
D
I
K
P
-----
T
V
I
S
--------
H
R
L
H
F
P
E
G
G
S
L
A
A
L
T
A
H
Q
A
C
H
L
P
L
E
T
F
T
R
H
R
Q
P
R
G
A
E
Q
L
E
Q
C
G
Y
P
V
Q
R
L
V
A
L
Y
L
A
A
R
L
S
W
N
Q
V
D
Q
V
I
R
N
A
L
--
A
S
P
--
G
S
G
---
G
D
L
G
--
E
A
I
-
R
E
Q
P
E
Q
A
R
L
A
L
T
L
A
A
A
E
S
E
R
F
V
R
Q
G
T
G
----
N
D
E
A
G
A
A
N
A
D
V
V
S
L
T
C
P
V
A
A
G
E
C
A
G
P
A
D
S
G
D
A
L
L
E
R
N
Y
P
T
G
A
E
F
L
G
D
G
G
D
V
S
F
S
T
R
G
T
Q
N
W
T
V
E
R
L
L
Q
A
H
R
Q
L
E
E
R
G
Y
V
F
V
G
Y
H
G
T
F
L
E
A
A
Q
S
I
V
F
G
G
---
V
---
R
A
R
S
Q
D
L
D
A
I
W
R
G
F
Y
I
A
G
D
P
A
L
A
Y
G
Y
A
Q
D
Q
E
-------
P
D
A
R
-------
G
R
I
R
N
G
A
L
L
R
V
Y
V
P
R
S
S
L
P
G
F
Y
R
T
S
L
T
L
A
A
P
E
A
A
G
E
V
E
R
L
I
G
H
P
L
P
L
R
L
D
A
I
T
G
P
E
E
E
G
G
R
L
E
T
I
L
G
W
P
L
A
E
R
T
V
V
I
P
S
A
I
P
T
D
P
R
N
V
G
G
D
L
D
P
S
S
I
P
D
K
E
Q
A
I
S
A
L
P
D
Y
A
S
Q
P
G
K
-------
2
PsiBlast_PDB
97.06
99%
-100
- C8 -
1IKP
4
TOXA_PSEAE
A:
[2-606]
--------------------------
E
E
A
F
D
L
W
N
E
C
A
K
A
C
V
L
D
L
K
D
G
V
-
R
S
S
R
-
M
S
V
D
P
A
I
A
-----
D
T
N
G
Q
G
V
L
H
Y
S
M
V
L
E
G
G
N
D
A
L
K
L
A
I
D
N
A
--
L
S
I
T
S
D
G
----------------------
L
-
T
I
R
---------------
L
E
G
G
V
E
P
N
K
P
V
R
Y
S
Y
T
R
Q
A
-
R
G
S
W
S
L
N
W
L
V
P
I
G
H
E
K
P
S
N
I
K
V
F
I
H
E
L
N
A
G
N
Q
L
S
H
M
S
P
I
Y
T
I
E
M
G
D
E
L
L
A
--
K
L
A
R
--
D
A
T
F
F
V
R
A
H
E
S
-
N
E
M
Q
P
T
L
A
I
S
H
A
G
V
S
V
V
M
A
Q
------
K
R
W
S
E
W
A
S
G
K
V
L
C
L
L
D
Q
L
D
G
V
Y
N
Y
L
A
Q
Q
R
C
N
L
D
D
T
W
E
G
K
I
Y
R
V
L
A
G
N
-
P
----
A
K
H
D
L
D
I
K
P
-----
T
V
I
S
--------
H
R
L
H
F
P
E
G
G
S
L
A
A
L
T
A
H
Q
A
C
H
L
P
L
E
T
F
T
R
H
R
Q
P
R
G
A
E
Q
L
E
Q
C
G
Y
P
V
Q
R
L
V
A
L
Y
L
A
A
R
L
S
W
N
Q
V
D
Q
V
I
R
N
A
L
--
A
S
P
--
G
S
G
---
G
D
L
G
--
E
A
I
-
R
E
Q
P
E
Q
A
R
L
A
L
T
L
A
A
A
E
S
E
R
F
V
R
Q
G
T
G
----
N
D
E
A
G
A
A
N
A
D
V
V
S
L
T
C
P
V
A
A
G
E
C
A
G
P
A
D
S
G
D
A
L
L
E
R
N
Y
P
T
G
A
E
F
L
G
D
G
G
D
V
S
F
S
T
R
G
T
Q
N
W
T
V
E
R
L
L
Q
A
H
R
Q
L
E
E
R
G
Y
V
F
V
G
Y
H
G
T
F
L
E
A
A
Q
S
I
V
F
G
G
---
V
---
R
A
R
S
Q
D
L
D
A
I
W
R
G
F
Y
I
A
G
D
P
A
L
A
Y
G
Y
A
Q
D
Q
E
-------
P
D
A
R
-------
G
R
I
R
N
G
A
L
L
R
V
Y
V
P
R
S
S
L
P
G
F
Y
R
T
S
L
T
L
A
A
P
E
A
A
G
E
V
E
R
L
I
G
H
P
L
P
L
R
L
D
A
I
T
G
P
E
E
E
G
G
R
L
E
T
I
L
G
W
P
L
A
E
R
T
V
V
I
P
S
A
I
P
T
D
P
R
N
V
G
G
D
L
D
P
S
S
I
P
D
K
E
Q
A
I
S
A
L
P
D
Y
A
S
Q
P
G
K
-------
44
HHSearch
94.48
96%
-96
- C8 -
1IKP
4
TOXA_PSEAE
A:
[2-606]
--------------------------
E
E
A
F
D
L
W
N
E
C
A
K
A
C
V
L
D
L
K
D
G
-------
V
R
S
S
R
M
S
V
D
P
A
I
A
D
T
N
G
Q
G
V
L
H
Y
S
M
V
L
E
G
G
--
N
D
A
L
K
L
A
I
D
NA
L
S
I
T
S
D
G
----------------------
L
-
T
I
R
---------------
L
E
G
G
V
E
P
N
K
P
V
R
Y
