@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA1384: (2016-01-28 )
MRVLVTGGAGFIGSHVLVELLGQGAKVVVLDNLVNGSSESLKRVERITGHPVGFVLGDVRDSLLVERLLIDEKVDAVIHLAGLKAVGESVDDPLEYYESNVQGTISLLRAMQRVGVFKIVFSSSATIYQMPGTLPISESSKVGGVASPYGRTKLTAEHMLDDLARSDTRWSIAVLRYFNPIGAHESGLIGEDPCGTPNNLLPYIAQVAVGRLSRLTVHGGDYPTIDGTGVRDYIHVCDLAAGHTRALEYLGQGHGYHVWNLGTGTGYSVLQVIEAFERVSGRRIPFTVSGRRPGDVAECWADVSKAERELGWKAGLGLECMIADAWRWQVSNPSGYS
Atome Classification :
(41 SA)
-.........10........20........30....-----..------..40........50........60........-70........80........90........100.......110.......120......----.130.......140.......150.......160.....-------------..-170.......180.......190.......200.......210.......220.......230.......240.......250-....----..-...260.......270.......280.......290.......300.......310.......320.......330.....-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-
M
R
V
L
V
TGG
A
G
F
I
G
S
H
V
L
V
E
L
L
GQG
A
K
V
V
V
L
DNLVN-----G
S
------
S
E
S
L
K
R
V
E
R
ITGHP
V
G
F
V
L
G
D
V
R
D
S
L
L
V
E
R
L
L
-
I
D
E
K
V
D
A
V
I
H
L
A
G
L
K
A
V
GESVD
D
P
L
E
Y
Y
E
SN
V
Q
G
T
I
S
L
L
R
A
M
Q
RV
G
V
F
K
I
V
FSSS
A
T
I
Y
----QMPGTLPISESSKVGGVASPYGRTKL
T
A
E
H
M
L
D
D
L
ARSD-------------T
R
-
W
S
I
A
V
L
R
YFNPIGAHESGLIGEDPCGTP
N
N
L
L
P
Y
I
A
Q
V
A
VGR
L
S
R
L
T
VHGGDYPTIDGT
G
V
R
D
Y
I
H
V
CDLAA
G
H
T
R
A
L
E
Y
L
---GQGH----
G
Y
-
H
V
W
NLGTG
T
G
Y
S
V
L
Q
V
I
E
A
F
E
R
VSGRRI
P
F
T
VSGRRPG
D
V
A
E
C
W
A
D
V
S
K
A
E
R
E
LGWKAGLG
L
E
C
M
I
AD
A
W
R
W
QVSNPSGYS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
98.40
55%
-111
- C1 -
1EK5
1
GALE_HUMAN
A:
[4-344]
--
K
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
N
A
F
R
G
G
G
S
L-----
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
-
K
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
----
G
N
P
Q
Y
L
P
L
D
E
A
H
P
T
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
A
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
---
K
E
Q
C
----
G
C
-
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
97.88
55%
-111
- C1 -
1EK6
4
GALE_HUMAN
A:
[4-344]
--
K
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
N
A
F
R
G
G
G
S
L-----
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
-
K
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
----
G
N
P
Q
Y
L
P
L
D
E
A
H
P
T
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
A
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
---
K
E
Q
C
----
G
C
-
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
97.52
54%
-111
- C1 -
1I3L
6
GALE_HUMAN
B:
[4-344]
--
K
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
N
AFRGG
G
S
L-----
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
-
K
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
----
G
N
P
Q
Y
L
P
L
D
E
A
H
P
T
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
V
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
---
K
E
Q
C
----
G
C
-
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
96.59
54%
-109
- C1 -
1I3M
4
GALE_HUMAN
A:
[4-344]
--
K
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
N
A
F
R
G
G
G
S
L-----
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
-
K
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
----
G
N
P
Q
Y
L
P
L
D
E
A
H
P
T
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
V
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
---
K
E
Q
C
----
G
C
-
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
HHSearch
96.32
56%
-109
- C1 -
1EK6
4
GALE_HUMAN
A:
[3-343]
-
E
K
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
N
-----
A
F
R
G
GGSL
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
-
K
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
----
G
N
P
Q
Y
L
P
L
D
E
A
H
P
T
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
A
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
