@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA1737: (2016-02-01 )
MTDAIRYEKGQDNVVVLTMDMPGQSANTMNGVYREAMAKTIARLEAEKEGIAGVVLTSAKKTFFAGGDLNELIKVTKADAPAFYQGILELKGQLRRLETLGKPVVAAINGAALGGGWEICLACHHRIALDNPGVQLGLPEVTLGLLPGGGGIVRMVRLLGLEKALPYLAEGKKVRPAEALKAGLIHELADSPEEMLEKARAWILANPAAKQPWDSAGYKIPGGTPASPNVAQMLAIAPSVLRDKTKGCFPAPEKIMCAAVEGAQVDFDTAQLIEARYFTELTTGQVAKNMIGTFWFQLNEINAGKSRPQGYPVRATKKVGVLGAGMMGAGIAYVSAAAGIEVVLKDVSLEAAEKGKAYSARLLDKKVARGHLSAEKRDAFLARIVPSVSEADFEGCDLIIEAVFEDRALKGKVTAEAEKHALADAVVASNTSTLPITGLAQAVARPEKFIGLHFFSPVDKMPLVEIIRGEKTSDETLARGFDYVLQIKKTPIVVNDSRGFFTSRVFGTFTNEGIAMLGEGVSAAMIDNQARQAGMPVGPLAISDEVSLSLMTHIRNQTARDLEAEGKALPTHPAFAVIDLMVNEYKRPGKAAGAGFYDYPANGRKHLWAELKSRFEKPDAQISAEDVRDRLLFIQAIETVRCVEEGVLHSTADANIGSIFGIGFAAWSGGALQFINQYGLKDFIARAQYLVEQYGERFEPPALLLEKAAKGELF
Atome Classification :
(32 SA)
---.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160..-.....170.......180....------..--.190.......200..----...--..210.......220........230....--...240......-.250......-.260.......270-.......280.......290.......300-...-....310...-----....320.......330.......340......---.350.......360.......370..--...--..380.......390-----.-......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520........530-..--.....540..----.....550.......560.......570-------.---.......580......---.590.......600-..---..--------...610...-----------...----.-----------620.......630.......640.......650.......660.......670......------.680.......690....--...700.......710..--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MTD
A
I
R
YEKGQD
N
V
V
V
L
T
MDMPGQSAN
T
M
N
G
V
Y
R
E
A
M
A
K
T
I
A
R
L
E
A
EKEGI
A
G
V
V
L
TSAK
K
T
F
FAGG
D
L
N
E
L
I
K
V
TKAD
A
P
A
F
Y
Q
G
I
L
E
L
K
G
Q
L
R
R
L
E
T
LG
K
P
V
V
A
AINGAALGG
G
W
E
I
C
L
A
CH
H
R
I
ALDNPG
V
Q
LGLP
E
V
T
L
G
L
LPG
G
G
G
I
V
R
M
V
R
L
L
G
L
E
K
A
-
L
P
Y
L
AEGKKVR
P
A
E
A
L
K
A
G
L
I
H
------
E
L--AD
S
P
E
E
M
L
E
K
A
R
A
W
I
L
----ANP--AAKQPWDSAGYKI-PGGTPAS
P
N
V
A
Q
M
L
A
I--
A
P
S
V
L
R
DKTKGC-FPA
P
E
K
I
M
C
A
-AVEGAQVD
F
D
T
A
Q
L
-
I
E
A
R
Y
F
T
EL
T
T
G
Q
V
A
K
N
M
I
G
T
F
W
F
Q
L
NEIN-AGK-SRPQGYPVR
A
-----
T
K
K
VGVLGA
G
M
M
G
A
G
I
A
Y
V
S
AAAG
I
E
V
V
L
KDVS---
L
E
A
AEKGK
A
Y
S
A
R
L
L
D
K
K
V
ARGHL
S
A
--
E
K
R
--
D
A
F
L
A
R
IVPSVSEAD-----F-E
G
C
D
L
I
I
E
A
V
F
EDRALKGKV
T
A
E
A
E
K
H
A
L
A
D
A
V
VASNTSTL
P
I
T
G
L
A
Q
A
VARPE
K
F
I
G
L
H
FFSPVDK
M
P
L
V
E
I
IRGEKTS
D
E
T
L
A
R
G
F
D
Y
V
L
Q
I
KKT
P
I
V
V
NDSRG
F
F
TS
R
V
F
GTFTN
E
G
I
A
M
L
GEG-
V
S
A
A
M
I
D
N
Q
A
R
Q-AG--MPVG
P
L
AIS
D
----
E
V
S
L
S
L
M
T
H
I
R
NQTARDLEAEGKALPT--------H---
P
A
F
A
V
I
D
L
M
V
N
E
YKRP---GKAAGAGFYDYPAN-G
R
---
K
H
--------
L
W
A
E
L
K
S
R
F-----------EKP----D-----------AQI
S
A
E
D
V
R
D
R
L
L
F
I
Q
A
I
E
T
V
R
C
V
E
EGVLHSTADANI
G
S
I
F
G
I
G
FAAWSG
G
A
L
Q
F
I
N
Q
Y------G
L
K
D
F
I
A
R
A
Q
Y
L
V
E
Q
Y
GE--RFE
P
P
A
L
L
L
E
K
AAKGELF--
3
PsiBlast_PDB
99.16
57%
-91
- C1 -
4B3J
10
?
A:
[20-735]
-----
N
T
I
Q
W
D
K
D
A
D
G
I
V
T
L
T
M
D
D
P
S
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
R
P
E
D
A
G
D
V
F
N
T
V
E
T
I
K
R
Q
L
R
T
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
V
K
G
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
I
G
L
V
D
------
E
L
--
V
A
T
V
E
E
L
V
P
A
A
K
A
W
I
K
E
E
L
K
A
N
P
DG
A
G
V
Q
P
W
D
K
K
G
Y
K
M
-
P
G
G
T
P
S
S
P
G
L
A
A
I
L
P
S
--
F
P
S
N
L
R
K
Q
L
K
G
A
P
M
P
A
P
R
A
I
L
A
A
-
A
V
E
G
A
Q
V
D
F
D
T
A
S
R
-
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
I
N
-
A
G
G
-
S
R
P
E
G
I
G
K
T
P
-----
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
---
L
E
A
A
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
L
E
R
G
R
T
T
Q
--
E
R
S
--
D
A
L
L
A
R
I
T
P
T
A
D
A
A
D
-----
F
-
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
G
E
G
-
V
E
P
A
S
I
E
Q
A
G
S
Q
-
A
G
--
Y
P
A
P
P
L
Q
L
S
D
----
E
L
N
L
E
L
M
H
K
I
A
V
A
T
R
K
G
V
E
D
A
G
G
T
Y
Q
P
--------
H
---
P
A
E
A
V
V
E
K
M
I
-
E
L
G
R
S
---
G
R
L
K
G
A
G
F
Y
E
Y
A
D
G
-
K
R
---
S
G
--------
L
W
P
G
L
R
E
T
F
-----------
K
S
G
----
S
-----------
S
Q
P
P
L
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
Y
SGPAGT
G
K
A
A
F
V
A
R
A
R
E
L
A
A
A
Y
G
D
--
R
F
L
P
P
E
S
L
L
S
----------
1
PsiBlast_PDB
99.04
57%
-92
- C1 -
4B3H
10
?
