@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA1400: (2016-01-29 )
MTAPFNALLIANRGEIAIRIARACADLGIRSVAVFAEDDAASLHVRKADVALPLAGRGVAAYLDMDRLVALALEQGCEAIHPGYGFLAENGEFARRCQRAGIHFVGPQAEVLDLFGDKAAARALAERLEVPLVAGINRAVSVEEAEAFLEGLGDGAAVMLKALAGGGGRGMRAVEEVAQLADAYRRCRAEAQAAFGRDELYVEQRVARARHIEVQVLGDGSGAVSHLWERDCSLQRRQQKLLEIAPSPDLPEATREALIDCALRMAGAVRYRGIGTFEFLVDDERPGRFYFMEANPRIQVEHTVTEEVTGVDLLHAQLRLAAGMELAALGLERPPAIGGCAVQLRINLETLAADGSARPAVGTIGAYEPPSGPGLRVDGYGYAGYRVSPSYDSLLAKLVVRGADYPAALRRAYRALCEFRLEGVASNLDLLRNLLLHPAVQANRVDTRFVESHLETLLAPIPASHPRLRAECPLAEDAAPARVEAPLGSLPLSAPSSGVLVALEVADGERVRAGQRVAILEAMKMEFEVKAPGGGIVRRLAASLGEPLEEGATLLFLEPTEDDDEQAPTEQALDLAHIRADLAEVLERQAALGDERRPQALARRRKTGQRTARENVLDLLDEGSFSEYGGFALAAQRRRRSAEELLELSPADGLVAGTGTVGAASFGVQAARCLVLAYDYTVFAGTQGVMNHKKTDRLLGLAEQWRLPLVLFAEGGGGRPGDTDFVGVAGLDCHTFVGMARLSGLVPLVGVVSGRCFAGNAALLGCCDVIIATRDATIGMAGPAMIEGGGLGRFAAEEVGPTGVQGPNGVIDVLVEDEAEAVAVARRYLGYFQGPLPDWSCADQRELRHLVPENRLRAYDIRQAIEVLADRGSVLELRRQFAPGLVTALLRIEGRAFGLIANNPGHLGGAIDAAAGDKAARFMQLCDAFDIPIVSLCDTPGFMVGPEAEKQATVRHVSRMFVSAASLTVPFFTVVLRKGYGLGAQAMAAGSFHSPLFTVAWPSGEFGAMGLEGAVRLGFAKELAAEEDPQRREALFRGMVDKAYRNGKALNMASYLEIDAVIDPAETRAWLLRGLAVAGEPAPRAGRKRPFVDTW
Atome Classification :
(53 SA)
.........10........20........30........40........50.---...-..-.---.60........70........80........90........100.......110.......120.......130....--..-.--140.-........150.......160.......170.......180.......190.......200.......210.......220....---...230.......240.......250.......260......---.270.......280.......290.......300.......310.......320..----.....330--..------------....----...340.......350.......360.......370-.......-.380........390.......400.........410.......420.......430.......440.......450.......460...----------------------.-----.--------.------.----470----------.---------------------.--------.---------.-------------..-------.----------..--------------------480---------------.........490.......500....-...510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTAP
F
N
A
L
L
I
ANR
G
E
I
A
I
R
I
A
R
A
C
A
DLGI
R
S
V
A
V
F
AEDDAA
S
L
H
V
R
KA
D
V
AL---PLA-GR-
G
---
V
A
A
Y
L
D
M
D
R
L
V
A
L
A
L
E
QGCEAIHPGYGFLAEN
G
E
F
A
R
R
C
Q
RAG
I
H
F
VGP
Q
A
E
V
L
D
L
FG
D
K
A
A
A
R
A
L
A
E
R
LEV
P
L
V
AGI--NR-A--V--
S
-
V
E
E
A
E
A
F
L
E
GLGD
G
A
A
V
M
L
K
A
L
AGGGGR
G
M
R
A
V
E
E
V
A
Q
L
A
D
A
Y
R
R
C
R
A
E
A
Q
A
AFG
R
D
E
L
Y
V
E
Q
R
V
AR
A
R
H
I
E
V
Q
V
LGDGS
G
A
V
S
H
---
L
W
E
RD
C
S
L
Q
R
R
Q
Q
K
L
L
EIAPSPDL
P
E
A
T
R
E
A
L
I
D
C
A
L
R
M
AG
A
---
V
R
Y
RGI
G
T
F
E
F
L
VDDERP
G
R
F
Y
F
M
EAN
P
R
I
Q
V
E
H
TVTEEVT
G
V
D
L
L
H
A
Q
L
R
L
AAGM----
E
L
A
A
LG----LE------------RPPA----IG
G
C
A
V
Q
L
R
I
N
L
E
T
L
AADGSARPAVGTIGAYEPP-S-GPG
L
R
V
D-GY-GYAG
Y
R
VSP
S
Y
D
S
L
L
A
K
L
V
V--RGAD
Y
P
A
A
L
R
R
A
Y
R
A
L
C
E
F
R
L
E
G
V
AS
N
L
D
L
L
R
N
L
L
LHPAVQANR
V
D
T
R
F
V
E
S
H
L
E
T
L
LAPIPASH----------------------P-----R--------L------R----A------------E---------------------C--------P---------L-------------AE-------D----------AA--------------------P-----------------ARVEAPLGSLPLSAPSS
G
V
L
V
A
L
EVA-DGERVRAG
Q
R
V
A
I
L
E
A
M
K
M
E
F
E
V
KAPG
G
G
I
V
R
R
L
A
A
SLG
E
P
L
EEG
A
T
L
L
F
L
EPTEDDDEQA
P
T
E
Q
A
L
D
L
A
H
I
R
A
D
L
A
E
V
L
E
R
Q
A
ALGDER
R
P
Q
A
L
A
R
R
R
KTGQ
R
T
A
R
E
N
V
L
D
L
LDEGSFSEYGG
F
A
L
A
A
Q
R
R
RR
S
A
E
E
L
L
ELSPAD
G
L
V
AGTGTV
G
A
A
S
F
G
V
Q
A
A
R
C
L
V
L
A
Y
D
Y
T
V
FAGTQGVMNH
K
K
T
D
R
L
L
G
L
A
E
QWRL
P
L
V
L
F
A
EGGGGRPGDT
D
F
V
G
V
AGL
D
C
H
T
F
V
G
M
A
R
L
S
G
L
V
P
L
V
G
VVSGRCFAGN
A
A
L
L
G
C
C
D
V
I
I
ATRDATIGMAGP
A
M
IEGGGLG
R
F
A
A
E
EVGPTGVQGPN
G
V
I
D
V
L
VEDE
A
E
A
V
A
V
A
R
R
Y
L
G
Y
FQGPLPDWSCA
D
Q
R
E
L
R
H
LV
P
E
NR
L
R
A
Y
D
I
R
Q
A
I
E
V
L
ADR
G
S
V
L
E
L
R
R
Q
FA
P
G
L
V
T
A
L
L
RIEG
R
A
F
G
L
I
ANNPGHLGGAIDAAA
G
D
K
A
A
R
F
M
Q
L
C
D
AFDI
P
I
V
S
LCDTPGFMVGP
E
A
E
K
Q
A
T
V
R
H
V
S
R
M
F
V
S
A
A
SL
T
V
P
F
F
T
V
V
L
RKGYGL
G
A
Q
A
MAAGSFHS
P
L
F
T
V
AWPSGEFGAMGL
E
G
A
VRLG
F
A
K
E
LAAEE
D
P
Q
R
R
E
A
L
F
R
G
M
V
D
K
A
YRNGKALN
M
A
S
Y
L
E
I
D
A
VI
D
P
A
E
T
R
A
W
L
L
R
G
L
AVAGEPAPRAGRKRPFVDTW
1
PsiBlast_PDB
94.45
53%
-107
- C2 -
4RCN
-
?
