@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA1787: (2016-02-01 )
MLEAYRKHVEERAAQGVVPQPLNAEQTAGLVELLKNPPAGEEEFLLDLITNRVPPGVDEAAYVKAGFLSAIVKGEATSPLIDKQRAAELLGTMQGGYNIATLVELLDDAELANTAAEQLKHTLLMFDAFHDVAERAKKGNAAAKSVLQSWADGEWFKAKPEVPEKLTLTVFKVPGETNTDDLSPAPDAWSRPDIPLHALAMLKMARDGIEPVQPGSVGPLKQIEAVKAKGFPVAYVGDVVGTGSSRKSATNSVLWFFGDDIPFVPNKRAGGFCFGTKIAPIFYNTMEDAGALPIEFDCTNLAMGDVIDVYPYEGKVVRHDSGEVVTTFELKTPVLLDEVRAGGRIPLIVGRGLTEKARAELGLGASDLFRKPEAPADSGKGFTLAQKMVGRACGLPEGQGVRPGTYCEPKMTTVGSQDTTGPMTRDELKDLACLGFSADLVMQSFCHTAAYPKPIDVKTHHTLPDFIMTRGGVSLRPGDGIIHSWLNRMLLPDTVGTGGDSHTRFPIGISFPAGSGLVAFAAATGVMPLDMPESVLVRFKGKLQPGITLRDLVHAIPYYAIQQGLLTVEKKGKKNIFSGRILEIEGLNDLTVEQAFELSDASAERSAAGCTIKLPEQAIAEYLKSNITLLRWMIGEGYGDPRTLERRAQAMEAWLAKPELLEADKDAEYAAVIEIDLADVKEPVLCAPNDPDDARLLSSVQGRKIDEVFIGSCMTNIGHFRAAGKLLDKVKGGIPTRLWLAPPTKMDAHQLTEEGYYGIYGKAGARMEMPGCSLCMGNQARVQTGSTVVSTSTRNFPNRLGDATDVFLASAELAAVSSILGKLPTVEEYMAYAKDIDSMAADVYRYLSFDQIAEFREAAANAKIPVVQA
Atome Classification :
(20 SA)
-.........10........20........30.--.......40.......--.50........-60........70.----------.......80........90...--------.....100.----......110.......120.......130.......140.......150.----......160.......170...-------.....180.......190....----....200---------...--....210.......220...-....230--.......240.......250...-------------------....260.....---..270........280.......290.....--.---.---------300-........310.....-----..320..----.....330.......340----.......350.......360.......370.......380---.......390.......400-------------------....-.-....410.......420.......430---.-..-....440-----..-...---------.------.---.450..------...----..460------..--------.....-470--...----.--....480..----.-.--..-----------.490------........500---..-------....--.---.-510.-....--.-----------------.520....-.---..-------530-........540.......550....---------...560-..--.....570......-----.580..--.--....590.-......600.-......610.......620.......630.......640.....----------..650.......660---..--...-...670--------------.......680--------.........690.......700---------.-------.---------------------------------------.-....--------.----------------------------.710.--.-----.-.-...720.......-730--.--.---...--.----..--.740.......750-.......760.......770.....----..780------.-.-..--------.--.---..---.790.......800--...-.-...810.......820---.-------...-----...830-----------.....------..840....---------------...850.......860.......---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-M
L
E
A
Y
R
K
H
V
E
E
R
A
AQGVVPQPL
N
A
E
Q
T
A
G
L
V
E
--
L
LKNPPA
G
E
E
E
F
L
L
D
L
--
I
TNRVPPGVD
E
-
A
A
Y
V
K
A
G
F
L
S
A
I
V
----------KGEATSP
L
I
D
K
Q
R
A
A
E
L
L
G
T
MQ--------GG
Y
N
I
A
T
L
V
----
E
L
LD
D
A
E
L
A
N
T
A
A
E
Q
L
K
H
T
L
L
M
F
D
A
F
H
D
V
A
E
R
A
KKG
N
A
A
A
K
S
V
L
Q
S
WADG----EWFKAKPEVP
E
K
L
T
L
T
V
-
F
KVP-------GETNTDDLSPAPDAWSR-PD
I
P
----
L
H
A
L
A
M
L
---------
K
M
A
--RDGIEPVQPGSVG
P
L
K
Q
I
E
A
-VKAKG
F
P
--
V
A
Y
V
GDVVGTGSSRKSATN
S
V
L
W
-------------------
F
FGDDIPFVPNK---RAG-
G
F
C
FG
T
K
I
A
P
I
F
Y
NTMEDAGA
L
P
I
E
F
D--C---T---------NL--AMG
D
V
I
D
VYPYE
G
K
V
V
-----RHDSG
E
V
----
V
T
T
F
ELKT
P
V
L
L
D
E
VRAG----GR
I
P
L
I
VGRGL
T
E
K
A
R
A
ELGL
G
A
S
D
L
FRKPEAPADSGK
G
F
---
T
L
A
Q
K
M
V
G
RACGLPEGQG---------------------VRPG-T-YCEPK
M
T
TVGSQDTTGPM
T
R
D
E
L
K
D
L
A
---C-LG-F
S
A
D
L
V
------
M
Q
-
S
F
C
---------H------T---AAYPKP------IDV----KTHHT------
L
P
--------
D
F
I
M
T-RG---GVS----L--RPG
D
G
I
I
H
S
----
W
-
L
--NR-----------MLL-------PDTVGTGGDS----H
T
-------
R
F
P
I
--
G
---
I
-SFPA-GSG
L
--
V
-----------------
A
F
A
AATGV-M---PL-------DM--
P
E
S
V
L
V
R
FKGKLQPG
I
T
L
R
D
L
V
H
AI---------
P
Y
Y
A
I
Q
-
Q
G
--
L
L
T
V
E
KKGKKNIFS-----
G
R
I
L
E
I
--E--GLND
L
T
V
E
-
Q
A
FELSDASA-ERSAAG
C
T
I
KL
P
E
Q
A
I
A
E
Y
L
K
S
N
I
T
L
L
R
W
M
I
GEGYGD
P
R
T
L
E
R
R
----------
A
Q
A
M
E
A
W
LAKPELL----EA--DKD-A
E
Y
A
A
V
--------------
I
E
I
DLADV----------KE
P
V
L
CAPNDP
D
D
A
R
L
L
S
S
V-----------Q-------G---------------------------------------R-K
I
D
E
--------
V
----------------------------
F
I
G
S
C
--
M
-----
T
-N-IG
H
F
R
A
A
G
K
L
L
D
K
-
V
----K--G---GI
P
--
T
----
R
L
--WLAPPTKM
D
A
H
Q
L
T
-EEGY
Y
G
I
YGKAGARMEMPGCSLCMG----NQ
A
--------
R
-V-QT--------G--
S
---
T
V
---
V
STSTRNF
P
N
RLGD--
A
T
D
-
V
-
F
L
A
S
A
E
L
A
A
V
S
S
I
L
GK---L-------P
T
V
-----
E
E
Y
M
A
Y
-----------
A
K
D
I
D
------
S
M
A
A
D
V
Y
R
Y---------------L
S
F
D
Q
I
A
E
F
R
E
AAANAKIPVVQA---
22
Fugue
99.00
78%
-82
- C2 -
1L5J
2
ACNB_ECOLI
A:
[1-862]
-
M
L
E
E
Y
R
K
H
V
A
E
R
A
A
E
G
I
A
P
K
P
L
D
A
N
Q
M
A
A
L
V
E
--
L
L
K
N
P
P
A
G
E
E
E
F
L
L
D
L
--
L
T
N
R
V
P
P
G
V
D
E
-
A
A
Y
V
K
A
G
F
L
A
A
I
A
----------
K
G
E
A
K
S
P
L
L
T
P
E
K
A
I
E
L
L
G
T
M
Q
--------
G
G
Y
N
I
H
P
L
I
----
D
A
L
D
D
A
K
L
A
P
I
A
A
K
A
L
S
H
T
L
L
M
F
D
N
F
Y
D
V
E
E
K
A
K
A
G
N
E
Y
