@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA1865: (2016-02-02 )
MHEQYQAPLPVNSPALPEPFYYLHNFRAVLAWIGERYADLLDDQERAFIAAFAELPEASQALLVRMVMRKGTLFREGKLAYAEIGDTRAAVQPLLALGWVDAQPTLELAQLFGLLKKDELSQLFRDHLGRANLRKDALLERLQPLFPEARRLAEWQADFAEPVYELRCMALCDRLRLMYFGNLWQDWSEFVLADLGIYRYESVEFSADSRGFRLRADVDAYLHLFDCRQRFDLGEPLEELLAGLPGEPYANPWLEGRRVKLLFQFAQHCEKQRDFDLAQRLYRQSSHPGARLRAIRSLERGERFAEAHALAREASCAPESDAERQGLARLLPRLQGKLGLPRQARAAAPEIDRLDLCLAFPSEPCSVEWAVREHLEEPGCAVHYVENGLINSLFGLLCWEAIFAAIPGAFFHPFHSAPADLHSADFRQRRAALFEACLGRLEDGSYRDAIRCRYRDKFGLQSPFVYWELLGEELLEQALDCLPAAHLRAWFERLLEDIPGNRAGLPDLIQFWPAQRRYRMVEVKGPGDRLQDNQLRWLQFCREREMPVAVCYVRWHVDD
Atome Classification :
(20 SA)
.........10........20........30........--40........50........60........70........80....-....90........100....-...110.......120......-----.130.......140.......150.......160....---...170.......180....----------...190.......200.......210.......220.......230-------------.......240.......250--------------.......260.....--..270.......280.......290.-----......300.......310.......-320.......330.......----------340.......350.......--360.......370.......380.........390.......400..-.-....410.......420.......430.......440..---.....450.......460.......470........480-.........490.......500.......510.......520.......530.......540.......550.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MHEQYQAPLPVNSPALP
E
P
F
Y
Y
L
H
N
F
R
A
V
L
A
W
I
G
E
R
Y
A
D
--
L
LDD
Q
E
R
A
F
I
A
A
F
A
ELP
E
A
S
Q
A
L
L
V
R
M
V
M
R
KGTLFREG
K
L
A
Y
A
EIG-D
T
R
A
A
V
Q
P
L
L
A
LGWVDAQ
P
T
L
-
E
L
A
Q
L
F
G
L
L
K
K
D
E
L
S
Q
L
F
R
D
HL-----GRAN
L
R
K
D
A
L
L
E
R
L
Q
P
L
F
P
E
A
R
R
L
A
E
W
Q
A
D
F
A
E
P
V
Y
E
L
---
R
C
M
A
L
C
D
R
L
R
L
M
Y
F
G
N
L
W
Q
D
----------
W
S
E
F
V
L
A
D
LGI
Y
R
Y
E
S
V
E
FSADSRG
F
R
L
R
A
D
V
D
A
Y
L
H
L
F
D
C
R
Q
RFD-------------L
G
E
P
L
E
E
L
L
AGLPGEPYANP--------------WLEG
R
R
V
K
L
L
F
Q
F
A
Q
--
H
C
E
KQR
D
F
D
L
A
Q
R
L
Y
R
QSSHP
G
A
R
L
R
-----
A
I
R
S
L
E
R
G
E
R
F
A
E
A
H
A
L
A
R
EASCAPE-S
D
A
E
R
Q
G
L
A
R
L
L
P
R
L
Q
GKLG----------LPRQARAAAPEID
R
L
D
L
C
LA--FPSEPC
S
V
E
W
A
V
R
E
HLEEPG
C
--
A
V
H
Y
V
EN
G
L
I
N
S
L
F
G
L
L
C
W
E
A
I
F
A
-A-I
P
G
A
F
FHPFHSAPAD
L
H
S
A
D
F
R
Q
R
R
