@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA1861: (2016-02-02 )
MDGLRLRFRRAYPGFELDIDLALPGRGVTALFGHSGSGKSTCLRCIAGLEKAAEGEVTINGETWQDSRRNLFVAPHRRALGYVFQDANLFRHLTVRRNLAFGLKRIAAAERRVELEQACALLGIEHLLERMPERLSGGEQQRVGIARALLTSPRLLLMDEPLASLDLKRKGEILPYLERLHEELDIPVLYVSHSPDEVARLADHLVLLENGKVRASGPIGETLARVDLPLALDDDAGVVIEGTVSDHDPAYGLLTLVLPGSALQMRVAHAPLAPGKRLRFKVQARDVSLNLRDDAQSSILNRLPVRVLELVDTDTAAHVLVRLDAGGNPLLARITRYSRDQLQLRPGQLLWAQIKSVAVLA
Atome Classification :
(22 SA)
-......-.-..10..-.--.-.---..-.20........30........40........50........60........70........80........90........100.---..--...--.110...---......120-----.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220...-....230-.-......240.......250.......260.......270.......280.....------..290------.......300.......310.......320.......330.......340.......350.......360
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MDG
L
R
L
-
R
-
F
R
RAYP-G--
F
-
E
---
L
D
-
I
D
L
ALPGRG
V
T
A
L
FGHSGS
G
K
S
T
C
L
R
C
I
A
G
L
E
K
AAEG
E
V
T
INGETWQDSRR
N
L
F
VAPHR
R
A
L
G
Y
V
F
Q
D
A
N
L
F
R
H
L
T
V
R
R
N
L
A
F
G
L
---
K
R
--
I
A
A
--
A
E
--
R
R
V
---
E
L
E
Q
A
C
A
L
L
-----
G
I
E
H
L
L
E
R
M
P
E
RLSGG
E
Q
Q
R
V
G
I
A
R
A
L
LTSP
R
L
L
L
MDEP
L
A
SL
D
L
KRKG
E
I
L
P
Y
L
E
R
L
H
E
ELDI
P
V
L
Y
VSH
S
P
D
E
V
A
R
L
A
D
H
L
V
L
L
EN
G
K
V
R
ASGPIG
E
T
L
A
R-VDL
P
L
A
L-D-DDA
G
V
V
I
E
G
TVSDHDPA
Y
G
L
L
T
L
V
LPGS
A
L
Q
M
R
VAHAPLAPG
K
R
L
R
F
K
V
Q
A
R
D
V
------
S
L
N
LR------D
D
A
Q
S
S
I
L
N
RL
P
V
R
V
L
E
LVDTDTA
A
H
V
L
V
R
L
DAGG
N
P
L
L
A
R
I
T
RYSRD
Q
L
QLRP
G
Q
L
L
W
A
Q
I
K
S
V
AVLA-
103
Fugue
93.19
27%
-111
- C1 -
1Z47
1
?
A:
[11-355]
G
S
M
T
I
E
F
-
V
G
V
E
K
I
Y
P
-
G
--
G
-
A
RSV
R
G
-
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
T
D
------
L
P
P
Q
K
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
L
---
R
E
K
R
V
P
K
--
D
E
--
M
D
A
---
R
V
R
E
L
L
R
F
M
-----
R
L
E
S
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
-
F
-
I
G
E
S
N
V
W
T
R
A
V
Q
N
G
R
I
E
V
A
G
A
A
L
P
V
D
----------
P
A
V
S
E
G
S
E
V
A
V
V
V
R
P
K
D
V
------
E
L
Q
P
A
------
S
E
------
R
E
A
H
A
Q
V
V
R
S
A
F
K
G
S
Y
S
A
C
W
I
R
T
-
K
D
G
E
V
W
E
V
H
V
P
--
S
A
D
R
H
R
W
S
P
G
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
24
PsiBlast_CBE
88.23
31%
-102
- C1 -
3D31
2
?
