@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA1256: (2016-01-27 )
MIEINDVHKAYGQFEVVKGVDLRVDKGEVLSIIGGSGSGKSTLLMCINGLEPIQRGSIRVDGIDVHARGTDLNRLRRKIGIVFQQWNAFPHLTVLENVMLAPRKVLGKSRAEAEAMALKQLTHVGLGDKLKVFPQRLSGGQQQRMAIARALAMSPDYMLFDEATSALDPQLVGEVLDTMRLLAEEGMTMVLVTHEIRFARDVSDRVAFFRNGLVHEIGPPDQVIGNPQRPETVEFLRSVL
Atome Classification :
(21 SA)
-.........10.-.......20........30........40........50---.........60.-------------....-----------..-----------.70........80........90........100.......110.......120----------.......130-........140.......150.-......160.......170.......180.......190.......200.......-210.......220.......-230.......240--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MIE
I
N
D
V
H
K
AYG-Q
F
E
V
V
K
G
V
D
L
R
VDKG
E
V
L
S
I
IGGSGSG
K
S
T
L
L
M
C
INGL----EPIQRG
S
I
R
V
D
G
-------------
I
D
V
H-----------AR-----------GT
D
L
N
R
L
R
R
K
I
G
I
V
F
Q
QWNAFP
H
L
T
V
L
E
N
V
ML
A
P
R
K
V
LGKSR
A
E
A
E
A
M
A
L
K
Q
L
T
----------HVGLG
D
K
L
-
K
-
V
F
P
Q
RLSG
G
Q
Q
Q
R
M
A
I
A
R
A
LAM-SPD
Y
M
L
FDEATSAL
D
P
Q
L
V
G
E
V
L
D
T
M
R
L
L
A
EEG
M
T
M
V
L
V
T
H
E
I
R
FAR
D
V
S
D
R
V
A
F
F
-RNGLVHEIG
P
P
D
QVIGNPQR-P
E
T
V
E
F
L
R
S
VL----
12
PsiBlast_PDB
95.51
54%
-120
- C1 -
4U00
3
?
A:
[4-242]
-
I
I
R
I
R
N
L
H
K
W
F
G
-
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
----
E
D
F
Q
E
G
E
V
V
V
D
G
-------------
L
S
V
K
-----------
D
------------
D
R
A
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
----------
R
V
G
I
L
D
Q
A
-
R
-
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
-
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
-
E
R
T
R
S
F
L
Q
R
V
L
----
133
HHSearch
95.25
55%
-121
- C1 -
1B0U
4
HISP_SALTY
A:
[7-254]
--
L
H
V
I
D
L
H
K
R
Y
G
-
G
H
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
----
E
K
P
S
E
G
A
I
I
V
N
G
-------------
Q
N
I
N
-----------
L
V
R
D
KDGQLKVAD
K
N
Q
L
R
L
L
R
T
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
I
Q
V
L
G
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
----------
K
V
G
I
D
E
R
A
Q
G
-
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
-
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
-
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
-
P
R
L
Q
Q
F
L
K
G
S
L
----
35
PsiBlast_CBE
94.58
54%
-119
- C1 -
4U02
1
?
B:
[4-242]
-
I
I
R
I
R
N
L
H
K
W
F
G
-
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
----
E
D
F
Q
E
G
E
V
V
V
D
G
-------------
L
S
V
K
-----------
D
------------
D
R
A
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
----------
R
V
G
I
L
D
Q
A
-
R
-
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
-
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
-
E
R
T
R
S
F
L
Q
R
V
L
----
34
PsiBlast_CBE
94.58
54%
-116
- C1 -
4U02
1
?
C:
[4-242]
-
I
I
R
I
R
N
L
H
K
W
F
G
-
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
----
E
D
F
Q
E
G
E
V
V
V
D
G
-------------
L
S
V
K
-----------
D
------------
D
R
A
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
----------
R
V
G
I
L
D
Q
A
-
R
-
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
-
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
-
E
R
T
R
S
F
L
Q
R
V
L
----
13
PsiBlast_PDB
94.08
54%
-117
- C1 -
4U02
1
?
A:
[4-242]
-
I
I
R
I
R
N
L
H
K
W
F
G
-
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
----
E
D
F
Q
E
G
E
V
V
V
D
G
-------------
L
S
V
K
-----------
D
------------
D
R
A
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
----------
R
V
G
I
L
D
Q
A
-
R
-
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
-
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
-
E
R
T
R
S
F
L
Q
R
V
L
----
11
PsiBlast_PDB
93.58
52%
-118
- C1 -
3C4J
3
?
A:
[24-263]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
-----------
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
----------
K
V
G
L
K
D
K
A
-
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
K
V
F
----
31
PsiBlast_CBE
93.32
52%
-121
- C1 -
2OLK
2
?
