@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA1893: (2016-02-02 )
MSKNARYAWRLSLGGLLLGLLACAVYLLAVPLGFKYGEIQVGHGLEHEGRIAWDAAGVPHIRAQSLEDGYFLLGYSHARDRLWQMEFARRYAGGTLSEVFGAKTLPMDRFARTLGFRRTAEGIYANLDAPTRVLLQRYSDGINAYLELAPAALPLEFSLVRHERPGPWGPVDSLSLHLLYSWTLSANLGMQLQRLALAEHLDLARINEVFAPYPGERPPATRDYASLYRSLHGTPDAGKLLGQLPGSNVEGIGSNNWVVSASRSATGKPLLANDPHLRLTNPAAFYLASLKIPGLSLTGANFAGAPLFVIGHNQRIAWGYTNTGSHIQDAYLERVDPQDPRRYLTPDGYRPFETRLERIAVRDGETVSLEVRSTRHGPVISDIYEPARLPQAQRDRLVIALAWTGLDRHDKTFPSLLAINRAEGWEQFLDAAANFGVPPQNMVYADVEGNIGYVSAGRVPLRGADDDLHGLAPSPGWESRYDWVGYVPESAKPRSLNPREGFIATANQRIVPPDNAFDFGHDWVLPYRYDRIREWLGGPGQRTLEDSLELQNDEFSSVMASLLPKMLEQVSDPELRASEAFALLQGWNHQAAADLAAPLIAGYWVRAFTRELLQPRIGTQLLASGWNQRNYDGFLRLILDGQADLRFWCGQEQGCDLKLNQSLRRALDELRAAHGSAPSGWKWGEAHAALAEHVPFHKTPLRALFDLKNNKGGDNFSVNVGRFDYSDPANPFNTRIAATLRMVIDLADFDNSRYALSTRNSGLPFDGATDLNELWARGAYIRIADDAPDATDRQLVLRPSASSSGEPRP
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------.........-----10........20.....---------...30........40.........50........60......---..70........80--------------.........90........100...-----....110.......120.......130.......-140.......150.......160.-------......170...-.--------...180..----------------.....190.......------200-........-210.......220...------....230.-......240.......250.-------......260...----....270......-.280-..-.....290.......300......-.-310....-..--------------.320..-.....330..-------------....-----------------------------------.340.......350.......360..--..----.-...--.370-----------........380...---------....390.......400........-.410----.-.....----.-420-.........430.-..-....440.......450...-....460.....-----..470.....--------..480...--------....490.-----......500.....---.---------.510..---------....--.520.-......530----..----......-.540...--.------...-.550--...--...------------.---..--560......-..570---.--.-.....580-.-......--.---.590----..-------.-------....--.600--------.......610-...----.---....620.--.------------.-------...----------.630-.----....-...---.640......---.---650---.--........660.......670------------.......680..-----------.-...-.690.......700.--....--..-710.......720------------.........730.......740.--------......-750...-....760-------------...---.-----..-..-.770..-----------.-----....780------..---......790-.....-..------..800.......-----------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------MSKNA
R
Y
A
W
-----
R
L
S
L
G
G
L
L
L
G
L
L
A
C
A
V
Y
---------
L
L
A
VPLG
F
K
YG
E
I
Q
-VGHGLEHE
G
R
I
A
WDAAGVP
H
I
RAQSLE---D
G
Y
F
L
L
G
Y
S
H
A
R
D
---------------
R
L
W
Q
M
E
F
A
R
R
YAGG
T
L
S
E
V
FGAKTL-----
P
M
D
R
F
A
R
T
LGFRRTAE
G
I
Y
ANLD
A
P
T
R
V
L
L
Q
R
Y
S-D
G
I
N
A
Y
L
E
LAPAAL
P
L
E
F
S
L
V
RHE-------RPGPWGPVDS
L
S
-
L
--------
H
L
L
Y
S
W
TL----------------SAN
L
G
M
Q
L
Q
R
L
A
L
A
E
------
H
L
--
D
L
A
R
I
N
E
V
-FAPYPGERPPAT
R
D
Y
A
------
S
L
Y
R
S
LHG-TP
D
A
G
K
L
L
G
QLPGSNVEGIG-------SN
N
W
V
V
SASRSA----TGKPLLANDP
H
L
R
-LTNP-A
A
-
F
Y
L
A
S
LKIP
G
L
S
LTGANFAG
A
P
L
F
-
V
-
I
GHN
Q
R
I
-
A
W
--------------
G
YTNTG-
S
H
I
Q
D
A
Y
L
ER-------------VDPQ-----------------------------------DPRRYLTPDGYR
P
F
E
T
R
L
E
R
I
A--VR--DG----
E
-
T
V
S
--
L
E
V
------------RSTRHG
P
V
I
S
D
IYE---------PARLPQAQR
D
R
L
V
I
A
--
L
A
WTGLDR-HDKT----
F
-
P
S
L
L
A
----
I
-
N
---
R
A
E
G
W
E
Q
F
L
D
A
A
A-NF-GVPPQN
M
V
Y
A
DVEGN
I
G
Y
V
S-AGRVPLRGADDD-----LHGLAPSPGW--------ESRY
D
W
VG--------YVPESAKP-----RSLNPRE
G
F
I
ATAN---Q---------RIVPPD---------NAFD--FGHDW-VL
P
Y
R
Y
D
------
R
I
----
R
E
W
LGG-PGQ-
R
T
L
--
E
------
D
S
L-EL----QN
D
--
E
F
S
------------
S
---
V
M
--
A
S
-
L
L
P
K
M
L
-
E
QVSD---P--
E
-
L
R
A
S
E
A
---
F
-
A
L
L
QGW--N---
H
Q
A
-----
A
A
-------
D
-------
L
A
A
P
--
L
I
A
G
--------
Y
W
V
R
A
F
T
R
E
--
L
LQ----P---RI
G
T
Q
L
L
A
--S------------G-------WNQ----------R
N
---
Y
----
D
G
F
L
-
R
L
I
---LDGQA
D
L
R
F
W
---C---G-----Q--EQGC
D
L
K
L
N
Q
S
L
R
R
A
L
D
E
L
R
A
------------AHGSAPSGWKW
G
-----------
E
-
A
H
A
-
A
L
A
EHVPFHK
T
P
L
R
A
--
L
F
D
L--KN-NKGGDN
F
S
V
N
V--------------GRFDYSDPANP
F
N
T
R
I
A
A
T
L
R
M
V
--------
I
D
LADF-DNS
R
Y
A
-
L
STRN---------------SGL---P-----FD-GA-T
D
L
N
E
L
-----------W-----ARG
A
Y
I
-------
R
I---ADDAPDA---TD
R
Q
L
-
V
L------RPSASSSGEPRP-----------------------------------
1
PsiBlast_PDB
93.17
29%
-44
- C8 -
4HST
1
?
B:
[1-533]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
N
W
A
V
A
P
G
R
T
A
----
T
G
R
P
I
L
A
G
D
P
H
R
V
-
F
E
I
P
-
G
F
-
Y
A
Q
H
H
L
A
C
D
R
F
D
M
I
G
L
T
V
P
G
V
P
G
F
P
S
-
F
A
H
N
G
K
V
-
A
Y
--------------
C
V
T
S
A
F
-
M
D
I
H
D
L
Y
L
E
Q
-------------
F
A
G
E
-----------------------------------
G
-
R
T
A
R
F
G
N
D
F
E
P
V
A
W
S
R
D
R
I
A
--
V
R
--
G
G
----
A
-
D
R
E
--
F
D
I
------------
V
E
T
R
H
G
P
V
I
A
G
--
D
---------
P
-------
R
D
G
A
A
L
T
--
L
R
S
V
Q
F
A
E
-
T
D
L
S
----
F
-
D
C
L
T
R
----
M
-
P
---
G
A
S
T
V
A
Q
L
Y
D
A
T
R
-
G
W
-
G
L
I
D
H
N
L
V
A
G
D
V
A
G
S
I
G
H
L
V
-
R
A
R
V
P
S
R
P
R
E
N
--------
G
W
L
P
V
P
G
W
--------
S
G
E
H
E
W
R
G
--------
W
I
P
H
E
A
M
P
-----
R
V
I
D
P
P
G
G
I
I
V
T
A
N
---
N
---------
R
V
V
A
D
D
---------
H
P
D
Y
--
L
C
T
D
C
-
H
P
P
Y
R
A
E
------
R
I
----
M
K
R
L
V
A
-
N
P
A
-
F
A
V
--
D
------
D
A
A
-
A
I
----
H
A
D
--
T
L
S
------------
P
----
H
--
V
G
-
L
L
R
R
R
L
-
E
A
L
G
A
---
R
--
D
-
D
S
A
A
E
G
---
L
R
Q
M
L
V
A
W
--
D
---
G
R
-------
M
-------
D
-------
A
A
S
E
--
V
A
S
A
--------
Y
--
N
A
F
R
R
A
--
L
-------------
T
R
L
V
T
D
R
S
------------
G
-------
L
E
Q
----------
A
I
---
S
----
H
P
F
A
-
A
V
A
---
P
G
V
S
P
Q
G
Q
V
W
---
W
---
A
V
P
T
L
L
R
--
D
D
D
A
G
M
L
K
G
W
S
W
D
Q
A
L
S
E
A
L
S
------------
V
A
S
Q
N
L
T
G
R
S
W
G
-----------
E
-
E
H
R
-
P
R
F
T
H
P
L
A
T
Q
F
P
A
W
A
GL
L
N
P
A
--
S
R
-
P
I
G
G
D
G
D
T
V
L
A
--------------
N
G
L
V
P
S
--
A
G
P
Q
A
T
-
Y
G
A
L
S
R
Y
V
--------
F
D
V
G
N
W
-
D
N
S
R
W
V
-
V
F
H
G
A
---------------
S
G
H
---
P
-----
A
S
-
A
H
Y
A
D
Q
N
A
P
-----------
W
-----
S
D
C
A
M
V
PMLYS
W
D
R
I
---
A
A
E
A
--
V
---
T
S
Q
E
L
-
V
P
------
A
----------------------------------------------
2
PsiBlast_PDB
93.02
29%
-44
- C8 -
4HSR
1
?