B:
[9-344]
------------
R
K
W
K
-
N
--
F
-
S
---
L
D
N
L
S
L
K
V
E
S
G
E
Y
F
V
I
L
G
P
T
G
A
G
K
T
L
F
L
E
L
I
A
G
F
H
V
P
D
S
G
R
I
L
L
D
G
K
D
V
T
D
------
L
S
P
E
K
H
D
I
A
F
V
Y
Q
N
Y
S
L
F
P
H
M
N
V
K
K
N
L
E
F
G
M
RM-
K
K
--
I
K
D
--
P
K
--
R
V
L
---
D
T
A
R
D
---
L
-----
K
I
E
H
L
L
D
R
N
P
L
T
L
S
G
G
E
Q
Q
R
V
A
L
A
R
A
L
V
T
N
P
K
I
L
L
L
D
E
P
L
S
A
L
D
P
R
T
Q
E
N
A
R
E
M
L
S
V
L
H
K
K
N
K
L
T
V
L
H
I
T
H
D
Q
T
E
A
R
I
M
A
D
R
I
A
V
V
M
D
G
K
L
I
Q
V
G
K
P
E
E
I
F
E
K
P
V
E
G
R
V
A
S
-
F
-
V
G
F
E
N
V
L
K
G
R
V
I
S
A
E
--
Q
G
L
L
R
I
R
V
G
E
V
V
I
D
---
A
A
G
D
M
E
V
G
D
Q
V
Y
A
F
L
R
P
E
N
I
------
A
L
S
-
K
------
S
S
T
Q
S
S
I
R
N
S
L
Q
G
R
V
T
E
A
--
W
V
L
G
A
L
V
R
V
K
V
D
C
-
G
V
P
L
N
V
L
I
T
R
R
S
A
E
E
M
E
L
S
P
G
V
Q
I
Y
A
R
F
K
A
S
S
V
H
V
-
2
PsiBlast_PDB
87.73
31%
-102
- C1 -
3D31
2
?
A:
[9-344]
------------
R
K
W
K
-
N
--
F
-
S
---
L
D
N
L
S
L
K
V
E
S
G
E
Y
F
V
I
L
G
P
T
G
A
G
K
T
L
F
L
E
L
I
A
G
F
H
V
P
D
S
G
R
I
L
L
D
G
K
D
V
T
D
------
L
S
P
E
K
H
D
I
A
F
V
Y
Q
N
Y
S
L
F
P
H
M
N
V
K
K
N
L
E
F
G
M
R
M
-
K
K
--
I
K
D
--
P
K
--
R
V
L
---
D
T
A
R
D
---
L
-----
K
I
E
H
L
L
D
R
N
P
L
T
L
S
G
G
E
Q
Q
R
V
A
L
A
R
A
L
V
T
N
P
K
I
L
L
L
D
E
P
L
S
A
L
D
P
R
T
Q
E
N
A
R
E
M
L
S
V
L
H
K
K
N
K
L
T
V
L
H
I
T
H
D
Q
T
E
A
R
I
M
A
D
R
I
A
V
V
M
D
G
K
L
I
Q
V
G
K
P
E
E
I
F
E
K
P
V
E
G
R
V
A
S
-
F
-
V
G
F
E
N
V
L
K
G
R
V
I
S
A
E
--
Q
G
L
L
R
I
R
V
G
E
V
V
I
D
---
A
A
G
D
M
E
V
G
D
Q
V
Y
A
F
L
R
P
E
N
I
------
A
L
S
-
K
------
S
S
T
Q
S
S
I
R
N
S
L
Q
G
R
V
T
E
A
--
W
V
L
G
A
L
V
R
V
K
V
D
C
-
G
V
P
L
N
V
L
I
T
R
R
S
A
E
E
M
E
L
S
P
G
V
Q
I
Y
A
R
F
K
A
S
S
V
H
V
-
111
HHSearch
87.04
30%
-109
- C1 -
3D31
2
?
A:
[1-345]
---
M
I
E
I
E
S
-
L
S
R
K
W
K
-
N
--
F
S
L
---
D
N
-
L
S
L
K
V
E
S
G
E
Y
F
V
I
L
G
P
T
G
A
G
K
T
L
F
L
E
L
I
A
G
F
H
V
P
D
S
G
R
I
L
L
D
G
K
D
V
T
D
------
L
S
P
E
K
H
D
I
A
F
V
Y
Q
N
Y
S
L
F
P
H
M
N
V
K
K
N
L
E
F
G
M
---
R
M
--
K
K
I
---
K
--
D
P
K
---
R
V
L
D
T
A
R
D
L
-----
K
I
E
H
L
L
D
R
N
P
L
T
L
S
G
G
E
Q
Q
R
V
A
L
A
R
A
L
V
T
N
P
K
I
L
L
L
D
E
P
L
S
A
L
D
P
R
T
Q
E
N
A
R
E
M
L
S
V
L
H
K
K
N
K
L
T
V
L
H
I
T
H
D
Q
T
E
A
R
I
M
A
D
R
I
A
V
V
M
D
G
K
L
I
Q
V
G
K
P
E
E
I
F
E
K
-
P
V
E
G
R
V
A
-
S
F
V
G
F
E
N
V
L
K
G
R
V
I
S
A
E
Q
G
--
L
L
R
I
R
V
--
G
E
V
V
I
D
A
A
-
G
D
M
E
V
G
D
Q
V
Y
A
F
L
R
P
E
N
I
------
A
L
S
K
S
------
S
T
-
Q
S
S
I
R
N
S
L
Q
G
R
V
T
E
A
W
V
-
L
G
A
-
L
V
R
V
K
V
D
C
G
-
V
P
L
N
V
L
I
T
R
R
S
A
E
E
M
E
L
S
P
G
V
Q
I
Y
A
R
F
K
A
S
S
V
H
V
-
118
HHSearch
86.03
27%
-104
- C1 -
1Z47
1
?