A:
[3-1071]
--
A
---
S
L
L
V
A
N
R
G
E
I
A
L
R
I
I
R
T
A
T
E
L
G
M
R
T
V
A
V
Y
A
A
D
D
A
H
S
P
H
V
H
A
A
D
E
A
M
---
P
L
P
-
G
S
-
G
---
P
P
A
Y
L
N
Q
A
A
L
L
A
V
A
E
N
T
G
A
T
L
I
H
P
G
Y
G
F
L
S
E
N
A
E
F
A
K
A
C
A
A
A
S
H
T
F
V
G
P
D
G
R
V
L
E
L
L
G
N
K
T
A
A
R
R
A
A
I
A
A
G
V
P
T
L
A
A
-----------------------------------------------------------------------------
L
L
G
D
A
R
H
I
E
V
Q
V
V
A
A
P
A
G
H
Q
T
H
A
L
A
V
G
D
R
D
C
S
M
Q
R
R
Y
Q
K
L
I
E
I
A
P
A
Q
G
L
S
E
E
L
R
R
A
L
H
Q
A
A
V
R
L
C
A
R
---
V
G
L
R
G
L
A
T
V
E
F
L
V
S
G
E
R
---
F
V
F
L
E
V
N
P
R
I
Q
V
E
H
T
V
T
E
Q
T
T
G
L
D
L
V
A
V
Q
L
A
I
A
G
G
E
----
S
Y
Y
R
L
G
----
L
P
AGIASDG
T
E
V
I
G
E
P
A
A
----
Q
R
G
I
A
I
Q
L
R
V
N
A
E
T
F
G
A
D
F
S
V
L
P
S
A
G
T
L
T
A
F
C
P
P
-
S
-
G
P
G
V
R
V
D
-
T
Y
-
G
R
P
G
L
V
V
S
P
Q
Y
D
S
L
L
A
K
V
I
V
A
V
H
G
S
S
W
R
A
A
M
R
K
A
D
T
A
L
S
E
F
G
V
E
G
V
A
T
N
I
G
F
L
R
R
L
L
A
E
Q
R
L
E
T
G
W
V
N
T
D
F
V
D
E
K
L
P
E
L
A
A
A
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----------------
G
A
V
E
L
Y
P
G
E
D
A
L
R
A
Q
L
A
G
T
V
V
--
E
V
A
P
E
G
A
D
Y
P
A
G
A
Q
L
V
V
L
E
A
M
K
M
Q
H
V
L
A
A
P
D
A
L
R
T
V
R
V
L
V
T
P
G
Q
V
V
G
T
G
D
P
L
L
V
F
T
R
-------------
T
D
L
D
L
T
R
A
D
L
D
E
V
I
E
R
H
A
R
T
L
D
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G
R
P
D
A
V
A
K
R
H
R
Q
G
R
R
T
A
R
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N
I
D
D
L
V
D
P
G
S
F
V
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Y
G
A
L
A
I
A
A
Q
R
S
R
R
S
E
E
D
L
I
A
N
T
P
A
D
G
L
V
A
G
L
A
T
V
G
A
D
R
F
G
P
A
A
A
Q
A
V
V
A
S
Y
D
Y
T
V
L
A
G
T
Q
G
M
R
N
H
A
K
T
D
R
V
F
D
L
A
A
R
K
R
L
P
V
V
L
F
A
E
G
G
--
R
P
G
D
T
---
G
A
A
G
L
D
V
P
T
F
R
M
L
A
G
L
R
G
R
V
P
L
V
S
V
V
S
G
R
C
F
A
G
N
A
A
L
A
G
V
C
D
V
I
I
A
T
P
D
A
N
I
G
M
G
G
P
A
M
I
E
G
G
G
L
G
V
Y
P
P
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A
I
G
P
I
A
V
Q
R
R
N
G
V
V
G
L
V
A
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D
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A
H
A
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S
L
A
K
Q
Y
L
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Y
F
Q
G
R
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D
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W
Q
A
P
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P
R
V
A
R
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V
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P
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N
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L
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A
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D
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S
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L
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G
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G
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K
A
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A
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L
C
D
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P
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F
M
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G
P
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T
Q
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R
R
F
G
R
M
F
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L
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A
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L
T
V
P
L
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M
I
I
L
R
K
G
Y
G
L
G
A
M
A
M
A
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G
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F
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A
P
Q
F
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V
A
W
P
T
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E
I
G
G
M
G
L
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S
A
V
R
L
G
Y
R
------
T
D
P
A
E
R
Q
N
L
F
D
R
L
V
A
A
A
Y
Q
H
G
K
A
L
R
A
A
T
T
F
E
L
D
D
V
I
D
P
A
A
S
R
A
W
I
T
R
L
S
--------------------
140
HHSearch
66.29
42%
-96
- C2 -
3U9T
-
?
A:
[47-639]
--
R
S
I
Q
R
L
L
V
A
N
R
G
E
I
A
C
R
V
M
R
S
A
R
A
L
G
I
G
S
V
A
V
H
S
D
I
D
R
H
A
R
H
V
A
E
A
D
I
A
V
---
D
L
G
-
G
A
K
P
---
A
D
S
Y
L
R
G
D
R
I
I
A
A
A
L
A
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A
Q
A
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P
G
Y
G
F
L
S
E
N
A
D
F
A
R
A
C
E
E
A
G
L
L
F
L
G
P
P
A
A
A
I
D
A
M
G
S
K
S
A
A
K
A
L
M
E
E
A
G
V
P
L
V
P
G
Y
--
H
--
G
E
A
Q
--
D
-
L
E
T
F
R
R
E
A
G
R
I
--
G
Y
P
V
L
L
K
A
A
A
------
M
K
V
V
E
R
E
A
E
L
A
E
A
L
S
S
A
Q
R
--------
A
R
M
L
V
E
K
Y
L
L
K
P
R
H
V
E
I
Q
V
F
A
D
R
H
G
H
C
L
Y
---
L
N
E
R
D
C
S
I
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
L
G
A
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L
R
R
A
M
G
E
A
A
V
R
A
A
Q
A
---
I
G
Y
V
G
A
G
T
V
E
F
L
L
D
E
R
--
G
Q
F
F
F
M
E
M
N
T
R
L
Q
V
E
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P
V
T
E
A
I
T
G
L
D
L
V
A
W
Q
I
R
V
A
R
G
E
----
A
L
P
L
T
Q
----
E
--------------
Q
V
P
----
L
N
G
H
A
I
E
V
R
L
Y
A
E
D
P
E
G
--
D
F
L
P
A
S
G
R
L
M
L
Y
R
E
A
A
A
-
G
P
G
R
R
V
D
-
S
G
-
V
R
E
G
D
E
V
S
P
F
Y
D
P
M
L
A
K
L
I
A
--
W
G
E
T
R
E
E
A
R
Q
R
L
L
A
M
L
A
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S
V
G
G
L
R
T
N
L
A
F
L
R
R
I
L
G
H
P
A
F
A
A
A
E
L
D
T
G
F
I
A
R
H
Q
D
D
L
L
P
A
P
Q
A
L
P
E
H
F
W
Q
A
A
A
E
A
W
L
Q
S
E
PGHRRD-
D
DPH--
S
--------
P
WSRNDG
W
----
R
SA----------
L
A
R
E
S
D
L
MLRCRDERRC
V
R
L
R
H
A
--------
S
---------
P
SQ
Y
R
L
D
GD
D
L
V
S
R
V
D
-------
G
V
T
R
R
S
A
A
L
R
R
G
R
Q
L
F
L
E
W
EG
E
-----------
L
L
A
I
E
A
V
D
PIA-------
E
A
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
HHSearch
61.62
43%
-98
- C2 -
2DZD
-
?