A:
[20-735]
-----
N
T
I
Q
W
D
K
D
A
D
G
I
V
T
L
T
M
D
D
P
S
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
R
P
E
D
A
G
D
V
F
N
T
V
E
T
I
K
R
Q
L
R
T
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
V
K
G
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
I
G
L
V
D
------
E
L
--
V
A
T
V
E
E
L
V
P
A
A
K
A
W
I
K
E
E
L
K
A
N
P
DG
A
G
V
Q
P
W
D
K
K
G
Y
K
M
-
P
G
G
T
P
S
S
P
G
L
A
A
I
L
P
S
--
F
P
S
N
L
R
K
Q
L
K
G
A
P
M
P
A
P
R
A
I
L
A
A
-
A
V
E
G
A
Q
V
D
F
D
T
A
S
R
-
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
I
N
-
A
G
G
-
S
R
P
E
G
I
G
K
T
P
-----
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
---
L
E
A
A
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
L
E
R
G
R
T
T
Q
--
E
R
S
--
D
A
L
L
A
R
I
T
P
T
A
D
A
A
D
-----
F
-
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
G
E
G
-
V
E
P
A
S
I
E
Q
A
G
S
Q
-
A
G
--
Y
P
A
P
P
L
Q
L
S
D
----
E
L
N
L
E
L
M
H
K
I
A
V
A
T
R
K
G
V
E
D
A
G
G
T
Y
Q
P
--------
H
---
P
A
E
A
V
V
E
K
M
I
-
E
L
G
R
S
---
G
R
L
K
G
A
G
F
Y
E
Y
A
D
G
-
K
R
---
S
G
--------
L
W
P
G
L
R
E
T
F
-----------
K
S
G
----
S
-----------
S
Q
P
P
L
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
Y
SGPAGT
G
K
A
A
F
V
A
R
A
R
E
L
A
A
A
Y
G
D
--
R
F
L
P
P
E
S
L
L
S
----------
2
PsiBlast_PDB
98.99
57%
-92
- C1 -
4B3I
10
?
A:
[20-735]
-----
N
T
I
Q
W
D
K
D
A
D
G
I
V
T
L
T
M
D
D
P
S
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
R
P
E
D
A
G
D
V
F
N
T
V
E
T
I
K
R
Q
L
R
T
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
V
K
G
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
I
G
L
V
D
------
E
L
--
V
A
T
V
E
E
L
V
P
A
A
K
A
W
I
K
E
E
L
K
A
N
P
DG
A
G
V
Q
P
W
D
K
K
G
Y
K
M
-
P
G
G
T
P
S
S
P
G
L
A
A
I
L
P
S
--
F
P
S
N
L
R
K
Q
L
K
G
A
P
M
P
A
P
R
A
I
L
A
A
-
A
V
E
G
A
Q
V
D
F
D
T
A
S
R
-
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
I
N
-
A
G
G
-
S
R
P
E
G
I
G
K
T
P
-----
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
---
L
E
A
A
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
L
E
R
G
R
T
T
Q
--
E
R
S
--
D
A
L
L
A
R
I
T
P
T
A
D
A
A
D
-----
F
-
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
G
E
G
-
V
E
P
A
S
I
E
Q
A
G
S
Q
-
A
G
--
Y
P
A
P
P
L
Q
L
S
D
----
E
L
N
L
E
L
M
H
K
I
A
V
A
T
R
K
G
V
E
D
A
G
G
T
Y
Q
P
--------
H
---
P
A
E
A
V
V
E
K
M
I
-
E
L
G
R
S
---
G
R
L
K
G
A
G
F
Y
E
Y
A
D
G
-
K
R
---
S
G
--------
L
W
P
G
L
R
E
T
F
-----------
K
S
G
----
S
-----------
S
Q
P
P
L
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
Y
SGPAGT
G
K
A
A
F
V
A
R
A
R
E
L
A
A
A
Y
G
D
--
R
F
L
P
P
E
S
L
L
S
----------
21
PsiBlast_CBE
98.71
57%
-91
- C1 -
4B3J
10
?
B:
[20-735]
-----
N
T
I
Q
W
D
K
D
A
D
G
I
V
T
L
T
M
D
D
P
S
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
R
P
E
D
A
G
D
V
F
N
T
V
E
T
I
K
R
Q
L
R
T
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
V
K
G
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
I
G
L
V
D
------
E
L
--
V
A
T
V
E
E
L
V
P
A
A
K
A
W
I
K
E
E
L
K
A
N
P
DG
A
G
V
Q
P
W
D
K
K
G
Y
K
M
-
P
G
G
T
P
S
S
P
G
L
A
A
I
L
P
S
--
F
P
S
N
L
R
K
Q
L
K
G
A
P
M
P
A
P
R
A
I
L
A
A
-
A
V
E
G
A
Q
V
D
F
D
T
A
S
R
-
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
I
N
-
A
G
G
-
S
R
P
E
G
I
G
K
T
P
-----
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
---
L
E
A
A
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
L
E
R
G
R
T
T
Q
--
E
R
S
--
D
A
L
L
A
R
I
T
P
T
A
D
A
A
D
-----
F
-
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
G
E
G
-
V
E
P
A
S
I
E
Q
A
G
S
Q
-
A
G
--
Y
P
A
P
P
L
Q
L
S
D
----
E
L
N
L
E
L
M
H
K
I
A
V
A
T
R
K
G
V
E
D
A
G
G
T
Y
Q
P
--------
H
---
P
A
E
A
V
V
E
K
M
I
-
E
L
G
R
S
---
G
R
L
K
G
A
G
F
Y
E
Y
A
D
G
-
K
R
---
S
G
--------
L
W
P
G
L
R
E
T
F
-----------
K
S
G
----
S
-----------
S
Q
P
P
L
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
Y
SGPAGT
G
K
A
A
F
V
A
R
A
R
E
L
A
A
A
Y
G
D
--
R
F
L
P
P
E
S
L
L
S
----------
23
PsiBlast_CBE
98.53
57%
-90
- C1 -
4B3H
11
?
B:
[20-735]
-----
N
T
I
Q
W
D
K
D
A
D
G
I
V
T
L
T
M
D
D
P
S
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
R
P
E
D
A
G
D
V
F
N
T
V
E
T
I
K
R
Q
L
R
T
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
V
K
G
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
I
G
L
V
D
------
E
L
--
V
A
T
V
E
E
L
V
P
A
A
K
A
W
I
K
E
E
L
K
A
N
P
DG
A
G
V
Q
P
W
D
K
K
G
Y
K
M
-
P
G
G
T
P
S
S
P
G
L
A
A
I
L
P
S
--
F
P
S
N
L
R
K
Q
L
K
G
A
P
M
P
A
P
R
A
I
L
A
A
-
A
V
E
G
A
Q
V
D
F
D
T
A
S
R
-
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
I
N
-
A
G
G
-
S
R
P
E
G
I
G
K
T
P
-----
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
---
L
E
A
A
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
L
E
R
G
R
T
T
Q
--
E
R
S
--
D
A
L
L
A
R
I
T
P
T
A
D
A
A
D
-----
F
-
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
G
E
G
-
V
E
P
A
S
I
E
Q
A
G
S
Q
-
A
G
--
Y
P
A
P
P
L
Q
L
S
D
----
E
L
N
L
E
L
M
H
K
I
A
V
A
T
R
K
G
V
E
D
A
G
G
T
Y
Q
P
--------
H
---
P
A
E
A
V
V
E
K
M
I
-
E
L
G
R
S
---
G
R
L
K
G
A
G
F
Y
E
Y
A
D
G
-
K
R
---
S
G
--------
L
W
P
G
L
R
E
T
F
-----------
K
S
G
----
S
-----------
S
Q
P
P
L
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
Y
SGPAGT
G
K
A
A
F
V
A
R
A
R
E
L
A
A
A
Y
G
D
--
R
F
L
P
P
E
S
L
L
S
----------
22
PsiBlast_CBE
97.77
57%
-90
- C1 -
4B3I
10
?