S
Y
T
R
Q
A
R
G
S
-
W
S
L
N
W
L
V
P
I
G
H
E
K
P
S
N
I
K
V
F
I
H
E
L
N
A
G
N
Q
L
S
H
M
S
P
I
Y
T
I
E
M
G
D
E
L
L
A
--
K
L
A
R
--
D
A
T
F
F
V
R
A
H
E
S
-
N
E
M
Q
P
T
L
A
I
S
H
A
G
V
S
V
V
M
A
Q
------
K
R
W
S
E
W
A
S
G
K
V
L
C
L
L
D
Q
L
D
G
V
Y
N
Y
L
A
Q
Q
R
C
N
L
D
D
T
W
E
G
K
I
Y
R
V
L
A
G
N
P
A
----
K
H
D
-
L
D
I
K
P
-----
T
V
I
S
--------
H
R
L
H
F
P
E
G
G
S
L
A
A
L
T
A
H
Q
A
C
H
L
P
L
E
T
F
T
R
H
R
Q
P
R
G
A
E
Q
L
E
Q
C
G
Y
P
V
Q
R
L
V
A
L
Y
L
A
A
R
L
S
W
N
Q
V
D
Q
V
I
R
N
A
L
--
A
S
P
--
G
S
G
---
G
D
L
G
--
E
A
I
-
R
E
Q
P
E
Q
A
R
L
A
L
T
L
A
A
A
E
S
E
R
F
V
R
Q
G
T
G
----
N
D
E
A
G
A
A
N
A
D
V
V
S
L
T
C
P
V
A
A
G
E
C
A
G
P
A
D
S
G
D
A
L
L
E
R
N
Y
P
T
G
A
E
F
L
G
D
G
G
D
V
S
F
S
T
R
G
T
Q
N
W
T
V
E
R
L
L
Q
A
H
R
Q
L
E
E
R
G
Y
V
F
V
G
Y
H
G
T
F
L
E
A
A
Q
S
I
V
F
G
G
---
V
---
R
A
R
S
Q
D
L
D
A
I
W
R
G
F
Y
I
A
G
D
P
A
L
A
Y
G
Y
A
Q
D
Q
E
-------
P
D
A
R
-------
G
R
I
R
N
G
A
L
L
R
V
Y
V
P
R
S
S
L
P
G
F
Y
R
T
S
L
T
L
A
A
P
E
A
A
G
E
V
E
R
L
I
G
H
P
L
P
L
R
L
D
A
I
T
G
P
E
E
E
G
G
R
L
E
T
I
L
G
W
P
L
A
E
R
T
V
V
I
P
S
A
I
P
T
D
P
R
N
V
G
G
D
L
D
P
S
S
I
P
D
K
E
Q
A
I
S
A
L
P
D
Y
A
S
Q
P
G
K
-------
15
PsiBlast_PDB
72.76
32%
-73
- C8 -
3Q9O
4
CHXA_VIBCL
A:
[13-638]
-----------------------------
L
N
I
F
D
E
C
R
S
P
C
S
L
T
P
E
P
G
K
P
I
Q
S
K
-
L
S
I
P
S
D
V
V
-------
L
D
E
G
V
L
Y
Y
S
M
T
I
N
D
E
Q
--------
K
G
--
E
S
I
I
T
I
G
EF
A
T
V
R
A
T
RHYVNQDAPF
G
V
I
H
L
-
D
I
T
---------------
T
E
N
G
T
K
-----
T
Y
S
Y
N
R
K
--
E
G
E
F
A
I
N
W
L
V
P
I
G
E
D
S
P
A
S
I
K
I
S
V
D
E
L
D
Q
Q
R
N
I
I
E
V
P
K
L
Y
S
I
D
L
D
N
Q
T
L
E
Q
W
K
T
Q
G
--
N
V
S
F
S
V
T
R
P
E
H
-
N
-----
I
A
I
S
W
P
S
V
S
Y
K
A
A
Q
K
E
G
S
R
H
K
R
W
A
H
W
H
T
G
L
A
L
C
W
L
V
P
M
D
A
I
Y
N
-----
N
C
---------
S
Y
E
T
V
A
G
T
-
P
K
V
I
T
V
K
Q
G
I
E
Q
K
P
-------
V
E
--------
Q
R
I
H
F
S
K
G
N
A
M
S
A
L
A
A
H
R
V
C
G
V
P
L
E
T
L
A
R
S
R
K
P
R
D
L
T
D
D
L
S
C
A
Y
Q
A
Q
N
I
V
S
L
F
V
A
T
R
I
L
F
S
H
L
D
S
V
F
T
L
N
L
DE
Q
E
P
--
E
V
A
E
R
L
S
D
L
R
--
R
I
N
-
E
N
N
P
G
M
V
T
Q
V
L
T
V
A
R
Q
I
Y
N
D
Y
V
T
H
H
P
G
LT
P
E
Q
T
S
A
G
A
Q
A
A
D
I
L
S
L
F
C
P
D
A
D
K
S
C
V
A
-
S
N
N
D
Q
A
N
I
N
I
E
S
R
S
G
R
S
Y
L
P
E
N
R
A
V
-
I
T
P
Q
G
V
T
N
W
T
Y
Q
E
L
E
A
T
H
Q
A
L
T
R
E
G
Y
V
F
V
G
Y
H
G
T
N
H
V
A
A
Q
T
I
V
N
R
I
---
A
P
V
P
R
G
N
N
T
E
N
E
E
K
W
G
G
L
Y
V
A
T
H
A
E
V
A
H
G
Y
A
R
I
K
E
GTGEYGL
P
T
R
A
-------
E
R
D
A
R
G
V
M
L
R
V
Y
I
P
R
A
S
L
E
R
F
Y
R
T
N
T
P
L
E
N
A
E
E
--
H
I
T
Q
V
I
G
H
S
L
P
L
R
N
E
A
F
T
G
P
E
S
A
G
G
E
D
E
T
V
I
G
W
D
M
A
I
H
A
V
A
I
P
S
T
I
P
G
N
A
Y
E
E
L
A
-
I
D
E
E
A
V
A
-
K
E
Q
S
I
S
T
K
P
P
Y
-----
K
E
R
K
----
14
PsiBlast_PDB