A:
[3-458]
-
T
R
R
I
R
K
V
L
V
A
N
R
G
E
I
A
I
R
V
F
R
A
C
T
E
L
G
I
R
T
V
A
I
Y
S
K
E
D
V
G
S
Y
H
R
Y
K
A
D
E
A
Y
---
L
V
G
-
E
G
-
K
K
P
-
I
E
A
Y
L
D
I
E
G
I
I
E
I
A
K
A
H
D
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
I
Q
F
A
K
R
C
R
E
E
G
I
I
F
I
G
P
N
E
N
H
L
D
M
F
G
D
K
V
K
A
R
H
A
A
V
N
A
G
I
P
V
I
P
G
S
DG
P
--
V
--
D
--
G
-
L
E
D
V
V
A
F
A
E
A
H
--
G
Y
P
I
I
I
K
A
A
L
G
G
G
G
R
G
M
R
I
V
R
S
K
S
E
V
K
E
A
F
E
R
A
K
S
E
A
K
A
A
F
G
S
D
E
V
Y
V
E
K
L
I
E
N
P
K
H
I
E
V
Q
I
L
G
D
Y
E
G
N
I
V
H
---
L
Y
E
R
D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
S
L
S
D
E
L
R
Q
R
I
C
E
A
A
V
Q
L
M
R
S
---
V
G
Y
V
N
A
G
T
V
E
F
L
V
S
G
D
---
E
F
Y
F
I
E
V
N
P
R
I
Q
V
E
H
T
I
T
E
M
I
T
G
I
D
I
V
Q
S
Q
I
L
I
A
D
G
C
----
S
L
H
S
H
E
VGIP
K
Q
------------
E
D
I
R
----
I
N
G
Y
A
I
Q
S
R
V
T
T
E
D
P
L
N
--
N
F
M
P
D
T
G
K
I
M
A
Y
R
S
G
-
G
-
G
F
G
V
R
L
D
-
A
G
N
G
F
Q
G
A
V
I
T
P
Y
Y
D
S
L
L
V
K
L
S
T
--
W
A
L
T
F
E
Q
A
A
R
K
M
L
R
N
L
R
E
F
R
I
R
G
I
K
T
N
I
P
F
L
E
N
V
V
Q
H
P
K
F
L
S
G
E
Y
D
T
S
F
I
D
T
T
P
E
L
F
V
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
61.30
42%
-99
- C2 -
2DZD
-
?
A:
[9-460]
-------
V
L
V
A
N
R
G
E
I
A
I
R
V
F
R
A
C
T
E
L
G
I
R
T
V
A
I
Y
S
K
E
D
V
G
S
Y
H
R
Y
K
A
D
E
A
Y
----
L
V
-
G
E
-
G
KK
P
I
E
A
Y
L
D
I
E
G
I
I
E
I
A
K
A
H
D
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
I
Q
F
A
K
R
C
R
E
E
G
I
I
F
I
G
P
N
E
N
H
L
D
M
F
G
D
K
V
K
A
R
H
A
A
V
N
A
G
I
P
V
I
P
G
S
--
D
G
-
P
--
V
--
D
G
L
E
D
V
V
A
F
A
E
A
--
H
G
Y
P
I
I
I
K
A
A
L
G
G
G
G
R
G
M
R
I
V
R
S
K
S
E
V
K
E
A
F
E
R
A
K
S
E
A
K
A
A
F
G
S
D
E
V
Y
V
E
K
L
I
E
N
P
K
H
I
E
V
Q
I
L
G
D
Y
E
G
N
I
V
H
---
L
Y
E
R
D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
S
L
S
D
E
L
R
Q
R
I
C
E
A
A
V
Q
L
M
R
S
---
V
G
Y
V
N
A
G
T
V
E
F
L
V
S
G
D
---
E
F
Y
F
I
E
V
N
P
R
I
Q
V
E
H
T
I
T
E
M
I
T
G
I
D
I
V
Q
S
Q
I
L
I
A
D
G
C
----
S
L
H
S
H
E
----
V
G
------------
I
P
K
Q
ED
I
R
I
N
G
Y
A
I
Q
S
R
V
T
T
E
D
P
L
--
N
N
F
M
P
D
T
G
K
I
M
A
Y
R
S
G
-
G
-
G
F
G
V
R
L
D
A
G
N
-
G
F
Q
G
A
V
I
T
P
Y
Y
D
S
L
L
V
K
L
S
T
--
W
A
L
T
F
E
Q
A
A
R
K
M
L
R
N
L
R
E
F
R
I
R
G
I
K
T
N
I
P
F
L
E
N
V
V
Q
H
P
K
F
L
S
G
E
Y
D
T
S
F
I
D
T
T
P
E
L
F
V
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
HHSearch
61.09
36%
-92
- C2 -
3N6R
1
?
A:
[2-681]
----
F
N
K
I
L
I
A
N
R
G
E
I
A
C
R
V
I
K
T
A
R
K
M
G
I
S
T
V
A
I
Y
S
D
A
D
K
Q
A
L
H
V
Q
M
A
D
E
A
V
---
H
I
G
-
P
P
P
A
---
N
Q
S
Y
I
V
I
D
K
V
M
A
A
I
R
A
T
G
A
Q
A
V
H
P
G
Y
G
F
L
S
E
N
S
K
F
A
E
A
L
E
A
E
G
V
I
F
V
G
P
P
K
G
A
I
E
A
M
G
D
K
I
T
S
K
K
I
A
Q
E
A
N
V
S
T
V
P
G
------------------------------------------------------------------------------
V
T
Q
P
R
H
I
E
I
Q
V
L
C
D
S
H
G
N
G
I
Y
---
L
G
E
R
E
C
S
I
Q
R
R
N
Q
K
V
V
E
E
A
P
S
P
F
L
D
E
A
T
R
R
A
M
G
E
Q
A
V
A
L
A
K
A
---
V
G
Y
A
S
A
G
T
V
E
F
I
V
D
G
Q
--
K
N
F
Y
F
L
E
M
N
T
R
L
Q
V
E
H
P
V
T
E
L
I
T
G
V
D
L
V
E
Q
M
I
R
V
A
A
G
E
----
P
L
S
I
T
Q
----
G
--------------
D
V
K
----
L
T
G
W
A
I
E
N
R
L
Y
A
E
D
P
Y
R
G
--
F
L
P
S
I
G
R
L
T
R
Y
R
P
P
-
A
E-
A
A
V
R
N
D
-
T
G
-
V
Y
E
G
G
E
I
S
M
Y
Y
D
P
M
I
A
K
L
C
T
--
W
A
P
T
R
A
A
A
I
E
A
M
R
I
A
L
D
S
F
E
V
E
G
I
G
H
N
L
P
F
L
S
A
V
M
D
H
P
K
F
I
S
G
D
M
T
T
A
F
I
A
E
E
Y
P
E
G
F
E
G
V
N
L
P
E
T
D
L
R
R
V
A
A
A
A
A
A
M
H
R
V
A
E
I
R
R
T
R
VSGRM
D
NH
E
R
R
V
G
T
E
------
W
V
V
T
L
Q
GADFP
V
T
I
A
A
D
H
D
---------------------
G
S
T
V
S
F
DDG
S
S
M
R
V
T
S
DWT
P
-------------
G
D
Q
L
A
N
L
M
V
D
----------
G
A
P
L
V
L
K
V
G
K
I
SG
G
F
R
I
R
T
R
G
A
D
L
K
V
H
V
R
T
P
R
Q
A
E
L
A
R
L
M
P
E
K
L
P
P
D
T
S
K
M
L
L
C
P
M
P
G
L
I
V
K
V
D
V
E
-
V
G
Q
E
V
Q
E
G
Q
A
L
C
T
I
E
A
M
K
M
E
N
I
L
R
A
E
K
K
G
V
V
A
K
I
N
A
S
A
G
N
S
L
A
V
D
D
V
I
M
E
F
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
60.85
40%
-91
- C2 -
2VPQ
4
?