---
K
E
Q
C
----
G
C
-
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
96.10
53%
-112
- C1 -
1LRK
5
GALE_ECOLI
A:
[1-336]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
-----
S
K
------
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
----
G
D
N
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
---
A
N
K
P
----
G
V
-
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
C
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
96.04
54%
-110
- C1 -
1I3K
5
GALE_HUMAN
A:
[4-344]
--
K
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
N
A
F
R
G
G
G
S
L-----
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
-
K
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
----
G
N
P
Q
Y
L
P
L
D
E
A
H
P
T
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
V
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
---
K
E
Q
C
----
G
C
-
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
95.83
54%
-110
- C1 -
1I3L
5
GALE_HUMAN
A:
[4-344]
--
K
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
N
A
F
R
G
G
G
S
L-----
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
-
K
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
----
G
N
P
Q
Y
L
P
L
D
E
A
H
P
T
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
V
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
---
K
E
Q
C
----
G
C
-
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
95.68
54%
-108
- C1 -
1I3N
4
GALE_HUMAN
B:
[4-344]
--
K
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
N
AFRGG
G
S
L-----
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
-
K
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
----
G
N
P
Q
Y
L
P
L
D
E
A
H
P
T
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
V
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
---
K
E
Q
C
----
G
C
-
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
95.67
54%
-109
- C1 -
1I3N
6
GALE_HUMAN
A:
[4-344]
--
K
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
N
A
F
R
G
G
G
S
L-----
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
-
K
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
----
G
N
P
Q
Y
L
P
L
D
E
A
H
P
T
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
V
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
---
K
E
Q
C
----
G
C
-
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
94.88
54%
-110
- C1 -
1I3K
7
GALE_HUMAN
B:
[4-344]
--
K
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
N
AFRGG
G
S
L-----
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
-
K
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
----
G
N
P
Q
Y
L
P
L
D
E
A
H
P
T
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
V
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
---
K
E
Q
C
----
G
C
-
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
94.47
55%
-109
- C1 -
1EK6
3
GALE_HUMAN
B:
[4-344]
--
K
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
N
A
F
R
G
G
G
S
L-----
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
-
K
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
----
G
N
P
Q
Y
L
P
L
D
E
A
H
P
T
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
A
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
---
K
E
Q
C
----
G
C
-
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
94.24
55%
-107
- C1 -
1HZJ
4
GALE_HUMAN
A:
[4-344]
--
K
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
N
AFRGG
G
S
L-----
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
-
K
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
----
G
N
P
Q
Y
L
P
L
D
E
A
H
P
T
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
V
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
---
K
E
Q
C
----
G
C
-
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
HHSearch
94.09
56%
-111
- C1 -
3ENK
2
?
