@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA1529: (2016-01-30 )
MTDTQAAAERIAQLRTELDTHNYRYYVLDEPSIPDAEYDRLFRELQALEAEYPQLLTPDSPTQRVSGTPASAFGEVRHEIPMLSLGNAFEEQDLLDFDRRVREGLADLLPGGDLLGGGAEVEYSCEPKLDGLAVSLLYERGQLVRGATRGDGSTGEDITSNVRTIRNVPLKLHGEGWPEILEVRGEVFMSKAGFEALNAKAVETGGKTFANPRNAAAGSLRQLDSKITASRPLEFCAYGFGQVSGTLPDTQVGILEAFRGWGIPISRELRLVKGAQACRDYYDDIGRRRDALAYEIDGVVFKVNRIAFQRELGFRAREPRWAIAHKFPAREELTELLGVEFQVGRTGAVTPVARLKPVQVAGVTVSNATLHNMDEVARLGLRIGDTVVIRRAGDVIPQVMQVVLERRPADAQAIEVPEHCPVCGSAVERTQLVKRSKGKESISEGAIYRCVGRLSCQAQLKQAIIHFVSRRAMDIDGLGDKIVEQLVDRGLVASPADLYTLTYEQVFELEGFAELSTNNLLTAIADSRKPSLARFIFALGIPDVGEETAKLLARSLGSLERIGKALPEVLTYLPDVGAEVAYEIHNFFADEHNRQVIAQLRDAEHGVQLQEEGEVAAEFAACASLAGFIDKLNIPFIAATGAEKLASRFGSLDGIIRADWLDLRQVERLPERAAKSLRDFFDEPANVQRALAIEAQLREFGMHWQSERKAVEGLPLAGQTWVLTGTLEAMSRDVAKDKLEGLGAKVAGSVSAKTHCVVAGPGAGSKLAKANELGVKVLDEDGLLKLFDEHGVAR
Atome Classification :
(30 SA)
.........10..---......20........30........40........50........60........-70-........80........90........100.......110.......120.......130.......140.......150.......160.......170.-..---...--.180--.......190.......200.......210.......220.......230..--.....240--....-.---...250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440...-....450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
D
T
Q
A
A
A
E
R
I
A
Q
---
L
R
T
ELDTHN
Y
R
Y
Y
V
L
DEPSIP
D
A
E
Y
D
R
L
F
R
E
L
Q
A
L
E
AEYPQLLTPDSPTQRVSGT
P
-
A
S
-
A
F
G
E
V
R
H
EI
P
M
L
SLGNAF
E
E
Q
D
L
L
D
F
D
R
R
V
R
E
G
L
A
D
LLPGGDLLGGG
A
E
V
E
Y
SCEPKLD
G
L
A
V
S
L
L
Y
ERG
Q
L
V
R
G
ATRGDGST
G
E
D
I
T
S
N
V
R
T
I
RNV
P
L
K
LH-GE---G
W
P
--
E
I
L
E
--
V
R
G
E
V
F
M
SKAGFEALN
A
K
A
VETGGKTFANPRNAAA
G
S
L
R
Q
L
D
S
KITASR
P
L
E
--
F
C
A
Y
G
F
G
---QVSG-T---LPD
T
Q
V
G
I
L
E
A
F
RGWGIPI
S
R
E
L
R
L
V
K
G
A
Q
A
C
R
D
Y
Y
D
D
I
GRRRD
A
L
A
Y
EID
G
V
V
F
K
V
N
R
I
A
F
Q
R
ELGFRAREP
R
W
A
IAHKFP
A
R
E
E
L
T
E
L
LG
V
E
F
QVGRTGAVTP
V
A
RL
K
P
V
Q
V
A
G
V
T
VSNATLH
N
M
D
E
V
A
R
L
G
LRIG
D
T
V
V
I
RRA
G
D
V
I
P
Q
V
M
Q
V
V
L
ERRPADAQAIEVPEHCPVCG
S
A
V
E
R
T
Q
L
V
K
RSKGKESISE
G
-
A
I
Y
R
C
V
G
R
L
S
C
Q
A
Q
L
K
Q
A
I
I
H
F
V
S
R
RAMDIDG
L
G
D
K
I
V
E
Q
L
V
DRGLVASPA
D
L
Y
T
L
T
Y
E
Q
V
FELEG
F
A
ELSTN
N
L
L
T
A
I
ADSRK
P
S
L
A
R
F
I
F
ALGIPDV
G
E
E
T
A
K
L
L
A
R
S
L
G
S
L
E
R
I
G
K
A
L
P
E
V
L
T
Y
LPDV
G
A
E
V
A
Y
E
I
H
N
F
F
A
DEH
N
R
Q
V
I
A
Q
L
R
DAEHG
V
Q
L
Q
EE
G
E
V
A
A
E
F
A
A
C
A
S
L
A
G
F
I
D
KLNI
P
F
I
AAT
G
A
E
K
L
A
S
R
FGSLD
G
I
I
R
A
D
W
L
D
L
R
Q
V
E
R
L
P
E
R
A
A
K
S
L
R
D
F
FDEP
A
N
V
Q
R
A
L
A
I
E
A
Q
L
R
E
F
G
M
H
W
Q
S
E
R
K
AVEGLPLAG
Q
T
W
V
L
T
G
T
L
E
A
M
S
R
D
V
A
K
D
K
L
E
G
LGAKVAGSVSA
K
T
H
C
V
V
AGPGAGSKLAKANEL
G
V
K
V
LDED
G
L
L
K
L
F
D
EHGVAR
34
HHSearch
89.74
57%
-92
- C4 -
2OWO
8
DNLJ_ECOLI
A:
[2-586]
----
E
S
I
E
Q
Q
L
T
E
---
L
R
T
T
L
R
H
H
E
Y
L
Y
H
V
M
D
A
P
E
I
P
D
A
E
Y
D
R
L
M
R
E
L
R
E
L
E
T
K
H
P
E
L
I
T
P
D
S
P
T
Q
R
V
G
A
A
P
-
L
A
-
A
F
S
Q
I
R
H
E
V
P
M
L
S
L
D
N
V
F
D
E
E
S
F
L
A
F
N
K
R
V
Q
D
R
L
K
N
----------
N
E
K
V
T
W
C
C
E
L
K
L
D
G
L
A
V
S
I
L
Y
E
N
G
V
L
V
S
A
A
T
R
G
D
G
T
T
G
E
D
I
T
S
N
V
R
T
I
R
A
I
P
L
K
L
H
-
G
E
---
N
I
P
--
A
R
L
E
--
V
R
G
E
V
F
L
P
Q
A
G
F
E
K
I
N
E
D
A
R
R
T
G
G
K
V
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
P
R
I
T
A
K
R
P
L
T
--
F
F
C
Y
G
V
G
---
V
L
E
G
-
G
E--
L
P
D
T
H
L
G
R
L
L
Q
F
K
K
W
G
L
P
V
S
D
R
V
T
L
C
E
S
A
E
E
V
L
A
F
Y
H
K
V
E
E
D
R
P
T
L
G
F
D
I
D
G
V
V
I
K
V
N
S
L
A
Q
Q
E
Q
L
G
F
V
A
R
A
P
R
W
A
V
A
F
K
F
P
A
Q
E
Q
M
T
F
V
R
D
V
E
F
Q
V
G
R
T
G
A
I
T
P
V
A
R
L
E
P
V
H
V
A
G
V
L
V
S
N
A
T
L
H
N
A
D
E
I
E
R
L
G
L
R
I
G
D
K
V
V
I
R
R
A
G
D
V
I
P
Q
V
V
N
V
V
L
S
E
R
P
E
D
T
R
E
V
V
F
P
T
H
C
P
V
C
G
S
D
V
E
R
-
V
-----------
E
G
E
-
A
V
A
R
C
T
G
G
L
I
C
G
A
Q
R
K
E
S
L
K
H
F
V
S
R
R
A
M
D
V
D
G
M
G
D
K
I
I
D
Q
L
V
E
K
E
Y
V
H
T
P
A
D
L
F
K
L
T
A
G
K
L
T
G
L
E
R
M
G
P
K
S
A
Q
N
V
V
N
A
L
E
K
A
K
E
T
T
F
A
R
F
L
Y
A
L
G
I
R
E
V
G
E
A
T
A
A
G
L
A
A
Y
F
G
T
L
E
A
L
E
A
A
S
I
E
E
L
Q
K
V
