@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2049: (2016-02-03 )
MLVAIHGLIHRLGLYGEHLEGALVNDSEALYAHPATYYRREDLLPAFESNEALRERFFGGVKKPIFTSANAHNHLVGLAEVLAMYLLVWSPAPWRLVRLEPPPGLDARHAQRFAGERRHIEAFRDGLPRVARALAHISSLMIFDDHDITDDWNLSARWELTAYGHPFSRRIIGNALLAYLLCQGWGNDPQHCGEWLAPVAALMEGAAADGRLPCAEQDRLLDALLDFQHWHYRLPGSPTLIVLDTRTRRWRSERNLGRPSGLMDWEALSEFQQDLLGEKAAIIVSPAPMFGVKLIEGVQKLFSWIGQPLLVDAENWMAHRGAASVMMNIFRHSRTPGNYLILSGDVHYSFVYDIRIRHRERGPRLWQITSSGIKNEFPRRLLDWFDRLNRWLYAPWSPLNWLTQRRSLEIRPRVPQHSQAGERLWNSAGIGQVFIGEDGRPRAVLQVNADGSPATAFERHRDVEDERADQSPVAPGR
Atome Classification :
(20 SA)
---.........10........20..-......30.------.......40.....----...50..----.....--.60..--.....--.70........--------80........90.-------.......100.......110....---...120.-......130.......140.......150....-...160.......--------170.-------......-------180.......-------------190.....-..200..----------...--..210.......---.---220....--.---..230...----..-.-----------------.240....--...250...----------....260..---.-----....270--....----..--.280..------..------------...290----.......---.-----300------.......--------.310.......320......------..330.--------------......340-----------...---....350-.------------......--360--------------------------...---.-------..----------------.370-----------..-------.....----------380...------....390.......400.......410-----------------....--....-------------------.420.....-..430....------...440..-------------------.....450.......460..--.....470.....----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---
M
L
V
A
I
H
G
L
I
H
R
LGLYGEHLE
G
A
L-VNDSE
A
L
YA------HP
A
T
Y
Y
R
R
E
DLLPA----FES
N
E
A
L
----
R
E
R
F
F--GGVKK--
P
I
F
TS--ANAH
N
H
L
V
G
L
A
--------
E
V
L
A
M
Y
L
L
VWSPA-------
P
W
R
L
V
R
LEPPPGL
D
A
R
H
A
Q
R
F
AGE---
R
R
H
I
E
A
F
-
R
D
G
L
P
R
V
A
R
A
L
A
H
I
S
S
L
M
I
FDDHDITDDWN
L
S
A
-
R
W
E
L
T
AYGH
P
F
S
R
--------
R
I
I
G
-------
N
A
L
L
A
Y
-------
L
L
C
QGWGN
D
P
-------------
Q
H
C
G
E
W
L
A
-
P
V
A
A
L
M
E----------GAA--ADG-RLPC
A
E
Q
D
---
R
---
L
L
D
A
L
LD--F---Q
H
W
H
Y
RLP----GS-
P
-----------------
T
L
I
V
L
DTR--
T
R
R
W
R
SERN----------LGRPSGLM
D
---
W
-----
E
A
L
S
E
F
Q
--
Q
D
L
L----GE--K
A
A
I
I
V------SP------------A
P
M
F
G
-----
V
K
L
I
E
G
V
---
Q
-----
K
L
-------
F
S
WIGQ
P
--------
L
L
V
DA
E
N
W
M
A
HR-
G
A
A
S
V
M
M
------
N
I
F
RHS--------------RTPG
N
Y
L
I
L
-----------SGD---
V
H
Y
S
F
V
Y
-
D
------------
I
R
I
R
H
R--ERG--------------------------
P
R
L
---
W
-------
Q
I
----------------TSSG-----------IK-------
N
E
F
P
R
----------
R
L
L
D
W
F
------
D
R
L
N
R
W
LYAPW
S
P
L
N
W
L
T
QRRS
L
E
