@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
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Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA1174: (2016-01-27 )
MNSPRPTPPPFAAAAAGLPILVRASNLVTEADVTSLVWNKAPCRFCGTGCSVMVATRDGQVVATHGDIKAEVNRGINCVKGYFLSKIMYGSDRLTRPLLRMKDGKFDKQGEFQPISWEQAFDIMAEKFKAALKAKGPESVGMFGSGQWTVWEGYAANKLFKAGLRSNNIDPNARHCMASAVMGFMRSFGMDEPMGCYDDIEATDSFVLWGSNMAEMHPVLWSRVTDRRLSAPQVKVAVLSTFEHRSFELADLPMVFKPQTDLIILNYIANHIIESGAVNRDFVERHVRFAHGAEDIGYGLRPDDPLEKKAKNADKANTWSDIDFKAFAEFVKPYTLERTARESGVPAERLKALAELYADPKRKVVSFWTMGFNQHTRGVWANNLIYNIHLLTGKISEPGNSPFSLTGQPSACGTAREVGTFSHRLPADLVVTNPKHRETAEKIWKVPAGTIQEKVGFHAVQQSRMLKDGVLNVYWTQVSNNMQAGPNVMQEVLPGWRNPDNFVIVSDVYPTVSAQAADLILPSAMWVEKEGAFGNAERRTQFWHQLVKAPGEAKSDLWQLVEFSKRFTTDEVWPAELLAKAPELKGKTLYDVLFRNGQVDRFPASDLAKGYANDEVDAFGFYIQKGLFEEYAAFGRGHGHDLAPFDAYHEARGLRWPVVDGKETRWRYREGYDPYVSKGSGVQFYGYPDKKAIVFALPYEPPAEAPDQDYPFWLATGRVLEHWHTGSMTARVPELYKAVPDALVYMHPEDARQLKLRRGSEVKVVSRRGEIRARVETRGRNKPPQGLVFVPFFDANKLINKVTLDATDPISKQTDYKKCAVRIELLNLA
Atome Classification :
(20 SA)
.........----------10........20........30........--------40........50...-...-..-------------------------------------------60........70-........80........-----90-----........100.......110.......120.......130.......140.----..----....150.......160.......170-----.......180.......190.......200.......210...-....220--.....---------------...---------------230........240.......250------...--------......260.......270.......280.......290.......300.......310--.......320.......330.......340.......350.......360---..-----.......370.......380.......390.......400.......410.......420-..----------.......430.....-..440.......450.......460.....---..470.......480......------------------------------.490.....----..500.......510.-.......520.......530.......--540.......---550.......560.......570-.--......------580.......590.......600.......610.......620.......630.....--..640--.......650--......--.660--.......------------670.......680.--......690......-.700-....------.....710.......-720.......730.......740.......750.......760.......--770......--.780.......790...----------------..------------.-.800...--..-..810......-.820.......----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNSPRPTPP----------
P
F
A
A
A
AAG
L
P
I
L
V
R
ASNLVT
E
A
D
V
T
S
L
V
WN--------KAPCRFCGTG
C
S
V
M
V
-
A
TR-D
G
-------------------------------------------
Q
V
V
A
THG
D
I
K
A
E
-
V
N
RG
I
N
C
V
K
G
Y
F
L
S
K
I
MY-----GS-----
D
R
L
T
R
P
L
L
RMKDGKFDKQGEFQPI
S
W
E
Q
A
F
D
I
M
A
E
K
F
K
A
A
L
KAKGPESVGMF----GS----G
Q
W
T
V
WEGYA
A
N
K
L
F
K
A
GLRSNNIDP
N
-----
A
R
H
C
M
A
S
A
V
M
G
F
M
R
SFGMDEPMGCYDDIEATD
S
F
V
L
WGS
N
M
A
E
-
M
H
P
V
L
-
W
--
S
R
VTD---------------RRL---------------S-AP
Q
V
K
V
A
V
L
S
TFEHRSFELA--------DL
P
--------
M
V
FKPQT
D
L
I
I
L
N
Y
I
A
N
H
I
I
ESGAV
N
R
D
F
V
E
R
H
V
R
F
AHG
A
E
D
IGYGLRPDD
P
L
E
K
K
AKN--ADKANTWSDI
D
F
K
A
F
A
E
F
V
K
P
Y
T
L
E
R
T
A
RESGV
P
A
E
R
L
K
A
L
A
E
L
YADP-----
K
R
-----
K
V
V
S
F
W
TMGFNQHTRGVWAN
N
L
I
Y
N
I
H
L
L
T
GKISEPGNSP
F
S
LTGQPSACGT
A
R
E
V
G
T
---FS----------HRLPA
D
L
V
VTNP
K
H
R
-
E
T
A
E
K
I
WKVPA
G
T
I
Q
E
K
V
G
F
H
A
V
Q
Q
S
R
M
L
K---DG
V
L
N
V
Y
W
T
QVSNNMQA
G
P
N
V
------------------------------
M
Q
E
V
LPGWR----NPD
N
F
V
I
V
SDVYP-TV-SAQ
A
A
D
LILPS
A
M
W
V
EKEGAFG
N
A
E
R
R
--
T
Q
F
W
H
Q
L
V
KA---PG
E
A
K
S
D
L
W
Q
L
V
E
F
S
K
RFTTDEV-
W
--
P
A
E
L
L
A------KAPELKG
K
T
L
Y
D
V
L
FRNGQVDRF
P
A
S
D
L
A
K
GYANDE
V
D
A
F
G
F
Y
I
Q
K
G
L
F
E
E
Y
A
A
FGRG--HGHDL--A
P
F
D
A
Y
H
EAR--GLRWPV--VDGK--E
T
R
W
R
YR------------EGYDPYVSKGS
G
V
Q
--
F
YGYPDK
K
A
I
V
F
A
LP-YE---PPAE------APDQDY
P
F
W
L
AT
G
R
V
-
L
E
HWHTGSMT
A
R
V
P
E
L
Y
K
AVPD
A
L
V
Y
MHPE
D
A
R
Q
L
K
LRRGS
E
V
K
V
V
SRRG--
E
I
R
A
R
V
ETR--GRNKPPQ
G
L
V
F
V
P
FF
D
A
----------------
N
K
------------
L
-
I
N
K
V
TLD--AT-DPISKQT
D
Y
K
K
-
C
A
V
R
I
E
L
LNLA----------------
1
PsiBlast_PDB
97.91
73%
-68
- C1 -
3ML1
5
NAPA_CUPNH
A:
[4-799]
-------------------------------------
V
T
D
S
E
V
T
K
L
K
W
S
--------
K
A
P
C
R
F
C
G
T
G
C
G
V
T
V
-
A
V
K
-
D
N
-------------------------------------------
K
V
V
A
T
Q
G
D
P
Q
A
E
-
V
N
K
G
L
N
C
V
K
G
Y
F
L
S
K
I
M
Y
-----
G
Q
-----
D
R
L
T
R
P
L
M
R
M
K
N
G
K
Y
D
K
N
G
D
F
A
P
V
T
W
D
Q
A
F
D
E
M
E
R
Q
F
K
R
V
L
K
E
K
G
P
T
A
V
G
M
F
----
G
S
----
G
Q
W
T
V
W
E
G
Y
A
A
A
K
L
Y
K
A
G
F
R
S
N
N
I
D
P
N
-----
A
R
H
C
M
A
S
A
A
A
G
F
M
R
T
F
G
M
D
E
P
M
G
C
Y
D
D
F
E
A
A
D
A
F
V
L
W
G
S
N
M
A
E
-
M
H
P
I
L
-
W
--
T
R
V
T
D
---------------
R
R
L
---------------
S
-
H
P
K
T
R
V
V
V
L
S
T
F
T
H
R
C
F
D
L
A
--------
D
I
G
--------
I
I
F
K
P
Q
T
D
L
A
M
L
N
Y
I
A
N
Y
I
I
R
N
N
K
V
N
K
D
F
V
N
K
H
T
V
F
K
E
G
V
T
D
I
G
Y
G
L
R
P
D
H
P
L
Q
K
A
A
K
N
--
A
S
D
P
G
A
A
K
V
I
T
F
D
E
F
A
K
F
V
S
K
Y
D
A
D
Y
V
S
K
L
S
A
V
P
K
A
K
L
D
Q
L
A
E
L
Y
A
D
P
-----
N
I
-----
K
V
M
S
L
W
T
M
G
F
N
Q
H
T
R
G
T
W
A
N
N
M
V
Y
N
L
H
L
L
T
G
K
I
A
T
P
G
N
S
P
F
S
L
T
G
Q
P
S
A
C
G
T
A
R
E
V
G
T
---
F
S
----------
H
R
L
P
A
D
M
V
V
T
N
P
K
H
R
-
E
E
A
E
R
I
W
K
L
P
P
G
T
I
P
D
K
P
G
Y
D
A
V
L
Q
N
R
M
L
K
---
D
G
K
L
N
A
Y
W
V
Q
V
N
N
N
M
Q
A
A
A
N
L
------------------------------
M
E
E
G
L
P
G
Y
R
----
N
P
A
N
F
I
V
V
S
D
A
Y
P
-
T
V
-
T
A
L
A
A
D
L
V
L
P
S
A
M
W
V
E
K
E
G
A
Y
G
N
A
E
R
R
--
T
Q
F
W
H
Q
L
V
D
A
---
P
G
E
A
R
S
D
L
W
Q
L
V
E
F
A
K
R
F
K
V
E
E
V
-
W
--
P
P
E
L
I
A
------
K
K
P
E
Y
K
G
K
T
L
Y
D
V
L
Y
R
N
G
Q
V
D
K
F
P
L
K
D
V
N
A
E
Y
H
N
A
E
A
K
A
F
G
F
Y
L
Q
K
G
L
F
E
E
Y
A
T
F
G
R
G
--
H
G
H
D
L
--
A
P
F
D
A
Y
H
E
A
R
--
G
L
R
W
P
V
--
V
N
G
K
--
E
T
R
W
R
Y
R
------------
E
G
S
D
P
Y
V
K
A
G
T
G
F
Q
--
F
Y
G
N
P
D
G
K
A
V
I
F
A
L
P
-
Y
E
---
P
P
A
E
------
S
P
D
K
E
Y
P
Y
W
L
V
T
G
R
V
-
L
E
H
W
H
S
G
S
M
T
R
R
V
P
E
L
Y
R
S
F
P
N
A
V
V
F
M
H
P
E
D
A
K
A
L
G
L
R
R
G
V
E
V
E
V
V
S
R
R
G
--