A:
[6-340]
-
G
T
I
L
V
T
G
G
A
G
Y
I
G
S
H
T
A
V
E
L
L
A
H
G
Y
D
V
V
I
A
D
N
L
V
N
-----
S
K
------
R
E
A
I
A
R
I
E
K
I
T
G
K
T
P
A
F
H
E
T
D
V
S
D
E
R
A
L
A
R
I
F
-
D
A
H
P
I
T
A
A
I
H
F
A
A
L
K
A
V
G
E
S
V
A
K
P
I
E
Y
Y
R
N
N
L
D
S
L
L
S
L
L
R
V
M
R
E
R
A
V
K
R
I
V
F
S
S
S
A
T
V
Y
----
G
V
P
E
R
S
P
I
D
E
T
F
P
L
S
-
A
T
N
P
Y
G
Q
T
K
L
M
A
E
Q
I
L
R
D
V
E
A
A
D
-------------
P
S
-
W
R
V
A
T
L
R
Y
F
N
P
V
G
A
H
E
S
G
L
I
G
E
D
P
A
G
I
P
N
N
L
M
P
Y
V
A
Q
V
A
V
G
K
L
E
K
L
R
V
F
G
S
D
Y
P
T
P
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
R
G
H
I
A
A
L
D
A
L
---
E
R
R
D
----
A
S
-
L
T
V
N
L
G
T
G
R
G
Y
S
V
L
E
V
V
R
A
F
E
K
A
S
G
R
A
V
P
Y
E
L
V
A
R
R
P
G
D
V
A
E
C
Y
A
N
P
A
A
A
A
E
T
I
G
W
K
A
E
R
D
L
E
R
M
C
A
D
H
W
R
W
Q
E
N
N
P
R
G
F
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
93.98
53%
-109
- C1 -
1LRL
5
GALE_ECOLI
A:
[1-336]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
-----
S
K
------
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
----
G
D
N
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
---
A
N
K
P
----
G
V
-
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
C
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
93.57
53%
-106
- C1 -
1UDC
9
GALE_ECOLI
A:
[1-336]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
-----
S
K
------
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
----
G
D
Q
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
---
A
N
K
P
----
G
V
-
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
93.36
54%
-107
- C1 -
1I3M
5
GALE_HUMAN
B:
[4-344]
--
K
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
N
AFRGG
G
S
L-----
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
-
K
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
----
G
N
P
Q
Y
L
P
L
D
E
A
H
P
T
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
V
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
---
K
E
Q
C
----
G
C
-
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
93.30
52%
-110
- C1 -
1KVS
5
GALE_ECOLI
A:
[1-336]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
-----
S
K
------
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
T
A
T
V
Y
----
G
D
N
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
---
A
N
K
P
----
G
V
-
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
93.17
55%
-107
- C1 -
1HZJ
3
GALE_HUMAN
B:
[4-344]
--
K
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
N
AFRGG
G
S
L-----
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
-
K
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
----
G
N
P
Q
Y
L
P
L
D
E
A
H
P
T
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
V
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
---
K
E
Q
C
----
G
C
-
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
93.15
53%
-107
- C1 -
1XEL
6
GALE_ECOLI
A:
[1-336]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
-----
S
K
------
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
----
G
D
N
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
---
A
N
K
P
----
G
V
-
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
92.45
53%
-108
- C1 -
1LRJ
5
GALE_ECOLI
A:
[1-336]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
-----
S
K
------
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
----
G
D
N
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
---
A
N
K
P
----
G
V
-
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
92.36
52%
-107
- C1 -
1KVQ
5
GALE_ECOLI
A:
[1-336]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
-----
S
K
------
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
A
A
T
V
Y
----
G
D
N
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
---
A
N
K
P
----
G
V
-
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
92.18
55%
-111
- C1 -
3ENK
2
?