A
K
Q
V
M
Q
S
W
A
D
A
----
E
W
F
L
N
R
P
A
L
A
E
K
L
T
V
T
V
-
F
K
V
T
-------
G
E
T
N
T
D
D
L
S
P
A
P
D
A
W
S
R
-
P
D
I
P
----
L
H
A
L
A
M
L
---------
K
N
A
--
R
E
G
I
E
P
D
Q
P
G
V
V
G
P
I
K
Q
I
E
A
-
L
Q
Q
K
G
F
P
--
L
A
Y
V
G
D
V
V
G
T
G
S
S
R
K
S
A
T
N
S
V
L
W
-------------------
F
M
G
D
D
I
P
H
V
P
N
K
---
R
G
G
-
G
L
C
L
G
G
K
I
A
P
I
F
F
N
T
M
E
D
A
G
A
L
P
I
E
V
D
--
V
---
S
---------
N
L
--
N
M
G
D
V
I
D
V
Y
P
Y
K
G
E
V
R
-----
N
H
E
T
G
E
L
----
L
A
T
F
E
L
K
T
D
V
L
I
D
E
V
R
A
G
----
G
R
I
P
L
I
I
G
R
G
L
T
T
K
A
R
E
A
L
G
L
P
H
S
D
V
F
R
Q
A
K
D
V
A
E
S
D
R
G
F
---
S
L
A
Q
K
M
V
G
R
A
C
G
V
K
G
------------------------
I
R
P
G
-
A
-
Y
C
E
P
K
M
T
S
V
G
S
Q
D
T
T
G
P
M
T
R
D
E
L
K
D
L
A
---
C
-
L
G
-
F
S
A
D
L
V
------
M
Q
-
S
F
C
---------
H
------
T
---
A
A
Y
P
K
P
------
V
D
V
----
N
T
H
H
T
------
L
P
--------
D
F
I
M
N
-
R
G
---
G
V
S
----
L
--
R
P
G
D
G
V
I
H
S
----
W
-
L
--
N
R
-----------
M
L
L
-------
P
D
T
V
G
T
G
G
D
S
----
H
T
-------
R
F
P
I
--
G
---
I
-
S
F
P
A
-
G
S
G
L
--
V
-----------------
A
F
A
A
A
T
G
V
-
M
---
P
L
-------
D
M
--
P
E
S
V
L
V
R
F
K
G
K
M
Q
P
G
I
T
L
R
D
L
V
H
A
I
---------
P
L
Y
A
I
K
-
Q
G
--
L
L
T
V
E
K
K
G
K
K
N
I
F
S
-----
G
R
I
L
E
I
--
E
--
G
L
P
D
L
K
V
E
-
Q
A
F
E
L
T
D
A
S
A
-
E
R
S
A
A
G
C
T
I
K
L
N
K
E
P
I
I
E
Y
L
N
S
N
I
V
L
L
K
W
M
I
A
E
G
Y
G
D
R
R
T
L
E
R
R
----------
I
Q
G
M
E
K
W
L
A
N
P
E
L
L
----
E
A
--
D
A
D
-
A
E
Y
A
A
V
--------------
I
D
I
D
L
A
D
I
----------
K
E
P
I
L
C
A
P
N
D
P
D
D
A
R
P
L
S
A
V
-----------
Q
-------
G
---------------------------------------
E
-
K
I
D
E
--------
V
----------------------------
F
I
G
S
C
--
M
-----
T
-
N
-
I
G
H
F
R
A
A
G
K
L
L
D
A
-
H
----
K
--
G
---
Q
L
P
--
T
----
R
L
--
W
V
A
P
P
T
R
M
D
A
A
Q
L
T
-
E
E
G
Y
Y
S
V
F
G
K
S
G
A
R
I
E
I
P
G
C
S
L
C
M
G
----
N
Q
A
--------
R
-
V
-
A
D
--------
G
--
A
---
T
V
---
V
S
T
S
T
R
N
F
P
N
R
L
G
T
--
G
A
N
-
V
-
F
L
A
S
A
E
L
A
A
V
A
A
L
I
G
K
---
L
-------
P
T
P
-----
E
E
Y
Q
T
Y
-----------
V
A
Q
V
D
------
K
T
A
V
D
T
Y
R
Y
---------------
L
N
F
N
Q
L
S
Q
Y
T
E
K
A
D
G
V
I
F
Q
-------
1
PsiBlast_PDB
98.68
79%
-82
- C2 -
1L5J
2
ACNB_ECOLI
A:
[1-856]
-
M
L
E
E
Y
R
K
H
V
A
E
R
A
A
E
G
I
A
P
K
P
L
D
A
N
Q
M
A
A
L
V
E
--
L
L
K
N
P
P
A
G
E
E
E
F
L
L
D
L
--
L
T
N
R
V
P
P
G
V
D
E
-
A
A
Y
V
K
A
G
F
L
A
A
I
A
----------
K
G
E
A
K
S
P
L
L
T
P
E
K
A
I
E
L
L
G
T
M
Q
--------
G
G
Y
N
I
H
P
L
I
----
D
A
L
D
D
A
K
L
A
P
I
A
A
K
A
L
S
H
T
L
L
M
F
D
N
F
Y
D
V
E
E
K
A
K
A
G
N
E
Y
A
K
Q
V
M
Q
S
W
A
D
A
----
E
W
F
L
N
R
P
A
L
A
E
K
L
T
V
T
V
-
F
K
V
T
-------
G
E
T
N
T
D
D
L
S
P
A
P
D
A
W
S
R
-
P
D
I
P
----
L
H
A
L
A
M
L
---------
K
N
A
--
R
E
G
I
E
P
D
Q
P
G
V
V
G
P
I
K
Q
I
E
A
-
L
Q
Q
K
G
F
P
--
L
A
Y
V
G
D
V
V
G
T
G
S
S
R
K
S
A
T
N
S
V
L
W
-------------------
F
M
G
D
D
I
P
H
V
P
N
K
---
R
G
G
-
G
L
C
L
G
G
K
I
A
P
I
F
F
N
T
M
E
D
A
G
A
L
P
I
E
V
D
--
V
---
S
---------
N
L
--
N
M
G
D
V
I
D
V
Y
P
Y
K
G
E
V
R
-----
N
H
E
T
G
E
L
----
L
A
T
F
E
L
K
T
D
V
L
I
D
E
V
R
A
G
----
G
R
I
P
L
I
I
G
R
G
L
T
T
K
A
R
E
A
L
G
L
P
H
S
D
V
F
R
Q
A
K
D
V
A
E
S
D
R
G
F
---
S
L
A
Q
K
M
V
G
R
A
C
G
V
---
K
G
---------------------
I
R
P
G
-
A
-
Y
C
E
P
K
M
T
S
V
G
S
Q
D
T
T
G
P
M
T
R
D
E
L
K
D
L
A
---
C
-
L
G
-
F
S
A
D
L
V
------
M
Q
-
S
F
C
---------
H
------
T
---
A
A
Y
P
K
P
------
V
D
V
----
N
T
H
H
T
------
L
P
--------
D
F
I
M
N
-
R
G
---
G
V
S
----
L
--
R
P
G
D
G
V
I
H
S
----
W
-
L
--
N
R
-----------
M
L
L
-------
P
D
T
V
G
T
G
G
D
S
----
H
T
-------
R
F
P
I
--
G
---
I
-
S
F
P
A
-
G
S
G
L
--
V
-----------------
A
F
A
A
A
T
G
V
-
M
---
P
L
-------
D
M
--
P
E
S
V
L
V
R
F
K
G
K
M
Q
P
G
I
T
L
R
D
L
V
H
A
I
---------
P
L
Y
A
I
K
-
Q
G
--
L
L
T
V
E
K
K
G
K
K
N
I
F
S
-----
G
R
I
L
E
I
--
E
--
G
L
P
D
L
K
V
E
-
Q
A
F
E
L
T
D
A
S
A
-
E
R
S
A
A
G
C
T
I
K
L
N
K
E
P
I
I
E
Y
L
N
S
N
I
V
L
L
K
W
M
I
A
E
G
Y
G
D
R
R
T
L
E
R
R
----------
I
Q
G
M
E
K
W
L
A
N
P
E
L
L
----
E
A
--
D
A
D
-
A
E
Y
A
A
V
--------------
I
D
I
D
L
A
D
I
----------
K
E
P
I
L
C
A
P
N
D
P
D
D
A
R
P
L
S
A
V
-----------
Q
-------
G
---------------------------------------
E
-
K
I
D
E
--------
V
----------------------------
F
I
G
S
C
--
M
-----
T
-
N
-
I
G
H
F
R
A
A
G
K
L
L
D
A
-
H
----
K
--
G
---
Q
L
P
--
T
----
R
L
--
W
V
A
P
P
T
R
M
D
A
A
Q
L
T
-
E
E
G
Y
Y
S
V
F
G
K
S
G
A
R
I
E
I
P
G
C
S
L
C
M
G
----
N
Q
A
--------
R
-
V
-
A
D
--------
G
--
A
---
T
V
---
V
S
T
S
T
R
N
F
P
N
R
L
G
T
--
G
A
N
-
V
-
F
L
A
S
A
E
L
A
A
V
A
A
L
I
G
K
---
L
-------
P
T
P
-----
E
E
Y
Q
T
Y
-----------
V
A
Q
V
D
------
K
T
A
V
D
T
Y
R
Y
---------------
L
N
F
N
Q
L
S
Q
Y
T
E
K
A
D
G
V
I
F
Q
-------
10
PsiBlast_CBE
98.42
79%
-80
- C2 -
1L5J
2
ACNB_ECOLI
B:
[1-856]
-
M
L
E
E
Y
R
K
H
V
A
E
R
A
A
E
G
I
A
P
K
P
L
D
A
N
Q
M
A
A
L
V
E
--
L
L
K
N
P
P
A
G
E
E
E
F
L
L
D
L
--
L
T
N
R
V
P
P
G
V
D
E
-
A
A
Y
V
K
A
G
F
L
A
A
I
A
----------
K
G
E
A
K
S
P
L
