@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA1197: (2016-01-27 )
MDSHSPIATVAQALRRAERILVITGAGLSADSGMPTYRGLGGLYNGRTEEGLPIEAALSGPMLRRDPALCWKYLAELGKACLAARPNAGHEAIAELQKHKPECWVLTQNIDGFHRQAGSPAERLIEIHGELAPLYCQSCGAESGGLEEHLHGQLPPRCAACGGVLRPPVVLFEEMLPEEAIDTLYRELRKGFDAVLVVGTTASFPYIVEPVLRTRQAGGFTAEVNPGVTDLSERVDVKMTGRALDIMPQVVSHIYR
Atome Classification :
(43 SA)
----------------------------------------------------------------------------.........10........20........30........40........50-...-......60........70........80........90....----...----.100.......110.......120.......130.......140.-------------------.---......-------------------.150...--...--.160..-----.-......170.......180.......--190.......200-----.-.-..-....210---........220...---....230...-----....240.......250....-----------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------MDSHS
P
I
A
T
V
A
Q
A
L
R
RA
E
R
I
L
V
I
TGAGLSADSGMP
T
Y
RGLGGLYNGRTEE--GL
P
-
I
EAALSGPMLRR
D
P
A
L
C
W
K
Y
L
A
E
L
G
K
A
C
L
AARPNA
G
H
E
A
I
A
E
----
L
Q
K----HKP
E
C
W
V
L
TQNI
D
G
F
H
RQAG
S
P
A
E
R
L
I
E
I
HGE
L
A
P
L
Y
C
Q
SCG--A-------------------E---SGG
L
E
E
-------------------
H
LHGQLP--
P
R
C
--
A
A--CG-----G-VLR
P
P
V
V
L
F
E
E
ML
P
E
E
A
I
D
T
L
Y
R
E
L
R
--KGF
D
A
V
L
V
V
GTT------A-S-
F
P
-
Y
I
V
E
P
V
----
L
R
T
RQAG
G
F
T
A
EVN---PGVT
D
L
S
ERV-----
D
V
K
MTG
R
A
L
D
I
M
P
Q
V
V
S
H
IYR-----------------------------------
10
PsiBlast_PDB
89.06
36%
-102
- C4 -
4TWJ
9
NPD2_ARCFU
A:
[5-248]
----------------------------------------------------------------------------------
I
R
K
A
A
E
I
L
A
K
S
K
H
A
V
V
F
T
G
A
G
I
S
A
E
-----------------
P
E
--
E
V
----
A
S
I
S
G
--
F
K
R
N
P
R
A
F
W
E
F
S
M
E
M
-
K
D
K
L
F
A
E
P
N
P
A
H
Y
A
I
A
E
----
L
E
R
----
M
G
I
V
K
A
V
I
T
Q
N
I
D
M
L
H
Q
R
A
G
S
--
R
R
V
L
E
L
H
G
S
M
D
K
L
D
C
L
D
C
H
--
E
-------------------
T
Y
D
W
S
E
F
V
E
D
-------------------
F
N
K
G
E
I
---
P
R
C
--
R
K
--
C
G
-----
S
Y
Y
V
K
P
R
V
V
L
F
G
E
P
L
P
Q
R
---
T
L
F
E
A
I
E
E
A
K
H
C
D
A
F
M
V
V
G
S
S
LVVYPA
A
-
E
-
L
P
-
Y
I
----------
A
K
K
A
G
A
K
M
I
I
V
N
---
A
E
P
T
M
A
D
P
I
F
-----
D
V
K
I
I
G
K
A
G
E
V
L
P
K
I
V
E
E
V
K
R
-----------------------------------
23
PsiBlast_CBE
88.38
36%
-94
- C4 -
1YC2
1
NPD2_ARCFU
E:
[5-248]
----------------------------------------------------------------------------------
I
R
K
A
A
E
I
L
A
K
S
K
H
A
V
V
F
T
G
A
G
I
S
A
E
S
G
I
P
T
F
R
G
E
D
G
L
W
R
K
Y
D
P
E
--
E
V
----
A
S
I
S
G
--
F
K
R
N
P
R
A
F
W
E
F
S
M
E
M
-
K
D
K
L
F
A
E
P
N
P
A
H
Y
A
I
A
E
----
L
E
R
----
M
G
I
V
K
A
V
I
T
Q
N
I
D
M
L
H
Q
R
A
G
S
--
R
R
V
L
E
L
H
G
S
M
D
K
L
D
C
L
D
C
H
--
E
-------------------
T
YDW
S
E
F
V
E
D
-------------------
F
N
K
G
E
I
---
P
R
C
--
R
K
--
C
G
-----
S
Y
Y
V
K
P
R
V
V
L
F
G
E
P
L
P
Q
R
---
T
L
F
E
A
I
E
EA
K
H
C
D
A
F
M
V
V
G
S
S
LVVYPA
A
-
E
-
L
P
-
Y
I
----------
A
K
K
A
G
A
K
M
I
I
V
N
---
A
E
P
T
M
A
D
P
I
F
-----
D
V
K
I
I
G
K
A
G
E
V
L
P
K
I
V
E
E
V
K
R
-----------------------------------
107
HHSearch
88.37
34%
-96
- C4 -
3RIY
3
SIR5_HUMAN
A:
[7-273]
------------------------------------------------------------------------------
P
S
S
S
M
A
D
F
R
K
F
F
A
K
A
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
G
G
Y
W
R
K
-------
W
Q
-
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
E
V
M
G
S
K
E
P
N
A
G
H
R
A
I
A
E
----
C
E
T
R
L
G
K
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
T
K
--
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
--
V
-------------------
V
---
A
E
N
Y
K
S
PICPALSGKGAPEPGTQDA