B:
[1-533]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
N
W
A
V
A
P
G
R
T
A
----
T
G
R
P
I
L
A
G
D
P
H
R
V
-
F
E
I
P
-
G
F
-
Y
A
Q
H
H
L
A
C
D
R
F
D
M
I
G
L
T
V
P
G
V
P
G
F
-
P
H
F
A
H
N
G
K
V
-
A
Y
--------------
C
V
T
H
A
F
-
M
D
I
H
D
L
Y
L
E
Q
-------------
F
A
G
E
-----------------------------------
G
-
R
T
A
R
F
G
N
D
F
E
P
V
A
W
S
R
D
R
I
A
--
V
R
--
G
G
----
A
-
D
R
E
--
F
D
I
------------
V
E
T
R
H
G
P
V
I
A
G
--
D
---------
P
-------
R
D
G
A
A
L
T
--
L
R
S
V
Q
F
A
E
-
T
D
L
S
----
F
-
D
C
L
T
R
----
M
-
P
---
G
A
S
T
V
A
Q
L
Y
D
A
T
R
-
G
W
-
G
L
I
D
H
N
L
V
A
G
D
V
A
G
S
I
G
H
L
V
-
R
A
R
V
P
S
R
P
R
E
N
--------
G
W
L
P
V
P
G
W
--------
S
G
E
H
E
W
R
G
--------
W
I
P
H
E
A
M
P
-----
R
V
I
D
P
P
G
G
I
I
V
T
A
N
---
N
---------
R
V
V
A
D
D
---------
H
P
D
Y
--
L
C
T
D
C
-
H
P
P
Y
R
A
E
------
R
I
----
M
K
R
L
V
A
-
N
P
A
-
F
A
V
--
D
------
D
A
A
-
A
I
----
H
A
D
--
T
L
S
------------
P
----
H
--
V
G
-
L
L
R
R
R
L
-
E
A
L
G
A
---
R
--
D
-
D
S
A
A
E
G
---
L
R
Q
M
L
V
A
W
--
D
---
G
R
-------
M
-------
D
-------
A
A
S
E
--
V
A
S
A
--------
Y
--
N
A
F
R
R
A
--
L
-------------
T
R
L
V
T
D
R
S
------------
G
-------
L
E
Q
----------
A
I
---
S
----
H
P
F
A
-
A
V
A
---
P
G
V
S
P
Q
G
Q
V
W
---
W
---
A
V
P
T
L
L
R
--
D
D
D
A
G
M
L
K
G
W
S
W
D
Q
A
L
S
E
A
L
S
------------
V
A
S
Q
N
L
T
G
R
S
W
G
-----------
E
-
E
H
R
-
P
R
F
T
H
P
L
A
T
Q
F
P
A
W
A
GL
L
N
P
A
--
S
R
-
P
I
G
G
D
G
D
T
V
L
A
--------------
N
G
L
V
P
S
--
A
G
P
Q
A
T
-
Y
G
A
L
S
R
Y
V
--------
F
D
V
G
N
W
-
D
N
S
R
W
V
-
V
F
H
G
A
---------------
S
G
H
---
P
-----
A
S
-
A
H
Y
A
D
Q
N
A
P
-----------
W
-----
S
D
C
A
M
V
PMLYS
W
D
R
I
---
A
A
E
A
--
V
---
T
S
Q
E
L
-
V
P
------
A
----------------------------------------------
6
PsiBlast_PDB
89.63
26%
-57
- C8 -
3S8R
1
?
A:
[20-524]
--------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
W
D
G
Y
G
V
P
H
I
Y
G
V
D
A
P
---
S
A
F
Y
G
Y
G
W
A
Q
A
R
S
---------------
H
G
D
N
I
L
R
L
Y
G
E
A
R
G
K
G
A
E
Y
W
G
P
D
Y
E
-----
Q
T
T
V
W
L
L
T
N
G
V
P
E
R
A
Q
Q
W
Y
A
Q
Q
S
P
D
F
R
A
N
L
D
A
F
A
-
A
G
I
N
A
Y
A
Q
Q
N
P
D
D
I
S
P
D
---
V
R
Q
V
-------
L
P
--------------------------
V
S
----------------
G
A
D
V
V
A
H
A
H
R
L
------------------
M
N
F
L
-
Y
V
A
S
P
G
------------------------------
R
T
L
G
E
G
D
P
P
D
L
A
D
Q
G
-------
A
N
S
W
A
V
A
P
G
K
T
A
----
N
G
N
A
L
L
L
Q
N
P
H
L
S
W
T
T
D
Y
-
F
T
-
Y
Y
E
A
H
L
V
T
P
D
F
E
I
Y
G
A
T
Q
I
G
L
P
V
I
-
R
-
F
A
F
N
Q
R
M
-----------------
G
I
T
N
T
V
-
N
G
M
V
G
A
T
N
Y
R
-------------
L
T
L
Q
-----------------------------------
D
-
G
G
Y
L
Y
D
G
Q
V
R
P
F
E
R
P
Q
A
S
Y
R
--
L
R
Q
A
D
G
----
T
-
T
V
D
K
P
L
E
I
------------
R
S
S
V
H
G
P
V
F
E
--------------------
R
A
D
G
T
A
V
A
--
V
R
V
A
G
L
D
R
--
P
G
M
----
L
-
E
Q
Y
F
D
----
M
-
I
---
T
A
D
S
F
D
D
Y
E
A
A
L
A
-
R
M
-
Q
V
P
T
F
N
I
V
Y
A
D
R
E
G
T
I
N
Y
S
F
-
N
G
V
A
P
K
R
A
E
G
D
I
-----
A
F
W
Q
G
L
V
P
G
D
--------
S
S
R
Y
L
W
T
E
--------
T
H
P
L
D
D
L
P
-----
R
V
T
N
P
P
G
G
F
V
Q
N
S
N
---
D
------------
P
P
----------------
W
T
P
T
W
-
P
V
T
Y
T
P
K
------
D
F
----
P
S
Y
L
A
P
-
Q
T
P
-
H
S
L
R
A
Q
------
Q
S
V
-
R
L
M
S
--
E
N
D
--
D
L
T
L
E
R
F
M
A
L
Q
L
SHR
A
---
V
M
--
A
D
R
T
L
P
D
L
I
P
A
A
L
I
D
---
P
--
D
-
P
E
V
Q
A
A
---
A
-
R
L
L
A
A
W
--
D
---
R
E
F
-----
T
S
-------
D
-------
S
R
A
A
--
L
L
F
E
--------
E
W
A
R
L
F
A
G
Q
--
N
F
A
----
G
---
Q
A
G
F
A
T
P
W
--
S
------------
L
-------
D
K
P
----------
V
S
---
T
----
P
Y
G
V
-
R
D
P
---
K
A
A
V
D
Q
L
R
T
A
---
I
---
A
-----
N
--
T
K
R
K
Y
G
A
I
D
R
P
F
G
D
A
S
R
M
I
L
N
------------
D
V
N
V
P
G
A
A
G
Y
G
N
-----------
L
-
G
S
F
-
R
V
F
T
W
S
D
P
D
E
N
G
V
R
T
--
P
V
H
G
--
E
T
-
W
V
A
M
I
E
F
S
T
P
V
--------------
R
A
Y
G
L
M
S
Y
G
N
S
R
Q
P
G
T
T
H
Y
S
D
Q
I
--------
E
R
V
S
R
A
-
D
F
R
E
L
L
-
L
R
R
E
Q
---------------
V
E
A
---
A
-----
V
Q
-
E
R
-
T
P
F
N
F
-----------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
88.80
26%
-54
- C8 -
1KEH
-
?
A:
[20-524]
--------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
W
D
G
Y
G
V
P
H
I
Y
G
V
D
A
P
---
S
A
F
Y
G
Y
G
W
A
Q
A
R
S
---------------
H
G
D
N
I
L
R
L
Y
G
E
A
R
G
K
G
A
E
Y
W
G
P
D
Y
E
-----
Q
T
T
V
W
L
L
T
N
G
V
P
E
R
A
Q
Q
W
Y
A
Q
Q
S
P
D
F
R
A
N
L
D
A
F
A
-
A
G
I
N
A
Y
A
Q
Q
N
P
D
D
I
S
P
E
---
V
R
Q
V
-------
L
P
--------------------------
V
S
----------------
G
A
D
V
V
A
H
A
H
R
L
------------------
M
N
F
L
-
Y
V
A
S
P
G
------------------------------
R
T
L
G
E
G
D
P
P
D
L
A
D
Q
G
-------
A
N
S
W
A
V
A
P
G
K
T
A
----
N
G
N
A
L
L
L
Q
N
P
H
L
S
W
T
T
D
Y
-
F
T
-
Y
Y
E
A
H
L
V
T
P
D
F
E
I
Y
G
A
T
Q
I
G
L
P
V
I
-
R
-
F
A
F
N
Q
R
M
-----------------
G
I
T
N
T
V
-
N
G
M
V
G
A
T
N
Y
R
-------------
L
T
L
Q
-----------------------------------
D
-
G
G
Y
L
Y
D
G
Q
V
R
P
F
E
R
R
Q
A
S
Y
R
--
L
R
Q
A
D
G
----
S
-
T
V
D
K
P
L
E
I
------------
R
S
S
V
H
G
P
V
F
E
--------------------
R
A
D
G
T
A
V
A
--
V
R
V
A
G
L
D
R
--
P
G
M
----
L
-
E
Q
Y
F
D
----
M
-
I
---
T
A
H
S
F
D
D
Y
E
A
A
M
A
-
R
M
-
Q
V
P
T
F
N
I
V
Y
A
D
R
E
G
T
I
N
Y
S
F
-
N
G
V
A
P
K
R
A
E
G
D
I
-----
A
F
W
Q
G
N
V
P
G
D
--------
S
S
R
Y
L
W
T
E
--------
T
H
P
L
D
D
L
P
-----
R
V
T
N
P
P
G
G
F
V
Q
N
S
N
---
D
PPWTPTWPV
T
Y
C
P
A
N
---------
H
P
S
Y
--
L
A
P
Q
T
-
P
H
S
L
R
A
Q
------
Q
S
----
V
R
L
M
S
E
-
N
D
D
-
L
T
L
--
E
------
R
F
M
-
A
L
----
Q
F
S
--
H
R
A
------------
V
---
M
A
--
D
R
-
T
L
P
D
L
I
P
A
A
L
I
D
---
P
--
D
-
P
E
V
Q
A
A
---
A
-
R
L
L
A
A
W
--
D
---
R
D
F
-----
T
S
-------
D
-------
S
R
A
A
--
L
L
F
E
--------
E
W
A
R
L
F
A
G
Q
--
N
F
A
----
G
---
Q
A
A
F
A
T
P
W
--
S
------------
L
-------
D
K
P
----------
V
S
---
T
----
P
Y
G
V
-
R
D
P
---
K
A
A
V
D
Q
L
R
T
A
---
I
---
A
-----
N
--
T
K
R
K
Y
G
A
I
D
R
P
F
G
D
A
S
R
M
I
L
N
------------
D
V
N
V
P
G
A
A
G
Y
G
N
-----------
L
-
G
S
F
-
R
V
F
T
W
S
D
P
D
E
N
G
I
R
T
--
P
V
H
G
--
E
T
-
W
V
A
M
I
E
F
S
T
P
V
--------------
R
A
Y
G
L
M
S
Y
G
N
S
R
Q
P
G
T
T
H
Y
S
D
Q
I
--------
E
R
V
S
R
A
-
D
F
R
E
L
L
-
L
R
R
E
Q
---------------
V
E
A
---
A
-----
V
Q
-
E
R
-
T
P
F
N
F
-----------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
88.41
27%
-58
- C8 -
4E57
13
?
