@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA1649: (2016-01-31 )
MSKLLSGQVALVTGGAAGIGRATALAFAAAGVKVVVADLDSAGGEGTVEAIRQAGGEALFIRCDVTRDAEVKALVEGCAAAYGRLDYAFNNAGIEIEQGKLADGNEAEFDAIMAVNVKGVWLCMKHQIPLMLAQGGGAIVNTASVAGLGAAPKMSIYAASKHAVIGLTKSAAIEYAKKGIRVNAVCPAVIDTDMFRRAYEADPRKAEFAAAMHPLGRVGRVEEIAAAVLYLCCDNAGFTTGIALPVDGGATAI
Atome Classification :
(39 SA)
.........10........20........30........40........50.-..-.--....60-.........70........80........90...--....--.100...---------...-.110.......120.......130..-.....140..-...-----..150.......160.......170.......180.....-..190..-.....200--.----.--------....--...210---........220.......230.......240.......250.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSKLLSG
Q
V
A
L
V
TGGAAGI
G
R
A
T
A
L
A
F
A
AAG
V
K
V
V
V
A
DLDSAGGE
G
T
V
E
A
I
R
-
Q
A-G--G
E
A
L
F
--
I
R
CDVTR
D
A
E
V
K
A
L
V
E
G
C
A
A
A
YGR
L
D
Y
A
FNNAG
I
--
E
I
EQ--GKLADGN---------EAE-
F
D
A
I
M
A
V
NV
K
G
V
W
L
C
MKHQI
P
L
M
L
AQ-GG
G
A
I
V
N
T
A
S
-VAG-----LGAA
P
K
M
S
I
Y
AASK
H
A
V
I
GL
T
K
S
A
A
I
E
Y
A
K
KG
I
R
V
NAVC
P
-
A
VI
D
T
D
M
-
F
R
R
A
YE----A----D--------P
R
K
A
--
E
F
A
A
A
----MHPLGRVG
R
V
E
E
I
A
A
A
V
L
Y
L
CCDNAGFTT
G
I
A
L
PVDGGATAI
24
PsiBlast_CBE
91.16
39%
-111
- C1 -
1IY8
2
LVR_LEIAQ
E:
[11-265]
----
F
T
D
R
V
V
L
I
T
G
G
G
S
G
L
G
R
A
T
A
V
R
L
A
A
E
G
A
K
L
S
L
V
D
V
S
S
E
G
L
E
A
S
K
A
A
V
L
-
E
T
-
A
PD
A
E
V
L
T
--
T
V
A
D
V
S
D
E
A
Q
V
E
A
Y
V
T
A
T
T
E
R
F
G
R
I
D
G
F
F
N
N
A
G
I
--
E
G
K
Q
--
N
P
T
E
S
F
T
---------
A
A
E
-
F
D
K
V
V
S
I
N
L
R
G
V
F
L
G
L
E
K
V
L
K
I
M
R
E
Q
-
G
S
G
M
V
V
N
T
A
S
-
V
G
G
-----
I
R
G
I
G
N
Q
S
G
Y
A
A
A
K
H
G
V
V
G
L
T
R
N
S
A
V
E
Y
G
R
Y
G
I
R
I
N
A
I
A
P
-
G
A
I
W
T
P
M
-
V
E
N
S
M
K
----
Q
LDPE
N
--------
P
R
K
A
AE
E
F
-
I
Q
----
V
N
P
S
K
R
Y
G
E
A
P
E
I
A
A
V
V
A
F
L
L
S
D
D
A
S
Y
V
N
A
T
V
V
P
I
D
G
G
Q
S
A
A
22
PsiBlast_CBE
90.71
39%
-111
- C1 -
1IY8
2
LVR_LEIAQ
G:
[11-265]
----
F
T
D
R
V
V
L
I
T
G
G
G
S
G
L
G
R
A
T
A
V
R
L
A
A
E
G
A
K
L
S
L
V
D
V
S
S
E
G
L
E
A
S
K
A
A
V
L
-
E
T
-
A
PD
A
E
V
L
T
--
T
V
A
D
V
S
D
E
A
Q
V
E
A
Y
V
T
A
T
T
E
R
F
G
R
I
D
G
F
F
N
N
A
G
I
--
E
G
K
Q
--
N
P
T
E
S
F
T
---------
A
A
E
-
F
D
K
V
V
S
I
N
L
R
G
V
F
L
G
L
E
K
V
L
K
I
M
R
E
Q
-
G
S
G
M
V
V
N
T
A
S
-
V
G
G
-----
I
R
G
I
G
N
Q
S
G
Y
A
A
A
K
H
G
V
V
G
L
T
R
N
S
A
V
E
Y
G
R
Y
G
I
R
I
N
A
I
A
P
-
G
A
I
W
T
P
M
-
V
E
N
S
M
K
----
Q
LDPE
N
--------
P
R
K
A
AE
E
F
-
I
Q
----
V
N
P
S
K
R
Y
G
E
A
P
E
I
A
A
V
V
A
F
L
L
S
D
D
A
S
Y
V
N
A
T
V
V
P
I
D
G
G
Q
S
A
A
46
PsiBlast_CBE
90.20
40%
-111
- C1 -
2CFC
2
HCDR_XANP2
B:
[3-250]
-------
R
V
A
I
V
T
G
A
S
S
G
N
G
L
A
I
A
T
R
F
L
A
R
G
D
R
V
A
A
L
D
L
S
A
E
T
L
E
E
T
A
R
T
H
W
-
H
A
Y
A
--
D
K
V
L
R
--
V
R
A
D
V
A
D
E
G
D
V
N
A
A
I
A
A
T
M
E
Q
F
G
A
I
D
V
L
V
N
N
A
G
I
TG
N
S
E
A
--
G
V
L
H
T
T
P
---------
V
E
Q
-
F
D
K
V
M
A
V
N
V
R
G
I
F
L
G
C
R
A
V
L
P
H
M
L
L
Q
-
G
A
G
V
I
V
N
I
A
S
-
V
A
S
-----
L
V
A
F
P
G
R
S
A
Y
T
T
S
K
G
A
V
L
Q
L
T
K
S
V
A
V
D
Y
A
G
S
G
I
R
C
N
A
V
C
P
-
G
M
I
E
T
P
M
-
T
Q
W
R
L
D
---------
Q
--------
P
E
L
R