S
I
P
V
E
K
L
--
P
R
C
--
E
E
AG
C
G
-----
G
-
L
L
R
P
H
V
V
W
F
G
E
N
L
D
P
A
I
L
E
E
V
D
R
E
L
A
--
H
-
C
D
L
C
L
V
V
G
T
S
------
S
-
V
V
Y
P
-
A
A
M
F
A
P
----
Q
-
V
A
A
R
G
V
P
V
A
E
F
N
---
T
E
T
T
P
A
T
N
R
F
-----
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
A
---------------------------------------
26
PsiBlast_CBE
87.83
36%
-95
- C4 -
1YC2
8
NPD2_ARCFU
B:
[5-248]
----------------------------------------------------------------------------------
I
R
K
A
A
E
I
L
A
K
S
K
H
A
V
V
F
T
G
A
G
I
S
A
E
S
G
I
P
T
F
R
G
E
D
G
L
W
R
K
Y
D
P
E
--
E
V
----
A
S
I
S
G
--
F
K
R
N
P
R
A
F
W
E
F
S
M
E
M
-
K
D
K
L
F
A
E
P
N
P
A
H
Y
A
I
A
E
----
L
E
R
----
M
G
I
V
K
A
V
I
T
Q
N
I
D
M
L
H
Q
R
A
G
S
--
R
R
V
L
E
L
H
G
S
M
D
K
L
D
C
L
D
C
H
--
E
-------------------
T
YDW
S
E
F
V
E
D
-------------------
F
N
K
G
E
I
---
P
R
C
--
R
K
--
C
G
-----
S
Y
Y
V
K
P
R
V
V
L
F
G
E
P
L
P
Q
R
---
T
L
F
E
A
I
E
EA
K
H
C
D
A
F
M
V
V
G
S
S
LVVYPA
A
-
E
-
L
P
-
Y
I
----------
A
K
K
A
G
A
K
M
I
I
V
N
---
A
E
P
T
M
A
D
P
I
F
-----
D
V
K
I
I
G
K
A
G
E
V
L
P
K
I
V
E
E
V
K
R
-----------------------------------
27
PsiBlast_CBE
87.44
36%
-87
- C4 -
1S7G
1
NPD2_ARCFU
E:
[5-248]
----------------------------------------------------------------------------------
I
R
K
A
A
E
I
L
A
K
S
K
H
A
V
V
F
T
G
A
G
I
S
A
E
S
G
I
P
T
F
R
G
E
D
G
L
W
R
K
Y
D
P
E
--
E
V
----
A
S
I
S
G
--
F
K
R
N
P
R
A
F
W
E
F
S
M
E
M
-
K
D
--
F
A
E
P
N
P
A
H
Y
A
I
A
E
----
L
E
R
----
M
G
I
V
K
A
V
I
T
Q
N
I
D
M
L
H
Q
R
A
G
S
--
R
R
V
L
E
L
H
G
S
M
D
K
L
D
C
L
D
C
H
--
E
-------------------
T
YDW
S
E
F
V
E
D
-------------------
F
N
K
G
E
I
---
P
R
C
--
R
K
--
C
G
-----
S
Y
Y
V
K
P
R
V
V
L
F
G
E
P
L
P
Q
R
---
T
L
F
E
A
I
E
EA
K
H
C
D
A
F
M
V
V
G
S
S
LVVYPA
A
-
E
-
L
P
-
Y
I
----------
A
K
K
A
G
A
K
M
I
I
V
N
---
A
E
P
T
M
A
D
P
I
F
-----
D
V
K
I
I
G
K
A
G
E
V
L
P
K
I
V
E
E
V
K
R
-----------------------------------
29
PsiBlast_CBE
87.41
36%
-94
- C4 -
1S7G
6
NPD2_ARCFU
B:
[5-248]
----------------------------------------------------------------------------------
I
R
K
A
A
E
I
L
A
K
S
K
H
A
V
V
F
T
G
A
G
I
S
A
E
S
G
I
P
T
F
R
G
E
D
G
L
W
R
K
Y
D
P
E
--
E
V
----
A
S
I
S
G
--
F
K
R
N
P
R
A
F
W
E
F
S
M
E
M
-
K
D
K
L
F
A
E
P
N
P
A
H
Y
A
I
A
E
----
L
E
R
----
M
G
I
V
K
A
V
I
T
Q
N
I
D
M
L
H
Q
R
A
G
S
--
R
R
V
L
E
L
H
G
S
M
D
K
L
D
C
L
D
C
H
--
E
-------------------
T
Y
DW
S
E
F
V
E
D
-------------------
F
N
K
G
E
I
---
P
R
C
--
R
K
--
C
G
-----
S
Y
Y
V
K
P
R
V
V
L
F
G
E
P
L
P
Q
R
---
T
L
F
E
A
I
E
EA
K
H
C
D
A
F
M
V
V
G
S
S
L
V
V
Y
P
A
A
-
E
-
L
P
-
Y
I
----------
A
K
K
A
G
A
K
M
I
I
V
N
---
A
E
P
T
M
A
D
P
I
F
-----
D
V
K
I
I
G
K
A
G
E
V
L
P
K
I
V
E
E
V
K
R
-----------------------------------
25
PsiBlast_CBE
87.27
36%
-91
- C4 -
1YC2
7
NPD2_ARCFU
C:
[5-248]
----------------------------------------------------------------------------------
I
R
K
A
A
E
I
L
A
K
S
K
H
A
V
V
F
T
G
A
G
I
S
A
E
S
G
I
P
T
F
R
G
E
D
G
L
W
R
K
Y
D
P
E
--
E
V
----
A
S
I
S
G
--
F
K
R
N
P
R
A
F
W
E
F
S
M
E
M
-
K
D
K
L
F
A
E
P
N
P
A
H
Y
A
I
A
E
----
L
E
R
----
M
G
I
V
K
A
V
I
T
Q
N
I
D
M
L
H
Q
R
A
G
S
--
R
R
V
L
E
L
H
G
S
M
D
K
L
D
C
L
D
C
H
--
E
-------------------
T
YDW
S
E
F
V
E
D
-------------------
F
N
K
G
E
I
---
P
R
C
--
R
K
--
C
G
-----
S
Y
Y
V
K
P
R
V
V
L
F
G
E
P
L
P
Q
R
---
T
L
F
E
A
I
E
EA
K
H
C
D
A
F
M
V
V
G
S
S
LVVYPA
A
-
E
-
L
P
-
Y
I
----------
A
K
K
A
G
A
K
M
I
I
V
N
---
A
E
P
T
M
A
D
P
I
F
-----
D
V
K
I
I
G
K
A
G
E
V
L
P
K
I
V
E
E
V
K
R
-----------------------------------
28
PsiBlast_CBE
86.47
36%