P
D
V
G
I
V
V
A
S
H
V
H
N
F
F
A
E
E
S
N
R
N
V
I
S
E
L
L
A
--
E
G
V
H
W
P
A
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
88.71
55%
-94
- C4 -
2OWO
8
DNLJ_ECOLI
A:
[2-576]
----
E
S
I
E
Q
Q
L
T
E
---
L
R
T
T
L
R
H
H
E
Y
L
Y
H
V
M
D
A
P
E
I
P
D
A
E
Y
D
R
L
M
R
E
L
R
E
L
E
T
K
H
P
E
L
I
T
P
D
S
P
T
Q
R
V
G
A
A
P
-
L
A
-
A
F
S
Q
I
R
H
E
V
P
M
L
S
L
D
N
V
F
D
E
E
S
F
L
A
F
N
K
R
V
Q
----------
D
R
L
K
N
N
E
K
V
T
W
C
C
E
L
K
L
D
G
L
A
V
S
I
L
Y
E
N
G
V
L
V
S
A
A
T
R
G
D
G
T
T
G
E
D
I
T
S
N
V
R
T
I
R
A
I
P
L
K
L
H
-
G
E
---
N
I
P
--
A
R
L
E
--
V
R
G
E
V
F
L
P
Q
A
G
F
E
K
I
N
E
D
A
R
R
T
G
G
K
V
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
P
R
I
T
A
K
R
P
L
T
--
F
F
C
Y
G
V
G
---
V
L
E
G
G
E
---
L
P
D
T
H
L
G
R
L
L
Q
F
K
K
W
G
L
P
V
S
D
R
V
T
L
C
E
S
A
E
E
V
L
A
F
Y
H
K
V
E
E
D
R
P
T
L
G
F
D
I
D
G
V
V
I
K
V
N
S
L
A
Q
Q
E
Q
L
G
F
V
A
R
A
P
R
W
A
V
A
F
K
F
P
A
Q
E
Q
M
T
F
V
R
D
V
E
F
Q
V
G
R
T
G
A
I
T
P
V
A
R
L
E
P
V
H
V
A
G
V
L
V
S
N
A
T
L
H
N
A
D
E
I
E
R
L
G
L
R
I
G
D
K
V
V
I
R
R
A
G
D
V
I
P
Q
V
V
N
V
V
L
S
E
R
P
E
D
T
R
E
V
V
F
P
T
H
C
P
V
C
G
S
D
V
E
R
V
-------------
E
G
E
A
V
A
R
C
T
G
G
L
I
C
G
A
Q
R
K
E
S
L
K
H
F
V
S
R
R
A
M
D
V
D
G
M
G
D
K
I
I
D
Q
L
V
E
K
E
Y
V
H
T
P
A
D
L
F
K
L
T
A
G
K
L
T
G
L
E
R
M
G
P
K
S
A
Q
N
V
V
N
A
L
E
K
A
K
E
T
T
F
A
R
F
L
Y
A
L
G
I
R
E
V
G
E
A
T
A
A
G
L
A
A
Y
F
G
T
L
E
A
L
E
A
A
S
I
E
E
L
Q
K
V
P
D
V
G
I
V
V
A
S
H
V
H
N
F
F
A
E
E
S
N
R
N
V
I
S
E
L
L
A
E
G
V
H
W
P
A
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
88.69
55%
-97
- C4 -
4GLX
5
DNLJ_ECOLI
A:
[3-576]
-----
S
I
E
Q
Q
L
T
E
---
L
R
T
T
L
R
H
H
E
Y
L
Y
H
V
M
D
A
P
E
I
P
D
A
E
Y
D
R
L
M
R
E
L
R
E
L
E
T
K
H
P
E
L
I
T
P
D
S
P
T
Q
R
----
P
-
L
A
-
A
F
S
Q
I
R
H
E
V
P
M
L
S
L
D
N
V
F
D
E
E
S
F
L
A
F
N
K
R
V
Q
----------
D
R
-------
T
W
C
C
E
L
K
L
D
G
L
A
V
S
I
L
Y
E
N
G
V
L
V
S
A
A
T
R
G
D
G
T
T
G
E
D
I
T
S
N
V
R
T
I
R
A
I
P
L
K
L
H
-
G
E
---
N
I
P
--
A
R
L
E
--
V
R
G
E
V
F
L
P
Q
A
G
F
E
K
I
N
E
D
A
R
R
T
G
G
K
V
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
P
R
I
T
A
K
R
P
L
T
--
F
F
C
Y
G
V
G
---
V
L
E
G
G
E
---
L
P
D
T
H
L
G
R
L
L
Q
F
K
K
W
G
L
P
V
S
D
R
V
T
L
C
E
S
A
E
E
V
L
A
F
Y
H
K
V
E
E
D
R
P
T
L
G
F
D
I
D
G
V
V
I
K
V
N
S
L
A
Q
Q
E
Q
L
G
F
V
A
R
A
P
R
W
A
V
A
F
K
F
P
A
Q
E
Q
M
T
F
V
R
D
V
E
F
Q
V
G
R
T
G
A
I
T
P
V
A
R
L
E
P
V
H
V
A
G
V
L
V
S
N
A
T
L
H
N
A
D
E
I
E
R
L
G
L
R
I
G
D
K
V
V
I
R
R
A
G
D
V
I
P
Q
V
V
N
V
V
L
S
E
R
P
E
D
T
R
E
V
V
F
P
T
H
C
P
V
C
G
S
D
V
E
R
V
-------------
E
G
E
A
V
A
R
C
T
G
G
L
I
C
G
A
Q
R
K
E
S
L
K
H
F
V
S
R
R
A
M
D
V
D
G
M
G
D
K
I
I
D
Q
L
V
E
K
E
Y
V
H
T
P
A
D
L
F
K
L
T
A
G
K
L
T
G
L
E
R
M
G
P
K
S
A
Q
N
V
V
N
A
L
E
K
A
K
E
T
T
F
A
R
F
L
Y
A
L
G
I
R
E
V
G
E
A
T
A
A
G
L
A
A
Y
F
G
T
L
E
A
L
E
A
A
S
I
E
E
L
Q
K
V
P
D
V
G
I
V
V
A
S
H
V
H
N
F
F
A
E
E
S
N
R
N
V
I
S
E
L
L
A
E
G
V
H
W
P
A
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
76.02
42%
-77
- C4 -
1DGS
2
DNLJ_THEFI
B:
[4-581]
----
E
E
A
R
R
R
I
N
E
---
L
R
D
L
I
R
Y
H
N
Y
R
Y
Y
V
L
A
D
P
E
I
S
D
A
E
Y
D
R
L
L
R
E
L
K
E
L
E
E
R
F
P
E
F
K
S
P
D
S
P
T
E
Q
V
G
A
R
P
-
L
E
P
T
F
R
P
V
R
H
P
T
R
M
Y
S
L
D
N
A
F
T
Y
E
E
V
L
A
F
E
E
R
L
E
R
E
A
E
------------
A
P
S
L
Y
T
V
E
H
K
V
D
G
L
S
V
-
L
Y
Y
E
E
G
V
W
S
T
G
S
--
G
D
G
E
V
G
E
E
V
T
Q
N
L
L
T
I
P
T
I
P
R
R
L
---
K
---
G
V
P
--
D
R
L
E
--
V
R
G
E
V
Y
M
P
I
E
A
F
L
R
L
N
E
E
L
E
E
R
G
E
K
V
F
K
N
P
R
N
A
A
A
G
S
L
R
Q
K
D
P
R
V
T
A
K
R
G
L
R
AT
F
Y
A
L
G
L
G
LGL
E
E
S
G
-
L
-----
K
S
Q
Y
E
L
L
L
W
L
K
E
K
G
F
P
V
E
H
C
Y
E
K
A
L
G
A
E
G
V
E
E
V
Y
R
R
G
L
A
Q
R
H
A
L
P
F
E
A
D
G
V
V
L
K
L
D
D
L
T
L
W
G
E
L
G
Y
T
A
R
A
P
R
F
A
L
A
Y
K
F
P
A
E
E
K
E
T
R
L
L
D
V
V
F
Q
V
G
R
T
G
R
V
T
P
V
G
V
L
E
P
V
F
I
E
G
S
E
V
S
R
V
T
L
H
N
E
S
Y
I
E
E
L
D
I
R
I
G
D
W
V
L
V
H
K
A
G
G
V
I
P
E
V
L
R
V
L
K
E
R
R
T
G
K
E
R
P
I
R
W
P
E
A
C
P
E
C
G
H
-----
R
L
V
K
---------
E
G
-
K
V
H
R
C
P
N
P
L
-
C
P
A
K
R
F
E
A
I
R
H
Y
A
S
R
K
A
M
D
I
E
G
L
G
E
K
L
I
E
R
L
L
E
K
G
L
V
R
D
V
A
D
L
Y
H