I-------------------RPRV--PQ
H
S
-------------------
Q
A
G
E
R
L
WNS-AGI
G
Q
V
F
IG------EDGR
P
R
A
V
-------------------
L
Q
VNADGSP
A
T
A
F
E
R
HRDVE--DERADQSPVAPGR----------------
36
Fugue
82.93
20%
-37
- C6 -
4GA6
3
AMPPA_THEKO
A:
[1-493]
---
M
K
A
K
I
R
I
L
D
M
F
S
G
R
Y
-----
T
V
L
-
I
N
E
E
D
A
K
E
A
------
K
----
L
H
P
D
D
L
V
K
I
----
E
A
G
K
K
--------------
A
V
Y
G
--
S
V
A
L
S
--
N
L
V
G
K
G
E
V
G
I
S
--------
R
D
V
L
-
D
L
H
N
F
S
E
G
-------
E
T
V
S
V
I
P
A
G
T
P
E
S
V
R
Y
I
K
K
K
M
H
G
E
K
L
R
K
V
E
I
E
A
I
V
R
D
I
V
D
R
K
L
R
D
I
E
I
S
S
F
V
T
A
L
E
I
N
G
L
D
M
D
E
I
A
A
L
-
T
I
A
M
A
E
T
G
D
M
L
D
I
DRKP
I
M
D
V
H
S
I
G
GVPGNK
T
N
I
L
V
V
P
-------
I
V
A
A
A
G
L
T
I
P
-------------
K
T
S
S
R
A
I
T
-
S
A
A
G
T
A
D
----------
V
V
E
V
F
A
D
V
-
S
F
S
L
D
E
I
K
---
R
---
I
V
E
K
V
G
A
--
C
---
L
V
W
----
G
----
G
A
-
L
-----------------
N
L
A
P
A
D
D
I
--
T
I
K
A
E
R
A
L
S
----------
I
D
-
P
T
G
L
M
L
---
A
-----
S
I
M
S
K
----
K
Y
A
M
----
G
S
--
Q
Y
V
L
I
D
------
I
P
T
G
KGVKVET
V
E
E
A
R
S
L
A
-----
R
D
F
I
E
L
G
---
K
-----
R
L
G
Q
Y
V
E
V
A
I
T
Y
G
G
Q
P
--------
I
G
H
T
V
G
P
A
L
E
A
R
-
E
A
L
S
A
L
M
T
GKGP
G
S
L
I
E
K
A
--------------
T
G
L
A
G
I
L
L
E
-----------
M
G
G
---
V
A
P
A
G
T
G
-
K
------------
K
M
A
K
E
I
--
L
E
S
--------------------------
G
K
A
---
W
-------
E
K
----------------
M
K
E
I
-----------
I
E
A
Q
GGDP-
N
I
K
P
E
----------
E
I
P
I
G
-------
D
K
T
Y
T
F
T
A
A
T
S
G
Y
V
T
A
I
D
N
R
A
I
T
A
I
-------------------
A
R
A
A
GA
P
E
D
K
-------------------
G
A
G
I
E
L
Y
V
K
-
V
G
-
E
K
V
---------
K
E
G
D
P
L
F
T
-------------------
I
H
A
E
H
E
A
R
L
D
Q
A
I
V
L
A
R
R
T
E
---------
P
I
R
I
E
-----------------
42
Fugue
78.70
21%
-58
- C2 -
4MTK
20
?
A:
[5-640]
---
R
L
V
Q
V
D
C
P
L
G
P
D
V
L
L
L
Q
R
M
E
G
R
E
-
E
L
G
--
R
L
F
A
------
Y
E
L
H
L
V
S
E
N
P
N
L
P
L
----
E
Q
L
L
G
K
P
----
M
S
L
S
L
E
L
P
G
G
S
R
--
R
F
F
H
G
--
I
V
A
R
C
S
Q
V
A
G
H
--------
G
Q
F
A
G
Y
Q
A
T
L
R
P
W
-------
P
W
L
L
T
R
--------
T
S
D
C
R
I
F
Q
N
Q
---
S
----------
V
P
E
I
I
K
Q
V
F
R
N
L
G
F
S
D
F
E
D
A
-
L
T
R
P
Y
R
----
E
W
E
Y
C
V
Q
Y
R
E
T
S
F
--------
D
F
I
S
-------
R
L
M
E
Q
E
-------
G
I
Y
Y
W
F
R
H
E
Q
-------------
K
R
H
I
L
V
L
S
-
D
A
Y
G
A
H
R
----------
S
P
G
--
G
Y
A
-
S
V
P
Y
Y
P
P
T
LGH
R
---
E
R
D
H
F
F
D
--
W
---
Q
M
A
R
E
V
Q
P
----
G
S
-
L
-----------------
T
L
N
D
Y
D
F
Q
RP
G
A
R
L
E
V
R
S
N
----------
I
A
R
P
H
A
A
A
D
Y
P
L
Y
-----
D
Y
P
G
E
Y
V
--
Q
S
Q
D
----
G
E
--
Q
Y
A
R
N
R
------
I
E
------------
A
I
Q
A
Q
H
E
R
--
V
R
L
R
G
V
V
---
R
GIGAG
H
L
-------
F
R
L
S
G
Y
P
RDDQN
R
E
Y
L
V
V
G
A
E
Y
R