-90
- C4 -
1S7G
7
NPD2_ARCFU
C:
[5-248]
----------------------------------------------------------------------------------
I
R
K
A
A
E
I
L
A
K
S
K
H
A
V
V
F
T
G
A
G
I
S
A
E
S
G
I
P
T
F
R
G
E
D
G
L
W
R
K
Y
D
P
E
--
E
V
----
A
S
I
S
G
--
F
K
R
N
P
R
A
F
W
E
F
S
M
E
M
-
K
D
K
L
F
A
E
P
N
P
A
H
Y
A
I
A
E
----
L
E
R
----
M
G
I
V
K
A
V
I
T
Q
N
I
D
M
L
H
Q
R
A
G
S
--
R
R
V
L
E
L
H
G
S
M
D
K
L
D
C
L
D
C
H
--
E
-------------------
T
YDW
S
E
F
V
E
D
-------------------
F
N
K
G
E
I
---
P
R
C
--
R
K
--
C
G
-----
S
Y
Y
V
K
P
R
V
V
L
F
G
E
P
L
P
Q
R
---
T
L
F
E
A
I
E
E
A
K
H
C
D
A
F
M
V
V
G
S
S
LVVYPA
A
-
E
-
L
P
-
Y
I
----------
A
K
K
A
G
A
K
M
I
I
V
N
---
A
E
P
T
M
A
D
P
I
F
-----
D
V
K
I
I
G
K
A
G
E
V
L
P
K
I
V
E
E
V
K
R
-----------------------------------
14
PsiBlast_PDB
86.46
32%
-96
- C4 -
4F56
3
SIR5_HUMAN
A:
[9-273]
--------------------------------------------------------------------------------
S
S
M
A
D
F
R
K
F
F
A
K
A
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
G
G
Y
W
R
K
W
Q
A
Q
--
D
L
A
-
T
P
L
A
F
A
-----
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
E
V
M
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
E
T
R
L
G
K
----
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
T
--
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
--
V
V
A
E
N
YKSPICPALSGKGAP
E
---
P
G
T
Q
D
A
-------------------
S
I
P
V
E
K
L
--
P
R
C
EE
A
G
--
C
G
-----
G
-
L
L
R
P
H
V
V
W
F
G
E
N
L
D
P
A
I
L
E
E
V
D
R
E
L
A
--
H
-
C
D
L
C
L
V
V
G
T
S
------
S
V
V
-
Y
P
A
A
M
F
A
P
Q
----
V
A
A
R
--
G
V
P
V
A
E
F
N
---
T
E
T
T
P
A
T
N
R
F
-----
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
A
---------------------------------------
13
PsiBlast_PDB
86.16
32%
-99
- C4 -
4F4U
2
SIR5_HUMAN
A:
[9-273]
--------------------------------------------------------------------------------
S
S
M
A
D
F
R
K
F
F
A
K
A
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
----
G
Y
W
R
K
W
Q
A
Q
--
D
L
A
-
T
P
L
A
F
A
-----
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
E
V
M
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
E
T
R
L
G
K
----
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
T
--
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
--
V
V
A
E
N
YKSPICPALSGKGAP
E
---
P
G
T
Q
D
A
-------------------
S
I
P
V
E
K
L
--
P
R
C
EE
A
G
--
C
G
-----
G
-
L
L
R
P
H
V
V
W
F
G
E
N
L
D
P
A
I
L
E
E
V
D
R
E
L
A
--
H
-
C
D
L
C
L
V
V
G
T
S
------
S
V
V
-
Y
P
A
A
M
F
A
P
Q
----
V
A
A
R
--
G
V
P
V
A
E
F
N
---
T
E
T
T
P
A
T
N
R
F
-----
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
A
---------------------------------------
31
PsiBlast_CBE
85.83
32%
-95
- C4 -
3RIY
3
SIR5_HUMAN
B:
[9-273]
--------------------------------------------------------------------------------
S
S
M
A
D
F
R
K
F
F
A
K
A
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
G
G
Y
W
R
K
W
Q
A
Q
--
D
L
A
-
T
P
L
A
F
A
-----
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
E
V
M
G
S
K
E
P
N
A
G
H
R
A
I
A
E
CETR
L
G
K
----
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
T
--
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
--
V
VAENYKSPICPALSGKGAP
E
---
P
G
T
Q
D
A
-------------------
S
I
P
V
E
K
L
--
P
R
C
EE
A
G
--
C
G
-----
G
-
L
L
R
P
H
V
V
W
F
G
E
N
L
D
P
A
I
L
E
E
V
D
R
E
L
A
--
H
-
C
D
L
C
L
V
V
G
T
S
------
S
V
V
-
Y
P
A
A
M
F
A
P
Q
----
V
A
A
R
--
G
V
P
V
A
E
F
N
---
T
E
T
T
P
A
T
N
R
F
-----
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
A
---------------------------------------
99
Fugue
85.76
26%
-99
- C4 -
5BTR
6
?