L
T
P
E
K
A
I
E
L
L
G
T
M
Q
--------
G
G
Y
N
I
H
P
L
I
----
D
A
L
D
D
A
K
L
A
P
I
A
A
K
A
L
S
H
T
L
L
M
F
D
N
F
Y
D
V
E
E
K
A
K
A
G
N
E
Y
A
K
Q
V
M
Q
S
W
A
D
A
----
E
W
F
L
N
R
P
A
L
A
E
K
L
T
V
T
V
-
F
K
V
T
-------
G
E
T
N
T
D
D
L
S
P
A
P
D
A
W
S
R
-
P
D
I
P
----
L
H
A
L
A
M
L
---------
K
N
A
--
R
E
G
I
E
P
D
Q
P
G
V
V
G
P
I
K
Q
I
E
A
-
L
Q
Q
K
G
F
P
--
L
A
Y
V
G
D
V
V
G
T
G
S
S
R
K
S
A
T
N
S
V
L
W
-------------------
F
M
G
D
D
I
P
H
V
P
N
K
---
R
G
G
-
G
L
C
L
G
G
K
I
A
P
I
F
F
N
T
M
E
D
A
G
A
L
P
I
E
V
D
--
V
---
S
---------
N
L
--
N
M
G
D
V
I
D
V
Y
P
Y
K
G
E
V
R
-----
N
H
E
T
G
E
L
----
L
A
T
F
E
L
K
T
D
V
L
I
D
E
V
R
A
G
----
G
R
I
P
L
I
I
G
R
G
L
T
T
K
A
R
E
A
L
G
L
P
H
S
D
V
F
R
Q
A
K
D
V
A
E
S
D
R
G
F
---
S
L
A
Q
K
M
V
G
R
A
C
G
V
---
K
G
---------------------
I
R
P
G
-
A
-
Y
C
E
P
K
M
T
S
V
G
S
Q
D
T
T
G
P
M
T
R
D
E
L
K
D
L
A
---
C
-
L
G
-
F
S
A
D
L
V
------
M
Q
-
S
F
C
---------
H
------
T
---
A
A
Y
P
K
P
------
V
D
V
----
N
T
H
H
T
------
L
P
--------
D
F
I
M
N
-
R
G
---
G
V
S
----
L
--
R
P
G
D
G
V
I
H
S
----
W
-
L
--
N
R
-----------
M
L
L
-------
P
D
T
V
G
T
G
G
D
S
----
H
T
-------
R
F
P
I
--
G
---
I
-
S
F
P
A
-
G
S
G
L
--
V
-----------------
A
F
A
A
A
T
G
V
-
M
---
P
L
-------
D
M
--
P
E
S
V
L
V
R
F
K
G
K
M
Q
P
G
I
T
L
R
D
L
V
H
A
I
---------
P
L
Y
A
I
K
-
Q
G
--
L
L
T
V
E
K
K
G
K
K
N
I
F
S
-----
G
R
I
L
E
I
--
E
--
G
L
P
D
L
K
V
E
-
Q
A
F
E
L
T
D
A
S
A
-
E
R
S
A
A
G
C
T
I
K
L
N
K
E
P
I
I
E
Y
L
N
S
N
I
V
L
L
K
W
M
I
A
E
G
Y
G
D
R
R
T
L
E
R
R
----------
I
Q
G
M
E
K
W
L
A
N
P
E
L
L
----
E
A
--
D
A
D
-
A
E
Y
A
A
V
--------------
I
D
I
D
L
A
D
I
----------
K
E
P
I
L
C
A
P
N
D
P
D
D
A
R
P
L
S
A
V
-----------
Q
-------
G
---------------------------------------
E
-
K
I
D
E
--------
V
----------------------------
F
I
G
S
C
--
M
-----
T
-
N
-
I
G
H
F
R
A
A
G
K
L
L
D
A
-
H
----
K
--
G
---
Q
L
P
--
T
----
R
L
--
W
V
A
P
P
T
R
M
D
A
A
Q
L
T
-
E
E
G
Y
Y
S
V
F
G
K
S
G
A
R
I
E
I
P
G
C
S
L
C
M
G
----
N
Q
A
--------
R
-
V
-
A
D
--------
G
--
A
---
T
V
---
V
S
T
S
T
R
N
F
P
N
R
L
G
T
--
G
A
N
-
V
-
F
L
A
S
A
E
L
A
A
V
A
A
L
I
G
K
---
L
-------
P
T
P
-----
E
E
Y
Q
T
Y
-----------
V
A
Q
V
D
------
K
T
A
V
D
T
Y
R
Y
---------------
L
N
F
N
Q
L
S
Q
Y
T
E
K
A
D
G
V
I
F
Q
-------
11
HHSearch
98.25
78%
-80
- C2 -
1L5J
2
ACNB_ECOLI
A:
[1-861]
-
M
L
E
E
Y
R
K
H
V
A
E
R
A
A
E
G
I
A
P
K
P
L
D
A
N
Q
M
A
A
L
V
E
--
L
L
K
N
P
P
A
G
E
E
E
F
L
L
D
L
--
L
T
N
R
V
P
P
G
V
D
E
-
A
A
Y
V
K
A
G
F
L
A
A
I
A
----------
K
G
E
A
K
S
P
L
L
T
P
E
K
A
I
E
L
L
G
T
M
Q
--------
G
G
Y
N
I
H
P
L
I
----
D
A
L
D
D
A
K
L
A
P
I
A
A
K
A
L
S
H
T
L
L
M
F
D
N
F
Y
D
V
E
E
K
A
K
A
G
N
E
Y
A
K
Q
V
M
Q
S
W
A
D
A
----
E
W
F
L
N
R
P
A
L
A
E
K
L
T
V
T
V
-
F
K
V
T
-------
G
E
T
N
T
D
D
L
S
P
A
P
D
A
W
S
R
-
P
D
I
P
L
H
A
L
A
M
L
K
N
A
R
---------
E
G
I
--
E
P
D
Q
----
P
G
V
V
G
P
I
K
Q
I
E
A
-
L
Q
Q
K
G
F
P
--
L
A
Y
V
G
D
V
V
G
T
G
S
S
R
K
S
A
T
N
S
V
L
W
-------------------
F
M
G
D
D
I
P
H
V
P
N
K
---
R
G
G
-
G
L
C
L
G
G
K
I
A
P
I
F
F
N
T
M
E
D
A
G
A
L
P
I
E
V
D
--
V
---
S
---------
N
L
--
N
M
G
D
V
I
D
V
Y
P
Y
K
G
E
V
R
-----
N
H
E
T
G
E
L
----
L
A
T
F
E
L
K
T
D
V
L
I
D
E
V
R
A
G
----
G
R
I
P
L
I
I
G
R
G
L
T
T
K
A
R
E
A
L
G
L
P
H
S
D
V
F
R
Q
A
K
D
V
A
E
S
D
R
G
F
---
S
L
A
Q
K
M
V
G
R
A
C
G
V
K
---
G
---------------------
I
R
P
G
-
A
-
Y
C
E
P
K
M
T
S
V
G
S
Q
D
T
T
G
P
M
T
R
D
E
L
K
D
L
A
---
C
-
L
G
-
F
S
A
D
L
V
------
M
Q
-
S
F
C
---------
H
------
T
---
A
A
Y
P
K
P
------
V
D
V
----
N
T
H
H
T
------
L
P
--------
D
F
I
M
N
-
R
G
---
G
V
S
----
L
--
R
P
G
D
G
V
I
H
S
----
W
-
L
--
N
R
-----------
M
L
L
-------
P
D
T
V
G
T
G
G
D
S
----
H
T
-------
R
F
P
I
--
G
---
I
-
S
F
P
A
-
G
S
G
L
--
V
-----------------
A
F
A
A
A
T
G
V
-
M
---
P
L
-------
D
M
--
P
E
S
V
L
V
R
F
K
G
K
M
Q
P
G
I
T
L
R
D
L
V
H
A
I
---------
P
L
Y
A
I
K
-
Q
G
--
L
L
T
V
E
K
K
G
K
K
N
I
F
S
-----
G
R
I
L
E
I
--
E
--
G
L
P
D
L
K
V
E
-
Q
A
F
E
L
T
D
A
S
A
-
E
R
S
A
A
G
C
T
I
K
L
N
K
E
P
I
I
E
Y
L
N
S
N
I
V
L
L
K
W
M
I
A
E
G
Y
G
D
R
R
T
L
E
R
R
----------
I
Q
G
M
E
K
W
L
A
N
P
E
L
L
----
E
A
--
D
A
D
-
A
E
Y
A
A
V
--------------
I
D
I
D
L
A
D
I
----------
K
E
P
I
L
C
A
P
N
D
P
D
D
A
R
P
L
S
A
V
-----------
Q
-------
G
---------------------------------------
E
-
K
I
D
E
--------
V
----------------------------
F
I
G
S
C
--
M
-----
T
-
N
-
I
G
H
F
R
A
A
G
K
L
L
D
A
-
H
----
K
--
G
---
Q
L
P
--
T
----
R
L
--
W
V
A
P
P
T
R
M
D
A
A
Q
L
T
-
E
E
G
Y
Y
S
V
F
G
K
S
G
A
R
I
E
I
P
G
C
S
L
C
M
G
----
N
Q
A
--------
R
-
V
-
A
D
--------
G
--
A
---
T
V
---
V
S
T
S
T
R
N
F
P
N
R
L
G
T
--
G
A
N
-
V
-
F
L
A
S
A
E
L
A
A
V
A
A
L
I
G
K
---
L
-------
P
T
P
-----
E
E
Y
Q
T
Y
-----------
V
A
Q
V
D
------
K
T
A
V
D
T
Y
R
Y
---------------
L
N
F
N
Q
L
S
Q
Y
T
E
K
A
D
G
V
I
F
Q
-------
23
Fugue
73.15
85%
-93
* C2 *
1L5J
2
ACNB_ECOLI
A:
[380-822]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
