@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA1429: (2016-01-29 )
MNGIPPLSSRDAHASPPQRVLERLHSSAAGLDADEAARRLAAHGYNRLPAPKRQGPLLRLLRQFHNVLLYMMLFASLVTALLGFWVDSAVILLAVVVNALIGFVQEGKAANALDAIRDMLSLHALVLRDGQRQALDAERLVPGDVVLLASGDRVPADLRLFETKNFHVDESALTGESVPVEKGCVAVAIDALLGDRRCMAYSGTLVTSGQARGVVVATAGDTELGRIGTLLREVRTLATPLLRQIASFSRWLALAILLLAGATFVLGTLWQGQPMVDMFMLVVALTASAIPEGLPAIMTVILALGVQRMARRNAIVSRLPAVETLGSVTVICSDKTGTLTRNEMTVQRIVTADQVIEVSGAGYAPLGGFSHNGEGLDPAGRDDLQEIGRAALLCNEARLHQEGEAWQLEGDPTEGALLSLGLKLGLDPQALAAERPRSDAIPFESEHRFMATLHHDHAGQAMVYLKGAPERILDMCEAERVGDSVRPLDPDYWRRLATDTAARGLRLLAIARRAMPAEQRTLDFADVEHGFTLLALVGIIDPPREEAVAAVAECQAAGIAVKMITGDHVDTARAIGAMLGIGIDRPALTGAEIELLDDQRLREVLPGVDVFARASPEHKLRLVQALQASGEVVAMTGDGVNDAPALKRADVGVAMGNKGTEAAKEAAEVVLADDNFATIANAVREGRAVYDNLKKFILFMLPTNGGEALIVIAAILFQLTLPMTPAQILWINMVTSSTLGLALAFDPAERGLMQRPPRPPAEPLLSLFFVWRVLLVSLLMMAGALGLFLWELEHGTGLESARTMAVNSVVVCEMFYLLNSRHIYDSVLSREGLFGNRQVLLAIAACVMLQLLYTYAPPLQALFGSVGLAPGEWARVLLAGLGLFCVAELEKWLCRRVRARQA
Atome Classification :
(43 SA)
.........10........20....-....-30........40........50........60........70........80...----------.----------....90........100.......110.......120.......130--.......140.......150.......160..--.--....170.......180.......-190........200.......210.......220.......230.......240.......250.......260.......270...---------....280.......290.......300.......310.......320.......330.......340.......350...---------....360.......370.......380.......390.......--400..--.....410.......420......----------------.430---....------------....440.......450----.........460----..----......470.......480.......490......-----.500..-----.....510.....--..520----...----......530.......540.......550.......560.......570.......580----.------.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770....-------------...---------------------780--------.......790-------------------------------.---......800------.----------.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNGIPPLSSRDAHAS
P
P
Q
R
V
L
E
R
L
H
-
S
SAA-GL
D
A
D
E
A
A
R
R
L
A
AHGYNRLPAPKRQ
G
P
L
L
R
L
L
R
Q
F
H
N
V
L
L
Y
M
M
L
F
A
S
L
V
T
A
L
L
G
F
----------
W
----------
V
D
S
A
V
I
L
L
A
V
V
V
N
A
L
I
G
F
V
QEGKAA
N
A
L
D
A
I
R
D
M
L
S
L
H
A
L
V
LRDGQR--QAL
D
A
E
RLVPG
D
V
V
L
L
ASGDRVPA
D
L
R
L
F
E
TK--N--FHVDESALTGESVPVEKG
C
V
A
V
A
I
-
D
-
A
L
LGDR
R
C
M
A
YS
G
T
L
V
TSGQA
R
G
V
V
V
A
TAGDT
E
L
G
R
I
G
T
L
L
R
E
V
R
T
L
A
T
P
L
L
R
Q
I
A
S
F
S
R
W
L
A
L
A
I
L
L
LA
G
A
T
F
V
L
G
T
LWQG
Q
P
M
---------
V
D
M
F
M
L
V
V
A
L
T
A
S
AIPE
G
L
P
A
I
M
T
V
I
L
A
L
G
V
Q
R
M
A
R
R
N
A
I
V
S
RLP
A
V
ETLG
S
V
T
V
I
CSDKTG
T
L
TRN
E
M
T
V
Q
R
IVTAD
Q
V
---------
I
E
VSGAGYAPLGGFSHNGEGLDPA
G
R
D
D
L
Q
E
I
G
R
A
A
L
L
C
N
E
A
R
L--HQEG
E
--
A
W
Q
LEGDPTE
G
A
L
L
S
L
G
L
KLGL
D
P
----------------
Q
A
L
----AAER------------PRSDAIPFESEH
R
F
M
------
A
T
LHHDHAG
Q
A
-----
M
V
----
Y
LKGA
P
E
R
I
L
D
M
C
E
A
E
RVGDSVRPL
D
P
D
Y
W
R
R
L
A
T
-----
D
T
A
AR
G
-----
L
R
L
L
A
I
A
R
RAMPA--EQR------TL
D
----
F
A
D
V
EH
G
F
T
L
L
A
L
V
GIIDP
P
R
E
E
A
V
A
A
V
A
E
CQAA
G
I
A
V
K
M
ITGDHV
D
T
A
R
A
I
G
A
M
L
GI-----G------IDRPALTGA
E
I
E
LL
D
D
Q
R
L
R
E
VLPG
V
D
V
FARAS
P
E
H
K
L
R
L
V
Q
A
L
Q
ASG
E
V
V
A
M
TGDGVNDAPALKRADV
G
V
AMGNK
G
T
E
A
A
K
E
A
A
E
V
V
LADD
N
F
A
T
I
A
N
A
V
RE
G
R
A
V
Y
D
N
L
K
K
F
I
L
F
M
L
PTNGG
E
A
L
I
V
I
A
A
I
L
F
Q
LTLPMTP
A
Q
I
L
W
I
N
MVTSST
L
G
L
A
L
A
F
D
P
A
ERGLMQRPPRP
P
A
E
P
L
L
S
L
F
F
V
W
R
V
L
L
V
-------------
S
L
L
---------------------
M
M
A
--------
G
A
L
G
L
F
L
W
E
L-------------------------------E---HGTGLE
S
A
-------
R
----------
T
M
A
V
N
S
V
V
V
C
E
M
F
Y
L
LNS
R
H
I
Y
D
S
V
L
SREGLFG
N
R
Q
V
L
L
A
I
A
A
C
V
M
L
Q
L
L
Y
TYA
P
P
L
Q
A
L
F
G
SVGLA
P
G
E
W
A
R
V
L
L
A
G
L
G
L
F
C
V
A
E
L
E
K
W
L
C
R
R
V
RARQA
122
Fugue
91.65
36%
-106
- C1 -
1SU4
3
AT2A1_RABIT
A:
[1-994]
M
E
A
--------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
-
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
