@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA1807: (2016-02-01 )
MSENILEIRDLAVEFLSGEQRQRVVEGVSFDIRQGETLALVGESGSGKSVTAHSILRLLPYSVASHPAGSIHYQGEDLLKLPERRLRGIRGNRIAMVFQEPMTSLNPLHTIEKQLAEVLALHKGLGGAKASARILELLELVGIPEPAKRLKAYPHELSGGQRQRVMIAMALACEPQLLIADEPTTALDVTVQLKILDLLKDLQARLGMSLLLITHDLNLVRRIAHRVCVMQQGRIVEQASCQELFAAPRHPYTRELLNAEPSGAPASNPPGETLLAVDDLRVWFPIRKGVFRRTVDHVKAVDGVNFELPRGQTLGIVGESGSGKSTLGLAILRLLESQGGIRFEGTRLDGLAQHDVRPLRREMQVVFQDPYGSLSPRMCVGEIVGEGLRIHRIGSEAEQEQAIIDALVEVGLDPQTRYRYPHEFSGGQRQRIAIARALVLKPALILLDEPTSALDRTVQRQVVELLRQLQGKYNLTYLFISHDLAVVKALSHQLMVVRHGKVVEQGSAEAVFASPQHPYTQQLLEAAFMAPASAEN
Atome Classification :
(27 SA)
.........10........20........30........40........50........60.......-.70.....-----------..---------.80...-.....90.-.......--100.......110.....--..120.......130...-----....140.....--..150.......160.......170--.......180.......190.......200.......210.......220.......230-.......240.......250........-----260..---------------.....270.......280.......290.......300.......310.......320.......330.....-..340.......350----.........360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSE
N
I
L
E
I
R
D
L
A
V
E
F
LS
G
E
Q
R
Q
R
V
V
EGV
S
F
D
IRQG
E
T
L
A
L
V
GESGSGKS
V
T
A
H
S
I
L
R
L
L
P
Y
S
VASHPA-
G
S
I
H
YQG
E
-----------
D
L
---------
L
K
L
P
E
R
-
R
L
RGIRG
N
-
R
I
A
M
V
FQ--EPMTSLN
P
L
H
T
I
E
K
Q
L
A
E
--
V
L
A
L
H
KGLGG
A
K
A
S
A
R
I
L
-----
E
L
L
E
L
VGIP
E
P
A
--
K
R
L
K
AYPHELSGGQ
R
Q
R
V
M
I
A
M
A
LA--CE
P
Q
L
L
I
ADEPT
T
A
L
D
V
T
V
Q
L
K
I
L
D
L
L
K
D
L
Q
A
RLG
M
S
L
L
L
I
TH
D
L
N
L
V
R
R
I
A
H
R
V
C
V
M
QQ-G
R
I
V
E
Q
A
S
C
Q
E
L
FAAPRH-
P
Y
T
R
E
L
LNA-----EPSGA---------------PASNPPG
E
T
L
L
A
V
DD
L
R
V
W
F
P
I
R
K
G
V
F
R
R
T
V
D
H
V
KAVDGV
N
F
ELPRG
Q
T
L
G
I
VGESGSGK
S
T
L
G
L
A
I
L
R
L
L
E
S-QG
G
I
R
F
EGTRLD
G
------
L
A
QH
D
V
R
P
L
R
R
E
M
Q
V
V
F
QDPYGSLS
P
R
M
C
V
G
E
I
V
GEG
L
R
I
H
RIG
S
E
A
E
Q
E
Q
A
I
I
D
A
L
V
EVGLDPQTRYRYPHEFSGGQ
R
Q
R
I
A
I
A
R
A
L
VLK
P
A
L
I
L
LDE
P
T
S
A
L
D
R
T
V
Q
R
Q
V
V
E
L
L
R
Q
L
QGKY
N
L
T
Y
L
F
ISH
D
L
A
V
V
K
A
L
S
H
Q
L
M
V
V
RHG
K
V
VEQGSA
E
A
V
FASPQH
P
Y
T
Q
Q
L
L
E
A
A
FMAPASAEN
28
PsiBlast_CBE
79.09
37%
-116
- C3 -
4U02
1
?
