@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2011: (2016-02-03 )
MNLPKKVRLVEVGPRDGLQNEKQPIEVADKIRLVDDLSAAGLDYIEVGSFVSPKWVPQMAGSAEVFAGIRQRPGVTYAALAPNLKGFEAALESGVKEVAVFAAASEAFSQRNINCSIKDSLERFVPVLEAARQHQVRVRGYISCVLGCPYDGDVDPRQVAWVARELQQMGCYEVSLGDTIGVGTAGATRRLIEAVASEVPRERLAGHFHDTYGQALANIYASLLEGIAVFDSSVAGLGGCPYAKGATGNVASEDVLYLLNGLEIHTGVDMHALVDAGQRICAVLGKSNGSRAAKALLAKA
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNLP
K
K
V
R
L
V
E
VGPRDGLQNEKQ
P
I
E
V
A
D
K
I
R
L
V
DD
L
S
AAGL
D
Y
I
EVGSFVSP
K
W
V
P
QMAG
S
A
E
V
F
A
G
I
R
QRPG
V
T
Y
A
ALAPN
L
K
G
F
E
A
A
L
E
S
G
V
K
E
V
A
V
F
A
A
A
S
E
A
F
SQRNINC
S
I
K
D
S
L
E
R
F
V
P
V
L
E
A
A
R
Q
H
Q
V
R
V
R
G
Y
I
S
C
V
LGCPYDGDV
D
P
R
Q
V
A
W
V
A
R
E
L
Q
QMG
C
Y
E
VSLG
D
T
IGVGT
A
G
A
T
R
R
L
I
E
A
V
A
S
EV
P
R
E
R
L
A
G
HF
H
D
T
Y
G
Q
A
L
A
N
I
Y
A
S
L
L
E
G
I
A
V
F
DSSVAGLGGCPYAKGATGNV
A
S
E
D
V
L
Y
L
LNG
L
E
IHTGV
D
M
H
A
L
V
D
A
G
Q
R
I
C
A
V
LGKSN
G
S
R
A
A
K
A
L
LAKA
34
HHSearch
99.68
100%
-106
- C3 -
2FTP
3
LIUE_PSEAE
A:
[3-302]
M
N
L
P
K
K
V
R
L
V
E
V
G
P
R
D
G
L
Q
N
E
K
Q
P
I
E
V
A
D
K
I
R
L
V
D
D
L
S
A
A
G
L
D
Y
I
E
V
G
S
F
V
S
P
K
W
V
P
Q
M
A
G
S
A
E
V
F
A
G
I
R
Q
R
P
G
V
T
Y
A
A
L
A
P
N
L
K
G
F
E
A
A
L
E
S
G
V
K
E
V
A
V
F
A
A
A
S
E
A
F
S
Q
R
N
I
N
C
S
I
K
D
S
L
E
R
F
V
P
V
L
E
A
A
R
Q
H
Q
V
R
V
R
G
Y
I
S
C
V
L
G
C
P
Y
D
G
D
V
D
P
R
Q
V
A
W
V
A
R
E
L
Q
Q
M
G
C
Y
E
V
S
L
G
D
T
I
G
V
G
T
A
G
A
T
R
R
L
I
E
A
V
A
S
E
V
P
R
E
R
L
A
G
H
F
H
D
T
Y
G
Q
A
L
A
N
I
Y
A
S
L
L
E
G
I
A
V
F
D
S
S
V
A
G
L
G
G
C
P
Y
A
K
G
A
T
G
N
V
A
S
E
D
V
L
Y
L
L
N
G
L
E
I
H
T
G
V
D
M
H
A
L
V
D
A
G
Q
R
I
C
A
V
L
G
K
S
N
G
S
R
A
A
K
A
L
L
A
K
A
1
PsiBlast_PDB
99.68
100%
-106
- C3 -
2FTP
3
LIUE_PSEAE
A:
[3-302]
M
N
L
P
K
K
V
R
L
V
E
V
G
P
R
D
G
L
Q
N
E
K
Q
P
I
E
V
A
D
K
I
R
L
V
D
D
L
S
A
A
G
L
D
Y
I
E
V
G
S
F
V
S
P
K
W
V
P
Q
M
A
G
S
A
E
V
F
A
G
I
R
Q
R
P
G
V
T
Y
A
A
L
A
P
N
L
K
G
F
E
A
A
L
E
S
G
V
K
E
V
A
V
F
A
A
A
S
E
A
F
S
Q
R
N
I
N
C
S
I
K
D
S
L
E
R
F
V
P
V
L
E
A
A
R
Q
H
Q
V
R
V
R
G
Y
I
S
C
V
L
G
C
P
Y
D
G
D
V
D
P
R
Q
V
A
W
V
A
R
E
L
Q
Q
M
G
C
Y
E
V
S
L
G
D
T
I
G
V
G
T
A
G
A
T
R
R
L
I
E
A
V
A
S
E
V
P
R
E
R
L
A
G
H
F
H
D
T
Y
G
Q
A
L
A
N
I
Y
A
S
L
L
E
G
I
A
V
F
D
S
S
V
A
G
L
G
G
C
P
Y
A
K
G
A
T
G
N
V
A
S
E
D
V
L
Y
L
L
N
G
L
E
I
H
T
G
V
D
M
H
A
L
V
D
A
G
Q
R
I
C
A
V
L
G
K
S
N
G
S
R
A
A
K
A
L
L
A
K
A
27
PsiBlast_CBE
83.45
57%
-98
- C3 -