F
---
S
L
A
Q
K
M
V
G
R
A
C
G
V
---
K
G
---------------------
I
R
P
G
-
A
-
Y
C
E
P
K
M
T
S
V
G
S
Q
D
T
T
G
P
M
T
R
D
E
L
K
D
L
A
---
C
-
L
G
-
F
S
A
D
L
V
------
M
Q
-
S
F
C
---------
H
TAAYPK---------
P
------
V
D
V
----
N
T
H
H
T
------
L
P
--------
D
F
I
M
N
-
R
G
---
G
V
S
----
L
--
R
P
G
D
G
V
I
H
S
----
W
-
L
--
N
R
------------
M
L
L------
P
D
T
V
G
T
G
G
D
S
----
H
T
-------
R
--
F
P
I
G
---
I
-
S
F
P
A
-
G
S
G
L
--
V
-----------------
A
F
A
A
A
T
G
V
-
M
---
P
L
-------
D
M
--
P
E
S
V
L
V
R
F
K
G
K
M
Q
P
G
I
T
L
R
D
L
V
H
A
I
---------
P
L
Y
A
I
K
-
Q
G
--
L
L
T
V
E
K
K
G
K
K
N
I
F
S
-----
G
R
I
L
E
I
E
G----
L
P
D
L
K
V
E
-
Q
A
F
E
L
T
D
A
S
A
-
E
R
S
A
A
G
C
T
I
K
L
N
K
E
P
I
I
E
Y
L
N
S
N
I
V
L
L
K
W
M
I
A
E
G
Y
G
D
R
R
T
L
E
R
R
----------
I
Q
G
M
E
K
W
L
A
N
P
E
L
L
----
E
A
--
D
A
D
-
A
E
Y
A
A
V
--------------
I
D
I
D
L
A
D
I
----------
K
E
P
I
L
C
A
P
N
D
P
D
D
A
R
P
L
S
A
V
-----------
Q
-------
G
----------------------------------------E
K
I
D
E
--------
V
----------------------------
F
I
G
S
C
--
M
-------
T
N
I
G
H
F
R
A
A
G
K
L
L
D
A
----------
H
KG
Q
L
P
--
T
----
R
L
--
W
V
A
P
P
T
R
M
D
A
A
Q
L
T
-
E
E
G
Y
Y
S
V
F
G
K
S
G
A
R
I
E
I
P
G
C
S
L
C
M
G
----
N
Q
A
--------
R
----
V
--------
A
DG
A
---
T
V
---
V
S
T
S
T
R
N
F
P
N
R
L
G
T
--
G
A
N
-
V
-
F
L
A
S
A
E
L
A
A
V
A
A
L
I
G
K
---
L
-------
P
T
P
-----
E
E
Y
Q
T
Y
-----------
V
A
Q
V
D
------
K
T
A
V
D
T
Y
R
Y
---------------
L
N
F
N
Q
L
S
Q
Y
T
E
K
A
D
G
V
I
F
Q
-------
3
PsiBlast_PDB
55.01
25%
-52
- C2 -
4KP2
-
HACA_METJA
A:
[22-436]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
---
T
L
V
E
K
I
L
S
K
K
V
G
Y
E
-------------------------
V
C
A
G
-
D
-
S
I
E
V
E
V
D
L
A
M
T
H
D
G
T
T
P
L
A
Y
K
A
L
K
E
M
S
---
D
-
S
V
-
W
N
P
D
K
I
------
V
V
-
A
F
D
---------
H
------
N
---
V
P
-
P
N
T
------
V
K
A
----
A
E
M
Q
K
------
L
A
--------
L
E
F
V
K
-
R
F
---
G
I
K
NF--
H
--
K
G
G
E
G
I
C
H
Q
----
I
-
L
A
-
E
N
-----------
Y
V
L
-------
P
N
M
F
V
A
G
G
D
S
----
H
T
-------
C
T
H
G
--
A
---
F
G
A
F
A
T
-
G
F
G
A
T
D
M
-----------------
A
Y
I
Y
A
T
G
E
-
T
---
W
I
-------
K
V
--
P
K
T
I
R
V
D
I
V
G
K
-
N
E
N
V
S
A
K
D
I
V
L
R
V
---------
C
K
E
I
G
R
-
R
G
AT
Y
M
A
I
E
Y
G
G
-------------------
E
--
V
V
K
N
M
D
M
D
-
G
R
L
T
L
C
N
M
A
I
-
E
M
G
G
K
T
G
V
I
E
-
A
D
E
I
T
Y
D
Y
L
K
K
-------------------
E
R
G
----------
L
S
D
E
D
I
A
K
L
K
K
E
R
I
----
T
V
--
N
R
D
E
A
N
Y
Y
K
E
--------------
I
E
I
D
I
T
D
M
----------
E
E
Q
V
-
A
V
P
H
H
P
D
N
V
K
P
I
S
D
V
-----------
E
-------
G
---------------------------------------
T
-
E
I
N
Q
--------
V
----------------------------
F
I
G
S
C
--
T
-----
N
G
R
-
L
S
D
L
R
E
A
A
K
Y
L
K
G
-
R
----
E
--
V
---
H
K
D
--
V
----
K
L
--
I
V
I
P
A
S
K
K
V
F
L
Q
A
L
-
K
E
G
I
I
D
I
F
V
K
A
G
A
M
I
C
T
P
G
C
G
P
C
L
G
A---
H
Q
G
--------
V
-
L
-
A
E
--------
G
--
E
---
I
C
---
L
S
T
T
N
R
N
F
K
G
R
M
G
H
--
I
N
S
Y
I
-
Y
L
A
S
P
K
I
A
A
I
S
A
V
K
G
Y
---
I
-------
T
N
K
-----------------------------------------------------------------------------------
12
HHSearch
54.40
22%
-60
- C2 -
1C96
3
ACON_BOVIN
A:
[30-482]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
N
R
P
L
---
T
L
S
E
K
I
V
Y
G
H
L
D
D
P
A
N
Q
E
---------------------
I
E
R
G
-
K
T
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
---
L
P
K
V
-
A
V
P
S
T
I
---------
H
C
D
---------
H
------
L
---
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
------
L
A
--------
T
A
G
A
K
-
Y
G
---
V
G
F
----
W
--
R
P
G
S
G
I
I
H
Q
----
I
-
I
--
L
E
N----------
Y
A
Y
-------
P
G
V
L
L
I
G
T
D
S
----
H
T
-------
P
N
G
G
--
G
LG
G
I
-
C
I
G
V
-
G
G
A
D
--
A
-----------------
V
D
V
M
A
G
I
P
-
W
---
E
L
-------
K
C
--
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
-------------
A
G
-
I
L
----------
T
V
K
G
G
T
-----
G
A
I
V
E
Y
--
H
G
P
G
V
D
S
I
S
C
T
-
G
M
A
T
I
C
N
M
G
A
-
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
-
K
K
Y
L
S
K
T
----------
G
R
A
D
I
A
N
----------------
L
A
D
E
F
---
K
D
H
L
----
V
P
--
D
P
G
-
C
H
Y
D
Q
V
--------------
I
E
I
N
L
S
E
L
-----------
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
-----------
G
S
V
A
E
K
E
G
W
P--------------------------------------
L
-
D
I
R
V
--------
G
----------------------------
L
I
G
S
C
--
T
-----
N
-
S
S
Y
E
D
M
G
R
S
A
A
V
A
K
Q
-
A
L
A
H
-
G
--
L
---
K
C
K
--
S
----
Q
F
--
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
-
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
----
Q
W
D
RKD-----
I
K
K
-
G
E
--------
K
--
N
---
T
I
---
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
NP
E
T
H
-
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
---
L
-------
K
F
N
-----
P
E
T
D
F
L
-----------
T
G
K
D
G
------
K
K
F
K
L
E
A
P
D
---------------
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
---
4
PsiBlast_PDB
52.42
26%
-63