C:
[2-239]
--
E
P
I
I
R
I
R
N
L
H
K
W
F
G
P
----
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
-----
E
-
G
E
V
V
V
D
G
-------------
L
---------
S
V
K
D
D
R
-
A
L
R
E
I
R
-
R
-
E
V
G
M
V
F
Q
--
Q
--
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
--
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
-----
E
L
L
E
R
V
G
I
L
D
Q
A
--
R
K
---
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
--
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
-
E
R
T
R
S
F
L
Q
R
-----
V
L
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
78.20
37%
-114
- C3 -
4U00
3
?
A:
[3-239]
---
P
I
I
R
I
R
N
L
H
K
W
F
G
P
----
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
-----
E
-
G
E
V
V
V
D
G
-------------
L
---------
S
V
K
D
D
R
-
A
L
R
E
I
R
-
R
-
E
V
G
M
V
F
Q
--
Q
--
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
--
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
-----
E
L
L
E
R
V
G
I
L
D
Q
A
--
R
K
---
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
--
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
-
E
R
T
R
S
F
L
Q
R
-----
V
L
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
76.59
37%
-110
- C3 -
4U02
1
?
D:
[2-239]
--
E
P
I
I
R
I
R
N
L
H
K
W
F
G
P
----
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
-----
E
-
G
E
V
V
V
D
G
-------------
L
---------
S
V
K
D
D
R
-
A
L
R
E
I
R
-
R
-
E
V
G
M
V
F
Q
--
Q
--
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
--
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
-----
E
L
L
E
R
V
G
I
L
D
Q
A
--
R
K
---
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
--
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
-
E
R
T
R
S
F
L
Q
R
-----
V
L
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
76.57
37%
-107
- C3 -
4U02
1
?
A:
[2-239]
--
E
P
I
I
R
I
R
N
L
H
K
W
F
G
P
----
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
-----
E
-
G
E
V
V
V
D
G
-------------
L
---------
S
V
K
D
D
R
-
A
L
R
E
I
R
-
R
-
E
V
G
M
V
F
Q
--
Q
--
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
--
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
-----
E
L
L
E
R
V
G
I
L
D
Q
A
--
R
K
---
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
--
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
-
E
R
T
R
S
F
L
Q
R
-----
V
L
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
75.80
37%
-108
- C3 -
4U02
1
?
B:
[2-239]
--
E
P
I
I
R
I
R
N
L
H
K
W
F
G
P
----
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
-----
E
-
G
E
V
V
V
D
G
-------------
L
---------
S
V
K
D
D
R
-
A
L
R
E
I
R
-
R
-
E
V
G
M
V
F
Q
--
Q
--
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
--
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
-----
E
L
L
E
R
V
G
I
L
D
Q
A
--
R
K
---
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
--
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
-
E
R
T
R
S
F
L
Q
R
-----
V
L
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
Fugue
74.57
29%
-115
- C3 -
3TUZ
3
METN_ECOLI
H:
[23-362]
---
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
------
G
S
V
L
V
D
G
Q
-----------
E
L
---------
T
T
L
S
E
S
-
E
L
T
K
A
R
R
Q
--
I
G
M
I
F
Q
--
H
F
--
N
L
L
S
S
R
T
V
F
G
N
V
A
L
--
P
L
E
L
D
-
N
T
P
K
D
E
V
K
R
R
V
T
-----
E
L
L
S
L
V
G
L
G
D
K
H
--
D
S
---
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
--
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
-
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
-
P
L
A
Q
K
F
I
Q
S
TLHLD
I
P
E
D
Y
---------------
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
-
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
------
G
G
V
K
F
G
I
M
L
T
E
M
H
----
G
T
Q
Q
D
T
Q
A
A
I
A
W
------
L
Q
E
H
H
V
K
V
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
71.51
38%
-128
- C3 -
4FWI
3
?