2CW6
1
HMGCL_HUMAN
E:
[1-294]
-
T
L
P
K
R
V
K
I
V
E
V
G
P
R
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
G
C
P
Y
A
Q
G
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
A
T
C
---
35
HHSearch
83.10
57%
-100
- C3 -
2CW6
2
HMGCL_HUMAN
A:
[2-295]
--
L
P
K
R
V
K
I
V
E
V
G
P
R
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
G
C
P
Y
A
Q
G
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
A
T
C
---
2
PsiBlast_PDB
82.87
57%
-100
- C3 -
2CW6
2
HMGCL_HUMAN
A:
[1-294]
-
T
L
P
K
R
V
K
I
V
E
V
G
P
R
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
G
C
P
Y
A
Q
G
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
A
T
C
---
30
PsiBlast_CBE
82.74
57%
-99
- C3 -
2CW6
1
HMGCL_HUMAN
B:
[1-294]
-
T
L
P
K
R
V
K
I
V
E
V
G
P
R
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
G
C
P
Y
A
Q
G
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
A
T
C
---
21
PsiBlast_CBE
82.52
57%
-97
- C3 -
3MP3
1
HMGCL_HUMAN
F:
[1-294]
-
T
L
P
K
R
V
K
I
V
E
V
G
P
R
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
G
C
P
Y
A
Q
G
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
A
T
C
---
28
PsiBlast_CBE
82.51
57%
-96
- C3 -
2CW6
1
HMGCL_HUMAN
D:
[1-294]
-
T
L
P
K
R
V
K
I
V
E
V
G
P
R
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
-------
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
-------
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
A
T
C
---
26
PsiBlast_CBE
82.17
57%
-98
- C3 -
2CW6
1
HMGCL_HUMAN
F:
[1-294]
-
T
L
P
K
R
V
K
I
V
E
V
G
P
R
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
--
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
------
G
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
A
T
C
---
4
PsiBlast_PDB
82.08
57%
-98
- C3 -
3MP4
-
HMGCL_HUMAN
A:
[28-321]
-
T
L
P
K
R
V
K
I
V
E
V
G
P
M
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
G
C
P
Y
A
Q
G
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
A
T
C
---
3
PsiBlast_PDB
81.89
57%
-97
- C3 -
3MP3
2
HMGCL_HUMAN
A:
[1-294]
-
T
L
P
K
R
V
K
I
V
E
V
G
P
R
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
G
C
P
Y
A
Q
G
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
A
T
C
---
25
PsiBlast_CBE
81.47
57%
-93
- C3 -
3MP3
2
HMGCL_HUMAN
B:
[1-294]
-
T
L
P
K
R
V
K
I
V
E
V
G
P
R
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
G
C
P
Y
A
Q
G