- C2 -
4KP1
6
LEUC_METJA
A:
[23-439]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
---
T
I
V
E
K
I
L
A
K
A
S
G
K
K
E
------------------------
V
S
P
G
-
D
-
I
V
M
A
N
I
D
V
A
M
V
H
D
I
T
G
P
L
T
V
N
T
L
K
E
Y
G
---
I
-
E
K
V
W
N
P
E
K
I
------
V
I
-
L
F
D
---------
H
------
Q
---
V
P
-
A
D
S
------
I
K
A
----
A
E
N
H
I
------
L
M
--------
R
K
F
V
K
-
E
Q
---
G
I
K
Y
F
Y
D
I
--
R
--
E
G
V
C
H
Q
----
V
-
L
P
E
K
G
-----------
H
V
A
-------
P
G
E
V
V
V
G
A
D
S
----
H
T
CTHGAFG
A
F
A
T
--
G
---
I
------
G
S
T
D
--
M
-----------------
A
H
V
F
A
T
G
K
-
L
---
W
F
-------
K
V
--
P
E
T
I
Y
F
N
I
T
G
D
L
Q
P
Y
V
T
S
K
D
V
I
L
S
I
I
G
E
V
GVDGA
T
Y
K
A
C
Q
-
F
G
--
G
E
T
V
K
K
M
----------------------------
S
I
A
-
S
R
M
T
M
T
N
M
A
I
-
E
M
G
G
K
T
G
I
I
E
-
P
D
E
K
T
I
Q
Y
V
K
E
A
M
--------
K
K
H
G
T
E
R
P
F
E
------------------------
V
I
----
K
G
--
D
E
D
-
A
E
F
A
E
V
--------------
Y
E
I
E
-
A
D
K
----------
I
E
P
V
F
A
C
P
H
N
V
D
N
V
K
Q
A
R
E
V
-----------
A
-------
G
---------------------------------------
K
-
P
I
D
Q
--------
V
----------------------------
F
I
G
S
C
--
T
-----
N
G
R
-
L
E
D
L
R
M
A
I
K
I
I
E
K
------
H
--
G
---
G
I
A
D
D
V
----
R
V
--
V
V
T
P
A
S
R
E
E
Y
L
K
A
L
-
K
E
G
I
I
E
K
F
L
K
Y
G
C
V
V
T
N
P
S
C
S
A
C
M
G
----
S
L
Y
--------
G
-
V
L
G
P
--------
G
--
E
---
V
C
---
V
S
T
S
N
R
N
F
R
G
R
Q
G
S
L-
E
A
E
-
I
-
Y
L
A
S
P
I
T
A
A
A
C
A
V
K
G
E
---
L
-------
V
D
P
-----
R
D
L
---------------------------------------------------------------------------
13
HHSearch
52.26
21%
-55
- C2 -
2B3Y
4
ACOC_HUMAN
A:
[71-568]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
-
I
-
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
-
K
L
G
G
D
P
E
K
I
NPV
C
P
A
D
L
-
V
I
D
---------
H
------
S
---
I
Q
V
D
F
N
------
R
R
A
----
D
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
E
R
F
E
F
L
K
W
G
S
Q
A
F
H
---
N
M
R
I---
I
--
P
P
G
S
G
I
I
H
Q
----
V
-
N
--
L
E
YLARVVFDQDG
Y
Y
Y
-------
P
D
-
S
L
V
G
T
D
S
----
H
T
-------
T
M
I
D
--
G
LGI
L
-
G
W
G
V
-
G
G
I
E
--
A
-----------------
E
A
V
M
L
G
Q
P
-
I
---
S
M
-------
V
L
--
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
-------------
T
K
-
H
L
----------
R
Q
V
G
V
V
-----
G
K
F
V
E
F
--
F
G
P
G
V
A
Q
L
S
I
A
-
D
R
A
T
I
A
N
M
C
P
-
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
-
I
T
Y
L
V
Q
T
----------
G
R
D
E
-----
E
K
----------
L
K
Y
I
K
K
Y
L
Q
A
V
G
M
F
RDFN
D
P
--
S
Q
D
-
P
D
F
T
Q
V
--------------
V
E
L
D
L
K
T
V
-----------
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
-----------
K
-------
K
D
F
E
S
C
L
G
AKQGFKGFQVAPEHHN
D
H
K
T
F
I
Y
DN
T
E
F
T
L
A
H
G
-
S
V
V
I
--------
A
----------------------------
A
I
T
S
C
--
T
-----
N
-
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
-
K
A
V
D
A
G
--
L
---
N
V
M
PY
I
----
K
T
--
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
-
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
----
N
S
G
--------
P
-
L
-
P
E
P
V
V
E
A
I
T
Q
G
--
D
LV
A
V
G
---
V
L
S
G
N
R
N
F
E
G
R
V
H
P
N-
T
R
A
-
N
-
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
---
I
-------
R
I
D
-----
F
E
K
E
P
L
-----------
G
V
N
A
K
------
G
Q
Q
V
F
L
K
D
I
---------------
W
P
T
R
D
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
K
E
V
---
2
PsiBlast_PDB
52.07
27%
-61
- C2 -
4NQY
1
LEUC_METJA
A:
[22-437]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
---
T
I
V
E
K
I
L
A
K
A
S
G
K
K
E
------------------------
V
S
P
G
-
D
-
I
V
M
A
N
I
D
V
A
M
V
H
D
I
T
G
P
L
T
V
N
T
L
K
E
Y
G
---
I
-
E
K
V
W
N
P
E
K
I
------
V
I
-
L
F
D
----------------------------------------
N
H
I
L
------
M
R
--------
K
F
V
K
E
-
Q
G
IK
Y
F
Y
D
----
I
--
R
--
E
G
V
C
H
Q
----
V
-
L
P
E
K
G
-----------
H
V
A
-------
P
G
E
V
V
V
G
A
D
S
----
H
T
CTHGAFG
A
F
A
T
--
G
---
I
------
G
S
T
D
--
M
-----------------
A
H
V
F
A
T
G
K
-
L
---
W
F
-------
K
V
--
P
E
T
I
Y
F
N
I
T
G
D
L
Q
P
Y
V
T
S
K
D
V
I
L
S
I
I
G
E
V
GVDGA
T
Y
K
A
C
Q
-
F
G
--
G
E
T
V
K
K
----------------------------
M
S
I
A
-
S
R
M
T
M
T
N
M
A
I
-
E
M
G
G
K
T
G
I
I
E
-
P
D
E
K
T
I
Q
Y
V
K
E
A
M
--------
K
K
H
G
T
E
R
P
F
------------------------
E
V
I
----
K
G
--
D
E
D
-
A
E
F
A
E
V
--------------
Y
E
I
E
-
A
D
K
----------
I
E
P
V
F
A
C
P
H
N
V
D
N
V
K
Q
A
R
E
V
-----------
A
-------
G
---------------------------------------
K
-
P
I
D
Q
--------
V
----------------------------
F
I
G
S
C
--
T
-----
N
G
R
-
L
E
D
L
R
M
A
I
K
I
I
E
K
------
H
--
G
---
G
I
A
D
D
V
----
R
V
--
V
V
T
P
A
S
R
E
E
Y
L
K
A
L
-
K
E
G
I
I
E
K
F
L
K
Y
G
C
V
V
T
N
P
S
C
S
A
C
M
G
----
S
L
Y
--------
G
-
V
-
L
G
P-------
G
--
E
---
V
C
---
V
S
T
S
N
R
N
F
R
G
R
Q
G
S
L-
E
A
E
-
I
-
Y
L
A
S
P
I
T
A
A
A
C
A
V
K
G
E
---
L
-------
V
D
P
-----
R
D
----------------------------------------------------------------------------
24
Fugue
51.47
20%
-49
- C2 -
1ACO
2
?