L
R
K
E
D
L
L
G
L
E
R
M
G
E
K
S
A
Q
N
L
L
R
Q
I
E
E
S
K
H
R
G
L
E
R
L
L
Y
A
L
G
L
P
G
V
G
E
V
L
A
R
N
L
A
R
R
F
G
T
M
D
R
L
L
E
A
S
L
E
E
L
I
E
V
E
E
V
G
E
L
T
A
R
A
I
L
E
T
L
K
D
P
A
F
R
D
L
V
R
R
L
K
E
A
--
G
V
S
M
E
S
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
75.77
42%
-76
- C4 -
1DGS
2
DNLJ_THEFI
A:
[4-581]
----
E
E
A
R
R
R
I
N
E
---
L
R
D
L
I
R
Y
H
N
Y
R
Y
Y
V
L
A
D
P
E
I
S
D
A
E
Y
D
R
L
L
R
E
L
K
E
L
E
E
R
F
P
E
F
K
S
P
D
S
P
T
E
Q
V
G
A
R
P
-
L
E
P
T
F
R
P
V
R
H
P
T
R
M
Y
S
L
D
N
A
F
T
Y
E
E
V
L
A
F
E
E
R
L
E
R
E
A
E
------------
A
P
S
L
Y
T
V
E
H
K
V
D
G
L
S
V
-
L
Y
Y
E
E
G
V
W
S
T
G
S
--
G
D
G
E
V
G
E
E
V
T
Q
N
L
L
T
I
P
T
I
P
R
R
L
---
K
---
G
V
P
--
D
R
L
E
--
V
R
G
E
V
Y
M
P
I
E
A
F
L
R
L
N
E
E
L
E
E
R
G
E
K
V
F
K
N
P
R
N
A
A
A
G
S
L
R
Q
K
D
P
R
V
T
A
K
R
G
L
R
A
T
F
Y
A
L
G
L
G
LGL
E
E
S
G
-
L
-----
K
S
Q
Y
E
L
L
L
W
L
K
E
K
G
F
P
V
E
H
C
Y
E
K
A
L
G
A
E
G
V
E
E
V
Y
R
R
G
L
A
Q
R
H
A
L
P
F
E
A
D
G
V
V
L
K
L
D
D
L
T
L
W
G
E
L
G
Y
T
A
R
A
P
R
F
A
L
A
Y
K
F
P
A
E
E
K
E
T
R
L
L
D
V
V
F
Q
V
G
R
T
G
R
V
T
P
V
G
V
L
E
P
V
F
I
E
G
S
E
V
S
R
V
T
L
H
N
E
S
Y
I
E
E
L
D
I
R
I
G
D
W
V
L
V
H
K
A
G
G
V
I
P
E
V
L
R
V
L
K
E
R
R
T
G
K
E
R
P
I
R
W
P
E
A
C
P
E
C
G
H
-----
R
L
V
K
---------
E
G
-
K
V
H
R
C
P
N
P
L
-
C
P
A
K
R
F
E
A
I
R
H
Y
A
S
R
K
A
M
D
I
E
G
L
G
E
K
L
I
E
R
L
L
E
K
G
L
V
R
D
V
A
D
L
Y
H
L
R
K
E
D
L
L
G
L
E
R
M
G
E
K
S
A
Q
N
L
L
R
Q
I
E
E
S
K
H
R
G
L
E
R
L
L
Y
A
L
G
L
P
G
V
G
E
V
L
A
R
N
L
A
R
R
F
G
T
M
D
R
L
L
E
A
S
L
E
E
L
I
E
V
E
E
V
G
E
L
T
A
R
A
I
L
E
T
L
K
D
P
A
F
R
D
L
V
R
R
L
K
E
A
--
G
V
S
M
E
S
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Fugue
74.74
43%
-68
- C4 -
1DGS
2
DNLJ_THEFI
A:
[1-581]
-
M
T
R
E
E
A
R
R
R
I
N
E
---
L
R
D
L
I
R
Y
H
N
Y
R
Y
Y
V
L
A
D
P
E
I
S
D
A
E
Y
D
R
L
L
R
E
L
K
E
L
E
E
R
F
P
E
F
K
S
P
D
S
P
T
E
Q
V
G
A
R
P
-
L
E
P
T
F
R
P
V
R
H
P
T
R
M
Y
S
L
D
N
A
F
T
Y
E
E
V
L
A
F
E
E
R
L
E
R
E
A
------------
E
A
P
S
L
Y
T
V
E
H
K
V
D
G
L
S
V
-
L
Y
Y
E
E
G
V
W
S
T
--
G
S
G
D
G
E
V
G
E
E
V
T
Q
N
L
L
T
I
P
T
I
P
R
R
L
---
K
---
G
V
P
--
D
R
L
E
--
V
R
G
E
V
Y
M
P
I
E
A
F
L
R
L
N
E
E
L
E
E
R
G
E
K
V
F
K
N
P
R
N
A
A
A
G
S
L
R
Q
K
D
P
R
V
T
A
K
R
G
L
R
--
A
T
F
Y
A
L
G
---
L
G
L
G
-
L
EES
G
L
K
S
Q
Y
E
L
L
L
W
L
K
E
K
G
F
P
V
E
H
C
Y
E
K
A
L
G
A
E
G
V
E
E
V
Y
R
R
G
L
A
Q
R
H
A
L
P
F
E
A
D
G
V
V
L
K
L
D
D
L
T
L
W
G
E
L
G
Y
T
A
R
A
P
R
F
A
L
A
Y
K
F
P
A
E
E
K
E
T
R
L
L
D
V
V
F
Q
V
G
R
T
G
R
V
T
P
V
G
V
L
E
P
V
F
I
E
G
S
E
V
S
R
V
T
L
H
N
E
S
Y
I
E
E
L
D
I
R
I
G
D
W
V
L
V
H
K
A
G
G
V
I
P
E
V
L
R
V
L
K
E
R
R
T
G
K
E
R
P
I
R
W
P
E
A
C
P
E
C
G
H
R
L
V
K
E
G
K
V
H
R
C
P
N
P
----------------
L
C
P
A
K
R
F
E
A
I
R
H
Y
A
S
R
K
A
M
D
I
E
G
L
G
E
K
L
I
E
R
L
L
E
K
G
L
V
R
D
V
A
D
L
Y
H
L
R
K
E
D
L
L
G
L
E
R
M
G
E
K
S
A
Q
N
L
L
R
Q
I
E
E
S
K
H
R
G
L
E
R
L
L
Y
A
L
G
L
P
G
V
G
E
V
L
A
R
N
L
A
R
R
F
G
T
M
D
R
L
L
E
A
S
L
E
E
L
I
E
V
E
E
V
G
E
L
T
A
R
A
I
L
E
T
L
K
D
P
A
F
R
D
L
V
R
R
L
K
E
A
--
G
V
S
M
E
S
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
72.69
45%
-76
- C4 -
1V9P
2
DNLJ_THEFI
B:
[4-535]
----
E
E
A
R
R
R
I
N
E
---
L
R
D
L
I
R
Y
H
N
Y
R
Y
Y
V
L
A
D
P
E
I
S
D
A
E
Y
D
R
L
L
R
E
L
K
E
L
E
E
R
F
P
E
F
K
S
P
D
S
P
T
E
Q
V
G
A
R
P
L
E
P
-
T
F
R
P
V
R
H
P
T
R
M
Y
S
L
D
N
A
F
T
Y
E
E
V
L
A
F
E
E
R
L
E
R
A
L
G
R
K
R
P
----------
F
L
Y
T
V
E
H
K
V
D
G
L
S
V
N
L
Y
Y
E
E
G
V
L
V
F
G
A
T
R
G
D
G
E
V
G
E
E
V
T
Q
N
L
L
T
I
P
T
I
P
R
R
L
---
K
---
G
V
P
--
D
R
L
E
--
V
R
G
E
V
Y
M
P
I
E
A
F
L
R
L
N
E
E
L
E
E
R
G
E
K
V
F
K
N
P
R
N
A
A
A
G
S
L
R
Q
K
D
P
R
V
T
A
K
R
G
L
R
AT
F
Y
A
L
G
L
G
---
L
E
E
S
-
G
---
L
-
K
S
Q
Y
E
L
L
L
W
L
K
E
K
G
F
P
V
E
H
G
Y
E
K
A
L
G
A
E
G
V
E
E
V
Y
R
R
F
L
A
Q
R
H
A
L
P
F
E
A
D
G
V
V
V
K
L
D
D
L
A
L
W
R
E
L
G
Y
T
A
R
A
P
R
F
A
L
A
Y
K
F
P
A
E
E
K
E
T
R
L
L
D
V
V
F
Q
V
G
R
T
G
R
V
T
P
V
G
V
L
E
P
V
F
I
E
G
S
E
V
S
R
V
T
L
H
N
E
S
Y
I
E
E
L
D
I
R
I
G
D
W
V
L
V
H
K
A
G
G
V
I
P
E
V
L
R
V
L
K
E
R
R
T
G
E
E
R
P
I
R
W
P
E
T
C
P
E
C
G
H
R
L
--------------
V
K
E