A:
[4-390]
DNLLFGD
E
I
I
T
N
GSDWTP
R
P
R
I
G
P
Y
T
F
V
Q
Q
H
L
M
I
GTD
P
R
T
I
L
K
D
L
LPETIPPPELD
D
M
T
L
W
Q
I
V
I
N
I
L
S
E
P
P
K
R
K
K
R
K
D
I
N
T
I
E
D
A
V
K
L
L
Q
E
S
K
K
I
I
V
L
T
G
A
G
V
S
V
S
S
G
I
P
D
F
R
S
R
D
G
I
Y
A
R
L
A
V
D
F
P
D
L
P
D
P
Q
A
M
F
D
I
E
Y
F
R
K
D
P
R
P
F
F
K
F
A
K
E
I
Y
P
G
--
Q
F
Q
P
S
L
C
H
K
F
I
A
L
----
S
D
K
----
E
G
K
L
L
R
N
Y
T
Q
N
I
D
T
L
E
Q
V
A
G
--
I
Q
R
I
I
Q
C
H
G
S
F
A
T
A
S
C
L
I
C
K
Y
K
V
-------------------
D
---
C
E
A
V
R
G
-------------------
D
I
F
N
Q
V
V
--
P
R
C
--
P
R
--
C
P
ADEPL
A
-
I
M
K
P
E
I
V
F
F
G
E
N
L
P
-
E
Q
F
H
R
A
M
K
Y
D
K
--
D
E
V
D
L
L
I
V
I
G
S
S
-----------------------
L
K
V
R
P
V
A
L
I
P
S
S
I
P
HEV
P
Q
I
L
I
N
R
E
P
L
PHLHF
D
V
E
L
L
G
D
C
D
V
I
I
N
E
L
C
H
R
L
G
G
EYAKLSSNP
V
K
L
S
E
ITE
Q
Y
L
F
L
P
P
N
R
Y
I
F
H
GAEVY
9
PsiBlast_PDB
85.75
36%
-93
- C4 -
1YC2
7
NPD2_ARCFU
A:
[5-248]
----------------------------------------------------------------------------------
I
R
K
A
A
E
I
L
A
K
S
K
H
A
V
V
F
T
G
A
G
I
S
A
E
S
G
I
P
T
F
R
G
E
D
G
L
W
R
K
Y
D
P
E
--
E
V
----
A
S
I
S
G
--
F
K
R
N
P
R
A
F
W
E
F
S
M
E
M
-
K
D
K
L
F
A
E
P
N
P
A
H
Y
A
I
A
E
----
L
E
R
----
M
G
I
V
K
A
V
I
T
Q
N
I
D
M
L
H
Q
R
A
G
S
--
R
R
V
L
E
L
H
G
S
M
D
K
L
D
C
L
D
C
H
--
E
-------------------
T
Y
D
W
S
E
F
V
E
D
-------------------
F
N
K
G
E
I
---
P
R
C
--
R
K
--
C
G
-----
S
Y
Y
V
K
P
R
V
V
L
F
G
E
P
L
P
Q
R
---
T
L
F
E
A
I
E
E
A
K
H
C
D
A
F
M
V
V
G
S
S
LVVYPA
A
-
E
-
L
P
-
Y
I
----------
A
K
K
A
G
A
K
M
I
I
V
N
---
A
E
P
T
M
A
D
P
I
F
-----
D
V
K
I
I
G
K
A
G
E
V
L
P
K
I
V
E
E
V
K
R
-----------------------------------
95
Fugue
85.71
33%
-94
- C4 -
1ICI
2
NPD1_ARCFU
A:
[1-256]
----------------------------------------------------------------------GSHH
H
H
H
H
G
S
H
M
D
E
K
L
L
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
D
G
L
W
N
R
Y
-------
R
-
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
E
K
V
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
----
L
E
R
----
L
G
V
L
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
S
R
--
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
N
--
N
-------------------
S
---
F
E
-
V
E
S
-------------------
A
P
K
I
P
P
L
--
P
K
C
--
D
K
--
C
G
-----
S
-
L
L
R
P
G
V
V
W
F
G
E
M
L
P
P
D
V
L
D
R
A
M
R
E
V
E
--
R
A
-
D
V
I
I
V
A
G
T
S
------
A
-
V
-
V
Q
-
P
A
A
S
L
P
----
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
---
P
D
E
T
P
L
T
P
I
A
-----
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
K
A
L
S--------------------------------
15
PsiBlast_PDB
85.49
32%
-102
- C4 -
2NYR
2
SIR5_HUMAN
A:
[7-271]
--------------------------------------------------------------------------------
S
S
M
A
D
F
R
K
F
F
A
K
A
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
G
G
Y
W
R
K
W
Q
A
Q
--
D
L
A
-
T
P
L
A
F
A
-----
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
E
V
M
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
E
T
R
L
G
K
----
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
T
--
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
--
V
V
A
E
N
YKSPICPALSGKGAP
E
---
P
G
T
Q
D
A
-------------------
S
I
P
V
E
K
L
--
P
R
C
EE
A
G
--
C
G
-----
G
-
L
L
R
P
H
V
V
W
F
G
E
N
L
D
P
A
I
L
E
E
V
D
R
E
L
A
--
H
-
C
D
L
C
L
V
V
G
T
S
------
S
V
V
-
Y
P
A
A
M
F
A
P
Q
----
V
A
A
R
--
G
V
P
V
A
E
F
N
---
T
E
-------------
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
A
---------------------------------------
12
PsiBlast_PDB
85.31
32%
-96
- C4 -
3RIY
3
SIR5_HUMAN
A:
[9-273]
--------------------------------------------------------------------------------
S
S
M
A
D
F
R
K
F
F
A
K
A
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
G
G
Y
W
R
K
W
Q
A
Q
--
D
L
A
-
T
P
L
A
F
A
-----
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
E
V
M
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
E
T
R
L
G
K
----
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
T
--
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
--
V
V
A
E
N
YKSPICPALSGKGAP
E
---
P
G
T
Q
D
A
-------------------
S
I
P
V
E
K
L
--
P
R
C
EE
A
G
--
C
G
-----
G
-
L
L
R
P
H
V
V
W
F
G
E
N
L
D
P
A
I
L
E
E
V
D
R
E
L
A
--
H
-
C
D
L
C
L
V
V
G
T
S
------
S
V
V
-
Y
P
A
A
M
F
A
P
Q
----
V
A
A
R
--
G
V
P
V
A
E
F
N
---
T
E
T
T
P
A
T
N
R
F
-----
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
A
---------------------------------------
8
PsiBlast_PDB
85.24
36%
-94
- C4 -
1S7G
7
NPD2_ARCFU
A:
[5-248]
----------------------------------------------------------------------------------
I
R
K
A
A
E
I
L
A
K
S
K
H
A
V
V
F
T
G
A
G
I
S
A
E
S
G
I
P
T
F
R
G
E
D
G
L
W
R
K
Y
D
P
E
--
E
V
----
A
S
I
S
G
--
F
K
R
N
P
R
A
F
W
E
F
S
M
E
M
-
K
D
K
L
F
A
E
P
N
P
A
H
Y
A
I
A
E
----
L
E
R
----
M
G
I
V
K
A
V
I
T
Q
N
I
D
M
L
H
Q
R
A
G
S
--
R
R
V
L
E
L
H
G
S
M
D
K
L
D
C
L
D
C
H
--
E
-------------------
T
Y
D
W
S
E
F
V
E
D
-------------------
F
N
K
G
E
I
---
P
R
C
--
R
K
--
C
G
-----
S
Y
Y
V
K
P
R
V
V
L
F
G
E
P
L
P
Q
R
---
T
L
F
E
A
I
E
E
A
K
H
C
D
A
F
M
V
V
G
S
S
LVVYPA
A
-
E
-
L
P
-
Y
I
----------
A
K
K
A
G
A
K
M
I
I
V
N
---
A
E
P
T
M
A
D
P
I
F
-----
D
V
K
I
I
G
K
A
G
E
V
L
P
K
I
V
E
E
V
K
R
-----------------------------------
18
PsiBlast_PDB
85.23
31%
-99
- C4 -
2B4Y
3
SIR5_HUMAN
A:
[7-271]
--------------------------------------------------------------------------------
S
S
M
A
D
F
R
K
F
F
A
K
A