R
M
R
S
R
I
E
T
R
--
G
R
D
A
P
P
R
G
L
V
F
V
P
W
F
D
A
----------------
S
Q
------------
L
-
I
N
K
V
T
L
D
--
A
T
-
C
P
I
S
L
Q
T
D
F
K
K
-
C
A
V
K
I
V
K
V
-------------------
38
HHSearch
96.86
72%
-66
- C1 -
3ML1
5
NAPA_CUPNH
A:
[4-802]
-------------------------------------
V
T
D
S
E
V
T
K
L
K
W
S
--------
K
A
P
C
R
F
C
G
T
G
C
G
V
T
V
-
A
V
K
-
D
N
-------------------------------------------
K
V
V
A
T
Q
G
D
P
Q
A
E
-
V
N
K
G
L
N
C
V
K
G
Y
F
L
S
K
I
M
Y
-----
G
Q
-----
D
R
L
T
R
P
L
M
R
M
K
N
G
K
Y
D
K
N
G
D
F
A
P
V
T
W
D
Q
A
F
D
E
M
E
R
Q
F
K
R
V
L
K
E
K
G
P
T
A
V
G
M
F
----
G
S
----
G
Q
W
T
V
W
E
G
Y
A
A
A
K
L
Y
K
A
G
F
R
S
N
N
I
D
P
N
-----
A
R
H
C
M
A
S
A
A
A
G
F
M
R
T
F
G
M
D
E
P
M
G
C
Y
D
D
F
E
A
A
D
A
F
V
L
W
G
S
N
M
A
E
-
M
H
P
I
L
-
W
--
T
R
V
T
D
---------------
R
R
L
---------------
S
H
P
-
K
T
R
V
V
V
L
S
T
F
T
H
R
C
F
D
L
A
--------
D
I
G
--------
I
I
F
K
P
Q
T
D
L
A
M
L
N
Y
I
A
N
Y
I
I
R
N
N
K
V
N
K
D
F
V
N
K
H
T
V
F
K
E
G
V
T
D
I
G
Y
G
L
R
P
D
H
P
L
Q
K
A
A
K
N
--
A
S
D
P
G
A
A
K
V
I
T
F
D
E
F
A
K
F
V
S
K
Y
D
A
D
Y
V
S
K
L
S
A
V
P
K
A
K
L
D
Q
L
A
E
L
Y
A
D
P
-----
N
I
-----
K
V
M
S
L
W
T
M
G
F
N
Q
H
T
R
G
T
W
A
N
N
M
V
Y
N
L
H
L
L
T
G
K
I
A
T
P
G
N
S
P
F
S
L
T
G
Q
P
S
A
C
G
T
A
R
E
V
G
T
---
F
S
----------
H
R
L
P
A
D
M
V
V
T
N
P
K
H
R
-
E
E
A
E
R
I
W
K
L
P
P
G
T
I
P
D
K
P
G
Y
D
A
V
L
Q
N
R
M
L
K
---
D
G
K
L
N
A
Y
W
V
Q
V
N
N
N
M
Q
A
A
A
N
--------------------------------
L
M
-
E
E
G
L
P
G
Y
R
N
P
A
-
N
F
I
V
V
S
D
A
Y
P
-
T
V
-
T
A
L
A
A
D
L
V
L
P
S
A
M
W
V
E
K
E
G
A
Y
G
N
A
E
R
R
--
T
Q
F
W
H
Q
L
V
D
A
---
P
G
E
A
R
S
D
L
W
Q
L
V
E
F
A
K
R
F
K
V
E
E
V
-
W
--
P
P
E
L
I
A
------
K
K
P
E
Y
K
G
K
T
L
Y
D
V
L
Y
R
N
G
Q
V
D
K
F
P
L
K
D
V
N
A
E
Y
H
N
A
E
A
K
A
F
G
F
Y
L
Q
K
G
L
F
E
E
Y
A
T
F
G
R
G
--
H
G
H
D
L
--
A
P
F
D
A
Y
H
E
A
R
--
G
L
R
W
P
V
--
V
N
G
K
--
E
T
R
W
R
Y
R
------------
E
G
S
D
P
Y
V
K
A
G
T
G
F
Q
--
F
Y
G
N
P
D
G
K
A
V
I
F
A
L
P
-
Y
E
---
P
P
A
E
------
S
P
D
K
E
Y
P
Y
W
L
V
T
G
R
V
-
L
E
H
W
H
S
G
S
M
T
R
R
V
P
E
L
Y
R
S
F
P
N
A
V
V
F
M
H
P
E
D
A
K
A
L
G
L
R
R
G
V
E
V
E
V
V
S
R
R
G
--
R
M
R
S
R
I
E
T
R
GR
D
A
P
P
R
--
G
L
V
F
V
P
W
F
D
A
----------------
S
Q
------------
L
-
I
N
K
V
T
L
D
--
A
T
-
C
P
I
S
L
Q
T
D
F
K
K
-
C
A
V
K
I
V
K
V
-------------------
21
PsiBlast_CBE
96.40
71%
-67
- C1 -
2NYA
4
NAPA_ECOLI
F:
[2-790]
--------------------------------------------
A
I
K
W
D
--------
K
A
P
C
R
F
C
G
T
G
C
G
V
L
V
-
G
T
Q
-
Q
G
-------------------------------------------
R
V
V
A
C
Q
G
D
P
D
A
P
-
V
N
R
G
L
N
C
I
K
G
Y
F
L
P
K
I
M
Y
-----
G
K
-----
D
R
L
T
Q
P
L
L
R
M
K
N
G
K
Y
D
K
E
G
E
F
T
P
I
T
W
D
Q
A
F
D
V
M
E
E
K
F
K
T
A
L
K
E
K
G
P
E
S
I
G
M
F
----
G
S
----
G
Q
W
T
I
W
E
G
Y
A
A
S
K
L
F
K
A
G
F
R
S
N
N
I
D
P
N
-----
A
R
H
C
M
A
S
A
V
V
G
F
M
R
T
F
G
M
D
E
P
M
G
C
Y
D
D
I
E
Q
A
D
A
F
V
L
W
G
A
N
M
A
E
-
M
H
P
I
L
-
W
--
S
R
I
T
N
---------------
R
R
L
---------------
S
-
N
Q
N
V
T
V
A
V
L
S
T
Y
Q
H
R
S
F
E
L
A
--------
D
N
G
--------
I
I
F
T
P
Q
S
D
L
V
I
L
N
Y
I
A
N
Y
I
I
Q
N
N
A
I
N
Q
D
F
F
S
K
H
V
N
L
R
K
G
A
T
D
I
G
Y
G
L
R
P
T
H
P
L
E
K
A
A
K
N
PG
S
D
A
S
E
P
M
S
F
E
D
Y
K
A
F
---
V
A
E
Y
T
L
E
K
T
A
E
M
T
G
V
P
K
D
Q
L
E
Q
L
A
Q
L
Y
A
D
P
-----
N
K
-----
K
V
I
S
Y
W
T
M
G
F
N
Q
H
T
R
G
V
W
A
N
N
L
V
Y
N
L
H
L
L
T
G
K
I
S
Q
P
G
C
G
P
F
S
L
T
G
Q
P
S
A
C
G
T
A
R
E
V
G
T
---
F
A
----------
H
R
L
P
A
D
M
V
V
T
N
E
K
H
R
-
D
I
C
E
K
K
W
N
I
P
S
G
T
I
P
A
K
I
G
L
H
A
V
A
Q
D
R
A
L
K
---
D
G
K
L
N
V
Y
W
T
M
C
T
N
N
M
Q
A
G
P
N
I
------------------------------
N
E
E
R
M
P
G
W
R
----
D
P
R
N
F
I
I
V
S
D
P
Y
P
-
T
V
-
S
A
L
A
A
D
L
I
L
P
T
A
M
W
V
E
K
E
G
A
Y
G
N
A
E
R
R
--
T
Q
F
W
R
Q
Q
V
Q
A
---
P
G
E
A
K
S
D
L
W
Q
L
V
Q
F
S
R
R
F
K
T
E
E
V
-
W
--
P
E
D
L
L
A
------
K
K
P
E
L
R
G
K
T
L
Y
E
V
L
Y
A
T
P
E
V
S
K
F
P
V
S
E
L
A
E
D
Q
L
N
D
E
S
R
E
L
G
F
Y
L
Q
K
G
L
F
E
E
Y
A
W
F
G
R
G
--
H
G
H
D
L
--
A
P
F
D
D
Y
H
K
A
R
--
G
L
R
W
P
V
--
V
N
G
K
--
E
T
Q
W
R
Y
S
------------
E
G
N
D
P
Y
V
K
A
G
E
G
Y
K
--
F
Y
G
K
P
D
G
K
A
V
I
F
A
L
P
-
F
E
---
P
A
A
E
------
A
P
D
E
E
Y
D
L
W
L
S
T
G
R
V
-
L
E
H
W
H
T
G
S
M
T
R
R
V
P
E
L
H
R
A
F
P
E
A
V
L
F
I
H
P
L
D
A
K
A
R
D
L
R
R
G
D
K
V
K
V
V
S
R
R
G
--
E
V
I
S
I
V
E
T
R
--
G
R
N
R
P
P
Q
G
L
V
Y
M
P
F
F
D
A
----------------
A
Q
------------
L
-
V
N
K
L
T
L
D
--
A
T
-
D
P
L
S
K
E
T
D
F
K
K
-
C
A
V
K
L
E
K
--------------------
2
PsiBlast_PDB
96.29
71%
-66
- C1 -
2NYA
4
NAPA_ECOLI
A:
[2-790]
--------------------------------------------
A
I
K
W
D
--------
K
A
P
C
R
F
C
G
T
G
C
G
V
L
V
-
G
T
Q
-
Q
G
-------------------------------------------
R
V
V
A
C
Q
G
D
P
D
A
P
-
V
N
R
G
L
N
C
I
K
G
Y
F
L
P
K
I
M
Y
-----
G
K
-----
D
R
L
T
Q
P
L
L
R
M
K
N
G
K
Y
D
K
E
G
E
F
T
P
I
T
W
D
Q
A
F
D
V
M
E
E
K
F
K
T
A
L
K
E
K
G
P
E
S
I
G
M
F
----
G
S
----
G
Q
W
T
I
W
E
G
Y
A
A
S
K
L
F
K
A
G
F
R
S
N
N
I
D
P
N
-----
A
R
H
C
M
A
S
A
V
V
G
F
M
R
T
F
G
M
D
E
P
M
G
C
Y
D
D
I
E
Q
A
D
A
F
V
L
W
G
A
N
M
A
E
-
M
H
P
I
L
-
W
--
S
R
I
T
N
---------------
R
R
L
---------------
S
-
N
Q
N
V
T
V
A
V
L
S
T
Y
Q
H
R
S
F
E
L
A
--------
D
N
G
--------
I
I
F
T
P
Q
S
D
L
V
I
L
N
Y
I
A
N
Y
I
I
Q
N
N
A
I
N
Q
D
F
F
S
K
H
V
N
L
R
K
G
A
T
D
I
G
Y
G
L
R
P
T
H
P
L
E
K
A
A
K
N
PG
S
D
A
S
E
P
M
S
F
E
D
Y
K
A
F
---
V
A
E
Y
T
L
E
K
T
A
E
M
T
G
V
P
K
D
Q
L
E
Q
L
A
Q
L
Y
A
D
P
-----
N
K
-----
K
V
I
S
Y
W
T
M
G
F
N
Q
H
T
R
G
V
W
A
N
N
L
V
Y
N
L
H
L
L
T
G
K
I
S
Q
P
G
C
G
P
F
S
L
T
G
Q
P
S
A
C
G
T
A
R
E
V
G
T
---
F
A
----------
H
R
L
P
A
D
M
V
V
T
N
E
K
H
R
-
D
I
C
E
K
K
W
N
I
P
S
G
T
I
P
A
K
I
G
L
H
A
V
A
Q
D
R
A
L
K
---
D
G
K
L
N
V
Y
W
T
M
C
T
N
N
M
Q
A
G
P
N
I
------------------------------
N
E
E
R
M
P
G
W
R
----
D
P
R
N
F
I
I
V
S
D
P
Y
P
-
T
V
-
S
A
L
A
A
D
L
I
L
P
T
A
M
W
V
E
K
E
G
A
Y
G
N
A
E
R
R
--
T
Q
F
W
R
Q
Q
V
Q
A
---
P
G
E
A
K
S
D
L
W
Q
L
V
Q
F
S
R
R
F
K
T
E
E
V
-
W
--
P
E
D
L
L
A
------
K
K
P
E
L
R
G