EEGEETITA
F
----------
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
ST
T
--
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
-
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGSWI
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
--
D
F
N
E
T
KG
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
TEVRNLSKVERAN
A
C
N
S
V
I
----
R
Q
L
M
------------
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
------
S
V
Y
C
S
P
A
K
S
S
R
AAVG
N
K
M
----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
-----
V
I
K
E
W
G
T
GRDT
L
R
C
L
A
L
A
T
R
D
T
P
P
--
K
R
E
EMVLDD
S
S
R
----
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
FGENE
E
------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
-------------
G
G
Y
---------------------
V
G
A
--------
A
T
V
G
A
A
A
W
W
F
MYAEDGPGVTYHQLTHFMQCTEDHPHFEGLD
C
---
E
I
F
E
A
P
E
P
-------
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
-
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
66
PsiBlast_CBE
91.37
33%
-94
- C1 -
4BEW
8
AT2A1_RABIT
A:
[4-990]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETITAF
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGSW
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
AN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVT
Y
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEA
P
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
D
--
35
PsiBlast_CBE
91.02
33%
-95
- C1 -
3N5K
6
AT2A1_RABIT
A:
[4-990]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETITAF
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGSWI
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
AN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVT
Y
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEA
P
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
16
PsiBlast_PDB
90.94
33%
-97
- C1 -
2O9J
4
AT2A1_RABIT
A:
[4-990]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETITAF
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
--------RGA------
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
AN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEA
P
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
21
PsiBlast_CBE
90.90
33%
-100
- C1 -
4YCL
3
AT2A1_RABIT
A:
[5-991]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETITAF
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVT
Y
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEA
P
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
54
PsiBlast_CBE
90.86
33%
-100
- C1 -
2YFY
3
?
A:
[4-990]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETITAF
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEAP
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
60
PsiBlast_CBE
90.77
33%
-96
- C1 -
1WPG
6
AT2A1_RABIT
D:
[4-990]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETITAF
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
SV
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
TT
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGSWIRGA
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGDFCSLNE
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
DF
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
ANACNSVIRQLM
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
SVYCSP
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
VIKEW
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
GGYVGAATVGAAA
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEAPEP
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
8
PsiBlast_PDB
90.74
33%
-97
- C1 -
1WPG
6
AT2A1_RABIT
A:
[4-990]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETITAF
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGSWIRGA
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
AN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEAP
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
34
PsiBlast_CBE
90.63
33%
-97
- C1 -
3N5K
6
?