G
-
K
V
H
R
C
P
N
P
L
-
C
P
A
K
R
F
E
A
I
R
H
Y
A
S
R
K
A
M
D
I
E
G
L
G
E
K
L
I
E
R
L
L
E
K
G
L
V
R
D
V
A
D
L
Y
H
L
R
K
E
D
L
L
G
L
E
R
M
G
E
K
S
A
Q
N
L
L
R
Q
I
E
E
S
K
H
R
G
L
E
R
L
L
Y
A
L
G
L
P
G
V
G
E
V
L
A
R
N
L
A
R
R
F
G
T
M
D
R
L
L
E
A
S
L
E
E
L
L
E
V
E
E
V
G
E
L
T
A
R
A
I
L
E
T
L
K
D
P
A
F
R
D
L
V
R
R
L
K
E
A
G
V
S
M
E
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
72.23
45%
-81
- C4 -
1V9P
2
DNLJ_THEFI
A:
[4-535]
----
E
E
A
R
R
R
I
N
E
---
L
R
D
L
I
R
Y
H
N
Y
R
Y
Y
V
L
A
D
P
E
I
S
D
A
E
Y
D
R
L
L
R
E
L
K
E
L
E
E
R
F
P
E
F
K
S
P
D
S
P
T
E
Q
V
G
A
R
P
L
E
P
-
T
F
R
P
V
R
H
P
T
R
M
Y
S
L
D
N
A
F
T
Y
E
E
V
L
A
F
E
E
R
L
E
R
A
L
G
R
K
R
P
----------
F
L
Y
T
V
E
H
K
V
D
G
L
S
V
N
L
Y
Y
E
E
G
V
L
V
F
G
A
T
R
G
D
G
E
V
G
E
E
V
T
Q
N
L
L
T
I
P
T
I
P
R
R
L
---
K
---
G
V
P
--
D
R
L
E
--
V
R
G
E
V
Y
M
P
I
E
A
F
L
R
L
N
E
E
L
E
E
R
G
E
K
V
F
K
N
P
R
N
A
A
A
G
S
L
R
Q
K
D
P
R
V
T
A
K
R
G
L
R
A
T
F
Y
A
L
G
L
G
---
L
E
E
S
-
G
---
L
-
K
S
Q
Y
E
L
L
L
W
L
K
E
K
G
F
P
V
E
H
G
Y
E
K
A
L
G
A
E
G
V
E
E
V
Y
R
R
F
L
A
Q
R
H
A
L
P
F
E
A
D
G
V
V
V
K
L
D
D
L
A
L
W
R
E
L
G
Y
T
A
R
A
P
R
F
A
L
A
Y
K
F
P
A
E
E
K
E
T
R
L
L
D
V
V
F
Q
V
G
R
T
G
R
V
T
P
V
G
V
L
E
P
V
F
I
E
G
S
E
V
S
R
V
T
L
H
N
E
S
Y
I
E
E
L
D
I
R
I
G
D
W
V
L
V
H
K
A
G
G
V
I
P
E
V
L
R
V
L
K
E
R
R
T
G
E
E
R
P
I
R
W
P
E
T
C
P
E
C
G
H
R
L
--------------
V
K
E
G
-
K
V
H
R
C
P
N
P
L
-
C
P
A
K
R
F
E
A
I
R
H
Y
A
S
R
K
A
M
D
I
E
G
L
G
E
K
L
I
E
R
L
L
E
K
G
L
V
R
D
V
A
D
L
Y
H
L
R
K
E
D
L
L
G
L
E
R
M
G
E
K
S
A
Q
N
L
L
R
Q
I
E
E
S
K
H
R
G
L
E
R
L
L
Y
A
L
G
L
P
G
V
G
E
V
L
A
R
N
L
A
R
R
F
G
T
M
D
R
L
L
E
A
S
L
E
E
L
L
E
V
E
E
V
G
E
L
T
A
R
A
I
L
E
T
L
K
D
P
A
F
R
D
L
V
R
R
L
K
E
A
G
V
S
M
E
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
58.11
54%
-59
- C4 -
3PN1
2
DNLJ_HAEIN
A:
[1-318]
M
T
N
I
Q
T
---
Q
L
D
N
---
L
R
K
T
L
R
Q
Y
E
Y
E
Y
H
V
L
D
N
P
S
V
P
D
S
E
Y
D
R
L
F
H
Q
L
K
A
L
E
L
E
H
P
E
F
L
T
S
D
S
P
T
Q
R
V
G
A
K
P
-
L
S
-
G
F
S
Q
I
R
H
E
I
P
M
L
S
L
D
N
A
F
S
D
A
E
F
N
A
F
V
K
R
I
E
D
R
L
I
-
L
L
P
--------
K
P
L
T
F
C
C
E
P
K
L
D
G
L
A
V
S
I
L
Y
V
N
G
E
L
T
Q
A
A
T
R
G
D
G
T
T
G
E
D
I
T
A
N
I
R
T
I
R
N
V
P
L
Q
L
L
-
T
D
---
N
P
P
--
A
R
L
E
--
V
R
G
E
V
F
M
P
H
A
G
F
E
R
L
N
K
Y
A
L
E
H
N
E
K
T
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
P
N
I
T
S
K
R
P
L
V
--
L
N
A
Y
G
I
G
---
I
A
E
G
-
V
D--
L
P
T
T
H
Y
A
R
L
Q
W
L
K
S
I
G
I
P
V
N
P
E
I
R
L
C
N
G
A
D
E
V
L
G
F
Y
R
D
I
Q
N
K
R
S
S
L
G
Y
D
I
D
G
T
V
L
K
I
N
D
I
A
L
Q
N
E
L
G
F
I
S
K
A
P
R
W
A
I
A
Y
K
F
P
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
57.76
41%
-53
- C4 -
3SGI
1
DNLJ_MYCTU
A:
[8-415]
----
Q
T
A
P
E
V
L
R
Q
W
Q
A
L
A
E
E
V
R
E
H
Q
F
R
Y
Y
V
R
D
A
P
I
I
S
D
A
E
F
D
E
L
L
R
R
L
E
A
L
E
E
Q
H
P
E
L
R
T
P
D
S
P
T
Q
L
V
G
G
A
G
F
A
T
-
D
F
E
P
V
D
H
L
E
R
M
L
S
L
D
N
A
F
T
A
D
E
L
A
A
W
A
G
R
I
H
A
E
V
G
D
------------
A
A
H
Y
L
C
E
L
K
I
D
G
V
A
L
S
L
V
Y
R
E
G
R
L
T
R
A
S
T
R
G
D
G
R
T
G
E
D
V
T
L
N
A
R
T
I
A
D
V
P
E
R
L
T
P
G
D
---
D
Y
P
VP
E
V
L
E
--
V
R
G
E
V
F
F
R
L
D
D
F
Q
A
L
N
A
S
L
V
E
E
G
K
A
P
F
A
N
P
R
N
S
A
A
G
S
L
R
Q
K
D
P
A
V
T
A
R
R
R
L
R
--
M
I
C
H
G
L
G
---
H
V
E
G
-
F
---
R
P
A
T
L
H
Q
A
Y
L
A
L
R
A
W
G
L
P
V
S
E
H
T
T
L
A
T
D
L
A
G
V
R
E
R
I
D
Y
W
G
E
H
R
H
E
V
D
H
E
I
D
G
V
V
V
K
V
D
E
V
A
L
Q
R
R
L
G
S
T
S
R
A
P
R
W
A
I
A
Y
K
Y
P
P
E
E
A
Q
T
K
L
L
D
I
R
V
N
V
G
R
T
G
R
I
T
P
F
A
F
M
T
P
V
K
V
A
G
S
T
V
G
Q
A
T
L
H
N
A
S
E
I
K
R
K
G
V
L
I
G
D
T
V
V
I
R
K
A
G
D
V
I
P
E
V
L
G
P
V
V
E
L
R
D
G
S
E
R
E
F
I
M
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
57.57
57%
-56
- C4 -
3UQ8
2
DNLJ_HAEIN
A:
[2-321]
------
I
Q
T
Q
L
D
N
---
L
R
K
T
L
R
Q
Y
E
Y
E
Y
H
V
L
D
N
P
S
V
P
D
S
E
Y
D
R
L
F
H
Q
L
K
A
L
E
L
E
H
P
E
F
L
T
S
D
S
P
T
Q
R
V
G
A
K
P
-
L
S
-
G
F
S
Q
I
R
H
E
I
P
M
L
S
L
D
N
A
F
S
D
A
E
F
N
A
F
V
A
R
I
E
D
R
L
I
L
L
---------
P
A
P
L
T
F
C
C
E
P
K
L
D
G
L
A
V
S
I
L
Y
V
N
G
E
L
T
Q
A
A
T
R
G
D
G
T
T
G
E
D
I
T
A
N
I
R
T
I
R
N
V
P
L
Q
L
L
-
T
D
---
N
P
P