A
A
L
F
E
A
C
L
G
RLEDG---SYRD
A
I
R
C
R
YRDKFGLQS
P
F
V
Y
W
E
L
L
-
G
E
E
L
L
E
Q
A
L
D
---CL
P
A
A
H
L
R
A
W
F
E
R
L
L
E
DIPGNRAG
L
P
D
L
I
Q
FWPAQ
R
R
Y
R
M
V
E
VKGPGDRLQDNQ
L
R
W
L
Q
F
C
R
EREM
P
V
A
V
C
Y
V
R
W
H
VDD
42
Fugue
96.96
100%
-138
- C4 -
4R8A
3
FAN1_PSEAE
A:
[16-553]
---------------
L
P
E
P
F
Y
Y
L
H
N
F
R
A
V
L
A
W
I
G
E
R
Y
A
D
--
L
L
D
D
Q
E
R
A
F
I
A
A
F
A
E
L
P
E
A
S
Q
A
L
L
V
R
M
V
M
R
K
G
T
L
F
R
E
G
K
L
A
Y
A
E
I
G
-
D
T
R
A
A
V
Q
P
L
L
A
L
G
W
V
D
A
Q
P
T
L
-
E
L
A
Q
L
F
G
L
L
K
K
D
E
L
S
Q
L
F
R
D
H
L
-----
G
R
A
N
L
R
K
D
A
L
L
E
R
L
Q
P
L
F
P
E
A
R
R
L
A
E
W
Q
A
D
F
A
E
P
V
Y
E
L
---
R
C
M
A
L
C
D
R
L
R
L
M
Y
F
G
N
L
W
Q
D
----------
W
S
E
F
V
L
A
D
L
G
I
Y
R
Y
E
S
V
E
F
S
A
D
S
R
G
F
R
L
R
A
D
V
D
A
Y
L
H
L
F
D
C
R
Q
R
F
D
-------------
L
G
E
P
L
E
E
L
L
A
G
L
P
G
E
P
Y
A
N
P
--------------
W
L
E
G
R
R
V
K
L
L
F
Q
F
A
Q
--
H
C
E
K
Q
R
D
F
D
L
A
Q
R
L
Y
R
Q
S
S
H
P
G
A
R
L
R
-----
A
I
R
S
L
E
R
G
E
R
F
A
E
A
H
A
L
A
R
E
A
S
C
A
P
E
-
S
D
A
E
R
Q
G
L
A
R
L
L
P
R
L
Q
G
K
L
G
----------
L
P
R
Q
A
R
A
A
A
P
E
I
D
R
L
D
L
C
L
A
--
F
P
S
E
P
C
S
V
E
W
A
V
R
E
H
L
E
E
P
G
C
--
A
V
H
Y
V
E
N
G
L
I
N
S
L
F
G
L
L
C
W
E
A
I
F
A
-
A
-
I
P
G
A
F
F
H
P
F
H
S
A
P
A
D
L
H
S
A
D
F
R
Q
R
R
A
A
L
F
E
A
C
L
G
R
L
E
D
G
---
S
Y
R
D
A
I
R
C
R
Y
R
D
K
F
G
L
Q
S
P
F
V
Y
W
E
L
L
-
G
E
E
L
L
E
Q
A
L
D
---
C
L
P
A
A
H
L
R
A
W
F
E
R
L
L
E
D
I
P
G
N
R
A
G
L
P
D
L
I
Q
F
W
P
A
Q
R
R
Y
R
M
V
E
V
K
G
P
G
D
R
L
Q
D
N
Q
L
R
W
L
Q
F
C
R
E
R
E
M
P
V
A
V
C
Y
V
------
2
PsiBlast_PDB
96.96
100%
-138
- C4 -
4R8A
3
FAN1_PSEAE
A:
[16-553]
---------------
L
P
E
P
F
Y
Y
L
H
N
F
R
A
V
L
A
W
I
G
E
R
Y
A
D
--
L
L
D
D
Q
E
R
A
F
I
A
A
F
A
E
L
P
E
A
S
Q
A
L
L
V
R
M
V
M
R
K
G
T
L
F
R
E
G
K
L
A
Y
A
E
I
G
-
D
T
R
A
A
V
Q
P
L
L
A
L
G
W
V
D
A
Q
P
T
L
-
E
L
A
Q
L
F
G
L
L
K
K
D
E
L
S
Q
L
F
R
D
H
L
-----
G
R
A
N
L
R
K
D
A
L
L
E
R
L
Q
P
L
F
P
E
A
R
R
L
A
E
W
Q
A
D
F
A
E
P
V
Y
E
L
---
R
C
M
A
L
C
D
R
L
R
L
M
Y
F
G
N
L
W
Q
D
----------
W
S
E
F
V
L
A
D
L
G
I
Y
R
Y
E
S
V
E
F
S
A
D
S
R
G
F
R
L
R
A
D
V
D
A
Y
L
H
L
F
D
C
R
Q
R
F
D
-------------
L
G
E
P
L
E
E
L
L
A
G
L
P
G
E
P
Y
A
N
P
--------------
W
L
E
G
R
R
V
K
L
L
F
Q
F
A
Q
--
H
C
E
K
Q
R
D
F
D
L
A
Q
R
L
Y
R
Q
S
S
H
P