V
V
Q
E
L
S
Q
F
E
S
E
L
------
D
C
I
D
A
S
Q
S
F
R
L
L
PQT
P
V
P
V
V
R
G
P
Q
T
A
V
V
V
G
PKGEE
I
W
T
D
Q
Y
G
R
---
V
K
V
H
F
H
W
-
D
RHDQSNENSS
C
W
I
R
V
S
Q
A
--
W
A
G
KNW
G
S
M
Q
I
P
R
I
G
Q
E
V
I
V
S
F
L
EGDPD
R
P
I
I
---
T
-------
G
R
V
Y
N
AEQTVPYELPANA
T
Q
S
G
-----------
M
K
-------
S
R
S
S
K
GGTPA
N
F
N
E
I
R
M
E
D
K
K
------
G
A
E
Q
L
Y
I
H
A
E
R
N
Q
D
N
L
V
E
N
D
A
S
L
S
V
G
H
D
R
N
K
S
I
G
H
D
E
L
A
R
I
G
N
N
R
T
R
A
--
V
K
L
N
D
T
L
L
V
G
G
A
K
S
D
S
V
T
G
T
Y
L
I
E
A
G
A
Q
I
R
L
V
-
C
G
K
S
V
V
E
F
N
------
A
D
G
T
I
N
I
S
G
S
A
F
N
L
Y
A
S
G
N
G
N
I
D
T
G
G
R
L
D
L
N
S
G
G
A
S
E
V
D
A
K
G
K
G
V
Q
G
--
T
I
D
G
Q
V
Q
A
M
F
P
P
P
----------------
39
Fugue
73.10
18%
-48
- C4 -
2Q06
-
?
A:
[22-496]
A
T
E
I
R
A
S
V
G
R
M
V
G
G
I
G
R
F
Y
I
Q
M
C
T
E
L
K
L
S
D
Q
E
G
R
L
I
------
Q
N
S
I
T
I
E
R
M
-
V
L
S
A
----
F
D
E
R
-------
R
N
R
Y
K
--
D
P
K
K
T
G
G
P
I
Y
R
R
--
R
D
G
K
-----------------
W
V
R
E
L
I
L
Y
D
K
E
-------
E
I
R
R
I
W
R
Q
A
N
N
G
E
D
A
T
--------------------
A
G
L
T
H
M
M
I
W
H
S
N
L
N
D
A
T
Y
Q
R
T
R
A
L
V
R
T
-
G
M
D
P
-
R
M
C
S
L
M
Q
G
S
T
L
P
R
--------
R
-------------------------
S
G
A
A
G
A
A
I
-------------
K
G
V
G
T
M
V
M
-
E
L
I
R
M
I
K
----------
R
G
I
--
N
D
R
-
N
F
--
W
R
G
E
---
N
---
G
R
R
T
R
I
A
--
Y
---
E
R
M
C
N
I
L
K
----
G
K
-
F
-----------------
Q
T
A
A
Q
K
A
M
--
M
D
Q
V
R
E
S
R
N
----------
P
G
-
N
A
E
I
E
D
---
L
-----
I
F
L
A
R
S
A
--
L
I
L
R
----
G
S
--
I
A
H
K
S
C
------
L
P
------------
A
C
V
Y
G
-----
L
A
V
A
S
G
Y
DFE
R
-----
E
G
-------
Y
S
L
V
G
I
D
--------
P
F
R
L
L
Q
N
---------
S
Q
V
F
------
S
L
I
R
P
N
--------------
E
N
P
A
H
K
S
Q
L
-----------
V
W
M
---
A
C
H
S
A
A
F
E
D
------------
L
R
V
S
S
F
--
I
R
G
--------------------------
T
R
V
I
P
R
G
-------
Q
L
----------------
S
T
R
G
-----------
V
Q
IASNENV
E
A
M
D
S
----------
S
T
L
E
L
R
------
S
R
--
Y
W
A
I
R
T
R
S
G
G
N
T
N
Q
Q
R
A
S
A
G
Q
-------------------
I
S
V
Q
--
P
T
F
S
-------------------
V
Q
R
N
L
P
F
E
R
-
A
T
I
M
A
A
F
K
G
NTEGRT
S
D
M
R
T
E
I
I
-------------------
R
M
M
E
S
A
R
P
E
D
V
S
F
Q
G
R
G
V
F
E
LS
D
E
K
A
T
N
P
I
V
P
S
F
D
MSNEGSYFFGDNAEEY
41
Fugue
73.02
18%
-39
- C4 -
4CWU
-
CAPSP_ADE05
N:
[52-569]
--R
N
S
I
R
Y
S
E
L
A
P
L
F
D
T
T
R
V
Y
L
V
D
N
K
-
S
T
D
V
A
S
L
N
Y
QNDHSN
F
L
T
T
V
I
Q
N
N
D
Y
S
P
G
----
E
A
S
T
Q
T
I
NLDD
R
S
H
W
G
--
G
D
L
K
T
--
I
L
H
T
N
--
M
P
N
V
N
E
F
M
F
T
N
--------
K
F
K
A
R
V
M
V
S
R
L
P
T
KDNQVEL
K
Y
E
W
V
E
F
T
L
P
E
G
N
Y
--------
S
E
---
T
M
T
I
D
L
M
-
N
N
A
I
V
E
H
Y
L
K
V
G
R
Q
N
G
V
L
---
E
S
D
I
G
V
K
F
D
T
R
N
F
R
L
G
F
D
P
V
T
G
L
V
M
P
--------
G
V
Y
T
-------