72.66
32%
-70
- C8 -
2Q5T
10
CHXA_VIBCL
A:
[13-638]
-----------------------------
L
N
I
F
D
E
C
R
S
P
C
S
L
T
P
E
P
G
K
P
I
Q
S
K
-
L
S
I
P
S
D
V
V
-------
L
D
E
G
V
L
Y
Y
S
M
T
I
N
D
E
Q
--------
K
G
--
E
S
I
I
T
I
G
EF
A
T
V
R
A
T
RHYVNQDAPF
G
V
I
H
L
-
D
I
T
---------------
T
E
N
G
T
K
-----
T
Y
S
Y
N
R
K
--
E
G
E
F
A
I
N
W
L
V
P
I
G
E
D
S
P
A
S
I
K
I
S
V
D
E
L
D
Q
Q
R
N
I
I
E
V
P
K
L
Y
S
I
D
L
D
N
Q
T
L
E
Q
W
K
T
Q
G
--
N
V
S
F
S
V
T
R
P
E
H
-
N
-----
I
A
I
S
W
P
S
V
S
Y
K
A
A
Q
K
E
G
S
R
H
K
R
W
A
H
W
H
T
G
L
A
L
C
W
L
V
P
M
D
A
I
Y
N
-----
N
C
---------
S
Y
E
T
V
A
G
T
-
P
K
V
I
T
V
K
Q
G
I
E
Q
K
P
-------
V
E
--------
Q
R
I
H
F
S
K
G
N
A
M
S
A
L
A
A
H
R
V
C
G
V
P
L
E
T
L
A
R
S
R
K
P
R
D
L
T
D
D
L
S
C
A
Y
Q
A
Q
N
I
V
S
L
F
V
A
T
R
I
L
F
S
H
L
D
S
V
F
T
L
N
L
DE
Q
E
P
--
E
V
A
E
R
L
S
D
L
R
--
R
I
N
-
E
N
N
P
G
M
V
T
Q
V
L
T
V
A
R
Q
I
Y
N
D
Y
V
T
H
H
P
G
LT
P
E
Q
T
S
A
G
A
Q
A
A
D
I
L
S
L
F
C
P
D
A
D
K
S
C
V
A
-
S
N
N
D
Q
A
N
I
N
I
E
S
R
S
G
R
S
Y
L
P
E
N
R
A
V
-
I
T
P
Q
G
V
T
N
W
T
Y
Q
E
L
E
A
T
H
Q
A
L
T
R
E
G
Y
V
F
V
G
Y
H
G
T
N
H
V
A
A
Q
T
I
V
N
R
I
---
A
P
V
P
R
G
N
N
T
E
N
E
E
K
W
G
G
L
Y
V
A
T
H
A
E
V
A
H
G
Y
A
R
I
K
E
GTGEYG
L
P
T
R
A
-------
E
R
D
A
R
G
V
M
L
R
V
Y
I
P
R
A
S
L
E
R
F
Y
R
T
N
T
P
L
E
N
A
E
E
--
H
I
T
Q
V
I
G
H
S
L
P
L
R
N
E
A
F
T
G
P
E
S
A
G
G
E
D
E
T
V
I
G
W
D
M
A
I
H
A
V
A
I
P
S
T
I
P
G
N
A
Y
E
E
L
A
-
I
D
E
E
A
V
A
-
K
E
Q
S
I
S
T
K
P
P
Y
-----
K
E
R
K
----
45
HHSearch
68.42
33%
-63
- C8 -
3Q9O
4
CHXA_VIBCL
A:
[13-638]
-----------------------------
L
N
I
F
D
E
C
R
S
P
C
S
L
T
P
E
P
G
K
-
P
I
Q
S
K
L
S
I
P
S
--
D
-----
V
V
L
D
E
G
V
L
Y
Y
S
M
T
I
N
D
E
Q
-------
K
G
E
--
S
I
I
T
I
G
E
----------------------
F
A
T
V
R
A
T
RHYVNQDAPF
G
V
I
H
L
D
I
T
T
E
N
G
T
K
T
Y
S
Y
N
R
K
--
E
G
E
F
A
I
N
W
L
V
P
I
G
E
D
S
P
A
S
I
K
I
S
V
D
E
L
D
Q
Q
R
N
I
I
E
V
P
K
L
Y
S
I
D
L
D
N
Q
T
L
E
--
Q
W
K
T
Q
G
N
V
S
F
S
V
T
R
P
E
H
N
I
A
I
S
W
P
S
V
S
Y
K
---
A
A
Q
K
E
G
S
R
H
K
R
W
A
H
W
---
H
T
G
L
A
L
C
W
L
V
P
M
D
A
I
Y
N
-----
N
C
------------------------
S
Y
-
E
T
V
A
G
T
P
K
V
I
T
V
K
Q
GIEQKPV
E
Q
R
I
H
F
S
K
G
N
A
M
S
A
L
A
A
H
R
V
C
G
V
P
L
E
T
L
A
R
S
R
K
P
R
D
L
T
D
D
L
S
C
A
Y
Q
A
Q
N
I
V
S
L
F
V
A
T
R
I
L
F
S
H
L
D
S
V
F
T
L
N
L
--
D
E
Q
E
P
E
V
A
---
E
R
L
S
D
L
R
R
I
N
E
N
N
P
G
M
V
T
Q
V
L
T
V
A
R
Q
I
Y
N
D
Y
V
T
H
H
P
G
LT
P
E
Q
T
S
A
G
A
Q
A
A
D
I
L
S
L
F
C
P
D
A
D
K
S
C
V
A
S
N
N
D
Q
A
N
-
I
N
I
E
S
R
S
G
R
S
Y
L
P
E
N
R
A
-
V
I
T
P
Q
G
V
T
N
W
T
Y
Q
E
L
E
A
T
H
Q
A
L
T
R
E
G
Y
V
F
V
G
Y
H
G
T
N
H
V
A
A
Q
T
I
V
N
R
I
A
P
V
P
---
R
G
N
N
T
E
N
E
E
K
W
G
G
L
Y
V
A
T
H
A
E
V
A
H
G