G
A
R
L
R
-----
A
I
R
S
L
E
R
G
E
R
F
A
E
A
H
A
L
A
R
E
A
S
C
A
P
E
-
S
D
A
E
R
Q
G
L
A
R
L
L
P
R
L
Q
G
K
L
G
----------
L
P
R
Q
A
R
A
A
A
P
E
I
D
R
L
D
L
C
L
A
--
F
P
S
E
P
C
S
V
E
W
A
V
R
E
H
L
E
E
P
G
C
--
A
V
H
Y
V
E
N
G
L
I
N
S
L
F
G
L
L
C
W
E
A
I
F
A
-
A
-
I
P
G
A
F
F
H
P
F
H
S
A
P
A
D
L
H
S
A
D
F
R
Q
R
R
A
A
L
F
E
A
C
L
G
R
L
E
D
G
---
S
Y
R
D
A
I
R
C
R
Y
R
D
K
F
G
L
Q
S
P
F
V
Y
W
E
L
L
-
G
E
E
L
L
E
Q
A
L
D
---
C
L
P
A
A
H
L
R
A
W
F
E
R
L
L
E
D
I
P
G
N
R
A
G
L
P
D
L
I
Q
F
W
P
A
Q
R
R
Y
R
M
V
E
V
K
G
P
G
D
R
L
Q
D
N
Q
L
R
W
L
Q
F
C
R
E
R
E
M
P
V
A
V
C
Y
V
------
10
PsiBlast_CBE
96.78
100%
-138
- C4 -
4R8A
3
FAN1_PSEAE
F:
[16-553]
---------------
L
P
E
P
F
Y
Y
L
H
N
F
R
A
V
L
A
W
I
G
E
R
Y
A
D
--
L
L
D
D
Q
E
R
A
F
I
A
A
F
A
E
L
P
E
A
S
Q
A
L
L
V
R
M
V
M
R
K
G
T
L
F
R
E
G
K
L
A
Y
A
E
I
G
-
D
T
R
A
A
V
Q
P
L
L
A
L
G
W
V
D
A
Q
P
T
L
-
E
L
A
Q
L
F
G
L
L
K
K
D
E
L
S
Q
L
F
R
D
H
L
-----
G
R
A
N
L
R
K
D
A
L
L
E
R
L
Q
P
L
F
P
E
A
R
R
L
A
E
W
Q
A
D
F
A
E
P
V
Y
E
L
---
R
C
M
A
L
C
D
R
L
R
L
M
Y
F
G
N
L
W
Q
D
----------
W
S
E
F
V
L
A
D
L
G
I
Y
R
Y
E
S
V
E
F
S
A
D
S
R
G
F
R
L
R
A
D
V
D
A
Y
L
H
L
F
D
C
R
Q
R
F
D
-------------
L
G
E
P
L
E
E
L
L
A
G
L
P
G
E
P
Y
A
N
P
--------------
W
L
E
G
R
R
V
K
L
L
F
Q
F
A
Q
--
H
C
E
K
Q
R
D
F
D
L
A
Q
R
L
Y
R
Q
S
S
H
P
G
A
R
L
R
-----
A
I
R
S
L
E
R
G
E
R
F
A
E
A
H
A
L
A
R
E
A
S
C
A
P
E
-
S
D
A
E
R
Q
G
L
A
R
L
L
P
R
L
Q
G
K
L
G
----------
L
P
R
Q
A
R
A
A
A
P
E
I
D
R
L
D
L
C
L
A
--
F
P
S
E
P
C
S
V
E
W
A
V
R
E
H
L
E
E
P
G
C
--
A
V
H
Y
V
E
N
G
L
I
N
S
L
F
G
L
L
C
W
E
A
I
F
A
-
A
-
I
P
G
A
F
F
H
P
F
H
S
A
P
A
D
L
H
S
A
D
F
R
Q
R
R
A
A
L
F
E
A
C
L
G
R
L
E
D
G
---
S
Y
R
D
A
I
R
C
R
Y
R
D
K
F
G
L
Q
S
P
F
V
Y
W
E
L
L
-
G
E
E
L
L
E
Q
A
L
D
---
C
L
P
A
A
H
L
R
A
W
F
E
R
L
L
E
D
I
P
G
N
R
A
G
L
P
D
L
I
Q
F
W
P
A
Q
R
R
Y
R
M
V
E
V
K
G
P
G
D
R
L
Q
D
N
Q
L
R
W
L
Q
F
C
R
E
R
E
M
P
V
A
V
C
Y
V
------
11
PsiBlast_CBE
94.02
100%
-132
- C4 -
4R89
5
FAN1_PSEAE
E:
[17-553]
----------------
P
E
P
F
Y
Y
L
H
N
F
R
A
V
L
A
W
I
G
E
R
Y
A
D
--
L
L
D
D
Q
E
R
A
F
I
A
A
F
A
E
L
P
E
A
S
Q
A
L
L
V
R
M
V
M
R
K
G
T
L
F
R
E
G
K
L
A
Y
A
E
I
G
-
D
T
R
A
A
V
Q
P
L
L
A
L
G
W
V
D
A
Q
P
T
L
-
E
L
A
Q
L
F
G
L
L
K
K
D
E
L
S
Q
L
F
R
D
H
L
-----
G
R
A
N
