@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA1279: (2016-01-28 )
MSLQWWRDTCREADPQMRRRAAERQDRLTKPRGSLGRLEQVAIDLAALQGRERPSLERIWVTVFAGDHGVVAEGISAYPQAVTGEMLRNFVRGGAAISVLARELGAGLEVVDLGTAFPLEALPGVRHLRLAAGTANFVEAPAMGAEECLLALEAGRESVRRAEQAGSQLFIGGEMGIGNTTAAAAMACALLDAPASALVGPGTGLDASGVAHKAAVIERALALHGAHRADPFETLRRLGGLEIAALAGAYLACAQKGMVALVDGYICSVAALCAVRLNPACRDWLLFAHSGAEPGHRHVLEALAAQPLLDLGLRLGEGSGAALAVPLLRQACALHAGMATFAEAAVSDRPA
Atome Classification :
(31 SA)
.........10........20........30........40........50.-.......60........70........80........90.........100.......110.......120.......130.......140..--.....150.......160.......170.......180.......190.......200.......210.......220-.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330-.......340.......350
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
L
Q
W
W
R
D
T
C
REA
D
P
Q
M
R
R
R
A
A
E
R
Q
D
RLTKPRGSLG
R
L
E
Q
V
A
I
D
L
A
A
LQGRE-RPS
L
E
R
I
W
V
T
V
F
AGDH
G
V
V
A
E
G
I
S
AY
P
Q
A
V
T
G
E
M
L
R
N
F
-
V
RG
G
A
A
I
S
V
L
A
R
E
LGAG
L
E
V
V
DLGTAF
P
L
E
ALPGV
R
H
L
R
LAAGTANFVEAPAM
G
--
A
E
E
C
L
L
A
L
E
A
G
R
E
S
V
R
R
A
E
QAGS
Q
L
F
IGGEMGIG
N
T
T
A
A
A
A
M
A
C
A
L
LDAP
A
S
ALVGPGTGLDASG
V
A
H
K
A
A
V
I
E
R
A
L
A
-LHGAHRA
D
P
F
E
T
L
R
R
LGGL
E
I
A
A
L
A
G
A
Y
L
A
C
A
QKGM
V
A
L
V
D
G
Y
I
C
S
V
A
A
L
C
A
VRLNP
A
C
R
D
W
L
L
F
AHSGAEP
G
H
R
H
V
L
E
A
L
A
AQ
P
L
L
D
L
G
LRLGEGSG
A
A
L
A
V
P
L
L
R
Q
A
C
-
A
L
H
A
G
M
A
T
F
A
E
A
AVSDRPA
45
HHSearch
94.27
50%
-118
- C7 -
1WX1
1
COBT_THET8
A:
[1-335]
------------
M
D
P
E
V
F
A
Q
A
R
L
R
M
D
Q
L
T
K
P
P
R
A
L
G
Y
L
E
E
V
A
L
R
L
A
A
L
Q
G
R
V
-
K
P
E
L
G
R
G
A
V
V
V
A
A
A
D
H
G
V
V
A
E
G
V
S
A
Y
P
Q
E
V
T
R
Q
M
V
L
N
F
-
L
R
G
G
A
A
I
N
Q
F
A
L
A
A
D
C
A
V
Y
V
L
D
V
G
V
V
G
E
L
P
D
H
P
G
L
L
K
R
K
V
R
P
G
T
A
N
L
A
Q
G
P
A
M
T
--
P
E
E
A
E
R
A
L
L
A
G
R
E
A
A
R
R
A
I
A
E
G
A
T
L
L
A
A
G
D
M
G
I
G
N
T
T
A
A
A
A
L
T
A
A
L
L
G
L
P
P
E
A
V
V
G
-----
G
E
E
G
L
R
R
K
R
Q
A
V
A
R
A
L
A
-
R
L
H
P
-
G
M
G
P
L
E
V
A
A
E
V
G
G
L
E
L
V
A
I
A
G
I
Y
L
E
G
Y
E
A
G
L
P
L
V
L
D
G
F
P
V
T
A
G
A
L
L
A
W
K
M
A
P
G
L
R
D
H
L
F
A
G
H
L
S
R
E
P
G
H
R
H
Q
L
E
A
L
G
L
R
P
L
L
D
L
D
L
A
L
G
E
G
T
G
A
V
L
A
M
P
L
L
R
A
A
A
-
R
I
L
-
H
M
A
T
F
Q
E
A
G
V
S
R
G
--
1
PsiBlast_PDB
93.86
50%
-120
- C7 -
1WX1
1
COBT_THET8
A:
[2-333]
-------------
D
P
E
V
F
A
Q
A
R
L
R
M
D
Q
L
T
K
P
P
R
A
L
G
Y
L
E
E
V
A
L
R
L
A
A
L
Q
G
R
V
-
K
P
E
L
G
R
G
A
V
V
V
A
A
A
D
H
G
V
V
A
E
G
V
S
A
Y
P
Q
E
V
T
R
Q
M
V
L
N
F
-
L
R
G
G
A
A
I
N
Q
F
A
L
A
A
D
C
A
V
Y
V
L
D
V
G
V
V
G
E
L
P
D
H
P
G
L
L
K
R
K
V
R
P
G
T
A
N
L
A
Q
G
P
A
M
T
--
P
E
E
A
E
R
A
L
L
A
G
R
E
A
A
R
R
A
I
A
E
G
A
T
L
L
A
A
G
D
M
G
I
G
N
T
T
A
A
A
A
L
T
A
A
L
L
G
L
P
P
E
A
V
V
G
-----
G
E
E
G
L
R
R
K
R
Q
A
V
A
R
A
L
A
R
L
H
P
G
--
M
G
P
L
E
V
A
A
E
V
G
G
L
E
L
V
A
I
A
G
I
Y
L
E
G
Y
E
A
G
L
P
L
V
L
D
G
F
P
V
T
A
G
A
L
L
A
W
K
M
A
P
G
L
R
D
H
L
F
A
G
H
L
S
R
E
P
G
H
R
H
Q
L
E
A
L
G
L
R
P
L
L
D
L
D
L
A
L
G
E
G
T
G
A
V
L
A
M
P
L
L
R
A
A
A
R
I
L
H
--
M
A
T
F
Q
E
A
G
V
S
R
G
--
4
PsiBlast_PDB
93.76
39%
-111
- C7 -
4KQK
7
COBT_SALTY
A:
[15-346]
-------------
D
A
E
A
M
A
R
A
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