B:
[20-735]
-----
N
T
I
Q
W
D
K
D
A
D
G
I
V
T
L
T
M
D
D
P
S
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
R
P
E
D
A
G
D
V
F
N
T
V
E
T
I
K
R
Q
L
R
T
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
V
K
G
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
I
G
L
V
D
------
E
L
--
V
A
T
V
E
E
L
V
P
A
A
K
A
W
I
K
E
E
L
K
A
N
P
DG
A
G
V
Q
P
W
D
K
K
G
Y
K
M
-
P
G
G
T
P
S
S
P
G
L
A
A
I
L
P
S
--
F
P
S
N
L
R
K
Q
L
K
G
A
P
M
P
A
P
R
A
I
L
A
A
-
A
V
E
G
A
Q
V
D
F
D
T
A
S
R
-
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
I
N
-
A
G
G
-
S
R
P
E
G
I
G
K
T
P
-----
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
---
L
E
A
A
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
L
E
R
G
R
T
T
Q
--
E
R
S
--
D
A
L
L
A
R
I
T
P
T
A
D
A
A
D
-----
F
-
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
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P
V
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M
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L
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I
K
G
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K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
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G
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T
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I
V
V
N
D
S
R
G
F
F
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S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
G
E
G
-
V
E
P
A
S
I
E
Q
A
G
S
Q
-
A
G
--
Y
P
A
P
P
L
Q
L
S
D
----
E
L
N
L
E
L
M
H
K
I
A
V
A
T
R
K
G
V
E
D
A
G
G
T
Y
Q
P
--------
H
---
P
A
E
A
V
V
E
K
M
I
-
E
L
G
R
S
---
G
R
L
K
G
A
G
F
Y
E
Y
A
D
G
-
K
R
---
S
G
--------
L
W
P
G
L
R
E
T
F
-----------
K
S
G
----
S
-----------
S
Q
P
P
L
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
Y
SGPAGT
G
K
A
A
F
V
A
R
A
R
E
L
A
A
A
Y
G
D
--
R
F
L
P
P
E
S
L
L
S
----------
27
PsiBlast_CBE
82.27
34%
-86
- C1 -
1WDK
3
FADB_PSEFR
B:
[14-713]
-------------
E
S
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
D
A
S
-
V
K
G
V
I
V
S
S
G
K
D
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
D
A
E
L
I
A
G
N
L
E
A
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
S
--
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
D
AVVTAD
K
L
--
G
A
A
A
L
D
L
I
K
R
A
I
S
G
E
L
----
D
Y
K
--
A
K
R
Q
P
-
K
L
E
K
L
K
L
-
N
A
-------
I
E
Q
M
M
A
F
ET
A
K
G
F
V
A
G
Q
A
G
P
N
-
Y
P
A
P
V
E
A
I
K
T
-
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
-
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
---
L
N
D
Q
E
L
K
K
K
-
A
K
V
Y
D
K
I
A
K
D
-----
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
---
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
V
D
K
G
R
M
T
P
--
A
K
M
--
A
E
V
L
N
G
I
R
P
T
L
S
Y
G
D
-----
F
-
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
S
A
G
-
V
D
F
V
R
I
D
K
V
M
E
K
-
F
G
--
W
P
M
G
P
A
Y
L
M
D
----
V
V
G
I
D
T
G
H
H
-----
G
R
D
V
M
A
E
G
--
F
P
D
--------
R
MKD
D
R
R
S
A
I
D
A
L
Y
-
E
A
K
R
L
---
G
Q
K
N
G
K
G
F
Y
A
Y
E
A
D
---Q--
K
K
--------
L
V
D
S
S
V
L
E
V
-----------
L
K
P
IVYE
Q
-----------
R
D
V
T
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
D
S
I
------
G
V
A
E
F
V
A
L
A
D
Q
Y
A
E
-
L
G
A
--
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
--
106
Fugue
81.56
33%
-82
- C1 -
1WDK
4
FADB_PSEFR
A:
[1-715]
MIY
E
G
K
A
I
T
V
T
A
L
E
S
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
D
A
S
-
V
K
G
V
I
V
S
S
G
K
D
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
D
A
E
L
I
A
G
N
L
E
A
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
S
--
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
D
------
A
V
--
V
T
-
A
D
K
L
G
A
A
A
L
D
L
I
K
----
R
A
I
--
S
G
E
L
D
Y
K
A
K
R
Q
P
K
L
E
K
L
K
L
N
A
I
E
Q
M
M
A
F
E
T
--
A
K
G
F
V
A
G
Q
A
G
P
N
-
Y
P
A
P
V
E
A
I
K
T
-
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
-
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
L
N
D
Q
E
L
K
K
-
K
A
K
-
V
Y
D
K
--
I
A
K
D
-----
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
---
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
V
D
K
G
R
M
T
P
--
A
K
M
--
A
E
V
L
N
G
I
R
P
T
L
S
Y
G
D
-----
F
-
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
S
A
G
-
V
D
F
V
R
I
D
K
V
M
E
K
-
F
G
--
W
P
M
G
P
A
Y
L
M
D
----
V
V
G
I
D
T
G
H
H
G
R
D
V
M
A
E
G
F
P
D
R
M
K
D
D
R
R
--------
S
--------
A
I
D
A
L
Y
E
A
K
R
L
---
G
Q
K
N
G
K
G
F
Y
A
Y
E
K
K
-
L
V
---
D
S
--------
S
V
L
E
V
L
K
P
I
-----------
V
Y
E
----
Q
-----------
R
D
V
T
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
D
S
I
------
G
V
A
E
F
V
A
L
A
D
Q
Y
A
E
L
-
G
A
--
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
FG
5
PsiBlast_PDB
80.74
34%
-84
- C1 -
1WDM
3
FADB_PSEFR
A:
[14-713]
-------------
E
S