--
A
R
L
E
--
V
R
G
E
V
F
M
P
H
A
G
F
E
R
L
N
K
Y
A
L
E
H
N
E
K
T
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
P
N
I
T
S
K
R
P
L
V
--
L
N
A
Y
G
I
G
---
I
A
E
G
-
V
D--
L
P
T
T
H
Y
A
R
L
Q
W
L
K
S
I
G
I
P
V
N
P
E
I
R
L
C
N
G
A
D
E
V
L
G
F
Y
R
D
I
Q
N
K
R
S
S
L
G
Y
D
I
D
G
T
V
L
K
I
N
D
I
A
L
Q
N
E
L
G
F
I
S
K
A
P
R
W
A
I
A
Y
K
F
P
A
Q
E
E
L
T
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
57.16
56%
-57
- C4 -
3UQ8
2
DNLJ_HAEIN
A:
[5-321]
---------
Q
L
D
N
---
L
R
K
T
L
R
Q
Y
E
Y
E
Y
H
V
L
D
N
P
S
V
P
D
S
E
Y
D
R
L
F
H
Q
L
K
A
L
E
L
E
H
P
E
F
L
T
S
D
S
P
T
Q
R
V
G
A
K
P
-
L
S
-
G
F
S
Q
I
R
H
E
I
P
M
L
S
L
D
N
A
F
S
D
A
E
F
N
A
F
V
A
R
I
E
D
R
L
I
-
L
L
P
--------
A
P
L
T
F
C
C
E
P
K
L
D
G
L
A
V
S
I
L
Y
V
N
G
E
L
T
Q
A
A
T
R
G
D
G
T
T
G
E
D
I
T
A
N
I
R
T
I
R
N
V
P
L
Q
L
L
-
T
D
---
N
P
P
--
A
R
L
E
--
V
R
G
E
V
F
M
P
H
A
G
F
E
R
L
N
K
Y
A
L
E
H
N
E
K
T
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
P
N
I
T
S
K
R
P
L
V
--
L
N
A
Y
G
I
G
---
I
A
E
G
-
V
D--
L
P
T
T
H
Y
A
R
L
Q
W
L
K
S
I
G
I
P
V
N
P
E
I
R
L
C
N
G
A
D
E
V
L
G
F
Y
R
D
I
Q
N
K
R
S
S
L
G
Y
D
I
D
G
T
V
L
K
I
N
D
I
A
L
Q
N
E
L
G
F
I
S
K
A
P
R
W
A
I
A
Y
K
F
P
A
Q
E
E
L
T
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
56.65
42%
-50
- C4 -
3SGI
1
DNLJ_MYCTU
A:
[8-415]
-
Q
T
A
P
E
V
L
R
Q
W
Q
A
---
L
A
E
E
V
R
E
H
Q
F
R
Y
Y
V
R
D
A
P
I
I
S
D
A
E
F
D
E
L
L
R
R
L
E
A
L
E
E
Q
H
P
E
L
R
T
P
D
S
P
T
Q
L
V
G
G
A
G
F
A
T
-
D
F
E
P
V
D
H
L
E
R
M
L
S
L
D
N
A
F
T
A
D
E
L
A
A
W
A
G
R
I
H
A
E
V
G
------------
D
A
A
H
Y
L
C
E
L
K
I
D
G
V
A
L
S
L
V
Y
R
E
G
R
L
T
R
A
S
T
R
G
D
G
R
T
G
E
D
V
T
L
N
A
R
T
I
A
D
V
P
E
R
L
T
-
P
G
DDY
P
V
P
--
E
V
L
E
--
V
R
G
E
V
F
F
R
L
D
D
F
Q
A
L
N
A
S
L
V
E
E
G
K
A
P
F
A
N
P
R
N
S
A
A
G
S
L
R
Q
K
D
P
A
V
T
A
R
R
R
L
R
--
M
I
C
H
G
L
G
---
H
V
E
G
-
F
---
R
P
A
T
L
H
Q
A
Y
L
A
L
R
A
W
G
L
P
V
S
E
H
T
T
L
A
T
D
L
A
G
V
R
E
R
I
D
Y
W
G
E
H
R
H
E
V
D
H
E
I
D
G
V
V
V
K
V
D
E
V
A
L
Q
R
R
L
G
S
T
S
R
A
P
R
W
A
I
A
Y
K
Y
P
P
E
E
A
Q
T
K
L
L
D
I
R
V
N
V
G
R
T
G
R
I
T
P
F
A
F
M
T
P
V
K
V
A
G
S
T
V
G
Q
A
T
L
H
N
A
S
E
I
K
R
K
G
V
L
I
G
D
T
V
V
I
R
K
A
G
D
V
I
P
E
V
L
G
P
V
V
E
L
R
D
G
S
E
R
E
F
I
M
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
56.30
47%
-57
- C4 -
4EEQ
4
DNLJ_ENTFA
A:
[10-317]
-----
A
A
T
T
R
A
Q
E
---
L
R
K
Q
L
N
Q
Y
S
H
E
Y
Y
V
K
D
Q
P
S
V
E
D
Y
V
Y
D
R
L
Y
K
E
L
V
D
I
E
T
E
F
P
D
L
I
T
P
D
S
P
T
Q
R
V
G
G
K
V
-
L
S
-
G
F
E
K
A
P
H
D
I
P
M
Y
S
L
N
D
G
F
S
K
E
D
I
F
A
F
D
E
R
V
R
K
A
I
------------
G
K
P
V
A
Y
C
C
E
L
K
I
D
G
L
A
I
S
L
R
Y
E
N
G
V
F
V
R
G
A
T
R
G
D
G
T
V
G
E
N
I
T
E
N
L
R
T
V
R
S
V
P
M
R
L
T
-
E
------
P
--
I
S
V
E
--
V
R
G
E
C
Y
M
P
K
Q
S
F
V
A
L
N
E
E
R
E
E
N
G
Q
D
I
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
T
K
I
V
A
K
R
N
L
N
--
T
F
L
Y
T
V
A
---
D
F
G
P
-
M
---
K
A
K
T
Q
F
E
A
L
E
E
L
S
A
I
G
F
R
T
N
P
E
R
Q
L
C
Q
S
I
D
E
V
W
A
Y
I
E
E
Y
H
E
K
R
S
T
L
P
Y
E
I
D
G
I
V
I
K
V
N
E
F
A
L
Q
D
E
L
G
F
T
V
K
A
P
R
W
A
I
A
Y
K
F
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
55.30
47%
-58
- C4 -
4EFB
4
DNLJ_ENTFA
A:
[10-317]
-----
A
A
T
T
R
A
Q
E
---
L
R
K
Q
L
N
Q
Y
S
H
E
Y
Y
V
K
D
Q
P
S
V
E
D
Y
V
Y
D
R
L
Y
K
E
L
V
D
I
E
T
E
F
P
D
L
I
T
P
D
S
P
T
Q
R
V
G
G
K
V
-
L
S
-
G
F
E
K
A
P
H
D
I
P
M
Y
S
L
N
D
G
F
S
K
E
D
I
F
A
F
D
E
R
V
R
K
A
I
------------
G
K
P
V
A
Y
C
C
E
L
K
I
D
G
L
A
I
S
L
R
Y
E
N
G
V
F
V
R
G
A
T
R
G
D
G
T
V
G
E
N
I
T
E
N
L
R
T
V
R
S
V
P
M
R
L
T
-
E
------
P
--
I
S
V
E
--
V
R
G
E
C
Y
M
P
K
Q
S
F
V
A
L
N
E
E
R
E
E
N
G
Q
D
I
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
T
K
I
V
A
K
R
N
L
N
--
T
F
L
Y
T
V
A
---
D
F
G
P
-
M
---
K
A
K
T
Q
F
E
A
L
E
E
L
S
A
I
G
F
R
T
N
P
E
R
Q
L
C
Q
S
I
D
E
V
W
A
Y
I
E
E
Y
H
E
K
R
S
T
L
P
Y
E
I
D
G
I
V
I
K
V
N
E
F
A
L
Q
D
E
L
G
F
T
V
K
A
P
R
W
A
I
A
Y
K
F
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
55.29
47%
-57
- C4 -
3BA9
9
DNLJ_ENTFA
A:
[10-317]
-----
A
A
T
T
R
A
Q
E
---
L
R
K
Q
L
N
Q
Y
S
H
E
Y
Y
V
K
D
Q
P
S