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
A
T
C
---
32
PsiBlast_CBE
81.42
57%
-93
- C3 -
3MP5
2
HMGCL_HUMAN
B:
[1-294]
-
T
L
P
K
R
V
K
I
V
E
V
G
P
M
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
G
C
P
Y
A
Q
G
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
A
T
C
---
5
PsiBlast_PDB
81.10
57%
-97
- C3 -
3MP5
-
HMGCL_HUMAN
A:
[1-294]
-
T
L
P
K
R
V
K
I
V
E
V
G
P
M
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
G
C
P
Y
A
Q
G
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
A
T
C
---
31
PsiBlast_CBE
81.05
57%
-95
- C3 -
3MP5
1
HMGCL_HUMAN
C:
[1-294]
-
T
L
P
K
R
V
K
I
V
E
V
G
P
M
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
--------
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
A
T
C
---
29
PsiBlast_CBE
81.05
57%
-98
- C3 -
2CW6
1
HMGCL_HUMAN
C:
[2-294]
--
L
P
K
R
V
K
I
V
E
V
G
P
R
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
G
C
P
Y
A
Q
G
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
A
T
----
23
PsiBlast_CBE
80.97
57%
-99
- C3 -
3MP3
1
HMGCL_HUMAN
D:
[1-294]
-
T
L
P
K
R
V
K
I
V
E
V
G
P
R
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
-------
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
A
T
C
---
22
PsiBlast_CBE
80.74
57%
-95
- C3 -
3MP3
1
HMGCL_HUMAN
E:
[1-294]
-
T
L
P
K
R
V
K
I
V
E
V
G
P
R
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
G
C
P
Y
A
Q
G
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
A
T
C
---
24
PsiBlast_CBE
80.25
57%
-98
- C3 -
3MP3
1
HMGCL_HUMAN
C:
[1-294]
-
T
L
P
K
R
V
K
I
V
E
V
G
P
R
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
G
C
P
Y
A
Q
G
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
A
T
C
---
36
HHSearch
77.77
46%
-95
- C3 -
1YDO
1
HMGCL_BACSU
A:
[1-295]
M
P
Y
P
K
K
V
T
I
K
E
V
G
P
R
D
G
L
Q
N
E
P
V
W
I
A
T
E
D
K
I
T
W
I
N
Q
L
S
R
T
G
L
S
Y
I
E
I
T
S
F
V
H
P
K
W
I
P
A
L
R
D
A
I
D
V
A
K
G
I
D
R
E
K
G
V
T
Y
A
A
L
V
P
N
Q
R
G
L
E
N
A
L
E
G
G
I
N
E
A
C
V
F
M
S
A
S
E
T
H
N
R
K
N
I
N
K
S
T
S
E
S
L
H
I
L
K
Q
V
N
N
D
A
Q
K
A
N
L
T
T
R
A
Y
L
S
T
V
F
G
C
P
Y
E
K
D
V
P
I
E
Q
V
I
R
L
S
E
A
L
F
E
F
G
I
S
E
L
S
L
G
D
T
I
G
A
A
N
P
A
Q
V
E
T
V
L
E
A
L
L
A
R
F
P
A
N
Q
I
A
L
H
F
H
D
T
R
G
T
A
L
A
N
M
V
T
A
L
Q
M
G
I
T
V
F
D
G
S
A
G
G
L
G
G
C
P
Y
A
P
G
S
S
G
N
A
A
T
E
D
I
V
Y
M
L
E
Q
M
D
I
K
T
N
V
K
L
E
K
L
L
S
A
A
K
W
I
E
E
K
M
G
K
P
L
P
S
R
N
L
Q
V
F
K
S
--