L
R
K
D
A
L
L
E
R
L
Q
P
L
F
P
E
A
R
R
L
A
E
W
Q
A
D
F
A
E
P
V
Y
E
L
---
R
C
M
A
L
C
D
R
L
R
L
M
Y
F
G
N
L
W
Q
D
----------
W
S
E
F
V
L
A
D
L
G
I
Y
R
Y
E
S
V
E
F
S
A
D
S
R
G
F
R
L
R
A
D
V
D
A
Y
L
H
L
F
D
C
R
Q
R
F
D
-------------
L
G
E
P
L
E
E
L
L
A
G
L
P
G
E
P
Y
A
N
P
--------------
W
L
E
G
R
R
V
K
L
L
F
Q
F
A
Q
--
H
C
E
K
Q
R
D
F
D
L
A
Q
R
L
Y
R
Q
S
S
H
P
G
A
R
L
R
-----
A
I
R
S
L
E
R
G
E
R
F
A
E
A
H
A
L
A
R
E
A
S
C
A
P
E
-
S
D
A
E
R
Q
G
L
A
R
L
L
P
R
L
Q
G
K
L
G
----------
L
P
R
Q
A
R
A
A
A
P
E
I
D
R
L
D
L
C
L
A
--
F
P
S
E
P
C
S
V
E
W
A
V
R
E
H
L
E
E
P
G
C
--
A
V
H
Y
V
E
N
G
L
I
N
S
L
F
G
L
L
C
W
E
A
I
F
A
-
A
-
I
P
G
A
F
F
H
P
F
H
S
A
P
A
D
L
H
S
A
D
F
R
Q
R
R
A
A
L
F
E
A
C
L
G
R
L
E
D
G
---
S
Y
R
D
A
I
R
C
R
Y
R
D
K
F
G
L
Q
S
P
F
V
Y
W
E
L
L
-
G
E
E
L
L
E
Q
A
L
D
---
C
L
P
A
A
H
L
R
A
W
F
E
R
L
L
E
D
I
P
G
N
R
A
G
L
P
D
L
I
Q
F
W
P
A
Q
R
R
Y
R
M
V
E
V
K
G
P
G
D
R
L
Q
D
N
Q
L
R
W
L
Q
F
C
R
E
R
E
M
P
V
A
V
C
Y
V
------
1
PsiBlast_PDB
93.85
100%
-133
- C4 -
4R89
5
FAN1_PSEAE
A:
[17-553]
----------------
P
E
P
F
Y
Y
L
H
N
F
R
A
V
L
A
W
I
G
E
R
Y
A
D
--
L
L
D
D
Q
E
R
A
F
I
A
A
F
A
E
L
P
E
A
S
Q
A
L
L
V
R
M
V
M
R
K
G
T
L
F
R
E
G
K
L
A
Y
A
E
I
G
-
D
T
R
A
A
V
Q
P
L
L
A
L
G
W
V
D
A
Q
P
T
L
-
E
L
A
Q
L
F
G
L
L
K
K
D
E
L
S
Q
L
F
R
D
H
L
-----
G
R
A
N
L
R
K
D
A
L
L
E
R
L
Q
P
L
F
P
E
A
R
R
L
A
E
W
Q
A
D
F
A
E
P
V
Y
E
L
---
R
C
M
A
L
C
D
R
L
R
L
M
Y
F
G
N
L
W
Q
D
----------
W
S
E
F
V
L
A
D
L
G
I
Y
R
Y
E
S
V
E
F
S
A
D
S
R
G
F
R
L
R
A
D
V
D
A
Y
L
H
L
F
D
C
R
Q
R
F
D
-------------
L
G
E
P
L
E
E
L
L
A
G
L
P
G
E
P
Y
A
N
P
--------------
W
L
E
G
R
R
V
K
L
L
F
Q
F
A
Q
--
H
C
E
K
Q
R
D
F
D
L
A
Q
R
L
Y
R
Q
S
S
H
P
G
A
R
L
R
-----
A
I
R
S
L
E
R
G
E
R
F
A
E
A
H
A
L
A
R
E
A
S
C
A
P
E
-
S
D
A
E
R
Q
G
L
A
R
L
L
P
R
L
Q
G
K
L
G
----------
L
P
R
Q
A
R
A
A
A
P
E
I
D
R
L
D
L
C
L
A
--
F
P
S
E
P
C
S
V
E
W
A
V
R
E
H
L
E
E
P
G
C
--
A
V
H
Y
V
E
N
G
L
I
N
S
L
F
G
L
L
C
W
E
A
I
F
A
-
A
-
I
P
G
A
F
F
H
P
F
H
S
A
P
A
D
L
H
S
A
D
F
R
Q
R
R
A
A
L
F
E
A
C
L
G
R
L
E
D
G
---
S
Y
R
D
A
I
R
C
R
Y
R
D
K
F
G
L
Q
S
P
F
V
Y
W
E
L
L
-
G
E
E
L
L
E
Q
A
L
D
---
C
L
P
A
A
H
L
R
A
W
F
E
R
L
L
E
D
I
P
G
N
R
A
G
L
P
D
L
I
Q
F
W
P
A
Q
R
R
Y
R
M
V
E
V
K
G
P
G
D
R
L
Q
D
N
Q
L
R
W
L
Q
F
C
R
E