V
E
D
Y
V
Y
D
R
L
Y
K
E
L
V
D
I
E
T
E
F
P
D
L
I
T
P
D
S
P
T
Q
R
V
G
G
K
V
-
L
S
-
G
F
E
K
A
P
H
D
I
P
M
Y
S
L
N
D
G
F
S
K
E
D
I
F
A
F
D
E
R
V
R
K
A
I
------------
G
K
P
V
A
Y
C
C
E
L
K
I
D
G
L
A
I
S
L
R
Y
E
N
G
V
F
V
R
G
A
T
R
G
D
G
T
V
G
E
N
I
T
E
N
L
R
T
V
R
S
V
P
M
R
L
T
-
E
------
P
--
I
S
V
E
--
V
R
G
E
C
Y
M
P
K
Q
S
F
V
A
L
N
E
E
R
E
E
N
G
Q
D
I
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
T
K
I
V
A
K
R
N
L
N
--
T
F
L
Y
T
V
A
---
D
F
G
P
-
M
---
K
A
K
T
Q
F
E
A
L
E
E
L
S
A
I
G
F
R
T
N
P
E
R
Q
L
C
Q
S
I
D
E
V
W
A
Y
I
E
E
Y
H
E
K
R
S
T
L
P
Y
E
I
D
G
I
V
I
K
V
N
E
F
A
L
Q
D
E
L
G
F
T
V
K
A
P
R
W
A
I
A
Y
K
F
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
55.24
47%
-57
- C4 -
1TA8
4
DNLJ_ENTFA
A:
[10-317]
-----
A
A
T
T
R
A
Q
E
---
L
R
K
Q
L
N
Q
Y
S
H
E
Y
Y
V
K
D
Q
P
S
V
E
D
Y
V
Y
D
R
L
Y
K
E
L
V
D
I
E
T
E
F
P
D
L
I
T
P
D
S
P
T
Q
R
V
G
G
K
V
-
L
S
-
G
F
E
K
A
P
H
D
I
P
M
Y
S
L
N
D
G
F
S
K
E
D
I
F
A
F
D
E
R
V
R
K
A
I
------------
G
K
P
V
A
Y
C
C
E
L
K
I
D
G
L
A
I
S
L
R
Y
E
N
G
V
F
V
R
G
A
T
R
G
D
G
T
V
G
E
N
I
T
E
N
L
R
T
V
R
S
V
P
M
R
L
T
-
E
------
P
--
I
S
V
E
--
V
R
G
E
C
Y
M
P
K
Q
S
F
V
A
L
N
E
E
R
E
E
N
G
Q
D
I
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
T
K
I
V
A
K
R
N
L
N
--
T
F
L
Y
T
V
A
---
D
F
G
P
-
M
---
K
A
K
T
Q
F
E
A
L
E
E
L
S
A
I
G
F
R
T
N
P
E
R
Q
L
C
Q
S
I
D
E
V
W
A
Y
I
E
E
Y
H
E
K
R
S
T
L
P
Y
E
I
D
G
I
V
I
K
V
N
E
F
A
L
Q
D
E
L
G
F
T
V
K
A
P
R
W
A
I
A
Y
K
F
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
55.17
47%
-56
- C4 -
4EFE
4
DNLJ_ENTFA
A:
[10-317]
-----
A
A
T
T
R
A
Q
E
---
L
R
K
Q
L
N
Q
Y
S
H
E
Y
Y
V
K
D
Q
P
S
V
E
D
Y
V
Y
D
R
L
Y
K
E
L
V
D
I
E
T
E
F
P
D
L
I
T
P
D
S
P
T
Q
R
V
G
G
K
V
-
L
S
-
G
F
E
K
A
P
H
D
I
P
M
Y
S
L
N
D
G
F
S
K
E
D
I
F
A
F
D
E
R
V
R
K
A
I
------------
G
K
P
V
A
Y
C
C
E
L
K
I
D
G
L
A
I
S
L
R
Y
E
N
G
V
F
V
R
G
A
T
R
G
D
G
T
V
G
E
N
I
T
E
N
L
R
T
V
R
S
V
P
M
R
L
T
-
E
------
P
--
I
S
V
E
--
V
R
G
E
C
Y
M
P
K
Q
S
F
V
A
L
N
E
E
R
E
E
N
G
Q
D
I
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
T
K
I
V
A
K
R
N
L
N
--
T
F
L
Y
T
V
A
---
D
F
G
P
-
M
---
K
A
K
T
Q
F
E
A
L
E
E
L
S
A
I
G
F
R
T
N
P
E
R
Q
L
C
Q
S
I
D
E
V
W
A
Y
I
E
E
Y
H
E
K
R
S
T
L
P
Y
E
I
D
G
I
V
I
K
V
N
E
F
A
L
Q
D
E
L
G
F
T
V
K
A
P
R
W
A
I
A
Y
K
F
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
55.04
47%
-56
- C4 -
3BAA
8
DNLJ_ENTFA
A:
[10-317]
-----
A
A
T
T
R
A
Q
E
---
L
R
K
Q
L
N
Q
Y
S
H
E
Y
Y
V
K
D
Q
P
S
V
E
D
Y
V
Y
D
R
L
Y
K
E
L
V
D
I
E
T
E
F
P
D
L
I
T
P
D
S
P
T
Q
R
V
G
G
K
V
-
L
S
-
G
F
E
K
A
P
H
D
I
P
M
Y
S
L
N
D
G
F
S
K
E
D
I
F
A
F
D
E
R
V
R
K
A
I
------------
G
K
P
V
A
Y
C
C
E
L
K
I
D
G
L
A
I
S
L
R
Y
E
N
G
V
F
V
R
G
A
T
R
G
D
G
T
V
G
E
N
I
T
E
N
L
R
T
V
R
S
V
P
M
R
L
T
-
E
------
P
--
I
S
V
E
--
V
R
G
E
C
Y
M
P
K
Q
S
F
V
A
L
N
E
E
R
E
E
N
G
Q
D
I
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
T
K
I
V
A
K
R
N
L
N
--
T
F
L
Y
T
V
A
---
D
F
G
P
-
M
---
K
A
K
T
Q
F
E
A
L
E
E
L
S
A
I
G
F
R
T
N
P
E
R
Q
L
C
Q
S
I
D
E
V
W
A
Y
I
E
E
Y
H
E
K
R
S
T
L
P
Y
E
I
D
G
I
V
I
K
V
N
E
F
A
L
Q
D
E
L
G
F
T
V
K
A
P
R
W
A
I
A
Y
K
F
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
54.86
47%
-59
- C4 -
3BA8
5
DNLJ_ENTFA
A:
[10-317]
-----
A
A
T
T
R
A
Q
E
---
L
R
K
Q
L
N
Q
Y
S
H
E
Y
Y
V
K
D
Q
P
S
V
E
D
Y
V
Y
D
R
L
Y
K
E
L
V
D
I
E
T
E
F
P
D
L
I
T
P
D
S
P
T
Q
R
V
G
G
K
V
-
L
S
-
G
F
E
K
A
P
H
D
I
P
M
Y
S
L
N
D
G
F
S
K
E
D
I
F
A
F
D
E
R
V
R
K
A
I
------------
G
K
P
V
A
Y
C
C
E
L
K
I
D
G
L
A
I
S
L
R
Y
E
N
G
V
F
V
R
G
A
T
R
G
D
G
T
V
G
E
N
I
T
E
N
L
R
T
V
R
S
V
P
M
R
L
T
-
E
------
P
--
I
S
V
E
--
V
R
G
E
C
Y
M
P
K
Q
S
F
V
A
L
N
E
E
R
E
E
N
G
Q
D
I
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
T
K
I
V
A
K
R
N
L
N
--
T
F
L
Y
T
V
A
---
D
F
G
P
-
M
---
K
A
K
T
Q
F
E
A
L
E
E
L
S
A
I
G
F
R
T
N
P
E
R
Q
L
C
Q
S
I
D
E
V
W
A
Y
I
E
E
Y
H
E
K
R
S
T
L
P
Y
E
I
D
G
I
V
I
K
V
N
E
F
A
L
Q
D
E
L
G
F
T
V
K
A
P
R
W
A
I
A
Y
K
F
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
54.84
47%
-57
- C4 -