Y
A
R
I
K
E
GTGEYGL
P
T
R
A
-------
E
R
D
A
R
G
V
M
L
R
V
Y
I
P
R
A
S
L
E
R
F
Y
R
T
N
T
P
L
E
N
A
--
E
E
H
I
T
Q
V
I
G
H
S
L
P
L
R
N
E
A
F
T
G
P
E
S
A
G
G
E
D
E
T
V
I
G
W
D
M
A
I
H
A
V
A
I
P
S
T
I
P
G
N
A
Y
E
E
L
A
-
I
D
E
-
E
A
V
A
K
E
Q
S
I
S
T
K
P
P
Y
K
E
R
K
---------
23
PsiBlast_CBE
62.82
99%
-108
- C8 -
1AER
2
B:
[2-202]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
G
D
G
G
D
V
S
F
S
T
R
G
T
Q
N
W
T
V
E
R
L
L
Q
A
H
R
Q
L
E
E
R
G
Y
V
F
V
G
Y
H
G
T
F
L
E
A
A
Q
S
I
V
F
G
G
---
V
---
R
A
R
S
Q
D
L
D
A
I
W
R
G
F
Y
I
A
G
D
P
A
L
A
Y
G
Y
A
Q
D
Q
E
-------
P
D
-
R
-------
G
R
I
R
N
G
A
L
L
R
V
Y
V
P
R
S
S
L
P
G
F
Y
R
T
S
L
T
L
A
A
P
E
A
A
G
E
V
E
R
L
I
G
H
P
L
P
L
R
L
D
A
I
T
G
P
-----
R
L
E
T
I
L
G
W
P
L
A
E
R
T
V
V
I
P
S
A
I
P
T
D
P
R
N
V
G
G
D
L
D
P
S
S
I
P
D
K
E
Q
A
I
S
A
L
P
D
Y
-------------
29
PsiBlast_CBE
62.75
99%
-95
- C8 -
2ZIT
1
F:
[2-207]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
G
D
G
G
D
V
S
F
S
T
R
G
T
Q
N
W
T
V
E
R
L
L
Q
A
H
R
Q
L
E
E
R
G
Y
V
F
V
G
Y
H
G
T
F
L
E
A
A
Q
S
I
V
F
G
G
---
V
---
R
A
R
S
Q
D
L
D
A
I
W
R
G
F
Y
I
A
G
D
P
A
L
A
Y
G
Y
A
Q
D
Q
E
-------
P
D
A
R
-------
G
R
I
R
N
G
A
L
L
R
V
Y
V
P
R
S
S
L
P
G
F
Y
R
T
S
L
T
L
A
A
P
E
A
A
G
E
V
E
R
L
I
G
H
P
L
P
L
R
L
D
A
I
T
G
P
E
E
E
G
G
R
L
E
T
I
L
G
W
P
L
A
E
R
T
V
V
I
P
S
A
I
P
T
D
P
R
N
V
G
G
D
L
D
P
S
S
I
P
D
K
E
Q
A
I
S
A
L
P
D
Y
A
S
Q
P
G
--------
34
PsiBlast_CBE
62.60
98%
-94
- C8 -
3B78
1
TOXA_PSEAE
D:
[2-207]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
G
D
G
G
D
V
S
F
S
T
R
G
T
Q
N
W
T
V
E
R
L
L
Q
A
H
R
Q
L
E
E
R
G
Y
V
F
V
G
Y
H
G
T
F
L
E
A
A
Q
S
I
V
F
G
G
---
V
---
R
A
R
S
Q
D
L
D
A
I
W
R
G
F
Y
I
A
G
D
P
A
L
A
Y
G
Y
A
Q
D
Q
E
-------
P
D
A
R
-------
G
R
I
R
N
G
A
L
L
R
V
Y
V
P
R
S
S
L
P
G
F
Y
R
T
S
L
T
L
A
A
P
E
A
A
G
E
V
E
R
L
I
G
H
P
L
P
L
R
L
D
A
I
T
G
P
E
E
E
G
G
H
L
E
T
I
L
G
W
P
L
A
E
R
T
V
V
I
P
S
A
I
P
T
D
P
R
N
V
G
G
D
L
D
P
S
S
I
P
D
K
E
Q
A
I
S
A
L
P
D
Y
A
S
Q
P
G
--------
31
PsiBlast_CBE
62.55
98%
-94
- C8 -
3B82
1
F:
[2-207]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
G
D
G
G
D
V
S
F
S
T
R
G
T
Q
N
W
T
V
E
R
L
L
Q
A
H
R
Q
L
E
E
R
G
Y
V
F
V
G
Y
H
G
T
F
L
E
A
A
Q
S
I
V
F
G
G
---
V
---
R
A
R
S
Q
D
L
D
A
I
W
R
G
F
Y
I
A
G
D
P
A
L
A
Y
G
Y
A
Q
D
Q
E
-------
P
D
A
R
-------
G
R
I
R
N
G
A
L
L
R
V
Y
V
P
R
S
S
L
P
G
F
Y
R
T
S
L
T
L
A
A
P
E
A
A
G
E
V
E
R
L
I
G
H
P
L
P
L
R
L
D
A
I
T
G
P
H
E
E
G
G
R
L
E
T
I
L
G
W
P
L
A
E
R
T
V
V
I
P
S
A
I
P
T
D
P
R
N
V
G
G
D
L
D
P
S
S
I
P
D
K
E
Q
A
I
S
A
L
P
D
Y
A
S
Q
P
G
--------
32
PsiBlast_CBE
62.52
98%
-95
- C8 -
3B82
1
TOXA_PSEAE
D:
[2-207]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
G
D
G
G
D
V
S
F
S
T
R
G
T
Q
N
W
T
V
E
R
L
L
Q
A
H
R
Q
L
E
E
R
G
Y
V
F
V
G
Y
H
G
T
F
L
E
A
A
Q
S
I
V
F
G
G
---
V
---
R
A
R
S
Q
D
L
D
A
I
W
R
G
F
Y
I
A
G
D
P
A
L
A
Y
G
Y
A
Q
D
Q
E
-------
P
D
A
R
-------
G
R
I
R
N
G
A
L
L
R
V
Y
V
P
R
S
S
L
P
G
F
Y
R
T
S
L
T
L
A
A
P
E
A
A
G
E
V
E
R
L
I
G
H
P
L
P
L
R
L
D
A
I
T
G
P
H
E
E
G
G
R
L
E
T
I
L
G
W
P
L
A
E
R
T
V
V
I
P
S
A
I
P
T
D
P
R
N
V
G
G
D
L
D
P
S
S
I
P
D
K
E
Q
A
I
S
A
L
P
D
Y
A
S
Q
P
G
--------
36
PsiBlast_CBE
62.46
98%
-96
- C8 -
3B8H
1
TOXA_PSEAE
D:
[2-207]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
G
D
G
G
D
V
S
F
S
T
R
G
T
Q
N
W
T
V
E
R
L
L
Q
A
H
R
Q
L
E
E
R
G
Y
V
F
V
G
Y
H
G
T
F
L
E
A
A
Q
S
I
V
F
G
G
---
V
---
R
A
R
S
Q
D
L
D
A
I
W
R
G
F
Y
I
A
G
D
P
A
L
A
Y
G
Y
A
Q
D
Q
E
-------
P
D
A
R
-------
G
R
I
R
N
G
A
L
L
R
V
Y
V
P
R
S
S
L
P
G
F
Y
R
T
S
L
T
L
A
A
P
E
A
A
G
E
V
E
R
L
I
G
H
P
L
P
L
R
L
D
A
I
T
G
P
A
E
E
G
G
R
L
E
T
I
L
G
W
P
L
A
E
R
T
V
V
I
P
S
A
I
P
T
D
P
R
N
V
G
G
D
L
D
P
S
S
I
P
D
K
E
Q
A
I
S
A
L
P
D
Y
A
S
Q
P
G
--------
3
PsiBlast_PDB
62.46
99%
-95
- C8 -
1XK9
1
TOXA_PSEAE
A:
[1-204]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
L
G
D
G
G
D
V
S
F
S
T
R
G
T
Q
N
W
T
V
E
R
L
L
Q
A
H
R
Q
L
E
E
R
G
Y
V
F
V
G
Y
H
G
T
F
L
E
A
A
Q
S
I
V
F
G
G
---
V
---
R
A
R
S
Q
D
L
D
A
I
W
R
G
F
Y
I
A
G
D
P
A
L
A
Y
G
Y
A
Q
D
Q
E
-------
P
D
A
R
-------
G
R
I
R
N
G
A
L
L
R
V
Y
V
P
R
S
S
L
P
G
F
Y
R
T
S
L
T
L
A
A
P
E
A
A
G
E
V
E
R
L
I
G
H
P
L
P
L
R
L
D
A
I
T
G
P
E
E
E
G
G
R
L
E
T
I
L
G
W
P
L
A
E
R
T
V
V
I
P
S
A
I
P
T
D
P
R
N
V
G
G
D
L
D
P
S
S
I
P
D
K
E
Q
A
I
S
A
L
P
D
Y
A
S
-----------
6
PsiBlast_PDB
62.44
99%
-92
- C8 -
1ZM2
-
TOXA_PSEAE
B:
[1-207]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
L
G
D
G
G
D
V
S
F
S
T
R
G
T
Q
N
W
T
V
E
R
L
L
Q
A
H
R
Q
L
E
E
R
G
Y
V
F
V
G
Y
H
G
T
F
L
E
A
A
Q
S
I
V
F
G
G
---
V
---
R
A
R
S
Q
D
L
D
A
I
W
R
G
F
Y
I
A
G
D
P
A
L
A
Y
G
Y
A
Q
D
Q
E
-------
P
D
A
R
-------
G
R
I
R
N
G
A
L
L
R
V
Y
V
P
R
S
S
L
P
G
F
Y
R
T
S
L
T
L
A
A
P
E
A
A
G
E
V
E
R
L
I
G
H
P
L
P
L
R
L
D
A
I
T
G
P
E
E
E
G
G
R
L
E
T
I
L
G
W
P
L
A
E
R
T
V
V
I
P
S
A
I
P
T
D
P
R
N
V
G
G
D
L
D
P
S
S
I
P
D
K
E
Q
A
I
S
A
L
P
D
Y
A
S
Q
P
G
--------
33
PsiBlast_CBE
62.43
98%
-95
- C8 -
3B78
1
F:
[2-207]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
G
D
G
G
D
V
S
F
S
T
R
G
T
Q
N
W
T
V
E
R
L
L
Q
A
H
R
Q
L
E
E
R
G
Y
V
F
V
G
Y
H
G
T
F
L
E
A
A
Q
S
I
V
F
G
G
---
V
---
R
A
R
S
Q
D
L
D
A
I
W
R
G
F
Y
I
A
G
D
P
A
L
A
Y
G
Y
A
Q
D
Q
E
-------
P
D
A
R
-------
G
R
I
R
N
G
A
L
L
R
V
Y
V
P
R
S
S
L
P
G
F
Y
R
T
S
L
T
L
A
A
P
E
A
A
G
E
V
E
R
L
I
G
H
P