A:
[8-340]
---
I
L
V
T
G
G
A
G
Y
I
G
S
H
T
A
V
E
L
L
A
H
G
Y
D
V
V
I
A
D
N
L
V
N
-----
S
K
------
R
E
A
I
A
R
I
E
K
I
T
G
K
T
P
A
F
H
E
T
D
V
S
D
E
R
A
L
A
R
I
F
-
D
A
H
P
I
T
A
A
I
H
F
A
A
L
K
A
V
G
E
S
V
A
K
P
I
E
Y
Y
R
N
N
L
D
S
L
L
S
L
L
R
V
M
R
E
R
A
V
K
R
I
V
F
S
S
S
A
T
V
Y
----
G
V
P
E
R
S
P
I
D
E
T
F
P
L
S
A
T
-
N
P
Y
G
Q
T
K
L
M
A
E
Q
I
L
R
D
V
E
A
A
D
-------------
P
S
-
W
R
V
A
T
L
R
Y
F
N
P
V
G
A
H
E
S
G
L
I
G
E
D
P
A
G
I
P
N
N
L
M
P
Y
V
A
Q
V
A
V
G
K
L
E
K
L
R
V
F
G
S
D
Y
P
T
P
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
R
G
H
I
A
A
L
D
A
L
---
E
R
R
D
----
A
S
-
L
T
V
N
L
G
T
G
R
G
Y
S
V
L
E
V
V
R
A
F
E
K
A
S
G
R
A
V
P
Y
E
L
V
A
R
R
P
G
D
V
A
E
C
Y
A
N
P
A
A
A
A
E
T
I
G
W
K
A
E
R
D
L
E
R
M
C
A
D
H
W
R
W
Q
E
N
N
P
R
G
F
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
91.76
52%
-108
- C1 -
1A9Y
5
GALE_ECOLI
A:
[1-336]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
-----
S
K
------
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
A
A
T
V
Y
----
G
D
Q
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
F
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
---
A
N
K
P
----
G
V
-
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
91.61
53%
-106
- C1 -
1NAH
5
GALE_ECOLI
A:
[1-336]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
-----
S
K
------
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
----
G
D
N
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
---
A
N
K
P
----
G
V
-
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
91.58
52%
-107
- C1 -
1A9Z
6
GALE_ECOLI
A:
[1-336]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
-----
S
K
------
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
A
A
T
V
Y
----
G
D
N
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
F
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
---
A
N
K
P
----
G
V
-
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
91.52
53%
-104
- C1 -
1UDB
7
GALE_ECOLI
A:
[1-336]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
-----
S
K
------
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
----
G
D
N
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
---
A
N
K
P
----
G
V
-
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
91.49
52%
-105
- C1 -
1KVU
7
GALE_ECOLI
A:
[1-336]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
-----
S
K
------
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
----
G
D
Q
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
F
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
---
A
N
K
P
----
G
V
-
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
91.41
52%
-106
- C1 -
1KVT
4
GALE_ECOLI
A:
[1-336]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
-----
S
K
------
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
V
A
T
V
Y
----
G
D
N
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
---
A
N
K
P
----
G
V
-
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
HHSearch
91.32
53%
-103
- C1 -
1UDB
7
GALE_ECOLI
A:
[1-337]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
-----
S
K
------
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
----
G
D
N
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
---
A
N
K
P
----
G
V
-
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
91.07
53%
-108
- C1 -
1NAI
5
GALE_ECOLI
A:
[1-336]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
-----
S
K
------
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
----
G
D
N
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
---
A
N
K
P
----
G
V
-
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
91.01
53%
-104
- C1 -
1UDA
7
GALE_ECOLI
A:
[1-336]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
-----
S
K
------
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
----
G
D
N
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
---
A
N
K
P
----
G
V
-
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
90.95
53%
-105
- C1 -
2UDP
2
GALE_ECOLI
B:
[1-336]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
-----
S
K
------
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
----
G
D
Q
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
---
A
N
K
P
----
G
V
-
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
90.90
55%
-111
- C1 -
3ENK
2
?