K
T
L
Y
E
V
L
Y
A
T
P
E
V
S
K
F
P
V
S
E
L
A
E
D
Q
L
N
D
E
S
R
E
L
G
F
Y
L
Q
K
G
L
F
E
E
Y
A
W
F
G
R
G
--
H
G
H
D
L
--
A
P
F
D
D
Y
H
K
A
R
--
G
L
R
W
P
V
--
V
N
G
K
--
E
T
Q
W
R
Y
S
------------
E
G
N
D
P
Y
V
K
A
G
E
G
Y
K
--
F
Y
G
K
P
D
G
K
A
V
I
F
A
L
P
-
F
E
---
P
A
A
E
------
A
P
D
E
E
Y
D
L
W
L
S
T
G
R
V
-
L
E
H
W
H
T
G
S
M
T
R
R
V
P
E
L
H
R
A
F
P
E
A
V
L
F
I
H
P
L
D
A
K
A
R
D
L
R
R
G
D
K
V
K
V
V
S
R
R
G
--
E
V
I
S
I
V
E
T
R
--
G
R
N
R
P
P
Q
G
L
V
Y
M
P
F
F
D
A
----------------
A
Q
------------
L
-
V
N
K
L
T
L
D
--
A
T
-
D
P
L
S
K
E
T
D
F
K
K
-
C
A
V
K
L
E
K
--------------------
3
PsiBlast_PDB
96.19
71%
-67
- C1 -
1OGY
5
NAPA_RHOS4
A:
[12-800]
---------------------------------------------
I
R
W
S
--------
K
A
P
C
R
F
C
G
T
G
C
G
V
M
V
-
G
T
R
-
D
G
-------------------------------------------
Q
V
V
A
T
H
G
D
T
Q
A
E
-
V
N
R
G
L
N
C
V
K
G
Y
F
L
S
K
I
M
Y
-----
G
E
-----
D
R
L
T
T
P
L
L
R
M
K
D
G
V
Y
H
K
E
G
E
F
A
P
V
S
W
D
E
A
F
D
V
M
A
A
Q
A
K
L
V
L
K
E
K
A
P
E
A
V
G
M
F
----
G
S
----
G
Q
W
T
I
W
E
G
Y
A
A
S
K
L
M
R
A
G
F
R
S
N
N
L
D
P
N
-----
A
R
H
C
M
A
S
A
A
T
A
F
M
R
T
F
G
M
D
E
P
M
G
C
Y
D
D
F
E
A
A
D
A
F
V
L
W
G
S
N
M
A
E
-
M
H
P
I
L
-
W
--
S
R
L
T
D
---------------
R
R
L
---------------
S
-
H
E
H
V
R
V
A
V
L
S
T
F
T
H
R
S
S
D
L
S
--------
D
T
P
--------
I
I
F
R
P
G
T
D
R
A
I
L
N
Y
I
A
H
H
I
I
S
T
G
R
V
N
R
D
F
V
D
R
H
T
N
F
A
L
G
A
T
D
I
G
Y
G
L
R
P
E
H
Q
L
Q
L
A
A
K
G
--
A
A
D
A
G
A
M
T
P
T
D
F
E
T
F
A
A
L
V
S
E
Y
T
L
E
K
A
A
E
I
S
G
V
E
P
A
L
L
E
E
L
A
E
L
Y
A
D
P
-----
D
R
-----
K
W
M
S
L
W
T
M
G
F
N
Q
H
V
R
G
V
W
A
N
H
M
V
Y
N
L
H
L
L
T
G
K
I
S
E
P
G
N
S
P
F
S
L
T
G
Q
P
F
A
C
G
T
A
R
E
V
G
T
---
F
A
----------
H
R
L
P
A
D
M
V
V
T
N
P
E
H
R
-
A
H
A
E
E
I
W
K
L
P
A
G
L
L
P
D
W
V
G
A
H
A
V
E
Q
D
R
K
L
H
---
D
G
E
I
N
F
Y
W
V
Q
V
N
N
N
M
Q
A
A
P
N
I
------------------------------
D
Q
E
T
Y
P
G
Y
R
----
N
P
E
N
F
I
V
V
S
D
A
Y
P
-
T
V
-
T
G
R
A
A
D
L
V
L
P
A
A
M
W
V
E
K
E
G
A
Y
G
N
A
E
R
R
--
T
H
F
W
H
Q
L
V
E
A
---
P
G
E
A
R
S
D
L
W
Q
L
M
E
F
S
K
R
F
T
T
D
E
V
-
W
--
P
E
E
I
L
S
------
A
A
P
A
Y
R
G
K
T
L
F
E
V
L
F
A
N
G
S
V
D
R
F
P
A
S
D
V
N
P
D
H
A
N
H
E
A
A
L
F
G
F
Y
P
Q
K
G
L
F
E
E
Y
A
A
F
G
R
G
--
H
G
H
D
L
--
A
P
F
D
T
Y
H
E
V
R
--
G
L
H
W
P
V
--
V
E
G
E
--
E
T
R
W
R
Y
R
------------
E
G
F
D
P
Y
V
K
P
G
E
G
L
R
--
F
Y
G
K
P
D
G
R
A
V
I
L
G
V
P
-
Y
E
---
P
P
A
E
------
S
P
D
E
E
F
G
F
W
L
V
T
G
R
V
-
L
E
H
W
H
S
G
S
M
T
L
R
W
P
E
L
Y
K
A
F
P
G
A
V
C
F
M
H
P
E
D
A
R
S
R
G
L
N
R
G
S
E
V
R
V
I
S
R
R
G
--
E
I
R
T
R
L
E
T
R
--
G
R
N
R
M
P
R
G
V
V
F
V
P
W
F
D
A
----------------
S
Q
------------
L
-
I
N
K
V
T
L
D
--
A
N
-
D
P
I
S
R
Q
T
D
F
K
K
-
C
A
V
K
I
E
A
--------------------
28
PsiBlast_CBE
95.62
71%
-67
- C1 -
1OGY
4
NAPA_RHOS4
C:
[12-800]
---------------------------------------------
I
R
W
S
--------
K
A
P
C
R
F
C
G
T
G
C
G
V
M
V
-
G
T
R
-
D
G
-------------------------------------------
Q
V
V
A
T
H
G
D
T
Q
A
E
-
V
N
R
G
L
N
C
V
K
G
Y
F
L
S
K
I
M
Y
-----
G
E
-----
D
R
L
T
T
P
L
L
R
M
K
D
G
V
Y
H
K
E
G
E
F
A
P
V
S
W
D
E
A
F
D
V
M
A
A
Q
A
K
L
V
L
K
E
K
A
P
E
A
V
G
M
F
----
G
S
----
G
Q
W
T
I
W
E
G
Y
A
A
S
K
L
M
R
A
G
F
R
S
N
N
L
D
P
N
-----
A
R
H
C
M
A
S
A
A
T
A
F
M
R
T
F
G
M
D
E
P
M
G
C
Y
D
D
F
E
A
A
D
A
F
V
L
W
G
S
N
M
A
E
-
M
H
P
I
L
-
W
--
S
R
L
T
D
---------------
R
R
L
---------------
S
-
H
E
H
V
R
V
A
V
L
S
T
F
T
H
R
S
S
D
L
S
--------
D
T
P
--------
I
I
F
R
P
G
T
D
R
A
I
L
N
Y
I
A
H
H
I
I
S
T
G
R
V
N
R
D
F
V
D
R
H
T
N
F
A
L
G
A
T
D
I
G
Y
G
L
R
P
E
H
Q
L
Q
L
A
A
K
G
--
A
A
D
A
G
A
M
T
P
T
D
F
E
T
F
A
A
L
V
S
E
Y
T
L
E
K
A
A
E
I
S
G
V
E
P
A
L
L
E
E
L
A
E
L
Y
A
D
P
-----
D
R
-----
K
W
M
S
L
W
T
M
G
F
N
Q
H
V
R
G
V
W
A
N
H
M
V
Y
N
L
H
L
L
T
G
K
I
S
E
P
G
N
S
P
F
S
L
T
G
Q
P
F
A
C
G
T
A
R
E
V
G
T
---
F
A
----------
H
R
L
P
A
D
M
V
V
T
N
P
E
H
R
-
A
H
A
E
E
I
W
K
L
P
A
G
L
L
P
D
W
V
G
A
H
A
V
E
Q
D
R
K
L
H
---
D
G
E
I
N
F
Y
W
V
Q
V
N
N
N
M
Q
A
A
P
N
I
------------------------------
D
Q
E
T
Y
P
G
Y
R
----
N
P
E
N
F
I
V
V
S
D
A
Y
P
-
T
V
-
T
G
R
A
A
D
L
V
L
P
A
A
M
W
V
E
K
E
G
A
Y
G
N
A
E
R
R
--
T
H
F
W
H
Q
L
V
E
A
---
P
G
E
A
R
S
D
L
W
Q
L
M
E
F
S
K
R
F
T
T
D
E
V
-
W
--
P
E
E
I
L
S
------
A
A
P
A
Y
R
G
K
T
L
F
E
V
L
F
A
N
G
S
V
D
R
F
P
A
S
D
V
N
P
D
H
A
N
H
E
A
A
L
F
G
F
Y
P
Q
K
G
L
F
E
E
Y
A
A
F
G
R
G
--
H
G
H
D
L
--
A
P
F
D
T
Y
H
E
V
R
--
G
L
H
W
P
V
--
V
E
G
E
--
E
T
R
W
R
Y
R
------------
E
G
F
D
P
Y
V
K
P
G
E
G
L
R
--
F
Y
G
K
P
D
G
R
A
V
I
L
G
V
P
-
Y
E
---
P
P
A
E
------
S
P
D
E
E
F
G
F
W
L
V
T
G
R
V
-
L
E
H
W
H
S
G
S
M
T
L
R
W
P
E
L
Y
K
A
F
P
G
A
V
C
F
M
H
P
E
D
A
R
S
R
G
L
N
R
G
S
E
V
R
V
I
S
R
R
G
--
E
I
R
T
R
L
E
T
R
--
G
R
N
R
M
P
R
G
V
V
F
V
P
W
F
D
A
----------------
S
Q
------------
L
-
I
N
K
V
T
L
D
--
A
N
-
D
P
I
S
R
Q
T
D
F
K
K
-
C
A
V
K
I
E
A
--------------------
22
PsiBlast_CBE
95.51
71%
-67
- C1 -
1OGY
25
NAPA_RHOS4
O:
[12-800]
---------------------------------------------
I
R
W
S
--------
K
A
P
C
R
F
C
G
T
G
C
G
V
M
V
-
G
T
R
-
D
G
-------------------------------------------
Q
V
V
A
T
H
G
D
T
Q
A
E
-
V
N
R
G
L
N
C
V
K
G
Y
F
L
S
K
I
M
Y
-----
G
E
-----
D
R
L
T
T
P
L
L
R
M
K
D
G
V
Y
H
K
E
G
E
F
A
P
V
S
W
D
E
A
F
D
V
M
A
A
Q
A
K
L
V
L
K
E
K
A
P
E
A
V
G
M
F
----
G
S
----
G
Q
W
T
I
W
E
G
Y
A
A
S
K
L
M
R
A
G
F
R
S
N
N
L
D
P
N
-----
A
R
H
C
M
A
S
A
A
T
A
F
M
R
T
F
G
M
D
E
P
M
G
C
Y
D
D
F
E
A
A
D
A
F
V
L
W
G
S
N
M
A
E
-
M
H
P
I
L
-
W
--
S
R
L
T
D
---------------
R
R
L
---------------
S
-
H
E
H
V
R
V
A
V
L
S
T
F
T
H
R
S
S
D
L
S
--------
D
T
P
--------
I
I
F
R
P
G
T
D
R
A
I
L
N
Y
I
A
H
H
I
I
S
T
G
R
V
N
R
D
F
V
D
R
H
T
N
F
A
L
G
A
T
D
I
G
Y
G
L
R
P
E
H
Q
L
Q
L
A
A
K
G
--
A
A
D
A
G
A
M
T
P
T
D
F
E
T
F
A
A
L
V
S
E
Y
T
L
E
K
A
A
E
I
S
G
V
E
P
A
L
L
E
E
L
A
E
L
Y
A
D
P
-----
D
R
-----
K
W
M
S
L
W
T
M
G
F
N
Q
H
V
R
G
V
W
A
N
H
M
V
Y
N
L
H
L
L
T
G
K
I
S
E
P
G
N
S
P
F
S
L
T
G
Q
P
F
A
C
G
T
A
R
E
V