--
D
Q
V
L
A
----
R
I
P
Q
K
E
I
G
T
A
A
Q
V
A
D
A
V
M
F
L
A
G
E
D
A
T
Y
V
N
G
A
A
L
V
M
D
G
A
Y
T
A
I
45
PsiBlast_CBE
90.14
40%
-111
- C1 -
2CFC
2
HCDR_XANP2
C:
[3-250]
-------
R
V
A
I
V
T
G
A
S
S
G
N
G
L
A
I
A
T
R
F
L
A
R
G
D
R
V
A
A
L
D
L
S
A
E
T
L
E
E
T
A
R
T
H
W
-
H
A
Y
A
--
D
K
V
L
R
--
V
R
A
D
V
A
D
E
G
D
V
N
A
A
I
A
A
T
M
E
Q
F
G
A
I
D
V
L
V
N
N
A
G
I
TG
N
S
E
A
--
G
V
L
H
T
T
P
---------
V
E
Q
-
F
D
K
V
M
A
V
N
V
R
G
I
F
L
G
C
R
A
V
L
P
H
M
L
L
Q
-
G
A
G
V
I
V
N
I
A
S
-
V
A
S
-----
L
V
A
F
P
G
R
S
A
Y
T
T
S
K
G
A
V
L
Q
L
T
K
S
V
A
V
D
Y
A
G
S
G
I
R
C
N
A
V
C
P
-
G
M
I
E
T
P
M
-
T
Q
W
R
L
D
---------
Q
--------
P
E
L
R
--
D
Q
V
L
A
----
R
I
P
Q
K
E
I
G
T
A
A
Q
V
A
D
A
V
M
F
L
A
G
E
D
A
T
Y
V
N
G
A
A
L
V
M
D
G
A
Y
T
A
I
25
PsiBlast_CBE
90.00
39%
-112
- C1 -
1IY8
2
LVR_LEIAQ
D:
[11-265]
----
F
T
D
R
V
V
L
I
T
G
G
G
S
G
L
G
R
A
T
A
V
R
L
A
A
E
G
A
K
L
S
L
V
D
V
S
S
E
G
L
E
A
S
K
A
A
V
L
-
E
T
-
A
PD
A
E
V
L
T
--
T
V
A
D
V
S
D
E
A
Q
V
E
A
Y
V
T
A
T
T
E
R
F
G
R
I
D
G
F
F
N
N
A
G
I
--
E
G
K
Q
--
N
P
T
E
S
F
T
---------
A
A
E
-
F
D
K
V
V
S
I
N
L
R
G
V
F
L
G
L
E
K
V
L
K
I
M
R
E
Q
-
G
S
G
M
V
V
N
T
A
S
-
V
G
G
-----
I
R
G
I
G
N
Q
S
G
Y
A
A
A
K
H
G
V
V
G
L
T
R
N
S
A
V
E
Y
G
R
Y
G
I
R
I
N
A
I
A
P
-
G
A
I
W
T
P
M
-
V
E
N
S
M
K
----
Q
LDPE
N
--------
P
R
K
A
AE
E
F
-
I
Q
----
V
N
P
S
K
R
Y
G
E
A
P
E
I
A
A
V
V
A
F
L
L
S
D
D
A
S
Y
V
N
A
T
V
V
P
I
D
G
G
Q
S
A
A
44
PsiBlast_CBE
89.92
40%
-112
- C1 -
2CFC
2
HCDR_XANP2
D:
[3-250]
-------
R
V
A
I
V
T
G
A
S
S
G
N
G
L
A
I
A
T
R
F
L
A
R
G
D
R
V
A
A
L
D
L
S
A
E
T
L
E
E
T
A
R
T
H
W
-
H
A
Y
A
--
D
K
V
L
R
--
V
R
A
D
V
A
D
E
G
D
V
N
A
A
I
A
A
T
M
E
Q
F
G
A
I
D
V
L
V
N
N
A
G
I
TG
N
S
E
A
--
G
V
L
H
T
T
P
---------
V
E
Q
-
F
D
K
V
M
A
V
N
V
R
G
I
F
L
G
C
R
A
V
L
P
H
M
L
L
Q
-
G
A
G
V
I
V
N
I
A
S
-
V
A
S
-----
L
V
A
F
P
G
R
S
A
Y
T
T
S
K
G
A
V
L
Q
L
T
K
S
V
A
V
D
Y
A
G
S
G
I
R
C
N
A
V
C
P
-
G
M
I
E
T
P
M
-
T
Q
W
R
L
D
---------
Q
--------
P
E
L
R
--
D
Q
V
L
A
----
R
I
P
Q
K
E
I
G
T
A
A
Q
V
A
D
A
V
M
F
L
A
G
E
D
A
T
Y
V
N
G
A
A
L
V
M
D
G
A
Y
T
A
I
1
PsiBlast_PDB
89.58
39%
-109
- C1 -
1IY8
2
LVR_LEIAQ
A:
[11-265]
----
F
T
D
R
V
V
L
I
T
G
G
G
S
G
L
G
R
A
T
A
V
R
L
A
A
E
G
A
K
L
S
L
V
D
V
S
S
E
G
L
E
A
S
K
A
A
V
L
-
E
T
-
A
PD
A
E
V
L
T
--
T
V
A
D
V
S
D
E
A
Q
V
E
A
Y
V
T
A
T
T
E
R
F
G
R
I
D
G
F
F
N
N
A
G
I
--
E
G
K
Q
--
N
P
T
E
S
F
T
---------
A
A
E
-
F
D
K
V
V
S
I
N
L
R
G
V
F
L
G
L
E
K
V
L
K
I
M
R
E
Q
-
G
S
G
M
V
V
N
T
A
S
-
V
G
G
-----
I
R
G
I
G
N
Q
S
G
Y
A
A
A
K
H
G
V
V
G
L
T
R
N
S
A
V
E
Y
G
R
Y
G
I
R
I
N
A
I
A
P
-
G
A
I
W
T
P
M
-
V
E
N
S
M
K
----
Q
L
DPE
N
--------
P
R
K
A
A
E
E
F
-
I
Q
----
V
N
P
S
K
R
Y
G
E
A
P
E
I
A
A
V
V
A
F
L
L
S
D
D
A
S
Y
V
N
A
T
V
V
P
I
D
G
G
Q
S
A
A
16
PsiBlast_PDB
89.50
40%
-111
- C1 -
2CFC
2
HCDR_XANP2
A:
[3-250]
-------
R
V
A
I
V
T
G
A
S
S
G
N
G
L
A
I
A
T
R
F
L
A
R
G
D
R
V
A
A
L
D
L
S
A
E
T
L
E
E
T
A
R
T
H
W
-
H
A
Y
A
--
D
K
V
L
R
--
V
R
A
D
V
A
D
E
G
D
V
N
A
A
I
A
A
T
M
E
Q
F
G
A
I
D
V
L
V
N
N
A
G
I
TG
N
S
E
A
--
G
V
L
H
T
T
P
---------
V
E
Q
-
F
D
K
V
M
A
V
N
V
R
G
I
F
L
G
C
R
A
V
L