B:
[8-340]
---
I
L
V
T
G
G
A
G
Y
I
G
S
H
T
A
V
E
L
L
A
H
G
Y
D
V
V
I
A
D
N
L
V
N
-----
S
K
------
R
E
A
I
A
R
I
E
K
I
T
G
K
T
P
A
F
H
E
T
D
V
S
D
E
R
A
L
A
R
I
F
-
D
A
H
P
I
T
A
A
I
H
F
A
A
L
K
A
V
G
E
S
V
A
K
P
I
E
Y
Y
R
N
N
L
D
S
L
L
S
L
L
R
V
M
R
E
R
A
V
K
R
I
V
F
S
S
S
A
T
V
Y
----
G
V
P
E
R
S
P
I
D
E
T
F
P
L
S
A
T
-
N
P
Y
G
Q
T
K
L
M
A
E
Q
I
L
R
D
V
E
A
A
D
-------------
P
S
-
W
R
V
A
T
L
R
Y
F
N
P
V
G
A
H
E
S
G
L
I
G
E
D
P
A
G
I
P
N
N
L
M
P
Y
V
A
Q
V
A
V
G
K
L
E
K
L
R
V
F
G
S
D
Y
P
T
P
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
R
G
H
I
A
A
L
D
A
L
---
E
R
R
D
----
A
S
-
L
T
V
N
L
G
T
G
R
G
Y
S
V
L
E
V
V
R
A
F
E
K
A
S
G
R
A
V
P
Y
E
L
V
A
R
R
P
G
D
V
A
E
C
Y
A
N
P
A
A
A
A
E
T
I
G
W
K
A
E
R
D
L
E
R
M
C
A
D
H
W
R
W
Q
E
N
N
P
R
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
90.55
53%
-106
- C1 -
2UDP
4
GALE_ECOLI
A:
[1-336]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
-----
S
K
------
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
----
G
D
Q
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
---
A
N
K
P
----
G
V
-
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
89.89
52%
-104
- C1 -
1KVR
8
GALE_ECOLI
A:
[1-336]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
-----
S
K
------
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
A
A
T
V
Y
----
G
D
Q
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
---
A
N
K
P
----
G
V
-
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
Fugue
87.56
51%
-108
- C1 -
1Z45
5
GAL10_YEAST
A:
[11-699]
S
K
I
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
V
E
L
I
E
N
G
Y
D
C
V
V
A
D
N
L
S
N
-----
S
T
------
Y
D
S
V
A
R
L
E
V
L
T
K
H
H
I
P
F
Y
E
V
D
L
C
D
R
K
G
L
E
K
V
F
-
K
E
Y
K
I
D
S
V
I
H
F
A
G
L
K
A
V
G
E
S
T
Q
I
P
L
R
Y
Y
H
N
N
I
L
G
T
V
V
L
L
E
L
M
Q
Q
Y
N
V
S
K
F
V
F
S
S
S
A
T
V
Y
GDAT
R
F
P
N
M
I
P
I
P
E
E
C
P
L
G
-
P
T
N
P
Y
G
H
T
K
Y
A
I
E
N
I
L
N
D
L
Y
N
S
D
-------------
K
K
S
W
K
F
A
I
L
R
Y
F
N
P
I
G
A
H
P
S
G
L
I
G
E
D
P
L
G
I
P
N
N
L
L
P
Y
M
A
Q
V
A
V
G
R
R
E
K
L
Y
I
F
R
------
D
G
T
P
I
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
Q
Y
L
---
E
A
Y
N
EN
E
G
L
C
-
R
E
W
N
L
G
S
G
K
G
S
T
V
F
E
V
Y
H
A
F
C
K
A
S
G
I
D
L
P
Y
V
L
N
---------
L
T
A
K
P
D
R
A
K
R
E
L
K
W
Q
T
E
L
Q
V
E
D
S
C
K
D
L
W
K
W
T
T
E
N
P
F
G
Y
Q
LRG
V
E
A
R
F
SAEDMRYDA
R
F
V
T
I
GAGTR
F
Q
A
T
F
A
NLGASIV
D
L
K
V
NGQSV
V
L
G
Y
EN
E
E
G
Y
L
NPDSAYIGATIGRYANRISKG
K
F
S
L
CN
K
D
Y
Q
L
TVNNGVNANHSSIGSFHR
K
R
F
L
G
P
I
I
Q
NPSKD
V
F
T
A
E
Y
M
L
I
D
N
EKDTEFP
G
D
L
L
V
T
I
Q
Y
T
V
N
VAQK
S
L
E
I
V
Y
K
G
K
L
TAGE
A
T
P
I
N
L
T
N
H
S
Y
F
N
LNKPYGDTIEG
T
E
I
M
V
RSK
K
S
V
D
V
D
KNMIPTG
N
I
V
D
R
EIATFNSTK
P
T
V
L
G
PKNP
Q
F
D
C
C
F
V
VDENAKPSQINTLNNELTLI
V
K
A
F
H
PDSN
I
T
L
E
V
L
S
TEP
T
Y
Q
F
Y
TGDFLSAGYEARQ
G
F
A
I
E
P
G
RYIDAINQENWKDCVTLKNG
E
T
Y
G
S
K
I
V
Y
R
F
S
35
PsiBlast_CBE
85.26
47%
-107
* C1 *
4LIS
6
?