G
T
---
F
A
----------
H
R
L
P
A
D
M
V
V
T
N
P
E
H
R
-
A
H
A
E
E
I
W
K
L
P
A
G
L
L
P
D
W
V
G
A
H
A
V
E
Q
D
R
K
L
H
---
D
G
E
I
N
F
Y
W
V
Q
V
N
N
N
M
Q
A
A
P
N
I
------------------------------
D
Q
E
T
Y
P
G
Y
R
----
N
P
E
N
F
I
V
V
S
D
A
Y
P
-
T
V
-
T
G
R
A
A
D
L
V
L
P
A
A
M
W
V
E
K
E
G
A
Y
G
N
A
E
R
R
--
T
H
F
W
H
Q
L
V
E
A
---
P
G
E
A
R
S
D
L
W
Q
L
M
E
F
S
K
R
F
T
T
D
E
V
-
W
--
P
E
E
I
L
S
------
A
A
P
A
Y
R
G
K
T
L
F
E
V
L
F
A
N
G
S
V
D
R
F
P
A
S
D
V
N
P
D
H
A
N
H
E
A
A
L
F
G
F
Y
P
Q
K
G
L
F
E
E
Y
A
A
F
G
R
G
--
H
G
H
D
L
--
A
P
F
D
T
Y
H
E
V
R
--
G
L
H
W
P
V
--
V
E
G
E
--
E
T
R
W
R
Y
R
------------
E
G
F
D
P
Y
V
K
P
G
E
G
L
R
--
F
Y
G
K
P
D
G
R
A
V
I
L
G
V
P
-
Y
E
---
P
P
A
E
------
S
P
D
E
E
F
G
F
W
L
V
T
G
R
V
-
L
E
H
W
H
S
G
S
M
T
L
R
W
P
E
L
Y
K
A
F
P
G
A
V
C
F
M
H
P
E
D
A
R
S
R
G
L
N
R
G
S
E
V
R
V
I
S
R
R
G
--
E
I
R
T
R
L
E
T
R
--
G
R
N
R
M
P
R
G
V
V
F
V
P
W
F
D
A
----------------
S
Q
------------
L
-
I
N
K
V
T
L
D
--
A
N
-
D
P
I
S
R
Q
T
D
F
K
K
-
C
A
V
K
I
E
A
--------------------
11
PsiBlast_PDB
80.00
36%
-63
- C1 -
2V45
6
NAPA_DESDA
A:
[8-720]
-----------------------------------------------
W
V
--------
K
G
V
C
R
Y
C
G
T
G
C
G
V
L
V
-
G
V
K
-
D
G
-------------------------------------------
K
A
V
A
I
Q
G
N
P
N
N
H
--
N
A
G
L
L
C
L
K
G
S
L
L
I
P
V
L
N
-----
S
K
-----
E
R
V
T
Q
P
L
V
R
R
H
K
G
-----
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
----
G
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
P
V
L
-
F
--
R
R
I
A
R
---------------
R
K
Q
---------------
V
-
E
P
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
M
H
--------
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
E
L
D
N
P
R
F
W
Q
R
Y
V
N
F
----------------
M
D
A
E
G
K
P
--
S
---------
D
F
E
G
Y
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
A
E
------
S
A
-----
A
T
M
S
L
W
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
T
S
F
S
L
T
G
Q
P
N
A
C
G
G
V
R
D
G
G
A
---
L
S
----------
H
L
L
P
A
G
R
A
I
P
N
A
K
H
R
-
A
E
M
E
K
L
W
G
L
P
E
G
R
I
A
P
E
P
G
Y
H
T
V
A
L
F
E
A
L
G
---
R
G
D
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
-------------------------------
L
N
K
V
H
K
A
M
S
----
H
P
E
S
F
I
V
C
I
E
A
F
P
D
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
E
R
R
--
Y
S
L
T
E
K
A
V
D
P
---
P
G
Q
C
R
P
T
V
N
T
L
V
E
F
A
R
R
A
G
V
D
--------------------
P
Q
L
-------
V
N
F
R
N
A
E
---------------------------
D
V
W
N
E
W
R
M
V
S
K
G
--
T
T
Y
D
F
WG
M
T
R
E
R
L
R
K
E
S
--
G
L
I
W
P
C
PS
E
D
H
P
--
G
T
S
L
R
Y
V
------------
R
G
Q
D
P
C
V
P
A
D
H
P
D
R
FF
F
Y
G
K
P
D
G
R
A
V
I
W
M
R
P
-
A
K
---
G
A
A
E
------
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
A
M
E
L
P
A
R
V
S
D
V
--
C
R
----
P
G
L
I
A
V
P
F
F
D
P
----------------
K
K
------------
L
-
V
N
K
L
F
L
D
--
A
T
-
D
P
V
S
R
E
P
E
Y
K
I
-
C
A
A
R
V
R
K
A
-------------------
6
PsiBlast_PDB
79.83
36%
-64
- C1 -
2V3V
9
NAPA_DESDA
A:
[8-720]
-----------------------------------------------
W
V
--------
K
G
V
C
R
Y
C
G
T
G
C
G
V
L
V
-
G
V
K
-
D
G
-------------------------------------------
K
A
V
A
I
Q
G
D
P
N
N
H
--
N
A
G
L
L
C
L
K
G
S
L
L
I
P
V
L
N
-----
S
K
-----
E
R
V
T
Q
P
L
V
R
R
H
K
G
-----
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
----
G
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
P
V
L
-
F
--
R
R
I
A
R
---------------
R
K
Q
---------------
V
-
E
P
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
M
H
--------
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
E
L
D
N
P
R
F
W
Q
R
Y
V
N
F
----------------
M
D
A
E
G
K
P
--
S
---------
D
F
E
G
Y
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
A
E
------
S
A
-----
A
T
M
S
L
W
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
T
S
F
S
L
T
G
Q
P
N
A
C
G
G
V
R
D
G
G
A
---
L
S
----------
H
L
L
P
A
G
R
A
I
P
N
A
K
H
R
-
A
E
M
E
K
L
W
G
L
P
E
G
R
I
A
P
E
P
G
Y
H
T
V
A
L
F
E
A
L
G
---
R
G
D
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
-------------------------------
L
N
K
V
H
K
A
M
S
----
H
P
E
S
F
I
V
C
I
E
A
F
P
D
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
E
R
R
--
Y
S
L
T
E
K
A
V
D
P
---
P
G
Q
C
R
P
T
V
N
T
L
V
E
F
A
R
R
A
G
V
D
--------------------
P
Q
L
-------
V
N
F
R
N
A
E
---------------------------
D
V
W
N
E
W
R
M
V
S
K
G
--
T
T
Y
D
F
WG
M
T
R
E
R
L
R
K
E
S
--
G
L
I
W
P
C
PS
E
D
H
P
--
G
T
S
L
R
Y
V
------------
R
G
Q
D
P
C
V
P
A
D
H
P
D
R
FF
F
Y
G
K
P
D
G
R
A
V
I
W
M
R
P
-
A
K
---
G
A
A
E
------
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
A
M
E
L
P
A
R
V
S
D
V
--
C
R
----
P
G
L
I
A
V
P
F
F
D
P
----------------
K
K
------------
L
-
V
N
K
L
F
L
D
--
A
T
-
D
P
V
S
R
E
P
E
Y
K
I
-
C
A
A
R
V
R
K
A
-------------------
8
PsiBlast_PDB
79.65
36%
-62
- C1 -
2JIM
5
NAPA_DESDA
A:
[8-720]
-----------------------------------------------
W
V
--------
K
G
V
C
R
Y
C
G
T
G
C
G
V
L
V
-
G
V
K
-
D
G
-------------------------------------------
K
A
V
A
I
Q
G
N
P
N
N
H
--
N
A
G
L
L
C
L
K
G
S
L
L
I
P
V
L
N
-----
S
K
-----
E
R
V
T
Q
P
L
V
R
R
H
K
G
-----
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
----
G
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
P
V
L
-
F
--
R
R
I
A
R
---------------
R
K
Q
---------------
V
-
E
P
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
M
H
--------
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
E
L
D
N
P
R
F
W
Q
R
Y
V
N
F
----------------
M
D
A
E
G
K
P
--
S
---------
D
F
E
G
Y
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
A
E
------
S
A
-----
A
T
M
S
L
W
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
T
S
F
S
L
T
G
Q
P
N
A
C
G
G
V
R
D
G
G
A
---
L
S
----------
H
L
L
P
A
G
R
A
I
P
N
A
K
H
R
-
A
E
M
E
K
L
W
G
L
P
E
G
R
I
A
P
E
P
G
Y
H
T
V
A
L
F
E
A
L
G
---
R
G
D
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
-------------------------------
L
N
K
V
H
K
A
M
S
----
H
P
E
S
F
I