A:
[13-349]
--
M
T
I
E
F
V
G
-
V
E
K
I
Y
P
G
G
AR
S
-
V
---
R
G
-
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
T
D
------
L
P
P
Q
K
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
L
---
R
E
--
K
R
V
P
K
D
E
--
M
D
A
---
R
V
R
E
L
L
R
F
M
-----
R
L
E
S
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
-
P
G
T
L
F
V
A
-
S
F
I
G
E
S
N
V
W
T
R
A
V
Q
N
G
R
I
E
-----
V
A
----
G
A
A
L
P
V
D
-
P
A
V
S
E
G
S
E
V
A
V
V
V
R
P
K
D
V
------
E
L
Q
P
A
------
S
E
------
R
E
A
H
A
Q
V
V
R
S
A
F
-
K
G
S
-
Y
S
A
C
W
I
R
T
K
D
G
-
E
V
W
E
V
H
V
P
S
A
D
R
H
R
W
S
P
G
A
W
V
H
M
N
V
T
R
W
F
I
F
P
-
15
PsiBlast_PDB
85.84
32%
-113
- C1 -
3PUW
5
MALK_ECOLI
A:
[21-320]
---------------------------
D
-
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
---
K
---
L
A
G
--
A
K
--
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
-----
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
----------
A
Q
-
V
G
K
P
L
E
L
Y
H
-
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
S
R
D
V
QVG
A
N
M
S
L
G
I
R
PEHLLP
S
D
I
A
D
V
I
L
E
G
-
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-
16
PsiBlast_PDB
85.68
32%
-114
- C1 -
3PUX
5
MALK_ECOLI
A:
[21-320]
---------------------------
D
-
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
---
K
---
L
A
G
--
A
K
--
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
-----
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
----------
A
Q
-
V
G
K
P
L
E
L
Y
H
-
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
S
R
D
V
QVG
A
N
M
S
L
G
I
R
PEHLLP
S
D
I
A
D
V
I
L
E
G
-
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-
14
PsiBlast_PDB
85.48
32%
-114
- C1 -
3PUV
5
MALK_ECOLI
A:
[21-320]
---------------------------
D
-
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
---
K
---
L
A
G
--
A
K
--
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
-----
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
----------
A
Q
-
V
G
K
P
L
E
L
Y
H
-
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
S
R
D
V
QVG
A
N
M
S
L
G
I
R
PEHLLP
S
D
I
A
D
V
I
L
E
G
-
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-
17
PsiBlast_PDB
85.14
32%
-112
- C1 -
3RLF
3
MALK_ECOLI
A:
[21-320]
---------------------------
D
-
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
---
K
---
L
A
G
--
A
K
--
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
-----
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
----------
A
Q
-
V
G
K
P
L
E
L
Y
H
-
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
S
R
D
V
QVG
A
N
M
S
L
G
I
R
PEHLLP
S
D
I
A
D
V
I
L
E
G
-
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-
27
PsiBlast_CBE
84.72
32%
-115
- C1 -
3RLF
3
MALK_ECOLI
B:
[21-320]
---------------------------
D
-
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
---
K
---
L
A
G
--
A
K
--
K
E
V
INQ
R
V
N
Q
V
A
E
V
L
-----
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
----------
A
Q
-
V
G
K
P
L
E
L
Y
H
-
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
S
R
D
V
QVGANM
S
L
G
I
R
PEHLLP
S
D
I
A
D
V
I
L
E
G
-
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-
20
PsiBlast_PDB
84.33
32%
-111
- C1 -
4KI0
4
?
A:
[21-320]
---------------------------
D
-
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
---
K
---
L
A
G
--
A
K
--
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
-----
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
----------
A
Q
-
V
G
K
P
L
E
L
Y
H
-
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
S
R
D
V
QVG
A
N
M
S
L
G
I
R
PEHLLP
S
D
I
A
D
V
I
L
E
G
-
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-
26
PsiBlast_CBE
84.19
32%
-112
- C1 -
4KI0
3
?