C:
[6-357]
---
V
L
V
T
G
G
T
G
Y
I
G
S
F
T
T
L
A
L
L
E
A
G
Y
K
V
V
V
A
D
N
L
Y
N
-----
S
S
------
A
E
A
L
N
R
I
E
L
I
S
G
K
K
A
E
F
A
Q
L
D
V
T
D
E
A
A
F
D
K
V
F
E
A
H
P
D
I
D
S
V
I
H
F
A
A
L
K
A
V
G
E
S
G
E
K
P
L
D
Y
Y
H
V
N
V
Y
G
T
I
C
L
L
R
S
M
V
R
H
N
V
T
N
I
V
F
S
S
S
A
T
V
Y
GDAT
R
F
P
D
M
I
P
I
P
E
H
C
P
L
G
P
T
-
N
P
Y
G
N
T
K
F
A
I
E
L
A
I
T
D
V
I
N
A
Q
RNNAKKAGNETEA
A
K
-
W
N
G
A
L
L
R
Y
F
N
P
A
G
A
H
P
S
G
I
M
G
E
D
P
Q
G
V
P
Y
N
L
L
P
L
L
A
Q
V
A
T
G
K
R
E
K
L
L
V
F
G
D
D
Y
A
S
H
D
G
T
A
I
R
D
Y
I
H
I
L
D
L
A
D
G
H
L
K
A
L
N
Y
L
R--
A
N
N
P
----
G
V
-
R
A
W
N
L
G
T
G
R
G
S
T
V
Y
E
M
I
R
A
F
S
K
A
V
G
R
D
L
P
Y
E
V
A
P
R
R
A
G
D
V
L
N
L
T
S
N
P
T
R
A
N
T
E
L
G
W
K
A
Q
R
T
L
E
Q
A
C
E
D
L
W
L
W
T
K
N
N
P
Q
G
Y
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
84.88
47%
-108
- C1 -
4LIS
6
?
A:
[6-357]
---
V
L
V
T
G
G
T
G
Y
I
G
S
F
T
T
L
A
L
L
E
A
G
Y
K
V
V
V
A
D
N
L
Y
N
-----
S
S
------
A
E
A
L
N
R
I
E
L
I
S
G
K
K
A
E
F
A
Q
L
D
V
T
D
E
A
A
F
D
K
V
F
E
A
H
P
D
I
D
S
V
I
H
F
A
A
L
K
A
V
G
E
S
G
E
K
P
L
D
Y
Y
H
V
N
V
Y
G
T
I
C
L
L
R
S
M
V
R
H
N
V
T
N
I
V
F
S
S
S
A
T
V
Y
GDAT
R
F
P
D
M
I
P
I
P
E
H
C
P
L
G
P
T
-
N
P
Y
G
N
T
K
F
A
I
E
L
A
I
T
D
V
I
N
A
Q
R
N
N
A
K
K
A
GN
E
T
E
A
A
K
-
W
N
G
A
L
L
R
Y
F
N
P
A
G
A
H
P
S
G
I
M
G
E
D
P
Q
G
V
P
Y
N
L
L
P
L
L
A
Q
V
A
T
G
K
R
E
K
L
L
V
F
G
D
D
Y
A
S
H
D
G
T
A
I
R
D
Y
I
H
I
L
D
L
A
D
G
H
L
K
A
L
N
Y
L
R
--
A
N
N
P
----
G
V
-
R
A
W
N
L
G
T
G
R
G
S
T
V
Y
E
M
I
R
A
F
S
K
A
V
G
R
D
L
P
Y
E
V
A
P
R
R
A
G
D
V
L
N
L
T
S
N
P
T
R
A
N
T
E
L
G
W
K
A
Q
R
T
L
E
Q
A
C
E
D
L
W
L
W
T
K
N
N
P
Q
G
Y
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
84.87
50%
-111
- C1 -
1Z45
3
GAL10_YEAST