B:
[4-444]
-------
V
L
I
A
N
R
G
E
I
A
V
R
I
I
R
A
C
R
D
L
G
I
Q
T
V
A
I
Y
S
E
G
D
K
D
A
L
H
T
Q
I
A
D
E
A
Y
CVG
P
T
L
-
S
K
-
D
-----
S
Y
L
N
I
P
N
I
L
S
I
A
T
S
T
G
C
D
G
V
H
P
G
Y
G
F
L
A
E
N
A
D
F
A
E
L
C
E
A
C
Q
L
K
F
I
G
P
S
Y
Q
S
I
Q
K
M
G
I
K
D
V
A
K
A
E
M
I
K
A
N
V
P
V
V
P
G
S
--
D
G
-
L
--
M
--
K
D
V
S
E
A
K
K
I
A
K
K
I
G
--
Y
P
V
I
I
K
A
T
A
G
G
G
G
K
G
I
R
V
A
R
D
E
K
E
L
E
T
G
F
R
M
T
E
Q
E
A
Q
T
A
F
G
N
G
G
L
Y
M
E
K
F
I
E
N
F
R
H
I
E
I
Q
I
V
G
D
S
Y
G
N
V
I
H
---
L
G
E
R
D
C
T
I
Q
R
R
M
Q
K
L
V
E
E
A
P
S
P
I
L
D
D
E
T
R
R
E
M
G
N
A
A
V
R
A
A
K
A
---
V
N
Y
E
N
A
G
T
I
E
F
I
Y
-
D
L
N
D
N
K
F
Y
F
M
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
V
T
G
I
D
L
V
K
L
Q
L
Q
V
A
M
G
D
----
V
L
P
Y
------
K
Q
------------
E
D
I
K
----
L
T
G
H
A
I
E
F
R
I
N
A
E
N
P
Y
K
N
--
F
M
P
S
P
G
K
I
E
Q
Y
L
A
P
-
G
-
G
Y
G
V
R
I
E
-
S
A
-
C
Y
T
N
Y
T
I
P
P
Y
Y
D
S
M
V
A
K
L
I
I
--
H
E
P
T
R
D
E
A
I
M
A
G
I
R
A
L
S
E
F
V
V
L
G
I
D
T
T
I
P
F
H
I
K
L
L
N
N
D
I
F
R
S
G
K
F
N
T
N
F
L
E
Q
N
S
I
M
N
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
60.45
43%
-113
- C2 -
4QSK
1
?
A:
[1-461]
M
M
N
R
I
K
K
V
L
V
A
N
R
G
E
I
A
I
R
V
M
R
A
C
T
E
L
K
I
K
T
V
A
I
Y
S
Q
E
D
T
G
S
F
H
R
Y
K
S
D
E
A
Y
----
L
V
-
G
A
-
G
KK
P
I
D
A
Y
L
D
I
E
N
I
I
E
I
A
K
E
S
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
I
E
F
A
R
R
C
E
Q
E
G
I
I
F
V
G
P
K
S
K
H
L
D
M
F
G
D
K
I
K
A
K
E
Q
A
L
L
A
D
I
P
V
I
P
------------------------------------------------------------------------------
C
V
M
N
P
K
H
I
E
V
Q
I
L
G
D
T
H
G
N
I
V
H
---
L
F
E
R
D
C
S
I
Q
R
R
H
Q
K
V
V
E
V
A
P
C
N
A
I
T
S
E
L
R
N
R
I
C
D
A
A
V
K
L
M
K
N
---
V
D
Y
I
N
A
G
T
V
E
F
L
V
E
G
D
---
D
F
Y
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
I
T
G
I
D
I
V
Q
S
Q
L
F
I
A
D
G
Y
ALHD
Q
L
V
A
I
P
----
K
Q
------------
E
D
I
H
----
I
H
G
S
A
I
Q
S
R
I
T
T
E
D
P
L
--
N
N
F
M
P
D
T
G
R
V
D
T
Y
R
S
T
-
G
-
G
F
G
V
R
L
D
A
G
N
-
G
F
Q
G
T
V
V
T
P
F
Y
D
S
L
L
V
K
L
C
T
--
W
G
M
T
F
E
Q
A
T
R
K
M
R
R
N
L
I
E
F
R
I
R
G
V
K
T
N
I
P
F
L
L
N
V
V
R
H
P
D
F
A
S
G
N
Y
N
T
S
F
I
D
T
T
P
E
L
F
K
F
P
H
I
R
D
R
----------------------
G
-----
T
--------
K
------
T
----
L
------------
R
---------------------
Y
--------
I
---------
G
-------------
N
V
-------
T
----------
V
N
--------------------
G
-----------------
F
P
G
I
K
H
R
D
K
P
V
Y
A
E
P
R
L
P
K
I
P
Y
G
S
Q
I
-
S
P
G
T
K
Q
I
L
D
A
K
G
P
E
G
V
V
D
W
V
K
K
Q
E
E
V
L
L
T
D
T
T
L
R
D
A
H
Q
S
L
L
A
T
R
V
R
S
K
D
I
F
Q
I
A
D
A
M
A
H
L
L
P
N
M
F
S
F
E
M
W
G
G
A
T
F
D
V
A
Y
R
F
L
N
E
D
P
W
V
R
L
E
T
L
R
K
Q
I
P
N
V
M
F
Q
M
L
L
R
G
A
N
A
V
G
Y
K
N
Y
P
D
N
V
I
R
E
F
V
K
Q
S
A
Q
S
G
V
D
V
F
R
V
F
D
S
L
N
W
I
K
G
M
E
V
S
I
D
A
V
R
E
A
G
K
I
V
E
A
A
I
C
Y
T
G
D
I
D
D
D
T
R
T
K
Y
T
I
D
Y
Y
K
D
M
A
K
E
L
V
A
Q
G
T
H
I
L
G
I
K
D
M
A
G
L
L
K
P
Q
A
A
Y
R
L
I
G
E
L
K
D
T
V
D
V
P
I
H
L
H
T
H
D
T
S
G
N
G
I
Y
T
Y
A
A
A
V
S
A
G
V
D
I
V
D
V
A
S
S
A
M
S
G
A
T
S
Q
P
S
M
T
G
L
Y
Y
G
L
V
N
G
N
R
Q
T
N
L
D
A
Q
N
S
Q
I
I
N
H
Y
W
E
D
V
R
H
Y
Y
K
D
F
D
N
A
L
N
S
P
Q
T
E
V
Y
I
H
E
M
P
G
G
Q
Y
T
N
L
Q
Q
Q
A
I
A
V
G
L
G
D
R
W
D
E
V
K
E
M
Y
T
V
V
N
Q
M
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
L
A
L
F
M
V
Q
N
E
L
S
E
E
D
V
Y
E
K
G
D
T
I
D
F
P
D
S
V
I
E
F
F
M
G
E
I
G
Q
P
Y
G
G
F
P
E
K
L
Q
K
L
V
L
K
G
R
T
P
L
T
D
R
P
G
A
L
M
E
P
V
N
F
V
E
V
K
A
E
L
K
E
K
M
G
Y
E
P
T
E
K
D
V
I
S
Y
I
L
Y
P
K
V
F
L
D
Y
Q
E
M
I
N
K
Y
G
D
V
T
V
L
D
T
P
T
F
Y
K
G
M
R
L
G
E
T
I
E
V
E
L
E
K
G
K
I
L
L
I
K
L
N
S
I
G
E
P
I
A
D
G
T
R
V
I
Y
F
E
L
N
G
Q
P
R
E
I
N
I
Q
D
M
N
V
Q
A
R
R
K
I
D
T
T
N
P
E
H
V
G
A
T
M
T
G
S
V
I
Q
V
V
V
K
K
G
D
S
V
K
K
21
PsiBlast_CBE
60.21
43%
-112
- C2 -
4QSK
1
?