B:
[4-257]
----
I
I
R
V
E
D
L
R
A
V
Y
L
V
R
E
G
T
I
K
A
A
D
G
I
S
L
D
I
L
E
N
S
V
T
A
I
V
G
E
S
A
S
G
K
S
T
I
I
E
A
M
T
K
T
L
P
P
N
-
G
R
I
L
S
-
G
R
V
L
Y
K
G
K
-----------
D
L
---------
L
T
M
R
E
E
-
E
L
R
K
I
R
W
K
-
E
I
A
L
V
P
Q
--
A
A
Q
Q
S
L
N
P
T
M
K
V
I
E
H
F
K
D
--
T
V
E
A
H
----
G
V
R
W
S
H
S
E
L
IEKAS
E
K
L
R
M
V
R
L
-
N
P
E
--
A
V
L
N
S
Y
P
L
Q
L
S
G
G
M
K
Q
R
V
L
I
A
L
A
L
L
--
L
D
P
V
V
L
I
L
D
E
P
T
S
A
L
D
V
L
T
Q
A
H
I
I
Q
L
L
K
E
L
K
K
M
L
K
I
T
L
I
F
V
T
H
D
I
A
V
A
A
E
L
A
D
K
V
A
V
I
Y
G
-
G
N
L
V
E
Y
N
S
T
F
Q
I
F
K
N
P
L
H
-
P
Y
T
R
G
L
I
N
S
-----
I
M
P
I
P
---------------
G
D
P
P
S
L
L
N
P
P
S
G
C
R
F
H
P
R
C
E
Y
A
M
E
I
C
K
K
E
K
P
K
W
I
R
L
D
G
E
A
H
V
A
C
H
L
Y
E
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
70.84
36%
-125
- C3 -
2OUK
1
?
A:
[39-260]
-----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
----
T
F
L
R
C
L
N
L
-
L
E
D
F
D
E
-
G
E
I
I
I
D
G
I
-----------
N
L
----------
K
A
K
D
T
-
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
--
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
--
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
-----
E
L
L
D
K
V
G
L
K
D
K
A
--
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
--
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
K
-----
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
69.73
33%
-119
- C3 -
1B0U
4
HISP_SALTY
A:
[5-255]
---
N
K
L
H
V
I
D
L
H
K
R
Y
G
G
H
E
----
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
----
T
F
L
R
C
I
N
F
-
L
E
K
P
S
E
-
G
A
I
I
V
N
G
Q
-----------
N
I
N
L
V
R
D
KDGQ
L
K
V
A
D
K
N
Q
L
R
L
L
R
-
T
-
R
L
T
M
V
F
Q
HF
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
I
Q
--
V
L
----
G
L
S
K
H
D
A
R
E
R
A
L
-----
K
Y
L
A
K
V
G
I
D
E
R
A
--
Q
--
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
--
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
-
A
E
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
-
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
-
P
R
L
Q
Q
F
L
K
G
-----
S
L
K
K
L
---------------
E
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
68.53
36%
-118
- C3 -
2OLK
2
?
B:
[39-260]
-----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
----
T
F
L
R
C
L
N
L
-
L
E
D
F
D
E
-
G
E
I
I
I
D
G
I
-----------
N
L
----------
K
A
K
D
T
-
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
--
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
--
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
-----
E
L
L
D
K
V
G
L
K
D
K
A
--
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
--
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
K
-----
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
68.33
36%
-120
- C3 -
2OLK
1
?
C:
[39-260]
-----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
----
T
F
L
R
C
L
N
L
-
L
E
D
F
D
E
-
G
E
I
I
I
D
G
I
-----------
N
L
----------
K
A
K
D
T
-
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
--
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
--
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
-----
E
L
L
D
K
V
G
L
K
D
K
A
--
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
--
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
K
-----
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
68.01
36%
-119
- C3 -
2OLK
1
?