V
C
I
E
A
F
P
D
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
E
R
R
--
Y
S
L
T
E
K
A
V
D
P
---
P
G
Q
C
R
P
T
V
N
T
L
V
E
F
A
R
R
A
G
V
D
--------------------
P
Q
L
-------
V
N
F
R
N
A
E
---------------------------
D
V
W
N
E
W
R
M
V
S
K
G
--
T
T
Y
D
F
WG
M
T
R
E
R
L
R
K
E
S
--
G
L
I
W
P
C
PS
E
D
H
P
--
G
T
S
L
R
Y
V
------------
R
G
Q
D
P
C
V
P
A
D
H
P
D
R
FF
F
Y
G
K
P
D
G
R
A
V
I
W
M
R
P
-
A
K
---
G
A
A
E
------
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
A
M
E
L
P
A
R
V
S
D
V
--
C
R
----
P
G
L
I
A
V
P
F
F
D
P
----------------
K
K
------------
L
-
V
N
K
L
F
L
D
--
A
T
-
D
P
V
S
R
E
P
E
Y
K
I
-
C
A
A
R
V
R
K
A
-------------------
4
PsiBlast_PDB
79.64
36%
-64
- C1 -
2JIO
5
NAPA_DESDA
A:
[8-720]
-----------------------------------------------
W
V
--------
K
G
V
C
R
Y
C
G
T
G
C
G
V
L
V
-
G
V
K
-
D
G
-------------------------------------------
K
A
V
A
I
Q
G
D
P
N
N
H
--
N
A
G
L
L
C
L
K
G
S
L
L
I
P
V
L
N
-----
S
K
-----
E
R
V
T
Q
P
L
V
R
R
H
K
G
-----
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
----
G
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
P
V
L
-
F
--
R
R
I
A
R
---------------
R
K
Q
---------------
V
-
E
P
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
M
H
--------
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
E
L
D
N
P
R
F
W
Q
R
Y
V
N
F
----------------
M
D
A
E
G
K
P
--
S
---------
D
F
E
G
Y
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
A
E
------
S
A
-----
A
T
M
S
L
W
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
T
S
F
S
L
T
G
Q
P
N
A
C
G
G
V
R
D
G
G
A
---
L
S
----------
H
L
L
P
A
G
R
A
I
P
N
A
K
H
R
-
A
E
M
E
K
L
W
G
L
P
E
G
R
I
A
P
E
P
G
Y
H
T
V
A
L
F
E
A
L
G
---
R
G
D
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
-------------------------------
L
N
K
V
H
K
A
M
S
----
H
P
E
S
F
I
V
C
I
E
A
F
P
D
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
E
R
R
--
Y
S
L
T
E
K
A
V
D
P
---
P
G
Q
C
R
P
T
V
N
T
L
V
E
F
A
R
R
A
G
V
D
--------------------
P
Q
L
-------
V
N
F
R
N
A
E
---------------------------
D
V
W
N
E
W
R
M
V
S
K
G
--
T
T
Y
D
F
WG
M
T
R
E
R
L
R
K
E
S
--
G
L
I
W
P
C
PS
E
D
H
P
--
G
T
S
L
R
Y
V
------------
R
G
Q
D
P
C
V
P
A
D
H
P
D
R
FF
F
Y
G
K
P
D
G
R
A
V
I
W
M
R
P
-
A
K
---
G
A
A
E
------
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
A
M
E
L
P
A
R
V
S
D
V
--
C
R
----
P
G
L
I
A
V
P
F
F
D
P
----------------
K
K
------------
L
-
V
N
K
L
F
L
D
--
A
T
-
D
P
V
S
R
E
P
E
Y
K
I
-
C
A
A
R
V
R
K
A
-------------------
10
PsiBlast_PDB
79.61
36%
-63
- C1 -
2JIR
6
NAPA_DESDA
A:
[8-720]
-----------------------------------------------
W
V
--------
K
G
V
C
R
Y
C
G
T
G
C
G
V
L
V
-
G
V
K
-
D
G
-------------------------------------------
K
A
V
A
I
Q
G
N
P
N
N
H
--
N
A
G
L
L
C
L
K
G
S
L
L
I
P
V
L
N
-----
S
K
-----
E
R
V
T
Q
P
L
V
R
R
H
K
G
-----
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
----
G
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
P
V
L
-
F
--
R
R
I
A
R
---------------
R
K
Q
---------------
V
-
E
P
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
M
H
--------
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
E
L
D
N
P
R
F
W
Q
R
Y
V
N
F
----------------
M
D
A
E
G
K
P
--
S
---------
D
F
E
G
Y
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
A
E
------
S
A
-----
A
T
M
S
L
W
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
T
S
F
S
L
T
G
Q
P
N
A
C
G
G
V
R
D
G
G
A
---
L
S
----------
H
L
L
P
A
G
R
A
I
P
N
A
K
H
R
-
A
E
M
E
K
L
W
G
L
P
E
G
R
I
A
P
E
P
G
Y
H
T
V
A
L
F
E
A
L
G
---
R
G
D
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
-------------------------------
L
N
K
V
H
K
A
M
S
----
H
P
E
S
F
I
V
C
I
E
A
F
P
D
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
E
R
R
--
Y
S
L
T
E
K
A
V
D
P
---
P
G
Q
C
R
P
T
V
N
T
L
V
E
F
A
R
R
A
G
V
D
--------------------
P
Q
L
-------
V
N
F
R
N
A
E
---------------------------
D
V
W
N
E
W
R
M
V
S
K
G
--
T
T
Y
D
F
WG
M
T
R
E
R
L
R
K
E
S
--
G
L
I
W
P
C
PS
E
D
H
P
--
G
T
S
L
R
Y
V
------------
R
G
Q
D
P
C
V
P
A
D
H
P
D
R
FF
F
Y
G
K
P
D
G
R
A
V
I
W
M
R
P
-
A
K
---
G
A
A
E
------
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
A
M
E
L
P
A
R
V
S
D
V
--
C
R
----
P
G
L
I
A
V
P
F
F
D
P
----------------
K
K
------------
L
-
V
N
K
L
F
L
D
--
A
T
-
D
P
V
S
R
E
P
E
Y
K
I
-
C
A
A
R
V
R
K
A
-------------------
7
PsiBlast_PDB
79.51
36%
-64
- C1 -
2NAP
5
NAPA_DESDA
A:
[8-720]
-----------------------------------------------
W
V
--------
K
G
V
C
R
Y
C
G
T
G
C
G
V
L
V
-
G
V
K
-
D
G
-------------------------------------------
K
A
V
A
I
Q
G
N
P
N
N
H
--
N
A
G
L
L
C
L
K
G
S
L
L
I
P
V
L
N
-----
S
K
-----
E
R
V
T
Q
P
L
V
R
R
H
K
G
-----
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
----
G
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
P
V
L
-
F
--
R
R
I
A
R
---------------
R
K
Q
---------------
V
-
E
P
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
M
H
--------
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
E
L
D
N
P
R
F
W
Q
R
Y
V
N
F
----------------
M
D
A
E
G
K
P
--
S
---------
D
F
E
G
Y
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
A
E
------
S
A
-----
A
T
M
S
L
W
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
T
S
F
S
L
T
G
Q
P
N
A
C
G
G
V
R
D
G
G
A
---
L
S
----------
H
L
L
P
A
G
R
A
I
P
N
A
K
H
R
-
A
E
M
E
K
L
W
G
L
P
E
G
R
I
A
P
E
P
G
Y
H
T
V
A
L
F
E
A
L
G
---
R
G
D
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
-------------------------------
L
N
K
V
H
K
A
M
S
----
H
P
E
S
F
I
V
C
I
E
A
F
P
D
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
E
R
R
--
Y
S
L
T
E
K
A
V
D
P
---
P
G
Q
C
R
P
T
V
N
T
L
V
E
F
A
R
R
A
G
V
D
--------------------
P
Q
L
-------
V
N
F
R
N
A
E
---------------------------
D
V
W
N
E
W
R
M
V
S
K
G
--
T
T
Y
D
F
WG
M
T
R
E
R
L
R
K
E
S
--
G
L
I
W
P
C
PS
E
D
H
P
--
G
T
S
L
R
Y
V
------------
R
G
Q
D
P
C
V
