@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA1379: (2016-01-28 )
MSFRKTLLITGASSGFGQALAREALDAGHRVVGTVRSEEARSALEAVAPGQAFGRLLDVTDLAAIEPTVAAIERDIGPLDVLVNSAGYGHEGILEESPLAEMRRQFEVNLFGAVAMIQAVLPYMRRRRRGHILNITSMGGYITMPGIAYYCGSKFALEGVSEALGKEVAGLGIAVTAVAPGSFRTDWAGRSMVRSPRTIADYDALFDPVRQARQEKSGKQPGDPRKAARAMLQAIDAENPPAHLLLGSDALGLVRQKLKALEEEIAAWEEVTRSTDG
Atome Classification :
(20 SA)
.........10........20-........--30........40....------..-----..50........60........70.....-...80........90........100.......110.......120.....------..130.......140.......150.......160.......170.......180.......190.....-..200-----........210...-....220---.........230.......240..-------.....250.......260.......270.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSF
R
K
T
L
L
I
TGASS
G
F
G
Q
A
L
A
-
R
E
A
L
DAG
H
--
R
V
V
G
T
V
R
S
E
E
A
R
S
A
L
E
------AV-----A
P
G
Q
A
F
G
R
L
LDVT
D
L
AAI
E
P
T
V
A
A
I
E
RDI-G
P
L
D
V
LVNSAGYGHEGILEES
P
L
A
E
M
R
R
Q
F
E
V
N
L
F
G
A
V
A
M
I
Q
A
V
L
P
Y
M
R
R
R------RRG
H
I
L
N
I
TSMGG
Y
I
TMP
G
I
A
Y
YCG
S
K
F
A
L
E
G
V
S
E
A
L
G
K
E
VAGL
G
I
A
V
T
A
VAPGSFRTDWAGRSMVRSPR-TI
A
D
------
Y
D
A
L
F
D
P
V
R
Q
A
R
Q
E-KSGKQ-----PG
D
P
R
K
A
A
R
A
M
L
Q
A
IDAENPP
A
H
L
-------
L
LGS
D
A
L
G
L
V
R
Q
K
L
K
A
L
E
E
E
I
A
A
W
E
E
V
TRSTDG
1
PsiBlast_PDB
95.92
41%
-94
- C1 -
3M1A
1
?
A:
[6-277]
----
K
V
W
L
V
T
G
A
S
S
G
F
G
R
A
I
A
-
E
A
A
V
A
A
G
D
--
T
V
I
G
T
A
R
R
T
E
A
L
D
D
L
V
------
A
A
-----
Y
P
D
R
A
E
A
I
S
L
D
V
T
D
G
E
R
I
D
V
V
A
A
D
V
L
A
R
Y
-
G
R
V
D
V
L
V
N
N
A
G
R
T
Q
V
G
A
F
E
E
T
T
E
R
E
L
R
D
L
F
E
L
H
V
F
G
P
A
R
L
T
R
A
L
L
P
Q
M
R
E
R
------
G
S
G
S
V
V
N
I
S
S
F
G
G
Q
L
S
F
A
G
F
S
A
Y
S
A
T
K
A
A
L
E
Q
L
S
E
G
L
A
D
E
V
A
P
F
G
I
K
V
L
I
V
E
P
G
A
F
R
T
N
L
F
G
K
G
A
A
Y
F
S
E
-
E
N
P
A
------
Y
A
E
K
V
G
P
T
R
Q
L
V
Q
G
-----------
P
G
D
P
A
K
A
A
A
A
I
R
L
A
L
D
T
E
K
T
P
L
R
L
-------
A
L
G
G
D
A
V
D
F
L
T
G
H
L
D
S
V
R
A
E
L
T
E
W
E
K
V
S
R
G
T
D
F
108
HHSearch
83.48
41%
-90
- C1 -
3M1A
1
?