N
E
A
F
H
P
DI-----
I
L
L
P
G
C
G
V
D
F
-------------
T
H
--
S
R
L
S
-
N
L
L
G
I
R
K
----------
R
Q
P
--
F
Q
E
-
G
F
R
I
T
Y
D
D
---
L
EGG
N
I
P
A
L
L
D
--
V
---
D
A
Y
Q
A
S
L
K
----
K
P
V
I
-----------------
K
P
L
T
E
D
S
K
--
K
R
S
Y
N
L
I
S
N
----------
D
S
T
F
T
Q
Y
R
S
---
W
-----
Y
L
A
Y
N
Y
-----------
G
D
--
P
Q
T
G
I
R
------
S
W
------------
T
L
L
C
T
-----
P
D
V
T
C
G
S
---
E
-----
Q
V
-------
Y
-
W
S
L
P
D
--------
M
M
Q
D
P
V
T
---------------------
F
R
S
T
--------------
R
Q
I
S
N
F
P
V
V
-----------
G
A
E
LLP
V
H
S
K
S
F
Y
-
N
------------
D
Q
A
V
Y
S
--
Q
L
I
--------------------------
R
Q
F
---
T
-------
S
L
----------------
T
H
-------------
V
F
-------
N
R
F
P
E
-------------------------
N
Q
I
L
A
R
P
P
A
P
----
T
I
T
T
V
S
E
N
-------------------
V
P
A
L
--
T
D
H
G
-------------------
T
L
--
P
L
R
N
S
I
G
G
V
Q
R
V
T
I
T
------
D
A
R
R
R
T
C
P
-------------------
Y
V
Y
K
A
L
G
I
V
------------------
S
P
R
V
L
S
S
R
----------------
40
Fugue
70.83
18%
-32
- C7 -
1Q9J
-
PAPA5_MYCTU
A:
[1-418]
-----
M
F
P
G
S
V
I
R
K
L
-------------
S
H
S
E
E
V
F
A
------
Q
Y
E
V
F
T
S
M
T
I
Q
L
R
G
----
V
I
D
V
D
A
L
----
S
D
A
F
D
--
A
L
L
E
T
--
H
-------------------------
P
V
L
A
S
H
L
E
Q
S
S
D
G
-------
G
W
N
L
V
A
----
D
D
L
L
H
S
G
I
C
V
I
D
A
E
---
L
R
----------------
L
D
Q
S
V
S
L
L
H
L
Q
L
I
L
R
E
G
G
A
E
L
T
L
-
Y
L
H
H
C
M
A
D
G
H
H
G
A
--------
V
L
V
D
-------
E
L
F
S
R
Y
-------
T
D
A
V
T
T
G
D
P
G
-------------
P
I
T
P
Q
----
P
T
P
L
S
M
E
----------
A
V
L
--
A
Q
R
-
G
I
R
K
A
E
R
-----------------
F
---
M
S
V
M
Y
A
Y
P
----
G
L
-
P
-----------------
Q
A
V
---
P
V
--
T
R
L
W
L
S
K
Q
Q
----------
T
S
D
L
M
A
F
G
R
---
E
-----
H
R
L
S
--
L
--
N
A
V
V
--------
A
A
A
I
L
L
------
T
E
------------
W
Q
L
R
N
TPH
V
P
I
P
Y
V
Y
P
V
---
D
-----
L
R
-------
F
V
L
A
P
P
V
--------
A
P
T
E
A
T
N
L
---
L
-
G
A
A
S
Y
L
A
------
E
I
G
P
N
T
------------------
D
I
V
D
L
-----------
A
S
D
---
I
V
A
T
L
R
A
-
D
------------
L
A
N
G
V
I
--
Q
Q
S
--------------------------
G
L
H
---
F
-------
G
T
----------------
A
F
E
G
-----------
T
P
-------
P
G
L
P
P
----------
L
V
F
C
T
D
------
A
T
S
F
P
T
M
R
T
P
-
P
G
L
E
I
E
D
I
K
G
Q
F
Y
C
-------------------
S
I
S
V
--
P
L
D
L
-------------------
Y
S
C
A
V
Y
A
------
G
Q
L
I
I
E
------
H
H
G
H
I
A
E
----------------------------
P
G
K
S
L
E
A
I
R
S
L
L
--
C
T
V
P
S
E
Y
G
---------------------
44
Fugue
66.16
16%
-45
- C3 -
1VZ6
2
GNAT2_STRCL
A:
[8-390]
---
T
P
R
G
F
V
V
H
T
A
P
V
G
L
A
D
D
G
R
D
D
F
T
-
V
L
A
S
T
A
P
A
T
------
V
S
A
V
F
T
R
S
R
F
A
G
P
S
----
V
V
L
C
R
E
A
----
V
A
D
----
G
Q
A