B:
[21-320]
---------------------------
D
-
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
---
K
---
L
A
G
--
A
K
--
K
E
V
INQ
R
V
N
Q
V
A
E
V
L
-----
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
----------
A
Q
-
V
G
K
P
L
E
L
Y
H
-
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
S
R
D
V
QVGANM
S
L
G
I
R
PEHLLP
S
D
I
A
D
V
I
L
E
G
-
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-
11
PsiBlast_PDB
83.66
32%
-114
- C1 -
3PUY
3
MALK_ECOLI
A:
[21-320]
---------------------------
D
-
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
---
K
---
L
A
G
--
A
K
--
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
-----
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
----------
A
Q
-
V
G
K
P
L
E
L
Y
H
-
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
S
R
D
V
QVG
A
N
M
S
L
G
I
R
PEHLLP
S
D
I
A
D
V
I
L
E
G
-
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-
38
PsiBlast_CBE
83.52
32%
-107
- C1 -
2R6G
2
MALK_ECOLI (first)
A:
[21-320]
---------------------------
D
-
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
---
K
---
L
A
G
--
A
K
--
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
-----
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
Q
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
----------
A
Q
-
V
G
K
P
L
E
L
Y
H
-
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
S
R
D
V
QVG
A
N
M
S
L
G
I
R
PEHLLP
S
D
I
A
D
V
I
L
E
G
-
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-
33
PsiBlast_CBE
83.30
32%
-112
- C1 -
2AWN
2
MALK_ECOLI
B:
[21-320]
---------------------------
D
-
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
---
K
---
L
A
G
--
A
K
--
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
-----
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
----------
A
Q
-
V
G
K
P
L
E
L
Y
H
-
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
S
R
D
V
QVG
A
N
M
S
L
G
I
R
PEHLLP
S
D
I
A
D
V
I
L
E
G
-
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-
12
PsiBlast_PDB
83.30
32%
-109
- C1 -
3PUZ
2
MALK_ECOLI
A:
[21-320]
---------------------------
D
-
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
---
K
---
L
A
G
--
A
K
--
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
-----
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
----------
A
Q
-
V
G
K
P
L
E
L
Y
H
-
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
S
R
D
V
QVG
A
N
M
S
L
G
I
R
PEHLLP
S
D
I
A
D
V
I
L
E
G
-
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-
19
PsiBlast_PDB
83.29
32%
-110
- C1 -
4KHZ
-
?
A:
[21-320]
---------------------------
D
-
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
---
K
---
L
A
G
--
A
K
--
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
-----
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
----------
A
Q
-
V
G
K
P
L
E
L
Y
H
-
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
S
R
D
V
QVG
A
N
M
S
L
G
I
R
PEHLLP
S
D
I
A
D
V
I
L
E
G
-
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-
37
PsiBlast_CBE
83.20
32%
-109
- C1 -
2R6G
2
MALK_ECOLI (first)
B:
[21-320]
---------------------------
D
-
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
---
K
---
L
A
G
--
A
K
--
K
E
V
INQ
R
V
N
Q
V
A
E
V
L
-----
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
Q
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
----------
A
Q
-
V
G
K
P
L
E
L
Y
H
-
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
S
R
D
V
QVGANM
S
L
G
I
R
PEHLLP
S
D
I
A
D
V
I
L
E
G
-
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-
28
PsiBlast_CBE
83.19
32%
-113
- C1 -
3PUZ
2
MALK_ECOLI
B:
[21-320]
---------------------------
D
-
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
---
K
---
L
A
G
--
A
K
--
K
E
V
INQ
R
V
N
Q
V
A
E
V
L
-----
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
----------
A
Q
-
V
G
K
P
L
E
L
Y
H
-
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
S
R
D
V
QVGANM
S
L
G
I
R
PEHLLP
S
D
I
A
D
V
I
L
E
G
-
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-
35
PsiBlast_CBE
82.46
32%
-112
- C1 -
1Q12
2
MALK_ECOLI
C:
[21-320]
---------------------------
D
-
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
---
K
---
L
A
G
--
A
K
--
K
E
V
INQ
R
V
N
Q
V
A
E
V
L
-----
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
----------
A
Q
-
V
G
K
P
L
E
L
Y
H
-
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
S
R
D
V
QVGANM
S
L
G
I
R
PEHLLP
S
D
I
A
D
V
I
L
E
G
-
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-
99
PsiBlast_CBE
61.42
32%
-91
- C1 -
4AYX
2
ABCBA_HUMAN
A:
[358-571]
---------------
P
-
I
--
F
-
Q
----
D
-
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
----
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
-
S
C
S
I
A
E
N
I
A
Y
G
A
DDP
S
S
--
V
T
A
--
E
E
I
Q
R
V
A
---
E
V
A
N
A
V
A
F
I
R
N
FPQ
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
--
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
-
P
N
G
----------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
60.82
32%
-89
- C1 -
4AYT
2
ABCBA_HUMAN
A:
[358-567]
---------------
P
-
I
--
F
-
Q
----
D
-
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
----
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
-
S
C
S
I
A
E
N
I
A
Y
G
A
DDP
S
S
--
V
T
A
--
E
E
I
Q
R
V
A
---
E
V
A
N
A
V
A
F
I
R
N
FPQ
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
--
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------