R
E
M
P
V
A
V
C
Y
V
------
43
Fugue
70.09
25%
-108
- C4 -
4RIC
5
FAN1_HUMAN
A:
[1-631]
----------------
T
G
H
P
Y
Y
L
R
S
F
L
V
V
L
K
T
V
L
E
N
E
D
D
M
L
L
F
D
E
Q
E
K
G
I
V
T
K
F
Y
Q
L
S
A
T
G
Q
K
L
Y
V
R
L
F
Q
R
K
L
S
W
I
K
M
T
K
L
E
Y
E
E
I
A
L
D
L
T
P
V
I
E
E
L
T
N
A
G
F
L
Q
T
E
S
E
L
Q
E
L
S
E
V
L
E
L
L
S
A
P
E
L
K
S
L
A
K
T
F
H
LVNPN
G
Q
K
Q
Q
L
V
D
A
F
L
K
L
A
K
Q
R
S
V
I
G
A
V
I
L
K
R
A
K
A
L
A
G
Q
S
V
R
I
C
K
G
P
R
A
V
F
S
R
I
L
L
L
F
S
L
T
D
S
M
E
D
EDAACGGQGQ
L
S
T
V
L
L
V
N
L
G
R
M
E
F
P
S
Y
T
I
N
R
K
T
H
I
F
Q
D
R
D
D
L
I
R
Y
A
A
A
T
H
M
L
S
D
I
S
S
A
M
A
N
GN
W
E
E
A
K
E
L
A
Q
C
A
K
R
D
W
N
R
L
K
N
H
P
S
L
R
C
H
E
D
LP
L
F
L
R
C
F
T
V
G
W
I
Y
T
R
I
L
S
R
F
V
E
I
L
Q
R
L
H
M
Y
E
E
A
V
R
E
L
E
S
L
L
S
Q
R
I
Y
C
P
D
S
R
G
R
W
W
D
R
L
A
L
N
L
H
Q
H
L
K
R
L
E
P
T
I
K
C
I
T
E
G
L
A
D
P
E
V
R
T
G
H
R
L
S
L
Y
Q
R
A
V
R
L
R
E
S
P
S
CKKFKHLFQQ
L
P
E
M
A
V
Q
D
V
K
H
V
T
I
T
G
R
L
C
K
S
V
F
V
M
V
L
C
S
V
E
E
L
A
L
A
H
Y
R
R
S
G
F
D-
Q
G
I
H
G
E
G
S
T
F
S
T
L
Y
G
L
L
L
W
D
I
I
F
M
-
D
G
I
P
D
V
F
R
N
A
C
Q
A
F
P
L
D
L
C
T
D
S
F
F
T
S
R
R
P
A
L
E
A
R
L
Q
L
I
H
D
A
P
E
E
S
L
R
A
W
V
A
A
T
W
H
E
Q
E
G
R
V
A
S
L
V
S
W
D
R
F
T
S
L
Q
Q
A
Q
D
L
V
S
---
C
L
G
G
P
V
L
S
G
V
C
R
H
L
A
A
D
F
R
H
C
R
G
G
L
P
D
L
V
V
W
N
S
Q
S
R
H
F
K
L
V
E
V
K
G
P
N
D
R
L
S
H
K
Q
M
I
W
L
A
E
L
Q
K
L
G
A
E
V
E
V
C
H
V
V
A
V
---
7
PsiBlast_PDB
53.16
32%
-116
- C4 -
4RY3
-
FAN1_HUMAN
A:
[442-636]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
S
V
E
E
L
A
L
A
H
Y
R
R
S
G
F
DQ
G
I
H
G
-
E
G
S
T
F
S
T
L
Y
G
L
L
L
W
D
I
I
F
M
D
G
-
I
P
D
V
F
R
N
A
C
Q
A
F
P
L
D
L
C
T
D
S
F
F
T
S
R
R
P
A
L
E
A
R
L
Q
L
I
H
D
A
P
E
E
S
L
R
A
W
V
A
A
T
W
H
E
Q
E
G
R
V
A
S
L
V
S
W
D
R
F
-
T
S
--
L
Q
Q
A
Q
D
L
V
S
C
L
G
G
P
V
L
S
G
V
C
R
H
L
A
A
D
F
R
H
C
R
G
G
L
P
D
L
V
V
W
N
S
Q
S
R
H
F
K
L
V
E
V
K
G
P
N
D
R
L
S
H
K
Q
M
I
W
L
A
E
L
Q
K
L
G
A
E
V
E
V
C
H
V
V
A
V
G
G
S
17
PsiBlast_CBE
52.93
31%
-111
- C4 -
4REC
3
FAN1_HUMAN
A:
[442-636]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
S
V
E
E
L
A
L
A
H
Y
R
R
S
G
F
DQ
G
I
H
G
-
E
G
S
T
F
S
T
L
Y
G
L
L
L
W
D
I
I
F
M
D
G
-
I
P
D
V
F
R
N
A
C
Q
A
F
P
L
D
L
C
T
D
S
F
F
T
S
R
R
P
A
L
E
A
R
L
Q
L
I
H
D
A
P
E
E
S
L
R
A
W
V
A
A
T
W
H
E
Q
E
G
R