P
H
M
L
L
Q
-
G
A
G
V
I
V
N
I
A
S
-
V
A
S
-----
L
V
A
F
P
G
R
S
A
Y
T
T
S
K
G
A
V
L
Q
L
T
K
S
V
A
V
D
Y
A
G
S
G
I
R
C
N
A
V
C
P
-
G
M
I
E
T
P
M
-
T
Q
W
R
L
D
---------
Q
--------
P
E
L
R
--
D
Q
V
L
A
----
R
I
P
Q
K
E
I
G
T
A
A
Q
V
A
D
A
V
M
F
L
A
G
E
D
A
T
Y
V
N
G
A
A
L
V
M
D
G
A
Y
T
A
I
26
PsiBlast_CBE
89.17
39%
-110
- C1 -
1IY8
2
LVR_LEIAQ
C:
[11-265]
----
F
T
D
R
V
V
L
I
T
G
G
G
S
G
L
G
R
A
T
A
V
R
L
A
A
E
G
A
K
L
S
L
V
D
V
S
S
E
G
L
E
A
S
K
A
A
V
L
-
E
T
-
A
PD
A
E
V
L
T
--
T
V
A
D
V
S
D
E
A
Q
V
E
A
Y
V
T
A
T
T
E
R
F
G
R
I
D
G
F
F
N
N
A
G
I
--
E
G
K
Q
--
N
P
T
E
S
F
T
---------
A
A
E
-
F
D
K
V
V
S
I
N
L
R
G
V
F
L
G
L
E
K
V
L
K
I
M
R
E
Q
-
G
S
G
M
V
V
N
T
A
S
-
V
G
G
-----
I
R
G
I
G
N
Q
S
G
Y
A
A
A
K
H
G
V
V
G
L
T
R
N
S
A
V
E
Y
G
R
Y
G
I
R
I
N
A
I
A
P
-
G
A
I
W
T
P
M
-
V
E
N
S
M
K
----
Q
LDPE
N
--------
P
R
K
A
AE
E
F
-
I
Q
----
V
N
P
S
K
R
Y
G
E
A
P
E
I
A
A
V
V
A
F
L
L
S
D
D
A
S
Y
V
N
A
T
V
V
P
I
D
G
G
Q
S
A
A
21
PsiBlast_CBE
89.06
39%
-110
- C1 -
1IY8
2
LVR_LEIAQ
H:
[11-265]
----
F
T
D
R
V
V
L
I
T
G
G
G
S
G
L
G
R
A
T
A
V
R
L
A
A
E
G
A
K
L
S
L
V
D
V
S
S
E
G
L
E
A
S
K
A
A
V
L
-
E
T
-
A
PD
A
E
V
L
T
--
T
V
A
D
V
S
D
E
A
Q
V
E
A
Y
V
T
A
T
T
E
R
F
G
R
I
D
G
F
F
N
N
A
G
I
--
E
G
K
Q
--
N
P
T
E
S
F
T
---------
A
A
E
-
F
D
K
V
V
S
I
N
L
R
G
V
F
L
G
L
E
K
V
L
K
I
M
R
E
Q
-
G
S
G
M
V
V
N
T
A
S
-
V
G
G
-----
I
R
G
I
G
N
Q
S
G
Y
A
A
A
K
H
G
V
V
G
L
T
R
N
S
A
V
E
Y
G
R
Y
G
I
R
I
N
A
I
A
P
-
G
A
I
W
T
P
M
-
V
E
N
S
M
K
----
Q
LDPE
N
--------
P
R
K
A
AE
E
F
-
I
Q
----
V
N
P
S
K
R
Y
G
E
A
P
E
I
A
A
V
V
A
F
L
L
S
D
D
A
S
Y
V
N
A
T
V
V
P
I
D
G
G
Q
S
A
A
27
PsiBlast_CBE
89.02
39%
-111
- C1 -
1IY8
2
LVR_LEIAQ
B:
[11-265]
----
F
T
D
R
V
V
L
I
T
G
G
G
S
G
L
G
R
A
T
A
V
R
L
A
A
E
G
A
K
L
S
L
V
D
V
S
S
E
G
L
E
A
S
K
A
A
V
L
-
E
T
-
A
PD
A
E
V
L
T
--
T
V
A
D
V
S
D
E
A
Q
V
E
A
Y
V
T
A
T
T
E
R
F
G
R
I
D
G
F
F
N
N
A
G
I
--
E
G
K
Q
--
N
P
T
E
S
F
T
---------
A
A
E
-
F
D
K
V
V
S
I
N
L
R
G
V
F
L
G
L
E
K
V
L
K
I
M
R
E
Q
-
G
S
G
M
V
V
N
T
A
S
-
V
G
G
-----
I
R
G
I
G
N
Q
S
G
Y
A
A
A
K
H
G
V
V
G
L
T
R
N
S
A
V
E
Y
G
R
Y
G
I
R
I
N
A
I
A
P
-
G
A
I
W
T
P
M
-
V
E
N
S
M
K
----
Q
LDPE
N
--------
P
R
K
A
AE
E
F
-
I
Q
----
V
N
P
S
K
R
Y
G
E
A
P
E
I
A
A
V
V
A
F
L
L
S
D
D
A
S
Y
V
N
A
T
V
V
P
I
D
G
G
Q
S
A
A
40
PsiBlast_CBE
88.82
42%
-118
- C1 -
4NBW
1
?
B:
[6-252]
-------
R
V
A
I
I
T
G
A
A
N
G
I
G
R
A
T
A
L
E
F
A
Q
A
G
Y
H
V
V
A
W
D
L
A
E
E
A
G
A
A
L
I
A
E
I
A
-
D
A
-
G
--
G
S
A
D
F
--
A
R
V
D
V
S
A
A
E
S
V
E
A
A
V
A
E
I
I
A
E
H
G
R
V
D
V
L
V
N
N
A
G
I
---
L
H
D
--
G
Q
L
V
K
V
K
GGEVVKKMA
E
A
Q
-
F
D
A
V
I
S
V
N
L
K
G
V
F
L
C
T
Q
A
V
A
P
H
M
I
A
A
-
K
Y
G
R
I
L
N
A
S
S
-
V
V
G
-----
L
Y
G
N
F
G
Q
T
N
Y
V
A
A
K
S
G
V
I
G
M
T
K
V
W
A
R
E
L
G
R
Y
G
I
T
V
N
A
I
A
P
-
G
F
I
A
T
E
M
-
V
Q
Q
M
P
E
-------------------
R
V
L
--
E
A
M
V
A
----
R
T
P
V
G
R
I
G
D
P
V
D
I
A
R
A
Y
L
F
L
A
S
E
E
S
G
F
I
S
G
T
T
L
S
V
D
G
G
M
V
V
G
112
HHSearch
88.81
39%
-110
- C1 -
2CFC
2
HCDR_XANP2
A:
[1-250]
-----
M
S
R
V
A
I
V
T
G
A
S
S
G
N
G
L
A
I
A
T
R
F
L
A
R
G
D
R
V
A
A
L
D
L
S
A
E
T
L
E
E
T
A
R
T
H
W
H
A