Y
P
K
I
V
T
A
I
M
A
A
N
M
-
T
R
G
T
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
--
I
D
A
E
P
I
P
G
V
V
N
M
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
-
L
E
V
S
R
Y
T
C
D
L
A
-
Q
R
G
V
T
L
F
G
V
G
E
M
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
-
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
-
A
M
F
H
N
M
G
E
L
A
A
S
N
I
V
L
P
--
3
PsiBlast_PDB
92.84
39%
-112
- C7 -
4KQJ
3
COBT_SALTY
A:
[15-346]
-------------
D
A
E
A
M
A
R
A
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
Y
P
K
I
V
T
A
I
M
A
A
N
M
-
T
R
G
T
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
--
I
D
A
E
P
I
P
G
V
V
N
M
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
-
L
E
V
S
R
Y
T
C
D
L
A
-
Q
R
G
V
T
L
F
G
V
G
E
M
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
-
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
-
A
M
F
H
N
M
G
E
L
A
A
S
N
I
V
L
P
--
2
PsiBlast_PDB
92.41
50%
-116
- C7 -
1J33
-
COBT_THET8
A:
[3-333]
--------------
P
E
V
F
A
Q
A
R
L
R
M
D
Q
L
T
K
P
P
R
A
L
G
Y
L
E
E
V
A
L
R
L
A
A
L
Q
G
R
V
-
K
P
E
L
G
R
G
A
V
V
V
A
A
A
D
H
G
V
V
A
E
G
V
S
A
Y
P
Q
E
V
T
R
Q
M
V
L
N
F
-
L
R
G
G
A
A
I
N
Q
F
A
L
A
A
D
C
A
V
Y
V
L
D
V
G
V
V
G
E
L
P
D
H
P
G
L
L
K
R
K
V
R
P
G
T
A
N
L
A
Q
G
P
A
M
T
--
P
E
E
A
E
R
A
L
L
A
G
R
E
A
A
R
R
A
I
A
E
G
A
T
L
L
A
A
G
D
M
G
I
G
N
T
T
A
A
A
A
L
T
A
A
L
L
G
L
P
P
E
A
V
V
G
R
G
T
G
V
G
E
E
G
L
R
R
K
R
Q
A
V
A
R
A
L
A
R
L
H
P
G
--
M
G
P
L
E
V
A
A
E
V
G
G
I
E
L
V
A
I
A
G
I
Y
L
E
G
Y
E
A
G
L
P
L
V
L
D
G
F
P
V
T
A
G
A
L
L
A
W
K
M
A
P
G
L
R
D
H
L
F
A
G
H
L
S
R
E
P
G
H
R
H
Q
L
E
A
L
G
L
R
P
L
L
D
L
D
L
A
L
G
E
G
T
G
A
V
L
A
M
P
L
L
R
A
A
A
R
I
L
H
--
M
A
T
F
Q
E
A
G
V
S
R
G
--
13
PsiBlast_PDB
91.33
38%
-110
- C7 -
1JHX
3
COBT_SALTY
A:
[15-346]
-------------
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
M
-
T
R
G
T
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
--
I
D
A
E
P
I
P
G
V
V
N
M
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
-
L
E
V
S
R
Y
T
C
D
L
A
-
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
-
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
-
A
M
F
H
N
M
G
E
L
A
A
S
N
I
V
L
P
--
56
Fugue
91.30
35%
-110
- C7 -
1JHU
3
COBT_SALTY
A:
[4-349]
--
L
H
A
L
L
R
D
I
P
A
P
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
M
-
T
R
G
T
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
--
I
D
A
E
P
I
P
G
V
V
N
M
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
--
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
T
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
-
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
-
A
M
F
H
N
M
G
E
L
A
A
S
N
I
V
L
P
--
22
PsiBlast_CBE
90.97
38%
-110
- C7 -
1L5N
2
COBT_SALTY
A:
[15-346]
-------------
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
M
-
T
R
G
T
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
--
I
D
A
E
P
I
P
G
V
V
N
M
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
-
L
E
V
S
R
Y
T
C
D
L
A
-
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
-
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
-
A
M
F
H
N
M
G