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
D
A
S
-
V
K
G
V
I
V
S
S
G
K
D
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
D
A
E
L
I
A
G
N
L
E
A
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
S
--
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
D
A
V
V
T
AD
K
L
--
G
A
A
A
L
D
L
I
K
R
A
I
S
G
E
L
----
D
Y
K
--
A
K
R
Q
P
-
K
L
E
K
L
K
L
-
N
A
-------
I
E
Q
M
M
A
F
E
T
A
K
G
F
V
A
G
Q
A
G
P
N
-
Y
P
A
P
V
E
A
I
K
T
-
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
-
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
---
L
N
D
Q
E
L
K
K
K
-
A
K
V
Y
D
K
I
A
K
D
-----
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
---
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
V
D
K
G
R
M
T
P
--
A
K
M
--
A
E
V
L
N
G
I
R
P
T
L
S
Y
G
D
-----
F
-
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
S
A
G
-
V
D
F
V
R
I
D
K
V
M
E
K
-
F
G
--
W
P
M
G
P
A
Y
L
M
D
----
V
V
G
I
D
T
G
H
H
-----
G
R
D
V
M
A
E
G
--
F
P
D
--------
R
MKD
D
R
R
S
A
I
D
A
L
Y
-
E
A
K
R
L
---
G
Q
K
N
G
K
G
F
Y
A
Y
---------
K
K
--------
L
V
D
S
S
V
L
E
V
-----------
L
K
P
IVYE
Q
-----------
R
D
V
T
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
D
S
I
------
G
V
A
E
F
V
A
L
A
D
Q
Y
A
E
-
L
G
A
--
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
--
25
PsiBlast_CBE
80.70
34%
-85
- C1 -
1WDM
1
FADB_PSEFR
B:
[14-713]
-------------
E
S
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
D
A
S
-
V
K
G
V
I
V
S
S
G
K
D
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
D
A
E
L
I
A
G
N
L
E
A
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
S
--
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
D
AVVTAD
K
L
--
G
A
A
A
L
D
L
I
K
R
A
I
S
G
E
L
----
D
Y
K
--
A
K
R
Q
P
-
K
L
E
K
L
K
L
-
N
A
-------
I
E
Q
M
M
A
F
ET
A
K
G
F
V
A
G
Q
A
G
P
N
-
Y
P
A
P
V
E
A
I
K
T
-
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
-
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
---
L
N
D
Q
E
L
K
K
K
-
A
K
V
Y
D
K
I
A
K
D
-----
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
---
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
V
D
K
G
R
M
T
P
--
A
K
M
--
A
E
V
L
N
G
I
R
P
T
L
S
Y
G
D
-----
F
-
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
S
A
G
-
V
D
F
V
R
I
D
K
V
M
E
K
-
F
G
--
W
P
M
G
P
A
Y
L
M
D
----
V
V
G
I
D
T
G
H
H
-----
G
R
D
V
M
A
E
G
--
F
P
D
--------
R
MKD
D
R
R
S
A
I
D
A
L
Y
-
E
A
K
R
L
---
G
Q
K
N
G
K
G
F
Y
A
Y
E
-----KQ-
K
K
--------
L
V
D
S
S
V
L
E
V
-----------
L
K
P
IVYE
Q
-----------
R
D
V
T
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
D
S
I
------
G
V
A
E
F
V
A
L
A
D
Q
Y
A
E
-
L
G
A
--
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
--
24
PsiBlast_CBE
80.69
34%
-87
- C1 -
2D3T
1
FADB_PSEFR
B:
[14-713]
-------------
E
S
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
D
A
S
-
V
K
G
V
I
V
S
S
G
K
D
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
D
A
E
L
I
A
G
N
L
E
A
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
S
--
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
D
AVVTAD
K
L
--
G
A
A
A
L
D
L
I
K
R
A
I
S
G
E
L
----
D
Y
K
--
A
K
R
Q
P
-
K
L
E
K
L
K
L
-
N
A
-------
I
E
Q
M
M
A
F
ET
A
K
G
F
V
A
G
Q
A
G
P
N
-
Y
P
A
P
V
E
A
I
K
T
-
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
-
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
---
L
N
D
Q
E
L
K
K
K
-
A
K
V
Y
D
K
I
A
K
D
-----
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
---
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
V
D
K
G
R
M
T
P
--
A
K
M
--
A
E
V
L
N
G
I
R
P
T
L
S
Y
G
D
-----
F
-
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
S
A
G
-
V
D
F
V
R
I
D
K
V
M
E
K
-
F
G
--
W
P
M
G
P
A
Y
L
M
D
----
V
V
G
I
D
T
G
H
H
-----
G
R
D
V
M
A
E
G
--
F
P
D
--------
R
MKD
D
R
R
S
A
I
D
A
L
Y
-
E
A
K
R
L
---
G
Q
K
N
G
K
G
F
Y
A
Y
E
A
D
---Q--
K
K
--------
L
V
D
S
S
V
L
E
V
-----------
L
K
P
IVYE
Q
-----------
R
D
V
T
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
D
S
I
------
G
V
A
E
F
V
A
L
A
D
Q
Y
A
E
-
L
G
A
--
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
--
26
PsiBlast_CBE
79.32
34%
-83
* C1 *
1WDL
2
FADB_PSEFR
B:
[14-713]
-------------
E
S
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
D
A
S
-
V
K
G
V
I
V
S
S
G
K
D
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
D
A
E
L
I
A
G
N
L
E
A
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
S
--
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
D
AVVTAD
K
L
--
G
A
A
A
L
D
L
I
K
R
A
I
S
G
E
L
----
D
Y
K
--
A
K
R
Q
P
-
K
L
E
K
L
K
L
-
N
A
-------
I
E
Q
M
M
A
F
ET
A
K
G
F
V
A
G
Q
A
G
P
N
-
Y
P
A
P
V
E
A
I
K
T
-
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
-
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
---
L
N
D
Q
E
L
K
K
K
-
A
K
V
Y
D
K
I
A
K
D
-----