Y
-
A
--
D
K
V
L
R
--
V
R
A
D
V
A
D
E
G
D
V
N
A
A
I
A
A
T
M
E
Q
F
G
A
I
D
V
L
V
N
N
A
G
I
--
T
G
N
S
EA
G
V
L
H
T
T
P
---------
V
E
Q
-
F
D
K
V
M
A
V
N
V
R
G
I
F
L
G
C
R
A
V
L
P
H
M
L
L
Q
-
G
A
G
V
I
V
N
I
A
S
-
V
A
S
-----
L
V
A
F
P
G
R
S
A
Y
T
T
S
K
G
A
V
L
Q
L
T
K
S
V
A
V
D
Y
A
G
S
G
I
R
C
N
A
V
C
P
-
G
M
I
E
T
P
M
-
T
Q
W
R
L
D
----
Q
----
P
---------
E
L
R
--
D
Q
V
L
A
----
R
I
P
Q
K
E
I
G
T
A
A
Q
V
A
D
A
V
M
F
L
A
G
E
D
A
T
Y
V
N
G
A
A
L
V
M
D
G
A
Y
T
A
I
23
PsiBlast_CBE
88.78
39%
-109
- C1 -
1IY8
2
LVR_LEIAQ
F:
[11-265]
----
F
T
D
R
V
V
L
I
T
G
G
G
S
G
L
G
R
A
T
A
V
R
L
A
A
E
G
A
K
L
S
L
V
D
V
S
S
E
G
L
E
A
S
K
A
A
V
L
-
E
T
-
A
PD
A
E
V
L
T
--
T
V
A
D
V
S
D
E
A
Q
V
E
A
Y
V
T
A
T
T
E
R
F
G
R
I
D
G
F
F
N
N
A
G
I
--
E
G
K
Q
--
N
P
T
E
S
F
T
---------
A
A
E
-
F
D
K
V
V
S
I
N
L
R
G
V
F
L
G
L
E
K
V
L
K
I
M
R
E
Q
-
G
S
G
M
V
V
N
T
A
S
-
V
G
G
-----
I
R
G
I
G
N
Q
S
G
Y
A
A
A
K
H
G
V
V
G
L
T
R
N
S
A
V
E
Y
G
R
Y
G
I
R
I
N
A
I
A
P
-
G
A
I
W
T
P
M
-
V
E
N
S
M
K
----
Q
LDPE
N
--------
P
R
K
A
AE
E
F
-
I
Q
----
V
N
P
S
K
R
Y
G
E
A
P
E
I
A
A
V
V
A
F
L
L
S
D
D
A
S
Y
V
N
A
T
V
V
P
I
D
G
G
Q
S
A
A
38
PsiBlast_CBE
87.39
42%
-112
- C1 -
4NBW
1
?
D:
[6-252]
-------
R
V
A
I
I
T
G
A
A
N
G
I
G
R
A
T
A
L
E
F
A
Q
A
G
Y
H
V
V
A
W
D
L
A
E
E
A
G
A
A
L
I
A
E
I
A
-
D
A
-
G
--
G
S
A
D
F
--
A
R
V
D
V
S
A
A
E
S
V
E
A
A
V
A
E
I
I
A
E
H
G
R
V
D
V
L
V
N
N
A
G
I
---
L
H
D
--
G
Q
L
V
K
V
K
GGEVVKKMA
E
A
Q
-
F
D
A
V
I
S
V
N
L
K
G
V
F
L
C
T
Q
A
V
A
P
H
M
I
A
A
-
K
Y
G
R
I
L
N
A
S
S
-
V
V
G
-----
L
Y
G
N
F
G
Q
T
N
Y
V
A
A
K
S
G
V
I
G
M
T
K
V
W
A
R
E
L
G
R
Y
G
I
T
V
N
A
I
A
P
-
G
F
I
A
T
E
M
-
V
Q
Q
M
P
E
-------------------
R
V
L
--
E
A
M
V
A
----
R
T
P
V
G
R
I
G
D
P
V
D
I
A
R
A
Y
L
F
L
A
S
E
E
S
G
F
I
S
G
T
T
L
S
V
D
G
G
M
V
V
G
39
PsiBlast_CBE
87.36
42%
-112
- C1 -
4NBW
1
?
C:
[6-252]
-------
R
V
A
I
I
T
G
A
A
N
G
I
G
R
A
T
A
L
E
F
A
Q
A
G
Y
H
V
V
A
W
D
L
A
E
E
A
G
A
A
L
I
A
E
I
A
-
D
A
-
G
--
G
S
A
D
F
--
A
R
V
D
V
S
A
A
E
S
V
E
A
A
V
A
E
I
I
A
E
H
G
R
V
D
V
L
V
N
N
A
G
I
---
L
H
D
--
G
Q
L
V
K
V
K
GGEVVKKMA
E
A
Q
-
F
D
A
V
I
S
V
N
L
K
G
V
F
L
C
T
Q
A
V
A
P
H
M
I
A
A
-
K
Y
G
R
I
L
N
A
S
S
-
V
V
G
-----
L
Y
G
N
F
G
Q
T
N
Y
V
A
A
K
S
G
V
I
G
M
T
K
V
W
A
R
E
L
G
R
Y
G
I
T
V
N
A
I
A
P
-
G
F
I
A
T
E
M
-
V
Q
Q
M
P
E
-------------------
R
V
L
--
E
A
M
V
A
----
R
T
P
V
G
R
I
G
D
P
V
D
I
A
R
A
Y
L
F
L
A
S
E
E
S
G
F
I
S
G
T
T
L
S
V
D
G
G
M
V
V
G
4
PsiBlast_PDB
87.16
43%
-124
- C1 -
4NI5
-
?
A:
[11-253]
----
F
K
D
K
V
V
I
V
T
G
G
A
S
G
I
G
E
A
T
A
R
A
F
I
R
E
G
A
K
V
V
I
A
D
F
-
S
D
-------------------
A
L
F
--
I
K
T
D
V
A
D
T
R
A
V
Q
A
L
I
A
R
T
V
E
N
Y
G
R
L
D
I
M
F
A
N
A
G
I
--
A
A
D
---
A
P
I
D
E
L
D
---------
E
A
A
-
W
Q
K
T
I
D
I
N
L
T
G
V
Y
L
C
D
K
Y
A
I
D
Q
M
R
S
Q
-
G
G
G
V
I
V
N
C
G
S
-
I
H
S
-----
H
V
G
K
S
G
V
T
A
Y
A
A
A
K
G
G
V
K
L
L
T
Q
T
L
A
I
D
Y
G
P
Q
N
I
R
V
N
A
V
C
P
-
G
Y
I
D
T
-------
P
D
-------------------
D
K
K
--
Q
A
L
V
A
----
L
H
P
M
G
R
L
G
R
A
E
E
V
A
N
A
V
L
F
L
A
S
D
E
A
S
F
V
N
G
A
S
L
L
V
D
G
G
Y
T
A
Q
64
PsiBlast_CBE
86.53
40%
-106
- C1 -
3TOX
1
?