E
L
A
A
S
N
I
V
L
P
--
55
Fugue
90.90
35%
-108
- C7 -
1JH8
3
COBT_SALTY
A:
[3-350]
-
T
L
H
A
L
L
R
D
I
P
A
P
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
M
-
T
R
G
T
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
--
I
D
A
E
P
I
P
G
V
V
N
M
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
--
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
T
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
-
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
-
A
M
F
H
N
M
G
E
L
A
A
S
N
I
V
L
P
E
-
7
PsiBlast_PDB
90.85
38%
-110
- C7 -
1JHM
3
COBT_SALTY
A:
[15-346]
-------------
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
M
-
T
R
G
T
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
--
I
D
A
E
P
I
P
G
V
V
N
M
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
-
L
E
V
S
R
Y
T
C
D
L
A
-
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
-
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
-
A
M
F
H
N
M
G
E
L
A
A
S
N
I
V
L
P
--
25
PsiBlast_CBE
90.73
38%
-111
- C7 -
1L5F
3
COBT_SALTY
A:
[15-346]
-------------
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
M
-
T
R
G
T
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
--
I
D
A
E
P
I
P
G
V
V
N
M
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
-
L
E
V
S
R
Y
T
C
D
L
A
-
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
-
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
-
A
M
F
H
N
M
G
E
L
A
A
S
N
I
V
L
P
--
26
PsiBlast_CBE
90.72
38%
-113
- C7 -
1L4N
3
COBT_SALTY
A:
[15-346]
-------------
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
M
-
T
R
G
T
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
--
I
D
A
E
P
I
P
G
V
V
N
M
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
-
L
E
V
S
R
Y
T
C
D
L
A
-
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
-
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
-
A
M
F
H
N
M
G
E
L
A
A
S
N
I
V
L
P
--
14
PsiBlast_PDB
90.69
38%
-112
- C7 -
1JHY
3
COBT_SALTY
A:
[15-346]
-------------
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
M
-
T
R
G
T
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
--
I
D
A
E
P
I
P
G
V
V
N
M
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
-
L
E
V
S
R
Y
T
C
D
L
A
-
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
-
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
-
A
M
F
H
N
M
G
E
L
A
A
S
N
I
V
L
P
--
12
PsiBlast_PDB
90.67
38%
-110
- C7 -
1JHV
3
COBT_SALTY
A:
[15-346]
-------------
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
M
-
T
R
G
T
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
--
I
D
A
E
P
I
P
G
V
V
N
M
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
-
L
E
V
S
R
Y
T
C
D
L
A
-
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
-
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
-
A
M
F
H
N
M
G
E
L
A
A
S
N
I
V
L
P
--
18
PsiBlast_PDB
90.65
38%
-111
- C7 -
1L4G
2
COBT_SALTY
A:
[15-346]
-------------
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
M
-
T
R
G
T
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
--
I
D
A
E
P
I
P
G
V
V
N
M