R
G
--
V
V
V
L
A
RN
A
N
V
A
T
G
L
E
G
E
E
--------
N
A
R
E
V
R
E
A
V
A
R
A
L
--------------
G
L
P
E
G
E
M
L
I
A
S
T
G
V
I
G
R
---
Q
Y
P
M
E
S
I
-
R
E
H
L
K
T
L
E
W
P
A
G
-------------
E
G
G
F
D
R
A
A
-
R
A
I
M
T
T
D
T
R
P
K
E
V
--------
R
V
S
V
-------
G
G
A
T
L
V
-------
G
I
A
K
G
--------------------
V
G
M
L
E
P
-
D
M
A
T
L
L
T
----------
F
F
A
--
T
D
A
-
R
L
D
P
A
E
Q
D
---
R
---
L
F
R
R
V
M
D
R
T
F
---
N
A
V
S
I
D
T
D
----
T
S
-
T
S
D
---------------
T
A
V
L
F
A
N
G
--
L
A
----------------------
G
E
V
D
---
A
-----
G
E
F
E
E
A
L
--
H
T
A
A
----
L
A
--
L
V
K
D
I
A
------
S
D
------------
G
-------------
E
G
A
---
A
-----
K
L
-------
I
E
V
Q
V
T
------------
G
A
R
D
D
A
Q
A
K
-
R
V
G
K
T
V
V
------
N
----------------------------------------------------------------------------------------------------------------------------------------
S
P
L
-----------
V
K
-------
T
A
V
H
G
----------
C
D
P
N
W
-------
G
R
V
A
M
A
I
G
K
C
S
D
D
T
D
I
D
Q
E
R
V
T
I
R
F
-------------------
G
E
V
E
--
V
Y
P
P
-------------------
D
D
A
L
R
A
A
V
A
-
E
H
L
------------
R
G
D
E
V
V
I
G
-------------------
I
D
L
A
I
A
D
G
A
F
T
V
Y
G
C
D
L
T
E
G
--
Y
V
R
L
N
S
E
----------------------
37
Fugue
65.50
15%
-40
- C6 -
2YEQ
23
PPBD_BACSU
A:
[1-522]
----
A
P
N
F
S
S
Y
P
F
T
L
G
V
A
S
G
D
P
L
-----
S
D
S
V
V
L
W
T
------
R
L
A
P
D
P
L
N
G
G
G
M
P
K
Q
A
V
P
V
K
W
E
V
A
K
----
D
E
H
F
R
--
K
I
V
R
K
--
G
T
E
M
A
--
K
P
S
L
A
H
S
V
H
V
E
ADGLEPN
K
V
Y
Y
Y
R
F
K
T
G
H
E
L
S
-------
P
V
G
K
T
K
T
L
P
A
P
G
-
A
N
V
P
Q
M
T
F
A
F
A
---
S
--
C
Q
Q
Y
-
E
H
G
Y
Y
T
A
Y
K
H
M
A
K
E
K
L
D
L
V
F
H
L
G
D
Y
I
Y
E
Y
G
P
N
E
-
Y
V
S
K
T
G
N
V
R
T
H
N
S
--------
A
E
I
I
-------
T
L
Q
D
Y
R
-------
N
R
H
A
Q
Y
R
S
D
A
-------------
N
L
K
A
A
H
A
A
F
P
W
V
V
T
W
D
DHEVENNYAN
K
I
P
--
E
K
G
-
Q
S
V
E
A
F
V
L
---
R
---
R
A
A
A
Y
Q
A
Y
-
Y
---
E
H
M
P
L
R
I
S
----
S
L
-
P
NGPDMQL
Y
R
H
F
T
YGNL
A
S
F
N
V
L
D
T
R
--
Q
Y
R
D
D
Q
A
N
N
----------
D
G
N
K
P
P
S
D
E
---
S
RNPNR
T
L
L
G
K
E
Q
--
E
Q
W
L
----
F
N
--
N
L
G
S
S
T
------
A
H
------------
W
N
V
L
A
-----
Q
Q
I
F
F
A
K
---
W
-----
N
F
-------
G
T
S
A
S
P
I
--------
Y
S
M
D
S
--
W
D
G
Y
P
-
A
Q
R
E
R
V
I
------
N
F
I
K
S
---------------
K
N
L
N
N
V
V
V
L
-----------
T
G
D
---
V
H
A
S
W
A
S
-
N
------------
L
H
V
D
F
E
--
K
T
S
--------------------------
S
K
I
---
F
G
A
E
F
V
G
T
S
I
----------------
T
S
G
G
NGADKRAD
T
D
Q
I
L
-------
K
E
N
P
------------
H
I
Q
F
F
------
N
D
Y
R
G
Y
V
R
C
T
V
T
P
H
Q
W
K
A
D
Y
R
V
M
P
F
-------------------
V
T
E
P
--
G
A
A
I
-------------------
S
T
R
A
S
F
V
Y
Q
-
K
D
Q
T
G
L
R
K
V
------
S
S
T
T
I