L
P
L
R
L
D
A
I
T
G
P
E
E
E
G
G
H
L
E
T
I
L
G
W
P
L
A
E
R
T
V
V
I
P
S
A
I
P
T
D
P
R
N
V
G
G
D
L
D
P
S
S
I
P
D
K
E
Q
A
I
S
A
L
P
D
Y
A
S
Q
P
G
--------
10
PsiBlast_PDB
62.32
99%
-96
- C8 -
2ZIT
1
TOXA_PSEAE
B:
[2-207]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
G
D
G
G
D
V
S
F
S
T
R
G
T
Q
N
W
T
V
E
R
L
L
Q
A
H
R
Q
L
E
E
R
G
Y
V
F
V
G
Y
H
G
T
F
L
E
A
A
Q
S
I
V
F
G
G
---
V
---
R
A
R
S
Q
D
L
D
A
I
W
R
G
F
Y
I
A
G
D
P
A
L
A
Y
G
Y
A
Q
D
Q
E
-------
P
D
A
R
-------
G
R
I
R
N
G
A
L
L
R
V
Y
V
P
R
S
S
L
P
G
F
Y
R
T
S
L
T
L
A
A
P
E
A
A
G
E
V
E
R
L
I
G
H
P
L
P
L
R
L
D
A
I
T
G
P
E
E
E
G
G
R
L
E
T
I
L
G
W
P
L
A
E
R
T
V
V
I
P
S
A
I
P
T
D
P
R
N
V
G
G
D
L
D
P
S
S
I
P
D
K
E
Q
A
I
S
A
L
P
D
Y
A
S
Q
P
G
--------
5
PsiBlast_PDB
62.28
99%
-96
- C8 -
1AER
1
TOXA_PSEAE
A:
[2-211]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
G
D
G
G
D
V
S
F
S
T
R
G
T
Q
N
W
T
V
E
R
L
L
Q
A
H
R
Q
L
E
E
R
G
Y
V
F
V
G
Y
H
G
T
F
L
E
A
A
Q
S
I
V
F
G
G
---
V
---
R
A
------
A
I
W
R
G
F
Y
I
A
G
D
P
A
L
A
Y
G
Y
A
Q
D
Q
E
-------
P
D
A
R
-------
G
R
I
R
N
G
A
L
L
R
V
Y
V
P
R
S
S
L
P
G
F
Y
R
T
S
L
T
L
A
A
P
E
A
A
G
E
V
E
R
L
I
G
H
P
L
P
L
R
L
D
A
I
T
G
P
E
E
E
G
G
R
L
E
T
I
L
G
W
P
L
A
E
R
T
V
V
I
P
S
A
I
P
T
D
P
R
N
V
G
G
D
L
D
P
S
S
I
P
D
K
E
Q
A
I
S
A
L
P
D
Y
A
S
Q
P
G
K
P
P
R
----
35
PsiBlast_CBE
62.22
98%
-94
- C8 -
3B8H
1
F:
[2-207]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
G
D
G
G
D
V
S
F
S
T
R
G
T
Q
N
W
T
V
E
R
L
L
Q
A
H
R
Q
L
E
E
R
G
Y
V
F
V
G
Y
H
G
T
F
L
E
A
A
Q
S
I
V
F
G
G
---
V
---
R
A
R
S
Q
D
L
D
A
I
W
R
G
F
Y
I
A
G
D
P
A
L
A
Y
G
Y
A
Q
D
Q
E
-------
P
D
A
R
-------
G
R
I
R
N
G
A
L
L
R
V
Y
V
P
R
S
S
L
P
G
F
Y
R
T
S
L
T
L
A
A
P
E
A
A
G
E
V
E
R
L
I
G
H
P
L
P
L
R
L
D
A
I
T
G
P
A
E
E
G
G
R
L
E
T
I
L
G
W
P
L
A
E
R
T
V
V
I
P
S
A
I
P
T
D
P
R
N
V
G
G
D
L
D
P
S
S
I
P
D
K
E
Q
A
I
S
A
L
P
D
Y
A
S
Q
P
G
--------
11
PsiBlast_PDB
62.18
98%
-97
- C8 -
3B82
1
TOXA_PSEAE
B:
[2-207]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
G
D
G
G
D
V
S
F
S
T
R
G
T
Q
N
W
T
V
E
R
L
L
Q
A
H
R
Q
L
E
E
R
G
Y
V
F
V
G
Y
H
G
T
F
L
E
A
A
Q
S
I
V
F
G
G
---
V
---
R
A
R
S
Q
D
L
D
A
I
W
R
G
F
Y
I
A
G
D
P
A
L
A
Y
G
Y
A
Q
D
Q
E
-------
P
D
A
R
-------
G
R
I
R
N
G
A
L
L
R
V
Y
V
P
R
S
S
L
P
G
F
Y
R
T
S
L
T
L
A
A
P
E
A
A
G
E
V
E
R
L
I
G
H
P
L
P
L
R
L
D
A
I
T
G
P
H
E
E
G
G
R
L
E
T
I
L
G
W
P
L
A
E
R
T
V
V
I
P
S
A
I
P
T
D
P
R
N
V
G
G
D
L
D
P
S
S
I
P
D
K
E
Q
A
I
S
A
L
P
D
Y
A
S
Q
P
G
--------
55
Fugue
62.09
98%
-94
* C8 *
1AER
1
TOXA_PSEAE
A:
[1-211]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
L
G
D
G
G
D
V
S
F
S
T
R
G
T
Q
N
W
T
V
E
R
L
L
Q
A
H
R
Q
L
E
E
R
G