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
-
L
E
V
S
R
Y
T
C
D
L
A
-
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
-
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
-
A
M
F
H
N
M
G
E
L
A
A
S
N
I
V
L
P
--
16
PsiBlast_PDB
90.56
38%
-111
- C7 -
1L4E
1
COBT_SALTY
A:
[15-346]
-------------
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
M
-
T
R
G
T
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
--
I
D
A
E
P
I
P
G
V
V
N
M
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
-
L
E
V
S
R
Y
T
C
D
L
A
-
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
-
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
-
A
M
F
H
N
M
G
E
L
A
A
S
N
I
V
L
P
--
57
Fugue
90.43
35%
-111
* C7 *
1D0V
2
COBT_SALTY
A:
[4-349]
--
L
H
A
L
L
R
D
I
P
A
P
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
M
-
T
R
G
T
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
--
I
D
A
E
P
I
P
G
V
V
N
M
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
--
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
A
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
-
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
-
A
M
F
H
N
M
G
E
L
A
A
S
N
I
V
L
P
--
21
PsiBlast_CBE
90.43
38%
-109
- C7 -
1L5O
2
COBT_SALTY
A:
[15-346]
-------------
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
M
-
T
R
G
T
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
--
I
D
A
E
P
I
P
G
V
V
N
M
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
-
L
E
V
S
R
Y
T
C
D
L
A
-
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
-
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
-
A
M
F
H
N
M
G
E
L
A
A
S
N
I
V
L
P
--
11
PsiBlast_PDB
90.40
38%
-110
- C7 -
1JHU
3
COBT_SALTY
A:
[15-346]
-------------
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
M
-
T
R
G
T
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
--
I
D
A
E
P
I
P
G
V
V
N
M
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
-
L
E
V
S
R
Y
T
C
D
L
A
-
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
-
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
-
A
M
F
H
N
M
G
E
L
A
A
S
N
I
V
L
P
--
23
PsiBlast_CBE
90.33
38%
-110
- C7 -
1L5L
2
COBT_SALTY
A:
[15-346]
-------------
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
M
-
T
R
G
T
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
--
I
D
A
E
P
I
P
G
V
V
N
M
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
-
L
E
V
S
R
Y
T
C
D
L
A
-
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
-
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
-
A
M
F
H
N
M
G
E
L
A
A
S
N
I
V
L
P
--
10
PsiBlast_PDB
90.24
38%
-111
- C7 -
1JHQ
2
COBT_SALTY
A:
[15-346]
-------------
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
M
-
T
R
G
T
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
--
I
D
A
E
P
I
P
G
V
V
N
M
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
-
L
E
V
S
R
Y
T
C
D
L
A
-
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
-
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
-
A
M
F
H
N
M
G
E
L
A
A
S
N
I
V
L
P
--
6
PsiBlast_PDB
90.22
38%
-110
- C7 -
1JHA
2
COBT_SALTY
A:
[15-346]
-------------