A:
[4-273]
--
S
A
K
V
W
L
V
T
G
A
S
S
G
F
G
R
A
I
A
-
E
A
A
V
A
A
G
D
--
T
V
I
G
T
A
R
R
T
E
A
L
D
D
L
V
------
A
A
-----
Y
P
D
R
A
E
A
I
S
L
D
V
T
D
G
E
R
I
D
V
V
A
A
D
V
L
A
R
Y
-
G
R
V
D
V
L
V
N
N
A
G
R
T
Q
V
G
A
F
E
E
T
T
E
R
E
L
R
D
L
F
E
L
H
V
F
G
P
A
R
L
T
R
A
L
L
P
Q
M
R
E
R
------
G
S
G
S
V
V
N
I
S
S
F
G
G
Q
L
S
F
A
G
F
S
A
Y
S
A
T
K
A
A
L
E
Q
L
S
E
G
L
A
D
E
V
A
P
F
G
I
K
V
L
I
V
E
P
G
A
F
R
T
N
L
F
G
K
G
-
A
A
Y
F
S
E
E
N
P
A
------
Y
A
E
K
V
G
P
T
R
Q
L
V
Q
G
-----------
P
G
D
P
A
K
A
A
A
A
I
R
L
A
L
D
T
E
K
T
P
L
R
L
A
L
G
G
D
A
V
D
F
L
T
G
H
L
D
S
V
R
A
E
L
T
E
W
E
K
V
S
R
G
T
D
F
-------
53
PsiBlast_CBE
74.29
32%
-90
- C1 -
3HB4
1
DHB1_HUMAN
X:
[2-267]
---
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
SF
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
EAARAL
A
C
-----
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
---
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
------
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
-
V
L
G
S
P
E
-
E
V
L
D
------
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
-
A
H
S
K
Q
VFREA
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
--
74
PsiBlast_CBE
74.17
32%
-88
- C1 -
1FDU
3
DHB1_HUMAN
C:
[2-267]
---
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
SF
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
-----
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
---
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
------
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
-
V
L
G
S
P
E
-
E
V
L
D
------
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
-
A
L
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
G
-
60
PsiBlast_CBE
73.10
32%
-83
- C1 -
1I5R
4
DHB1_HUMAN
A:
[2-267]
---
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
SF
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
-----
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
---
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
------
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
-
V
L
G
S
P
E
-
E
V
L
D
------
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
-
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
G
-
20
PsiBlast_PDB
72.94
32%
-95
- C1 -
1FDW
1
DHB1_HUMAN
A:
[2-267]
---
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
SF
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
-----
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
---
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
------
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
-------
G
S
P
E
-
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
Q
S
K
Q
V
F
R
E
A
A
Q
-------
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
G
-
19
PsiBlast_PDB
72.07
32%
-87
- C1 -
1IOL
1
DHB1_HUMAN
A:
[2-267]
---
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
-----
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
---
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
E
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
------
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
-
V
L
G
S
P
E
-
E
V
L
D
------
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
-
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
--
63
PsiBlast_CBE
72.04
32%
-89
- C1 -
1DHT
1
DHB1_HUMAN
A:
[2-267]
---
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
-----
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
---
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
------
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
-
V
L
G
S
P
E
-
E
V
L
D
------
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
-
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
--
52
PsiBlast_CBE
71.98
32%
-88
- C1 -
3HB5
2
DHB1_HUMAN
X:
[2-267]
---
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
SF
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
EAARAL
A
C
-----
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
---
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
------
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
-
V
L
G
S
P
E
-
E
V
L
D
------
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
-
A
H
S
K
Q
VFREA
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
--
62
PsiBlast_CBE
71.54
32%
-86
- C1 -
1EQU
2
DHB1_HUMAN
A:
[2-267]
---
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
SF
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
-----
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
---
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
------
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
-
V
L
G
S
P
E
-
E
V
L
D
------
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
-
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
--
54
PsiBlast_CBE
70.94
32%
-86
- C1 -
3DHE
1
DHB1_HUMAN
A:
[2-267]
---
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
-----
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
---
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
------
