@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA1386: (2016-01-28 )
MKGNAPVLAAVDISKGFRVYRAPHQRMLQAIWGERKKFYSEFWALRNVSFQVFPGEVVGVIGCNGSGKSTLLQILAGTLRPTSGQVVRPERVAALLELGAGFNMEYTGRENIIFNAMLLGLGEQEISERLDEIIQFADIGEFIDRPVRTYSSGMFVRLAFSIAAYVDADVLIVDEALAVGDAAFQFKCLNRLEELLLKGITILLVSHDIQLIKSYCSRAIYLSKGRVIFDGDCETATELYLRDSIETQRAEVRSGSLIASGEHGNSVIAYGNGQGRFLSIRMGVLDEARDYFDSGERVWVEVLVQFDLPVPEHPKITLTIRDQRGYNLYGINNLLLGKALNVEPDGRLRTRISFDCDLQAGEYALTFRLENSLSESVCELMDKKVNAAIFRVFNSPKCFDAVVNLHGAFEPVPFCCETRATQ
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80.....------.----------..90.-----.----------------.-------------..------...100---...------.-----.....110......----------.120----------------.-----........130.....--..140........150.......160.......170.......180.......190...--..-.-.200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKGNA
P
V
L
A
A
V
DISKG
F
R
V
YRA
P
H
Q
R
M
L
Q
A
I
W
G
E
R
K
K
F
Y
S
E
F
W
A
L
RNV
S
F
Q
VFPG
E
V
V
G
V
I
GCNGS
G
K
S
T
L
L
Q
I
L
A
G
TLRPTSGQV------V----------
R
P
E
R
V
-----
A
----------------
A
-------------
L
L
------
E
LGA-----GFN------
M
-----
E
YTGRE
N
I
I
F
N
A
M
L
----------LG------------------L-----
G
E
Q
E
I
S
E
R
L
D
E
I
I
Q
F
A
--
D
I
G
-
E
F
I
D
R
P
V
R
T
YSS
G
M
F
V
R
L
A
F
S
I
A
A
YVD
A
D
V
L
I
V
DEALAVG
D
A
A
F
Q
F
K
C
L
N
R
L
E
E
L
--
L
L-K-G
I
T
I
L
L
VSH
D
I
Q
L
I
K
S
Y
C
SR
A
I
Y
LSKG
R
V
I
F
DGDC
E
T
A
T
E
L
Y
L
RDSI
E
T
Q
R
A
EVRSG
S
L
I
A
SGEHG
N
S
V
I
A
YGNGQ
G
R
F
L
S
I
RM
G
V
L
D
E
A
R
D
Y
F
DSG
E
R
V
W
V
E
V
L
V
Q
FDLPVPEH
P
K
I
T
L
T
I
RDQRG
Y
N
L
YGINN
L
L
LGKALNVEPDG
R
L
R
T
R
I
S
F
D
CDLQAG
E
Y
A
L
T
F
R
L
E
N
S
L
S
E
S
V
C
E
L
M
D
KK
V
N
A
A
I
F
R
VFNSP
K
C
F
D
A
V
V
N
LHGAFEPVPFCCETRATQ
6
PsiBlast_PDB
82.48
25%
-151
- C2 -
1G6H
3
LIVG_METJA
A:
[15-247]
------------------------------------
K
Y
F
G
E
F
K
A
L
D
G
V
S
I
S
V
N
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
G
R
V
Y
F
ENKD
I
----------
T
N
K
E
P
-----
A
----------------
E
-------------
L
Y
------
H
Y
G
I
V
R
---
T
F
Q
------
T
-----
P
Q
P
L
K
E
M
T
V
L
E
N
L
L
----------
I
G
E
I
C
PGES
P
L
N
S
L
F
Y
KKWI
P
-----
K
E
E
E
M
V
E
K
A
F
K
I
L
E
F
L
--
K
L
S
-
H
L
Y
D
R
K
A
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
N
P
K
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
H
V
L
E
L
--
K
A
-
K
-
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
F
N
G
Q
I
I
A
E
G
R
G
E
E
E
I
K
N
V
L
S
D
P
K
V
V
E
I
Y
I
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
82.25
31%
-129
- C2 -
1VPL
2
?