A:
[14-356]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
V
E
L
I
E
N
G
Y
D
C
V
V
A
D
N
L
S
N
-----
S
T
------
Y
D
S
V
A
R
L
E
V
L
T
K
H
H
I
P
F
Y
E
V
D
L
C
D
R
K
G
L
E
K
V
F
-
K
E
Y
K
I
D
S
V
I
H
F
A
G
L
K
A
V
G
E
S
T
Q
I
P
L
R
Y
Y
H
N
N
I
L
G
T
V
V
L
L
E
L
M
Q
Q
Y
N
V
S
K
F
V
F
S
S
S
A
T
V
Y
GDAT
R
F
P
N
M
I
P
I
P
E
E
C
P
L
G
P
T
-
N
P
Y
G
H
T
K
Y
A
I
E
N
I
L
N
D
L
Y
N
S
D
-------------
K
K
S
W
K
F
A
I
L
R
Y
F
N
P
I
G
A
H
P
S
G
L
I
G
E
D
P
L
G
I
P
N
N
L
L
P
Y
M
A
Q
V
A
V
G
R
R
E
K
L
Y
I
F
------
R
D
G
T
P
I
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
Q
Y
L
E
A
Y
N
E
N
E
----
G
L
C
R
E
W
N
L
G
S
G
K
G
S
T
V
F
E
V
Y
H
A
F
C
K
A
S
G
I
D
L
P
Y
---------
V
L
N
L
T
A
K
P
D
R
A
K
R
E
L
K
W
Q
T
E
L
Q
V
E
D
S
C
K
D
L
W
K
W
T
T
E
N
P
F
G
Y
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
83.60
47%
-108
- C1 -
4LIS
6
?
B:
[6-357]
---
V
L
V
T
G
G
T
G
Y
I
G
S
F
T
T
L
A
L
L
E
A
G
Y
K
V
V
V
A
D
N
L
Y
N
-----
S
S
------
A
E
A
L
N
R
I
E
L
I
S
G
K
K
A
E
F
A
Q
L
D
V
T
D
E
A
A
F
D
K
V
F
E
A
H
P
D
I
D
S
V
I
H
F
A
A
L
K
A
V
G
E
S
G
E
K
P
L
D
Y
Y
H
V
N
V
Y
G
T
I
C
L
L
R
S
M
V
R
H
N
V
T
N
I
V
F
S
S
S
A
T
V
Y
GDAT
R
F
P
D
M
I
P
I
P
E
H
C
P
L
G
P
T
-
N
P
Y
G
N
T
K
F
A
I
E
L
A
I
T
D
V
I
N
A
Q
R
N
N
A
K
K
A
GN
E
T
E
A
A
K
-
W
N
G
A
L
L
R
Y
F
N
P
A
G
A
H
P
S
G
I
M
G
E
D
P
Q
G
V
P
Y
N
L
L
P
L
L
A
Q
V
A
T
G
K
R
E
K
L
L
V
F
G
D
D
Y
A
S
H
D
G
T
A
I
R
D
Y
I
H
I
L
D
L
A
D
G
H
L
K
A
L
N
Y
L
R
--
A
N
N
P
----
G
V
-
R
A
W
N
L
G
T
G
R
G
S
T
V
Y
E
M
I
R
A
F
S
K
A
V
G
R
D
L
P
Y
E
V
A
P
R
R
A
G
D
V
L
N
L
T
S
N
P
T
R
A
N
T
E
L
G
W
K
A
Q
R
T
L
E
Q
A
C
E
D
L
W
L
W
T
K
N
N
P
Q
G
Y
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------