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
M
-
T
R
G
T
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
--
I
D
A
E
P
I
P
G
V
V
N
M
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
-
L
E
V
S
R
Y
T
C
D
L
A
-
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
-
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
-
A
M
F
H
N
M
G
E
L
A
A
S
N
I
V
L
P
--
8
PsiBlast_PDB
90.16
38%
-111
- C7 -
1JHO
2
COBT_SALTY
A:
[15-346]
-------------
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
M
-
T
R
G
T
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
--
I
D
A
E
P
I
P
G
V
V
N
M
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
-
L
E
V
S
R
Y
T
C
D
L
A
-
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
-
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
-
A
M
F
H
N
M
G
E
L
A
A
S
N
I
V
L
P
--
24
PsiBlast_CBE
89.76
38%
-111
- C7 -
1L5K
2
COBT_SALTY
A:
[15-346]
-------------
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
M
-
T
R
G
T
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
--
I
D
A
E
P
I
P
G
V
V
N
M
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
-
L
E
V
S
R
Y
T
C
D
L
A
-
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
-
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
-
A
M
F
H
N
M
G
E
L
A
A
S
N
I
V
L
P
--
29
PsiBlast_CBE
89.67
38%
-111
- C7 -
1D0V
2
COBT_SALTY
A:
[15-346]
-------------
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
M
-
T
R
G
T
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
--
I
D
A
E
P
I
P
G
V
V
N
M
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
-
L
E
V
S
R
Y
A
C
D
L
A
-
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
-
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
-
A
M
F
H
N
M
G
E
L
A
A
S
N
I
V
L
P
--
31
PsiBlast_CBE
89.11
38%
-113
- C7 -
4KQI
3
COBT_SALTY
A:
[15-342]
-------------
D
A
E
A
M
A
R
A
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
M
-
T
R
G
T
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
--
I
D
A
E
P
I
P
G
V
V
N
M
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
-
L
E
V
S
R
Y
T
C
D
L
A
-
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
-
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
A
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
-
A
M
F
H
N
M
G
E
L
A
---------
36
PsiBlast_CBE
87.56
34%
-113
- C7 -
4HDR
5
?
C:
[17-338]
-------------
D
T
V
I
K
D
Q
V
K
T
K
L
A
G
V
L
Q
S
A
G
S
L
G
R
L
E
D
M
V
E
Q
Y
A
G
I
T
G
E
L
-
N
P
A
L
P
K
P
C
M
V
V
A
S
A
D
H
G
V
A
R
R
V
V
S
A
Y
P
I
E
T
T
I
H
M
T
A
N
Y
L
I
S
Q
G
A
S
A
N
A
F
A
N
F
C
G
A
D
M
V
V
V
D
M
G
V
A
G
D
L
S
Y
V
P
G
L
W
H
R
K
I
A
Y
G
T
Q
D
F
T
E
G
P
A
M
T
--
R
E
Q
A
I
Q
A
V
E
T
G
I
D
I
V
N
D
R
V
K
H
G
N
R
C
F
C
L
G
E
M
G
I
G
N
T
T
S
S
A
T
I
V
G
A
F
T
G
L
A
P
E
K
V
T
G
R
G
-------
L
K
T
K
M
E
I
V
G
R
A
L
A
-
V
N
K
P
N
P
Q
D
G
L
D
V
L
A
K
V
G
G
F
E
L
G
A
L
A
G
V
I
L
G
S
A
A
N
R
C
A
V
V
I
D
G
L
N
T
T
A
A
A
L
I
A
N
V
I
H
P
L
S
K
E
Y
M
F
A
S
H
L
S
G
E
P
A
H
S
I
A
L
R
Q
L
Q
L
E
A
C
L
E
L
G
V
R
L
G
E
G
I
G
A
S
M
V
V
D
M
L
Y
V
A
I
-
K
L
L
N
N
--------------
38
PsiBlast_CBE
87.38
34%
-112
- C7 -
4HDM
2
?