A:
[31-249]
--------------------------------------------
L
K
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
K
P
S
S
G
I
V
------
T
V
FGKNVVE--
E
P
H
E
V
-----
R
----------------
K
-------------
L
I
S
Y
L
P
E
-
E
A
G
A
-----
Y
R
N
------
M
-----
Q
--
G
I
E
Y
L
R
F
V
A
G
F
----------
Y
A
------------------
S
-----
S
S
S
E
I
E
E
M
V
E
R
A
T
E
I
A
--
G
L
G
-
E
K
I
K
D
R
V
S
T
Y
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
V
L
N
A
R
E
V
R
K
I
L
K
Q
A
--
S
Q
-
E
-
G
L
T
I
L
V
S
S
H
N
M
L
E
V
E
F
L
C
D
R
I
A
L
I
H
N
G
T
I
V
E
T
G
T
V
E
E
L
K
E
R
Y
K
A
Q
N
I
E
E
V
F
E
E
V
V
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
82.14
25%
-147
- C2 -
1GAJ
6
LIVG_METJA
A:
[15-247]
------------------------------------
K
Y
F
G
E
F
K
A
L
D
G
V
S
I
S
V
N
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
G
R
V
Y
F
ENKD
I
----------
T
N
K
E
P
-----
A
----------------
E
-------------
L
Y
------
H
Y
G
I
V
R
---
T
F
Q
------
T
-----
P
Q
P
L
K
E
M
T
V
L
E
N
L
L
----------
I
G
E
INPGES
P
L
N
S
L
FYKKWI
P
-----
K
E
E
E
M
V
E
K
A
F
K
I
L
E
F
L
--
K
L
S
-
H
L
Y
D
R
K
A
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
N
P
K
M
I
V
M
D
Q
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
H
V
L
E
L
--
K
A
-
K
-
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
F
N
G
Q
I
I
A
E
G
R
G
E
E
E
I
K
N
V
L
S
D
P
K
V
V
E
I
Y
I
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
81.28
27%
-153
- C2 -
3TUI
1
METN_ECOLI
C:
[41-252]
-----------------------------------------
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
------
L
VDGQELTTLS
E
S
E
L
T
-----
K
----------------
A
-------------
R
R
------
Q
I
G
M
-----
I
F
Q
------
H
-----
F
N
L
L
S
S
R
T
V
F
G
N
V
A
----------
L
P
------------------
L
ELDNT
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
--
G
L
G
-
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
--
N
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
---
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
L
G
Y
V
--------------------------------------------------------------------
46
HHSearch
79.93
28%
-140
- C2 -
1G6H
3
LIVG_METJA
A:
[4-245]
---
T
M
E
I
L
R
T
E
N
I
V
K
Y
F
G
----------------------
E
F
K
A
L
D
G
V
S
I
S
V
N
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
G
R
V
------
Y
----------
F
E
N
K
D
-----
I
----------------
T
NKE
P
A
E
L
Y
H
Y
G
I
V
R
T
------
F
Q
T
P
-----
Q
P
L
------
K
-----
E
M
T
V
L
E
N
L
L
I
G
E
I
C
----------
P
G
ES
P
L
N
S
L
F
Y
KKWI-----
P
-----
K
E
E
E
M
V
E
K
A
F
K
I
L
E
F
L
--
K
L
S
-
H
L
Y
D
R
K
A
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
N
P
K
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
H
V
L
E
L
--
K
A
-
K
-
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
F
N
G
Q
I
I
A
E
G
R
G
E
E
E
I
K
N
V
L
S
D
P
K
V
V
E
I
Y
I
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
79.69
27%
-156
- C2 -
3TUZ
1
METN_ECOLI
C:
[41-252]
-----------------------------------------
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
------
L
VDGQELTTLS
E
S
E
L
T
-----
K
----------------
A
-------------
R
R
------
Q
I
G
M
-----
I
F
Q
------
H
-----
F
N
L
L
S
S
R
T
V
F
G
N
V
A
----------
L
P
------------------
L
ELDNT
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
--
G
L
G
-
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
--
N
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
---
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
L
G
Y
V
--------------------------------------------------------------------
27
Fugue
78.93
23%
-108
- C2 -
3TUZ
3
METN_ECOLI
H:
[23-362]
-----
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
------------------
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
------
L
VDGQELTTLS
E
S
E
L
T
-----
K
----------------
A
-------------
R
R
------
Q
I
G
M
IFQHF
N
L
L
------
S
-----
S
R
T
V
F
G
N
V
A
L
P
L
E
L
----------
D
N
------------------
T
-----
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
--
G
L
G
-
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
--
N
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
---
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
V
D
-----
A
P
L
L
S
E
T
A
R
R
F
N
V
----
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
------------------
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