A:
[22-520]
--------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
W
D
G
Y
G
V
P
H
I
Y
G
V
D
A
P
---
S
A
F
Y
G
Y
G
W
A
Q
A
R
S
---------------
H
G
D
N
I
L
R
L
Y
G
E
A
R
G
K
G
A
E
Y
W
G
P
D
Y
E
-----
Q
T
T
V
W
L
L
T
N
G
V
P
E
R
A
Q
Q
W
Y
A
Q
Q
S
P
D
F
R
A
N
L
D
A
F
A
-
A
G
I
N
A
Y
A
Q
Q
N
P
D
D
I
S
P
E
---
V
R
Q
V
-------
L
P
--------------------------
V
S
----------------
G
A
D
V
V
A
H
A
H
R
L
------------------
M
N
F
L
-
Y
V
A
S
P
G
-------------------
R
T
L
-
G
-
E
G
D
P
G
----------------------
A
N
S
W
A
V
A
P
G
K
T
A
----
N
G
N
A
L
L
L
Q
N
P
H
L
S
W
T
T
D
Y
-
F
T
-
Y
Y
E
A
H
L
V
T
P
D
F
E
I
Y
G
A
T
Q
I
G
L
P
V
I
-
R
-
F
A
F
N
Q
R
M
-----------------
G
I
T
N
T
V
-
N
G
M
V
G
A
T
N
Y
R
-------------
L
T
L
Q
-----------------------------------
D
-
G
G
Y
L
Y
D
G
Q
V
R
P
F
E
R
R
Q
A
S
Y
R
--
L
R
Q
A
D
G
----
T
-
T
V
D
K
P
L
E
I
------------
R
S
S
V
H
G
P
V
F
E
--------------------
R
A
D
G
T
A
V
A
--
V
R
V
A
G
L
D
R
--
P
G
M
----
L
-
E
Q
Y
F
D
----
M
-
I
---
T
A
D
S
F
D
D
Y
E
A
A
L
A
-
R
M
-
Q
V
P
T
F
N
I
V
Y
A
D
R
E
G
T
I
N
Y
S
F
-
N
G
V
A
P
K
R
A
E
G
D
I
-----
A
F
W
Q
G
L
V
P
G
D
--------
S
S
R
Y
L
W
T
E
--------
T
H
P
L
D
D
L
P
-----
R
V
T
N
P
P
G
G
F
V
Q
N
S
N
---
D
------------
P
P
----------------
W
T
P
T
W
-
P
V
T
Y
T
P
K
------
D
F
----
P
S
Y
L
A
P
-
Q
T
P
-
H
S
L
R
A
Q
------
Q
S
V
-
R
L
M
S
--
E
N
D
--
D
L
T
L
E
R
F
M
A
L
Q
L
SHR
A
---
V
M
--
A
D
R
T
L
P
D
L
I
P
A
A
L
I
D
---
P
--
D
-
P
E
V
Q
A
A
---
A
-
R
L
L
A
A
W
--
D
---
R
E
F
-----
T
S
-------
D
-------
S
R
A
A
--
L
L
F
E
--------
E
W
A
R
L
F
A
G
Q
--
N
F
A
----
G
---
Q
A
G
F
A
T
P
W
--
S
------------
L
-------
D
K
P
----------
V
S
---
T
----
P
Y
G
V
-
R
D
P
---
K
A
A
V
D
Q
L
R
T
A
---
I
---
A
-----
N
--
T
K
R
K
Y
G
A
I
D
R
P
F
G
D
A
S
R
M
I
L
N
------------
D
V
N
V
P
G
A
A
G
Y
G
N
-----------
L
-
G
S
F
-
R
V
F
T
W
S
D
P
D
E
N
G
V
R
T
--
P
V
H
G
--
E
T
-
W
V
A
M
I
E
F
S
T
P
V
--------------
R
A
Y
G
L
M
S
Y
G
N
S
R
Q
P
G
T
T
H
Y
S
D
Q
I
--------
E
R
V
S
R
A
-
D
F
R
E
L
L
-
L
R
R
E
Q
---------------
V
E
A
---
A
-----
V
Q
-
E
R
-
T
P
F
N
F
-----------------------------------------------------------------------------------------------------------
76
HHSearch
85.10
22%
-57
* C6 *
1CP9
3
?
B:
[1-539]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
V
W
L
V
G
K
T
K
A
S
----
G
A
K
A
I
L
L
N
G
P
Q
F
G
-
W
F
N
P
-
A
Y
-
T
Y
G
I
G
L
H
G
A
G
F
N
I
V
G
N
T
P
F
A
Y
P
A
I
-
L
-
F
G
H
N
G
H
V
-
S
W
--------------
G
S
T
A
G
F
-
G
D
G
V
D
I
F
A
E
Q
-------------
V
S
P
E
-----------------------------------
D
P
N
S
Y
L
H
Q
G
Q
W
K
K
M
L
S
R
Q
E
T
L
N
--
V
K
--
G
E
----
Q
-
P
I
T
--
F
E
I
------------
Y
R
T
V
H
G
N
V
V
K
R
D
K
T
---------
T
-------
H
T
A
Y
S
K
A
--
R
A
W
D
G
K
E
L
---
T
S
----
L
-
M
A
W
V
K
----
Q
-
G
---
Q
A
Q
N
W
Q
Q
W
L
D
Q
A
Q
--
N
-
Q
A
L
T
I
N
W
Y
Y
A
D
K
D
G
N
I
G
Y
V
H
-
T
G
H
Y
P
D
R
Q
I
N
H
-------
D
P
R
L
P
V
S
G
T
---------
G
E
W
D
W
K
G
--------
I
Q
P
F
A
N
N
P
-----
K
V
Y
N
P
K
S
G
Y
I
A
N
W
N
---
N
---------
S
P
A
K
-
N
---------
Y
P
A
S
DL
F
A
F
L
W
-
G
S
A
D
R
V
K
------
E
I
----
D
N
R
I
E
A
-
Y
D
K
-
L
T
A
--
D
------
D
M
W
-
A
I
L
Q
--
Q
T
S
--
R
V
D
------------
L
---
N
H
--
R
L
-
F
T
P
F
L
T
-
Q
A
T
Q
G
---
L
PS
N
-
D
N
S
V
K
L
---
V
-
S
M
L
Q
Q
W
--
D
---
G
I
N
-----
Q
L
-------
S
SDGKHYI
H
P
G
S
--
A
I
L
D
--------
I
W
L
K
E
M
L
K
A
--
T
L
G
----
Q
---
T
V
P
A
P
F
-
D
--
K
WYLASG------
Y
ETTQEGP
T
G
S
----------
L
N
---
I
----
S
T
G
A
-
K
L
L
Y
E
S
L
L
-
E
-
D
K
S
P
I
---
S
QSI
D
-----
L
FS
G
Q
P
Q
N
D
V
I
R
K
T
L
N
T
T
Y
Q
K
M
I
E
------------
K
Y
G
D
N
P
A
N
W
Q
T
P
-----------
A
-
T
A
L
-
T
F
R
E
N
N
F
F
G
I
--------------
P
Q
A
L
P
Q
E
N
F
H
Q
N
----------------
E
---------
Y
--
H
N
R
G
T
E
N
D
L
--------
I
V
F
T
E
E
G
V
S
A
W
D
V
-
V
A
P
G
Q
---------------
S
G
F
---
I
SPQGK
P
S
P
H
Y
-
Q
D
Q
L
S
L
-----------
Y
-----
Q
Q
F
G
K
K
-------
P
L
---
W
L
N
S
E
D
V
---
A
P
Y
I
E
-
S
T
------
E
T
L
I
I
E
R
----------------------------------------
74
HHSearch
84.25
22%
-60
- C6 -
3K3W
1
?