?:
[2-528]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
K
V
A
M
S
H
F
E
P
H
E
Y
I
R
Y
D
L
L
E
K
N
I
D
I
V
R
K
R
L
N
R
P
L
---
T
L
S
E
K
I
V
Y
G
H
L
D
D
P
A
N
Q
E
---------------------
I
E
R
G
K
T
-
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
---
L
-
P
K
-
V
A
V
P
S
T
------
I
H
-
C
D
H
L
I
E
A
Q
LGG
E
K
------
D
---
L
R
R
A
K
D
------
I
N
Q
----
E
V
Y
N
F
------
L
A
--------
T
A
G
A
K
-
Y
G
---
V
G
F
----
W
--
R
P
G
S
G
I
I
H
Q
----
I
I
L
--
E
N
-----------
Y
A
Y
-------
P
G
V
L
L
I
G
T
D
S
----
H
T
-------
P
N
G
G
--
G
LG
G
I
-
C
I
G
V
-
G
G
A
D
--
A
-----------------
V
D
V
M
A
G
I
P
-
W
---
E
L
-------
K
C
--
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
---------
A
G
I
L
T
V
-
K
G
--
G
------------
T
-----
G
A
I
V
E
Y
H
G
P
--
G
V
D
S
I
S
C
T
-
G
M
A
T
I
C
N
M
G
A
-
E
I
G
A
T
T
S
V
F
P
-
Y
N
H
R
M
K
K
Y
L
S
K
T
-------------------
G
R
----------
A
D
I
A
N
L
A
D
E
F
K
D
H
L
----
V
P
--
D
S
G
-
C
H
Y
D
Q
L
--------------
I
E
I
N
L
S
E
L
-----------
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
-----------
G
-------
S
---------------------------------------
V
-
A
E
K
E
GWPLDIR
V
G
----------------------------
L
I
G
S
C
--
T
-----
N
-
S
S
Y
E
D
M
G
R
S
A
A
V
A
K
Q
-
A
----
L
--
A
H
GL
K
C
K
--
S
----
Q
F
--
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
-
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
QWDR
K
D
I
--------
K
-
K
-
G
E
--------
K
--
N
---
T
I
---
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
NP
E
T
H
-
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
---
L
KFNPE
T
D
F
L
T
G
KDG
K
K
F
K
L
E
A
-----------
P
D
A
D
E
LPRAEF
D
P
G
Q
D
T
Y
Q
H
---------------
P
P
K
D
S
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
L
L
E
---
5
PsiBlast_PDB
48.38
22%
-63
- C2 -
2B3X
3
ACOC_HUMAN
A:
[171-565]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
S
G
I
I
H
Q
V
N
L
E
Y
-
L
--
A
R
-----------
V
V
F
DQDG
Y
Y
Y
P
D
S
L
-
V
G
T
D
S
----
H
T
-------
T
M
I
D
--
G
---
L
-
G
I
L
G
W
G
V
G
G
--
I
-----------------
E
A
E
A
V
M
L
G
-
Q
---
P
I
-------
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
---------
T
K
H
L
R
Q
-
V
G
--
V
V
-----
G
K
F
V
E
F
F
-----
G
-------
P
--
G
V
A
Q
L
S
I
A
-
D
R
A
T
I
A
N
M
C
P
-
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
I
T
-----------
Y
L
V
Q
T
G
R
-
D
E
E
K
L
K
Y
I
----------
K
K
Y
L
Q
A
V
G
M
F
R
D
F
N
----
D
P
--
S
Q
D
-
P
D
F
T
Q
V
--------------
V
E
L
D
L
K
T
V
----------
V
-
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
AK
Q
-------
G
---------------------------------------
F
-
K
G
F
Q
--------
V
APEHHN
D
H
K
T
F
I
Y
DN
T
E
F
T
L
A
HGSVVIA
A
I
T
S
C
TN
T
-----
S
-
N
-
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
----
D
--
A
---
G
L
N
--
V
MPYI
K
T
--
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
-
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
----
N
S
G
PLP
E
P
V
V
E
A
-
I
-
T
Q
--------
G
--
D
---
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
V
H
P
--
N
T
R
-
A
N
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
---
I
-------
R
I
D
-----
F
E
K
E
P
L
-----------
G
V
N
A
K
------
G
Q
Q
V
F
L
K
D
I
---------------
W
P
T
R
D
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
K
E
V
---
6
PsiBlast_PDB
48.26
22%
-64
- C2 -
2B3Y
3
ACOC_HUMAN
A:
[171-565]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
S
G
I
I
H
Q
V
N
L
E
Y
-
L
--
A
R
-----------
V
V
F
DQDG
Y
Y
Y
P
D
S
L
-
V
G
T
D
S
----
H
T
-------
T
M
I
D
--
G
---
L
-
G
I
L
G
W
G
V
G
G
--
I
-----------------
E
A
E
A
V
M
L
G
-
Q
---
P
I
-------
S
M
VL
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
---------
T
K
H
L
R
Q
-
V
G
--
V
V
-----
G
K
F
V
E
F
F
-----
G
-------
P
--
G
V
A
Q
L
S
I
A
-
D
R
A
T
I
A
N
M
C
P
-
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
I
T
-----------
Y
L
V
Q
T
G
R
-
D
E
E
K
L
K
Y
I
----------
K
K
Y
L
Q
A
V
G
M
F
R
D
F
N
----
D
P
--
S
Q
D
-
P
D
F
T
Q
V
--------------
V
E
L
D
L
K
T
V
----------
V
-
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
AK
Q
-------
G
---------------------------------------
F
-
K
G
F
Q
--------
V
APEHHN
D
H
K
T
F
I
Y
DN
T
E
F
T
L
A
HGSVVIA
A
I
T
S
C
TN
T
-----
S
-
N
-
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
----
D
--
A
---
G
L
N
--
V
MPYI
K
T
--
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
-
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
----
N
S
G
PLP
E
P
V
V
E
A
-
I
-
T
Q
--------
G
--
D
---
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