A:
[17-338]
-------------
D
T
V
I
K
D
Q
V
K
T
K
L
A
G
V
L
Q
S
A
G
S
L
G
R
L
E
D
M
V
E
Q
Y
A
G
I
T
G
E
L
-
N
P
A
L
P
K
P
C
M
V
V
A
S
A
D
H
G
V
A
R
R
V
V
S
A
Y
P
I
E
T
T
I
H
M
T
A
N
Y
L
I
S
Q
G
A
S
A
N
A
F
A
N
F
C
G
A
D
M
V
V
V
D
M
G
V
A
G
D
L
S
Y
V
P
G
L
W
H
R
K
I
A
Y
G
T
Q
D
F
T
E
G
P
A
M
T
--
R
E
Q
A
I
Q
A
V
E
T
G
I
D
I
V
N
D
R
V
K
H
G
N
R
C
F
C
L
G
E
M
G
I
G
N
T
T
S
S
A
T
I
V
G
A
F
T
G
L
A
P
E
K
V
T
G
R
---------
K
T
K
M
E
I
V
G
R
A
L
A
-
V
N
K
P
N
P
Q
D
G
L
D
V
L
A
K
V
G
G
F
E
L
G
A
L
A
G
V
I
L
G
S
A
A
N
R
C
A
V
V
I
D
G
L
N
T
T
A
A
A
L
I
A
N
V
I
H
P
L
S
K
E
Y
M
F
A
S
H
L
S
G
E
P
A
H
S
I
A
L
R
Q
L
Q
L
E
A
C
L
E
L
G
V
R
L
G
E
G
I
G
A
S
M
V
V
D
M
L
Y
V
A
I
-
K
L
L
N
N
R
G
------------
37
PsiBlast_CBE
87.16
34%
-114
- C7 -
4HDR
4
?
A:
[17-338]
-------------
D
T
V
I
K
D
Q
V
K
T
K
L
A
G
V
L
Q
S
A
G
S
L
G
R
L
E
D
M
V
E
Q
Y
A
G
I
T
G
E
L
-
N
P
A
L
P
K
P
C
M
V
V
A
S
A
D
H
G
V
A
R
R
V
V
S
A
Y
P
I
E
T
T
I
H
M
T
A
N
Y
L
I
S
Q
G
A
S
A
N
A
F
A
N
F
C
G
A
D
M
V
V
V
D
M
G
V
A
G
D
L
S
Y
V
P
G
L
W
H
R
K
I
A
Y
G
T
Q
D
F
T
E
G
P
A
M
T
--
R
E
Q
A
I
Q
A
V
E
T
G
I
D
I
V
N
D
R
V
K
H
G
N
R
C
F
C
L
G
E
M
G
I
G
N
T
T
S
S
A
T
I
V
G
A
F
T
G
L
A
P
E
K
V
T
G
R
G
T
G
----
R
L
K
T
K
M
E
I
V
G
R
A
L
A
-
V
N
K
P
N
P
Q
D
G
L
D
V
L
A
K
V
G
G
F
E
L
G
A
L
A
G
V
I
L
G
S
A
A
N
R
C
A
V
V
I
D
G
L
N
T
T
A
A
A
L
I
A
N
V
I
H
P
L
S
K
E
Y
M
F
A
S
H
L
S
G
E
P
A
H
S
I
A
L
R
Q
L
Q
L
E
A
C
L
E
L
G
V
R
L
G
E
G
I
G
A
S
M
V
V
D
M
L
Y
V
A
I
-
K
L
L
N
N
--------------
35
PsiBlast_CBE
86.94
34%
-109
- C7 -
4HDS
2
?