B:
[1-461]
M
M
N
R
I
K
K
V
L
V
A
N
R
G
E
I
A
I
R
V
M
R
A
C
T
E
L
K
I
K
T
V
A
I
Y
S
Q
E
D
T
G
S
F
H
R
Y
K
S
D
E
A
Y
----
L
V
-
G
A
-
G
KKP
I
D
A
Y
L
D
I
E
N
I
I
E
I
A
K
E
S
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
I
E
F
A
R
R
C
E
Q
E
G
I
I
F
V
G
P
K
S
K
H
L
D
M
F
G
D
K
I
K
A
K
E
Q
A
L
L
A
D
I
P
V
I
P
------------------------------------------------------------------------------
C
V
M
N
P
K
H
I
E
V
Q
I
L
G
D
T
H
G
N
I
V
H
---
L
F
E
R
D
C
S
I
Q
R
R
H
Q
K
V
V
E
V
A
P
C
N
A
I
T
S
E
L
R
N
R
I
C
D
A
A
V
K
L
M
K
N
---
V
D
Y
I
N
A
G
T
V
E
F
L
V
E
G
D
---
D
F
Y
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
I
T
G
I
D
I
V
Q
S
Q
L
F
I
A
D
G
Y
ALHD
Q
L
V
A
I
P
----
K
Q
------------
E
D
I
H
----
I
H
G
S
A
I
Q
S
R
I
T
T
E
D
P
L
--
N
N
F
M
P
D
T
G
R
V
D
T
Y
R
S
T
-
G
-
G
F
G
V
R
L
D
A
G
N
-
G
F
Q
G
T
V
V
T
P
F
Y
D
S
L
L
V
K
L
C
T
--
W
G
M
T
F
E
Q
A
T
R
K
M
R
R
N
L
I
E
F
R
I
R
G
V
K
T
N
I
P
F
L
L
N
V
V
R
H
P
D
F
A
S
G
N
Y
N
T
S
F
I
D
T
T
P
E
L
F
K
F
P
H
I
R
D
R
----------------------
G
-----
T
--------
K
------
T
----
L
------------
R
---------------------
Y
--------
I
---------
G
-------------
N
V
-------
T
----------
V
N
--------------------
G
-----------------
F
P
G
I
K
H
R
D
K
P
V
Y
A
E
P
R
L
P
K
I
P
Y
G
S
Q
I
-
S
P
G
T
K
Q
I
L
D
A
K
G
P
E
G
V
V
D
W
V
K
K
Q
E
E
V
L
L
T
D
T
T
L
R
D
A
H
Q
S
L
L
A
T
R
V
R
S
K
D
I
F
Q
I
A
D
A
M
A
H
L
L
P
N
M
F
S
F
E
M
W
G
G
A
T
F
D
V
A
Y
R
F
L
N
E
D
P
W
V
R
L
E
T
L
R
K
Q
I
P
N
V
M
F
Q
M
L
L
R
G
A
N
A
V
G
Y
K
N
Y
P
D
N
V
I
R
E
F
V
K
Q
S
A
Q
S
G
V
D
V
F
R
V
F
D
S
L
N
W
I
K
G
M
E
V
S
I
D
A
V
R
E
A
G
K
I
V
E
A
A
I
C
Y
T
G
D
I
D
D
D
T
R
T
K
Y
T
I
D
Y
Y
K
D
M
A
K
E
L
V
A
Q
G
T
H
I
L
G
I
K
D
M
A
G
L
L
K
P
Q
A
A
Y
R
L
I
G
E
L
K
D
T
V
D
V
P
I
H
L
H
T
H
D
T
S
G
N
G
I
Y
T
Y
A
A
A
V
S
A
G
V
D
I
V
D
V
A
S
S
A
M
S
G
A
T
S
Q
P
S
M
T
G
L
Y
Y
G
L
V
N
G
N
R
Q
T
N
L
D
A
Q
N
S
Q
I
I
N
H
Y
W
E
D
V
R
H
Y
Y
K
D
F
D
N
A
L
N
S
P
Q
T
E
V
Y
I
H
E
M
P
G
G
Q
Y
T
N
L
Q
Q
Q
A
I
A
V
G
L
G
D
R
W
D
E
V
K
E
M
Y
T
V
V
N
Q
M
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
L
A
L
F
M
V
Q
N
E
L
S
E
E
D
V
Y
E
K
G
D
T
I
D
F
P
D
S
V
I
E
F
F
M
G
E
I
G
Q
P
Y
G
G
F
P
E
K
L
Q
K
L
V
L
K
G
R
T
P
L
T
D
R
P
G
A
L
M
E
P
V
N
F
V
E
V
K
A
E
L
K
E
K
M
G
Y
E
P
T
E
K
D
V
I
S
Y
I
L
Y
P
K
V
F
L
D
Y
Q
E
M
I
N
K
Y
G
D
V
T
V
L
D
T
P
T
F
Y
K
G
M
R
L
G
E
T
I
E
V
E
L
E
K
G
K
I
L
L
I
K
L
N
S
I
G
E
P
I
A
D
G
T
R
V
I
Y
F
E
L
N
G
Q
P
R
E
I
N
I
Q
D
M
N
V
Q
A
R
R
K
I
D
T
T
N
P
E
H
V
G
A
T
M
T
G
S
V
I
Q
V
V
V
K
K
G
D
S
V
K
K
149
HHSearch
60.05
43%
-94
- C2 -
1ULZ
-
?
A:
[1-443]
---
M
V
N
K
V
L
V
A
N
R
G
E
I
A
V
R
I
I
R
A
C
K
E
L
G
I
P
T
V
A
I
Y
N
E
V
E
S
T
A
R
H
V
K
L
A
D
E
A
Y
---
M
I
G
-
T
D
-
P
---
L
D
T
Y
L
N
K
Q
R
I
I
N
L
A
L
E
V
G
A
D
A
I
H
P
G
Y
G
F
L
A
E
N
A
E
F
A
K
M
C
E
E
A
G
I
T
F
I
G
P
H
W
K
V
I
E
L
M
G
D
K
A
R
S
K
E
V
M
K
K
A
G
V
P
V
V
P
G
S
DG
V
--
L
--
K
--
S
-
L
E
E
A
K
A
L
A
R
E
I
--
G
Y
P
V
L
L
K
A
T
A
G
G
G
G
R
G
I
R
I
C
R
N
E
E
E
L
V
K
N
Y
E
Q
A
S
R
E
A
E
K
A
F
G
R
G
D
L
L
L
E
K
F
I
E
N
P
K
H
I
E
Y
Q
V
L
G
D
K
H
G
N
V
I
H
---
L
G
E
R
D
C
S
I
Q
R
R
N
Q
K
L
V
E
I
A
P
S
L
I
L
T
P
E
K
R
E
Y
Y
G
N
I
V
T
K
A
A
K
E
---
I
G
Y
Y
N
A
G
T
M
E
F
I
A
D
Q
E
--
G
N
L
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
S
E
M
V
T
G
I
D
I
V
K
W
Q
I
K
I
A
A
G
E
----
P
L
T
I
K
Q
----
E
--------------
D
V
K
----
F
N
G
Y
A
I
E
C
R
I
N
A
E
D
P
K
K
--
N
F
A
P
S
T
R
V
I
E
R
Y
Y
V
P
-
G
-
G
F
G
I
R
V
E
-
H
A
-
A
A
R
G
F
E
V
T
P
Y
Y
D
S
M
I
A
K
L
I
T
--
W
A
P
T
W
D
E
A
V
E
R
M
R
A
A
L
E
T
Y
E
I
T
G
V
K
T
T
I
P
L
L
I
N
I
M
K
E
K
D
F
K
A
G
K
F
T
T
K
Y
L
E
E
H
P
E
V
F
E
Y
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
60.05
41%
-100
- C2 -
1DV1
1
ACCC_ECOLI
A:
[2-444]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
GD
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
-------
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
-----
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
59.58
42%
-93
- C2 -
2C00
1
ACCC_PSEAE
A:
[5-444]
-------
V
L
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
T
A
D
R
E
L
M
H
L
S
L
A
D
E
S
V
---
C
I
G
P
A
P
-
A
---
T
Q
S
Y
L
Q
I
P
A
I
I
A
A
A
E
V
T
G
A
T
A
I
H
P
G
Y
G
F
L
A
E
N
A
D
F
A
E
Q
I
E
R
S
G
F
T
F
V
G
P
T
A
E
V
I
R
L
M
G
D
K
V
S
A
K
D
A
M
K
R
A
G
V
P
T
V
P
G
S
--
D
G
-
P
--
L
--
P
-
E
D
E
E
T
A
L
A
I
A
R
E
V
G
Y
P
V
I
I
K
A
A
G
---
G
R
G
M
R
V
V
Y
D
E
S
E
L
I
K
S
A
K
L
T
R
T
E
A
G
--
F
G
N
P
M
V
Y
L
E
K
F
L
T
N
P
R
H
V
E
V
Q
V
L
S
D
G
Q
G
N
A
I
H
---
L
G
D
R
D
C
S
L
Q
R
R
H
Q
K
V
I
E
E
A
P
A
P
G
I
D
E
K
A
R
Q
E
V
F
A
R
C
V
Q
A
C
I
E
---
I
G
Y
R
G
A
G
T
F
E
F
L
Y
E
N
---
G
R
F
Y
F
I
E
M
N
T
R
V
Q
V
E
H
P
V
S
E
M
V
T
G
V
D
I
V
K
E
M
L
R
I
A
S
G
E
----
K
L
S
I
------
R
Q
------------
E
D
V
V
----
I
R
G
H
A
L
E
C
R
I
N
A
E
D
---
P
K
T
F
M
P
S
P
G
K
V
K
H
F
H
A
P
-
G
-
G
N
G
V
R
V
D
-
S
H
-
L
Y
S
G
Y
S
V
P
P
N
Y
D
S
L
V
G
K
V
I
T
--
Y
G
A
D
R
D
E
A
L
A
R
M
R
N
A
L
D
E
L
I
V
D
G
I
K
T
N
T
E
L
H
K
D
L
V
R
D
A
A
F
C
K
G
G
V
N
I
H
Y
L
E
K
K
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
59.55
43%
-114
- C2 -
4QSH
1
?