A:
[39-260]
-----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
----
T
F
L
R
C
L
N
L
-
L
E
D
F
D
E
-
G
E
I
I
I
D
G
I
-----------
N
L
----------
K
A
K
D
T
-
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
--
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
--
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
-----
E
L
L
D
K
V
G
L
K
D
K
A
--
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
--
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
K
-----
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
67.97
36%
-116
- C3 -
2OUK
2
?
B:
[39-260]
-----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
----
T
F
L
R
C
L
N
L
-
L
E
D
F
D
E
-
G
E
I
I
I
D
G
I
-----------
N
L
----------
K
A
K
D
T
-
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
--
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
--
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
-----
E
L
L
D
K
V
G
L
K
D
K
A
--
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
--
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
K
-----
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
67.76
36%
-117
- C3 -
3C41
3
?
K:
[18-239]
-----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
----
T
F
L
R
C
L
N
L
-
L
E
D
F
D
E
-
G
E
I
I
I
D
G
I
-----------
N
L
----------
K
A
K
D
T
-
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
--
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
--
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
-----
E
L
L
D
K
V
G
L
K
D
K
A
--
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
--
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
K
-----
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
67.72
36%
-122
- C3 -
3C4J
4
?
B:
[39-260]
-----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
----
T
F
L
R
C
L
N
L
-
L
E
D
F
D
E
-
G
E
I
I
I
D
G
I
-----------
N
L
----------
K
A
K
D
T
-
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
--
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
--
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
-----
E
L
L
D
K
V
G
L
K
D
K
A
--
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
--
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
K
-----
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
Fugue
67.06
34%
-111
- C3 -
1B0U
4
HISP_SALTY
A:
[5-261]
---
N
K
L
H
V
I
D
L
H
K
R
Y
G
G
---
H
E
V
L
K
-
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
------
E
G
A
I
I
V
N
G
-QNI
N
L
V
R
D
KDG
Q
L
---------
K
V
A
D
K
N
-
Q
L
R
L
L
R
T
-
R
-
L
T
M
V
F
Q
HF
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
I
Q
VL------
G
L
S
K
H
D
A
R
E
R
A
L
-----
K
Y
L
A
K
V
G
I
D
E
R
A
QG----
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E--
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
-
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
-Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
-
Q
S
P
R
L
Q
Q
F
L
K
G
-----
S
L
K
K
L
---------------
E
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
67.04
36%
-114
- C3 -
2OUK
2
?
D:
[39-260]
-----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
----
T
F
L
R
C
L
N
L
-
L
E
D
F
D
E
-
G
E
I
I
I
D
G
I
-----------
N
L
----------
K
A
K
D
T
-
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
--
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
--
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
-----
E
L
L
D
K
V
G
L
K
D
K
A
--
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
--
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
K
-----
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
Fugue
66.72
24%
-92
- C3 -
1OXS
23
?
C:
[1-352]
--
M
V
R
I
I
V
K
N
V
S
K
V
F
K
K
G
K
--
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
------
G
E
L
Y
F
D
D
R
-----------
L
V
---------
A
S
N
G
K
L
-
I
V
P
P
E
D
R
K
--
I
G
M
V
F
Q
--
T
W
--
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
--
P
L
T
N
-
M
K
M
S
K
E
E
I
R
K
R
V
E
-----
E
V
A
K
I
L
D
I
---
H
--
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
--
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
-
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
-
I
Q
V
A
S
L
I
G
--------------------------------
E
I
N
E
L
E
G
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
I
R
---
P
E
D
V
K
L
S
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
-
Q
G
G
L
F
R
I
T
I
T
P
L
D
SEEEIF
T
Y
S
D
H
P
I
H
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
135
HHSearch
66.67
31%
-107
- C3 -
3TUI
1
METN_ECOLI
C:
[23-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
-------
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
------
L
S
E
S
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
H
F
N
--
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
T
-
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
-
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
125
HHSearch
66.61
25%
-109
- C3 -
1OXX
25
?