V
H
P
--
N
T
R
-
A
N
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
---
I
-------
R
I
D
-----
F
E
K
E
P
L
-----------
G
V
N
A
K
------
G
Q
Q
V
F
L
K
D
I
---------------
W
P
T
R
D
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
K
E
V
---
27
Fugue
41.64
15%
-23
- C1 -
4KVM
11
NAT1_SCHPO
A:
[5-731]
-
Q
L
S
P
K
E
I
T
L
F
R
T
A
L
K
C
Y
E
T
K
Q
Y
K
K
G
L
K
A
I
E
P
L
--
L
E
R
H
P
E
H
G
E
S
L
A
I
K
G
I
--
L
L
H
S
L
G
N
T
K
E
G
-
Y
D
N
V
R
L
G
L
R
N
D
V
G
----------
S
G
V
C
W
H
I
F
G
L
I
S
R
A
D
K
D
Y
V
Q
A
A
--------
K
C
Y
I
N
A
H
K
L
----
E
K
N
N
S
S
L
L
R
D
L
A
L
L
Q
S
Q
--
L
R
Q
Y
K
A
L
A
D
T
R
N
A
L
L
Q
D
N
P
G
V
R
A
N
W
S
A
L
A
V
A
----
Q
F
L
R
G
E
-------
Y
A
S
A
-
Y
K
I
V
-------
D
A
F
E
S
T
I
N
Q
G
V
P
V
D
T
Q
E
-
E
S
E
A
----
M
L
F
M
N
L
V
---------
I
L
K
--
K
D
G
----
V
E
D
A
Y
K
H
L
L
S
I
E
K
K
V
L
D
R
V
A
F
--
L
E
T
R
A
E
Y
E
L
Y
L
S
K
M
E
E
A
K
S
T
I
Y
L
-------------------
L
L
D
R
N
----
P
D
N
---
H
-------------
Q
Y
Y
Y
N
L
Q
R
A
Y
G
Y
-
E
D
A
S
--
G
---
K
---------
V
L
--
D
S
A
E
W
L
N
L
Y
S
Q
L
A
K
-------
R
Y
P
K
S
E
C
----
P
T
R
L
P
L
E
K
L
-------
E
G
----
D
E
F
L
T
H
V
D
L
Y
L
R
K
K
L
K
R
----
G
I
P
S
V
F
V
D
V
K
S
L
Y
K
D
T
K
K
C
---
K
V
V
E
D
L
V
S
K
Y
A
--------------------------------------
S
S
L
S
T
T
N
K
F
S
E
D
D
D
N
S
Q
I
E
I
P
T
-----
T
-
L
L
-
W
T
Y
Y
F
L
------
A
Q
-
H
F
D
---------
H
------
V
GE
L
E
K
A
E
K
Y
------
V
D
L
----
A
I
D
H
T
------
P
T
----------------------------------
L
V
E
L
----
F
-
M
--
T
K
-----------
A
R
I
-------
S
K
H
K
G
E
L
Q
T
A
----
M
E
-------
I
M
D
H
--
A
---
R
-
K
L
D
L
-
Q
D
R
F
--
I
-----------------
N
G
K
C
A
K
Y
M
-
L
R
N
D
E
N
-------
E
L
--
A
A
K
T
V
S
L
F
T
R
N
E
A
V
G
G
A
V
G
D
L
A
D
M
Q
---------
C
L
W
Y
M
L
-
E
D
--
G
K
S
F
A
R
Q
K
K
F
A
L
A
L
-----
K
R
F
S
T
V
--
F
--
K
I
F
D
T
W
A
D
-
D
Q
F
D
F
H
F
F
A
F
-
R
K
G
S
---------------
L
R
T
Y
L
D
L
M
S
W
E
-
D
S
V
Y
D
D
P
S
F
R
E
A
A
----------
Q
G
S
I
E
I
Y
F
A
L
F
D
L
P
----
F
A
--
K
Y
S
----------------------------------------------
P
K
L
P
D
F
E
K
L
S
S
G
E
-----------
I
-------------------------------------------------------------------------------------------------------------
N
E
E
E
E
K
K
I
Y
K
K
-
L
----
K
--
K
---
D
L
S
--
K
----
R
L
--
E
R
A
E
K
L
K
E
A
D
K
S
R
K
Y
D
E
D
P
L
G
------------------------
E
N
--------
L
-
V
-
A
T
-----------
S
---
E
P
---
L
K
E
A
Q
K
C
L
E
K
L
L
P
Y
--
G
D
K
-
N
-
P
S
A
Y
I
L
A
A
Q
L
Y
T
R
L
K
N
---
F
-------
D
T
A
-----
S
K
Y
L
E
Q
-----------
A
K
V
I
L
------
G
-----------------------
Q
N
D
P
T
V
I
S
T
E
K
F
Y
N
S
I
K
T
Q
S
N
A
A
---
25
Fugue
39.00
18%
-29
- C1 -
4M5D
14
UTP22_YEAST
A:
[81-1237]
T
A
T
E
S
Y
D
I
H
I
A
R
E
T
A
E
L
F
K
S
N
I
F
K
L
Q
I
D
E
L
L
E
Q
V
K
L
K
Q
K
H
V
L
K
V
E
K
F
L
H
K
L
Y
D
I
L
Q
E
I
P
D
W
E
E
K
S
L
A
E
V
D
S
F
F
K
N
K
I
V
SVPFVDPKPI
P
Q
N
T
N
Y
K
F
N
Y
K
K
P
D
I
S
L
I
G
S
F
A
LKAGIYQP
N
G
S
S
I
D
T
L
L
T
M
P
K
E
L
F
E
K
K
D
F
L
N
F
R
C
L
H
K
R
S
V
Y
L
A
Y
L
T
H
H
L
L
I
L
L
K
K
D
K
L
D
S
F
L
Q
L
E
Y
S
Y
F
D
N
DPL
L
P
I
L
R
I
S
C
S
K
D
Y
N
F
Y
K
T
R
-
F
S
I
N
L
L
I
G
F
P
Y
K
V
F
E
P
K
K
L
L
P
N
R
N
C
I
R
I
L
P
A
T
P
----
L
Y
N
F
S
V
L
S
S
S
T
H
E
N
Y
L
K
Y
L
--
Y
K
T
K
K
Q
T
E
S
F
V
E
A
T
V
L
G
R
L
W
-
L
Q
Q
R
G
F
S
SN
M
S
H
S
G
S
L
G
G
F
G
T
F
E
F
T
I
L
M
A
A
L
L
N
GGGINSNKILLHGFS
S
Y
Q
L
F
K
G
V
I
K
Y
L
A
T
M
DLC
H
D
G
-
H
L
Q
F
H
S
N
P
A
S
K
Y
I
D
---
E
G
F
Q
T
P
T
L
F
D
--
K
---
S
TKVNILTKM
T
V
--
S
S
Y
Q
I
L
K
E
Y
A
G
E
T
L
R
M
L
N
NVV
Q
D
Q
F
S
N
I
FLTN
I
S
R
F
D
N
L
K
Y
D
L
C
Y
D
V
Q
L
P
LGKY
N
N
L
E
T
S
L
A
A
T
F
G
S
M
E
R
V
K
F
I
T
L
E
N
F
L
A
H
K
I
T
N
V
A
R
Y
A
L
G
D
RIK
Y
I
Q
I
E
M
V
G
Q
K
S
D
F
P
I
T
K
R
KVYSNTGGNHFNFD
F
V
R
V
K
L
I
V
N
P
S
-
E
--
C
D
K
L
V
T
K
G
P
A
H
S
E
T
M
S
T
E
A
A
V
F
K
N
F
W
---
G
-
I
K
-
S
S
L
R
R
F
------
K
D
G
S
I
T
---------
H
------
C
---
C
V
W
S
T
S
------
S
S
E
----
P
I
I
S
S
------
I
V
--------
N
F
A
L
Q
-
K
H
----
V
S
----
K
K
A
Q
I
S
N
E
T
I
K
K
----
F
-
H
--
N
F
-----------
L
P
L
-------
P
N
L
P
S
S
A
K
T
S
VLNL
S
S
-------
F
F
N
L
--
K
---
K
-
S
F
D
D
-
L
Y
K
I
--
I
F
Q
MKLPLSVK
S
I
L
P
V
G
S
A
F
R
Y
T
S
L
C
-
Q
---
P
V
PFAYSDP
D
F
--
F
Q
D
V
I
L
E
F
E
T
S
P
K
W
P
D
E
I
T
S
L
E
K
A
K
---------
T
A
F
L
L
K
I
Q
E
--
E
L
S
A
N
S
S
T
Y
R
S
F
F
S
R
D
ESI
P
Y
N
L
E
I
--
V
--
T
L
N
I
L
T
P
E
G
Y
G
F
K
F
R
V
L
T
E
R
D
E
I
L
Y
L
R
A
I
A
N
A
R
N
E
L
K
P
E
L
E
A
T
F
L
K
F
T
A
K
Y
L
A
S
V
R
H
T
R
T
L
E
N
I
SHSYQF
Y
S
P
V
V
R
L
F
K
R
W
L
D
T
H
L
L
L
----
G
H
IT
D
E
L
-
A
E
L
I
A
I
K
PFVDPAPYFIPGS
L
E
N