Q
G
G
-------------------
V
K
Q
S
D
E
V
E
E
D
R
F
F
S
H
N
K
A
H
E
--
K
Q
M
I
K
K
R
----------------------
26
HHSearch
56.33
14%
-77
- C5 -
2YEQ
12
PPBD_BACSU
A:
[192-416]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
N
L
K
A
A
H
A
A
F
P
W
V
V
T
W
D
D
H
E
V
E
N
N
Y
A
N
K
I
-
P
E
K
G
--
Q
S
V
E
A
F
V
--------
L
R
R
A
-------
A
A
Y
Q
A
Y
-------
Y
E
H
-----
M
P
-------------
L
R
I
S
S
L
---------------------
P
N
---------
G
P
-
D
--------------
M
--
Q
---
L
Y
R
H
F
T
Y
G
----
N
L
-
A
-----------------
S
F
N
V
L
D
T
R
--
Q
Y
R
D
D
Q
A
N
N
DGNKPPSDES
R
N
P
N
R
T
L
L
G
---
K
-----
E
Q
E
Q
W
L
F
--
N
N
L
G
----
S
S
TA
H
W
N
V
L
A
------
Q
Q
------------
I
F
F
A
K
-----
W
N
F
G
T
------------------------
S
A
S
--------
P
I
Y
S
M
D
S
W
D
G
Y
P
-
A
Q
R
E
R
V
I
------
N
F
I
K
S
K
---------------
N
L
N
N
V
V
V
L
-----------
T
G
D
---
V
H
A
S
W
A
S
-
N
------------
L
H
V
D
F
E
KT
S
S
K
--------------------------
I
F
G
---
A
-------
E
F
----------------
V
G
T
S
-----------
I
T
-------
S
G
G
N
G
----------
A
D
K
R
A
D
------
T
D
Q
I
L
K
E
N
P
H
I
Q
F
F
N
D
Y
R
G
Y
V
R
C
T
V
-------------------
T
P
H
Q
--
W
K
A
D
-------------------
Y
R
V
M
P
F
V
T
E
-
P
G
A
A
I
S
T
R
A
------
S
F
V
Y
Q
K
D
Q
-------------------
T
G
L
R
K
V
S
S
T
T
I
Q
G
G
V
K
Q
S
D
E
--
V
E
E
D
R
F
F
S
H
N
K
A
H
----------------
14
PsiBlast_PDB
53.63
29%
-5
- C8 -
1TEM
1
BLAT_ECOLX
A:
[180-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
----------
Q
L
I
D
W
M
E
A
----
D
K
V
A
G
P
L
L
R
S
A
L
P
A
G
W
F
------------------------------
I
--
A
D
K
S
-------------------
G
A
G
E
R
--
G
S
-
R
G
I
-
I
A
A
L
G
------
P
D
G
K
P
S
R
I
-------------------
V
V
I
Y
T
T
G
S
Q
A
T
M
D
E
R
N
R
Q
I
A
--
E
I
G
A
S
L
I
K
H
W
-------------------
3
PsiBlast_PDB
52.85
29%
12
- C8 -
1ZG4
-
BLAT_ECOLX
A:
[205-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
----------
Q
L
I
D
W
M
E
A
----
D
K
V
A
G
P
L
L
R
S
A
L
P
A
G
W
F
------------------------------
I
--
A
D
K
S
-------------------
G
A
G
E
R
--
G
S
-
R
G
I
I
A
A
-
L
G
------
P
D
G
K
P
S
R
I
-------------------
V
V
I
Y
T
T
G
S
Q
A
T
M
D
E
R
N
R
Q
I
A
--
E
I
G
A
S
L
I
K
H
W
-------------------
19
PsiBlast_PDB
52.70
29%
-10
* C8 *
1YT4
-
BLAT_ECOLX
A:
[205-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
----------
Q
L
I
D
W
M
E
A
----
D
K
V
A
G
P
L
L
R
S
A
L
P
A
G
W
F
------------------------------
I
--
A
D
K
S
-------------------
G
A
G
E
R
--
G
S
-
R
G
I
-
I
A
A
L
G
------
P
D
G
K
P
S
R
I
-------------------
V
V
I
Y
T
T
G
S
Q
A
T
M
D
E
R
N
R
Q
I
A
--
E
I
G
A
S
L
I
K
H
W
-------------------
17
PsiBlast_PDB
52.33
29%
-10
- C8 -
4OQG
1
?