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
---
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
V
D
K
G
R
M
T
P
--
A
K
M
--
A
E
V
L
N
G
I
R
P
T
L
S
Y
G
D
-----
F
-
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
S
A
G
-
V
D
F
V
R
I
D
K
V
M
E
K
-
F
G
--
W
P
M
G
P
A
Y
L
M
D
----
V
V
G
I
D
T
G
H
H
-----
G
R
D
V
M
A
E
G
--
F
P
D
--------
R
MKD
D
R
R
S
A
I
D
A
L
Y
-
E
A
K
R
L
---
G
Q
K
N
G
K
G
F
Y
A
Y
----------
K
--------
L
V
D
S
S
V
L
E
V
-----------
L
K
P
IVYE
Q
-----------
R
D
V
T
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
D
S
I
------
G
V
A
E
F
V
A
L
A
D
Q
Y
A
E
-
L
G
A
--
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
--
4
PsiBlast_PDB
78.28
34%
-81
- C1 -
1WDL
4
FADB_PSEFR
A:
[14-713]
-------------
E
S
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
D
A
S
-
V
K
G
V
I
V
S
S
G
K
D
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
D
A
E
L
I
A
G
N
L
E
A
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
S
--
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
D
A
V
V
T
AD
K
L
--
G
A
A
A
L
D
L
I
K
R
A
I
S
G
E
L
----
D
Y
K
--
A
K
R
Q
P
-
K
L
E
K
L
K
L
-
N
A
-------
I
E
Q
M
M
A
F
E
T
A
K
G
F
V
A
G
Q
A
G
P
N
-
Y
P
A
P
V
E
A
I
K
T
-
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
-
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
---
L
N
D
Q
E
L
K
K
K
-
A
K
V
Y
D
K
I
A
K
D
-----
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
---
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
V
D
K
G
R
M
T
P
--
A
K
M
--
A
E
V
L
N
G
I
R
P
T
L
S
Y
G
D
-----
F
-
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
S
A
G
-
V
D
F
V
R
I
D
K
V
M
E
K
-
F
G
--
W
P
M
G
P
A
Y
L
M
D
----
V
V
G
I
D
T
G
H
H
-----
G
R
D
V
M
A
E
G
--
F
P
D
--------
R
MKD
D
R
R
S
A
I
D
A
L
Y
-
E
A
K
R
L
---
G
Q
K
N
G
K
G
F
Y
A
Y
E
A
D
-
K
K
G
K
Q
K
K
--------
L
V
D
S
S
V
L
E
V
-----------
L
K
P
IVYE
Q
-----------
R
D
V
T
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
D
S
I
------
G
V
A
E
F
V
A
L
A
D
Q
Y
A
E
-
L
G
A
--
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
--
115
HHSearch
74.52
30%
-83
- C1 -
2WTB
-
MFP2_ARATH
A:
[9-714]
-------
T
V
M
E
V
G
G
D
G
V
A
V
I
T
L
I
N
P
--
P
V
N
S
L
S
F
D
V
L
Y
N
L
K
S
N
Y
E
E
A
-
L
S
R
N
D
V
K
A
I
V
I
T
G
A
K
G
R
F
S
G
G
F
D
I
------------
E
P
K
A
G
Y
I
S
I
D
I
I
T
D
L
L
E
A
A
R
K
P
S
V
A
A
I
D
G
L
A
L
G
G
G
L
E
L
A
M
A
C
H
A
R
I
S
A
P
--
A
A
Q
L
G
L
P
E
L
Q
L
G
V
I
P
G
F
G
G
T
Q
R
L
P
R
L
V
G
L
T
K
A
-
L
E
M
I
L
T
S
K
P
V
K
A
E
E
G
H
S
L
G
L
I
D
------
A
V
--
V
P
P
-
A
E
L
V
T
T
A
R
R
W
A
L
----
D
I
V
--
G
R
R
K
P
W
V
S
S
V
S
K
T
-
D
K
L
P
P
L
G
E
A
R
-
E
I
L
T
F
--
A
K
A
Q
T
L
K
R
-
A
P
N
-
M
K
H
P
L
M
C
L
D
A
-
I
E
V
G
I
V
S
G
P
R
A
G
L
E
-
K
E
A
E
V
A
S
Q
V
V
K
L
D
T
T
K
G
L
I
H
V
F
F
S
Q
R
G
T
A
K
-
V
P
G
-
V
T
D
R
G
L
V
P
R
K
-----
I
K
K
V
A
I
I
G
G
G
L
M
G
S
G
I
A
T
A
L
I
L
S
N
Y
P
V
I
L
K
E
V
N
---
E
K
F
L
E
A
G
I
G
R
V
K
A
N
L
Q
S
R
V
R
----
S
Q
--
E
K
F
--
E
K
T
M
S
L
L
K
G
S
L
D
Y
E
S
-----
F
-
R
D
V
D
M
V
I
E
A
V
I
E
N
I
S
L
K
Q
Q
I
F
A
D
L
E
K
Y
C
P
Q
H
C
I
L
A
S
N
T
S
T
I
D
L
N
K
I
G
E
R
T
K
S
Q
D
R
I
V
G
A
H
F
F
S
P
A
H
I
M
P
L
L
E
I
V
R
T
N
H
T
S
A
Q
V
I
V
D
L
L
D
V
G
K
K
I
K
K
T
P
V
V
V
G
N
C
T
G
F
A
V
N
R
M
F
F
P
Y
T
Q
A
A
M
F
L
V
E
C
G
-
A
D
P
Y
L
I
D
R
A
I
S
K
-
F
G
--
M
P
M
G
P
F
R
L
C
D
----
L
V
G
F
G
V
A
I
A
T
A
T
Q
F
I
E
N
F
S
E
R
T
-----------------
Y
K
S
M
I
I
P
L
M
Q
-
E
D
K
------------------------------------
D
P
E
L
K
K
Y
I
E
K
A
R
S
I
S
GV
K
L
D
P
K
----
L
-----------
A
N
L
S
E
K
D
I
I
E
M
T
F
F
P
V
V
N
E
A
C
R
V
F
A
E
G
I
A
V
K
A
A
D
L
D
I
A
G
I
M
G
M
G
F
P
P
Y
R
G
G
I
M
F
W
A
D
S
I
------
G
S
K
Y
I
Y
S
R
L
D
E
W
S
K
A
Y
G
E
--
F
F
K
P
C
A
F
L
A
E
R
G
S
K
G
V
L
L
--
6
PsiBlast_PDB
72.57
30%
-77
- C1 -
2WTB
-
MFP2_ARATH
A:
[12-714]
----------
E
V
G
G
D
G
V
A
V
I
T
L
I
N
P
P
V
N
S
L
S
F
D
V
L
Y
N
---
L
K
S
N
Y
E
E
A
L
S
R
N
D
V
K
A
I
V
I
T
G
A
K
G
R
F
S
G
G
F
D
I
------------
E
P
K
A
G
Y
I
S
I
D
I
I
T
D
L
L
E
A
A
R
K
P
S
V
A
A
I
D
G
L
A
L
G
G
G
L
E
L
A
M
A
C
H
A
R
I
S
--
A
P
A
A
Q
L
G
L
P
E
L
Q
L
G
V
I
P
G
F
G
G
T
Q
R
L
P
R
L
V
G
L
T
K
A
-
L
E
M
I
L
T
S
K
P
V
K
A
E
E
G
H
S
L
G
L
I
D
------
A
V
--
V
-
P
P
A
E
L
V
T
T
A
R
R
W
A
L
----
D
I
V
--
G
R
R
K
P
W
V
S
S
V
S
K
-----
T
D
K
L
P
P
L
G
E
A
R
E
I
--
L
T
F
A
K
A
Q
T
L
K
R
A
-
P
N
M
K
H
P
L
M
C
L
D
A
I
E
V
G
I
V
S
G
P
R
A
G
L
E
K
E
A
E
V
A
S
Q
V
V
K
L
D
T
T
K
G
L
I
H
V
F
F
S
Q
R
G
T
A
K
-
V
P
G
-
V
T
D
R
G
L
V
P
R
K
-----
I
K
K
V
A
I
I
G
G
G
L
M
G
S
G
I
A
T
A
L
I
L
S
N
Y
P
V
I
L
K
E
V
N
---
E
K
F
L
E
A
G
I
G
R
V
K
A
N
L
Q
S
R
V
R
----
S
Q
--
E
K
F
--
E
K
T
M
S
L
L
K
G
S
L
D
Y
E
S
-----
F
-
R
D
V
D
M
V
I
E
A
V
I
E
N
I
S
L
K
Q
Q
I
F
A
D
L
E
K
Y
C
P
Q
H
C
I
L
A
S
N
T
S
T
I
D
L
N
K
I
G
E
R
T
K
S
Q
D
R
I
V
G
A
H
F
F
S
P
A
H
I
M
P
L
L
E
I
V
R
T
N
H
T
S
A