D:
[2-462]
M
M
N
R
I
K
K
V
L
V
A
N
R
G
E
I
A
I
R
V
M
R
A
C
T
E
L
K
I
K
T
V
A
I
Y
S
Q
E
D
T
G
S
F
H
R
Y
K
S
D
E
A
Y
----
L
V
-
G
A
-
G
KKP
I
D
A
Y
L
D
I
E
N
I
I
E
I
A
K
E
S
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
I
E
F
A
R
R
C
E
Q
E
G
I
I
F
V
G
P
K
S
K
H
L
D
M
F
G
D
K
I
K
A
K
E
Q
A
L
L
A
D
I
P
V
I
P
------------------------------------------------------------------------------
C
V
M
N
P
K
H
I
E
V
Q
I
L
G
D
T
H
G
N
I
V
H
---
L
F
E
R
D
C
S
I
Q
R
R
H
Q
K
V
V
E
V
A
P
C
N
A
I
T
S
E
L
R
N
R
I
C
D
A
A
V
K
L
M
K
N
---
V
D
Y
I
N
A
G
T
V
E
F
L
V
E
G
D
---
D
F
Y
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
I
T
G
I
D
I
V
Q
S
Q
L
F
I
A
D
G
Y
ALHD
Q
L
V
A
I
P
----
K
Q
------------
E
D
I
H
----
I
H
G
S
A
I
Q
S
R
I
T
T
E
D
P
L
--
N
N
F
M
P
D
T
G
R
V
D
T
Y
R
S
T
-
G
-
G
F
G
V
R
L
D
A
G
N
-
G
F
Q
G
T
V
V
T
P
F
Y
D
S
L
L
V
K
L
C
T
--
W
G
M
T
F
E
Q
A
T
R
K
M
R
R
N
L
I
E
F
R
I
R
G
V
K
T
N
I
P
F
L
L
N
V
V
R
H
P
D
F
A
S
G
N
Y
N
T
S
F
I
D
T
T
P
E
L
F
K
F
P
H
I
R
D
R
----------------------
G
-----
T
--------
K
------
T
----
L
------------
R
---------------------
Y
--------
I
---------
G
-------------
N
V
-------
T
----------
V
N
--------------------
G
-----------------
F
P
G
I
K
H
R
D
K
P
V
Y
A
E
P
R
L
P
K
I
P
Y
G
S
Q
I
-
S
P
G
T
K
Q
I
L
D
A
K
G
P
E
G
V
V
D
W
V
K
K
Q
E
E
V
L
L
T
D
T
T
L
R
D
A
H
Q
S
L
L
A
T
R
V
R
S
K
D
I
F
Q
I
A
D
A
M
A
H
L
L
P
N
M
F
S
F
E
M
W
G
G
A
T
F
D
V
A
Y
R
F
L
N
E
D
P
W
V
R
L
E
T
L
R
K
Q
I
P
N
V
M
F
Q
M
L
L
R
G
A
N
A
V
G
Y
K
N
Y
P
D
N
V
I
R
E
F
V
K
Q
S
A
Q
S
G
V
D
V
F
R
V
F
D
S
L
N
W
I
K
G
M
E
V
S
I
D
A
V
R
E
A
G
K
I
V
E
A
A
I
C
Y
T
G
D
I
D
D
D
T
R
T
K
Y
T
I
D
Y
Y
K
D
M
A
K
E
L
V
A
Q
G
T
H
I
L
G
I
K
D
M
A
G
L
L
K
P
Q
A
A
Y
R
L
I
G
E
L
K
D
T
V
D
V
P
I
H
L
H
T
H
D
T
S
G
N
G
I
Y
T
Y
A
A
A
V
S
A
G
V
D
I
V
D
V
A
S
S
A
M
S
G
A
T
S
Q
P
S
M
T
G
L
Y
Y
G
L
V
N
G
N
R
Q
T
N
L
D
A
Q
N
S
Q
I
I
N
H
Y
W
E
D
V
R
H
Y
Y
K
D
F
D
N
A
L
N
S
P
Q
T
E
V
Y
I
H
E
M
P
G
G
Q
Y
T
N
L
Q
Q
Q
A
I
A
V
G
L
G
D
R
W
D
E
V
K
E
M
Y
T
V
V
N
Q
M
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
L
A
L
F
M
V
Q
N
E
L
S
E
E
D
V
Y
E
K
G
D
T
I
D
F
P
D
S
V
I
E
F
F
M
G
E
I
G
Q
P
Y
G
G
F
P
E
K
L
Q
K
L
V
L
K
G
R
T
P
L
T
D
R
P
G
A
L
M
E
P
V
N
F
V
E
V
K
A
E
L
K
E
K
M
G
Y
E
P
T
E
K
D
V
I
S
Y
I
L
Y
P
K
V
F
L
D
Y
Q
E
M
I
N
K
Y
G
D
V
T
V
L
D
T
P
T
F
Y
K
G
M
R
L
G
E
T
I
E
V
E
L
E
K
G
K
I
L
L
I
K
L
N
S
I
G
E
P
I
A
D
G
T
R
V
I
Y
F
E
L
N
G
Q
P
R
E
I
N
I
Q
D
M
N
V
A
R
R
K
I
D
T
T
N
P
E
H
V
G
A
T
M
T
G
S
V
I
Q
V
V
V
K
K
G
D
S
V
K
K
G
15
PsiBlast_PDB
59.54
42%
-94
- C2 -
1ULZ
-
?
A:
[3-447]
-----
N
K
V
L
V
A
N
R
G
E
I
A
V
R
I
I
R
A
C
K
E
L
G
I
P
T
V
A
I
Y
N
E
V
E
S
T
A
R
H
V
K
L
A
D
E
A
Y
---
M
I
G
-
T
D
-
P
---
L
D
T
Y
L
N
K
Q
R
I
I
N
L
A
L
E
V
G
A
D
A
I
H
P
G
Y
G
F
L
A
E
N
A
E
F
A
K
M
C
E
E
A
G
I
T
F
I
G
P
H
W
K
V
I
E
L
M
G
D
K
A
R
S
K
E
V
M
K
K
A
G
V
P
V
V
P
G
S
--
D
G
-
V
--
L
K-
S
-
L
E
E
A
K
A
L
A
R
E
I
--
G
Y
P
V
L
L
K
A
T
A
G
G
G
G
R
G
I
R
I
C
R
N
E
E
E
L
V
K
N
Y
E
Q
A
S
R
E
A
E
K
A
F
G
R
G
D
L
L
L
E
K
F
I
E
N
P
K
H
I
E
Y
Q
V
L
G
D
K
H
G
N
V
I
H
---
L
G
E
R
D
C
S
I
Q
R
R
N
Q
K
L
V
E
I
A
P
S
L
I
L
T
P
E
K
R
E
Y
Y
G
N
I
V
T
K
A
A
K
E
---
I
G
Y
Y
N
A
G
T
M
E
F
I
A
D
Q
E
--
G
N
L
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
S
E
M
V
T
G
I
D
I
V
K
W
Q
I
K
I
A
A
G
E
----
P
L
T
I
------
K
Q
------------
E
D
V
K
----
F
N
G
Y
A
I
E
C
R
I
N
A
E
D
P
K
K
N
F
A
--
P
S
T
R
V
I
E
R
Y
Y
V
P
-
G
-
G
F
G
I
R
V
E
-
H
A
-
A
A
R
G
F
E
V
T
P
Y
Y
D
S
M
I
A
K
L
I
T
--
W
A
P
T
W
D
E
A
V
E
R
M
R
A
A
L
E
T
Y
E
I
T
G
V
K
T
T
I
P
L
L
I
N
I
M
K
E
K
D
F
K
A
G
K
F
T
T
K
Y
L
E
E
H
P
E
V
F
E
Y
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
59.50
41%
-95
- C2 -
2W6N
2
ACCC_ECOLI
B:
[2-444]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
GD
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
59.45
41%
-95
- C2 -
2W71
2
ACCC_ECOLI
A:
[2-444]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
G
D
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
59.43
41%
-97
- C2 -
2W6O
2
ACCC_ECOLI
A:
[2-444]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
G
D
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
59.36
40%
-96
- C2 -
3G8D
1
ACCC_ECOLI
A:
[2-444]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
-------------------------------------------------------------------------------
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
A
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
59.23
41%
-95
- C2 -
2W6O
2
ACCC_ECOLI
C:
[2-444]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
GD
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
59.17
41%
-99
- C2 -
4HR7
4
ACCC_ECOLI
E:
[2-444]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
G
D
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
----------
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
-------------
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
59.16
41%
-95
- C2 -
2W6Z
2
ACCC_ECOLI
A:
[2-444]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
G
D
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
59.15
41%
-95
- C2 -
2V5A
2
ACCC_ECOLI
A:
[2-444]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
G
D
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
59.10
41%
-94
- C2 -
3JZF
1
ACCC_ECOLI
B:
[23-465]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
G
D
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
59.07
41%
-92
- C2 -
3RUP
6
ACCC_ECOLI
B:
[5-447]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
GD
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
59.06
40%
-92
- C2 -
3RV4
10
ACCC_ECOLI
A:
[5-447]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
E
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
G
D
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
58.93
40%
-95
- C2 -
3G8D
3
ACCC_ECOLI
B:
[2-444]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
G
D
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
A
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147
HHSearch
58.76
38%
-92
- C2 -
3OUZ
15
?