B:
[4-990]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETITAF
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
SV
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
TT
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGSWIRGA
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGDFCSLNE
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
DF
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
ANACNSVIRQLM
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
SVYCSP
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
VIKEW
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
GGYVGAATVGAAA
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEAPEP
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
17
PsiBlast_PDB
90.42
33%
-101
- C1 -
2OA0
3
AT2A1_RABIT
A:
[4-990]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
E
E
G
E
E
TITAF
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
SV
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
--------HGGSWI
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
AN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GE
N
E
E
V
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
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E
Y
L
Q
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Y
D
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A
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T
G
D
G
V
N
D
A
P
A
L
K
K
A
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I
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A
M
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S
-
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A
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A
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D
N
F
S
T
I
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A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
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Y
L
I
S
S
N
V
G
E
V
V
C
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F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
------
E
IFEA
P
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
39
PsiBlast_CBE
90.41
33%
-95
- C1 -
3FGO
8
AT2A1_RABIT
A:
[4-990]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETITAF
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGSW
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
AN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVT
Y
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEA
P
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
30
PsiBlast_CBE
90.38
33%
-100
- C1 -
3NAN
4
?
A:
[4-990]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETITAF
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
AN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEAP
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
31
PsiBlast_CBE
90.36
33%
-102
- C1 -
3NAM
4
?
A:
[4-990]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETITAF
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
AN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEA
P
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
32
PsiBlast_CBE
90.34
33%
-99
- C1 -
3NAL
3
?
A:
[4-990]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETITAF
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
SV
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
AN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEA
P
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
65
PsiBlast_CBE
90.27
33%
-97
- C1 -
4BEW
8
?
B:
[4-990]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETITAF
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
SV
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
TT
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGSWIRGA
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGDFCSLNE
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
DF
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
ANACNSVIRQLM
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
SVYCSP
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
VIKEW
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
GGYVGAATVGAAA
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEAPEP
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
D
--
38
PsiBlast_CBE
90.27
33%
-95
- C1 -
3FGO
8
?
B:
[4-990]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETITAF
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
SV
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
TT
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGSWIRGA
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGDFCSLNE
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
DF
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
ANACNSVIRQLM
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
SVYCSP
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
VIKEW
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
GGYVGAATVGAAA
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEAPEP
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
62
PsiBlast_CBE
90.25
33%
-98
- C1 -
1WPG
5
AT2A1_RABIT
B:
[4-990]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETITAF
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
SV
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
TT
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGSWIRGA
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGDFCSLNE
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
DF
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
ANACNSVIRQLM
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
SVYCSP
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
VIKEW
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
GGYVGAATVGAAA
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEAPEP
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
20
PsiBlast_PDB
90.25
33%
-99
- C1 -
2EAU
5
AT2A1_RABIT
A:
[4-990]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETITAF
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
AN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEA
P
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
61
PsiBlast_CBE
90.22
33%
-97
- C1 -
1WPG
5
AT2A1_RABIT
C:
[4-990]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETITAF
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
SV
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
TT
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGSWIRGA
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGDFCSLNE
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
DF
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
ANACNSVIRQLM
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
SVYCSP
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
VIKEW
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
GGYVGAATVGAAA
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEAPEP
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
25
PsiBlast_CBE
90.15
33%
-99
- C1 -
4J2T
3
AT2A1_RABIT
A:
[4-990]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETITAF
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
AN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEAP
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
37
PsiBlast_CBE
90.03
33%
-99
- C1 -
3FPB
6
AT2A1_RABIT
A:
[4-990]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETITAF
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGSW
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
AN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEA
P
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
12
PsiBlast_PDB
89.74
33%
-100
- C1 -
2C88
4
AT2A1_RABIT
A:
[4-990]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETIT
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
AN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEA
P
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
13
PsiBlast_PDB
89.66
33%
-102
- C1 -
2C8K
4
AT2A1_RABIT
A:
[4-990]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETITAF
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGSWI
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