A:
[17-338]
-------------
D
T
V
I
K
D
Q
V
K
T
K
L
A
G
V
L
Q
S
A
G
S
L
G
R
L
E
D
M
V
E
Q
Y
A
G
I
T
G
E
L
-
N
P
A
L
P
K
P
C
M
V
V
A
S
A
D
H
G
V
A
R
R
V
V
S
A
Y
P
I
E
T
T
I
H
M
T
A
N
Y
L
I
S
Q
G
A
S
A
N
A
F
A
N
F
C
G
A
D
M
V
V
V
D
M
G
V
A
G
D
L
S
Y
V
P
G
L
W
H
R
K
I
A
Y
G
T
Q
D
F
T
E
G
P
A
M
T
--
R
E
Q
A
I
Q
A
V
E
T
G
I
D
I
V
N
D
R
V
K
H
G
N
R
C
F
C
L
G
E
M
G
I
G
N
T
T
S
S
A
T
I
V
G
A
F
T
G
L
A
P
E
K
V
T
G
R
G
-----
S
R
L
K
T
K
M
E
I
V
G
R
A
L
A
-
V
N
K
P
N
P
Q
D
G
L
D
V
L
A
K
V
G
G
F
E
L
G
A
L
A
G
V
I
L
G
S
A
A
N
R
C
A
V
V
I
D
G
L
N
T
T
A
A
A
L
I
A
N
V
I
H
P
L
S
K
E
Y
M
F
A
S
H
L
S
G
E
P
A
H
S
I
A
L
R
Q
L
Q
L
E
A
C
L
E
L
G
V
R
L
G
E
G
I
G
A
S
M
V
V
D
M
L
Y
V
A
I
-
K
L
L
N
N
--------------
39
PsiBlast_CBE
85.78
34%
-111
- C7 -
4HDK
6
?
A:
[17-338]
-------------
D
T
V
I
K
D
Q
V
K
T
K
L
A
G
V
L
Q
S
A
G
S
L
G
R
L
E
D
M
V
E
Q
Y
A
G
I
T
G
E
L
-
N
P
A
L
P
K
P
C
M
V
V
A
S
A
D
H
G
V
A
R
R
V
V
---
P
I
E
T
T
I
H
M
T
A
N
Y
L
I
S
Q
G
A
S
A
N
A
F
A
N
F
C
G
A
D
M
V
V
V
D
M
G
V
A
G
D
L
S
Y
V
P
G
L
W
H
R
K
I
A
Y
G
T
Q
D
F
T
E
G
P
A
M
T
--
R
E
Q
A
I
Q
A
V
E
T
G
I
D
I
V
N
D
R
V
K
H
G
N
R
C
F
C
L
G
E
M
G
I
G
N
T
T
S
S
A
T
I
V
G
A
F
T
G
L
A
P
E
K
V
T
G
R
G
T
G
I
S
---
L
K
T
K
M
E
I
V
G
R
A
L
A
-
V
N
K
P
N
P
Q
D
G
L
D
V
L
A
K
V
G
G
F
E
L
G
A
L
A
G
V
I
L
G
S
A
A
N
R
C
A
V
V
I
D
G
L
N
T
T
A
A
A
L
I
A
N
V
I
H
P
L
S
K
E
Y
M
F
A
S
H
L
S
G
E
P
A
H
S
I
A
L
R
Q
L
Q
L
E
A
C
L
E
L
G
V
R
L
G
E
G
I
G
A
S
M
V
V
D
M
L
Y
V
A
I
-
K
L
L
N
N
--------------