Q
V
I
V
D
L
L
D
V
G
K
K
I
K
K
T
P
V
V
V
G
N
C
T
G
F
A
V
N
R
M
F
F
P
Y
T
Q
A
A
M
F
L
V
E
C
G
-
A
D
P
Y
L
I
D
R
A
I
S
K
-
F
G
--
M
P
M
G
P
F
R
L
C
D
----
L
V
G
F
G
V
A
I
A
T
A
T
Q
F
I
E
N
F
S
E
R
-----
T
--------
Y
---
K
S
M
-
I
I
P
L
M
-
Q
E
D
K
------------------------------------
D
P
E
L
K
K
Y
I
-----------
E
K
A
----
R
S
I
S
GV
K
L
D
P
KL
A
N
L
S
E
K
D
I
I
E
M
T
F
F
P
V
V
N
E
A
C
R
V
F
A
E
G
I
A
V
K
A
A
D
L
D
I
A
G
I
M
G
M
G
F
P
P
Y
R
G
G
I
M
F
W
A
D
S
I
------
G
S
K
Y
I
Y
S
R
L
D
E
W
S
K
A
Y
G
E
--
F
F
K
P
C
A
F
L
A
E
R
G
S
K
G
V
L
L
--
11
PsiBlast_PDB
69.84
28%
-81
- C1 -
2X58
6
ECHP_RAT
A:
[50-709]
-----------------------------------------------------
V
K
A
I
V
I
C
G
A
N
G
N
F
C
A
G
A
D
I
H
G
F
--------
S
A
F
T
P
G
-
L
A
L
G
S
L
V
D
E
I
Q
R
Y
Q
K
P
V
L
A
A
I
Q
G
V
A
L
G
G
G
L
E
L
A
L
G
C
H
Y
R
I
A
--
N
A
K
A
R
V
G
L
P
E
V
T
L
G
I
L
P
G
A
R
G
T
Q
L
L
P
R
V
V
G
V
P
V
A
-
L
D
L
I
T
S
G
K
Y
L
S
A
D
E
A
L
R
L
G
I
L
D
------
A
V
VK
S
D
P
V
E
E
A
I
K
F
A
Q
K
I
I
D
----
K
P
I
--
E
P
R
R
I
F
N
K
P
--------
V
P
S
L
P
N
M
D
S
V
F
A
E
--
A
I
A
K
V
R
K
Q
Y
P
G
V
-
L
-
A
P
E
T
C
V
R
S
-
I
Q
A
S
V
K
H
P
Y
E
V
G
I
K
-
E
E
E
K
L
F
M
Y
L
R
A
S
G
Q
A
K
A
L
Q
Y
A
F
F
---
A
E
K
S
-
A
N
K
W
S
T
P
S
G
A
S
W
K
T
A
S
A
Q
P
V
S
S
V
G
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
---
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
L
E
K
E
A
S
R
A
H
Q
N
G
--
Q
A
S
--
A
K
P
K
L
R
F
--
S
S
S
T
K
E
-----
L
-
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
F
F
L
L
E
E
G
-
S
K
P
E
D
V
D
G
V
L
E
E
-
F
G
--
F
K
M
G
P
F
R
V
S
D
----
L
A
G
L
D
V
G
W
K
I
R
K
G
Q
G
----
L
T
G
P
S
L
P
P
GTPVRKRG
N
---
S
R
Y
S
P
L
G
D
M
L
C
E
A
G
R
F
---
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
L
G
R
---
I
H
K
P
D
P
W
L
S
T
F
L
S
Q
Y
R
E
V
H
-----------
H
I
E
----
Q
-----------
R
T
I
S
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
A
A
S
V
------
G
L
P
T
V
L
E
K
L
Q
K
Y
Y
R
Q
N
P
D
IP
Q
L
E
P
S
D
Y
L
R
R
L
V
A
Q
G
S
P
P
--
12
PsiBlast_PDB
69.72
28%
-81
- C1 -
3ZWB
3
ECHP_RAT
A:
[65-724]
-----------------------------------------------------
V
K
A
I
V
I
C
G
A
N
G
N
F
C
A
G
A
D
I
H
G
F
--------
S
A
F
T
P
G
-
L
A
L
G
S
L
V
D
E
I
Q
R
Y
Q
K
P
V
L
A
A
I
Q
G
V
A
L
G
G
G
L
E
L
A
L
G
C
H
Y
R
I
A
--
N
A
K
A
R
V
G
L
P
A
V
T
L
G
I
L
P
G
A
R
G
T
Q
L
L
P
R
V
V
G
V
P
V
A
-
L
D
L
I
T
S
G
K
Y
L
S
A
D
E
A
L
R
L
G
I
L
D
------
A
V
VK
S
D
P
V
E
E
A
I
K
F
A
Q
K
I
I
D
----
K
P
I
--
E
P
R
R
I
F
N
K
P
--------
V
P
S
L
P
N
M
D
S
V
F
A
E
--
A
I
A
K
V
R
K
Q
Y
P
G
V
-
L
-
A
P
E
T
C
V
R
S
-
I
Q
A
S
V
K
H
P
Y
E
V
G
I
K
-
E
E
E
K
L
F
M
Y
L
R
A
S
G
Q
A
K
A
L
Q
Y
A
F
F
---
A
E
K
S
-
A
N
K
W
S
T
P
S
G
A
S
W
K
T
A
S
A
Q
P
V
S
S
V
G
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
---
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
L
E
K
E
A
S
R
A
H
Q
N
G
--
Q
A
S
--
A
K
P
K
L
R
F
--
S
S
S
T
K
E
-----
L
-
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
F
F
L
L
E
E
G
-
S
K
P
E
D
V
D
G
V
L
E
E
-
F
G
--
F
K
M
G
P
F
R
V
S
D
----
L
A
G
L
D
V
G
W
K
I
R
K
G
Q
G
----
L
T
G
P
S
L
P
P
GTPVRKRG
N
---
S
R
Y
S
P
L
G
D
M
L
C
E
A
G
R
F
---
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
L
G
R
---
I
H
K
P
D
P
W
L
S
T
F
L
S
Q
Y
R
E
V
H
-----------
H
I
E
----
Q
-----------
R
T
I
S
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
A
A
S
V
------
G
L
P
T
V
L
E
K
L
Q
K
Y
Y
R
Q
N
P
D
IP
Q
L
E
P
S
D
Y
L
R
R
L
V
A
Q
G
S
P
P
--
7
PsiBlast_PDB
69.65
28%
-79
- C1 -
3ZW8
5
ECHP_RAT
A:
[65-724]
-----------------------------------------------------
V
K
A
I
V
I
C
G
A
N
G
N
F
C
A
G
A
D
I
H
G
F
--------
S
A
F
T
P
G
-
L
A
L
G
S
L
V
D
E
I
Q
R
Y
Q
K
P
V
L
A
A
I
Q
G
V
A
L
G
G
G
L
E
L
A
L
G
C
H
Y
R
I
A
--
N
A
K
A
R
V
G
L
P
E
V
T
L
G
I
L
P
G
A
R
G
T
Q
L
L
P
R
V
V
G
V
P
V
A
-
L
D
L
I
T
S
G
K
Y
L
S
A
D
E
A
L
R
L
G
I
L
D
------
A
V
VK
S
D
P
V
E
E
A
I
K
F
A
Q
K
I
I
D
----
K
P
I
--
E
P
R
R
I
F
N
K
P
--------
V
P
S
L
P
N
M
D
S
V
F
A
E
--
A
I
A
K
V
R
K
Q
Y
P
G
V
-
L
-
A
P
E
T
C
V
R
S
-
I
Q
A
S
V
K
H
P
Y
E
V
G
I
K
-
E
E
E
K
L
F
M
Y
L
R
A
S
G
Q
A
K
A
L
Q
Y
A
F
F
---
A
E
K
S
-
A
N
K
W
S
T
P
S
G
A
S
W
K
T
A
S
A
Q
P
V
S
S
V
G
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
---
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
L
E
K
E
A
S
R
A
H
Q
N
G
--
Q
A
S
--
A
K
P
K
L
R
F
--
S
S
S
T
K
E
-----
L
-
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
F
F
L
L
E
E
G
-
S
K
P
E
D
V
D
G
V
L
E
E
-
F
G
--
F
K
M
G
P
F
R
V
S
D
----
L
A
G
L
D
V
G
W
K
I
R
K
G
Q
G
----
L
T
G
P
S
L
P
P
GTPVRKRG
N
---
S
R
Y
S
P
L
G
D
M
L
C
E
A
G
R
F
---
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
L
G
R
---
I
H
K
P
D
P
W
L
S
T
F
L
S
Q
Y
R
E
V
H
-----------
H
I
E
----
Q
-----------
R
T
I
S
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
A
A
S
V
------
G
L
P
T
V
L
E
K
L