B:
[1-535]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
L
W
S
T
R
P
E
R
V
Q
----
E
G
S
T
V
L
I
N
G
P
Q
F
G
-
W
Y
N
P
-
A
Y
-
T
Y
G
I
G
L
H
G
A
G
F
D
V
V
G
N
T
P
F
A
Y
P
I
V
-
L
-
F
G
T
N
S
E
I
-
A
W
--------------
G
A
T
A
G
P
-
Q
D
V
V
D
I
Y
Q
E
K
-------------
L
N
P
S
-----------------------------------
R
A
D
Q
Y
W
F
N
N
A
W
R
T
M
E
Q
R
K
E
R
I
Q
--
V
R
--
G
Q
----
A
-
D
R
E
--
M
T
I
------------
W
R
T
V
H
G
P
V
M
Q
F
D
Y
D
------------------
Q
G
A
A
Y
S
K
K
R
S
W
D
G
Y
E
V
---
Q
S
----
L
-
L
A
W
L
N
----
V
-
A
---
K
A
R
N
W
T
E
F
L
D
Q
A
S
-
K
M
-
A
-
I
S
I
N
W
Y
Y
A
D
K
H
G
N
I
G
Y
V
S
-
P
A
F
L
P
Q
R
P
A
D
Q
-------
D
I
R
V
P
A
K
G
D
---------
G
S
M
E
W
L
G
--------
I
K
S
F
D
A
I
P
-----
K
A
Y
N
P
P
Q
G
Y
L
V
N
W
N
---
N
---------
K
P
A
P
D
K
---------
T
N
-
T
--
D
T
Y
Y
W
-
T
Y
G
D
R
M
N
------
E
L
----
V
S
Q
Y
Q
Q
-
K
D
L
-
F
S
V
--
Q
------
E
I
W
-
E
F
----
N
Q
K
AS
Y
S
D
------------
V
---
N
W
--
R
Y
-
F
R
P
H
L
E
-
K
L
A
Q
Q
---
L
PA
D
-
D
S
S
K
A
A
---
L
-
T
M
L
L
A
W
--
D
---
G
M
E
QDQGG
Q
N
-------
A
-------
G
P
A
R
--
V
L
F
K
--------
T
W
L
E
E
M
Y
K
Q
--
V
L
M
----
P
---
V
V
P
E
S
H
-
R
--
A
------------
M
-------
Y
S
Q
T
G
F
A
T
QQGPN
P
G
---
S
INLS
M
G
T
K
-
V
L
L
R
A
L
V
L
E
A
H
P
D
P
K
R
---
V
---
N
-----
V
FG
E
R
S
S
Q
E
I
M
H
T
A
L
Q
N
A
Q
A
R
L
S
Q
------------
E
Q
G
A
Q
M
A
R
W
T
M
P
-----------
T
S
V
H
R
-
F
S
D
K
N
F
T
-------------
G
--
T
P
Q
T
M
P
G
N
T
F
A
F
T
-------------------------
G
Y
Q
N
R
G
T
E
N
N
R
V
V
--------
F
D
A
K
G
V
--
E
F
C
D
A
-
M
P
P
G
Q
---------------
S
G
F
---
T
DRN
G
V
R
S
P
H
Y
-
E
D
Q
L
K
L
-----------
Y
-----
E
N
F
E
C
K
-------
T
M
---
D
V
T
H
A
D
I
---
R
R
N
A
Q
-
S
S
------
T
M
L
L
I
Q
P
Q
P
--------------------------------------
75
HHSearch
81.75
21%
-48
- C6 -
1GK9
22
?
B:
[1-554]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
M
W
V
I
G
K
S
K
A
Q
----
D
A
K
A
I
M
V
N
G
P
Q
F
G
-
W
Y
A
P
-
A
Y
-
T
Y
G
I
G
L
H
G
A
G
Y
D
V
T
G
N
T
P
F
A
Y
P
G
L
-
V
-
F
G
H
N
G
V
I
-
S
W
--------------
G
S
T
A
G
F
-
G
D
D
V
D
I
F
A
E
R
-------------
L
S
A
E
-----------------------------------
K
P
G
Y
Y
L
H
N
G
K
W
V
K
M
L
S
R
E
E
T
I
T
--
V
K
--
N
G
----
Q
-
A
E
T
--
F
T
V
------------
W
R
T
V
H
G
N
I
L
Q
T
D
Q
T
---------
T
-------
Q
T
A
Y
A
K
S
--
R
A
W
D
G
K
E
V
---
A
S
----
L
-
L
A
W
T
H
----
Q
-
M
---
K
A
K
N
W
Q
E
W
T
Q
Q
A
A
--
K
-
Q
A
L
T
I
N
W
Y
Y
A
D
V
N
G
N
I
G
Y
V
H
-
T
G
A
Y
P
D
R
Q
S
G
H
-------
D
P
R
L
P
V
P
G
T
---------
G
K
W
D
W
K
G
--------
L
L
P
F
E
M
N
P
-----
K
V
Y
N
P
Q
S
G
Y
I
A
N
W
N
---
N
---------
S
P
Q
K
-
D
---------
Y
P
A
S
DL
F
A
F
L
W
-
G
G
A
D
R
V
T
------
E
I
----
D
R
L
L
E
Q
-
K
P
R
-
L
T
A
--
D
------
Q
A
W
-
D
V
I
R
--
Q
T
S
--
R
Q
D
------------
L
---
N
L
--
R
L
-
F
L
P
T
L
Q
-
A
A
T
S
G
---
L
TQ
S
-
D
P
R
R
Q
L
---
V
-
E
T
L
T
R
W
--
D
---
G
I
N
-----
L
L
N
DDGKTW
Q
-------
Q
P
G
S
--
A
I
L
N
--------
V
W
L
T
S
M
L
K
R
--
T
V
V
----
A
---
A
V
P
M
P
F
D
K
--
W
YSASGYETTQDG
P
-------
T
G
S
----------
L
N
---
I
-----
S
V
G
A
K
I
L
Y
E
A
V
Q
-
G
-
D
K
S
P
I
PQA
V
---
D
-----
L
FA
G
K
P
Q
Q
E
V
V
L
A
A
L
E
D
T
W
E
T
L
S
K
------------
R
Y
G
N
N
V
S
N
W
K
T
P
-----------
A
-
M
A
L
-
T
F
R
A
N
N
F
F
G
V
----------------
P
Q
A
A
A
E
E
T
R
H
Q
--------------
A
E
Y
Q
N
R
-
G
T
E
N
D
M
I
V
F
S
P
T
T
S
-------------
D
R
P
-
V
L
A
W
D
V
-
V
A
P
G
Q
---------------
S
G
F
---
I
APDGT
V
D
K
H
Y
-
E
D
Q
L
K
M
-----------
Y
-----
E
N
F
G
R
K
-------
S
L
---
W
L
T
K
Q
D
V
E
A
H
K
E
S
Q
E
-
V
L
------
H
V
Q
R
-------------------------------------------
90
Fugue
78.31
18%
-32
- C5 -
2IPC
-
SECA_THET8
A:
[1-939]
-------------------------------------------MLGL
L
R
R
L
F
DN
N
E
R
E
I
A
R
Y
Y
K
Q
V
V
E
P
V
N
R
L
E
A
E
V
E
K
LPD
L
A
A
A
Y
R
E
L
K
E
K
H
E
K
-----
G
A
S
L
D
E
L
L
P
M
A
F
A
L
T
R
E
---------
S
A
K
R
Y
L
G
M
R
H
F
D
V
Q
L
I
G
G
A
V
L
H
E
G
K
I
A
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M
K
T
G
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G
K
T
L
V
A
T
L
A
---
V
A
L
N
A
L
T
G
K
G
V
H
V
---------------
V
T
V
N
D
Y
L
A
R
R
D
A
E
W
-
M
G
P
V
Y
R
G
L
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L
-----
S
V
G
V
I
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H
A
---
S
T
P
A
E
R
R
K
A
Y
L
A
D
V
T
Y
V
T
N
S
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L
G
F
D
Y
L
R
D
N
M
A
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S
P
D
Q
L
V
L
-----
R
H
D
-------
H
P
L
H
Y
A
I
I
D
E
V
D
-
S
ILIDEAR
T
P
L
I
I
S
G
P
A
----------------
E
K
A
T
D
L
Y
Y
K
M
A
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A
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------
K
L
--
E
R
G
L
P
A
E
------
P
G
V
R
K
E
P
T
G
D
Y
T
VEEKNR
S
V
H
L
T
L
Q
G
-
I
A
K
A
E
K
L
L
G
I
E
G
L
F
S
P
E
N
M
E
-------
L
A
H
M
L
I
Q
A
I
R
A
K
E
LYH
R
D
R
D
Y
I
V
Q
D
G
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V
I
-
I
V
D
E
-
F
T
-
G
R
L
M
P
G
R
R
Y
G
E
G
L
H
Q
A
I
E
A
K
E
G
V
R
-
I
-
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R
E
N
Q
T
L
-
A
T
I
T
YQNFFRLYE
K
R
A
G
M
T
G
T
A
-
K
T
E
E
K
E
F
Q
E
I
YG
M
D
V
V
VVPTNRP
V
I
R
K
-----------------------------------
D
F
P
D
V
V
Y
R
T
E
K
G
K
F
Y
A
V
V
E
E
I
A
E
K
Y
E
--
R
G
----
Q
-
P
V
L
--
V
G
T
------------
I
S
I
E
K
S
E
R
L
S
Q
M
L
K
---------
E
P
R
L
Y
L
P
R
L
E
M
R
L
E
L
--
F
K
K
A
S
Q
K
Q
-
Q
G
P
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----
W
-
E
R
L
R
K
L---
L
-
E
---
R
P
A
Q
L
K
D
E
D
L
A
P
F
-
E
G
-
L
I
P
P
K
G
N
L
R
T
A
W
E
G
L
K
R
A
V
H
-
T
L
A
V
L
R
Q
G
I
P
--------
H
Q
V
L
N
A
K
H
H
--------
A
R
E
A
E
I
V
A
Q
AGRSK
T
V
T
I
A
T
N
M
A
G
-----
R
G
T
D
I
K
L
G
G
N
P
E
Y
L
---
A
---------
A
A
L
L
E
K
---------
E
G
F
D
---
R
Y
E
W
-
K
V
E
L
F
I
K
------
K
M
----
V
A
---
G
-
K
E
E
-
E
A
R
--
A
------
L
A
Q
-
E
L
---------
G
I
R
------------
E
---
E
L
--
L
E
-
R
I
R
E
I
R
-
E
E
C
K
Q
---
D
--
E
-
E
R
V
R
A
L
GGL
F
-
I
I
G
T
E
R
--
H
---
E
S
R
-----
R
I
-------
D
-------
N
Q
L
R
--
G
R
A
G
RQG
D
P
G
G
S
R
F
Y
V
S
F
D
D
D
--
L
M
R
LFAS
D
---
R
V
I
A
M
L
D
R
--
M
------------
G
-------
F
D
D
----------
S
E
P
I
E
H
----
P
M
V
T
-
R
S
I
---
E
R
A
Q
K
R
V
E
D
R
---
N
---
F
-----
A
--
I
R
K
Q
L
L
Q
F
D
D
V
L
S
R
Q
R
E
V
I
Y
A
------------
Q
R
R
L
I
L
L
G
-
K
D
E
-----------
E
-
V
K
E
-
A
A
I
G
M
V
E
E
T
V
A
S
L
A
E
--