A:
[180-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
----------
Q
L
I
D
W
M
E
A
----
D
K
V
A
G
P
L
L
R
S
A
L
P
A
G
W
F
------------------------------
I
--
A
D
K
S
-------------------
G
A
G
E
R
--
G
S
-
R
G
I
-
I
A
A
L
G
------
P
D
G
K
P
S
R
I
-------------------
V
V
I
Y
T
T
G
S
Q
A
T
M
D
E
R
N
R
Q
I
A
--
E
I
G
A
S
L
I
K
H
W
-------------------
38
Fugue
51.80
9%
-42
* C7 *
2I7X
-
CFT2_YEAST
A:
[1-717]
-----
M
T
Y
K
Y
N
C
C
D
D
G
S
G
T
T
V
G
S
V
V
R
-
F
D
N
V
T
L
L
I
D
------
P
G
--------
W
N
P
S
----
K
V
S
Y
E
Q
C
----
I
K
Y
W
E
--
K
V
I
P
E
I-
D
V
I
I
L
--
S
Q
P
T
I
E
C
L
G
A
H
--------
S
L
L
Y
Y
N
F
T
S
H
F
I
S
-------
R
I
Q
V
Y
A
T
L
P
V
I
N
L
G
R
V
S
T
I
D
S
Y
A
S
---
A
G
V
I
G
P
Y
-
D
T
N
K
L
D
L
E
D
I
E
I
S
F
D
H
I
V
P
L
K
Y
S
Q
L
V
D
L
R
S
R
Y
D
-
G
L
T
L
L
A
Y
N
---
A
G
--------
V
C
P
G
-------
G
S
I
W
C
I
S
T
Y
S
E
K
L
V
Y
A
K
R
W
N
H
T
R
DNILNAASILDAT
G
K
P
L
S
T
L
M
-
R
P
S
A
I
I
T
----------
T
L
D
--
R
F
G
S
S
Q
P
F
K
K
R
S
---
K
---
I
F
K
D
T
L
K
--
K
G
L
S
S
D
G
S
V
I
I
P
V
DMS
G
K
-
F
-----------------
L
D
L
F
T
Q
V
H
--
E
L
L
F
E
S
Q
V
P
----------
V
L
I
L
S
Y
-
A
R
---
G
-----
R
T
L
T
Y
A
K
S
M
L
E
W
L
----
S
P
--
S
L
L
K
T
W
E
N
R
NNT
S
P
------------
F
E
I
G
S
-----
R
I
K
I
I
A
P
---
N
-----
E
L
-------
S
K
Y
P
G
S
K
--------
I
C
F
V
S
------
E
-
V
G
A
L
I
N
E
------
V
I
I
K
V
G
--------------
N
S
E
K
T
T
L
I
L
-----------
T
K
P
---
S
F
E
C
A
S
S
-
L
------------
D
K
I
L
E
I
--
V
E
Q
--------------------------
D
E
D
---
G
-------
K
S
----------------
F
L
C
D
-----------
N
Y
-------
I
S
I
D
T
----------
I
K
E
E
P
L
SKEETN
F
D
N
L
D
Y
L
K
I
D
K
T
L
S
K
R
T
I
S
T
V
N
V
Q
L
-------------------
K
C
S
V
--
V
I
L
N
-------------------
L
Q
S
----
L
V
-
D
Q
R
S
A
S
I
I
W
------
P
S
L
K
S
R
K
I
-------------------
V
L
S
A
P
K
Q
I
Q
N
E
E
I
T
A
K
L
I
K
K
--
N
I
E
V
V
N
M
P
L
N
K
I
V
E
F
S-------------
13
PsiBlast_PDB
51.73
29%
-8
- C8 -
1BTL
1
BLAT_ECOLX
A:
[180-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
----------
Q
L
I
D
W
M
E
A
----
D
K
V
A
G
P
L
L
R
S
A
L
P
A
G
W
F
------------------------------
I
--
A
D
K
S
-------------------
G
A
G
E
R
--
G
S
-
R
G
I
-
I
A
A
L
G
------
P
D
G
K
P
S
R
I
-------------------
V
V
I
Y
T
T
G
S
Q
A
T
M
D
E
R
N
R
Q
I
A
--
E
I
G
A
S
L
I
K
H
W
-------------------
32
HHSearch
51.60
16%
-94
- C5 -
3TGH
3
?