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
-------
G
Y
W
R
K
W
Q
A
Q
--
D
L
A
-
T
P
L
A
F
A
-----
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
E
V
M
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
E
T
R
L
G
K
----
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
T
--
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
--
V
V
A
E
N
YKSPICPALSGKGAP
E
---
P
G
T
Q
D
A
-------------------
S
I
P
V
E
K
L
--
P
R
C
EE
A
G
--
C
G
-----
G
-
L
L
R
P
H
V
V
W
F
G
E
N
L
D
P
A
I
L
E
E
V
D
R
E
L
A
--
H
-
C
D
L
C
L
V
V
G
T
S
------
S
-
V
-
V
Y
-
P
A
A
M
F
A
----
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
---
T
E
T
T
P
A
T
N
R
F
-----
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
A
---------------------------------------
24
PsiBlast_CBE
85.22
36%
-93
- C4 -
1YC2
17
NPD2_ARCFU
D:
[5-248]
----------------------------------------------------------------------------------
I
R
K
A
A
E
I
L
A
K
S
K
H
A
V
V
F
T
G
A
G
I
S
A
E
S
G
I
P
T
F
R
G
E
D
G
L
W
R
K
Y
D
P
E
--
E
V
----
A
S
I
S
G
--
F
K
R
N
P
R
A
F
W
E
F
S
M
E
M
-
K
D
K
L
F
A
E
P
N
P
A
H
Y
A
I
A
E
----
L
E
R
----
M
G
I
V
K
A
V
I
T
Q
N
I
D
M
L
H
Q
R
A
G
S
--
R
R
V
L
E
L
H
G
S
M
D
K
L
D
C
L
D
C
H
--
E
-------------------
T
YDW
S
E
F
V
E
D
-------------------
F
N
K
G
E
I
---
P
R
C
--
R
K
--
C
G
-----
S
Y
Y
V
K
P
R
V
V
L
F
G
E
P
L
P
Q
R
---
T
L
F
E
A
I
E
EA
K
H
C
D
A
F
M
V
V
G
S
S
LVVYPA
A
-
E
-
L
P
-
Y
I
----------
A
K
K
A
G
A
K
M
I
I
V
N
---
A
E
P
T
M
A
D
P
I
F
-----
D
V
K
I
I
G
K
A
G
E
V
L
P
K
I
V
E
E
V
K
R
-----------------------------------
34
PsiBlast_CBE
85.18
32%
-98
- C4 -
4G1C
3
SIR5_HUMAN
B:
[3-267]
--------------------------------------------------------------------------------
S
S
M
A
D
F
R
K
F
F
A
K
A
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
G
G
Y
W
R
K
W
Q
A
Q
--
D
L
A
-
T
P
L
A
F
A
-----
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
E
V
M
G
S
K
E
P
N
A
G
H
R
A
I
A
E
CETR
L
G
K
----
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
T
--
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
--
V
VAENYKSPICPALSGKGAP
E
---
P
G
T
Q
D
A
-------------------
S
I
P
V
E
K
L
--
P
R
C
EE
A
G
--
C
G
-----
G
-
L
L
R
P
H
V
V
W
F
G
E
N
L
D
P
A
I
L
E
E
V
D
R
E
L
A
--
H
-
C
D
L
C
L
V
V
G
T
S
------
S
V
V
-
Y
P
A
A
M
F
A
P
Q
----
V
A
A
R
--
G
V
P
V
A
E
F
N
---
T
E
T
T
P
A
T
N
R
F
-----
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
A
---------------------------------------
16
PsiBlast_PDB
84.95
32%
-95
- C4 -
4G1C
4
SIR5_HUMAN
A:
[3-267]
--------------------------------------------------------------------------------
S
S
M
A
D
F
R
K
F
F
A
K
A
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
G
G
Y
W
R
K
W
Q
A
Q
--
D
L
A
-
T
P
L
A
F
A
-----
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
E
V
M
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
E
T
R
L
G
K
----
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
T
--
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
--
V
V
A
E
N
YKSPICPALSGKGAP
E
---
P
G
T
Q
D
A
-------------------
S
I
P
V
E
K
L
--
P
R
C
EE
A
G
--
C
G
-----
G
-
L
L
R
P
H
V
V
W
F
G
E
N
L
D
P
A
I
L
E
E
V
D
R
E
L
A
--
H
-
C
D
L
C
L
V
V
G
T
S
------
S
V
V
-
Y
P
A
A
M
F
A
P
Q
----
V
A
A
R
--
G
V
P
V
A
E
F
N
---
T
E
T
T
P
A
T
N
R
F
-----
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
A
---------------------------------------
6
PsiBlast_PDB
82.55
34%
-88
- C4 -
1M2J
2
NPD1_ARCFU
A:
[7-242]
---------------------------------------------------------------------------------------
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
D
G
L
W
N
R
Y
R
P
E
--
E
L
A
-
N
P
Q
A
F
A
-----
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
E
K
V
F
N
A
Q
P
N
K
A
N
Q
A
F
A
E
----
L
E
R
----
L
G
V
L
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
S
--
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
---------------------------
N
N
S
F
E
V
-------------------
E
S
A
P
K
I
P
PL
P
K
C
--
D
K
--
C
G
-----
S
-
L
L
R
P
G
V
V
W
F
G
E
M
L
P
P
D
V
L
D
R
A
M
R
E
V
E
--
R
A
-
D
V
I
I
V
A
G
T
S
------
A
-------
V
V
Q
P
A
AS
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
---
P
D
E
T
P
L
T
P
I
A
-----
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
K
-----------------------------------
38
PsiBlast_CBE
82.33
32%
-86
- C4 -
4UUA
5
SIR5_DANRE
B:
[11-271]
--------------------------------------------------------------------------------
S
D
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
--
D
L
A
-
T
P
E
A
F
S
-----
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
----
Q
G
R
S
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
--
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
--
E
V
K
A
N
HKSPICPALDGKGAP
D
---
P
N
T
K
E
A
-------------------
R
I
P
V
E
L
L
--
P
R
C
ER
K
S
--
C
N
-----
G
-
L
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
--
K
C
-
D
L
C
L
V
V
G
T
S
------
S
I
V
-
Y
P
A
A
M
F
A
P
Q
----
V
A
S
R
--
G
V
P
V
A
E
F
N
---
M
E
C
T
P
A
T
Q
R
F
-----
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
47
PsiBlast_CBE
82.26
32%
-92
- C4 -
4UTX
6
SIR5_DANRE
A:
[12-271]
---------------------------------------------------------------------------------
D
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
--
D
L
A
-
T
P
E
A
F
S
-----
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
----
Q
G