N
F
L
---
N
P
-
E
V
H
P
E
D
W
D
L
E
G
--------------
L
K
A
T
L
L
D
T
A
P
Q
L
Q
D
F
P
F
A
E
L
R
A
L
--------
K
A
E
E
A
V
-
E
R
L
V
E
A
-
A
L
K
A
Y
---------------
E
A
R
---
E
-----
A
E
-
L
S
-
P
P
L
M
R
A
-----------
V
-----
E
R
F
V
I
L
-------
N
V
---
V
D
N
A
W
K
E
---
H
L
H
N
L
D
V
L
------
R
Q
G
I
F
L
R
G
Y
G
Q
K
D
P
F
Q
E
Y
K
I
E
A
T
R
L
F
N
E
M
V
A
F
I
K
S
E
V
A
K
F
L
F
R
LKVE
89
Fugue
76.19
19%
-50
- C3 -
4M5D
14
UTP22_YEAST
A:
[81-1237]
T
A
T
E
S
Y
D
I
H
I
A
R
E
T
A
E
L
F
K
S
N
I
F
K
L
Q
I
D
E
L
L
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Q
V
KLK
Q
K
H
V
L
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V
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F
L
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L
Y
D
I
L
Q
E
I
P
D
W
E
EKS
L
A
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D
S
F
F
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NKIVSVPFVDPKP
I
P
Q
N
T
N
Y
K
F
N
Y
K
K
P
D
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L
I
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F
A
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L
K
A
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G
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D
T
L
L
T
M
P
K
E
L
F
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K
D
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-
L
N
F
R
C
L
H
K
-
R
S
V
Y
L
A
Y
L
T
H
H
L
L
I
L
L
K
K
D
KL
D
S
F
L
Q
L
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Y
S
Y
F
D
N
DPL
L
P
I
L
R
I
S
C
S
KDY
N
F
Y
K
T
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I
N
L
L
I
G
F
P
Y
K
V
F
E
P
K
K
L
-----
L
P
N
R
N
C
I
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I
-
L
P
A
T
P
L
Y
N
F
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L
S
S
S
T
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E
N
Y
L
K
Y
L
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T
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F
V
E
A
T
V
L
G
R
L
W
L
Q
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GFSSNMS
H
S
G
S
L
G
G
F
G
T
F
E
-
F
--------
T
I
L
M
A
A
L
L
N
GGGINSNKILLHGFS
S
Y
Q
L
F
K
G
V
I
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Y
L
A
T
M
DLCHD
G
H
L
--
Q
F
H
S
N
P
A
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K
Y
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F
Q
T
P
T
L
F
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------
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V
N
I
L
T
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M
T
V
S
S
Y
Q
I
L
K
E
Y
A
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E
T
L
R
M
L
N
NVVQDQF
S
N
I
F
L
T
N
I
S
R
F
D
----
N
L
K
Y
D
L
C
Y
D
V
Q
L
P
-
L
-
G
K
-
Y
N
-
N
L
E
T
S
L
A
A
T
F
G
S
M
E
R
V
K
F
I
T
L
E
N
F
-
L
-
A
H
K
I
T
N
V
-
A
R
--------------
Y
A
L
--
G
-
D
R
I
K
Y
I
Q
I
E
M
-------------
V
G
Q
K
SDFPITKRKVYSNTGGNHFNFD
F
V
R
V
K
L
IVNPSEC
D
K
L
V
T
K
G
P
A
H
S
E
T
M
S
T
E
A
A
V
F
K
--
N
F
--
W
G
----
I
-
K
S
S
--
L
R
R
F
KDG
S
I
T
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C
C
V
W
S
T
S
S
S
E
P
I
I
S
S
I
V
N
F
A
L
Q
K
HVSK
K
A
Q
I
S
N
E
T
I
K
K
F
H
N
F
--
L
P
L
P
N
L
P
S
-
S
A
K
T
SVLN
L
-
S
S
F
F
N
----
L
-
K
---
K
S
--
F
D
D
L
Y
K
I
I
F
-
Q
M
-
K
L
P
L
S
V
K
S
I
L
P
V
G
S
A
F
R
Y
T
S
L
C
Q
P
V
P
F
A
Y
S
D
P
D
F
F
Q
D
V
I
L
E
F
E
T
S
P
K
W
PDE
I
T
S
L
E
K
A
K
T
A
F
L
L
--------
K
I
Q
E
E
L
S
A
NSST
Y
R
S
F
F
S
R
D
E
S
I
P
Y
N
L
---
E
I
V
T
L
-----
N
I
L
T
P
E
------------
G
--
Y
G
F
K
F
R
V
L
T
E
R
D
E
------
I
L
----
Y
L
R
A
I
A
-
N
A
R
-
N
E
L
--
K
------
P
E
L
-
E
A
----
T
F
L
--
K
F
T
------------
A
---
K
Y
LA
S
V
-
R
H
T
R
T
L
-
E
N
I
S
H
---
S
--
Y
-
Q
F
Y
S
P
V
---
V
-
R
L
F
K
R
W
L
D
T
---
H
L
L
-----
L
G
-------
H
-------
I
T
D
E
--
L
A
E
L
--------
I
A
I
K
P
F
V
D
P
AP
Y
F
I
----
P
GS
L
E
N
G
F
L
K
V
L
--
K
------------
F
-------
I
S
Q
----------
W
N
---
W
----
K
D
D
--
P
L
I
---
L
D
-------
L
---
V
---
K
-----
P
--
E
E
R
L
T
L
A
Q
Y
K
G
I
Q
M
N
F
T
N
L
R
N
SDPNGTHLQFFV
A
S
K
N
D
P
S
G
I
L
Y
S
SGIP
L
P
I
A
T
R
L
T
-
A
L
A
-
K
V
A
V
N
L
L
Q
T
H
G
L
N
Q
Q
--
T
I
N
L
L
F
T
P
-
G
L
K
D
Y
D
F
V
V
D
L
R
T
PIGLKSSCGILS
A
P
S
N
F
P
E
N
L
N
D
L
S
E
K
M
D
P
T
Y
Q
L
V
--------
K
Y
L
N
L
K
-
Y
K
N
S
L
I
-
L
S
S
R
K
YIGVNGGEKGD
K
N
V
I
T
G
L
I
KP
L
-----
F
K
-
G
A
-
H
K
F
R
V
------------------
N
L
D
C
N
V
-------
K
P
---
V
D
D
E
N
V
I
---
L
N
K
E
A
-
I
F
------
H
E
I
A
A
F
G
N
D
M
V
I
N
F
E
T
D------------------------------
19
PsiBlast_PDB
70.38
30%
-53
- C8 -
1GK1
1
?
B:
[1-355]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
S
W
A
V
A
P
G
K
T
A
----
N
G
N
A
L
L
L
Q
N
P
H
L
S
W
T
T
D
Y
-
F
T
-
Y
Y
E
A
H
L
V
T
P
D
F
E
I
Y
G
A
T
Q
I
G
L
P
V
I
-
R
-
F
A
F
N
Q
R
M
-----------------
G
I
T
N
T
V
-
N
G
M
V
G
A
T
N
Y
R
-------------
L
T
L
Q
-----------------------------------
D
-
G
G
Y
L
Y
D
G
Q
V
R
P
F
E
R
R
Q
A
S
Y
R
--
L
R
Q
A
D
G
----
T
-
T
V
D
K
P
L
E
I
------------
R
S
S
V
H
G
P
V
F
E
--------------------
R
A
D
G
T
A
V
A
--
V
R
V
A
G
L
D
R
-----------
P
G
M
L
E
Q
Y
F
D
M
-
I
---
T
A
D
S
F
D
D
Y
E
A
A
L
A
-
R
M
-
Q
V
P
T
F
N
I
V
Y
A
D
R
E
G
T
I
N
Y
S
F
-
N
G
V
A
P
K
R
A
E
G
D
I
-----
A
F
W
Q
G
L
V
P
G
D
--------
S
S
R
Y
L
W
T
E
--------
T
H
P
L
D
D
L
P
-----
R
V
T
N
P
P
G
G
F
V
Q
N
S
N
---
D
------------
P
P
----------------
W
T
P
T
W
-
P
V
T
Y
T
P
K
------
D
F
----
P
S
Y
L
A
P
-
Q
T
P
-
H
S
L
R
A
Q
------
Q
S
V
-
R
L
M
S
--
E
N
D
--
D
L
T
L
E
R
F
M
A
L
Q
L
SHR
A
---
V
M
--
A
D
R
T
L
P
D
L
I
P
A
A
L
I
D
---
P
--
D
-
P
E
V
Q
A
A
---
A
-
R
L
L
A
A
W
--
D
---
R
E
F
-----
T
S
-------
D
-------
S
R
A
A
--
L
L
F
E
--------
E
W
A
R
L
F
A
G
Q
--
N
F
A
----
G
---
Q
A
G
F
A
T
P
W
--
S
------------
L
-------
D
K
P
----------
V
S
---
T
----
P
Y
G
V
-
R
D
P
---
K
A
A
V
D
Q
L
R
T
A
---
I
---
A
-----
N
--
T
K
R
K
Y
G
A
I
D
R
P
F
G
D
A
S
R
M
I
L
N
------------
D
V
N
V
P
G
A
A
G
Y
G
N
-----------
L
-
G
S
F
-
R
V
F
T
W
S
D
P
D
E
N
G
V
R
T
--
P
V
H
G
--
E
T
-
W
V
A
M
I
E
F
S
T
P
V
--------------
R
A
Y
G
L
M
S
Y
G
N
S
R
Q
P
G
T
T
H
Y
S
D
Q
I
--------
E
R
V
S
R
A
-
D
F
R
E
L
L
-
L
R
R
E
Q
---------------
V
E
A
---
A
-----
V
Q
-
E
R
-
T
P
F
N
F
K
-----------
P
----------------------------------------------------------------------------------------------
17
PsiBlast_PDB
70.27
30%
-57
- C8 -
3JTQ
2
?