3BAB
7
DNLJ_ENTFA
A:
[10-317]
-----
A
A
T
T
R
A
Q
E
---
L
R
K
Q
L
N
Q
Y
S
H
E
Y
Y
V
K
D
Q
P
S
V
E
D
Y
V
Y
D
R
L
Y
K
E
L
V
D
I
E
T
E
F
P
D
L
I
T
P
D
S
P
T
Q
R
V
G
G
K
V
-
L
S
-
G
F
E
K
A
P
H
D
I
P
M
Y
S
L
N
D
G
F
S
K
E
D
I
F
A
F
D
E
R
V
R
K
A
I
------------
G
K
P
V
A
Y
C
C
E
L
K
I
D
G
L
A
I
S
L
R
Y
E
N
G
V
F
V
R
G
A
T
R
G
D
G
T
V
G
E
N
I
T
E
N
L
R
T
V
R
S
V
P
M
R
L
T
-
E
------
P
--
I
S
V
E
--
V
R
G
E
C
Y
M
P
K
Q
S
F
V
A
L
N
E
E
R
E
E
N
G
Q
D
I
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
T
K
I
V
A
K
R
N
L
N
--
T
F
L
Y
T
V
A
---
D
F
G
P
-
M
---
K
A
K
T
Q
F
E
A
L
E
E
L
S
A
I
G
F
R
T
N
P
E
R
Q
L
C
Q
S
I
D
E
V
W
A
Y
I
E
E
Y
H
E
K
R
S
T
L
P
Y
E
I
D
G
I
V
I
K
V
N
E
F
A
L
Q
D
E
L
G
F
T
V
K
A
P
R
W
A
I
A
Y
K
F
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
54.66
47%
-55
- C4 -
4LH6
5
DNLJ_ENTFA
A:
[10-320]
-----
A
A
T
T
R
A
Q
E
---
L
R
K
Q
L
N
Q
Y
S
H
E
Y
Y
V
K
D
Q
P
S
V
E
D
Y
V
Y
D
R
L
Y
K
E
L
V
D
I
E
T
E
F
P
D
L
I
T
P
D
S
P
T
Q
R
V
G
G
K
V
-
L
S
-
G
F
E
K
A
P
H
D
I
P
M
Y
S
L
N
D
G
F
S
K
E
D
I
F
A
F
D
E
R
V
R
K
A
I
------------
G
K
P
V
A
Y
C
C
E
L
K
I
D
G
L
A
I
S
L
R
Y
E
N
G
V
F
V
R
G
A
T
R
G
D
G
T
V
G
E
N
I
T
E
N
L
R
T
V
R
S
V
P
M
R
L
T
-
E
------
P
--
I
S
V
E
--
V
R
G
E
C
Y
M
P
K
Q
S
F
V
A
L
N
E
E
R
E
E
N
G
Q
D
I
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
T
K
I
V
A
K
R
N
L
N
--
T
F
L
Y
T
V
A
---
D
F
G
P
-
M
---
K
A
K
T
Q
F
E
A
L
E
E
L
S
A
I
G
F
R
T
N
P
E
R
Q
L
C
Q
S
I
D
E
V
W
A
Y
I
E
E
Y
H
E
K
R
S
T
L
P
Y
E
I
D
G
I
V
I
K
V
N
E
F
A
L
Q
D
E
L
G
F
T
V
K
A
P
R
W
A
I
A
Y
K
F
P
P
E
E
A
E
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
53.94
47%
-55
- C4 -
4LH7
4
DNLJ_ENTFA
A:
[10-320]
-----
A
A
T
T
R
A
Q
E
---
L
R
K
Q
L
N
Q
Y
S
H
E
Y
Y
V
K
D
Q
P
S
V
E
D
Y
V
Y
D
R
L
Y
K
E
L
V
D
I
E
T
E
F
P
D
L
I
T
P
D
S
P
T
Q
R
V
G
G
K
V
-
L
S
-
G
F
E
K
A
P
H
D
I
P
M
Y
S
L
N
D
G
F
S
K
E
D
I
F
A
F
D
E
R
V
R
K
A
I
------------
G
K
P
V
A
Y
C
C
E
L
K
I
D
G
L
A
I
S
L
R
Y
E
N
G
V
F
V
R
G
A
T
R
G
D
G
T
V
G
E
N
I
T
E
N
L
R
T
V
R
S
V
P
M
R
L
T
-
E
------
P
--
I
S
V
E
--
V
R
G
E
C
Y
M
P
K
Q
S
F
V
A
L
N
E
E
R
E
E
N
G
Q
D
I
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
T
K
I
V
A
K
R
N
L
N
--
T
F
L
Y
T
V
A
---
D
F
G
P
-
M
---
K
A
K
T
Q
F
E
A
L
E
E
L
S
A
I
G
F
R
T
N
P
E
R
Q
L
C
Q
S
I
D
E
V
W
A
Y
I
E
E
Y
H
E
K
R
S
T
L
P
Y
E
I
D
G
I
V
I
K
V
N
E
F
A
L
Q
D
E
L
G
F
T
V
K
A
P
R
W
A
I
A
Y
K
F
P
P
E
E
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
52.63
47%
-51
- C4 -
1ZAU
1
DNLJ_MYCTU
A:
[9-328]
--
T
A
P
E
V
L
R
Q
W
Q
A
---
L
A
E
E
V
R
E
H
Q
F
R
Y
Y
V
R
D
A
P
I
I
S
D
A
E
F
D
E
L
L
R
R
L
E
A
L
E
E
Q
H
P
E
L
R
T
P
D
S
P
T
Q
L
V
G
G
A
G
F
A
T
-
D
F
E
P
V
D
H
L
E
R
M
L
S
L
D
N
A
F
T
A
D
E
L
A
A
W
A
G
R
I
H
A
E
V
G
------------
D
A
A
H
Y
L
C
E
L
K
I
D
G
V
A
L
S
L
V
Y
R
E
G
R
L
T
R
A
S
T
R
G
D
G
R
T
G
E
D
V
T
L
N
A
R
T
I
A
D
V
P
E
R
L
T
-
P
G
D
DY
P
V
P
--
E
V
L
E
--
V
R
G
E
V
F
F
R
L
D
D
F
Q
A
L
N
A
S
L
V
E
E
G
K
A
P
F
A
N
P
R
N
S
A
A
G
S
L
R
Q
K
D
P
A
V
T
A
R
R
R
L
R
--
M
I
C
H
G
L
G
---
H
V
E
G
-
F
---
R
P
A
T
L
H
Q
A
Y
L
A
L
R
A
W
G
L
P
V
S
E
H
T
T
L
A
T
D
L
A
G
V
R
E
R
I
D
Y
W
G
E
H
R
H
E
V
D
H
E
I
D
G
V
V
V
K
V
D
E
V
A
L
Q
R
R
L
G
S
T
S
R
A
P
R
W
A
I
A
Y
K
Y
P
P
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
52.36
45%
-51
- C4 -
4CC5
2
DNLJ_STAAU
A:
[5-309]
-------
S
S
R
V
N
E
---
L
H
D
L
L
N
Q
Y
S
Y
E
Y
Y
V
E
D
N
P
S
V
P
D
S
E
Y
D
K
L
L
H
E
L
I
K
I
E
E
E
H
P
E
Y
K
T
V
D
S
P
T
V
R
V
G
G
E
A
-
Q
A
-
S
F
N
K
V
N
H
D
T
P
M
L
S
L
G
N
A
F
N
E
D
D
L
R
K
F
D
Q
R
I
R
E
Q
I
G
N
-------------
V
E
Y
M
C
E
L
K
I
D
G
L
A
V
S
L
K
Y
V
D
G
Y
F
V
Q
G
L
T
R
G
D
G
T
T
G
E
D
I
T
E
N
L
K
T
I
H
A
I
P
L
K
M
K
-
E
------
P
--
L
N
V
E
--
V
R
G
E
A
Y
M
P
R
R
S
F
L
R
L
N
E
E
K
E
K
N
D
E
Q
L
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
S
K
L
T
A
K
R
K
L
S
--
V
F
I
Y
S
V
N
---
D
F
T
D
-
F
---
N
A
R
S
Q
S
E
A
L
D
E
L
D
K
L
G
F
T
T
N
K
N
R
A
R
V
N
N
I
D
G
V
L
E
Y
I
E
K
W
T
S
Q
R
E
S
L
P
Y
D
I
D
G
I
V
I
K
V
N
D
L
D
Q
Q
D
E
M
G
F