AN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEA
P
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
1
PsiBlast_PDB
89.63
33%
-106
- C1 -
3W5B
6
AT2A1_RABIT
A:
[10-996]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEET
I
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGDF
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
D
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEAP
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
5
PsiBlast_PDB
89.51
33%
-99
- C1 -
1T5S
5
AT2A1_RABIT
A:
[4-990]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETI
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGSWI
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
AN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEAP
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
36
PsiBlast_CBE
89.32
33%
-99
- C1 -
3FPS
4
AT2A1_RABIT
A:
[4-990]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
E
E
G
E
E
TITAF
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
SV
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGDF
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
ANA
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEA
P
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
67
PsiBlast_CBE
89.29
33%
-100
- C1 -
3TLM
5
AT2A1_BOVIN
A:
[4-989]
-----------
A
H
S
K
T
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
L
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETV
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
T
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
I
G
I
V
A
T
T
G
V
G
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
R
I
DGD
L
C
L
L
N
E
F
S
V
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
V
R
S
G
Q
Y
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
I
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
AN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
------
S
V
Y
C
S
P
A
K
S
R
A
-----
A
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSTK
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
FGENE
D
------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
T
H
K
S
K
I
V
E
Y
L
Q
S
F
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
T
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
-------------
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
LYAEDGPH
V
T
Y
--------
S
Q
L
T
H
F
M
K
C
---------------------------------------
D
F
E
G
V
-------
D
CEVFEAP
Q
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
-
L
V
R
M
P
P
W
V
N
I
W
L
V
G
S
I
G
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
Q
A
L
D
L
Y
H
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
V
A
R
N
Y
L
E
---
22
PsiBlast_CBE
89.12
33%
-96
- C1 -
4XOU
5
AT2A1_RABIT
A:
[4-990]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEE
T
I
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGSWI
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
AN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEAP
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
6
PsiBlast_PDB
89.03
33%
-99
- C1 -
1T5T
6
AT2A1_RABIT
A:
[4-990]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETI
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGSWI
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
AN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEAP
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
33
PsiBlast_CBE
88.91
33%
-98
- C1 -
3N8G
5
AT2A1_RABIT
A:
[4-990]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETI
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGSWI
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
AN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEAP
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
11
PsiBlast_PDB
88.39
33%
-98
- C1 -
2BY4
5
AT2A1_RABIT
A:
[4-990]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETITAF
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
AN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEA
P
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
24
PsiBlast_CBE
72.43
33%
-38
- C1 -
4UU0
6
AT2A1_RABIT
A:
[7-991]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
E
EGEETITAF
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
AN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEA
P
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
48
PsiBlast_CBE
72.24
33%
-42
- C1 -
3AR2
6
?
A:
[7-991]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEE
T
I
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGSWI
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
AN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEAP
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
43
PsiBlast_CBE
72.22
33%
-37
- C1 -
3AR7
6
AT2A1_RABIT
A:
[7-991]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEE
T
I
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
AN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GE
N
E
E
V
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEA
P
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
53
PsiBlast_CBE
71.98
33%
-40
- C1 -
2ZBD
7
?
A:
[7-991]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEE
T
I
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
AN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDG
P
G
V
T
Y
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEAP
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
45
PsiBlast_CBE
71.44
33%
-38
- C1 -
3AR5
6
AT2A1_RABIT
A:
[7-991]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETITAF
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
AN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEA
P
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
23
PsiBlast_CBE
70.91
33%
-38
- C1 -
4UU1
9
AT2A1_RABIT
A:
[7-991]
-----------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
----------
F
EEGEETITAF
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
--
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
-
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
HGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
--
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
----------------
T
E
V
RNLS
K
V
E
R
AN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
-----
M
-----
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
-----
L
R
C
L
A
L
A
T
R
D
T
P
P
KR
E
E
M
------
V
L
D
DSSR
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----
F
GENEEV
A
D
R
-
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
---------------------
M
Y
A
EDGPGVTY
H
Q
L
T
H
F
M
Q
C
T
-------------------------------
E
DHP
H
F
E
G
L
D
C
E
IFEA
P
E
P
M
----------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
-
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
--
81
PsiBlast_CBE
42.22
33%
-33
- C1 -
3A1C
2
?
A:
[157-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----
D
------
L
--------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
S
-
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
42.05
33%
-29
- C1 -
3A1E
1
B:
[157-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----
D
------
L
--------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
S
-
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
41.94
33%
-33
- C1 -
3A1D
1
?
A:
[157-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----
D
------
L
--------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
S
-
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
41.53
33%
-32
- C1 -
3A1D
1
?
B:
[157-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----
D
------
L
--------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
S
-
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
41.00
33%
-32
- C1 -
3A1E
1
COPA_ARCFU
A:
[157-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----
D
------
L
--------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
S
-
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
39.42
33%
-33
- C1 -
3A1C
1
?
B:
[157-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----
D
------
L
--------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
S
-
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------