B:
[1-355]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
S
W
A
V
A
P
G
K
T
A
----
N
G
N
A
L
L
L
Q
N
P
H
L
S
W
T
T
D
Y
-
F
T
-
Y
Y
E
A
H
L
V
T
P
D
F
E
I
Y
G
A
T
Q
I
G
L
P
V
I
-
R
-
F
A
F
N
Q
R
M
-----------------
G
I
T
N
T
V
-
N
G
M
V
G
A
T
N
Y
R
-------------
L
T
L
Q
-----------------------------------
D
-
G
G
Y
L
Y
D
G
Q
V
R
P
F
E
R
R
Q
A
S
Y
R
--
L
R
Q
A
D
G
----
T
-
T
V
D
K
P
L
E
I
------------
R
S
S
V
H
G
P
V
F
E
--------------------
R
A
D
G
T
A
V
A
--
V
R
V
A
G
L
D
R
-----------
P
G
M
L
E
Q
Y
F
D
M
-
I
---
T
A
D
S
F
D
D
Y
E
A
A
L
A
-
R
M
-
Q
V
P
T
F
N
I
V
Y
A
D
R
E
G
T
I
N
Y
S
F
-
N
G
V
A
P
K
R
A
E
G
D
I
-----
A
F
W
Q
G
N
V
P
G
D
--------
S
S
R
Y
L
W
T
E
--------
T
H
P
L
D
D
L
P
-----
R
V
T
N
P
P
G
G
F
V
Q
N
S
N
---
D
------------
P
P
----------------
W
T
P
T
W
-
P
V
T
Y
T
P
K
------
D
F
----
P
S
Y
L
A
P
-
Q
T
P
-
H
S
L
R
A
Q
------
Q
S
V
-
R
L
M
S
--
E
N
D
--
D
L
T
L
E
R
F
M
A
L
Q
L
SHR
A
---
V
M
--
A
D
R
T
L
P
D
L
I
P
A
A
L
I
D
---
P
--
D
-
P
E
V
Q
A
A
---
A
-
R
L
L
A
A
W
--
D
---
R
E
F
-----
T
S
-------
D
-------
S
R
A
A
--
L
L
F
E
--------
E
W
A
R
L
F
A
G
Q
--
N
F
A
----
G
---
Q
A
G
F
A
T
P
W
--
S
------------
L
-------
D
K
P
----------
V
S
---
T
----
P
Y
G
V
-
R
D
P
---
K
A
A
V
D
Q
L
R
T
A
---
I
---
A
-----
N
--
T
K
R
K
Y
G
A
I
D
R
P
F
G
D
A
S
R
M
I
L
N
------------
D
V
N
V
P
G
A
A
G
Y
G
N
-----------
L
-
G
S
F
-
R
V
F
T
W
S
D
P
D
E
N
G
V
R
T
--
P
V
H
G
--
E
T
-
W
V
A
M
I
E
F
S
T
P
V
--------------
R
A
Y
G
L
M
S
Y
G
N
S
R
Q
P
G
T
T
H
Y
S
D
Q
I
--------
E
R
V
S
R
A
-
D
F
R
E
L
L
-
L
R
R
E
Q
---------------
V
E
A
---
A
-----
V
Q
-
E
R
-
T
P
F
N
F
K
-----------
P
----------------------------------------------------------------------------------------------
20
PsiBlast_PDB
70.11
30%
-55
- C8 -
2AE4
2
?
B:
[1-355]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
S
W
A
V
A
P
G
K
T
A
----
N
G
N
A
L
L
L
Q
N
P
H
L
S
W
T
T
D
Y
-
F
T
-
Y
Y
E
A
H
L
V
T
P
D
F
E
I
Y
G
A
T
Q
I
G
L
P
V
I
-
R
-
F
A
F
N
Q
R
M
-----------------
G
I
T
N
T
V
-
N
G
M
V
G
A
T
N
Y
R
-------------
L
T
L
Q
-----------------------------------
D
-
G
G
Y
L
Y
D
G
Q
V
R
P
F
E
R
R
Q
A
S
Y
R
--
L
R
Q
A
D
G
----
T
-
T
V
D
K
P
L
E
I
------------
R
S
S
V
H
G
P
V
F
E
--------------------
R
A
D
G
T
A
V
A
--
V
R
V
A
G
L
D
R
-----------
P
G
M
L
E
Q
Y
F
D
M
-
I
---
T
A
D
S
F
D
D
Y
E
A
A
L
A
-
R
M
-
Q
V
P
T
F
N
I
V
Y
A
D
R
E
G
T
I
N
Y
S
F
-
N
G
V
A
P
K
R
A
E
G
D
I
-----
A
F
W
Q
G
L
V
P
G
D
--------
S
S
R
Y
L
W
T
E
--------
T
H
P
L
D
D
L
P
-----
R
V
T
N
P
P
G
G
F
V
Q
N
S
N
---
D
------------
P
P
----------------
W
T
P
T
W
-
P
V
T
Y
T
P
K
------
D
F
----
P
S
Y
L
A
P
-
Q
T
P
-
H
S
L
R
A
Q
------
Q
S
V
-
R
L
M
S
--
E
N
D
--
D
L
T
L
E
R
F
M
A
L
Q
L
SHR
A
---
V
M
--
A
D
R
T
L
P
D
L
I
P
A
A
L
I
D
---
P
--
D
-
P
E
V
Q
A
A
---
A
-
R
L
L
A
A
W
--
D
---
R
E
F
-----
T
S
-------
D
-------
S
R
A
A
--
L
L
F
E
--------
E
W
A
R
L
F
A
G
Q
--
N
F
A
----
G
---
Q
A
G
F
A
T
P
W
--
S
------------
L
-------
D
K
P
----------
V
S
---
T
----
P
Y
G
V
-
R
D
P
---
K
A
A
V
D
Q
L
R
T
A
---
I
---
A
-----
N
--
T
K
R
K
Y
G
A
I
D
R
P
F
G
D
A
S
R
M
I
L
N
------------
D
V
N
V
P
G
A
A
G
Y
G
N
-----------
L
-
G
S
F
-
R
V
F
T
W
S
D
P
D
E
N
G
V
R
T
--
P
V
H
G
--
E
T
-
W
V
A
M
I
E
F
S
T
P
V
--------------
R
A
Y
G
L
M
S
Y
G
N
S
R
Q
P
G
T
T
H
Y
S
D
Q
I
--------
E
R
V
S
R
A
-
D
F
R
E
L
L
-
L
R
R
E
Q
---------------
V
E
A
---
A
-----
V
Q
-
E
R
-
T
P
F
N
F
K
-----------
P
----------------------------------------------------------------------------------------------
5
PsiBlast_PDB
69.28
26%
-50
- C8 -
3ML0
1
?
B:
[1-359]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
L
W
S
T
R
P
E
R
V
Q
----
E
G
S
T
V
L
I
N
G
P
Q
F
G
-
W
Y
N
P
-
A
Y
-
T
Y
G
I
G
L
H
G
A
G
F
D
V
V
G
N
T
P
F
A
Y
P
I
V
-
L
-
F
G
T
N
S
E
I
-
A
W
--------------
G
A
T
A
G
P
-
Q
D
V
V
D
I
Y
Q
E
K
-------------
L
N
P
S
-----------------------------------
R
A
D
Q
Y
W
F
N
N
A
W
R
T
M
E
Q
R
K
E
R
I
Q
--
V
R
--
G
Q
----
A
-
D
R
E
--
M
T
I
------------
W
R
T
V
H
G
P
V
M
Q
F
D
Y
D
---------
Q
G
A
A
Y
S
K
K
R
---------
S
W
D
G
Y
E
V
---
Q
S
----
L
-
L
A
W
L
N
----
V
-
A
---
K
A
R
N
W
T
E
F
L
D
Q
A
S
-
K
M
-
A
I
S
I
-
N
W
Y
Y
A
D
K
H
G
N
I
G
Y
V
S
-
P
A
F
L
P
Q
R
P
A
D
Q
D
-----
I
R
--
V
P
A
K
G
---------
D
G
S
M
E
W
L
G
--------
I
K
S
F
D
A
I
P
-----
K
A
Y
N
P
P
Q
G
Y
L
V
N
W
N
---
N
---------
K
P
A
P
D
K
---------
T
N
T
D
---
T
Y
Y
W
-
T
Y
G
---
D
------
R
M
----
N
E
L
V
S
Q
-
Y
Q
Q
-
K
D
L
--
F
------
S
V
Q
-
E
I
W
E
F
N
Q
K
A
--
S
Y
S
------------
D
---
V
N
--
W
R
-
Y
F
R
P
H
L
-
E
K
L
A
Q
QLP
A
--
D
-
D
S
S
K
A
A
---
L
-
T
M
L
L
A
W
--
D
G
M
E
Q
D
Q
-----
G
G
-------
Q
-------
N
A
G
P
A
R
V
L
F
K
--------
T
W
L
E
E
M
Y
K
Q
--
V
L
M
----
P
---
V
V
P
E
S
H
R
A
--
M
------------
Y
-------
S
Q
T
----------
G
F
---
A
----
T
Q
Q
G
-
P
N
P
---
G
S
I
N
L
S
M
G
T
K
---
V
---
L
-----
L
--
R
A
L
V
L
E
A
H
P
D
P
K
R
V
N
V
F
G
E
R
S
------------
S
Q
E
I
M
H
T
A
L
Q
N
A
-----------
Q
-
A
R
L
-
S
Q
E
Q
G
A
Q
M
A
R
W
T
M
P
T
--
S
V
H
R
--
F
S
-
D
K
N
F
T
G
T
P
Q
T
M
--------------
P
G
N
T
F
A
F
T
G
Y
Q
N
R
G
T
E
N
N
R
V
V
F
D
--------
A
K
G
V
E
F
-
C
D
A
M
P
P
-
G
Q
S
G
F
---------------
T
D
R
---
N
-----
G
V
-
R
S
-
P
H
Y
E
D
Q
-----------
L
-----
K
L
Y
E
N
F
-------
E
C
---
K
T
M
D
V
T
H
---
A
D
I
R
R
-
N
A
------
Q
S
S
T
M
L
L
I
Q
P
Q
P
-----------------------------------
4
PsiBlast_PDB
68.80
26%
-45
- C8 -
3K3W
1
?