G
F
L
K
V
L
K
F
I
S
Q
WNWK
D
D
P
L
I
L
D
L
V
K
P
E
E
R
--
L
T
L
A
-----------
Q
-------
Y
---------------------------------------
K
-
G
I
Q
M
--------
N
----------------------------
F
T
N
L
R
--
N
SDPNG
T
-
H
-
L
Q
F
F
V
A
S
K
N
D
P
S
G
-
I
----
L
YS
S
---
G
I
P
--
L
----
P
I
A
T
R
L
T
A
L
A
K
V
A
V
N
L
L
Q
-
T
H
G
L
N
Q
Q
T
I
N
L
L
F
T
P
G
L
K
D
Y
D
F
V
V
D
----
L
R
T
--------
P
-
I
-
G
L
--------
K
--
S
---
S
C
G--
I
L
S
A
P
S
N
F
P
E
N
L
N
D
--
L
S
E
-
K
-
M
D
P
T
Y
Q
L
V
K
Y
L
N
L
K
Y
K
N
S
L
I
-------
L
S
S
-----
R
K
Y
I
G
V
NGGEKGD
K
N
V
I
T
G
L
I
K
------
P
L
F
K
G
A
H
K
F
RVNLDCNVKPVDDEN
V
I
L
N
K
E
A
I
F
H
E
I
A
A
F
G
N
D
M
V
I
N
F
E
T
D
17
HHSearch
37.07
28%
-53
- C2 -
1V7L
-
LEUD_PYRHO
A:
[2-158]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
T
G
K
V
-
W
K
F
G
-------
D
D
I
S
T
D
E
I
T
P
G
R
Y
N
L
-
T
-
K
D
P
K
----
E
L
A
K
I
A
F
---------
I
E
V
--
R
P
D
F
----------
A
R
---
N
-
V
--
R
P
G
D
--
V
V
V
A
G
K
N
F
G
I
G
S
S
R
E
S
A
A
L
A
L
--------------------------------
K
---
A
L
G
I
A
G
V
I
A
E
S
F
G
R
I
F
Y
R
N
A
I
N
I
G
I
P
L
L
L
G
K
--
T
---
E
---------
G
L
--
K
D
G
D
L
V
T
V
N
W
E
T
G
E
V
R
-----
K
--
G
D
E
I
----
L
-
M
F
E
P
L
E
D
F
L
L
E
I
V
R
E
G
----
G
I
L
E
Y
I
R
R
R
G
D
L
C
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
36.98
17%
-35
- C2 -
3H5J
4
LEUD_MYCTU
A:
[7-168]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
T
H
S
G
I
G
V
P
L
R
R
-------
S
N
V
D
T
D
Q
I
I
P
A
V
F
L
K
-
R
-
V
T
R
T
----
G
F
E
D
G
L
F
---------
A
G
W
RS
D
P
A
F
----------
V
L
N
L
S
P
-
F
--
D
R
G
S
--
V
L
V
A
G
P
D
F
G
T
G
S
S
R
E
H
A
V
W
A
L
--------------------------------
M
---
D
Y
G
F
R
V
V
I
S
S
R
F
G
D
I
F
R
G
N
A
G
K
A
G
L
L
A
A
E
V
A
--
Q
D
D
V
E
L
L
W
K
-----
L
I
E
Q
S
P
G
L
E
I
T
A
N
L
Q
D
R
I
I
T
-----
A
--
A
T
V
V
----
L
P
-
F
K
I
D
D
-
H
S
A
W
R
L
L
E
G
----
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
36.62
22%
-61
- C2 -
2PKP
2
HACB_METJA
A:
[2-163]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
K
G
R
A
-
H
K
F
G
-------
D
D
V
D
T
D
A
I
I
P
G
P
Y
L
R
T
--
T
D
P
Y
----
E
L
A
S
H
C
M
---------
A
G
I
--
D
E
N
F
----------
P
K
---
K
-
V
--
K
E
G
D
--
V
I
V
A
G
E
N
F
G
C
G
S
S
R
E
Q
A
V
I
A
I
--------------------------------
K
---
Y
C
G
I
K
A
V
I
A
K
S
F
A
R
I
F
Y
R
N
A
I
N
V
G
L
I
P
I
I
A
N
--
T
---
D
---------
E
I
--
K
D
G
D
I
V
E
I
D
L
D
K
E
E
I
V
-----
I
T
N
K
N
K
T
----
I
K
-
C
E
T
P
K
G
L
E
R
E
I
L
A
A
G
----
G
L
V
N
Y
L
K
K
R
K
L
I
Q
S
K
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
36.44
24%
-46
- C2 -
3VBA
-
LEUD_METJA
A:
[2-164]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
I
I
K
G
R
V
-
W
K
F
G
-------
N
N
V
D
T
D
A
I
L
P
A
R
Y
L
V
-
Y
-
T
K
P
E
----
E
L
A
Q
F
V
M
---------
T
G
A
--
D
P
D
F
----------
P
K
---
K
-
V
--
K
P
G
D
--
I
I
V
G
G
K
N
F
G
C
G
S
S
R
E
H
A
P
L
G
L
--------------------------------
K
---
G
A
G
I
S
C
V
I
A
E
S
F
A
R
I
F
Y
R
N
A
I
N
V
G
L
P
L
I
E
C
K
G
I
S
---
E
---------
K
V
--
N
E
G
D
E
L
E
V
N
L
E
T
G
E
I
K
-----
N
L
T
T
G
E
V
----
L
K
-
G
Q
K
L
P
E
F
M
M
E
I
L
E
A
G
----
G
L
M
P
Y
L
K
K
K
M
A
E
S
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
36.20
22%
-43
- C2 -
3SN2
-
ACOC_RABIT
A:
[172-386]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
S
G
I
I
H
Q
V
N
L
E
Y
-
L
--
A
R
-----------
V
V
F
DQDG
Y
Y
Y
P
D
S
L
-
V
G
T
D
S
----
H
T
-------
T
M
I
D
--
G
---
L
-
G
V
L
G
-
W
G
V
G
--
G
-----------------
I
E
A
E
A
V
M
L
G
Q
---
P
I
-------
S
M
VL
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
---------
T
K
H
L
R
Q
-
V
G
--
V
V
-----
G
K
F
V
E
F
F
-----
G
-------
P
--
G
V
A
Q
L
S
I
A
-
D
R
A
T
I
A
N
M
C
P
-
E
Y
G
A
T
A
T
F
F
P
V
D
E
V
S
I
-----------
K
Y
L
V
Q
T
G
R
D
E
S
K
V
K
Q
I
R
----------
K
Y
L
Q
A
V
G
M
F
R
-
D
Y
S
----
D
P
--
S
Q
D
-
P
D
F
T
Q
V
--------------
V
E
L
D
L
K
T
V
----------
V
-
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
-----------
K
-------
K
---------------------------------------
D
-
F
E
S
C
--------
L
----------------------------
G
A
K
Q
G
--
F
-----
K
-
G
-
F
Q
V
A
P
D
H
H
N
D
H
K
T
-
F
----
I
--
Y
---
N
D
S
--
E
----
F
T
--
L
S
H
G
S
V
V
I
A
A
I
T
S
S
-
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
L
N
----
V
K
P
--------
Y
-
V
-
K
T
--------
S
--
L
---
S
P
---
G
S
G
V
V
T
Y
Y
L
R
E
S
G
V
--
M
P
Y
-
L
-
S
Q
L
G
F
D
V
V
P
L
P
E
P
V
V
E
---
A
-------
I
T
Q
-----
G
D
L
V
A
V
-----------
G
V
L
S
G
------
N
R
N
F
E
G
R
V
H
---------------
P
N
T
R
A
N
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
---