V
A
S
L
V
S
W
D
R
F
-
T
S
--
L
Q
Q
A
Q
D
L
V
S
C
L
G
G
P
V
L
S
G
V
C
R
H
L
A
A
D
F
R
H
C
R
G
G
L
P
A
L
V
V
W
N
S
Q
S
R
H
F
K
L
V
E
V
K
G
P
N
D
R
L
S
H
K
Q
M
I
W
L
A
E
L
Q
K
L
G
A
E
V
E
V
C
H
V
V
A
V
---
14
PsiBlast_CBE
52.33
32%
-116
- C4 -
4RI8
3
FAN1_HUMAN
B:
[446-640]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
S
V
E
E
L
A
L
A
H
Y
R
R
S
G
F
DQ
G
I
H
G
-
E
G
S
T
F
S
T
L
Y
G
L
L
L
W
D
I
I
F
M
D
G
-
I
P
D
V
F
R
N
A
C
Q
A
F
P
L
D
L
C
T
D
S
F
F
T
S
R
R
P
A
L
E
A
R
L
Q
L
I
H
D
A
PEE
S
L
R
A
W
V
A
A
T
W
H
E
Q
E
G
R
V
A
S
L
V
S
W
D
R
F
-
T
S
--
L
Q
Q
A
Q
D
LVS
C
L
G
G
P
V
L
S
G
V
C
R
H
L
A
A
D
F
R
H
C
R
G
G
L
P
D
L
V
V
W
N
S
Q
S
R
H
F
K
L
V
E
V
K
G
P
N
D
R
L
S
H
K
Q
M
I
W
L
A
E
L
Q
K
L
G
A
E
V
E
V
C
H
V
V
A
V
---
3
PsiBlast_PDB
52.29
32%
-114
- C4 -
4RI8
3
FAN1_HUMAN
A:
[446-640]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
S
V
E
E
L
A
L
A
H
Y
R
R
S
G
F
DQ
G
I
H
G
-
E
G
S
T
F
S
T
L
Y
G
L
L
L
W
D
I
I
F
M
D
G
-
I
P
D
V
F
R
N
A
C
Q
A
F
P
L
D
L
C
T
D
S
F
F
T
S
R
R
P
A
L
E
A
R
L
Q
L
I
H
D
A
P
E
E
S
L
R
A
W
V
A
A
T
W
H
E
Q
E
G
R
V
A
S
L
V
S
W
D
R
F
-
T
S
--
L
Q
Q
A
Q
D
L
V
S
C
L
G
G
P
V
L
S
G
V
C
R
H
L
A
A
D
F
R
H
C
R
G
G
L
P
D
L
V
V
W
N
S
Q
S
R
H
F
K
L
V
E
V
K
G
P
N
D
R
L
S
H
K
Q
M
I
W
L
A
E
L
Q
K
L
G
A
E
V
E
V
C
H
V
V
A
V
---
15
PsiBlast_CBE
52.23
32%
-116
- C4 -
4RI9
3
FAN1_HUMAN
B:
[447-641]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
S
V
E
E
L
A
L
A
H
Y
R
R
S
G
F
DQ
G
I
H
G
-
E
G
S
T
F
S
T
L
Y
G
L
L
L
W
D
I
I
F
M
D
G
-
I
P
D
V
F
R
N
A
C
Q
A
F
P
L
D
L
C
T
D
S
F
F
T
S
R
R
P
A
L
E
A
R
L
Q
L
I
H
D
A
PEE
S
L
R
A
W
V
A
A
T
W
H
E
Q
E
G
R
V
A
S
L
V
S
W
D
R
F
-
T
S
--
L
Q
Q
A
Q
D
LVS
C
L
G
G
P
V
L
S
G
V
C
R
H
L
A
A
D
F
R
H
C
R
G
G
L
P
D
L
V
V
W
N
S
Q
S
R
H
F
K
L
V
E
V
K
G
P
N
D
R
L
S
H
K
Q
M
I
W
L
A
E
L
Q
K
L
G
A
E
V
E
V
C
H
V
V
A
V
---
20
PsiBlast_CBE
52.22
31%
-109
- C4 -
4REA
1
FAN1_HUMAN
B:
[442-636]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
S
V
E
E
L
A
L
A
H
Y
R
R
S
G
F
DQ
G
I
H
G
-
E
G
S
T
F
S
T
L
Y
G
L
L
L
W
D
I
I
F
M
D
G
-
I
P
D
V
F
R
N
A
C
Q
A
F
P
L
D
L
C
T
D
S
F
F
T
S
R
R
P
A
L
E
A
R
L
Q
L
I
H
D
A
P
E
E
S
L
R
A
W
V
A
A
T
W
H
E
Q
E
G
R
V
A
S
L
V
S
W
D
R
F
-
T
S
--
L
Q
Q
A
Q
D
L
V
S
C
L
G
G
P
V
L
S
G
V
C