R
S
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
--
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
--
E
V
K
A
N
HKSPICPALDGKGAP
D
---
P
N
T
K
E
A
-------------------
R
I
P
V
E
L
L
--
P
R
C
ER
K
S
--
C
N
-----
G
-
L
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
--
K
C
-
D
L
C
L
V
V
G
T
S
------
S
I
V
-
Y
P
A
A
M
F
A
P
Q
----
V
A
S
R
--
G
V
P
V
A
E
F
N
---
M
E
C
T
P
A
T
Q
-------
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
19
PsiBlast_PDB
82.18
32%
-89
- C4 -
4UTR
6
SIR5_DANRE
A:
[12-271]
---------------------------------------------------------------------------------
D
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
--
D
L
A
-
T
P
E
A
F
S
-----
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
----
Q
G
R
S
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
--
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
--
E
V
K
A
N
HKSPICPALDGKGAP
D
---
P
N
T
K
E
A
-------------------
R
I
P
V
E
L
L
--
P
R
C
ER
K
S
--
C
N
-----
G
-
L
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
--
K
C
-
D
L
C
L
V
V
G
T
S
------
S
I
V
-
Y
P
A
A
M
F
A
P
Q
----
V
A
S
R
--
G
V
P
V
A
E
F
N
---
M
E
C
T
P
A
T
Q
-------
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
45
PsiBlast_CBE
82.13
32%
-89
- C4 -
4UTZ
4
SIR5_DANRE
A:
[12-271]
---------------------------------------------------------------------------------
D
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
--
D
L
A
-
T
P
E
A
F
S
-----
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
----
Q
G
R
S
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
--
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
--
E
V
K
A
N
HKSPICPALDGKGAP
D
---
P
N
T
K
E
A
-------------------
R
I
P
V
E
L
L
--
P
R
C
ER
K
S
--
C
N
-----
G
-
L
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
--
K
C
-
D
L
C
L
V
V
G
T
S
------
S
I
V
-
Y
P
A
A
M
F
A
P
Q
----
V
A
S
R
--
G
V
P
V
A
E
F
N
---
M
E
C
T
P
A
T
Q
-------
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
50
PsiBlast_CBE
82.06
32%
-84
- C4 -
4UTN
4
SIR5_DANRE
B:
[11-271]
--------------------------------------------------------------------------------
S
D
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
--
D
L
A
-
T
P
E
A
F
S
-----
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
----
Q
G
R
S
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
--
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
--
E
V
K
A
N
HKSPICPALDGKGAP
D
---
P
N
T
K
E
A
-------------------
R
I
P
V
E
L
L
--
P
R
C
ER
K
S
--
C
N
-----
G
-
L
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
--
K
C
-
D
L
C
L
V
V
G
T
S
------
S
I
V
-
Y
P
A
A
M
F
A
P
Q
----
V
A
S
R
--
G
V
P
V
A
E
F
N
---
M
E
C
T
P
A
T
Q
R
F
-----
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
39
PsiBlast_CBE
82.00
32%
-90
- C4 -
4UUA
5
SIR5_DANRE
A:
[12-271]
---------------------------------------------------------------------------------
D
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
--
D
L
A
-
T
P
E
A
F
S
-----
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
----
Q
G
R
S
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
--
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
--
E
V
K
A
N
HKSPICPALDGKGAP
D
---
P
N
T
K
E
A
-------------------
R
I
P
V
E
L
L
--
P
R
C
ER
K
S
--
C
N
-----
G
-
L
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
--
K
C
-
D
L
C
L
V
V
G
T
S
------
S
I
V
-
Y
P
A
A
M
F
A
P
Q
----
V
A
S
R
--
G
V
P
V
A
E
F
N
---
M
E
C
T
P
A
T
Q
-------
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
41
PsiBlast_CBE
81.87
32%
-91
- C4 -
4UU8
4
SIR5_DANRE
A:
[12-271]
---------------------------------------------------------------------------------
D
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
--
D
L
A
-
T
P
E
A
F
S
-----
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
----
Q
G
R
S
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
--
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
--
E
V
K
A
N
HKSPICPALDGKGAP
D
---
P
N
T
K
E
A
-------------------
R
I
P
V
E
L
L
--
P
R
C
ER
K
S
--
C
N
-----
G
-
L
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
--
K
C
-
D
L
C
L
V
V
G
T
S
------
S
I
V
-
Y
P
A
A
M
F
A
P
Q
----
V
A
S
R
--
G
V
P
V
A
E
F
N
---
M
E
C
T
P
A
T
Q
-------
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
1
PsiBlast_PDB
81.78
34%
-88
- C4 -
1M2G
2
NPD1_ARCFU
A:
[7-242]
---------------------------------------------------------------------------------------
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
D
G
L
W
N
R
Y
R
P
E
--
E
L
A
-
N
P
Q
A
F
A
-----
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
E
K
V
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
----
L
E
R
----
L
G
V
L
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
S
--
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
---------------------------
N
N
S
F
E
V
-------------------
E
S
A
P
K
I
P
PL
P
K
C
--
D
K
--
C
G
-----
S
-
L
L
R
P
G
V
V
W
F
G
E
M
L
P
P
D
V
L
D
R
A
M
R
E
V
E
--
R
A
-
D
V
I
I
V
A
G
T
S
------
A
-------
V
V
Q
P
A
AS
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
---
P
D
E
T
P
L
T
P
I
A
-----
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
K
-----------------------------------
46
PsiBlast_CBE
81.77
32%
-90
- C4 -
4UTX
5
SIR5_DANRE
B:
[11-271]