K:
[1-310]
--
M
V
R
I
I
V
K
N
V
S
K
V
F
K
K
--
G
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
-----
S
T
-
G
E
L
Y
F
D
D
R
-----------
L
V
---------
A
S
N
G
K
L
-
I
V
-
P
P
E
D
R
-
K
I
G
M
V
F
Q
--
T
W
A
--
L
Y
P
N
L
T
A
F
E
N
I
A
F
--
P
L
T
N
M
K
-
M
S
K
E
E
I
R
K
R
V
E
-----
E
V
A
K
I
L
D
I
H
-----
H
V
L
N
H
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
--
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
-
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
-
I
Q
V
A
S
L
I
G
E
-----
I
N
E
L
E
GKVTNEGVVIGSLRF
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
------------
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
E
E
I
-
F
T
Y
S
D
H
P
I
H
S
G
E
E
------
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
66.58
36%
-119
- C3 -
2OLK
1
?
D:
[39-260]
-----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
----
T
F
L
R
C
L
N
L
-
L
E
D
F
D
E
-
G
E
I
I
I
D
G
I
-----------
N
L
----------
K
A
K
D
T
-
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
--
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
--
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
-----
E
L
L
D
K
V
G
L
K
D
K
A
--
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
--
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
K
-----
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
66.15
36%
-116
- C3 -
2Q0H
4
?
A:
[39-260]
-----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
----
T
F
L
R
C
L
N
L
-
L
E
D
F
D
E
-
G
E
I
I
I
D
G
I
-----------
N
L
----------
K
A
K
D
T
-
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
--
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
--
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
-----
E
L
L
D
K
V
G
L
K
D
K
A
--
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
--
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
K
-----
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
66.15
36%
-119
- C3 -
2OLJ
4
?
A:
[39-260]
-----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
----
T
F
L
R
C
L
N
L
-
L
E
D
F
D
E
-
G
E
I
I
I
D
G
I
-----------
N
L
----------
K
A
K
D
T
-
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
--
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
--
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
-----
E
L
L
D
K
V
G
L
K
D
K
A
--
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
--
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
K
-----
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
66.07
36%
-116
- C3 -
3C4J
3
?
A:
[39-260]
-----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
----
T
F
L
R
C
L
N
L
-
L
E
D
F
D
E
-
G
E
I
I
I
D
G
I
-----------
N
L
----------
K
A
K
D
T
-
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
--
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
--
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
-----
E
L
L
D
K
V
G
L
K
D
K
A
--
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
--
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
K
-----
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
65.65
36%
-118
- C3 -
2Q0H
4
?
B:
[39-260]
-----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
----
T
F
L
R
C
L
N
L
-
L
E
D
F
D
E
-
G
E
I
I
I
D
G
I
-----------
N
L
----------
K
A
K
D
T
-
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
--
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
--
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
-----
E
L
L
D
K
V
G
L
K
D
K
A
--
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
--
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
K
-----
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
65.55
36%
-111
- C3 -
3C41
3
?
J:
[18-239]
-----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
----
T
F
L
R
C
L
N
L
-
L
E
D
F
D
E
-
G
E
I
I
I
D
G
I
-----------
N
L
----------
K
A
K
D
T
-
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
--
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
--
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
-----
E
L
L
D
K
V
G
L
K
D
K
A
--
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
--
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
K
-----
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
64.65
36%
-118
- C3 -
2OLJ
3
?
B:
[39-260]
-----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
----
T
F
L
R
C
L
N
L
-
L
E
D
F
D
E
-
G
E
I
I
I
D
G
I
-----------
N
L
----------
K
A
K
D
T
-
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
--
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
--
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
-----
E
L
L
D
K
V
G
L
K
D
K
A
--
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
--
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
K
-----
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------