R
H
L
A
A
D
F
R
H
C
R
G
G
L
P
A
L
V
V
W
N
S
Q
S
R
H
F
K
L
V
E
V
K
G
P
N
D
R
L
S
H
K
Q
M
I
W
L
A
E
L
Q
K
L
G
A
E
V
E
V
C
H
V
V
A
V
---
9
PsiBlast_PDB
51.85
32%
-114
- C4 -
4RID
-
FAN1_HUMAN
A:
[443-637]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
S
V
E
E
L
A
L
A
H
Y
R
R
S
G
F
DQ
G
I
H
G
-
E
G
S
T
F
S
T
L
Y
G
L
L
L
W
D
I
I
F
M
D
G
-
I
P
D
V
F
R
N
A
C
Q
A
F
P
L
D
L
C
T
D
S
F
F
T
S
R
R
P
A
L
E
A
R
L
Q
L
I
H
D
A
P
E
E
S
L
R
A
W
V
A
A
T
W
H
E
Q
E
G
R
V
A
S
L
V
S
W
D
R
F
-
T
S
--
L
Q
Q
A
Q
D
L
V
S
C
L
G
G
P
V
L
S
G
V
C
R
H
L
A
A
D
F
R
H
C
R
G
G
L
P
D
L
V
V
W
N
S
Q
S
R
H
F
K
L
V
E
V
K
G
P
N
D
R
L
S
H
K
Q
M
I
W
L
A
E
L
Q
K
L
G
A
E
V
E
V
C
H
V
V
A
V
---
8
PsiBlast_PDB
51.82
32%
-115
- C4 -
4RIC
3
FAN1_HUMAN
A:
[434-628]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
S
V
E
E
L
A
L
A
H
Y
R
R
S
G
F
DQ
G
I
H
G
-
E
G
S
T
F
S
T
L
Y
G
L
L
L
W
D
I
I
F
M
D
G
-
I
P
D
V
F
R
N
A
C
Q
A
F
P
L
D
L
C
T
D
S
F
F
T
S
R
R
P
A
L
E
A
R
L
Q
L
I
H
D
A
P
E
E
S
L
R
A
W
V
A
A
T
W
H
E
Q
E
G
R
V
A
S
L
V
S
W
D
R
F
-
T
S
--
L
Q
Q
A
Q
D
L
V
S
C
L
G
G
P
V
L
S
G
V
C
R
H
L
A
A
D
F
R
H
C
R
G
G
L
P
D
L
V
V
W
N
S
Q
S
R
H
F
K
L
V
E
V
K
G
P
N
D
R
L
S
H
K
Q
M
I
W
L
A
E
L
Q
K
L
G
A
E
V
E
V
C
H
V
V
A
V
---
5
PsiBlast_PDB
51.77
32%
-114
- C4 -
4RIA
3
FAN1_HUMAN
A:
[446-640]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
S
V
E
E
L
A
L
A
H
Y
R
R
S
G
F
DQ
G
I
H
G
-
E
G
S
T
F
S
T
L
Y
G
L
L
L
W
D
I
I
F
M
D
G
-
I
P
D
V
F
R
N
A
C
Q
A
F
P
L
D
L
C
T
D
S
F
F
T
S
R
R
P
A
L
E
A
R
L
Q
L
I
H
D
A
P
E
E
S
L
R
A
W
V
A
A
T
W
H
E
Q
E
G
R
V
A
S
L
V
S
W
D
R
F
-
T
S
--
L
Q
Q
A
Q
D
L
V
S
C
L
G
G
P
V
L
S
G
V
C
R
H
L
A
A
D
F
R
H
C
R
G
G
L
P
D
L
V
V
W
N
S
Q
S
R
H
F
K
L
V
E
V
K
G
P
N
D
R
L
S
H
K
Q
M
I
W
L
A
E
L
Q
K
L
G
A
E
V
E
V
C
H
V
V
A
V
---
13
PsiBlast_CBE
51.60
32%
-115
- C4 -
4RIA
3
FAN1_HUMAN
B:
[446-640]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
S
V
E
E
L
A
L
A
H
Y
R
R
S
G
F
DQ
G
I
H
G
-
E
G
S
T
F
S
T
L
Y
G
L
L
L
W
D
I
I
F
M
D
G
-
I
P
D
V
F
R
N
A
C
Q
A
F
P
L
D
L
C
T
D
S
F
F
T
S
R
R
P
A
L
E
A
R
L
Q
L
I
H
D
A
PEE
S
L
R
A
W
V
A
A
T
W
H
E
Q
E
G
R
V
A
S
L
V
S
W
D
R
F
-
T
S
--
L
Q
Q
A
Q
D
LVS
C
L
G
G
P
V
L
S
G
V
C
R
H
L
A
A
D
F
R
H
C
R
G
G
L
P
D
L
V
V
W
N
S
Q
S
R
H
F
K
L
V
E
V
K
G
P