F:
[4-254]
-
S
R
L
-
E
G
K
I
A
I
V
T
G
A
S
S
G
I
G
R
A
A
A
L
L
F
A
R
E
G
A
K
V
V
V
T
A
R
N
G
N
A
L
A
E
L
T
D
E
I
A
-
G
G
-
G
--
G
E
A
A
A
--
L
A
G
D
V
G
D
E
A
L
H
E
A
L
V
E
L
A
V
R
R
F
G
G
L
D
T
A
F
N
N
A
G
A
--
L
G
A
M
--
G
E
I
S
S
L
S
---------
V
E
G
-
W
R
E
T
L
D
T
N
L
T
S
A
F
L
A
A
K
Y
Q
V
P
A
I
A
A
L
-
G
G
G
S
L
T
F
T
S
S
-
F
V
G
HTAGF
A
G
V
A
P
----
Y
A
A
S
K
A
G
L
I
G
L
V
Q
A
L
A
V
E
L
G
A
R
G
I
R
V
N
A
L
L
P
-
G
G
T
D
T
P
A
N
F
A
N
---------------------
P
E
T
R
--
G
F
V
E
G
----
L
H
A
L
K
R
I
A
R
P
E
E
I
A
E
A
A
L
Y
L
A
S
D
G
A
S
F
V
T
G
A
A
L
L
A
D
G
G
A
S
V
T
63
PsiBlast_CBE
86.46
40%
-104
- C1 -
3TOX
1
?
G:
[4-254]
-
S
R
L
-
E
G
K
I
A
I
V
T
G
A
S
S
G
I
G
R
A
A
A
L
L
F
A
R
E
G
A
K
V
V
V
T
A
R
N
G
N
A
L
A
E
L
T
D
E
I
A
-
G
G
-
G
--
G
E
A
A
A
--
L
A
G
D
V
G
D
E
A
L
H
E
A
L
V
E
L
A
V
R
R
F
G
G
L
D
T
A
F
N
N
A
G
A
--
L
G
A
M
--
G
E
I
S
S
L
S
---------
V
E
G
-
W
R
E
T
L
D
T
N
L
T
S
A
F
L
A
A
K
Y
Q
V
P
A
I
A
A
L
-
G
G
G
S
L
T
F
T
S
S
-
F
V
G
HTAGF
A
G
V
A
P
----
Y
A
A
S
K
A
G
L
I
G
L
V
Q
A
L
A
V
E
L
G
A
R
G
I
R
V
N
A
L
L
P
-
G
G
T
D
T
P
A
N
F
A
N
L
-----------
A
--------
P
E
T
R
--
G
F
V
E
G
----
L
H
A
L
K
R
I
A
R
P
E
E
I
A
E
A
A
L
Y
L
A
S
D
G
A
S
F
V
T
G
A
A
L
L
A
D
G
G
A
S
V
T
131
HHSearch
85.79
37%
-109
- C1 -
3WDS
4
?
A:
[8-262]
--
F
D
L
S
G
R
K
A
I
V
T
G
G
S
K
G
I
G
A
A
I
A
R
A
L
D
K
A
G
A
T
V
A
I
A
D
L
D
V
M
A
A
Q
A
V
V
A
G
L
E
-------
N
G
G
F
A
--
V
E
V
D
V
T
K
R
A
S
V
D
A
A
M
Q
K
A
I
D
A
L
G
G
F
D
L
L
C
A
N
A
G
V
--
S
T
M
R
---
P
A
V
D
I
T
---------
D
E
E
-
W
D
F
N
F
D
V
N
A
R
G
V
F
L
A
N
Q
I
A
C
R
H
F
L
A
S
N
T
K
G
V
I
V
N
T
A
S
-
L
A
A
-----
K
V
G
A
P
L
L
A
H
Y
S
A
S
K
F
A
V
F
G
W
T
Q
A
L
A
R
E
M
A
P
K
N
I
R
V
N
C
V
C
P
-
G
F
V
K
T
A
M
-
Q
E
R
E
I
I
----
W
----
E
A
E
L
R
GMT
P
E
A
V
R
--
A
E
Y
V
S
----
L
T
P
L
G
R
I
E
E
P
E
D
V
A
D
V
V
V
F
L
A
S
D
A
A
R
F
M
T
G
Q
G
I
N
V
T
G
G
V
R
M
D
29
PsiBlast_CBE
85.12
42%
-112
- C1 -
4URE
5
?
B:
[2-244]
---
L
L
E
G
K
T
A
L
V
T
G
A
G
N
G
I
G
R
T
I
A
L
T
Y
A
A
E
G
A
N
V
V
V
S
D
I
S
D
E
W
G
R
E
T
L
A
L
I
E
-
G
K
-
G
--
G
K
A
V
F
--
Q
H
A
D
T
A
H
P
E
D
H
D
E
L
I
A
A
A
K
R
A
F
G
R
L
D
I
A
C
N
N
A
G
I
--
S
G
E
F
--
T
P
T
A
E
T
T
---------
D
A
Q
-
W
Q
R
V
I
G
I
N
L
S
G
V
F
Y
G
V
R
A
Q
I
R
A
M
L
E
T
-
G
G
G
A
I
V
N
I
S
S
-
I
A
G
-----
Q
I
G
I
E
G
I
T
P
Y
T
A
A
K
H
G
V
V
G
L
T
K
T
V
A
W
E
Y
G
S
K
G
I
R
I
N
S
V
G
P
-
A
F
I
N
T
T
L
-
V
Q
N
V
P
L
----
E
----
T
--------
R
R
Q
L
--
E
---
Q
----
M
H
A
L
R
R
L
G
E
T
E
E
V
A
N
L
V
A
W
L
S
S
D
K
A
S
F
V
T
G
S
Y
Y
A
V
D
G
G
Y
L
A
R
31
PsiBlast_CBE
84.68
37%
-119
- C1 -
4WEC
5
?
C:
[26-272]
--
Q
R
L
A
G
K
V
A
V
I
T
G
G
A
S
G
I
G
L
A
T
G
R
R
L
R
A
E
G
A
T
V
V
V
G
D
I
D
P
T
T
G
K
A
A
A
D
E
L
---------
E
G
L
F
--
V
P
V
D
V
S
E
Q
E
A
V
D
N
L
F
D
T
A
A
S
T
F
G
R
V
D
I
A
F
N
N
A
G
I
--
S
P
P
E
--
D
D
L
I
E
N
T
---------
D
L
P
A
W
Q
R
V
Q
D
I
N
L
K
S
V
Y
L
S
C
R
A
A
L
R
H
M
V
P
A
-
G
K
G
S
I
I
N
T
A
S
F
V
A
V
-----
M
G
S
A
T
S
Q
I
S
Y
T
A
S
K
G
G
V
L
A
M
S
R
E
L
G
V
Q
Y
A
R
Q
G
I
R
V
N
A
L
C
P
-
G
P
V
N
T
P
L
-
L
Q
E
L
F
A
----
K
----
D
--------
P
E
R
A
--
A
R
R
L
V
----
H
I
P
L
G
R
F
A
E
P
E
E
L
A
A
A
V
A
F
L
A
S
D
D
A
S
F
I
T
G
S
T
F
L
V
D
G
G
I
S
S
A
5
PsiBlast_PDB
84.22
37%
-118
- C1 -
4WEC
5
?