--------------------------------------------------------------------------------
S
D
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
--
D
L
A
-
T
P
E
A
F
S
-----
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
----
Q
G
R
S
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
--
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
--
E
V
K
A
N
HKSPICPALDGKGAP
D
---
P
N
T
K
E
A
-------------------
R
I
P
V
E
L
L
--
P
R
C
ER
K
S
--
C
N
-----
G
-
L
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
--
K
C
-
D
L
C
L
V
V
G
T
S
------
S
I
V
-
Y
P
A
A
M
F
A
P
Q
----
V
A
S
R
--
G
V
P
V
A
E
F
N
---
M
E
C
------
F
-----
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
37
PsiBlast_CBE
81.62
32%
-91
- C4 -
4UUB
5
SIR5_DANRE
A:
[12-271]
---------------------------------------------------------------------------------
D
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
--
D
L
A
-
T
P
E
A
F
S
-----
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
----
Q
G
R
S
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
--
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
--
E
V
K
A
N
HKSPICPALDGKGAP
D
---
P
N
T
K
E
A
-------------------
R
I
P
V
E
L
L
--
P
R
C
ER
K
S
--
C
N
-----
G
-
L
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
--
K
C
-
D
L
C
L
V
V
G
T
S
------
S
I
V
-
Y
P
A
A
M
F
A
P
Q
----
V
A
S
R
--
G
V
P
V
A
E
F
N
---
M
E
C
T
P
A
T
Q
-------
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
35
PsiBlast_CBE
81.32
32%
-87
- C4 -
4HDA
3
SIR5_HUMAN
B:
[11-275]
--------------------------------------------------------------------------------
S
S
M
A
D
F
R
K
F
F
A
K
A
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
G
G
Y
W
R
K
W
Q
A
Q
--
D
L
A
-
T
P
L
A
F
A
-----
H
N
P
S
R
V
W
E
F
Y
H
Y
R
R
E
V
M
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
E
T
R
L
G
K
----
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
T
--
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
--
V
V
A
E
N
YKSPICPALSGKGAP
E
---
P
G
T
Q
D
A
-------------------
S
I
P
V
E
K
L
--
P
R
C
EE
A
G
--
C
G
-----
G
-
L
L
R
P
H
V
V
W
F
G
E
N
L
D
P
A
I
L
E
E
V
D
R
E
L
A
--
H
-
C
D
L
C
L
V
V
G
T
S
------
S
V
V
-
Y
P
A
A
M
F
A
P
Q
----
V
A
A
R
--
G
V
P
V
A
E
F
N
---
T
E
T
T
P
A
T
N
R
F
-----
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
A
---------------------------------------
48
PsiBlast_CBE
81.25
32%
-93
- C4 -
4UTV
4
SIR5_DANRE
B:
[11-271]
--------------------------------------------------------------------------------
S
D
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
--
D
L
A
-
T
P
E
A
F
S
-----
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
----
Q
G
R
S
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
--
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
--
E
V
K
A
N
HKSPICPALDGKGAP
D
---
P
N
T
K
E
A
-------------------
R
I
P
V
E
L
L
--
P
R
C
ER
K
S
--
C
N
-----
G
-
L
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
--
K
C
-
D
L
C
L
V
V
G
T
S
------
S
I
V
-
Y
P
A
A
M
F
A
P
Q
----
V
A
S
R
--
G
V
P
V
A
E
F
N
---
M
E
-------
F
-----
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
5
PsiBlast_PDB
81.18
34%
-86
- C4 -
1M2H
2
NPD1_ARCFU
A:
[7-242]
---------------------------------------------------------------------------------------
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
A
A
E
S
G
I
P
T
F
R
G
K
D
G
L
W
N
R
Y
R
P
E
--
E
L
A
-
N
P
Q
A
F
A
-----
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
E
K
V
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
----
L
E
R
----
L
G
V
L
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
S
--
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
---------------------------
N
N
S
F
E
V
-------------------
E
S
A
P
K
I
P
PL
P
K
C
--
D
K
--
C
G
-----
S
-
L
L
R
P
G
V
V
W
F
G
E
M
L
P
P
D
V
L
D
R
A
M
R
E
V
E
--
R
A
-
D
V
I
I
V
A
G
T
S
------
A
-------
V
V
Q
P
A
AS
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
---
P
D
E
T
P
L
T
P
I
A
-----
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
K
-----------------------------------
20
PsiBlast_PDB
81.07
32%
-92
- C4 -
4UTV
4
SIR5_DANRE
A:
[12-271]
---------------------------------------------------------------------------------
D
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
--
D
L
A
-
T
P
E
A
F
S
-----
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
----
Q
G
R
S
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
--
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
--
E
V
K
A
N
HKSPICPALDGKGAP
D
---
P
N
T
K
E
A
-------------------
R
I
P
V
E
L
L
--
P
R
C
ER
K
S
--
C
N
-----
G
-
L
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
--
K
C
-
D
L
C
L
V
V
G
T
S
------
S
I
V
-
Y
P
A
A
M
F
A
P
Q
----
V
A
S
R
--
G
V
P
V
A
E
F
N
---
M
E
C
------------
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
44
PsiBlast_CBE
81.03
32%
-91
- C4 -
4UTZ
5
SIR5_DANRE
B:
[11-271]
--------------------------------------------------------------------------------
S
D
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
--
D
L
A
-
T
P
E
A
F
S
-----
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
----
Q
G
R
S
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
--
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
--
E
V
K
A
N
HKSPICPALDGKGAP
D
---
P
N
T
K
E
A
-------------------
R
I
P
V
E
L
L
--
P
R
C
ER
K
S
--
C
N
-----
G
-
L