Y
V
F
V
G
Y
H
G
T
F
L
E
A
A
Q
S
I
V
F
G
G
---
V
---
R
A
------
A
I
W
R
G
F
Y
I
A
G
D
P
A
L
A
Y
G
Y
A
Q
D
Q
E
-------
P
D
A
R
-------
G
R
I
R
N
G
A
L
L
R
V
Y
V
P
R
S
S
L
P
G
F
Y
R
T
S
L
T
L
A
A
P
E
A
A
G
E
V
E
R
L
I
G
H
P
L
P
L
R
L
D
A
I
T
G
P
E
E
E
G
G
R
L
E
T
I
L
G
W
P
L
A
E
R
T
V
V
I
P
S
A
I
P
T
D
P
R
N
V
G
G
D
L
D
P
S
S
I
P
D
K
E
Q
A
I
S
A
L
P
D
Y
A
S
Q
P
G
K
P
P
R
----
21
PsiBlast_CBE
61.71
99%
-96
- C8 -
1XK9
1
B:
[1-204]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
L
G
D
G
G
D
V
S
F
S
T
R
G
T
Q
N
W
T
V
E
R
L
L
Q
A
H
R
Q
L
E
E
R
G
Y
V
F
V
G
Y
H
G
T
F
L
E
A
A
Q
S
I
V
F
G
G
---
V
---
R
A
R
------
I
W
R
G
F
Y
I
A
G
D
P
A
L
A
Y
G
Y
A
Q
D
Q
E
-------
P
D
A
R
-------
G
R
I
R
N
G
A
L
L
R
V
Y
V
P
R
S
S
L
P
G
F
Y
R
T
S
L
T
L
A
A
P
E
A
A
G
E
V
E
R
L
I
G
H
P
L
P
L
R
L
D
A
I
T
G
P
E
E
E
G
G
R
L
E
T
I
L
G
W
P
L
A
E
R
T
V
V
I
P
S
A
I
P
T
D
P
R
N
V
G
G
D
L
D
P
S
S
I
P
D
K
E
Q
A
I
S
A
L
P
D
Y
A
S
-----------
22
PsiBlast_CBE
61.60
99%
-98
- C8 -
1DMA
2
B:
[1-200]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
G
D
G
G
D
V
S
F
S
T
R
G
T
Q
N
W
T
V
E
R
L
L
Q
A
H
R
Q
L
E
E
R
G
Y
V
F
V
G
Y
H
G
T
F
L
E
A
A
Q
S
I
V
F
G
G
---
V
---
R
A
R
S
Q
D
L
D
A
I
W
R
G
F
Y
I
A
G
D
P
A
L
A
Y
G
Y
A
Q
-----------------------
I
R
N
G
A
L
L
R
V
Y
V
P
R
S
S
L
P
G
F
Y
R
T
S
L
T
L
A
A
P
E
A
A
G
E
V
E
R
L
I
G
H
P
L
P
L
R
L
D
A
I
T
G
P
E
E
E
G
G
R
L
E
T
I
L
G
W
P
L
A
E
R
T
V
V
I
P
S
A
I
P
T
D
P
R
N
V
--
D
L
D
P
S
S
I
P
D
K
E
Q
A
I
S
A
L
P
D
--------------
16
PsiBlast_PDB
51.53
40%
-69
- C8 -
3KI0
3
A:
[7-206]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
P
Q
G
V
T
N
W
T
Y
Q
E
L
E
A
T
H
Q
A
L
T
R
E
G
Y
V
F
V
G
Y
H
G
T
N
H
V
A
A
Q
T
I
V
N
R
I
---
A
PV-------
N
E
E
K
W
G
G
L
Y
V
A
T
H
A
E
V
A
H
G
Y
A
R
I
K
E
GTGEYGL
P
T
R
A
-------
E
R
D
A
R
G
V
M
L
R
V
Y
I
P
R
A
S
L
E
R
F
Y
R
T
N
T
P
L
E
N
A
E
E
--
H
I
T
Q
V
I
G
H
S
L
P
L
R
N
E
A
F
T
G
P
E
S
A
G
G
E
D
E
T
V
I
G
W
D
M
A
I
H
A
V
A
I
P
S
T
I
P
G
N
A
Y
E
E
L
A
-
I
D
E
E
A
V
A
-
K
E
Q
S
I
S
T
K
P
P
Y
K
E
-----------
39
PsiBlast_CBE
51.25
40%
-67
- C8 -
3KI6
1
A:
[7-206]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
P
Q
G
V
T
N
W
T
Y
Q
E
L
E
A
T
H
Q
A
L
T
R
E
G
Y
V
F
V
G
Y
H
G
T
N
H
V
A
A
Q
T
I
V
N
R
I
---
A
P--------
N
E
E
K
W
G
G
L
Y
V
A
T
H
A
E
V
A
H
G
Y
A
R
I
K
E
GTGEYGL
P
T
R
A
-------
E
R
D
A
R
G
V
M
L
R
V
Y
I
P
R
A
S
L
E
R
F
Y
R
T
N
T
P
L
E
N
A
E
E
--
H
I
T
Q
V
I
G
H
S
L
P
L
R
N
E
A
F
T
G
P
E
S
A
G
G
E
D
E
T
V
I
G
W
D
M
A
I
H
A
V
A
I
P
S
T
I
P
G
N
A
Y
E
E
L
A
-
I
D
E
E
A
V
A
-
K
E
Q
S
I
S
T
K
P
P
Y
K
E
-----------
20
PsiBlast_PDB
51.25
40%
-66
- C8 -
3KI4
3
A:
[7-206]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
P
Q
G
V
T
N
W
T
Y
Q
E
L
E
A
T
H
Q
A
L
T
R
E
G
Y
V
F
V
G
Y
H
G
T
N
H
V
A
A
Q
T
I
V
N
R
I
---
A
P
V-----
T
E
N
E
E
K
W
G
G
L
Y
V
A
T
H
A
E
V
A
H
G
Y
A
R
I
K
E
GTGEYGL
P
T
R
A
-------
E
R
D
A
R
G
V
M
L
R
V
Y
I
P
R
A
S
L
E
R
F
Y
R
T
N
T
P
L
E
N
A
E
E
--
H
I
T
Q
V
I
G
H
S
L
P
L
R
N
E
A
F
T
G
P
E
S
A
G
G
E
D
E
T
V
I
G
W
D
M
A
I
H
A
V
A
I
P
S
T
I
P
G
N
A
Y
E
E
L
A
-
I
D
E
E
A
V
A
-
K
E
Q
S
I
S
T
K
P
P
Y
K
E
-----------
37
PsiBlast_CBE
51.02
40%
-65
- C8 -
3NY6
4
A:
[7-207]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
P
Q
G
V
T
N
W
T
Y
Q
E
L
E
A
T
H
Q
A
L
T
R
E
G
Y
V
F
V
G
Y
H
G
T
N
H
V
A
A
Q
T
I
V
N
R
I
---
A
P
V-------
N
E
E
K
W
G
G
L
Y
V
A
T
H
A
E
V
A
H
G
Y
A
R
I
K
E
GTGEYGL
P
T
R
A
-------
E
R
D
A
R
G
V
M
L
R
V
Y
I
P
R
A
S
L
E
R
F
Y
R
T
N
T
P
L
E
N
A
E
E
--
H
I
T
Q
V
I
G
H
S
L
P
L
R
N
E
A
F
T
G
P
E
S
A
G
G
E
D
E
T
V
I
G
W
D
M
A
I
H
A
V
A
I
P
S
T
I
P
G
N
A
Y
E
E
L
A
-
I
D
E
E
A
V
A
-
K
E
Q
S
I
S
T
K
P
P
Y
K
E
R
----------
46
HHSearch
50.82
39%
-71
- C8 -
3ESS
1
A:
[23-227]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
V
I
T
P
Q
G
V
T
N
W
T
Y
Q
E
L
E
A
T
H
Q
A
L
T
R
E
G
Y
V
F
V
G
Y
H
G
T
N
H
V
A
A
Q
T
I
V
N
R
I
A
P
-
V
-----------
E
K
W
G
G
L
Y
V
A
T
H
A
E
V
A
H
G
Y
A
R
I
K
E
-------
G
T
G
E
YGLPT
R
A
E
R
D
A
R
G
V
M
L
R
V
Y
I
P
R
A
S
L
E
R
F
Y
R
T
N
T
P
L
E
N
A
--
E
E
H
I
T
Q
V
I
G
H
S
L
P
L
R
N
E
A
F
T
G
P
E
S
A
G
G
E
D
E
T
V
I
G
W
D
M
A
I
H
A
V
A
I
P
S
T
I
P
G
N
A
Y
E
E
L
A
-
I
D
E
-
E
A
V
A
K
E
Q
S
I
S
T
K
P
P
Y
K
E
R
K
D
E
L
------
17
PsiBlast_PDB
50.64
40%
-66
- C8 -
3KI1
2
A:
[7-206]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
P
Q
G
V
T
N
W
T
Y
Q
E
L
E
A
T
H
Q
A
L
T
R
E
G
Y
V
F
V
G
Y
H
G
T
N
H
V
A
A
Q
T
I
V
N
R
I
---
A
P----------
E
K
W
G
G
L
Y
V
A
T
H
A
E
V
A
H
G
Y
A
R
I
K
E
GTGEYGL
P
T
R
A
-------
E
R
D
A
R
G
V
M
L
R
V
Y
I
P
R
A
S
L
E
R
F
Y
R
T
N
T
P
L
E
N
A
E
E
--
H
I
T
Q
V
I
G
H
S
L
P
L
R
N
E
A
F
T
G
P
E
S
A
G
G
E
D
E
T
V
I
G
W
D
M
A
I
H
A
V
A
I
P
S
T
I
P
G
N
A
Y
E
E
L
A
-
I
D
E
E
A
V
A
-
K
E
Q
S
I
S
T
K
P
P
Y
K
E
-----------
18
PsiBlast_PDB
50.46
40%
-65
- C8 -
3KI2
2
A:
[7-206]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
P
Q
G
V
T
N
W
T
Y
Q
E
L
E
A
T
H
Q
A
L
T
R
E
G
Y
V
F
V
G
Y
H
G
T
N
H
V
A
A
Q
T
I
V
N
R
I
---
A
P--------
N
E
E
K
W
G
G
L
Y
V
A
T
H
A
E
V
A
H
G
Y
A
R
I
K
E
GTGEYGL
P
T
R
A
-------
E
R
D
A
R
G
V
M
L
R
V
Y
I
P
R
A
S
L
E
R
F
Y
R
T
N
T
P
L
E
N
A
E
E
--
H
I
T
Q
V
I
G
H
S
L
P
L
R
N
E
A
F
T
G
P
E
S
A
G
G
E
D
E
T
V
I
G
W
D
M
A
I
H
A
V
A
I
P
S
T
I
P
G
N
A
Y
E
E
L
A
-
I
D
E
E
A
V
A
-
K
E
Q
S
I
S
T
K
P
P
Y
K
E
-----------