B:
[24-263]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
-----------
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
----------
K
V
G
L
K
D
K
A
-
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
K
V
F
----
33
PsiBlast_CBE
92.96
54%
-117
- C1 -
4U02
1
?
D:
[4-242]
-
I
I
R
I
R
N
L
H
K
W
F
G
-
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
----
E
D
F
Q
E
G
E
V
V
V
D
G
-------------
L
S
V
K
-----------
D
------------
D
R
A
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
----------
R
V
G
I
L
D
Q
A
-
R
-
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
-
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
-
E
R
T
R
S
F
L
Q
R
V
L
----
23
PsiBlast_CBE
92.82
52%
-123
- C1 -
3C41
3
?
K:
[3-242]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
-----------
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
----------
K
V
G
L
K
D
K
A
-
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
K
V
F
----
14
PsiBlast_PDB
92.68
52%
-120
- C1 -
1B0U
4
HISP_SALTY
A:
[7-257]
--
L
H
V
I
D
L
H
K
R
Y
G
-
G
H
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
----
E
K
P
S
E
G
A
I
I
V
N
G
-------------
Q
N
I
N
L
V
R
D
KDGQLKV
A
D
-----------
K
N
Q
L
R
L
L
R
T
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
I
Q
V
L
G
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
----------
K
V
G
I
D
E
R
A
-
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
-
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
-
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
-
P
R
L
Q
Q
F
L
K
G
S
L
----
24
PsiBlast_CBE
92.61
52%
-124
- C1 -
3C4J
4
?
B:
[24-263]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
-----------
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
----------
K
V
G
L
K
D
K
A
-
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
K
V
F
----
29
PsiBlast_CBE
92.26
52%
-117
- C1 -
2OLK
1
?
D:
[24-263]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
-----------
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
----------
K
V
G
L
K
D
K
A
-
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
K
V
F
----
2
PsiBlast_PDB
92.21
54%
-121
- C1 -
4YMT
-
?
J:
[1-240]
-
M
I
F
V
N
D
V
Y
K
N
F
G
-
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
----
E
E
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
N
-----------
N
G
-----------
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
----------
K
V
G
L
L
D
K
K
-
D
-
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
-
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
-
E
R
T
R
E
F
L
S
K
I
L
----
3
PsiBlast_PDB
92.19
54%
-119
- C1 -
4YMU
2
?
J:
[1-240]
-
M
I
F
V
N
D
V
Y
K
N
F
G
-
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
----
E
E
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
N
-----------
N
G
-----------
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
----------
K
V
G
L
L
D
K
K
-
D
-
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
-
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
-
E
R
T
R
E
F
L
S
K
I
L
----
132
HHSearch
92.14
53%
-120
- C1 -
2OLJ
4
?
A:
[24-262]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
-----------
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
----------
K
V
G
L
K
D
K
A
-
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
K
V
F
----
9
PsiBlast_PDB
91.71
52%
-124
- C1 -
2OUK
1
?
A:
[24-263]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
-----------
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
----------
K
V
G
L
K
D
K
A
-
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
K
V
F
----
7
PsiBlast_PDB
91.71
52%
-121
- C1 -
2OLJ
4
?
A:
[24-263]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
-----------
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
----------
K
V
G
L
K
D
K
A
-
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
K
V
F
----
8
PsiBlast_PDB
91.49
52%
-121
- C1 -
2OLK
1
?
A:
[24-263]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
-----------
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
----------
K
V
G
L
K
D
K
A
-
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
K
V
F
----
21
PsiBlast_CBE
91.39
54%
-120
- C1 -
4YMV
1
?
A:
[1-240]
-
M
I
F
V
N
D
V
Y
K
N
F
G
-
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
----
E
E
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
N
-----------
N
G
-----------
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
----------
K
V
G
L
L
D
K
K
-
D
-
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
-
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
-
E
R
T
R
E
F
L
S
K
I
L
----
22
PsiBlast_CBE
91.29
54%
-122
- C1 -
4YMU
2
?
A:
[1-240]
-
M
I
F
V
N
D
V
Y
K
N
F
G
-
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
----
E
E
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
N
-----------
N
G
-----------
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
----------
K
V
G
L
L
D
K
K
-
D
-
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
-
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
-
E
R
T
R
E
F
L
S
K
I
L
----
116
Fugue
85.08
55%
-127
- C1 -
1B0U
4
HISP_SALTY
A:
[5-261]
N
K
L
H
V
I
D
L
H
K
R
Y
G
G
H
E
V
L
K
-
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
EKPS----
E
G
A
I
I
V
N
G
QNI
N
L
V
R
D
KDGQL
K
V
A
D
-----------
K
N
-----------
Q
L
R
L
L
R
T
-
R
-
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
I
Q
V
L
G
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
GIDERAQG-----------
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E-
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
-
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
-
Q
S
P
R
L
Q
Q
F
L
K
G
S
L
K
KLE