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
--
K
C
-
D
L
C
L
V
V
G
T
S
------
S
I
V
-
Y
P
A
A
M
F
A
P
Q
----
V
A
S
R
--
G
V
P
V
A
E
F
N
---
M
E
C
T
-----
F
-----
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
4
PsiBlast_PDB
80.63
34%
-84
- C4 -
1M2N
2
NPD1_ARCFU
A:
[7-242]
---------------------------------------------------------------------------------------
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
D
G
L
W
N
R
Y
R
P
E
--
E
L
A
-
N
P
Q
A
F
A
-----
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
E
K
V
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
----
L
E
R
----
L
G
V
L
K
C
L
I
T
Q
N
V
D
G
L
H
E
R
A
G
S
--
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
---------------------------
N
N
S
F
E
V
-------------------
E
S
A
P
K
I
P
PL
P
K
C
--
D
K
--
C
G
-----
S
-
L
L
R
P
G
V
V
W
A
G
E
M
L
P
P
D
V
L
D
A
A
M
R
E
V
E
--
R
A
-
D
V
I
I
V
A
G
T
S
------
A
-------
V
V
Q
P
A
AS
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
---
P
D
E
T
P
L
T
P
I
A
-----
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
K
-----------------------------------
40
PsiBlast_CBE
80.45
32%
-86
- C4 -
4UU8
5
SIR5_DANRE
B:
[11-271]
--------------------------------------------------------------------------------
S
D
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
--
D
L
A
-
T
P
E
A
F
S
-----
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
----
Q
G
R
S
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
--
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
--
E
V
K
A
N
HKSPICPALDGKGAP
D
---
P
N
T
K
E
A
-------------------
R
I
P
V
E
L
L
--
P
R
C
ER
K
S
--
C
N
-----
G
-
L
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
--
K
C
-
D
L
C
L
V
V
G
T
S
------
S
I
V
-
Y
P
A
A
M
F
A
P
Q
----
V
A
S
R
--
G
V
P
V
A
E
F
N
---
M
E
C
T
P
A
T
Q
R
F
-----
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
42
PsiBlast_CBE
80.30
32%
-84
- C4 -
4UU7
5
SIR5_DANRE
B:
[11-271]
--------------------------------------------------------------------------------
S
D
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
--
D
L
A
-
T
P
E
A
F
S
-----
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
----
Q
G
R
S
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
--
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
--
E
V
K
A
N
HKSPICPALDGKGAP
D
---
P
N
T
K
E
A
-------------------
R
I
P
V
E
L
L
--
P
R
C
ER
K
S
--
C
N
-----
G
-
L
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
--
K
C
-
D
L
C
L
V
V
G
T
S
------
S
I
V
-
Y
P
A
A
M
F
A
P
Q
----
V
A
S
R
--
G
V
P
V
A
E
F
N
---
M
E
C
T
P
A
T
Q
R
F
-----
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
7
PsiBlast_PDB
79.89
34%
-84
- C4 -
1M2K
2
NPD1_ARCFU
A:
[7-242]
---------------------------------------------------------------------------------------
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
D
G
L
W
N
R
Y
R
P
E
--
E
L
A
-
N
P
Q
A
F
A
-----
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
E
K
V
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
----
L
E
R
----
L
G
V
L
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
S
--
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
---------------------------
N
N
S
F
E
V
-------------------
E
S
A
P
K
I
P
PL
P
K
C
--
D
K
--
C
G
-----
S
-
L
L
R
P
G
V
V
W
A
G
E
M
L
P
P
D
V
L
D
R
A
M
R
E
V
E
--
R
A
-
D
V
I
I
V
A
G
T
S
------
A
-------
V
V
Q
P
A
AS
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
---
P
D
E
T
P
L
T
P
I
A
-----
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
K
-----------------------------------
36
PsiBlast_CBE
79.84
32%
-91
- C4 -
4UUB
5
SIR5_DANRE
B:
[11-271]
--------------------------------------------------------------------------------
S
D
L
T
A
F
R
E
H
F
A
K
A
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
P
G
G
F
W
R
K
W
Q
A
Q
--
D
L
A
-
T
P
E
A
F
S
-----
R
D
P
S
L
V
W
E
F
Y
H
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
----
Q
G
R
S
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
S
--
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
--
E
V
K
A
N
HKSPICPALDGKGAP
D
---
P
N
T
K
E
A
-------------------
R
I
P
V
E
L
L
--
P
R
C
ER
K
S
--
C
N
-----
G
-
L
L
R
P
H
V
V
W
F
G
E
T
L
D
S
D
I
L
T
A
V
E
R
E
L
E
--
K
C
-
D
L
C
L
V
V
G
T
S
------
S
I
V
-
Y
P
A
A
M
F
A
P
Q
----
V
A
S
R
--
G
V
P
V
A
E
F
N
---
M
E
C
T
P
A
---
F
-----
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------------------------------------
22
PsiBlast_CBE
79.13
34%
-83
- C4 -
1M2N
2
NPD1_ARCFU
B:
[7-242]
---------------------------------------------------------------------------------------
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
D
G
L
W
N
R
Y
R
P
E
--
E
L
A
-
N
P
Q
A
F
A
-----
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
E
K
V
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
----
L
E
R
----
L
G
V
L
K
C
L
I
T
Q
N
V
D
G
L
H
E
R
A
G
S
--
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
---------------------------
N
N
S
F
E
V
-------------------
E
S
A
P
K
I
P
PL
P
K
C
--
D
K
--
C
G
-----
S
-
L
L
R
P
G
V
V
W
A
G
E
M
L
P
P
D
V
L
D
A
A
M
R
E
V
E
--
R
A
-
D
V
I
I
V
A
G
T
S
------
A
-------
V
V
Q
P
A
ASLP
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
---
P
D
E
T
P
L
T
P
I
A
-----
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
K
-----------------------------------