A:
[2-446]
N
A
M
E
I
K
S
I
L
I
A
N
R
G
E
I
A
L
R
A
L
R
T
I
K
E
M
G
K
K
A
I
C
V
Y
S
E
A
D
K
D
A
L
Y
L
K
Y
A
D
A
S
I
---
C
I
G
-
K
A
-
R
S--
S
E
S
Y
L
N
I
P
A
I
I
A
A
A
E
I
A
E
A
D
A
I
F
P
G
Y
G
F
L
S
E
N
Q
N
F
V
E
I
C
A
K
H
N
I
K
F
I
G
P
S
V
E
A
M
N
L
M
S
D
K
S
K
A
K
Q
V
M
Q
R
A
G
V
P
V
I
P
G
S
--
D
G
A
L
--
A
--
G
-
A
E
A
A
K
K
L
A
K
E
I
--
G
Y
P
V
I
L
K
A
A
A
G
G
G
G
R
G
M
R
V
V
E
N
E
K
D
L
E
K
A
Y
W
S
A
E
S
E
A
M
T
A
F
G
D
G
T
M
Y
M
E
K
Y
I
Q
N
P
R
H
I
E
V
Q
V
I
G
D
S
F
G
N
V
I
H
---
V
G
E
R
D
C
S
M
Q
R
R
H
Q
K
L
I
E
E
S
P
A
I
L
L
D
E
K
T
R
T
R
L
H
E
T
A
I
K
A
A
K
A
---
I
G
Y
E
G
A
G
T
F
E
F
L
V
D
K
N
--
L
D
F
Y
F
I
E
M
N
T
R
L
Q
V
E
H
C
V
S
E
M
V
S
G
I
D
I
I
E
Q
M
I
K
V
A
E
G
Y
----
A
L
P
S
Q
E
----
S
---------------
I
K
----
L
N
G
H
S
I
E
C
R
I
T
A
E
D
S
K
---
T
F
L
P
S
P
G
K
I
T
K
Y
I
P
P
-
A
-
G
R
N
V
R
M
E
-
S
H
-
C
Y
Q
D
Y
S
V
P
A
Y
Y
D
S
M
I
G
K
L
V
V
--
W
A
E
D
R
N
K
A
I
A
K
M
K
V
A
L
D
E
L
L
I
S
G
I
K
T
T
K
D
F
H
L
S
M
M
E
N
P
D
F
I
N
N
N
Y
D
T
N
Y
L
A
R
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
58.75
41%
-94
- C2 -
3JZI
1
ACCC_ECOLI
B:
[23-465]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
G
D
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
58.75
41%
-97
- C2 -
2VR1
2
ACCC_ECOLI
A:
[2-444]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
G
D
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
--
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
58.68
41%
-95
- C2 -
2W6Q
2
ACCC_ECOLI
A:
[2-444]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
G
D
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
58.62
41%
-95
- C2 -
2W70
2
ACCC_ECOLI
A:
[2-444]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
G
D
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
58.54
41%
-91
- C2 -
3RUP
5
ACCC_ECOLI
A:
[5-447]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
G
D
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
58.49
41%
-95
- C2 -
2W6Q
2
ACCC_ECOLI
B:
[2-444]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
GD
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
HHSearch
58.41
41%
-86
- C2 -
2VPQ
4
?
A:
[2-446]
-----
K
K
V
L
I
A
N
R
G
E
I
A
V
R
I
I
R
A
C
R
D
L
G
I
Q
T
V
A
I
Y
S
E
G
D
K
D
A
L
H
T
Q
I
A
D
E
A
Y
---
C
V
G
-
P
T
L
S
---
K
D
S
Y
L
N
I
P
N
I
L
S
I
A
T
S
T
G
C
D
G
V
H
P
G
Y
G
F
L
A
E
N
A
D
F
A
E
L
C
E
A
C
Q
L
K
F
I
G
P
S
Y
Q
S
I
Q
K
M
G
I
K
D
V
A
K
A
E
M
I
K
A
N
V
P
V
V
P
G
S
DG
L
--
M
--
K
--
D
-
V
S
E
A
K
K
I
A
K
K
I
--
G
Y
P
V
I
I
K
A
T
A
G
G
G
G
K
G
I
R
V
A
R
D
E
K
E
L
E
T
G
F
R
M
T
E
Q
E
A
Q
T
A
F
G
N
G
G
L
Y
M
E
K
F
I
E
N
F
R
H
I
E
I
Q
I
V
G
D
S
Y
G
N
V
I
H
---
L
G
E
R
D
C
T
I
Q
R
R
M
Q
K
L
V
E
E
A
P
S
P
I
L
D
D
E
T
R
R
E
M
G
N
A
A
V
R
A
A
K
A
---
V
N
Y
E
N
A
G
T
I
E
F
I
Y
D
L
N
-
D
N
K
F
Y
F
M
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
V
T
G
I
D
L
V
K
L
Q
L
Q
V
A
M
G
D
----
V
L
P
Y
K
Q
----
E
--------------
D
I
K
----
L
T
G
H
A
I
E
F
R
I
N
A
E
N
P
Y
K
N
--
F
M
P
S
P
G
K
I
E
Q
Y
L
A
P
-
G
-
G
Y
G
V
R
I
E
-
S
A
-
C
Y
T
N
Y
T
I
P
P
Y
Y
D
S
M
V
A
K
L
I
I
--
H
E
P
T
R
D
E
A
I
M
A
G
I
R
A
L
S
E
F
V
V
L
G
I
D
T
T
I
P
F
H
I
K
L
L
N
N
D
I
F
R
S
G
K
F
N
T
N
F
L
E
Q
N
S
I
M
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
58.33
41%
-94
- C2 -
3G8C
4
ACCC_ECOLI
B:
[2-444]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
GD
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
58.20
41%
-94
- C2 -
2V59
1
ACCC_ECOLI
B:
[2-444]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
GD
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
58.18
41%
-94
- C2 -
2W70
2
ACCC_ECOLI
B:
[2-444]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
GD
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
58.17
42%
-84
- C2 -
2VQD
3
ACCC_PSEAE
A:
[5-444]
-------
V
L
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
T
A
D
R
E
L
M
H
L
S
L
A
D
E
S
V
---
C
I
G
P
A
P
-
A
---
T
Q
S
Y
L
Q
I
P
A
I
I
A
A
A
E
V
T
G
A
T
A
I
H
P
G
Y
G
F
L
A
E
N
A
D
F
A
E
Q
I
E
R
S
G
F
T
F
V
G
P
T
A
E
V
I
R
L
M
G
D
K
V
S
A
K
D
A
M
K
R
A
G
V
P
T
V
P
G
S
--
D
G
-
P
--
L
--
P
-
E
D
E
E
T
A
L
A
I
A
R
E
V
G
Y
P
V
I
I
K
A
A
G
G
G
G
G
R
G
M
R
V
V
Y
D
E
S
E
L
I
K
S
A
K
L
T
R
T
E
A
G
A
A
F
G
N
P
M
V
Y
L
E
K
F
L
T
N
P
R
H
V
E
V
Q
V
L
S
D
G
Q
G
N
A
I
H
---
L
G
D
R
D
C
S
L
Q
R
R
H
Q
K
V
I
E
E
A
P
A
P
G
I
D
E
K
A
R
Q
E
V
F
A
R
C
V
Q
A
C
I
E
---
I
G
Y
R
G
A
G
T
F
E
F
L
Y
E
N
---
G
R
F
Y
F
I
E
M
N
T
R
V
Q
V
E
H
P
V
S
E
M
V
T
G
V
D
I
V
K
E
M
L
R
I
A
S
G
E
----
K
L
S
I
------
R
Q
------------
E
D
V
V
----
I
R
G
H
A
L
E
C
R
I
N
A
E
D
---
P
K
T
F
M
P
S
P
G
K
V
K
H
F
H
A
P
-
G
-
G
N
G
V
R
V
D
-
S
H
-
L
Y
S
G
Y
S
V
P
P
N
Y
D
S
L
V
G
K
V
I
T
--
Y
G
A
D
R
D
E
A
L
A
R
M
R
N
A
L
D
E
L
I
V
D
G
I
K
T
N
T
E
L
H
K
D
L
V
R
D
A
A
F
C
K
G
G
V
N
I
H
Y
L
E
K
K
L
G
M
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
58.16
40%
-88
- C2 -
2VPQ
4
?