---------------------------------------------
15
PsiBlast_PDB
78.81
28%
-150
- C2 -
3DHW
-
METN_ECOLI
C:
[18-229]
-----------------------------------------
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
------
L
VDGQELTTLS
E
S
E
L
T
-----
K
----------------
A
-------------
R
R
------
Q
I
G
M
-----
I
F
Q
------
H
-----
F
N
L
L
S
S
R
T
V
F
G
N
V
A
----------
L
P
------------------
L
ELDNT
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
--
G
L
G
-
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
E
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
--
N
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
---
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
L
G
Y
V
--------------------------------------------------------------------
21
PsiBlast_CBE
78.46
31%
-142
- C2 -
4MKI
4
ECFA2_CALS4
A:
[26-226]
-------------------------------------------
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
NGID
I
----------
T
D
K
K
V
-----
S
L
K
D
-------------
I
-------------
R
K
------
Q
V
G
L
-----
V
F
Q
YPEYQL
F
-----
E
E
T
V
F
K
D
I
A
F
G
P
S
N
----------
L
G
------------------
L
-----
S
E
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
--
G
I
S
K
E
L
A
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
-
K
-
M
I
T
I
-
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
R
E
A
E
R
L
E
K
I
G
L
S
V
P
Q
I
T
S
L
A
R
E
L
R
K
R
G
V
P
I
P
P
D
V
L
T
I
E
E
A
K
E
H
I
L
R
Y
L
R
G
T
--------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
78.31
28%
-133
- C2 -
2PCJ
-
LOLD_AQUAE
A:
[2-222]
----
A
E
I
L
R
A
E
N
I
K
K
V
I
R
G
----------------------
Y
E
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
------
F
----------
L
E
G
K
E
-----
V
D
YTN
E
K
E
L
S
L
L
R
N
R
K
L
G
-------------
F
V
------
F
Q
F
H
-----
Y
L
I
------
P
-----
E
L
T
A
L
E
N
V
I
V
P
M
L
K
----------
M
G
------------------
K
-----
P
K
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
--
G
L
G
-
D
K
L
S
R
K
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
--
N
E
-
G
-
G
T
S
I
V
M
V
T
H
E
R
E
L
-
A
E
L
T
H
R
T
L
E
M
K
D
G
K
V
V
G
E
I
T
R
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
78.17
27%
-142
- C2 -
3GFO
1
ECFA3_CLOP1
A:
[4-236]
---
E
D
Y
I
L
K
V
E
E
L
N
Y
N
Y
S
D
---------------------
G
T
H
A
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
------
L
----------
F
D
N
K
P
-----
I
DYS
R
K
G
I
M
K
L
R
E
S
I
--
G
-------------
I
V
F
-----
Q
D
P
D
-----
N
Q
L
------
F
-----
S
A
S
V
Y
Q
D
V
S
F
G
A
V
N
----------
M
K
------------------
L
-----
P
E
D
E
I
R
K
R
V
D
N
A
L
K
R
T
--
G
I
E
-
H
L
K
D
K
P
T
H
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
--
Q
K
E
L
-
G
I
T
I
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
K
E
G
R
V
I
L
Q
G
N
P
K
E
V
F
A
E
K
E
V
I
R
K
V
N
L
R
L
P
R
I
G
H
L
M
E
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
78.07
25%
-140
- C2 -
1G9X
4
LIVG_METJA
A:
[15-247]
------------------------------------
K
Y
F
G
E
F
K
A
L
D
G
V
S
I
S
V
C
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
G
R
V
Y
F
ENKD
I
----------
T
N
K
E
P
-----
A
----------------
E
-------------
L
Y
------
H
Y
G
I
V
R
---
T
F
Q
------
T
-----
P
Q
P
L
K
E
M
T
V
L
E
N
L
L
----------
I
G
EINPGES
P
L
N
S
L
F
Y
KKWI
P
-----
K
E
E
E
M
V
E
K
A
F
K
I
L
E
F
L
--
K
L
S
-
H
L
Y
D
R
K
A
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
N
P
K
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
H
V
L
E
L
--
K
A
-
K
-
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
F
N
G
Q
I
I
A
E
G
R
G
E
E
E
I
K
N
V
L
S
D
P
K
V
V
E
I
Y
I
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
77.67
28%
-154
- C2 -
3GFO
1
ECFA3_CLOP1
A:
[22-227]
------------------------------------------
H
A
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
------
L
----------
F
D
N
K
P
IDYS
R
K
----------------
G
-------------
I
M
------
K
L
R
E
-----
S
I
G
------
I
-----
V
F
Q
D
P
D
N
Q
L
F
S
A
S
V
Y
Q
D
V
S
F
G
A
V
N
M
K
------------------
L
-----
P
E
D
E
I
R
K
R
V
D
N
A
L
K
R
T
--
G
I
E
-
H
L
K
D
K
P
T
H
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
--
Q
K
-
E
L
G
I
T
I
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
K
E
G
R
V
I
L
Q
G
N
P
K
E
V
F
A
E
K
E
V
I
R
K
V
N
L
R
L
P
R
I
G
H
L
M
E
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
77.65
28%
-142
- C2 -
1OXV
6
?