Q
K
Y
Y
R
Q
N
P
D
IP
Q
L
E
P
S
D
Y
L
R
R
L
V
A
Q
G
S
P
P
--
9
PsiBlast_PDB
69.39
28%
-79
- C1 -
3ZWA
3
ECHP_RAT
A:
[65-724]
-----------------------------------------------------
V
K
A
I
V
I
C
G
A
N
G
N
F
C
A
G
A
D
I
H
G
F
--------
S
A
F
T
P
G
-
L
A
L
G
S
L
V
D
E
I
Q
R
Y
Q
K
P
V
L
A
A
I
Q
G
V
A
L
G
G
G
L
E
L
A
L
G
C
H
Y
R
I
A
--
N
A
K
A
R
V
G
L
P
E
V
T
L
G
I
L
P
G
A
R
G
T
Q
L
L
P
R
V
V
G
V
P
V
A
-
L
D
L
I
T
S
G
K
Y
L
S
A
D
E
A
L
R
L
G
I
L
D
------
A
V
VK
S
D
P
V
E
E
A
I
K
F
A
Q
K
I
I
D
----
K
P
I
--
E
P
R
R
I
F
N
K
P
--------
V
P
S
L
P
N
M
D
S
V
F
A
E
--
A
I
A
K
V
R
K
Q
Y
P
G
V
-
L
-
A
P
E
T
C
V
R
S
-
I
Q
A
S
V
K
H
P
Y
E
V
G
I
K
-
E
E
E
K
L
F
M
Y
L
R
A
S
G
Q
A
K
A
L
Q
Y
A
F
F
---
A
E
K
S
-
A
N
K
W
S
T
P
S
G
A
S
W
K
T
A
S
A
Q
P
V
S
S
V
G
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
---
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
L
E
K
E
A
S
R
A
H
Q
N
G
--
Q
A
S
--
A
K
P
K
L
R
F
--
S
S
S
T
K
E
-----
L
-
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
F
F
L
L
E
E
G
-
S
K
P
E
D
V
D
G
V
L
E
E
-
F
G
--
F
K
M
G
P
F
R
V
S
D
----
L
A
G
L
D
V
G
W
K
I
R
K
G
Q
G
----
L
T
G
P
S
L
P
P
GTPVRKRG
N
---
S
R
Y
S
P
L
G
D
M
L
C
E
A
G
R
F
---
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
L
G
R
---
I
H
KPD
P
W
L
S
T
F
L
S
Q
Y
R
E
V
H
-----------
H
I
E
----
Q
-----------
R
T
I
S
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
A
A
S
V
------
G
L
P
T
V
L
E
K
L
Q
K
Y
Y
R
Q
N
P
D
IP
Q
L
E
P
S
D
Y
L
R
R
L
V
A
Q
G
S
P
P
--
10
PsiBlast_PDB
69.37
28%
-80
- C1 -
3ZWC
5
ECHP_RAT
A:
[65-724]
-----------------------------------------------------
V
K
A
I
V
I
C
G
A
N
G
N
F
C
A
G
A
D
I
H
G
F
--------
S
A
F
T
P
G
-
L
A
L
G
S
L
V
D
E
I
Q
R
Y
Q
K
P
V
L
A
A
I
Q
G
V
A
L
G
G
G
L
E
L
A
L
G
C
H
Y
R
I
A
--
N
A
K
A
R
V
G
L
P
E
V
T
L
G
I
L
P
G
A
R
G
T
Q
L
L
P
R
V
V
G
V
P
V
A
-
L
D
L
I
T
S
G
K
Y
L
S
A
D
E
A
L
R
L
G
I
L
D
------
A
V
VK
S
D
P
V
E
E
A
I
K
F
A
Q
K
I
I
D
----
K
P
I
--
E
P
R
R
I
F
N
K
P
--------
V
P
S
L
P
N
M
D
S
V
F
A
E
--
A
I
A
K
V
R
K
Q
Y
P
G
V
-
L
-
A
P
E
T
C
V
R
S
-
I
Q
A
S
V
K
H
P
Y
E
V
G
I
K
-
E
E
E
K
L
F
M
Y
L
R
A
S
G
Q
A
K
A
L
Q
Y
A
F
F
---
A
E
K
S
-
A
N
K
W
S
T
P
S
G
A
S
W
K
T
A
S
A
Q
P
V
S
S
V
G
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
---
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
L
E
K
E
A
S
R
A
H
Q
N
G
--
Q
A
S
--
A
K
P
K
L
R
F
--
S
S
S
T
K
E
-----
L
-
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
F
F
L
L
E
E
G
-
S
K
P
E
D
V
D
G
V
L
E
E
-
F
G
--
F
K
M
G
P
F
R
V
S
D
----
L
A
G
L
D
V
G
W
K
I
R
K
G
Q
G
----
L
T
G
P
S
L
P
P
GTPVRKRG
N
---
S
R
Y
S
P
L
G
D
M
L
C
E
A
G
R
F
---
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
L
G
R
---
I
H
KPD
P
W
L
S
T
F
L
S
Q
Y
R
E
V
H
-----------
H
I
E
----
Q
-----------
R
T
I
S
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
A
A
S
V
------
G
L
P
T
V
L
E
K
L
Q
K
Y
Y
R
Q
N
P
D
IP
Q
L
E
P
S
D
Y
L
R
R
L
V
A
Q
G
S
P
P
--
54
PsiBlast_CBE
38.80
34%
-67
- C1 -
1M75
3
HCDH_HUMAN
B:
[16-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
EDI
L
A
K
S
K
K
G
I
E
E
S
L
R
----
K
V
A
K
K
K
F
A
E
--
N
P
K
AG
D
E
F
V
E
K
T
L
S
T
I
A
T
S
T
DAASV
V
-
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
S
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
--
Y
P
M
G
P
F
E
L
L
D
----
Y
V
G
L
D
T
T
K
F
I
V
D
G
-
W
H
E
M
D
A
E
N
---
P
L
--------
H
---
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
----
G
K
K
T
G
E
G
F
Y
K
Y
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
38.51
35%
-65
- C1 -
1F17
1
HCDH_HUMAN
A:
[16-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
F
A
E
N
P
K
A
G
D
E
C
V
--
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
-----
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
--
Y
P
M
G
P
F
E
L
L
D
----
Y
V
G
L
D
T
T
K
F
I
V
D
G
-
W
H
E
M
D
A
E
N
---
P
L
--------
H
---
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
----
G
K
K
T
G
E
G
F
Y
K
Y
K
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
37.85
34%
-68
- C1 -
1M75
3
HCDH_HUMAN
A:
[16-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
----
K
V
A
K
K
K
F
A
E
--
N
P
K
A
G
D
E
F
V
E
K
T
L
S
T
I
A
T
S
T
DAASV
V
-
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
S
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
--
Y
P
M
G
P
F
E
L
L
D
----
Y
V
G
L
D
T
T
K
F
I
V
D
G
-
W
H
E
M
D
A
E
N
---
P
L
--------
H
---
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
----
G
K
K
T
G
E
G
F
Y
K
Y
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
37.58
33%
-66
- C1 -
1F0Y
3
HCDH_HUMAN
B:
[16-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
EDI
L
A
K
S
K
K
G
I
E
E
S
L
R
----
K
V
A
K
K
K
F
A
E
--
N
P
K
AG
D
E
F
V
E
K
T
L
S
T
I
A
T
S
T
DAASV
V
-
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
--
Y
P
M
G
P
F
E
L
L