A:
[4-444]
-------
V
L
I
A
N
R
G
E
I
A
V
R
I
I
R
A
C
R
D
L
G
I
Q
T
V
A
I
Y
S
E
G
D
K
D
A
L
H
T
Q
I
A
D
E
A
Y
C
VG
P
T
L
-
S
K
-
D
-----
S
Y
L
N
I
P
N
I
L
S
I
A
T
S
T
G
C
D
G
V
H
P
G
Y
G
F
L
A
E
N
A
D
F
A
E
L
C
E
A
C
Q
L
K
F
I
G
P
S
Y
Q
S
I
Q
K
M
G
I
K
D
V
A
K
A
E
M
I
K
A
N
V
P
V
V
P
G
S
--
D
G
-
L
--
M
--
K
D
V
S
E
A
K
K
I
A
K
K
I
G
--
Y
P
V
I
I
K
A
T
A
G
G
G
G
K
G
I
R
V
A
R
D
E
K
E
L
E
T
G
F
R
M
T
E
Q
E
A
Q
T
A
F
G
N
G
G
L
Y
M
E
K
F
I
E
N
F
R
H
I
E
I
Q
I
V
G
D
S
Y
G
N
V
I
H
---
L
G
E
R
D
C
T
I
Q
R
R
M
Q
K
L
V
E
E
A
P
S
P
I
L
D
D
E
T
R
R
E
M
G
N
A
A
V
R
A
A
K
A
---
V
N
Y
E
N
A
G
T
I
E
F
I
Y
-
D
L
N
D
N
K
F
Y
F
M
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
V
T
G
I
D
L
V
K
L
Q
L
Q
V
A
M
G
D
----
V
L
P
Y
------
K
Q
------------
E
D
I
K
----
L
T
G
H
A
I
E
F
R
I
N
A
E
N
P
Y
K
N
--
F
M
P
S
P
G
K
I
E
Q
Y
L
A
P
-
G
-
G
Y
G
V
R
I
E
-
S
A
-
C
Y
T
N
Y
T
I
P
P
Y
Y
D
S
M
V
A
K
L
I
I
--
H
E
P
T
R
D
E
A
I
M
A
G
I
R
A
L
S
E
F
V
V
L
G
I
D
T
T
I
P
F
H
I
K
L
L
N
N
D
I
F
R
S
G
K
F
N
T
N
F
L
E
Q
N
S
I
M
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
58.13
41%
-95
- C2 -
2W6N
2
ACCC_ECOLI
A:
[2-444]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
G
D
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
58.11
41%
-92
- C2 -
3G8C
4
ACCC_ECOLI
A:
[2-444]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
G
D
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
58.06
41%
-94
- C2 -
2V59
1
ACCC_ECOLI
A:
[2-444]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
G
D
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
57.98
41%
-94
- C2 -
2V58
2
ACCC_ECOLI
A:
[2-444]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
G
D
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
57.90
41%
-96
- C2 -
2W71
2
ACCC_ECOLI
C:
[2-444]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
GD
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
57.81
41%
-94
- C2 -
2V58
2
ACCC_ECOLI
B:
[2-444]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
GD
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
57.69
41%
-94
- C2 -
2J9G
3
ACCC_ECOLI
A:
[2-444]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
G
D
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
--
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
57.53
41%
-94
- C2 -
2W6P
1
ACCC_ECOLI
A:
[2-444]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
G
D
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
57.51
41%
-93
- C2 -
3RV3
3
ACCC_ECOLI
A:
[5-447]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
G
D
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
57.39
41%
-93
- C2 -
3JZI
1
ACCC_ECOLI
A:
[23-465]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
G
D
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
57.38
41%
-93
- C2 -
3RV3
3
ACCC_ECOLI
B:
[5-447]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
GD
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
57.23
40%
-91
- C2 -
1DV2
1
ACCC_ECOLI
A:
[5-447]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
GD
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
K
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
56.81
40%
-93
- C2 -
1DV2
1
ACCC_ECOLI
B:
[5-447]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
GD
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
K
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
56.28
41%
-96
- C2 -
2J9G
3
ACCC_ECOLI
B:
[2-444]
----
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
---
C
I
G
P
A
P
-
S
---
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
--
L
G
D
D
-
M
D
K
N
R
A
I
A
K
R
I
G
--
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
--
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
---
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
---
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
----
P
L
S
I
K
Q
----
E
E
--------------
V
H
----
V
R
G
H
A
V
E
C
R
I
N
A
E
D
---
P
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
-
G
-
G
F
G
V
R
W
E
-
S
H
-
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
--
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
55.82
41%
-87
- C2 -
4RZQ
2
ACCC_HAEIN
A:
[25-464]
-------
V
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
T
A
D
R
D
L
K
H
V
L
L
A
D
E
T
I
---
C
I
G
P
A
P
-
S
---
A
K
S
Y
L
N
I
P
A
I
I
A
A
A
E
V
T
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
A
D
F
A
E
Q
V
E
R
S
G
F
T
F
I
G
P
T
A
D
V
I
R
L
M
G
D
K
V
S
A
I
K
A
M
K
K
A
G
V
P
C
V
P
G
S
--
D
G
-
P
----------
A
K
N
K
E
I
A
K
R
I
G
Y
P
I
I
I
K
----------
R
V
V
R
S
E
D
A
L
E
E
S
I
A
M
T
K
A
E
----------
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
T
H
G
N
A
V
Y
---
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
E
E
V
R
R
---
D
I
G
S
R
C
A
N
A
C
V
E
I
G
Y
R
G
A
G
T
F
E
F
L
Y
E
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
V
K
E
Q
L
R
I
A
A
G
L
----
P
I
S
F
------
K
Q
------------
E
D
I
K
----
V
K
G
H
A
M
E
C
R
I
N
A
E
D
---
P
K
T
F
L
P
S
P
G
K
V
N
H
L
H
S
P
-
G
-
G
L
G
V
R
W
D
-
S
H
-
V
Y
G
G
Y
T
V
P
P
H
Y
D
S
M
I
A
K
L
I
T
--
Y
G
D
T
R
E
V
A
I
R
R
M
Q
N
A
L
S
E
T
I
I
D
G
I
K
T
N
I
P
L
H
E
L
I
L
E
D
E
N
F
Q
K
G
G
T
N
I
H
Y
L
E
K
K
L
G
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------