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
-
V
L
G
S
P
E
-
E
V
L
D
------
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
-
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
--
72
PsiBlast_CBE
70.65
32%
-93
- C1 -
1FDV
3
DHB1_HUMAN
A:
[2-267]
---
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
SF
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
-----
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
---
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
------
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
-
V
L
G
S
P
E
-
E
V
L
D
------
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
-
A
L
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
G
-
48
PsiBlast_CBE
70.63
32%
-86
- C1 -
1A27
2
DHB1_HUMAN
A:
[2-267]
---
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
SF
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
-----
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
---
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
------
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
-
V
L
G
S
P
E
-
E
V
L
D
------
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
-
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
G
-
65
PsiBlast_CBE
70.53
32%
-89
- C1 -
1FDT
3
DHB1_HUMAN
A:
[2-267]
---
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
-----
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
---
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
------
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
-
V
L
G
S
P
E
-
E
V
L
D
------
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
-
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
G
-
66
PsiBlast_CBE
70.48
32%
-88
- C1 -
1FDS
1
DHB1_HUMAN
A:
[2-267]
---
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
SF
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
-----
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
---
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
------
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
------
V
L
G
S
P
E
-
E
V
L
D
------
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
-
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
G
D
58
PsiBlast_CBE
70.37
32%
-89
- C1 -
1QYV
2
DHB1_HUMAN
A:
[2-267]
---
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
SF
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
-----
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
---
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
------
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
---------
S
P
E
-
E
V
L
D
------
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
-
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
--
61
PsiBlast_CBE
69.74
32%
-90
- C1 -
1EQU
1
DHB1_HUMAN
B:
[2-267]
---
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
SF
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
EAARAL
A
C
-----
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
---
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
------
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
-
V
L
G
S
P
E
-
E
V
L
D
------
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
-
A
H
S
K
Q
VFREA
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
--
70
PsiBlast_CBE
69.24
32%
-83
- C1 -
1FDV
3
DHB1_HUMAN
C:
[2-267]
---
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
SF
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
EAARAL
A
C
-----
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
---
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
------
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
-
V
L
G
S
P
E
-
E
V
L
D
------
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
-
A
L
S
K
Q
VFREA
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
G
-
118
HHSearch
69.02
23%
-92
- C1 -
3IOY
-
?
A:
[4-279]
-
F
A
G
R
T
A
F
V
T
G
G
A
N
G
V
G
I
G
L
V
-
R
Q
L
L
N
Q
G
C
--
K
V
A
I
A
D
I
R
Q
D
S
I
D
K
A
L
------
A
T
L
E
A
E
G
S
G
P
E
V
M
G
V
Q
L
D
V
A
S
R
E
G
F
K
M
A
A
D
E
V
E
A
R
F
-
G
P
V
S
I
L
C
N
N
A
G
V
N
L
F
Q
P
I
E
E
S
S
Y
D
D
W
D
W
L
L
G
V
N
L
H
G
V
V
N
G
V
T
T
F
V
P
R
M
V
E
R
V
K
A
GEQ
K
G
G
H
V
V
N
T
A
S
M
A
A
F
L
A
A
G
S
P
G
I
Y
N
T
T
K
F
A
V
R
G
L
S
E
S
L
H
Y
S
L
L
K
Y
E
I
G
V
S
V
L
C
P
G
L
V
K
-------------------------------------
A
-
G
V
H
E
F
-----
G
M
E
P
D
V
I
G
A
R
V
I
E
A
M
K
A
N
--
R
L
H
I
-------
F
S
H
P
D
H
K
E
E
L
R
E
V
F
D
E
I
I
A
E
Y
Q
D
Y
P
K
D
P
G
Y
D
Q
R
59
PsiBlast_CBE
68.79
32%
-89
- C1 -
1JTV
2
DHB1_HUMAN
A:
[2-267]
---
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
SF
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
-----
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
---
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
------
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
--------
G
S
P
E
-
E
V
L
D
------
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
-
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
-------
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
G
-