A:
[24-272]
L
T
Q
R
L
A
G
K
V
A
V
I
T
G
G
A
S
G
I
G
L
A
T
G
R
R
L
R
A
E
G
A
T
V
V
V
G
D
I
D
P
T
T
G
K
A
A
A
D
E
L
---------
E
G
L
F
--
V
P
V
D
V
S
E
Q
E
A
V
D
N
L
F
D
T
A
A
S
T
F
G
R
V
D
I
A
F
N
N
A
G
I
--
S
P
P
E
--
D
D
L
I
E
N
T
---------
D
L
P
A
W
Q
R
V
Q
D
I
N
L
K
S
V
Y
L
S
C
R
A
A
L
R
H
M
V
P
A
-
G
K
G
S
I
I
N
T
A
S
F
V
A
V
-----
M
G
S
A
T
S
Q
I
S
Y
T
A
S
K
G
G
V
L
A
M
S
R
E
L
G
V
Q
Y
A
R
Q
G
I
R
V
N
A
L
C
P
-
G
P
V
N
T
P
L
-
L
Q
E
L
F
A
----
K
----
D
--------
P
E
R
A
--
A
R
R
L
V
----
H
I
P
L
G
R
F
A
E
P
E
E
L
A
A
A
V
A
F
L
A
S
D
D
A
S
F
I
T
G
S
T
F
L
V
D
G
G
I
S
S
A
32
PsiBlast_CBE
84.01
37%
-117
- C1 -
4WEC
5
?
B:
[25-272]
-
T
Q
R
L
A
G
K
V
A
V
I
T
G
G
A
S
G
I
G
L
A
T
G
R
R
L
R
A
E
G
A
T
V
V
V
G
D
I
D
P
T
T
G
K
A
A
A
D
E
L
---------
E
G
L
F
--
V
P
V
D
V
S
E
Q
E
A
V
D
N
L
F
D
T
A
A
S
T
F
G
R
V
D
I
A
F
N
N
A
G
I
--
S
P
P
E
--
D
D
L
I
E
N
T
---------
D
L
P
A
W
Q
R
V
Q
D
I
N
L
K
S
V
Y
L
S
C
R
A
A
L
R
H
M
V
P
A
-
G
K
G
S
I
I
N
T
A
S
F
V
A
V
-----
M
G
S
A
T
S
Q
I
S
Y
T
A
S
K
G
G
V
L
A
M
S
R
E
L
G
V
Q
Y
A
R
Q
G
I
R
V
N
A
L
C
P
-
G
P
V
N
T
P
L
-
L
Q
E
L
F
A
----
K
----
D
--------
P
E
R
A
--
A
R
R
L
V
----
H
I
P
L
G
R
F
A
E
P
E
E
L
A
A
A
V
A
F
L
A
S
D
D
A
S
F
I
T
G
S
T
F
L
V
D
G
G
I
S
S
A
37
PsiBlast_CBE
83.99
40%
-111
- C1 -
4NBU
2
?
B:
[8-247]
M
S
R
L
-
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
A
D
F
N
E
A
A
G
K
E
A
V
E
A
------
N
--
P
G
V
V
F
--
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
G
I
---
T
R
D
--
S
M
L
S
K
M
T
---------
V
D
Q
-
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
Q
-
G
K
G
K
I
I
N
T
S
S
-
V
T
G
-----
T
Y
G
N
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
G
I
N
V
N
A
V
A
P
-
G
F
T
E
T
A
M
----
V
A
E
----
V
----
P
--------
E
K
V
I
--
E
K
M
K
A
----
Q
V
P
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
I
M
M
-
36
PsiBlast_CBE
83.96
40%
-108
- C1 -
4NBU
1
?
C:
[9-247]
-
S
R
L
-
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
A
D
F
N
E
A
A
G
K
E
A
V
E
A
------
N
--
P
G
V
V
F
--
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
G
I
---
T
R
D
--
S
M
L
S
K
M
T
---------
V
D
Q
-
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
Q
-
G
K
G
K
I
I
N
T
S
S
-
V
T
G
-----
T
Y
G
N
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
G
I
N
V
N
A
V
A
P
-
G
F
T
E
T
A
M
----
V
A
E
----
V
----
P
--------
E
K
V
I
--
E
K
M
K
A
----
Q
V
P
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
I
M
M
-
30
PsiBlast_CBE
83.90
37%
-119
- C1 -
4WEC
5
?
D:
[24-272]
L
T
Q
R
L
A
G
K
V
A
V
I
T
G
G
A
S
G
I
G
L
A
T
G
R
R
L
R
A
E
G
A
T
V
V
V
G
D
I
D
P
T
T
G
K
A
A
A
D
E
L
---------
E
G
L
F
--
V
P
V
D
V
S
E
Q
E
A
V
D
N
L
F
D
T
A
A
S
T
F
G
R
V
D
I
A
F
N
N
A
G
I
--
S
P
P
E
--
D
D
L
I
E
N
T
---------
D
L
P
A
W
Q
R
V
Q
D
I
N
L
K
S
V
Y
L
S
C
R
A
A
L
R
H
M
V
P
A
-
G
K
G
S
I
I
N
T
A
S
F
V
A
V
-----
M
G
S
A
T
S
Q
I
S
Y
T
A
S
K
G
G
V
L
A
M
S
R
E
L
G
V
Q
Y
A
R
Q
G
I
R
V
N
A
L
C
P
-
G
P
V
N
T
P
L
-
L
Q
E
L
F
A
----
K
----
D
--------
P
E
R
A
--
A
R
R
L
V
----
H
I
P
L
G
R
F
A
E
P
E
E
L
A
A
A
V
A
F
L
A
S
D
D
A
S
F
I
T
G
S
T
F
L
V
D
G
G
I
S
S
A
13
PsiBlast_PDB
83.09
39%
-109
- C1 -
2DTE
1
?
A:
[6-247]
----
L
R
D
K
V
V
I
V
T
G
A
S
M
G
I
G
R
A
I
A
E
R
F
V
D
E
G
S
K
V
I
--
D
L
S
I
------------
H
D
-
P
--
G
E
A
K
Y
D
H
I
E
C
D
V
T
N
P
D
Q
V
K
A
S
I
D
H
I
F
K
E
Y
G
S
I
S
V
L
V
N
N
A
G
I
--
E
-
S
Y
--
G
K
I
E
S
M
S
---------
M
G
E
-
W
R
R
I
I
D
V
N
L
F
G
Y
Y
Y
A
S
K
F
A
I
P
Y
M
I
R
S
-
R
D
P
S
I
V
N
I
S
S
-
V
Q
A
-----
S
I
I
T
K
N
A
S
A
Y
V
T
S
K
H
A
V
I
G
L
T
K
S
I
A
L
D
Y
A
P
L
-
L
R
C
N
A
V
C
P
-
A
T
I
D
T
P
L
-
V
R
K
A
A
E
L
E
VG
S
----
D
--------
P
M
R
I
--
E
K
K
I
S
E
W
G
H
E
H
P
M
Q
R
I
G
K
P
Q
E
V
A
S
A
V
A
F
L
A
S
R
E
A
S
F
I
T
G
T
C
L
Y
V
D
G
G
L
S
I
R
35
PsiBlast_CBE
82.32
40%
-109
- C1 -
4NBU
2
?