P
A
D
H
P
D
R
FF
F
Y
G
K
P
D
G
R
A
V
I
W
M
R
P
-
A
K
---
G
A
A
E
------
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
A
M
E
L
P
A
R
V
S
D
V
--
C
R
----
P
G
L
I
A
V
P
F
F
D
P
----------------
K
K
------------
L
-
V
N
K
L
F
L
D
--
A
T
-
D
P
V
S
R
E
P
E
Y
K
I
-
C
A
A
R
V
R
K
A
-------------------
5
PsiBlast_PDB
79.49
36%
-63
- C1 -
2JIQ
12
NAPA_DESDA
A:
[8-720]
-----------------------------------------------
W
V
--------
K
G
V
C
R
Y
C
G
T
G
C
G
V
L
V
-
G
V
K
-
D
G
-------------------------------------------
K
A
V
A
I
Q
G
D
P
N
N
H
--
N
A
G
L
L
C
L
K
G
S
L
L
I
P
V
L
N
-----
S
K
-----
E
R
V
T
Q
P
L
V
R
R
H
K
G
-----
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
----
G
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
P
V
L
-
F
--
R
R
I
A
R
---------------
R
K
Q
---------------
V
-
E
P
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
M
H
--------
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
E
L
D
N
P
R
F
W
Q
R
Y
V
N
F
----------------
M
D
A
E
G
K
P
--
S
---------
D
F
E
G
Y
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
A
E
------
S
A
-----
A
T
M
S
L
W
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
T
S
F
S
L
T
G
Q
P
N
A
C
G
G
V
R
D
G
G
A
---
L
S
----------
H
L
L
P
A
G
R
A
I
P
N
A
K
H
R
-
A
E
M
E
K
L
W
G
L
P
E
G
R
I
A
P
E
P
G
Y
H
T
V
A
L
F
E
A
L
G
---
R
G
D
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
-------------------------------
L
N
K
V
H
K
A
M
S
----
H
P
E
S
F
I
V
C
I
E
A
F
P
D
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
E
R
R
--
Y
S
L
T
E
K
A
V
D
P
---
P
G
Q
C
R
P
T
V
N
T
L
V
E
F
A
R
R
A
G
V
D
--------------------
P
Q
L
-------
V
N
F
R
N
A
E
---------------------------
D
V
W
N
E
W
R
M
V
S
K
G
--
T
T
Y
D
F
WG
M
T
R
E
R
L
R
K
E
S
--
G
L
I
W
P
C
PS
E
D
H
P
--
G
T
S
L
R
Y
V
------------
R
G
Q
D
P
C
V
P
A
D
H
P
D
R
FF
F
Y
G
K
P
D
G
R
A
V
I
W
M
R
P
-
A
K
---
G
A
A
E
------
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
A
M
E
L
P
A
R
V
S
D
V
--
C
R
----
P
G
L
I
A
V
P
F
F
D
P
----------------
K
K
------------
L
-
V
N
K
L
F
L
D
--
A
T
-
D
P
V
S
R
E
P
E
Y
K
I
-
C
A
A
R
V
R
K
A
-------------------
9
PsiBlast_PDB
79.33
36%
-64
- C1 -
2JIP
5
NAPA_DESDA
A:
[8-720]
-----------------------------------------------
W
V
--------
K
G
V
C
R
Y
C
G
T
G
C
G
V
L
V
-
G
V
K
-
D
G
-------------------------------------------
K
A
V
A
I
Q
G
N
P
N
N
H
--
N
A
G
L
L
C
L
K
G
S
L
L
I
P
V
L
N
-----
S
K
-----
E
R
V
T
Q
P
L
V
R
R
H
K
G
-----
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
----
G
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
P
V
L
-
F
--
R
R
I
A
R
---------------
R
K
Q
---------------
V
-
E
P
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
M
H
--------
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
E
L
D
N
P
R
F
W
Q
R
Y
V
N
F
----------------
M
D
A
E
G
K
P
--
S
---------
D
F
E
G
Y
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
A
E
------
S
A
-----
A
T
M
S
L
W
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
T
S
F
S
L
T
G
Q
P
N
A
C
G
G
V
R
D
G
G
A
---
L
S
----------
H
L
L
P
A
G
R
A
I
P
N
A
K
H
R
-
A
E
M
E
K
L
W
G
L
P
E
G
R
I
A
P
E
P
G
Y
H
T
V
A
L
F
E
A
L
G
---
R
G
D
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
-------------------------------
L
N
K
V
H
K
A
M
S
----
H
P
E
S
F
I
V
C
I
E
A
F
P
D
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
E
R
R
--
Y
S
L
T
E
K
A
V
D
P
---
P
G
Q
C
R
P
T
V
N
T
L
V
E
F
A
R
R
A
G
V
D
--------------------
P
Q
L
-------
V
N
F
R
N
A
E
---------------------------
D
V
W
N
E
W
R
M
V
S
K
G
--
T
T
Y
D
F
WG
M
T
R
E
R
L
R
K
E
S
--
G
L
I
W
P
C
PS
E
D
H
P
--
G
T
S
L
R
Y
V
------------
R
G
Q
D
P
C
V
P
A
D
H
P
D
R
FF
F
Y
G
K
P
D
G
R
A
V
I
W
M
R
P
-
A
K
---
G
A
A
E
------
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
A
M
E
L
P
A
R
V
S
D
V
--
C
R
----
P
G
L
I
A
V
P
F
F
D
P
----------------
K
K
------------
L
-
V
N
K
L
F
L
D
--
A
T
-
D
P
V
S
R
E
P
E
Y
K
I
-
C
A
A
R
V
R
K
A
-------------------
39
HHSearch
78.97
38%
-61
- C1 -
2NAP
5
NAPA_DESDA
A:
[4-723]
-------------------------------------------
R
P
E
K
W
V
--------
K
G
V
C
R
Y
C
G
T
G
C
G
V
L
V
-
G
V
K
-
D
G
-------------------------------------------
K
A
V
A
I
Q
G
N
P
N
N
--
H
N
A
G
L
L
C
L
K
G
S
L
L
I
P
V
L
N
-----
S
K
-----
E
R
V
T
Q
P
L
V
R
R
H
-----
K
G
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
----
G
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
P
V
L
-
F
--
R
R
I
A
R
---------------
R
K
Q
V
--------------
E
-
P
-
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
M
H
--------
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
E
L
D
N
P
R
F
W
Q
R
Y
V
N
F
M
D
A
E
G
---------------------------
K
P
S
D
F
E
G
Y
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
A
-
E
-----
S
A
-----
A
T
M
S
L
W
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
T
S
F
S
L
T
G
Q
P
N
A
C
G
G
V
R
D
G
G
A
---
L
S
----------
H
L
L
P
A
G
R
A
I
P
N
A
K
H
R
-
A
E
M
E
K
L
W
G
L
P
E
G
R
I
A
P
E
P
G
Y
H
T
V
A
L
F
E
A
L
G
---
R
G
D
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
L
------------------------------
N
K
V
-
H
K
A
M
S
----
H
P
E
S
F
I
V
C
I
E
A
F
P
-
D
A
V
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
E
R
R
--
Y
S
L
T
E
K
A
V
D
P
---
P
G
Q
C
R
P
T
V
N
T
L
V
E
F
A
R
R
A
G
V
D
P
Q
L
V
--
N
F
R
--
N
------------
A
E
D
V
W
N
--------------------------------------
E
W
R
M
V
S
K
G
TT
Y
D
F
W
G
--
M
T
R
E
R
L
R
K
E
S
--
G
L
I
W
P
C
--
P
S
E
D
HP
G
T
S
L
R
Y
V
RGQDPCVPADHP
D
R
F
F
F
Y
G
K
P
D
G
R
A
V
--
I
W
M
R
----------
P
-
A
K
---
G
A
A
E
------
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
--
A
M
E
L
P
A
R
V
S
--
D
V
C
R
P
--
G
L
I
A
V
P
F
F
D
P
----------------
K
K
------------
L
-
V
N
K
L
F
L
D
--
A
T
-
D
P
V
S
R
E
P
E
Y
K
I
-
C
A
A
R
V
R
K
A
-------------------
29
Fugue
68.72
20%
-50
- C1 -
1G8K
6
AIOA_ALCFA