A:
[150-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
-
A
-----------------
A
F
I
F
I
D
T
W
--
V
L
S
S
N
F
----------------
P
Y
K
K
I
H
---
E
-----
K
A
W
N
D
L
K
--
S
Q
L
S
V
A
K
K
I
A
--
D
F
I
I
V
V
------
G
D
------------
Q
P
I
Y
S
-----
S
G
Y
S
--------------------------------------------
R
G
S
S
-
Y
L
A
Y
Y
L
L
------
P
L
L
K
D
-----------------
A
E
V
D
L
Y
I
-----------
S
G
H
---
D
N
N
M
E
V
I
-
E
------------
D
------------------------------------
N
D
M
---
A
-------
H
I
----------------
T
C
G
S
-----------
G
S
-------
M
S
Q
G
K
----------
S
G
M
K
N
S
------
K
S
L
F
F
S
S
D
I
G
F
C
V
H
E
L
S
N
N
G
I
V
T
K
F
-------------------
V
S
S
K
--
K
G
E
V
-------------------
I
Y
T
H
K
L
N
I
K
-
K
K
K
T
L
D
K
V
N
------
A
L
Q
H
F
A
A
L
-------------------
P
N
V
E
L
T
D
V
P
S
S
G
P
M
G
------------------------------------
7
PsiBlast_PDB
51.45
29%
-5
- C8 -
4RVA
1
BLAT_ECOLX
A:
[180-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
----------
Q
L
I
D
W
M
E
A
----
D
K
V
A
G
P
L
L
R
S
A
L
P
A
G
W
F
------------------------------
I
--
A
D
K
S
-------------------
G
A
G
E
R
--
G
S
-
R
G
I
-
I
A
A
L
G
------
P
D
G
K
P
S
R
I
-------------------
V
V
I
Y
T
T
G
S
Q
A
T
M
D
E
R
N
R
Q
I
A
--
E
I
G
A
S
L
I
K
H
W
-------------------
9
PsiBlast_PDB
51.33
29%
-4
- C8 -
3JYI
2
BLAT_ECOLX
A:
[180-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
----------
Q
L
I
D
W
M
E
A
----
D
K
V
A
G
P
L
L
R
S
A
L
P
A
G
W
F
------------------------------
I
--
A
D
K
S
-------------------
G
A
G
E
R
--
G
S
-
R
G
I
-
I
A
A
L
G
------
P
D
G
K
P
S
R
I
-------------------
V
V
I
Y
T
T
G
S
Q
A
T
M
D
E
R
N
R
Q
I
A
--
E
I
G
A
S
L
I
K
H
W
-------------------
1
PsiBlast_PDB
51.32
29%
-4
- C8 -
1LHY
-
BLAT_ECOLX
A:
[180-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
----------
Q
L
I
D
W
M
E
A
----
D
K
V
A
G
P
L
L
R
S
A
L
P
A
G
W
F
------------------------------
I
--
A
D
K
S
-------------------
G
A
G
E
R
--
G
S
-
S
G
I
-
I
A
A
L
G
------
P
D
G
K
P
S
R
I
-------------------
V
V
I
Y
T
T
G
S
Q
A
T
M
D
E
R
N
R
Q
I
A
--
E
I
G
A
S
L
I
K
H
W
-------------------
2
PsiBlast_PDB
51.28
29%
-10
- C8 -
4RX3
1
BLAT_ECOLX
A:
[180-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
----------
Q
L
I
D
W
M
E
A
----
D
K
V
A
G
P
L
L
R
S
A
L
P
A
G
W
F
------------------------------
I
--
A
D
K
S
-------------------
G
A
G
E
R
--
G
S
-
R
G
I
-
I
A
A
L
G
------
P
D
G
K
P
S
R
I
-------------------
V
V
I
Y
T
T
G
S
Q
A
T
M
D
E
R
N
R
Q
I
A
--
E
I
G
A
S
L
I
K
H
W
-------------------
12
PsiBlast_PDB
51.00
29%
-12
- C8 -
1AXB
1
BLAT_ECOLX
A:
[180-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
----------
Q
L
I
D
W
M
E
A
----
D
K
V
A
G
P
L
L
R
S
A
L
P
A
G
W
F
------------------------------
I
--
A
D
K
S
-------------------
G
A
G
E
R
--
G
S
-
R
G
I
-
I
A
A
L
G
------
P
D
G
K
P
S
R
I
-------------------
V
V
I
Y
T
T
G
S
Q
A
T
M
D
E
R
N
R
Q
I
A
--
E
I
G
A
S
L
I
K
H
W
-------------------