D:
[9-247]
-
S
R
L
-
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
A
D
F
N
E
A
A
G
K
E
A
V
E
A
------
N
--
P
G
V
V
F
--
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
G
I
---
T
R
D
--
S
M
L
S
K
M
T
---------
V
D
Q
-
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
Q
-
G
K
G
K
I
I
N
T
S
S
-
V
T
G
-----
T
Y
G
N
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
G
I
N
V
N
A
V
A
P
-
G
F
T
E
T
A
M
----
V
A
E
----
V
----
P
--------
E
K
V
I
--
E
K
M
K
A
----
Q
V
P
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
I
M
M
-
9
PsiBlast_PDB
82.31
40%
-111
- C1 -
4NBU
1
?
A:
[9-247]
-
S
R
L
-
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
A
D
F
N
E
A
A
G
K
E
A
V
E
A
------
N
--
P
G
V
V
F
--
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
G
I
---
T
R
D
--
S
M
L
S
K
M
T
---------
V
D
Q
-
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
Q
-
G
K
G
K
I
I
N
T
S
S
-
V
T
G
-----
T
Y
G
N
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
G
I
N
V
N
A
V
A
P
-
G
F
T
E
T
A
M
----
V
A
E
----
V
----
P
--------
E
K
V
I
--
E
K
M
K
A
----
Q
V
P
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
I
M
M
-
42
PsiBlast_CBE
81.89
39%
-112
- C1 -
2DTE
1
?
B:
[6-247]
----
L
R
D
K
V
V
I
V
T
G
A
S
M
G
I
G
R
A
I
A
E
R
F
V
D
E
G
S
K
V
I
--
D
L
S
I
------------
H
D
-
P
--
G
E
A
K
Y
DH
I
E
C
D
V
T
N
P
D
Q
V
K
A
S
I
D
H
I
F
K
E
Y
G
S
I
S
V
L
V
N
N
A
G
I
--
E
-
S
Y
--
G
K
I
E
S
M
S
---------
M
G
E
-
W
R
R
I
I
D
V
N
L
F
G
Y
Y
Y
A
S
K
F
A
I
P
Y
M
I
R
S
-
R
D
P
S
I
V
N
I
S
S
-
V
Q
A
-----
S
I
I
T
K
N
A
S
A
Y
V
T
S
K
H
A
V
I
G
L
T
K
S
I
A
L
D
Y
A
P
L
-
L
R
C
N
A
V
C
P
-
A
T
I
D
T
P
L
-
V
R
K
A
A
E
LEVG
S
----
D
--------
P
M
R
I
--
E
K
K
I
S
EWGH
E
H
P
M
Q
R
I
G
K
P
Q
E
V
A
S
A
V
A
F
L
A
S
R
E
A
S
F
I
T
G
T
C
L
Y
V
D
G
G
L
S
I
R
88
PsiBlast_CBE
71.53
40%
-93
- C1 -
4ITU
2
?
A:
[45-269]
------------------------------
G
A
K
V
A
L
I
D
L
D
Q
G
L
A
E
R
S
A
A
M
L
S
-
T
G
-
G
--
A
V
A
K
G
--
F
G
A
D
V
T
K
A
A
D
I
T
A
A
I
T
S
A
E
Q
T
I
G
S
L
T
G
L
V
N
N
A
G
I
--
A
-
G
F
--
G
S
V
H
D
A
D
---------
A
A
A
-
W
D
R
I
M
A
V
N
V
T
G
T
F
L
A
S
K
A
A
L
A
G
M
L
E
R
-
H
K
G
T
I
V
N
F
G
S
-
V
A
G
-----
L
V
G
I
P
T
M
A
A
Y
C
A
A
K
G
A
I
V
N
L
T
R
Q
M
A
A
D
Y
S
G
R
G
V
R
V
N
A
V
C
P
G
T
V
T
S
T
G
M
-
G
Q
Q
L
L
G
----
S
----
D
TS------
P
E
V
Q
--
A
R
R
L
A
----
K
Y
P
I
G
R
F
G
T
P
E
D
I
A
E
A
V
I
F
L
L
S
D
Q
A
A
F
V
T
G
A
A
F
A
V
D
G
G
M
T
A
I
87
PsiBlast_CBE
70.56
40%
-95
- C1 -
4ITU
2
?
B:
[45-269]
------------------------------
G
A
K
V
A
L
I
D
L
D
Q
G
L
A
E
R
S
A
A
M
L
S
-
T
G
-
G
--
A
V
A
K
G
--
F
G
A
D
V
T
K
A
A
D
I
T
A
A
I
T
S
A
E
Q
T
I
G
S
L
T
G
L
V
N
N
A
G
I
--
A
-
G
F
--
G
S
V
H
D
A
D
---------
A
A
A
-
W
D
R
I
M
A
V
N
V
T
G
T
F
L
A
S
K
A
A
L
A
G
M
L
E
R
-
H
K
G
T
I
V
N
F
G
S
-
V
A
G
-----
L
V
G
I
P
T
M
A
A
Y
C
A
A
K
G
A
I
V
N
L
T
R
Q
M
A
A
D
Y
S
G
R
G
V
R
V
N
A
V
C
P
G
T
V
T
S
T
G
M
-
G
Q
Q
L
L
G
----------S-------
P
E
V
Q
--
A
R
R
L
A
----
K
Y
P
I
G
R
F
G
T
P
E
D
I
A
E
A
V
I
F
L
L
S
D
Q
A
A
F
V
T
G
A
A
F
A
V
D
G
G
M
T
A
I
90
PsiBlast_CBE
69.48
40%
-95
- C1 -
4GH5
2
?
C:
[45-269]
------------------------------
G
A
K
V
A
L
I
D
L
D
Q
G
L
A
E
R
S
A
A
M
L
S
-
T
G
-
G
--
A
V
A
K
G
--
F
G
A
D
V
T
K
A
A
D
I
T
A
A
I
T
S
A
E
Q
T
I
G
S
L
T
G
L
V
N
N
A
G
I
--
A
-
G
F
--
G
S
V
H
D
A
D
---------
A
A
A
-
W
D
R
I
M
A
V
N
V
T
G
T
F
L
A
S
K
A
A
L
A
G
M
L
E
R
-
H
K
G
T
I
V
N
F
G
S
-
V
A
G
-----
L
V
G
I
P
T
M
A
A
Y
C
A
A
K
G
A
I
V
N
L
T
R
Q
M
A
A
D
Y
S
G
R
G
V
R
V
N
A
V
C
P
G
T
V
T
S
T
G
M
-
G
Q
Q
L
L
--------------------
E
V
Q
--
A
R
R
L
A
----
K
Y
P
I
G
R
F
G
T
P
E
D
I
A
E
A
V
I
F
L
L
S
D
Q
A
A
F
V
T
G
A
A
F
A
V
D
G
G
M
T
A
I
92
PsiBlast_CBE
68.67
40%
-94
- C1 -
4GH5
2
?