B:
[1-359]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
L
W
S
T
R
P
E
R
V
Q
----
E
G
S
T
V
L
I
N
G
P
Q
F
G
-
W
Y
N
P
-
A
Y
-
T
Y
G
I
G
L
H
G
A
G
F
D
V
V
G
N
T
P
F
A
Y
P
I
V
-
L
-
F
G
T
N
S
E
I
-
A
W
--------------
G
A
T
A
G
P
-
Q
D
V
V
D
I
Y
Q
E
K
-------------
L
N
P
S
-----------------------------------
R
A
D
Q
Y
W
F
N
N
A
W
R
T
M
E
Q
R
K
E
R
I
Q
--
V
R
--
G
Q
----
A
-
D
R
E
--
M
T
I
------------
W
R
T
V
H
G
P
V
M
Q
F
D
Y
D
---------
Q
G
A
A
Y
S
K
K
R
---------
S
W
D
G
Y
E
V
---
Q
S
----
L
-
L
A
W
L
N
----
V
-
A
---
K
A
R
N
W
T
E
F
L
D
Q
A
S
-
K
M
-
A
I
S
I
-
N
W
Y
Y
A
D
K
H
G
N
I
G
Y
V
S
-
P
A
F
L
P
Q
R
P
A
D
Q
D
-----
I
R
--
V
P
A
K
G
---------
D
G
S
M
E
W
L
G
--------
I
K
S
F
D
A
I
P
-----
K
A
Y
N
P
P
Q
G
Y
L
V
N
W
N
---
N
---------
K
P
A
P
D
K
---------
T
N
T
D
---
T
Y
Y
W
-
T
Y
G
---
D
------
R
M
----
N
E
L
V
S
Q
-
Y
Q
Q
-
K
D
L
--
F
------
S
V
Q
-
E
I
W
E
FN
Q
K
A
--
S
Y
S
------------
D
---
V
N
--
W
R
-
Y
F
R
P
H
L
-
E
K
L
A
Q
Q
LP
A
--
D
-
D
S
S
K
A
A
---
L
-
T
M
L
L
A
W
--
D
GME
Q
D
Q
-----
G
G
-------
Q
-------
N
A
G
P
A
R
V
L
F
K
--------
T
W
L
E
E
M
Y
K
Q
--
V
L
M
----
P
---
V
V
P
E
S
H
R
A
--
M
------------
Y
-------
S
Q
T
----------
G
F
---
A
----
T
Q
Q
G
-
P
N
P
---
G
S
I
N
L
S
M
G
T
K
---
V
---
L
-----
L
--
R
A
L
V
L
E
A
H
P
D
P
K
R
V
N
V
F
G
E
R
S
------------
S
Q
E
I
M
H
T
A
L
Q
N
A
-----------
Q
-
A
R
L
-
S
Q
E
Q
G
A
Q
M
A
R
W
T
M
P
T
--
S
V
H
R
--
F
S
-
D
K
N
F
T
G
T
P
Q
T
M
--------------
P
G
N
T
F
A
F
T
G
Y
Q
N
R
G
T
E
N
N
R
V
V
F
D
--------
A
K
G
V
E
F
-
C
D
A
M
P
P
-
G
Q
S
G
F
---------------
T
D
R
---
N
-----
G
V
-
R
S
-
P
H
Y
E
D
Q
-----------
L
-----
K
L
Y
E
N
F
-------
E
C
---
K
T
M
D
V
T
H
---
A
D
I
R
R
-
N
A
------
Q
S
S
T
M
L
L
I
Q
P
Q
P
-----------------------------------
92
Fugue
68.05
19%
-54
- C1 -
4LXR
11
TOLL_DROME
A:
[1-773]
----------------------------------------------------------------------------------------
S
F
G
R
D
A
C
S
-----
E
M
S
I
D
G
L
C
Q
C
A
P
I
M
S
E
Y
---------
E
I
I
C
P
-----------------------
A
N
A
E
N
P
T
F
R
L
T
I
Q
P
---
K
D
Y
V
Q
I
M
C
N
-
L
T
D
---------------
T
T
D
Y
Q
Q
L
P
K
K
L
R
I
G
E
V
D
R
V
Q
M
R
R
C
M
LPGHT
P
I
A
S
I
L
D
Y
L
G
I
V
S
-----------
P
T
T
L
I
F
E
--
S
-
D
N
L
G
M
N
I
T
R
Q
H
L
D
R
L
H
G
L
K
R
F
R
F
T
T
------
R
R
L
T
H
I
P
A
N
L
L
T
D
M
--------
R
N
L
S
H
L
E
L
----------------
R
A
N
I
E
------
E
M
P
S
------
H
L
FD
D
L
E
N
L
E
S
I
E
F
G
S
N
K
L
R
Q
M
P
--
R
G
I
F
------
G
K
M
P
K
L
K
Q
-
L
N
L
W
S
N
Q
L
H
N
L
T
K
H
D
F
E
G
A
T
-------
S
---
V
L
G
I
D
I
H
D
----
N
G
I
E
Q
L
P
H
D
V
F
A
H
-
L
T
N
------------
V
T
D
I
N
L
S
A
N
L
F
R
S
L
P
Q
G
-
L
-
F
D
H
N
K
---------------------------
H
L
N
E
V
R
L
M
---------------
N
N
R
-----------------------------------
V
P
L
A
T
L
-
P
S
R
L
F
A
N
Q
P
E
L
Q
I
L
R
--
L
R
---
A
----
E
-
L
Q
S
--
L
P
G
------------
D
L
F
E
H
S
T
Q
I
T
N
I
S
L
GDNLLKTL-
P
A
T
L
L
E
H
Q
V
N
L
L
S
L
D
--
L
S
N
N
R
L
T
H
L
P
D
S
L
----
F
-
A
H
T
T
N
----
L
-
T
---
D
L
R
L
E
D
N
L
L
T
-------
G
I
S
G
D
--
I
F
S
N
L
-
G
N
L
V
T
L
V
-
M
S
R
N
R
L
R
T
I
D
S
-------
R
A
F
V
S
T
N
G
L
--------
R
H
L
H
-----------------
L
D
H
-----
N
D
I
D
L
Q
Q
P
L
L
D
I
M
L
---
Q
---------
T
--
Q
I
N
---------
S
P
F
G
--
Y
M
H
G
L
L
T
L
N
L
R
N
N
------
S
I
IFVY
N
D
W
K
N
T
-
M
L
Q
L
R
E
L
--
D
LSYNNI
S
S
L
-
G
Y
----
E
D
L
--
A
F
L
------------
S
QNR
L
H
--
V
N
-
M
T
H
N
K
I
-
R
R
I
A
L
---
P
--
E
-
D
V
N
N
N
L
---
V
-
H
V
D
L
N
D
--
N
-------------------------------
P
--
L
V
C
D
--------
C
T
I
L
W
F
I
Q
L
--
V
--------------------
R
------------
G
-------
V
H
K
----------
P
Q
---
Y
----
S
R
Q
F
-
K
L
R
---
T
D
-----
R
L
V
---
C
---
S
-----
Q
--
P
N
V
L
E
G
T
P
V
R
Q
I
E
P
Q
T
L
I
C
P
L
------------
D
F
S
K
C
P
R
G
C
N
C
H
-----------
V
-
R
T
Y
-
D
K
A
L
V
I
N
C
H
S
G
N
L
T
H
--
V
P
R
L
--
P
N
L
H
K
N
M
Q
L
M
E
L
H
L
--------------
E
N
N
T
L
L
R
L
P
S
A
N
T
P
G
Y
E
S
V
T
S
L
H
LAGNNLTS
I
D
V
D
Q
L
-
P
T
N
L
T
H
-
L
D
I
S
W
---------------
N
H
L
---
Q
-----
M
L
-
N
A
-
T
V
L
G
F
L
NW
R
S
V
K
L
S
GNP
W
MCDCT
A
K
P
L
L
L
-------
F
T
---
Q
D
N
F
E
R
I
---
G
D
R
N
E
-
M
M
C
V
NAPT
R
M
V
E
L
S
T
N
D
I
C
P
-----------------------------------
73
HHSearch
67.09
24%
8
- C6 -
1FM2
-
?
B:
[170-686]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
S
W
A
V
A
P
G
K
T
A
----
N
G
N
A
L
L
L
Q
N
P
H
L
S
-
W
T
T
D
Y
F
T
-
Y
Y
E
A
H
L
V
T
P
D
F
E
I
Y
G
A
T
Q
I
G
L
P
V
I
-
R
-
F
A
F
N
Q
R
M
-
G
I
--------------
T
N
T
V
N
G
-
M
V
G
A
T
N
Y
R
L
T
-------------
L
Q
-------------------------------------
D
-
G
G
Y
L
Y
D
G
Q
V
R
P
F
E
R
R
Q
A
S
Y
R
--
L
R
--
Q
A
DG
S
-
T
V
D
K
P
--
L
E
I
------------
R
S
S
V
H
G
P
V
F
E
R
A
--------------------
D
G
T
A
V
A
--
V
R
V
A
G
L
D
R
--
P
G
M
----
L
-
E
Q
Y
F
D
----
M
-
I
---
T
A
H
S
F
D
D
Y
E
A
A
M
A
-
R
M
-
Q
V
P
T
F
N
I
V
Y
A
D
R
E
G
T
I
N
Y
S
F
-
N
G
V
A
P
K
R
A
E
G
D
I
-----
A
F
W
Q
G
N
V
P
G
D
--------
S
S
R
Y
L
W
T
E
--------
T
H
P
L
D
D
L
P
-----
R
V
T
N
P
P
G
G
F
V
Q
N
S
N
---
D
---------
P
P
W
T
P
T
WPVTYCPAN
H
P
S
Y
--
L
A
P
Q
T
-
P
H
S
L
R
A
Q
------
Q
S
----
V
R
L
M
S
E
-
N
D
D
-
L
T
L
--
E
------
R
F
M
-
A
L
----
Q
F
S
--
H
R
A
------------
V
---
M
A
--
D
R
-
T
L
P
D
L
I
-
P
A
A
L
I
---
D
--
P
D
P
E
V
Q
A
A
---
A
-
R
L
L
A
A
W
--
D
---
R
D
F
-----
T
S
-------
D
-------
S
R
A
A
--
L
L
F
E
--------
E
W
A
R
L
F
A
G
Q
--
N
F
A
----
G
---
Q
A
A
F
A
-----
T
------------
P
-------
W
S
-----------------------
L
D
-
K
P
----
V
-----
S
T
P
Y
---
G
---
V
---------
R
D
-
P
K
A
A
V
D
Q
L
R
T
A
I
A
N
T
K
R
------------
K
Y
G
--
A
I
D
R
P
F
G
-----------
D
-
A
S
R
-
M
I
L
N
D
-------------
V
N
V
--
P
G
A
A
G
Y
G
N
L
G
S
F
R
V
--------------
F
T
W
S
D
P
D
E
N
G
I
R
T
P
V
H
G
E
T
W
V
A
M
--------
I
E
F
S
T
P
-
V
R
A
Y
G
L
-
M
S
Y
G
N
---------------
S
R
Q
---
P
-----
G
T
T
H
Y
-
S
D
Q
I
E
R
-----------
V
-----
S
R
A
D
F
R
-------
E
L
---
L
L
R
R
E
Q
V
---
E
A
A
V
Q
-
E
R
------
T
P
F
N
F
------------------------------------------
85
Fugue
64.91
23%
3
- C6 -
1FM2
-
?