T
Q
K
S
P
R
W
A
I
A
Y
K
F
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
51.66
45%
-53
- C4 -
4CC6
2
DNLJ_STAAU
A:
[5-309]
-------
S
S
R
V
N
E
---
L
H
D
L
L
N
Q
Y
S
Y
E
Y
Y
V
E
D
N
P
S
V
P
D
S
E
Y
D
K
L
L
H
E
L
I
K
I
E
E
E
H
P
E
Y
K
T
V
D
S
P
T
V
R
V
G
G
E
A
-
Q
A
-
S
F
N
K
V
N
H
D
T
P
M
L
S
L
G
N
A
F
N
E
D
D
L
R
K
F
D
Q
R
I
R
E
Q
I
G
N
-------------
V
E
Y
M
C
E
L
K
I
D
G
L
A
V
S
L
K
Y
V
D
G
Y
F
V
Q
G
L
T
R
G
D
G
T
T
G
E
D
I
T
E
N
L
K
T
I
H
A
I
P
L
K
M
K
-
E
------
P
--
L
N
V
E
--
V
R
G
E
A
Y
M
P
R
R
S
F
L
R
L
N
E
E
K
E
K
N
D
E
Q
L
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
S
K
L
T
A
K
R
K
L
S
--
V
F
I
Y
S
V
N
---
D
F
T
D
-
F
---
N
A
R
S
Q
S
E
A
L
D
E
L
D
K
L
G
F
T
T
N
K
N
R
A
R
V
N
N
I
D
G
V
L
E
Y
I
E
K
W
T
S
Q
R
E
S
L
P
Y
D
I
D
G
I
V
I
K
V
N
D
L
D
Q
Q
D
E
M
G
F
T
Q
K
S
P
R
W
A
I
A
Y
K
F
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
51.59
46%
-52
- C4 -
1ZAU
1
DNLJ_MYCTU
A:
[8-326]
----
Q
T
A
P
E
V
L
R
Q
WQA
L
A
E
E
V
R
E
H
Q
F
R
Y
Y
V
R
D
A
P
I
I
S
D
A
E
F
D
E
L
L
R
R
L
E
A
L
E
E
Q
H
P
E
L
R
T
P
D
S
P
T
Q
L
V
G
G
A
G
F
A
T
-
D
F
E
P
V
D
H
L
E
R
M
L
S
L
D
N
A
F
T
A
D
E
L
A
A
W
A
G
R
I
H
A
E
V
G
D
A
------------
A
H
Y
L
C
E
L
K
I
D
G
V
A
L
S
L
V
Y
R
E
G
R
L
T
R
A
S
T
R
G
D
G
R
T
G
E
D
V
T
L
N
A
R
T
I
A
D
V
P
E
R
L
T
P
G
D
---
D
Y
P
VP
E
V
L
E
--
V
R
G
E
V
F
F
R
L
D
D
F
Q
A
L
N
A
S
L
V
E
E
G
K
A
P
F
A
N
P
R
N
S
A
A
G
S
L
R
Q
K
D
P
A
V
T
A
R
R
R
L
R
--
M
I
C
H
G
L
G
---
H
V
E
G
-
F
---
R
P
A
T
L
H
Q
A
Y
L
A
L
R
A
W
G
L
P
V
S
E
H
T
T
L
A
T
D
L
A
G
V
R
E
R
I
D
Y
W
G
E
H
R
H
E
V
D
H
E
I
D
G
V
V
V
K
V
D
E
V
A
L
Q
R
R
L
G
S
T
S
R
A
P
R
W
A
I
A
Y
K
Y
P
P
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
49.99
41%
-53
- C4 -
4GLW
4
DNLJ_STRZP
B:
[3-304]
--------
K
R
M
N
E
---
L
V
A
L
L
N
----------------------
Y
R
E
L
V
E
L
E
T
A
Y
P
E
Q
V
L
A
D
S
P
T
H
R
V
G
G
K
V
-
L
D
-
G
F
E
K
Y
S
H
Q
Y
P
L
Y
S
L
Q
D
A
F
S
R
E
E
L
D
A
F
D
A
R
V
R
K
E
V
-------------
A
H
P
T
Y
I
C
E
L
K
I
D
G
L
S
I
S
L
T
Y
E
K
G
I
L
V
A
G
V
T
R
G
D
G
S
I
G
E
N
I
T
E
N
L
K
R
V
K
D
I
P
L
T
L
---------
P
--
E
E
L
D
I
T
V
R
G
E
C
Y
M
P
R
A
S
F
D
Q
V
N
Q
A
R
Q
E
N
G
E
P
E
F
A
N
P
R
N
A
A
A
G
T
L
R
Q
L
D
T
A
V
V
A
K
R
N
L
----
A
T
F
L
Y
Q
---
E
A
S
P
-
S
---
T
R
D
S
Q
E
K
G
L
K
Y
L
E
Q
L
G
F
V
V
N
P
K
R
I
L
A
E
N
I
D
E
I
W
N
F
I
Q
E
V
G
Q
E
R
E
N
L
P
Y
D
I
D
G
V
V
I
K
V
N
D
L
A
S
Q
E
E
L
G
F
T
V
K
A
P
K
W
A
V
A
Y
K
F
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
49.64
56%
-58
- C4 -
3BAC
4
DNLJ_HAEIN
A:
[6-260]
----------------------------------------------------------------------------
G
F
S
Q
I
R
H
E
I
P
M
L
S
L
D
N
A
F
S
D
A
E
F
N
A
F
V
K
R
I
E
D
R
L
I
-
L
L
P
--------
K
P
L
T
F
C
C
E
P
K
L
D
G
L
A
V
S
I
L
Y
V
N
G
E
L
T
Q
A
A
T
R
G
D
G
T
T
G
E
D
I
T
A
N
I
R
T
I
R
N
V
P
L
Q
L
L
-
T
D
---
N
P
P
--
A
R
L
E
--
V
R
G
E
V
F
M
P
H
A
G
F
E
R
L
N
K
Y
A
L
E
H
N
E
K
T
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
P
N
I
T
S
K
R
P
L
V
--
L
N
A
Y
G
I
G
---
I
A
E
G
-
V
G--
L
P
T
T
H
Y
A
R
L
Q
W
L
K
S
I
G
I
P
V
N
P
E
I
R
L
C
N
G
A
D
E
V
L
D
F
Y
Q
D
I
Q
N
K
R
S
S
L
G
Y
D
I
D
G
T
V
L
K
I
N
D
I
A
L
Q
N
E
L
G
F
I
S
K
A
P
R
W
A
I
A
Y
K
F
P
A
Q
E
E
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
48.92
41%
-49
- C4 -
4GLW
3
DNLJ_STRZP
A:
[3-305]
--------
K
R
M
N
E
--------------------------------
R
E
L
V
E
L
E
T
A
Y
P
E
Q
V
L
A
D
S
P
T
H
R
V
G
G
K
V
-
L
D
-
G
F
E
K
Y
S
H
Q
Y
P
L
Y
S
L
Q
D
A
F
S
R
E
E
L
D
A
F
D
A
R
V
R
K
E
V
-------------
A
H
P
T
Y
I
C
E
L
K
I
D
G
L
S
I
S
L
T
Y
E
K
G
I
L
V
A
G
V
T
R
G
D
G
S
I
G
E
N
I
T
E
N
L
K
R
V
K
D
I
P
L
T
L
---------
P
--
E
E
L
D
I
T
V
R
G
E
C
Y
M
P
R
A
S
F
D
Q
V
N
Q
A
R
Q
E
N
G
E
P
E
F
A
N
P
R
N
A
A
A
G
T
L
R
Q
L
D
T
A
V
V
A
K
R
N
L
----
A
T
F
L
Y
Q
---
E
A
S
P
-
S
---
T
R
D
S
Q
E
K
G
L
K
Y
L
E
Q
L
G
F
V
V
N
P
K
R
I
L
A
E
N
I
D
E
I
W
N
F
I
Q
E
V
G
Q
E
R
E
N
L
P
Y
D
I
D
G
V
V
I
K
V
N
D
L
A
S
Q
E
E
L
G
F
T
V
K
A
P
K
W
A
V
A
Y
K
F
P
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------