A:
[20-226]
-------------------------------------------
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
------
Y
----------
F
D
D
R
L
-----
V
----------------
A
SNGK---------
L
I
VPPEDR
K
I
G
M
-----
V
F
Q
------
T
WALYP
N
L
T
A
F
E
N
I
A
F
P
L
T
N
----------
M
K
------------------
M
-----
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
--
D
I
H
-
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
--
Q
S
-
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
I
N
E
L
E
G
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
E
E
I
F
T
Y
S
D
H
P
I
H
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
N
-------------------------------------------------------------
19
PsiBlast_PDB
77.36
28%
-141
- C2 -
1OXX
17
?
K:
[20-226]
-------------------------------------------
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
------
Y
----------
F
D
D
R
L
-----
V
----------------
A
SNGK---------
L
I
VPPEDR
K
I
G
M
-----
V
F
Q
------
T
WALYP
N
L
T
A
F
E
N
I
A
F
P
L
T
N
----------
M
K
------------------
M
-----
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
--
D
I
H
-
H
V
L
N
H
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
--
Q
S
-
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
I
N
E
L
E
G
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
E
E
I
F
T
Y
S
D
H
P
I
H
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
--------------------------------------------------------------
8
PsiBlast_PDB
77.15
31%
-140
- C2 -
4MKI
4
ECFA2_CALS4
B:
[26-226]
-------------------------------------------
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
NGID
I
----------
T
D
K
K
V
-----
S
L
K
D
-------------
I
-------------
R
K
------
Q
V
G
L
-----
V
F
Q
YPEYQL
F
-----
E
E
T
V
F
K
D
I
A
F
G
P
S
N
----------
L
G
------------------
L
-----
S
E
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
--
G
I
S
K
E
L
A
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
-
K
-
M
I
T
I
-
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
R
E
A
E
R
L
E
K
I
G
L
S
V
P
Q
I
T
S
L
A
R
E
L
R
K
R
G
V
P
I
P
P
D
V
L
T
I
E
E
A
K
E
H
I
L
R
Y
L
R
G
T
--------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
76.94
28%
-146
- C2 -
1OXU
6
?
A:
[20-226]
-------------------------------------------
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
------
Y
----------
F
D
D
R
L
-----
V
----------------
A
SNGK---------
L
I
VPPEDR
K
I
G
M
-----
V
F
Q
------
T
WALYP
N
L
T
A
F
E
N
I
A
F
P
L
T
N
----------
M
K
------------------
M
-----
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
--
D
I
H
-
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
--
Q
S
-
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
I
N
E
L
E
G
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
E
E
I
F
T
Y
S
D
H
P
I
H
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
N
-------------------------------------------------------------
10
PsiBlast_PDB
75.88
28%
-143
- C2 -
1OXS
15
?
C:
[20-226]
-------------------------------------------
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
------
Y
----------
F
D
D
R
L
-----
V
----------------
A
SNGK---------
L
I
VPPEDR
K
I
G
M
-----
V
F
Q
------
T
WALYP
N
L
T
A
F
E
N
I
A
F
P
L
T
N
----------
M
K
------------------
M
-----
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
--
D
I
H
-
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
--
Q
S
-
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
I
N
E
L
E
G
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
E
E
I
F
T
Y
S
D
H
P
I
H
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
--------------------------------------------------------------
38
HHSearch
75.80
27%
-134
- C2 -
1OXX
21
?
K:
[1-232]
----
M
V
R
I
I
V
K
N
V
S
K
V
F
K
K
--------------------
G
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
------
Y
----------
F
D
D
R
L
-----
V
ASNGKLIVPPEDRKI-
G
-------------
M
V
------
F
Q
T
W
-----
A
L
Y
------
P
-----
N
L
T
A
F
E
N
I
A
F
P
L
T
N
----------
M
K
------------------
M
-----
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
--
D
I
H
-
H
V
L
N
H
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
--
Q
S
R
L
-
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
I
N
E
L
E
G
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
E
E
I
F
T
Y
S
D
H
P
I
H
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
--------------------------------------------------------------
3
PsiBlast_PDB
75.20
30%
-140
- C2 -
2YZ2
-
ECFA2_THEMA
A:
[22-220]
-------------------------------------------
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
------
L
----------
Y
D
G
E
R
-----
K
----------------
K
-------------
G
Y
------
E
I
R
R
-----
N
I
G
------
I
-----
A
F
Q
Y
P
E
D
Q
F
F
A
E
R
V
----------
F
D
E
V
A
F
A
V
KNF---------
Y
-----
P
D
R
D
P
V
P
L
V
K
K
A
M
E
F
V
GL
D
F
D
-
S
F
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
W
--
K
T
-
L
-
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
K
V
F
D
G
T
R
M
E
F
L
E
K
Y
D
P
R
F
F
T
S
K
M
L
V
M
R
R
L
V
L
K
G
E
D
P
F
S
M
S
D
D
E
L
L
E
R
V
C
N
S
-------------------------------------------------------------------------------------------------------------------------------------------------