A:
[4-825]
-
N
D
R
I
T
L
P
P
AN
A
Q
R
T
N
M
T
C
H
F
C
I
V
G
C
G
Y
H
V
Y
K
W
P
E
L
E
E
G
G
R
A
P
E
Q
N
A
L
G
LDFRKQLP
P
L
A
V
T
L
T
P
A
M
T
N
V
V
T
E
H
D
G
-
A
R
-------------------------------------------
Y
D
I
M
V
V
P
D
K
A
C
V
-
V
N
S
G
L
S
S
T
R
G
G
K
M
A
S
Y
M
Y
TPTGD
G
K
-----
E
R
L
S
A
P
R
L
Y
-------
A
A
D
E
W
V
D
T
T
W
D
H
A
M
A
L
Y
A
G
L
I
K
K
T
L
D
K
D
G
P
Q
G
V
F
F
S
C
F
DH
G
G
----
A
G
G
G
F
E
N
T
W
G
T
G
K
L
M
F
S
A
I
Q
T
P
M
V
R
I
H
-----
N
R
P
A
Y
N
S
E
C
-
H
A
T
R
E
M
G
I
G
E
L
N
N
A
Y
E
D
A
Q
L
A
D
V
I
W
S
I
G
N
N
P
Y
E
-
S
Q
T
N
Y
-
F
--
L
N
H
W
L
---------------
P
N
L
Q
GAT
T
S
K
K
K
E
R
F
PN
E
N
-
F
P
Q
A
R
I
I
F
V
D
P
R
E
T
P
S
V
A
I
A
--------
R
H
V
AGNDRVLH
L
A
I
E
P
G
T
D
T
A
L
F
N
G
L
F
T
Y
V
V
E
Q
G
W
I
D
K
P
F
I
E
A
H
T
K
------------------------------------
G
F
D
D
A
V
K
T
-
N
R
L
S
L
D
E
C
S
N
I
T
G
V
P
V
D
M
L
K
R
A
A
E
W
S
Y
K
P
-----
K
A
SGQAP
R
T
M
H
A
Y
E
K
G
I
I
W
G
N
D
N
Y
V
I
Q
S
A
L
L
D
L
V
I
A
T
H
N
V
G
R
R
G
T
G
C
V
R
M
G
G
H
Q
E
G
Y
T
R
----
P
P
---
Y
P
----------
G
D
K
K
I
Y
I
D
Q
E
L
I
K
G
K
-
G
R
I
M
T
W
W
G
C
N
N
F
Q
T
S
N
N
---
A
Q
A
L
R
E
A
I
L
Q
---
R
S
A
I
V
K
Q
A
M
Q
K
A
R
G
A
T
T
E
E
M
-------------------------------
V
D
V
I
Y
E
A
T
Q
----
N
G
G
L
F
V
T
S
I
N
L
Y
P
-
T
K
-
L
A
E
A
A
H
L
M
L
P
A
A
H
P
G
E
M
N
L
T
S
M
N
G
E
R
R
--
I
R
L
S
E
K
F
M
D
P
---
P
G
T
A
M
A
D
C
L
I
A
A
R
I
A
N
A
L
R
D
M
Y
Q
-
K
D
G
K
A
E
M
A
A
------
Q
F
E
G
F
D
W
K
T
E
E
D
A
F
N
D
G
F
R
R
A
G
Q
P
G
A
P
A
I
D
S
Q
G
G
S
T
G
H
L
V
T
-------
Y
D
R
L
R
K
S
G
-------------------
N
N
--
G
V
Q
L
P
V
--
V
S
W
D
--
E
S
K
--
G
L
------------
V
G
T
E
M
L
Y
T
E
G
K
------
F
D
T
D
D
G
K
A
H
F
K
P
A
P
-
W
N
GLP
A
T
V
Q
------
Q
Q
K
D
K
Y
R
F
W
L
N
N
G
R
N
-
N
E
V
W
Q
T
A
Y
H
D
Q
Y
N
S
L
M
Q
E
R
Y
P
M
A
Y
I
E
M
N
P
D
D
C
K
Q
L
D
V
T
G
G
D
I
V
E
V
Y
N
D
F
G
--
S
T
F
A
M
V
Y
P
V
----
A
E
I
K
R
G
Q
T
F
M
L
F
G
Y
V
----------------
N
G
------------
I
-
Q
G
D
V
T
T
D
--
W
T
-
D
R
-
D
I
I
P
Y
Y
K
G
-
T
W
G
D
I
R
K
V
G
S
M
S
E
F
K
R
TVSFKSRRFG-
48
HHSearch
66.92
21%
-51
- C1 -
1G8K
5
AIOA_ALCFA
A:
[9-809]
----------------------------------------
L
P
P
A
N
A
Q
R
T
--------
N
M
T
C
H
F
C
I
V
G
C
G
Y
H
V
-
Y
K
W
-
P
E
L
E
E
G
G
RAPEQNALGLDFRKQLPPLA
V
T
L
T
PAM
T
N
V
V
T
E
HDG
A
R
Y
D
I
M
V
V
P
D
K
A
C
V
-
V
N
S
G
L
S
S
T
R
G
G
K
M
A
S
Y
M
Y
-----
T
P
TGDGK
E
R
L
S
A
P
R
L
Y
A
-------
A
D
E
W
V
D
T
T
W
D
H
A
M
A
L
Y
A
G
L
I
K
K
T
L
D
K
D
G
P
Q
G
V
F
F
S
----
C
F
DHGG
A
G
G
G
F
E
N
T
W
G
T
G
K
L
M
F
S
A
I
Q
T
P
M
V
R
I
H
NRPAY
N
S
E
C
H
A
T
R
------
E
M
G
I
G
E
L
N
N
A
Y
E
D
A
Q
L
A
D
V
I
W
S
I
G
N
N
P
Y
E
-
S
Q
T
N
Y
-
F
L
N
H
W
L
P
N
L
Q
GAT
T
S
K
K
K
E
R
F
PN
E
N
F
---------------
P
---
Q
A
R
I
I
F
V
D
P
R
E
T
P
S
V
A
I
A
R
H
V
AGNDR
V
L
H
--------
L
A
I
E
P
G
T
D
T
A
L
F
N
G
L
F
T
Y
V
V
E
Q
G
W
I
D
K
P
F
I
E
A
H
------------------------------------
T
K
G
F
D
D
A
V
K
T
-
N
R
L
S
L
D
E
C
S
N
I
T
G
V
P
V
D
M
L
K
R
A
A
E
W
S
Y
K
P
KASGQ
A
P
-----
R
T
M
H
A
Y
E
K
G
I
I
W
G
N
D
N
Y
V
I
Q
S
A
L
L
D
L
V
I
A
T
H
N
V
G
R
R
G
T
G
C
V
R
M
G
G
H
Q
E
--
G
Y
---------
T
R
----------
P
P
Y
P
G
D
------------------------------
K
K
I
Y
I
D
Q
E
L
I
---
K
G
K
G
R
I
M
T
W
W
G
C
N
N
F
Q
T
S
N
N
A
Q
A
L
R
E
A
I
L
Q
R
S
A
I
V
K
Q
A
M
Q
K
ARGAT
T
E
E
M
V
D
V
I
-
Y
E
A
T
Q
----
N
G
G
L
F
V
T
S
I
N
L
Y
P
-
T
K
-
L
A
E
A
A
H
L
M
L
P
A
A
H
P
G
E
M
N
L
T
S
M
N
G
E
R
R
--
I
R
L
S
E
K
F
M
D
P
---
P
G
T
A
M
A
D
C
L
I
A
A
R
I
A
N
A
L
R
D
M
Y
Q
----
K
D
G
K
A
E
M
A
A
Q
F
E
G
F
D
W
K
T
E
E
D
A
F
N
D
G
F
R
R
A
G
-------------------------
Q
P
G
-
A
P
A
I
D
S
Q
G
G
---
S
T
G
H
L
--
V
T
Y
D
R
L
R
K
S
G
NN
G
V
Q
L
P
V
--
V
S
W
D
ES
K
G
L
V
G
T
E
ML----------
Y
T
E
G
K
F
D
T
D
D
G
K
A
H
--
F
K
P
A
P
W
-----
N
G
L
P
A
T
V
---
Q
---------
Q
Q
K
D
K
Y
R
F
W
L
N
N
G
R
N
-
N
E
V
W
Q
T
A
Y
H
D
Q
Y
N
S
L
M
Q
E
R
Y
P
M
A
Y
I
E
M
N
P
D
D
C
K
Q
L
D
V
T
G
G
D
I
V
E
V
Y
N
D
F
G
--
S
T
F
A
M
V
Y
P
V
--
A
E
I
K
R
--
G
Q
T
F
M
L
F
G
Y
V
----------------
N
G
------------
I
-
Q
G
D
V
T
T
---
D
W
-
T
D
R
D
I
I
P
Y
Y
K
G
-
T
W
G
D
I
R
K
V
G
S
M
----------------
42
HHSearch
66.77
19%
-53
- C1 -
2E7Z
8
AHY_PELAE
A:
[1-727]
-----------------------------------------------
K
K
--------
H
V
V
C
Q
S
C
D
I
N
C
V
V
E
A
-
E
V
K
A
D
G
-------------------------------------------
K
I
Q
T
K
S
I
S
E
P
H
P
T
T
P
P
N
S
I
C
M
K
S
V
N
A
D
T
I
R
T
-----
H
K
-----
D
R
V
L
Y
P
L
K
N
V
G
S
--
K
R
G
E
Q
R
W
E
R
I
S
W
D
Q
A
L
D
E
I
A
E
K
L
K
K
I
I
A
K
Y
G
P
E
S
L
G
V
S
----
Q
T
----
E
I
N
Q
Q
S
E
Y
G
T
L
R
R
F
M
N
-
L
L
G
S
P
N
W
T
S
A
-----
M
Y
M
C
I
G
N
T
A
G
V
H
R
V
T
H
G
S
----
Y
S
F
A
S
F
A
D
S
N
C
L
L
F
I
G
K
N
L
S
N
-
H
N
W
V
S
Q
F
--
N
D
L
K
A
---------------
A
L
K
---------------
R
---
G
C
K
L
I
V
L
D
P
R
R
T
K
V
A
E
M
A
--------
D
I
W
--------
L
P
L
R
Y
G
T
D
A
A
L
F
L
G
M
I
N
V
I
I
N
E
Q
L
Y
D
K
E
F
V
E
N
W
------------------------------------
C
V
G
F
E
E
L
K
E
R
V
Q
E
Y
P
L
D
K
V
A
E
I
T
G
C
D
A
G
E
I
R
K
A
A
V
M
F
A
-
T
-----
E
S
-----
P
A
S
I
P
W
A
V
S
T
D
M
Q
K
N
S
C
S
A
I
R
A
Q
C
I
L
R
A
I
V
G
S
F
V
N
-
G
A
E
I
L
G
A
P
H
S
D
L
V
-
P
I
-
S
K
I
Q
M
HEA
L
P
E
E
K
K
K
L
QLGT
E
T
Y
P
F
L
T
-
Y
T
G
M
S
A
L
E
E
P
S
E
R
V
Y
G
V
K
Y
F
H
N
M
G
A
F
M
A
N
P
T
A
L
F
T
A
M
A
TEK
P
Y
P
V
K
A
F
F
A
L
A
S
N
A
L
M
G
Y
A
N
Q
------------------------------
Q
N
A
-
L
K
G
L
M
----
N
Q
-
D
L
V
V
C
Y
D
Q
F
M
-
T
P
-
T
A
Q
L
A
D
Y
V
L
P
G
D
H
W
L
E
R
P
V
V
Q
P
N
W
E
G
I
P
F
G
N
T
S
Q
Q
V
V
E
P
---
A
G
E
A
K
D
E
Y
Y
F
I
R
E
L
A
V
R
M
G
L
E
E
H
-
F
--
P
W
K
D
R
--------------
L
E
L
I
N
Y
-------------------------------------
R
I
S
---------
P
T
G
--
M
E
W
E
E
Y
Q
K
Q
Y
--
T
Y
M
S
K
L
--
P
D
------
Y
--
F
G
------------
P
E
G
V
G
V
A
T
P
S
G
K
V
E
--
L
Y
S
S
V
F
E
K
L
G
Y
D
P
L
P
Y
Y
H
---
E
P
L
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TEISD
P
E
L
A
K
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Y