D
----
Y
V
G
L
D
T
T
K
F
I
V
D
G
-
W
H
E
M
D
A
E
N
---
P
L
--------
H
---
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
----
G
K
K
T
G
E
G
F
Y
K
Y
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
37.30
35%
-65
- C1 -
1F17
1
HCDH_HUMAN
B:
[16-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
EDI
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
F
A
E
N
P
K
A
GD
E
C
V
--
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
-----
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
--
Y
P
M
G
P
F
E
L
L
D
----
Y
V
G
L
D
T
T
K
F
I
V
D
G
-
W
H
E
M
D
A
E
N
---
P
L
--------
H
---
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
----
G
K
K
T
G
E
G
F
Y
K
Y
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
36.20
33%
-71
- C1 -
3HDH
1
HCDH_PIG
A:
[16-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
----
K
V
A
K
K
K
F
A
E
--
N
P
K
A
G
D
E
F
V
E
K
T
L
S
S
I
S
T
S
T
DAASV
V
-
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
S
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
L
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
L
M
K
L
V
E
V
V
K
T
P
M
T
S
Q
K
T
L
E
S
L
V
D
F
S
K
T
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
I
E
A
V
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
--
Y
P
M
G
P
F
E
L
L
D
----
Y
V
G
L
D
T
T
K
F
I
I
D
G
-
W
H
E
M
D
S
Q
N
P
L
F
Q
P
--------
S
---
P
A
---
M
N
K
L
V
A
E
N
K
F
----
G
K
K
T
G
E
G
F
Y
K
Y
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
35.20
33%
-68
- C1 -
1LSO
1
HCDH_HUMAN
B:
[16-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
EDI
L
A
K
S
K
K
G
I
E
E
S
L
R
----
K
V
A
K
K
K
F
A
E
--
N
P
K
AG
D
E
F
V
E
K
T
L
S
T
I
A
T
S
T
DAASV
V
-
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
A
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
--
Y
P
M
G
P
F
E
L
L
D
----
Y
V
G
L
D
T
T
K
F
I
V
D
G
-
W
H
E
M
D
A
E
N
---
P
L
--------
H
---
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
----
G
K
K
T
G
E
G
F
Y
K
Y
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
34.97
35%
-57
- C1 -
4KUG
1
?
A:
[2-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
---
E
E
F
V
D
R
G
I
A
T
I
T
K
S
L
S
K
L
V
A
K
E
K
I
T
E
--
A
D
K
--
E
E
I
L
S
R
I
S
G
T
T
D
M
K
L
-----
A
-
A
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
-
V
A
K
E
E
D
I
D
A
A
M
K
-
L
G
AN
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
E
T
G
-
D
T
K
Y
R
A
S
S
L
-----------------------
L
R
K
Y
V
R
A
GWL
G
R
K
T
G
K
G
F
Y
D
Y
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
34.08
33%
-66
- C1 -
3HDH
1
HCDH_PIG
B:
[16-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
EDI
L
A
K
S
K
K
G
I
E
E
S
L
R
----
K
V
A
K
K
K
F
A
E
--
N
P
K
AG
D
E
F
V
E
K
T
L
S
S
I
S
T
S
T
DAASV
V
-
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
S
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
L
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
L
M
K
L
V
E
V
V
K
T
P
M
T
S
Q
K
T
L
E
S
L
V
D
F
S
K
T
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
I
E
A
V
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
--
Y
P
M
G
P
F
E
L
L
D
----
Y
V
G
L
D
T
T
K
F
I
I
D
G
-
W
H
E
M
D
S
Q
N
P
L
F
Q
P
--------
S
---
P
A
---
M
N
K
L
V
A
E
N
K
F
----
G
K
K
T
G
E
G
F
Y
K
Y
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
32.84
35%
-54
- C1 -
4KUG
1
?
C:
[2-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
---
E
E
F
V
D
R
G
I
A
T
I
T
K
S
L
S
K
L
V
A
K
E
K
I
T
E
--
A
D
K
--
E
E
I
L
S
R
I
S
G
T
T
D
M
K
L
-----
A
-
A
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
-
V
A
K
E
E
D
I
D
A
A
M
K
-
L
G
AN
H
P
M
G
P
L
A
L
G
D
LIGL
D
V
C
L
A
I
M
D
V
L
Y
N
E
T
G
-
D
T
K
Y
R
A
S
S
L
-----------------------
L
R
K
Y
V
R
A
GWL
G
R
K
T
G
K
G
F
Y
D
Y
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
31.83
35%
-54
- C1 -
4KUG
1
?
B:
[2-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
---
E
E
F
V
D
R
G
I
A
T
I
T
K
S
L
S
K
L
V
A
K
E
K
I
T
E
--
A
D
K
--
E
E
I
L
S
R
I
S
G
T
T
D
M
K
L
-----
A
-
A
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
-
V
A
K
E
E
D
I
D
A
A
M
K
-
L
G
AN
H
P
M
G
P
L
A
L
G
D
LIGL
D
V
C
L
A
I
M
D
V
L
Y
N
E
T
G
-
D
T
K
Y
R
A
S
S
L
-----------------------
L
R
K
Y
V
R
A
GWL
G
R
K
T
G
K
G
F
Y
D
Y
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
30.75
35%
-54
- C1 -
4KUG
1
?
D:
[2-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
---
E
E
F
V
D
R
G
I
A
T
I
T
K
S
L
S
K
L
V
A
K
E
K
I
T
E
--
A
D
K
--
E
E
I
L
S
R
I
S
G
T
T
D
M
K
L
-----
A
-
A
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
-
V
A
K
E
E
D
I
D
A
A
M
K
-
L
G
AN
H
P
M
G
P
L
A
L
G
D
LIGL
D
V
C
L
A
I
M
D
V
L
Y
N
E
T
G
-
D
T
K
Y
R
A
S
S
L
-----------------------
L
R
K
Y
V
R
A
GWL
G
R
K
T
G
K
G
F
Y
D
Y
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------