A:
[45-269]
------------------------------
G
A
K
V
A
L
I
D
L
D
Q
G
L
A
E
R
S
A
A
M
L
S
-
T
G
-
G
--
A
V
A
K
G
--
F
G
A
D
V
T
K
A
A
D
I
T
A
A
I
T
S
A
E
Q
T
I
G
S
L
T
G
L
V
N
N
A
G
I
--
A
-
G
F
--
G
S
V
H
D
A
D
---------
A
A
A
-
W
D
R
I
M
A
V
N
V
T
G
T
F
L
A
S
K
A
A
L
A
G
M
L
E
R
-
H
K
G
T
I
V
N
F
G
S
-
V
A
G
-----
L
V
G
I
P
T
M
A
A
Y
C
A
A
K
G
A
I
V
N
L
T
R
Q
M
A
A
D
Y
S
G
R
G
V
R
V
N
A
V
C
P
G
T
V
T
S
T
G
M
-
G
Q
Q
L
L
-------------------
P
E
V
Q
--
A
R
R
L
A
----
K
Y
P
I
G
R
F
G
T
P
E
D
I
A
E
A
V
I
F
L
L
S
D
Q
A
A
F
V
T
G
A
A
F
A
V
D
G
G
M
T
A
I
86
PsiBlast_CBE
68.34
40%
-94
- C1 -
4ITU
2
?
C:
[45-269]
------------------------------
G
A
K
V
A
L
I
D
L
D
Q
G
L
A
E
R
S
A
A
M
L
S
-
T
G
-
G
--
A
V
A
K
G
--
F
G
A
D
V
T
K
A
A
D
I
T
A
A
I
T
S
A
E
Q
T
I
G
S
L
T
G
L
V
N
N
A
G
I
--
A
-
G
F
--
G
S
V
H
D
A
D
---------
A
A
A
-
W
D
R
I
M
A
V
N
V
T
G
T
F
L
A
S
K
A
A
L
A
G
M
L
E
R
-
H
K
G
T
I
V
N
F
G
S
-
V
A
G
-----
L
V
G
I
P
T
M
A
A
Y
C
A
A
K
G
A
I
V
N
L
T
R
Q
M
A
A
D
Y
S
G
R
G
V
R
V
N
A
V
C
P
G
T
V
T
S
T
G
M
-
G
Q
Q
L
L
---------------------
V
Q
--
A
R
R
L
A
----
K
Y
P
I
G
R
F
G
T
P
E
D
I
A
E
A
V
I
F
L
L
S
D
Q
A
A
F
V
T
G
A
A
F
A
V
D
G
G
M
T
A
I
85
PsiBlast_CBE
68.33
40%
-94
- C1 -
4ITU
2
?
D:
[45-269]
------------------------------
G
A
K
V
A
L
I
D
L
D
Q
G
L
A
E
R
S
A
A
M
L
S
-
T
G
-
G
--
A
V
A
K
G
--
F
G
A
D
V
T
K
A
A
D
I
T
A
A
I
T
S
A
E
Q
T
I
G
S
L
T
G
L
V
N
N
A
G
I
--
A
-
G
F
--
G
S
V
H
D
A
D
---------
A
A
A
-
W
D
R
I
M
A
V
N
V
T
G
T
F
L
A
S
K
A
A
L
A
G
M
L
E
R
-
H
K
G
T
I
V
N
F
G
S
-
V
A
G
-----
L
V
G
I
P
T
M
A
A
Y
C
A
A
K
G
A
I
V
N
L
T
R
Q
M
A
A
D
Y
S
G
R
G
V
R
V
N
A
V
C
P
G
T
V
T
S
T
G
M
-
G
Q
Q
L
L
G
------------------
P
E
V
Q
--
A
R
R
L
A
----
K
Y
P
I
G
R
F
G
T
P
E
D
I
A
E
A
V
I
F
L
L
S
D
Q
A
A
F
V
T
G
A
A
F
A
V
D
G
G
M
T
A
I
91
PsiBlast_CBE
68.21
40%
-95
- C1 -
4GH5
2
?
B:
[45-269]
------------------------------
G
A
K
V
A
L
I
D
L
D
Q
G
L
A
E
R
S
A
A
M
L
S
-
T
G
-
G
--
A
V
A
K
G
--
F
G
A
D
V
T
K
A
A
D
I
T
A
A
I
T
S
A
E
Q
T
I
G
S
L
T
G
L
V
N
N
A
G
I
--
A
-
G
F
--
G
S
V
H
D
A
D
---------
A
A
A
-
W
D
R
I
M
A
V
N
V
T
G
T
F
L
A
S
K
A
A
L
A
G
M
L
E
R
-
H
K
G
T
I
V
N
F
G
S
-
V
A
G
-----
L
V
G
I
P
T
M
A
A
Y
C
A
A
K
G
A
I
V
N
L
T
R
Q
M
A
A
D
Y
S
G
R
G
V
R
V
N
A
V
C
P
G
T
V
T
S
T
G
M
-
G
Q
Q
L
L
----------------------
Q
--
A
R
R
L
A
----
K
Y
P
I
G
R
F
G
T
P
E
D
I
A
E
A
V
I
F
L
L
S
D
Q
A
A
F
V
T
G
A
A
F
A
V
D
G
G
M
T
A
I
89
PsiBlast_CBE
67.96
40%
-94
- C1 -
4GH5
2
?
D:
[45-269]
------------------------------
G
A
K
V
A
L
I
D
L
D
Q
G
L
A
E
R
S
A
A
M
L
S
-
T
G
-
G
--
A
V
A
K
G
--
F
G
A
D
V
T
K
A
A
D
I
T
A
A
I
T
S
A
E
Q
T
I
G
S
L
T
G
L
V
N
N
A
G
I
--
A
-
G
F
--
G
S
V
H
D
A
D
---------
A
A
A
-
W
D
R
I
M
A
V
N
V
T
G
T
F
L
A
S
K
A
A
L
A
G
M
L
E
R
-
H
K
G
T
I
V
N
F
G
S
-
V
A
G
-----
L
V
G
I
P
T
M
A
A
Y
C
A
A
K
G
A
I
V
N
L
T
R
Q
M
A
A
D
Y
S
G
R
G
V
R
V
N
A
V
C
P
G
T
V
T
S
T
G
M
-
G
Q
Q
L
L
----------------------
Q
--
A
R
R
L
A
----
K
Y
P
I
G
R
F
G
T
P
E
D
I
A
E
A
V
I
F
L
L
S
D
Q
A
A
F
V
T
G
A
A
F
A
V
D
G
G
M
T
A
I