B:
[170-689]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
S
W
A
V
A
P
G
K
T
A
----
N
G
N
A
L
L
L
Q
N
P
H
L
S
-
W
T
T
D
-
Y
F
T
Y
Y
E
A
H
L
V
T
P
D
F
E
I
Y
G
A
T
Q
I
G
L
P
V
I
-
R
-
F
A
F
N
Q
R
-
M
G
I
--------------
T
N
T
V
N
G
M
V
G
A
T
N
Y
R
L
T
L
-------------
Q
---------------------------------------
D
G
G
Y
L
Y
D
G
Q
V
R
P
F
E
R
R
Q
A
S
Y
R
--
L
R
--
Q
A
DG
S
T
V
-
D
K
P
--
L
E
I
------------
R
S
S
V
H
G
P
V
F
E
--------------------
R
A
D
G
T
A
V
A
--
V
R
V
A
G
L
D
R
-
P
G
-------
M
L
E
Q
Y
F
----
D
M
I
---
T
A
H
S
F
D
D
Y
E
A
A
--
M
A
R
M
Q
V
P
T
F
N
I
V
Y
A
D
R
E
G
T
I
N
Y
S
F
-
N
G
V
A
P
K
R
A
E
G
D
I
-----
A
F
W
Q
G
N
V
P
G
D
--------
S
S
R
Y
L
W
T
E
--------
T
H
P
L
D
D
L
P
-----
R
V
T
N
P
P
G
G
F
V
Q
N
S
N
---
D
---------
P
P
W
T
P
T
---------
W
P
V
T
--
Y
C
P
A
N
-
H
P
S
Y
L
A
P
QTPHS
L
R
A
----
Q
Q
S
V
R
L
M
S
E
N
-
D
D
L
--
T
L
-----
E
R
F
M
A
L
----
Q
F
S
--
H
R
A
------------
V
M
--
A
D
--
R
T
-
L
P
D
L
I
P
-
A
A
L
I
D
---
P
--
D
-
P
E
V
Q
A
A
---
A
-
R
L
L
A
A
W
--
D
---
R
D
F
-----
T
S
-------
D
-------
S
R
A
A
--
L
L
F
E
--------
E
W
A
R
L
F
A
G
Q
--
N
F
A
----
G
---
Q
---
A
A
F
A
--
T
------------
P
-------
W
S
L
----------
D
K
---
P
----
V
S
T
P
-
Y
G
V
---
R
D
----------------------------
P
K
A
A
V
D
Q
L
R
T
A
I
A
N
T
K
R
------------
K
Y
G
--
A
I
D
R
P
F
G
-----------
D
-
A
S
R
M
I
L
N
D
V
N
V
P
G
A
A
G
Y
G
N
--
L
G
S
F
--------------
R
V
--------------
F
T
W
S
D
P
D
E
N
G
I
R
T
P
V
H
G
E
T
W
-
V
A
M
-------
I
E
F
S
T
P
-
V
R
A
Y
G
L
M
S
Y
G
N
S
---------------
R
Q
P
---
G
-----
T
T
-
H
Y
-
S
D
Q
I
E
R
-----------
V
-----
S
R
A
D
F
R
-------
E
L
LLR
R
E
Q
V
E
A
A
---
V
Q
E
R
T
-
P
F
------
N
F
---------------------------------------------
29
PsiBlast_CBE
62.33
31%
-52
- C8 -
1K5Q
2
?
B:
[1-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
M
W
V
I
G
K
S
K
A
Q
----
D
A
K
A
I
M
V
N
G
P
Q
A
G
-
W
Y
A
P
-
A
Y
-
T
Y
G
I
G
L
H
G
A
G
Y
D
V
T
G
N
T
P
F
A
Y
P
G
L
-
V
-
F
G
H
N
G
V
I
-
S
W
--------------
G
S
T
A
G
F
-
G
D
D
V
D
I
F
A
E
R
-------------
L
S
A
E
-----------------------------------
K
P
G
Y
Y
L
H
N
G
K
W
V
K
M
L
S
R
E
E
T
I
T
--
V
K
--
N
G
----
Q
-
A
E
T
--
F
T
V
------------
W
R
T
V
H
G
N
I
L
----------------
Q
T
D
Q
T
T
Q
T
A
Y
A
K
S
--
R
A
W
D
G
------
K
E
----
L
-
A
S
L
L
A
----
W
-
T
H
Q
M
K
A
K
N
W
Q
E
W
T
Q
Q
A
A
-
K
Q
-
A
L
T
I
-
N
W
Y
Y
A
D
V
N
G
N
I
G
Y
V
H
-
T
G
A
Y
P
D
R
Q
S
G
H
D
-----
P
R
--
L
P
V
P
G
---------
T
G
K
W
D
W
K
G
--------
L
L
P
F
E
M
N
P
-----
K
V
Y
N
P
Q
S
G
Y
I
A
N
W
N
NSP
Q
---------
K
D
Y
P
A
S
---------
D
L
F
A
--
F
L
W
G
G
-
A
D
R
V
T
E
I
------
D
R
----
L
L
E
Q
K
P
-
R
L
T
-
A
D
Q
--
A
------
W
D
V
-
I
R
----
Q
T
S
--
R
Q
D
------------
L
---
N
L
--
R
L
-
F
L
P
T
L
Q
-
A
A
T
S
G
---
L
--
T
-
Q
S
D
P
R
R
---
Q
-
L
V
E
T
L
T
--
R
---
W
D
G
-----
I
N
-------
L
-------
L
N
D
D
--
G
K
T
W
--------
Q
Q
P
G
S
A
I
L
N
--
V
W
L
----
T
---
S
M
L
K
R
T
V
V
--
A
------------
A
-------
V
P
M
----------
P
F
---
D
----
K
W
Y
S
-
A
S
G
---
Y
E
T
T
Q
D
G
P
T
G
---
S
---
L
-----
N
--
I
S
V
G
A
K
I
L
Y
E
A
V
Q
G
D
K
S
P
I
P
Q
------------
A
V
D
L
F
A
G
K
P
Q
Q
E
-----------
V
-
V
L
A
-
A
L
E
D
T
W
E
T
L
S
K
R
Y
G
N
--
N
V
S
N
--
W
K
-
T
P
A
M
A
L
T
F
R
A
N
--------------
N
F
F
G
V
P
Q
A
A
A
E
E
T
R
H
Q
A
E
Y
Q
N
R
G
--------
T
E
N
D
M
I
-
V
F
S
P
T
T
-
S
D
R
P
V
---------------
L
A
W
---
D
-----
V
V
-
A
P
-
G
Q
S
G
F
I
-----------
A
-----
P
D
G
T
V
D
-------
K
H
---
Y
E
D
Q
L
K
M
---
Y
E
N
F
G
-
R
K
------
S
L
W
L
T
K
Q
D
V
E
A
H
-----------------------------------
9
PsiBlast_PDB
62.19
31%
-48
- C8 -
1E3A
4
?
B:
[2-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
-------
S
N
M
W
V
I
G
K
S
K
A
Q
----
D
A
K
A
I
M
V
N
G
P
Q
F
G
-
W
Y
A
P
-
A
Y
-
T
Y
G
I
G
L
H
G
A
G
Y
D
V
T
G
N
T
P
F
A
Y
P
G
L
-
V
-
F
G
H
N
G
V
I
-
S
W
--------------
G
S
T
A
G
F
-
G
D
D
V
D
I
F
A
E
R
-------------
L
S
A
E
-----------------------------------
K
P
G
Y
Y
L
H
N
G
K
W
V
K
M
L
S
R
E
E
T
I
T
--
V
K
--
N
G
----
Q
-
A
E
T
--
F
T
V
------------
W
R
T
V
H
G
N
I
L
----------------
Q
T
D
Q
T
T
Q
T
A
Y
A
K
S
--
R
A
W
D
G
------
K
E
----
V
-
A
S
L
L
A
----
W
-
T
H
Q
M
K
A
K
N
W
Q
E
W
T
Q
Q
A
A
-
K
Q
-
A
L
T
I
-
N
W
Y
Y
A
D
V
N
G
N
I
G
Y
V
H
-
T
G
A
Y
P
D
R
Q
S
G
H
D
-----
P
R
--
L
P
V
P
G
---------
T
G
K
W
D
W
K
G
--------
L
L
P
F
E
M
N
P
-----
K
V
Y
N
P
Q
S
G
Y
I
A
N
W
N
NSP
Q
---------
K
D
Y
P
A
S
---------
D
L
F
A
--
F
L
W
G
G
-
A
D
R
V
T
E
I
------
D
R
----
L
L
E
Q
K
P
-
R
L
T
-
A
D
Q
--
A
------
W
D
V
-
I
R
----
Q
T
S
--
R
Q
D
------------
L
---
N
L
--
R
L
-
F
L
P
T
L
Q
-
A
A
T
S
G
---
L
--
T
-
Q
S
D
P
R
R
---
Q
-
L
V
E
T
L
T
--
R
---
W
D
G
-----
I
N
-------
L
-------
L
N
D
D
--
G
K
T
W
--------
Q
Q
P
G
S
A
I
L
N
--
V
W
L
----
T
---
S
M
L
K
R
T
V
V
--
A
------------
A
-------
V
P
M
----------
P
F
---
D
----
K
W
Y
S
-
A
S
G
---
Y
E
T
T
Q
D
G
P
T
G
---
S
---
L
-----
N
--
I
S
V
G
A
K
I
L
Y
E
A
V
Q
G
D
K
S
P
I
P
Q
------------
A
V
D
L
F
A
G
K
P
Q
Q
E
-----------
V
-
V
L
A
-
A
L
E
D
T
W
E
T
L
S
K
R
Y
G
N
--
N
V
S
N
--
W
K
-
T
P
A
M
A
L
T
F
R
A
N
--------------
N
F
F
G
V
P
Q
A
A
A
E
E
T
R
H
Q
A
E
Y
Q
N
R
G
--------
T
E
N
D
M
I
-
V
F
S
P
T
T
-
S
D
R
P
V
---------------
L
A
W
---
D
-----
V
V
-
A
P
-
G
Q
S
G
F
I
-----------
A
-----
P
D
G
T
V
D
-------
K
H
---
Y
E
D
Q
L
K
M
---
Y
E
N
F
G
-
R
K
------
S
L
W
L
T
K
Q
D
V
E
A
H
-----------------------------------