N
D
R
L
S
H
K
Q
M
I
W
L
A
E
L
Q
K
L
G
A
E
V
E
V
C
H
V
V
A
V
---
6
PsiBlast_PDB
51.57
32%
-115
- C4 -
4RI9
3
FAN1_HUMAN
A:
[447-641]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
S
V
E
E
L
A
L
A
H
Y
R
R
S
G
F
DQ
G
I
H
G
-
E
G
S
T
F
S
T
L
Y
G
L
L
L
W
D
I
I
F
M
D
G
-
I
P
D
V
F
R
N
A
C
Q
A
F
P
L
D
L
C
T
D
S
F
F
T
S
R
R
P
A
L
E
A
R
L
Q
L
I
H
D
A
P
E
E
S
L
R
A
W
V
A
A
T
W
H
E
Q
E
G
R
V
A
S
L
V
S
W
D
R
F
-
T
S
--
L
Q
Q
A
Q
D
L
V
S
C
L
G
G
P
V
L
S
G
V
C
R
H
L
A
A
D
F
R
H
C
R
G
G
L
P
D
L
V
V
W
N
S
Q
S
R
H
F
K
L
V
E
V
K
G
P
N
D
R
L
S
H
K
Q
M
I
W
L
A
E
L
Q
K
L
G
A
E
V
E
V
C
H
V
V
A
V
---
16
PsiBlast_CBE
51.56
32%
-115
- C4 -
4RIC
1
FAN1_HUMAN
B:
[434-628]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
S
V
E
E
L
A
L
A
H
Y
R
R
S
G
F
DQ
G
I
H
G
-
E
G
S
T
F
S
T
L
Y
G
L
L
L
W
D
I
I
F
M
D
G
-
I
P
D
V
F
R
N
A
C
Q
A
F
P
L
D
L
C
T
D
S
F
F
T
S
R
R
P
A
L
E
A
R
L
Q
L
I
H
D
A
P
E
E
S
L
R
A
W
V
A
A
T
W
H
E
Q
E
G
R
V
A
S
L
V
S
W
D
R
F
-
T
S
--
L
Q
Q
A
Q
D
L
V
S
C
L
G
G
P
V
L
S
G
V
C
R
H
L
A
A
D
F
R
H
C
R
G
G
L
P
D
L
V
V
W
N
S
Q
S
R
H
F
K
L
V
E
V
K
G
P
N
D
R
L
S
H
K
Q
M
I
W
L
A
E
L
Q
K
L
G
A
E
V
E
V
C
H
V
V
A
V
---
4
PsiBlast_PDB
51.19
32%
-110
- C4 -
4RIB
3
FAN1_HUMAN
A:
[446-640]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
S
V
E
E
L
A
L
A
H
Y
R
R
S
G
F
DQ
G
I
H
G
-
E
G
S
T
F
S
T
L
Y
G
L
L
L
W
D
I
I
F
M
D
G
-
I
P
D
V
F
R
N
A
C
Q
A
F
P
L
D
L
C
T
D
S
F
F
T
S
R
R
P
A
L
E
A
R
L
Q
L
I
H
D
A
P
E
E
S
L
R
A
W
V
A
A
T
W
H
E
Q
E
G
R
V
A
S
L
V
S
W
D
R
F
-
T
S
--
L
Q
Q
A
Q
D
L
V
S
C
L
G
G
P
V
L
S
G
V
C
R
H
L
A
A
D
F
R
H
C
R
G
G
L
P
D
L
V
V
W
N
S
Q
S
R
H
F
K
L
V
E
V
K
G
P
N
D
R
L
S
H
K
Q
M
I
W
L
A
E
L
Q
K
L
G
A
E
V
E
V
C
H
V
V
A
V
---
12
PsiBlast_CBE
50.56
32%
-112
- C4 -
4RIB
1
FAN1_HUMAN
B:
[446-640]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
S
V
E
E
L
A
L
A
H
Y
R
R
S
G
F
DQ
G
I
H
G
-
E
G
S
T
F
S
T
L
Y
G
L
L
L
W
D
I
I
F
M
D
G
-
I
P
D
V
F
R
N
A
C
Q
A
F
P
L
D
L
C
T
D
S
F
F
T
S
R
R
P
A
L
E
A
R
L
Q
L
I
H
D
A
P
E
E
S
L
R
A
W
V
A
A
T
W
H
E
Q
E
G
R
V
A
S
L
V
S
W
D
R
F
-
T
S
--
L
Q
Q
A
Q
D
L
V
S
C
L
G
G
P
V
L
S
G
V
C
R
H
L
A
A
D
F
R
H
C
R
G
G
L
P
D
L
V
V
W
N
S
Q
S
R
H
F
K
L
V
E
V
K
G
P
N
D
R
L
S
H
K
Q
M
I
W
L
A
E
L
Q
K
L
G
A
E
V
E
V
C
H
V
V
A
V
---