P
L
I
L
F
A
G
L
R
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D
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N
F
Q
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C
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--
H
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P
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P
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A
L
L
H
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K
T
A
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L
G
L
P
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G
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W
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W
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--
R
L
K
L
L
L
K
H
D
--
G
A
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P
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--
G
T
I
R
I
P
H
G
R
W
CPEQEGGPETGFSGAM
L
H
------------
N
D
A
M
V
L
S
D
D
DW
N
L
-
D
P
E
Q
G
L
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N
L
R
G
G
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L
A
K
A
Y
K
C
-------------------
31
Fugue
66.73
20%
-51
- C1 -
2VPZ
4
?
A:
[30-763]
--------
A
----------
P
W
Y
A
Q
E
V
K
S
V
Y
Q
I
----------------------------
C
E
G
C
F
W
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C
G
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V
A
-
H
A
V
-
G
N
-------------------------------------------
R
V
Y
K
V
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N
P
-
K
S
R
G
R
L
C
P
R
G
Q
G
A
P
Q
T
T
Y
-----
D
P
-----
D
R
L
K
R
P
L
I
R
-
V
E
G
S
Q
R
G
E
G
K
Y
R
V
A
T
W
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A
L
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H
I
A
K
K
M
L
E
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R
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K
Y
G
P
E
A
I
A
F
F
----
G
H
----
G
T
G
---
D
Y
W
F
V
D
F
L
P
A
A
W
G
S
P
N
A
A
K
P
S
-----
V
S
L
C
T
A
P
R
E
V
A
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Q
W
V
F
G
R
P
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G
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H
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A
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V
L
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H
H
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G
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D
T
H
N
T
Q
-
L
--
Q
D
F
-----------------
A
L
A
---------------
L
-
K
N
G
A
K
V
V
V
V
D
P
R
F
S
T
A
A
A
K
A
--------
H
R
W
--------
L
P
I
K
P
G
T
D
T
A
L
L
L
A
W
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L
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Y
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D
L
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D
K
E
Y
V
A
K
Y
T
V
------------------------------------
G
F
E
E
L
K
A
H
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K
D
F
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P
E
W
A
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K
H
T
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P
A
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R
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A
R
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M
A
A
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-----
K
P
-----
R
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L
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P
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R
H
N
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W
Y
G
D
D
T
Y
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G
F
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P
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L
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K
Y
P
L
P
P
L
P
L
E
---
P
A
----------
A
G
G
C
S
G
P
S
G
G
D
H
E
P
E
-
G
F
K
----
P
R
A
D
K
G
K
F
F
A
R
S
T
A
I
Q
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L
I
E
P
M
I
TGE
P
Y
P
I
K
G
L
F
A
Y
G
I
N
L
F
H
S
I
P
N
-------------------------------
V
P
R
T
K
E
A
L
K
----
N
L
D
-
L
Y
V
A
I
D
V
L
P
-
Q
E
-
H
V
M
W
A
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L
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D
D
F
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L
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--
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F
I
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L
R
T
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A
HEP
L
F
D
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K
P
G
W
W
I
A
R
E
L
G
L
R
L
G
L
E
Q
Y
-
F
--
P
W
K
T
I
E
------
E
Y
L
E
T
R
L
Q
S
L
--------------------
G
L
D
L
E
T
M
K
G
M
G
T
L
V
Q
R
G
---------------------------
K
P
W
--
L
E
D
W
E
K
--
E
G
R
L
------------------------
P
F
G
T
A
S
G
K
I
E
L
--
Y
C
Q
R
F
K
E
A
G
H
Q
P
L
P
V
-
F
T
---
P
P
E
E
------
P
P
E
G
F
Y
R
--
L
L
Y
G
R
S
---
P
V
H
T
F
A
R
T
Q
N
N
W
V
L
M
E
M
D
P
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N
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W
I
H
K
E
E
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L
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L
K
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Y
V
M
L
V
N
Q
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--
V
K
E
G
P
V
R
V
K
--
P
T
A
R
I
R
K
D
C
V
Y
I
V
H
G
F
G
----------------
H
K
APLMRLAHGRGA
S
-
D
N
Y
L
Q
T
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--
Y
K
L
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P
I
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G
A
G
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-
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